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https://www.readbyqxmd.com/read/29684801/evaluation-of-racial-disparities-in-pediatric-optic-pathway-glioma-incidence-results-from-the-surveillance-epidemiology-and-end-results-program-2000-2014
#1
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. METHODS: OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino")...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#2
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684480/fetuin-b-links-vitamin-d-deficiency-and-pediatric-obesity-direct-negative-regulation-by-vitamin-d
#3
Gillian E Walker, Antonia Follenzi, Valentina Bruscaggin, Marcello Manfredi, Simonetta Bellone, Emilio Marengo, Luigi Maiuri, Flavia Prodam, Gianni Bona
Vitamin D (VD) deficiency (VDD) correlates to obesity, with VD a recognized mediator of metabolic diseases. From a previous proteomic study identifying adiponectin as a link between VDD and pediatric obesity, herein we analysed another protein (SSP2301) increased with VDD. A focused 2D-electrophoretic analysis identified 4 corresponding plasma proteins, with one predicted to be fetuin B (FETUB). FETUB was studied due to its emerging role in metabolic diseases and cytogenetic location (3q27.3) with adiponectin...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29684375/cumulative-effect-of-preoperative-risk-factors-on-mortality-after-pediatric-heart-transplantation
#4
Matthew J O'Connor, Andrew C Glatz, Joseph W Rossano, Robert E Shaddy, Rachel Ryan, Chitra Ravishankar, Stephanie Fuller, Christopher E Mascio, J William Gaynor, Kimberly Y Lin
BACKGROUND: Risk assessment in heart transplantation is critical for candidate selection, but current models inadequately assess individual risk of postoperative mortality. We sought to identify risk factors and develop a scoring system to predict mortality following heart transplantation in children. METHODS: The records of patients undergoing heart transplantation at our institution from 2010 - 2016 were reviewed. Clinical characteristics were recorded and compared between survivors and non-survivors...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684318/does-size-matter-when-calculating-the-correct-tidal-volume-for-pediatric-mechanical-ventilation-a-hypothesis-based-on-forced-vital-capacity
#5
Gina J Kim, Christopher J L Newth, Robinder G Khemani, Suzy L Wong, Allan L Coates, Patrick A Ross
BACKGROUND: Tidal volumes standardized to predicted body weight are recommended for adult mechanical ventilation, but children are frequently ventilated using measured body weight. Our goal is to examine the difference in forced vital capacity (FVC ml/kg) using measured compared to predicted body weight in children. METHODS: Retrospective analysis of outpatient pulmonary function tests (PFTs) from two datasets. Dataset one: 6 to 19 year old children undergoing PFTs from the nationally-representative Canadian Health Measures Survey...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684226/iris-hypoplasia-as-the-presenting-sign-of-retinoblastoma-in-a-child-with-a-13q-deletion
#6
Sona Shah, Yaran Koban, Bao Han A Le, Mercy Bechtold, Emily Zolfaghari, Jonathan W Kim, Jesse L Berry
Germline partial chromosomal deletions of the entire RB1 gene (13q deletions), account for 6% of the RB1 mutational spectrum. The authors report the rare case of one patient with suspected bilateral iris heterochromia who actually had iris hypoplasia (often masquerading as heterochromia) and bilateral retinoblastoma, due to 13q deletion syndrome. [J Pediatr Ophthalmol. 2018;55:e10-e13.].
April 23, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29684225/primary-intraocular-malignant-rhabdoid-tumor-without-extrascleral-compromise
#7
Eva Ayala Barroso, Alejandra Tapia Bahamondes, Juan Carlos Sánchez España, Llúcia Alós, Ramón Medel Jiménez
Primary intraocular malignant rhabdoid tumor is classified as a malignant extrarenal rhabdoid tumor. It is extremely rare, highly aggressive, and, so far, only one case (in a newborn) has been described in the medical literature. The authors report a second case of primary intraocular malignant rhabdoid tumor, this time without extrascleral involvement and in a teenager, and describe its histological, immunohistochemical, and radiological characteristics along with clinical correlations. [J Pediatr Ophthalmol...
April 23, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29684000/split-liver-transplantation-and-pediatric-waitlist-mortality-in-the-united-states-potential-for-improvement
#8
Emily R Perito, Garrett Roll, Jennifer L Dodge, Sue Rhee, John P Roberts
BACKGROUND: In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS: Using UNOS STAR data, we identified livers transplanted 2010-2015 that could potentially have been used for split transplant, based on strict criteria. Livers not suitable for pediatric patients or allocated to high-risk recipients were excluded...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683960/excessive-treatment-failures-in-patients-with-parameningeal-rhabdomyosarcoma-with-reduced-dose-cyclophosphamide-and-delayed-radiotherapy
#9
John T Lucas, Alberto S Pappo, Jianrong Wu, Daniel J Indelicato, Matthew J Krasin
Pediatric patients with parameningeal rhabdomyosarcoma and high-risk features are recommended to receive radiotherapy at initiation of protocol therapy due to concerns about the increased risk of local and leptomeningeal failure from treatment delay. We report our early experience on a multi-institutional prospective trial incorporating delayed primary site radiation and reduced dose cyclophosphamide in all patients with parameningeal tumors. We observed an excessive number of locoregional treatment failures following this approach and have subsequently amended our trial to move radiation therapy upfront for those patients with high-risk features...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683958/kidney-protective-effect-of-magnesium-supplementation-in-cisplatin-containing-chemotherapy-for-pediatric-cancer-a-retrospective-study
#10
Motohiro Matsui, Yuya Saito, Shoko Yamaoka, Yuichi Yokokawa, Yoshihiko Morikawa, Atsushi Makimoto, Yuki Yuza
In total, 158 chemotherapy courses containing cisplatin for 37 pediatric cases of newly diagnosed cancer were divided into 2 groups depending on whether magnesium (Mg) supplementation was administered (Mg+: 92 courses) or not (Mg-: 66 courses). Renal impairment was defined as grade 2 or higher creatinine elevation (CE) after each chemotherapy course. The incidence of CE in the Mg+ was significantly lower than in the Mg- (9.8% vs. 22.7%; P=0.025). Multivariate analysis revealed that Mg supplementation significantly reduced the incidence of CE (odds ratio, 0...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683949/a-rare-case-of-hemophagocytic-lymphohistiocytosis-associated-with-myelodysplastic-syndrome-and-trisomy-8-in-a-pediatric-patient
#11
Seh Hyun Kim, Dae Yong Yi, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim
Hemophagocytic lymphohistiocytosis (HLH) is a rare disease resulting in clinical and biochemical manifestations of extreme inflammation. Myelodysplastic syndrome (MDS) represents a heterogenous group of clonal hematopoietic disorders. The development of MDS is common in children with trisomy of chromosome 8. Here, we report a fatal case of 8-year-old girl who was admitted to the emergency department with status epilepticus, and later diagnosed with HLH associated with MDS and trisomy of chromosome 8. We believe this is the first reported case of HLH associated with MDS and trisomy 8 in a pediatric patient...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683945/ebv-related-cold-agglutinin-disease-presenting-with-conjugated-hyperbilirubinemia-a-pediatric-case-report-and-mini-review
#12
Elpis Mantadakis, Eleftherios Chatzimichael, Eftychia Kontekaki, Maria Panopoulou, Georges Martinis, Aggelos Tsalkidis
Hemolytic anemia occurs in only 1% to 3% of hospitalized patients with infectious mononucleosis. The authors describe an 8-year-old girl without cervical lymphadenopathy or splenomegaly, who presented with conjugated hyperbilirubinemia and was diagnosed with cold agglutinin disease caused by an immunoglobulin M autoantibody with anti-i specificity. Acute Epstein-Barr virus infection was confirmed by serological and molecular methods. She recovered uneventfully after a 3-week course of methylprednisolone. Epstein-Barr virus infection should be considered in any case of hemolytic anemia associated with hepatic dysfunction, especially when direct antiglobulin test is positive for C3d...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683943/pentoxifylline-added-to-steroid-window-treatment-phase-modified-apoptotic-gene-expression-in-pediatric-patients-with-acute-lymphoblastic-leukemia
#13
Jesus Meza-Arroyo, Alejandro Bravo-Cuellar, Luis Felipe Jave-Suárez, Georgina Hernández-Flores, Pablo Ortiz-Lazareno, Adriana Aguilar-Lemarroy, Marlin Padilla-Corona, Fernando Sanchez-Zubieta, Oscar Gonzalez-Ramella
Pentoxifylline is a xanthine that possesses antitumor properties and that can induce higher apoptosis in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) during treatment with prednisone. We conducted a phase 1 pilot, controlled, randomized trial to evaluate the gene expression modified by pentoxifylline during the steroid window of induction to remission phase in patients newly diagnosed with ALL. Experimental and control treatments induced broad changes in the gene expression profile...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683873/eltrombopag-induced-acute-liver-failure-in-a-pediatric-patient-a-pharmacokinetic-and-pharmacogenetic-analysis
#14
M Marano, J Serafinelli, S Cairoli, D Martinelli, M Pisani, G Palumbo, M G Cefalo, C Cecchetti, M Di Nardo, F S Falvella, B M Goffredo
Eltrombopag is an oral thrombopoietin-receptor-agonist (TPO-RA) approved for the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP), who are more than one year old, and show poor response to first-line therapy. ITP is a hematological disorder characterized by isolated thrombocytopenia in the absence of secondary causes or disorders. Eltrombopag is generally well tolerated in the pediatric population, therefore therapeutic drug monitoring (TDM) is not usually performed in clinical practice...
April 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29683858/the-effect-of-booster-seat-use-on-pediatric-injuries-in-motor-vehicle-frontal-crashes
#15
Sean Caskey, Joshua Hammond, Jeffery Peck, Matthew Sardelli, Theresa Atkinson
BACKGROUND: Motor vehicle crashes are a significant source of pediatric mortality and morbidity. Studies indicate that booster seats significantly improve seat belt fit for children who have not attained a height of 145 cm (4' 9"). This study examined injuries occurring in booster age children up to age 12, as the majority of children do not attain 145 cm until this age. The purpose of the study was to identify differences in injuries due to the type of restraint used, with attention to musculoskeletal injuries...
April 20, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29683818/pan-trk-immunohistochemistry-identifies-ntrk-rearrangements-in-pediatric-mesenchymal-tumors
#16
Erin R Rudzinski, Christina M Lockwood, Bradley A Stohr, Sara O Vargas, Rachel Sheridan, Jennifer O Black, Veena Rajaram, Theodore W Laetsch, Jessica L Davis
Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic nephroma. Traditionally, molecular confirmation of these fusions has included either fluorescent in situ hybridization for ETV6 rearrangements or reverse-transcriptase polymerase chain reaction for the classic ETV6-NTRK3 fusion. However, these methods overlook variant NTRK rearrangements, which are increasingly appreciated as recurrent events in a subset of pediatric mesenchymal tumors...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683814/radiographic-resource-utilization-in-the-initial-referral-and-evaluation-of-patients-with-adolescent-idiopathic-scoliosis
#17
Matthew E Oetgen, Allison L Matthews, Benjamin D Martin, Jeffrey Hanway, Shannon Kelly, Laurel Blakemore
INTRODUCTION: The dangers of radiation exposure in children have been well studied, with assessment of adolescent idiopathic scoliosis (AIS) documented as having the potential for notable patient exposure. The purposes of this study were to evaluate a consecutive series of patients referred to a tertiary care pediatric hospital for AIS and to assess the type and quality of imaging obtained before referral for specialist evaluation. METHODS: We performed a prospective study of consecutive patients referred over a 6-month period to a pediatric orthopaedic practice at a large, free-standing, urban children's hospital for evaluation of AIS...
April 19, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29683728/healthcare-providers-attitudes-and-behaviours-related-to-paediatric-mild-traumatic-brain-injury-results-from-the-2014-docstyles-survey
#18
Kelly Sarmiento, Zoe Donnell, Rosanne Hoffman, Bethany Tennant
OBJECTIVE: Explore healthcare providers' experiences managing mTBI and better understand their use of mTBI assessment tools and guidelines. Cross-sectional Methods: A random sample of 1,760 healthcare providers responded to the web-based DocStyles survey between June 18 and 30, 2014. The sample included family/general practitioners, internists, pediatricians, and nurse practitioners who reported seeing pediatric patients. We examined their experiences with mTBI to identify opportunities to increase preparedness and improve management of mTBI...
April 23, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29683123/pediatric-oncology-nurses-experiences-with-prognosis-related-communication
#19
Amy R Newman, Margaret F Callahan, Stacee M Lerret, Debra L Oswald, Marianne E Weiss
OBJECTIVES: To examine nurses' experiences of prognosis-related communication (PRC) with parents of children with cancer. SAMPLE & SETTING: Cross-sectional, correlational study in the pediatric oncology setting involving 316 members of the Association of Pediatric Hematology/Oncology Nurses. METHODS & VARIABLES: Online survey regarding individual nurse factors, PRC, interprofessional collaboration, moral distress, and perceived quality of care...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29683122/symptoms-and-self-management-strategies-identified-by-children-with-cancer-using-draw-and-tell-interviews
#20
Lauri A Linder, Heather Bratton, Anna Nguyen, Kori Parker, Sarah E Wawrzynski
PURPOSE: This cross-sectional study described how school-aged children with cancer represent their symptoms and associated characteristics using draw-and-tell interviews. PARTICIPANTS & SETTING: 27 children aged 6-12 years receiving treatment for cancer at the Cancer Transplant Center at Primary Children's Hospital, a tertiary pediatric hospital in Salt Lake City, Utah. METHODOLOGIC APPROACH: Children participated in draw-and-tell interviews while completing drawings depicting days when they felt well and days when they felt sick...
May 1, 2018: Oncology Nursing Forum
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