C Miossec-Bartoli, L Pilatre, P Peyron, E N N'Diaye, V Collart-Dutilleul, I Maridonneau-Parini, A Diu-Hercend
HMR3647 is a semisynthetic representative of a new group of drugs, the ketolides, derived from erythromycin A. Since macrolides have been shown to accumulate in human polymorphonuclear cells (PMNs), we have investigated the ability of the molecule HMR3647 to enter human PMNs as well as other cell types, such as peripheral blood mononuclear cells and cell lines of hematopoietic and nonhematopoietic origin. In these experiments, HMR3647 was compared to erythromycin A, azithromycin, clarithromycin, and roxithromycin...
October 1999: Antimicrobial Agents and Chemotherapy