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Martin Schweiger, Brian Stiasny, F Immer, Christoph Bürki, M Schmiady, Hitendu Dave, Anna Cavigelli-Brunner, Oliver Kretschmar, Vincenzo Cannizzaro, Michael Hübler
Twenty-four percent of pediatric heart transplantations (pHTx) are carried out in infants. Neonatal heart transplantation is both rarely performed and challenging. We report on a newborn baby girl suffering from cardiac failure due to a huge tumor (24x52 mm) within the free wall of the left ventricle (LV) and subtotal obstruction of the main left bronchus. Following a surgical tumor resection, a Berlin Heart EXCOR left ventricular assist device was implanted as the bridge to the transplantation. In spite of an organ donor/recipient mismatch of >200%, both heart transplantation and the post-operative course were successful...
February 24, 2017: Clinical Transplantation
Arwa Kurabi, Kerry A Beasley, Lisa Chang, James McCann, Kwang Pak, Allen F Ryan
Otitis media (OM) is the most common infectious disease of children under six, causing more antibiotic prescriptions and surgical procedures than any other pediatric condition. By screening a bacteriophage (phage) library genetically engineered to express random peptides on their surfaces, we discovered unique peptides that actively transport phage particles across the intact tympanic membrane (TM) and into the middle ear (ME). Herein our goals were to characterize the physiochemical peptide features that may underlie trans-TM phage transport; assess morphological and functional effects of phage peptides on the ME and inner ear (IE); and determine whether peptide-bearing phage transmigrate from the ME into the IE...
2017: PloS One
C Honoré, V Atallah, O Mir, D Orbach, G Ferron, C LePéchoux, J B Delhorme, P Philippe-Chomette, S Sarnacki, S Msika, P Terrier, O Glehen, H Martelli, V Minard-Colin, F Bertucci, J Y Blay, S Bonvalot, D Elias, A LeCesne, P Sargos
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, French Sarcoma Clinical Network and French Pediatric Cancer Society...
2017: PloS One
Grace Wu, Alec Wollen, Stephen Himley, Glenn Austin, Jaclyn Delarosa, Rasa Izadnegahdar, Amy Sarah Ginsburg, Darin Zehrung
BACKGROUND: Continuous oxygen treatment is essential for managing children with hypoxemia, but access to oxygen in low-resource countries remains problematic. Given the high burden of pneumonia in these countries and the fact that flow can be gradually reduced as therapy progresses, oxygen conservation through routine titration warrants exploration. AIM: To determine the amount of oxygen saved via titration during oxygen therapy for children with hypoxemic pneumonia...
2017: PloS One
Atul Malhotra, Michael Ditchfield, Michael C Fahey, Margie Castillo-Melendez, Beth J Allison, Graeme R Polglase, Euan M Wallace, Ryan Hodges, Graham Jenkin, Suzanne L Miller
Fetal growth restriction (FGR) is a common complication of pregnancy and, in severe cases, is associated with elevated rates of perinatal mortality, neonatal morbidity, and poor neurodevelopmental outcomes. The leading cause of FGR is placental insufficiency, with the placenta failing to adequately meet the increasing oxygen and nutritional needs of the growing fetus with advancing gestation. The resultant chronic fetal hypoxia induces a decrease in fetal growth, and a redistribution of blood flow preferentially to the brain...
February 24, 2017: Pediatric Research
Amir H Dorafshar, Edward H Davidson, Paul N Manson
No abstract text is available yet for this article.
March 2017: Plastic and Reconstructive Surgery
Natalia I Ziolkowski, Leanne Zive, Emily S Ho, Ronald M Zuker
BACKGROUND: Pediatric forearm compartment syndrome can lead to severe functional disability. Although it is known that earlier presentation with decompression leads to better outcomes, it is not known when presentation after injury leads to significant loss of function requiring microsurgical intervention. The authors describe the rate of microsurgical reconstruction after pediatric forearm compartment syndrome as related to timing of presentation. METHODS: A retrospective chart review was conducted of pediatric patients with forearm compartment syndrome between January 1, 2000, and March 22, 2013, after a traumatic upper extremity injury...
March 2017: Plastic and Reconstructive Surgery
Geneviève Du Pont-Thibodeau, Sarah M Sanchez, Abbas F Jawad, Vinay M Nadkarni, Robert A Berg, Nicholas S Abend, Alexis A Topjian
OBJECTIVES: Determine the accuracy and confidence of critical care medicine providers to identify seizures using amplitude-integrated electroencephalography versus amplitude-integrated electroencephalography combined with color density spectral array electroencephalography (aEEG + CDSA). DESIGN: Tutorial and questionnaire. SETTING: PICU. SUBJECTS: Pediatric critical care providers (attendings, fellows, and nurses). INTERVENTIONS: A standardized powerpoint tutorial on amplitude-integrated electroencephalography and color density spectral array followed by classification of 100 amplitude-integrated electroencephalography images and 100 amplitude-integrated electroencephalography combined with color density spectral array as displaying seizures or not displaying seizures...
February 23, 2017: Pediatric Critical Care Medicine
Dazhi Liu, Brian Seyboth, Sherry Mathew, Stephen W Gilheeney, Alexander J Chou, Esther Drill, Rachel Kobos
BACKGROUND: Palifermin has been proven to decrease the frequency of severe oral mucositis in adult patients with sarcoma and metastatic colorectal cancer receiving chemotherapy. The impact of palifermin on the incidence of mucositis in nonhematopoietic stem cell transplantation (HSCT) pediatric population receiving chemotherapy has never been reported to date. PATIENTS AND METHODS: This is a retrospective analysis of pediatric patients who received palifermin as secondary prophylaxis to prevent chemotherapy-induced mucositis at Memorial Sloan Kettering Cancer Center from January 1, 2008 to 2014...
February 23, 2017: Journal of Pediatric Hematology/oncology
Hanan F Nazir, Mohamed Elshinawy, Abdulhakim AlRawas, Doaa Khater, Sherin Zadjaly, Yasser Wali
STUDY OBJECTIVE: To study dapsone in comparison with trimethoprim/sulfamethoxazole (TMP/SMX) for Pneumocystis jiroveci (PJP) prophylaxis in children with acute lymphoblastic leukemia (ALL). DESIGN: A retrospective study with a prospective follow-up. PATIENTS: Pediatric ALL patients diagnosed between May 2009 and May 2014, who are still receiving or have completed their maintenance chemotherapy. Patients who completed chemotherapy were prospectively followed up for neutropenia...
February 23, 2017: Journal of Pediatric Hematology/oncology
Anirban Das, Indranil Mallick, Pattatheyil Arun, Divya Midha, Saugata Sen, Shekhar Krishnan, Arpita Bhattacharyya
No abstract text is available yet for this article.
February 23, 2017: Journal of Pediatric Hematology/oncology
Suha Al Omar, Nadine Anabtawi, Wiam Al Qasem, Rawad Rihani
BACKGROUND: The aim of the study was to describe the incidence and type of bacterial infections associated with the use of ciprofloxacin prophylaxis as single agent in pediatric patients with acute myeloid leukemia (AML). PROCEDURE: This was a retrospective review of all patients with AML, who were treated according to the AML02 protocol between 2011 and 2015. The medical records were reviewed for any positive cultures from the initiation of the protocol until death or protocol discontinuation...
February 23, 2017: Journal of Pediatric Hematology/oncology
Ugur Demirsoy, Nazan Sarper, Sema Aylan Gelen, Emine Zengin, Tugba Kum, Hakan Demir
AIM: To investigate the association of calcium (Ca) and vitamin D (vit D) supplementation with bone mineral density (BMD) in pediatric acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: Group I (n=11): de novo ALL patients aged 1 to 18 years. Group II (n=46): pediatric ALL survivors in first complete remission and ALL patients on maintenance chemotherapy. We stratified group II into 3 subgroups according to the postdiagnosis period (group IIa: 8 to 24 mo, group IIb: 24 to 48 mo, group IIc: >48 mo)...
February 23, 2017: Journal of Pediatric Hematology/oncology
Eileen A Crawford, Laura J Young, Asheesh Bedi, Edward M Wojtys
BACKGROUND: Although studies have shown increased rates of chondral injury with delayed surgical treatment of pediatric anterior cruciate ligament (ACL) injuries, it is unknown if this is related to a delay in diagnosis and appropriate activity restrictions. The purpose of this study was to determine if the time from injury to diagnosis, time from diagnosis to reconstruction, and preoperative activity level correlate with the degree of cartilage injury seen intraoperatively. METHODS: A retrospective review of skeletally immature patients who underwent ACL reconstruction was performed...
February 23, 2017: Journal of Pediatric Orthopedics
James G Carlucci, Meridith Blevins, Aaron M Kipp, Mary Lou Lindegren, Quy Tuan Du, Lorna Renner, Gary Reubenson, John Ssali, Marcel Yotebieng, Anna M Mandalakas, Mary-Ann Davies, Marie Ballif, Lukas Fenner, April C Pettit
INTRODUCTION: Management of tuberculosis (TB) is challenging in HIV/TB co-infected children. The World Health Organization (WHO) recommends nucleic acid amplification tests for TB diagnosis, a four-drug regimen including ethambutol during intensive phase of treatment (IP), and initiation of antiretroviral therapy (ART) within eight weeks of TB diagnosis. We investigated TB treatment outcomes by diagnostic modality, IP regimen, and ART status. METHODS: We conducted a retrospective cohort study among HIV/TB co-infected children enrolled at International Epidemiology Databases to Evaluate AIDS treatment sites from 2012-2014...
February 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Corinna Hirzinger, Christian Heil, Roman Metzger, Denis D Bensard
No abstract text is available yet for this article.
February 23, 2017: Journal of Trauma and Acute Care Surgery
Robert D B Jaquiss, Tilman Humpl, Charles E Canter, David L S Morales, David N Rosenthal, Charles D Fraser
The Berlin Heart EXCOR Pediatric Ventricular Assist Device (BH) was approved for use in the United States in December 2011, based on a prospective investigational device exemption (IDE) trial. Strict exclusion criteria for the trial selected a low-risk "ideal" cohort. We sought to determine whether postapproval usage of the BH in a "real world" cohort of recipients would result in similar outcomes. Preimplant diagnostic information was collected for all patients. Efficacy was evaluated by comparison of all children (efficacy group, n = 247) implanted between FDA approval and April 2015 to those in the IDE trial (IDE, n = 48), with regard to achievement of one of four end-states: transplanted, successful weaning, death/unsuccessful weaning, or still-on-device...
March 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Judy A Beal
No abstract text is available yet for this article.
March 2017: MCN. the American Journal of Maternal Child Nursing
Annika Mutanen, Jouko Lohi, Päivi Heikkilä, Hannu Jalanko, Mikko P Pakarinen
OBJECTIVE: Although liver disease is a major complication of parenteral nutrition (PN) for intestinal failure (IF), its pathogenesis remains unclear. We investigated potential molecular mechanisms of liver injury in pediatric onset IF. METHODS: Liver expression of canalicular phospholipid (ABCB4), bile acid (ABCB11), and sterol (ABCG5/8) transporters, their upstream regulators LXR and FXR as well as pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor (TNF) were investigated among patients with IF [age median 3...
February 23, 2017: Annals of Surgery
Gregory Hansen, Darcy L Beer, Jeff K Vallance
INTRODUCTION: Although the interfacility transport (IFT) of critically ill pediatric patients from rural to tertiary health centres may improve outcomes, the impact of IFTs on the rural referring centre is not known. The purpose of this study was to investigate how the IFT of critically ill children affects staffing and functionality of rural emergency departments (EDs) in Manitoba. METHODS: In 2015, surveys were emailed to the medical directors of all 15 regional EDs within 2 hours' travel time from a tertiary pediatric hospital...
2017: Canadian Journal of Rural Medicine
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