Read by QxMD icon Read


Kazuhiro Uda, Chitose Koyama-Wakai, Kensuke Shoji, Noriyasu Iwase, Daisuke Motooka, Shota Nakamura, Isao Miyairi
BACKGROUND: WU polyomavirus (WUPyV) is a relatively new virus associated with respiratory infections. However, its role is unclear in children with severe respiratory failure. OBJECTIVES: We aimed to evaluate the characteristics of severe respiratory failure associated with WUPyV infection in children. STUDY DESIGN: We retrospectively reviewed cases of respiratory tract infection at a tertiary children's hospital in Japan and performed real-time polymerase chain reaction (PCR) for WUPyV using residual extracted nucleic acid samples taken from respiratory tract samples of pediatric patients primarily with respiratory failure...
August 9, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Matt S Zinter, Kevin L Delucchi, Michele Y Kong, Benjamin E Orwoll, Aaron S Spicer, Michelle J Lim, Mustafa F Alkhouli, Anna E Ratiu, Anne V McKenzie, Patrick S McQuillen, Christopher C Dvorak, Carolyn S Calfee, Michael A Matthay, Anil Sapru
RATIONALE: Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) may contribute to lung injury through extracellular matrix degradation and modulation of inflammation and fibrosis. OBJECTIVES: To test for an association between MMP pathway proteins and inflammation, endothelial dysfunction, and clinical outcomes. METHODS: We measured MMPs in plasma collected on ARDS day 1 from 235 children at 5 hospitals between 2008-2017...
August 16, 2018: American Journal of Respiratory and Critical Care Medicine
Yoshihiro Yonekawa, Howard F Fine
No abstract text is available yet for this article.
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Hitoshi Tajiri, Satoshi Motoya, Fukunori Kinjo, Atsuo Maemoto, Takayuki Matsumoto, Noriko Sato, Hiroshi Yamada, Mieko Nagano, Yutaka Susuta, Kunihiko Ozaki, Kazuoki Kondo, Toshifumi Hibi
OBJECTIVES: The prevalence of pediatric Crohn's disease (CD) is increasing in Japan and other countries, and many patients are unresponsive to or do not tolerate current treatment options. This study aimed to investigate the efficacy, safety, and pharmacokinetic profile of infliximab (IFX) in pediatric patients with moderate-to-severe CD and inadequate response to existing treatment. STUDY DESIGN: This was an open-label, uncontrolled, multicenter Phase 3 study conducted at nine sites in Japan between April 2012 and March 2015...
2018: PloS One
Amir Taher, Benjamin Zhu, Sophia Ma, Albert Shun, Anne M Durkan
BACKGROUND: The incidence and types of intraabdominal complications following pediatric transplantation are not well established and specific risk groups have not been clearly identified. METHODS: A retrospective chart review of all pediatric transplant recipients, between 1995 and 2016 was undertaken. Intraabdominal complications were grouped into 4 categories: fluid collections, gastrointestinal, vascular and urogenital. Donor, recipient, and transplant characteristics were evaluated using univariate and multivariate logistic regression...
August 15, 2018: Transplantation
Lei Tong, Mingjing Li, Fan Li, Jian Xu, Tao Hu
The aim of this study was to analyze the management of displaced intra-articular calcaneal fractures in children at our pediatric orthopedic and to determine the results following open reduction via minimally invasive sinus tarsi approach and fixation with Kirschner wires (K-wires). Overall, 25 available cases of calcaneal fractures in children with mean age of 9.8 years were treated by open reduction from January 2010 to December 2015. All patients were followed up from 12 to 30 months (mean: 19 months). Clinical functional outcomes were graded using the American Orthopedic Foot and Ankle Society hindfoot scores...
August 15, 2018: Journal of Pediatric Orthopedics. Part B
Xuechen Xiong, Shuai Zhou, Zhaohua Huo, Li Luo
BACKGROUND: To improve the utilization efficiency of health care services, the concept of a "regional medical consortium" has attracted more attention during the most recent round of health care reform in China. Shanghai, a municipality of China, has made many efforts to promote its regional medical consortium project. In this paper, the pediatric medical consortium of Shanghai will serve as an example to introduce the main tasks and groundwork of the Shanghai medical consortium and will underscore Shanghai's exploration of the vertical integration of medical resources...
August 16, 2018: International Journal of Health Planning and Management
Sean T O'Leary, James D Campbell, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (J...
August 2, 2018: Journal of the Pediatric Infectious Diseases Society
Angeliki Makri, Srivandana Akshintala, Claudia Derse-Anthony, Jaydira Del Rivero, Brigitte Widemann, Constantine A Stratakis, John Glod, Maya Lodish
Background: Multiple endocrine neoplasia type 2B (MEN2B) is characterized by early-onset medullary thyroid cancer (MTC) in virtually all cases and a 50% lifetime risk of pheochromocytoma (PHEO) development. The literature on PHEO in patients with MEN2B is limited with most data being reported from adult studies that primarily address MEN2A. Aim: The aim of the current study is to describe PHEO development in a cohort of pediatric patients with MEN2B. Design: Retrospective chart review of patients with MEN2B evaluated at the NIH in the period between July 2007 and February 2018...
August 2, 2018: Journal of Clinical Endocrinology and Metabolism
E S Garbaruk, M V Goykhburg, A Warzybok, G A Tavartkiladze, P V Pavlov, B Kollmeier
Identification and diagnostics of auditory processing disorders (APD) in the children continues to be a challenge. Screening tools help to decide the need for evaluation. However, none of them are used routinely in Russia, nor are there thus far auditory checklist questionnaires in the Russian language. The aim of his study was to approve Children's Auditory Performance Scale (CHAPS) and Fisher's Auditory Checklist in Russian for the children at the age of 5-10 years. The study included 52 children at the age from 5 to 11 years...
2018: Vestnik Otorinolaringologii
Terra Watkins, Shelia Keller
The objectives of this scoping review are: to explore existing literature related to discharge criteria, guidelines and protocols from hospitals or clinics that are being implemented for home oxygen therapy (HOT) in the management of hypoxia in pediatric patients with acute bronchiolitis, examine and conceptually map the evidence, and identify any gaps in the literature.The question of this review is: what discharge criteria, guidelines, and protocols are used for HOT in the management of hypoxia in pediatric patients with acute bronchiolitis?...
August 2018: JBI Database of Systematic Reviews and Implementation Reports
Jordana Goldman, Moreshwar S Desai, Kenneth L McClain, M Hossein Tcharmtchi, Curtis E Kennedy, Kathleen Thompson, Fong Lam, Dalia A Bashir, Ivan K Chinn, Baruch R Goldberg, Carl E Allen, Trung C Nguyen
OBJECTIVES: Hemophagocytic lymphohistiocytosis poses significant challenges due to limited tools to guide clinical decisions in a population at high risk of death. We sought to assess whether disseminated intravascular coagulation and hepatobiliary dysfunction, significant comorbidities seen in critical care settings, would identify hemophagocytic lymphohistiocytosis patients with increased risk of mortality. DESIGN: Retrospective chart review. SETTING: Single-center PICU...
August 14, 2018: Pediatric Critical Care Medicine
Thomas W Conlon, David B Kantor, Erik R Su, Sonali Basu, Donald L Boyer, Bereketeab Haileselassie, Tara L Petersen, Felice Su, Akira Nishisaki
OBJECTIVES: To assess current diagnostic bedside ultrasound program core element (training, credentialing, image storage, documentation, and quality assurance) implementation across pediatric critical care medicine divisions in the United States. DESIGN: Cross-sectional questionnaire-based needs assessment survey. SETTING: Pediatric critical care medicine divisions with an Accreditation Council of Graduate Medical Education-accredited fellowship...
August 14, 2018: Pediatric Critical Care Medicine
Ahmed M Abdelrahman, Yasmine M El Sayed
PURPOSE: To compare the safety and efficacy of micropulse and continuous wave transscleral cyclophotocoagulation for the treatment of refractory glaucoma in the pediatric age group. METHODS: This prospective study included 45 eyes of 36 children requiring transscleral cyclophotocoagulation in the period from September 2016 to August 2017, using micropulse (MP-CPC) or continuous wave (CW-CPC) modes. The IOP reduction, success rates and complications were compared for both groups...
August 14, 2018: Journal of Glaucoma
Janine M Roller, Rebecca J M Courtemanche, Douglas J Courtemanche
BACKGROUND: There has been an exponential increase in the number of patient reported outcome measures, PROMs, in plastic surgery. This study aims to review the reliability, validity, and practicality of the most frequently used PROMs in pediatric plastic surgery research. METHODS: A review of the literature from January 2010 - June 2015 was conducted to identify PROMs in pediatric plastic surgery. PROMs used in 5 articles with 2 validation studies were included for analysis and classified as generic, disease specific, and mental health...
August 11, 2018: Plastic and Reconstructive Surgery
Yusuke Okubo, Kotaro Nochioka, Marcia A Testa
OBJECTIVE: Anaphylaxis is a common, serious, systemic allergic reaction. In the United States, the change of annual hospitalization rates by anaphylaxis-trigger foods and risk factors associated with severity remain unclear. METHODS: Hospital discharge records of food-induced anaphylactic reactions of individuals younger than 20 years were obtained from Kids' Inpatient Database in 2006, 2009, and 2012 and were weighted to estimate the number of hospitalizations in the United States...
August 14, 2018: Pediatric Emergency Care
Max M Feinstein, Anthony E Pannunzio, Samuel Lobell, Eric Kodish
Informed consent for pediatric anesthesia challenges practitioners to navigate complex ethical, medical, and legal ambiguities. A patient's status as a minor does not negate the importance of his or her participation in the decision-making process but, rather, necessitates a nuanced evaluation of age and development to involve the patient to an appropriate extent. Given the complexities involved with pediatric informed consent in anesthesia practice and research, it is important to understand the experience of key stakeholders involved...
August 14, 2018: Anesthesia and Analgesia
Olubukola O Nafiu, Aleda Thompson, S Devi Chiravuri, Benjamin Cloyd, Paul I Reynolds
BACKGROUND: Many children recovering from anesthesia experience pain that is severe enough to warrant intravenous (IV) opioid treatment within moments of admission to the postanesthesia care unit (PACU). Postoperative pain has several negative consequences; therefore, preventing significant PACU pain in children is both a major clinical goal and a moral/ethical imperative. This requires identifying patient-level and perioperative factors that may be used to predict PACU IV opioid requirement...
August 14, 2018: Anesthesia and Analgesia
Luke A Devine, Shiphra Ginsburg, Terese Stenfors, Tulin D Cil, Heather McDonald-Blumer, Catharine M Walsh, Lynfa Stroud
PURPOSE: Although the field of medical education research is growing and residents are increasingly recruited to participate as subjects in research studies, little is known about their experiences. The goal of this study was to explore the experiences and perceptions of residents who are study participants in medical education research. METHOD: A phenomenographic approach was chosen to examine the range of residents' experiences as research participants. A maximum variation sampling strategy was used to identify residents with diverse experiences...
August 14, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Maria E Miscia, Valerio Cecinati, Mario Fusillo, Antonello Persico, Giuseppe Lauriti, Gabriele Lisi, Pierluigi Lelli Chiesa
BACKGROUND: Paratesticular fibrous pseudotumor (PFP) is a rare benign tumor that can mimic malignant tumors; thus, radical orchiectomy was the standard treatment in the past. OBSERVATION: A 15-year-old boy came to our attention for a hard right inguinal swelling. An ultrasound showed a highly vascularized mass. The boy underwent a gonadal-sparing excision of the mass that was diagnosed to be a PFP. The patient recovered well, without recurrences at the follow-up...
August 14, 2018: Journal of Pediatric Hematology/oncology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"