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https://www.readbyqxmd.com/read/29348018/myocardial-inflammation-predicts-remodeling-and-neuroinflammation-after-myocardial-infarction
#1
James T Thackeray, Henri C Hupe, Yong Wang, Jens P Bankstahl, Georg Berding, Tobias L Ross, Johann Bauersachs, Kai C Wollert, Frank M Bengel
BACKGROUND: The local inflammatory tissue response after acute myocardial infarction (MI) determines subsequent healing. Systemic interaction may induce neuroinflammation as a precursor to neurodegeneration. OBJECTIVES: This study sought to assess the influence of MI on cardiac and brain inflammation using noninvasive positron emission tomography (PET) of the heart-brain axis. METHODS: After coronary artery ligation or sham surgery, mice (n = 49) underwent serial whole-body PET imaging of the mitochondrial translocator protein (TSPO) as a marker of activated macrophages and microglia...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29337840/targeted-temperature-management-at-33%C3%A2-c-or-36%C3%A2-c-produces-equivalent-neuroprotective-effects-in-the-middle-cerebral-artery-occlusion-rat-model-of-ischemic-stroke
#2
Jung Ho Lee, Jisoo Lim, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim, Je Sung You
Targeted temperature management (TTM, 32°C to 36°C) is one of the most successful achievements in modern resuscitation medicine. It has become standard treatment for survivors of sudden cardiac arrest to minimize secondary brain damage. TTM at 36°C is just as effective as TTM at 33°C and is actually preferred because it reduces adverse TTM-associated effects. TTM also likely has direct neuroprotective effects in ischemic brains in danger of stroke. It remains unclear, however, whether higher temperature TTM is equally effective in protecting the brain from the effects of stroke...
January 15, 2018: Shock
https://www.readbyqxmd.com/read/29299616/increased-variability-of-watershed-areas-in-patients-with-high-grade-carotid-stenosis
#3
Stephan Kaczmarz, Vanessa Griese, Christine Preibisch, Michael Kallmayer, Michael Helle, Isabel Wustrow, Esben Thade Petersen, Hans-Henning Eckstein, Claus Zimmer, Christian Sorg, Jens Göttler
PURPOSE: Watershed areas (WSAs) of the brain are most susceptible to acute hypoperfusion due to their peripheral location between vascular territories. Additionally, chronic WSA-related vascular processes underlie cognitive decline especially in patients with cerebral hemodynamic compromise. Despite of high relevance for both clinical diagnostics and research, individual in vivo WSA definition is fairly limited to date. Thus, this study proposes a standardized segmentation approach to delineate individual WSAs by use of time-to-peak (TTP) maps and investigates spatial variability of individual WSAs...
January 3, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29276498/role-of-hyperintense-acute-reperfusion-marker-for-classifying-the-stroke-etiology
#4
Hee Young Choi, Kyung Mi Lee, Hyug-Gi Kim, Eui Jong Kim, Woo Suk Choi, Bum Joon Kim, Sung Hyuk Heo, Dae-Il Chang
Purpose: The hyperintense acute reperfusion marker (HARM) is a delayed enhancement of the subarachnoid or subpial space observed on post-contrast fluid-attenuated inversion recovery (FLAIR) images and is associated with permeability changes to the blood-brain barrier in acute stroke. We investigated the relationship between HARM and stroke etiology based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification. In addition, we evaluated the relationship between HARM and stroke locations with respect to vascular territories and anatomic compartments...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29237797/endothelial-progenitor-cells-enhance-blood-brain-barrier-permeability-in-subacute-stroke
#5
João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, André Amorim, Susana Sousa, Ana Catarina Gomes, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
OBJECTIVE: To study the association among endothelial progenitor cells (EPCs), subacute blood-brain barrier (BBB) permeability, and clinical outcome after ischemic stroke, determining the micro RNAs of EPCs responsible for good clinical outcome. METHODS: We included consecutive patients with nonlacunar acute ischemic strokes in the territory of a middle cerebral artery and ages between 18 and 80 years. Clinical outcome was defined as modified Rankin Scale score at 3 months...
December 13, 2017: Neurology
https://www.readbyqxmd.com/read/29228907/secondary-pallidonigral-degeneration-mimicking-recurrent-acute-stroke-in-clinical-presentation-and-magnetic-resonance-imaging-a-case-report
#6
Ruei-Je Tsai, Li-Chun Hsieh, Sho-Jen Cheng, Cheng-Yu Chen
BACKGROUND: Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration following a previous putaminal infarct, which was diagnosed through diffusion-weighted (DWI) and T2-weighted imaging (T2WI). CASE PRESENTATION: A 64-year-old man complained of an acute relapse of right-lower-limb weakness following a cerebral infarction 2 months before presentation...
December 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29217363/positional-brain-single-photon-emission-computed-tomography-findings-in-a-case-of-limb-shaking-syndrome
#7
Caroline Bund, Céline Heimburger, Valérie Wolff, Izzie Jacques Namer
An 84-year-old man, who presented lower limbs limb-shaking syndrome at orthostatism lasting a few seconds, was referred in our stroke unit. Magnetic resonance imaging showed an acute infarction in the right thalamus and the insular cortex, left extracranial carotid stenosis at 80%, and low flow in the right middle cerebral artery but did not explain limb-shaking syndrome symptomatology. We performed comparative positional brain perfusion single-photon emission computed tomography (SPECT), in the upright and in the supine position, to explore and localize hypoperfusion-endangered brain structures that may be involved in the presenting symptoms...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29193196/extracranial-and-intracranial-ultrasonographic-findings-in-posterior-circulation-infarction
#8
Hsin-Yi Chi, Chung-Fu Hsu, An-Chih Chen, Chun-Hung Su, Han-Hwa Hu, Wen-Mei Fu
OBJECTIVES: Patients with posterior circulation infarction are at higher risk of early recurrent stroke, especially those with vertebrobasilar stenosis or hypoplasia. The clinical presentations of this condition vary over a broad range, making diagnosis and treatment a challenge. Hemodynamic changes and stenosis detected by ultrasonography (US) are sensitive and important indicators for further evaluation. In this study, we correlated extracranial and intracranial US characteristics with brain magnetic resonance imaging (MRI) in patients with posterior circulation infarction...
November 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29191741/thrombolytic-therapy-of-acute-ischemic-stroke-during-early-pregnancy
#9
Anne Landais, Hugo Chaumont, Rachel Dellis
Thrombolytic treatment (recombinant tissue plasminogen activator [rt-PA]) has established efficacy in acute ischemic stroke, but pregnancy has been an exclusion criterion for all clinical trials that validated alteplase in acute stroke, so our knowledge about its use in this condition is limited. Herein we report the successful use of intravenous rt-PA thrombolysis, uncomplicated by neither hemorrhage development nor other complication in a woman who was 13 weeks pregnant with acute ischemic stroke. The brain magnetic resonance imaging diffusion-weighted sequences showed increased signal in the territory of the left middle cerebral artery...
November 28, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29171362/complications-of-endovascular-treatment-for-acute-ischemic-stroke-prevention-and-management
#10
Joyce S Balami, Philip M White, Peter J McMeekin, Gary A Ford, Alastair M Buchan
Endovascular mechanical thrombectomy (MT) for the treatment of acute stroke due to large vessel occlusion has evolved significantly with the publication of multiple positive thrombectomy trials. MT is now a recommended treatment for acute ischemic stroke. Mechanical thrombectomy is associated with a number of intra-procedural or post-operative complications, which need to be minimized and effectively managed to maximize the benefits of thrombectomy. Procedural complications include: access-site problems (vessel/nerve injury, access-site hematoma and groin infection); device-related complications (vasospasm, arterial perforation and dissection, device detachment/misplacement); symptomatic intracerebral hemorrhage; subarachnoid hemorrhage; embolization to new or target vessel territory...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29166955/brain-arterial-diameters-and-cognitive-performance-the-northern-manhattan-study
#11
Jose Gutierrez, Erin Kulick, Yeseon Park Moon, Chuanhui Dong, Ken Cheung, Bagci Ahmet, Yaakov Stern, Noam Alperin, Tatjana Rundek, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind
OBJECTIVES: To test the hypothesis that brain arterial diameters are associated with cognitive performance, particularly in arteries supplying domain-specific territories. METHODS: Stroke-free participants in the Northern Manhattan Study were invited to have a brain MRI from 2003-2008. The luminal diameters of 13 intracranial arterial segments were obtained using time-of-flight magnetic resonance angiogram (MRA), and then averaged and normalized into a global score and region-specific arterial diameters...
November 23, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29166459/could-infarct-location-predict-the-long-term-functional-outcome-in-childhood-arterial-ischemic-stroke
#12
Mauricio López-Espejo, Marta Hernández-Chávez
OBJECTIVE: To explore the influence of infarct location on long-term functional outcome following a first-ever arterial ischemic stroke (AIS) in non-neonate children. METHOD: The MRIs of 39 children with AIS (median age 5.38 years; 36% girls; mean follow-up time 5.87 years) were prospectively evaluated. Infarct location was classified as the absence or presence of subcortical involvement. Functional outcome was measured using the modified Rankin scale (mRS) for children after the follow-up assessment...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29165559/impact-of-pre-admission-oral-anticoagulation-on-ischaemic-stroke-volume-lesion-pattern-and-frequency-of-intracranial-arterial-occlusion-in-patients-with-atrial-fibrillation
#13
Joanna Dietzel, Sophie K Piper, Rudi Ruschmann, Christian Wollboldt, Tatiana Usnich, Simon Hellwig, Ivana Galinovic, Heinrich J Audebert, Matthias Endres, Kersten Villringer, Jochen B Fiebach, Karl Georg Haeusler
Aims: Therapeutic oral anticoagulation on hospital admission reduces morbidity and mortality after acute ischaemic stroke in patients with atrial fibrillation (AF). The underlying mechanism is not fully understood. In order to assess the impact of INR-level on admission on stroke volume, lesion pattern and the frequency of intracranial arterial occlusion, we analysed serial MRI measurements in AF patients suffering acute ischaemic stroke. Methods: and results This subgroup analysis of the prospective '1000Plus' study included patients with acute ischaemic stroke and known AF or a first episode of AF in hospital...
November 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29154893/an-interleaved-sequence-for-simultaneous-magnetic-resonance-angiography-mra-susceptibility-weighted-imaging-swi-and-quantitative-susceptibility-mapping-qsm
#14
Yongsheng Chen, Saifeng Liu, Sagar Buch, Jiani Hu, Yan Kang, E Mark Haacke
PURPOSE: To image the entire vasculature of the brain with complete suppression of signal from background tissue using a single 3D excitation interleaved rephased/dephased multi-echo gradient echo sequence. This ensures no loss of signal from fast flow and provides co-registered susceptibility weighted images (SWI) and quantitative susceptibility maps (QSM) from the same scan. MATERIALS AND METHODS: The suppression of background tissue was accomplished by subtracting the flow-dephased images from the flow-rephased images with the same echo time of 12...
November 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29131823/prevalence-of-extracranial-carotid-artery-aneurysms-in-patients-with-an-intracranial-aneurysm
#15
V E C Pourier, C J H C M van Laarhoven, M D I Vergouwen, G J E Rinkel, Gert J de Borst
BACKGROUND AND PURPOSE: Aneurysms in various arterial beds have common risk- and genetic factors. Data on the correlation of extracranial carotid artery aneurysms (ECAA) with aneurysms in other vascular territories are lacking. We aimed to investigate the prevalence of ECAA in patients with an intracranial aneurysm (IA). METHODS: We used prospectively collected databases of consecutive patients registered at the University Medical Center Utrecht with an unruptured intracranial aneurysm (UIA) or aneurysmal Subarachnoid hemorrhage (SAH)...
2017: PloS One
https://www.readbyqxmd.com/read/29125025/choroid-plexus-avm-with-anomalous-origin-of-the-capsulothalamic-artery-a-case-report
#16
Shigeru Yamauchi, Taichiro Kawakami, Keiji Murata, Tomoya Ishiguro, Hidetoshi Ikeda, Akimasa Nishio
Background and importance Traditionally, it has been believed that the plexal segment of the anterior choroidal artery (AChoA) can be sacrificed safely. Here, we present a case of choroid plexus arteriovenous malformation (AVM) in which the capsulothalamic artery originated from distal plexal segment of the AChoA. Clinical presentation A 45-year-old man was diagnosed with arteriovenous malformation involving the left inferior horn in screening MRI. Preceding stereotactic radiosurgery, transarterial target embolization was performed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29121965/chronic-cerebral-hypoperfusion-induces-post-stroke-dementia-following-acute-ischemic-stroke-in-rats
#17
Dong Bin Back, Kyoung Ja Kwon, Dong-Hee Choi, Chan Young Shin, Jongmin Lee, Seol-Heui Han, Hahn Young Kim
BACKGROUND: Post-stroke dementia (PSD) is one of the major consequences after stroke. Chronic cerebral hypoperfusion (CCH) can induce vascular cognitive impairment and potentiate amyloid pathology. We investigated how CCH contributes to the development of PSD after stroke in the context of neuroinflammation and amyloid pathology. METHODS: We designed a unique animal model for PSD. We performed middle cerebral artery occlusion (MCAO) surgery in rats mimicking acute territorial infarct, which was followed by bilateral common carotid artery occlusion (BCCAo) surgery mimicking CCH...
November 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29079431/voluntary-running-enhances-glymphatic-influx-in-awake-behaving-young-mice
#18
Stephanie von Holstein-Rathlou, Nicolas Caesar Petersen, Maiken Nedergaard
Vascular pathology and protein accumulation contribute to cognitive decline, whereas exercise can slow vascular degeneration and improve cognitive function. Recent investigations suggest that glymphatic clearance measured in aged mice while anesthetized is enhanced following exercise. We predicted that exercise would also stimulate glymphatic activity in awake, young mice with higher baseline glymphatic function. Therefore, we assessed glymphatic function in young female C57BL/6J mice following five weeks voluntary wheel running and in sedentary mice...
January 1, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29025779/scorpion-bite-induced-ischaemic-stroke
#19
Rakesh Reddy C, Nandakishore Bompelli, Vikram Khardenavis, Anirudda Deshpande
We report a 54-year-old woman with scorpion bite. After 3 hours of admission, the patient developed sudden onset tachycardia with hypotension. Cardiac evaluation showed raised creatine kinase MB isoenzyme was elevated; ECG and two-dimensional echocardiography findings were suggestive of myocarditis. Subsequently, she developed transient ventricular tachycardia before developing abrupt onset, right hemiplegia, global aphasia and progressive worsening of sensorium 12 hours after the bite. MRI of brain revealed massive left middle cerebral artery (MCA) territory infarct...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29019892/bright-sinus-appearance-on-arterial-spin-labeling-mr-imaging-aids-to-identify-cerebral-venous-thrombosis
#20
Ji Hee Kang, Tae Jin Yun, Roh-Eul Yoo, Byung-Woo Yoon, A Leum Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cerebral venous thrombosis is a potentially lethal disease. Early diagnosis is essential to improve its prognosis. However, its early diagnosis based on conventional imaging modalities remains a challenge in clinical settings. The purpose of this study was to evaluate whether bright sinus appearance on arterial spin-labeling perfusion-weighted image (ASL-PWI) could help identify cerebral venous thrombosis.ASL-PWI of 13 patients who were confirmed as cerebral venous thrombosis based on neurologic symptoms and computed tomography (CT) or magnetic resonance (MR) venography (with/without cerebral angiography) were retrospectively analyzed for the presence or absence of the following: bright signal in dural sinus termed "bright sinus appearance"; and hypoperfusion in brain parenchyma drained by thrombosed sinus...
October 2017: Medicine (Baltimore)
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