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Self-assembling peptide

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https://www.readbyqxmd.com/read/28454062/self-assembled-dehydropeptide-nano-carriers-for-delivery-of-ornidazole-and-curcumin
#1
Smriti Rekha Deka, Santosh Yadav, Dheeresh Kumar, Sumit Garg, Manohar Mahato, Ashwani Kumar Sharma
In the recent studies, it has been demonstrated that incorporation of unnatural amino acid, α,β-dehydrophenylalanine, in small peptides results in stable self-assembled nanostructures with different sizes and shapes. Here, we have replaced the natural amino acid, phenylalanine, from our earlier reported work on self-assembled peptide, Boc-Pro-Phe-Gly-OMe, with a constrained dehydro amino acid, α,β-dehydrophenylalanine, to study its influence on self-assembled nanostructures. Dehydrotripeptide, Boc-Pro-ΔPhe-Gly-OMe, self-assembled into nanostructures in aqueous solutions and formed hydrophobic matrix with improved encapsulation efficiency of hydrophobic molecules...
April 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28453939/all-atom-molecular-dynamics-simulations-of-peptide-amphiphile-assemblies-that-spontaneously-form-twisted-and-helical-ribbon-structures
#2
Cheng-Tsung Lai, Nathaniel L Rosi, George C Schatz
Self-assembly of peptide amphiphiles (PAs) has been an active research area as the assemblies can be programmed into various shaped nanostructures. Although cylindrical micelles are common structures, gold-binding peptide conjugates PEPAu can self-assemble into chiral nanofibers with single or double helices. When gold nanoparticles bind to the helices, the resulting chiral nanoparticle assemblies have a collective plasmonic circular dichroism signal that can serve as nanoscale circular polarizers or chiroptical sensors...
April 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28449250/self-assembly-of-peptide-boroxoles-on-cis-dihydroxylated-oligoamide-templates-in-water
#3
André Wuttke, Armin Geyer
We develop templates that can be used to stabilize consistent oligomers of a bioactive peptide. In the present study, we synthesize oligomers of an antibody epitope from the amyloidogenic prion protein. Dynamic covalent chemistry is the basis for the spontaneous condensation of 2, 3, 4 or 6 peptides with qualified polyol templates presenting the required number of bioorthogonal ligation sites. To study this process in aqueous solution, the N-terminal amino acid of a 13-mer peptide is first acylated with 4-carboxy-benzoboroxole (1-hydroxy-1,3-dihydrobenzo[c][1,2] oxaborole-5-carboxylic acid) and then mixed with the template to obtain self-assembled miniamyloids of specified degree of oligomerization...
April 27, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28447683/self-assembled-hybrid-elastin-like-polypeptide-silica-nanoparticles-enable-triggered-drug-release
#4
Wei Han, Ashutosh Chilkoti, Gabriel P López
The discovery of biomimetic polypeptides that enable the biomineralization of synthetic and biosynthetic materials has resulted in the development of hybrid materials that incorporate inorganic components for potential application in drug delivery, enzyme immobilization, and surface modification. Here, we describe an approach that uses micellar assemblies of an elastin-like polypeptide (ELP) modified with silica-promoting sequences and drug conjugates that are subsequently encapsulated within a silica matrix...
April 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447085/studying-structure-and-dynamics-of-self-assembled-peptide-nanostructures-using-fluorescence-and-super-resolution-microscopy
#5
Sílvia Pujals, Kai Tao, Adrià Terradellas, Ehud Gazit, Lorenzo Albertazzi
Understanding the formation and properties of self-assembled peptide nanostructures is the basis for the design of new architectures for various applications. Here we show the potential of fluorescence and super resolution imaging to unveil the structural and dynamic features of peptide nanofibers with high spatiotemporal resolution.
April 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28446340/peptide-dendrimer-lipid-conjugates-as-dna-and-sirna-transfection-reagents-role-of-charge-distribution-across-generations
#6
Marc Heitz, Albert Kwok, Gabriela A Eggimann, Florian Hollfelder, Tamis Darbre, Jean-Louis Reymond
Transfection reagents are used to deliver DNA and siRNA into cells to achieve genetic manipulations, and may ultimately enable nonviral gene therapy. Progress in transfection reagents is limited by the fact that such reagents cannot be easily optimized due to their polymeric nature and/or difficult synthesis. We have developed a new class of well-defined and easily modifiable transfection reagents in the form of peptide dendrimers. These dendrimers self-assemble with DNA or siRNA and lipofectin to form nanoparticles which efficiently enter mammalian cells and liberate their nucleic acid cargo...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28441471/gemcitabine-integrated-nano-prodrug-carrier-system
#7
Seren Hamsici, Melis Sardan Ekiz, Goksu Cinar Ciftci, Ayse Begum Tekinay, Mustafa O Guler
Peptide nanomaterials have received a great deal of interest in drug delivery applications due to their biodegradability, biocompatibility, suitability for large scale synthesis, high drug loading capacities, targeting ability and ordered structural organization. The covalent conjugation of drugs to peptide backbone results in prolonged circulation time and improved stability of drugs. Therapeutic efficacy of gemcitabine, which is used for breast cancer treatment, is severely compromised due to its rapid plasma degradation...
April 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28440566/c%C3%A2-%C3%A2-c%C3%A2-helical-folding-in-%C3%AE-%C3%AE-hybrid-peptides-containing-1-aminocyclohexane-acetic-acid-%C3%AE-%C3%A2-%C3%A2-%C3%A2-ac%C3%A2-c
#8
Naiem Ahmad Wani, Srinivasarao Raghothama, Umesh Prasad Singh, Rajkishor Rai
The present study describes the solid state conformation of αβ hybrid peptides, Boc-Leu-β³,³-Ac₆c-OH, P1; Boc-Leu-β³,³-Ac₆c-Leu-β³,³-Ac₆c-OMe, P2 and Boc-Leu-β³,³-Ac₆c-Leu-β³,³-Ac₆c-Leu-OMe, P3. The dipeptide P1 adopts extended conformations, while tetrapeptide P2 and peptapeptide P3 favor helical conformation stabilized by C₁₁/C₉ intramolecular hydrogen bonds. In peptide P3, amino group of β³,³-Ac₆c(2) and β³,³-Ac₆c(4) residues occupies axial orientation, while in P2, it occupies axial and equatorial orientations for residues β³,³-Ac₆c(2) and β³,³-Ac₆c(4), respectively...
April 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28435909/self-assembled-particulate-psaa-as-vaccine-against-streptococcus-pneumoniae-infection
#9
Majela González-Miro, Laura Rodríguez-Noda, Mildrey Fariñas-Medina, Dagmar García-Rivera, Vicente Vérez-Bencomo, Bernd H A Rehm
Streptococcus pneumoniae is a human pathogen responsible for the majority of childhood pneumonia and media otitis cases worldwide. The diversity of its capsular polysaccharides (CPS) results in more than 91 serotypes of which at least 23 are virulent. Various CPS conjugated to immunogenic carrier proteins are currently licensed and provide protection against the infection caused by the respective serotypes but not against new and emerging virulent serotypes. In this study, we considered the conserved protein antigen PsaA, the pneumococcal surface adhesin A, in order to overcome the limitations of CPS antigens...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28435772/self-assembled-bifunctional-peptide-as-effective-drug-delivery-vector-with-powerful-antitumor-activity
#10
Rangrang Fan, Lan Mei, Xiang Gao, Yuelong Wang, Mingli Xiang, Yu Zheng, Aiping Tong, Xiaoning Zhang, Bo Han, Liangxue Zhou, Peng Mi, Chao You, Zhiyong Qian, Yuquan Wei, Gang Guo
E-cadherin/catenin complex is crucial for cancer cell migration and invasion. The histidine-alanine-valine (HAV) sequence has been shown to inhibit a variety of cadherin-based functions. In this study, by fusing HAV and the classical tumor-targeting Arg-Gly-Asp (RGD) motif and Asn-Gly-Arg (NGR) motif to the apoptosis-inducing peptide sequence-AVPIAQK, a bifunctional peptide has been constructed with enhanced tumor targeting and apoptosis effects. This peptide is further processed as a nanoscale vector to encapsulate the hydrophobic drug docetaxel (DOC)...
April 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28430192/a-monodisperse-transmembrane-%C3%AE-helical-peptide-barrel
#11
Kozhinjampara R Mahendran, Ai Niitsu, Lingbing Kong, Andrew R Thomson, Richard B Sessions, Derek N Woolfson, Hagan Bayley
The fabrication of monodisperse transmembrane barrels formed from short synthetic peptides has not been demonstrated previously. This is in part because of the complexity of the interactions between peptides and lipids within the hydrophobic environment of a membrane. Here we report the formation of a transmembrane pore through the self-assembly of 35 amino acid α-helical peptides. The design of the peptides is based on the C-terminal D4 domain of the Escherichia coli polysaccharide transporter Wza. By using single-channel current recording, we define discrete assembly intermediates and show that the pore is most probably a helix barrel that contains eight D4 peptides arranged in parallel...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28430190/tuning-underwater-adhesion-with-cation-%C3%AF-interactions
#12
Matthew A Gebbie, Wei Wei, Alex M Schrader, Thomas R Cristiani, Howard A Dobbs, Matthew Idso, Bradley F Chmelka, J Herbert Waite, Jacob N Israelachvili
Cation-π interactions drive the self-assembly and cohesion of many biological molecules, including the adhesion proteins of several marine organisms. Although the origin of cation-π bonds in isolated pairs has been extensively studied, the energetics of cation-π-driven self-assembly in molecular films remains uncharted. Here we use nanoscale force measurements in combination with solid-state NMR spectroscopy to show that the cohesive properties of simple aromatic- and lysine-rich peptides rival those of the strong reversible intermolecular cohesion exhibited by adhesion proteins of marine mussel...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28426067/bioinspired-peptosomes-with-programmed-stimuli-responses-for-sequential-drug-release-and-high-performance-anticancer-therapy
#13
Yuan Li, Wei Li, Weier Bao, Bin Liu, Dan Li, Yumeng Jiang, Wei Wei, Fazheng Ren
Combination therapy with enhanced therapeutic and antimetastatic efficacy has become promising for cancer treatment. There is an urgent need to design a co-delivery system to sequentially release the drug pair at desired locations that can increase the intra-tumoral drug concentration and reduce the side effects. Inspired by virus architecture and function, herein, we developed a peptosome (PS)-based co-delivery system, PePm/PS/Curcumin (Cur), for the sequential release of the therapeutic peptide Pe and chemodrug Cur...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28422790/particle-based-delivery-of-the-hiv-envelope-protein
#14
Benedikt Asbach, Ralf Wagner
PURPOSE OF REVIEW: A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to efficiently engage B cells, thus leading to affinity maturation that results in superior antibody responses characterized by improved breadth, potency, and durability. This review summarizes current work that is evaluating diverse types of such particulate carriers for Env delivery...
May 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28420679/tumor-microenvironment-targeting-and-responsive-peptide-based-nanoformulations-for-improved-tumor-therapy
#15
Hao Qin, Yanping Ding, Ayeesha Mujeeb, Ying Zhao, Guangjun Nie
Tumor microenvironment participates in all stages of tumor progression and has emerged as a promising therapeutic target for cancer therapy. Rapid progress in the field of molecular self-assembly using various biological molecules has resulted in the fabrication of nanoformulations, specifically targeting and regulating the microenvironment components to inhibit tumor malignancies. This inhibition process is based on the differentiating biophysicochemical cues guiding tumor and normal tissue microenvironments...
April 18, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28414234/impact-of-mutations-at-c-terminus-on-structures-and-dynamics-of-a%C3%AE-40-and-a%C3%AE-42-molecular-simulation-study
#16
Nguyen Hoang Linh, Thu Thi Minh Tran, Ly Anh Tu, Chin-Kun Hu, Mai Suan Li
Alzheimer's disease is presumably caused by formation of intracellular plaques of amyloid beta (Aβ) peptides inside neurons. The most abundant Aβ forms are Aβ40 and Aβ42 composing, respectively, of 40 and 42 residues. Recent experiments showed that triple Gly33Val-Val36Pro-Gly38Val (VPV) mutation makes Aβ42 become super-Aβ42 with elevated aggregation rates and toxicity. Upon VPV mutation oligomerization pathways of Aβ40 become similar to those of Aβ42 wild type. It was hypothesized that the super behavior of Aβ42 occurs due to enhanced content of the β-turn and β-hairpin, centered at residues 36-37 , while the similarity of oligomerization pathways of Aβ40-VPV and Aβ42-WT comes from increased β-turn population...
April 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28411807/a-sensitive-and-disposable-indium-tin-oxide-based-electrochemical-immunosensor-for-label-free-detection-of-mage-1
#17
Burçak Demirbakan, Mustafa Kemal Sezgintürk
MAGE-1 (MAGE, for melanoma antigen), was identified by virtue of its processing and cell surface expression as a tumor-specific peptide bound to major histocompatibility complexes which was reactive with autolytic T cells. 3-Glycidoxypropyltrimethoxysilane (3-GOPS) is frequently employed for the preparation of dense heterometal hybrid polymers which are used, e.g., for hard coatings of organic polymers and contact lens materials in the optical industry. In this study, we have improved a new immunological biosensor with indium tin oxide (ITO)...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411182/pegylation-rate-influences-peptide-based-nanoparticles-mediated-sirna-delivery-in-vitro-and-in-vivo
#18
Gudrun Aldrian, Anaïs Vaissière, Karidia Konate, Quentin Seisel, Eric Vivès, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Héléne Démèné, Dina Aggad, Aurélie Covinhes, Stéphanie Barrère-Lemaire, Sébastien Deshayes, Prisca Boisguerin
Small interfering RNAs (siRNAs) present a strong therapeutic potential because of their ability to inhibit the expression of any desired protein. Recently, we developed the retro-inverso amphipathic RICK peptide as novel non-covalent siRNA carrier. This peptide is able to form nanoparticles (NPs) by self-assembling with the siRNA resulting in the fully siRNA protection based on its protease resistant peptide sequence. With regard to an in vivo application, we investigated here the influence of the polyethylene glycol (PEG) grafting to RICK NPs on their in vitro and in vivo siRNA delivery properties...
April 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28402361/electronic-characterization-of-geobacter-sulfurreducens-pilins-in-self-assembled-monolayers-unmasks-tunnelling-and-hopping-conduction-pathways
#19
Krista M Cosert, Rebecca J Steidl, Angelines Castro-Forero, Robert M Worden, Gemma Reguera
The metal-reducing bacterium Geobacter sulfurreducens produces protein nanowires (pili) for fast discharge of respiratory electrons to extracellular electron acceptors such as iron oxides and uranium. Charge transport along the pili requires aromatic residues, which cluster once the peptide subunits (pilins) assemble keeping inter-aromic distances and geometries optimal for multistep hopping. The presence of intramolecular aromatic contacts and the predominantly α-helical conformation of the pilins has been proposed to contribute to charge transport and rectification...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28400129/the-ph-dependent-assembly-of-chaplin-e-from-streptomyces-coelicolor
#20
Mina Dokouhaki, Andrew Hung, Li Day, Sally L Gras
Chaplin E, is one of five self-assembling peptides secreted by Streptomyces coelicolor that assist aerial growth by lowering the surface tension of water. Although the surface activity of a mixture of chaplin peptides has observed to depend on pH, it is unclear how the solvent environment (i.e. pH) influences the structure, assembly and subsequent functionality of these individual peptides. In this study, the conformation and fibril forming propensity of the Chaplin E peptide was assessed as a function of pH using a combination of experimental measurements and molecular dynamics simulations...
April 8, 2017: Journal of Structural Biology
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