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C Miossec, V Dutilleul, L Durand, C Faucheu, L Pilatre, J Golec, F Fassy, A Diu-Hercend
IL-1beta converting enzyme (ICE) and ICE-related proteases (IRPs) have been suggested to play a central role in apoptosis. We report the use of peptidic ICE inhibitors to reassess the role of this enzyme in the apoptosis induced by Fas or TNFalpha receptor ligation in Jurkat cells, U937 cells or monocytes. Our results show that inhibition of IL-1beta processing can be dissociated from inhibition of apoptosis. Indeed, two out of three com-pounds active on ICE are not inhibitory for apoptosis. This shows that ICE is not required for progression in the apoptotic pathway, but that one or several IRPs are necessary...
1997: Apoptosis: An International Journal on Programmed Cell Death
No abstract text is available yet for this article.
April 1953: Medicamenta
C Miossec-Bartoli, L Pilatre, P Peyron, E N N'Diaye, V Collart-Dutilleul, I Maridonneau-Parini, A Diu-Hercend
HMR3647 is a semisynthetic representative of a new group of drugs, the ketolides, derived from erythromycin A. Since macrolides have been shown to accumulate in human polymorphonuclear cells (PMNs), we have investigated the ability of the molecule HMR3647 to enter human PMNs as well as other cell types, such as peripheral blood mononuclear cells and cell lines of hematopoietic and nonhematopoietic origin. In these experiments, HMR3647 was compared to erythromycin A, azithromycin, clarithromycin, and roxithromycin...
October 1999: Antimicrobial Agents and Chemotherapy
M A Shampo, R A Kyle
No abstract text is available yet for this article.
April 22, 1983: JAMA: the Journal of the American Medical Association
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