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https://www.readbyqxmd.com/read/28647416/related-factors-of-asymmetrical-vein-sign-in-acute-middle-cerebral-artery-stroke-and-correlation-with-clinical-outcome
#1
Jinchao Yu, Liming Wang, Zhenzhi Li, Shanshan Wang, Guangbin Wang
OBJECTIVE: The aim of our study was to analyze the related factors of asymmetrical cortical vein sign (ACVS) and asymmetrical medullary vein sign (AMVS) on susceptibility-weighted imaging (SWI) in patients with acute middle cerebral artery (MCA) stroke and whether their presence can be used as an independent predictor for clinical outcome. METHODS: According to the presence of ACVS and AMVS on SWI, 124 patients with acute MCA stroke within 3 days were divided into several different groups...
June 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28625574/rapamycin-decreased-blood-brain-barrier-permeability-in-control-but-not-in-diabetic-rats-in-early-cerebral-ischemia
#2
Oak Z Chi, Geza K Kiss, Scott J Mellender, Xia Liu, Harvey R Weiss
Diabetes causes functional and structural changes in blood-brain barrier (BBB). The mammalian target of rapamycin (mTOR) has been associated with glucose metabolism, diabetes, and altering BBB permeability. Since there is only a narrow therapeutic window (3h) for stroke victims, it is important to investigate BBB disruption in the early stage of cerebral ischemia. We compared the degree of BBB disruption in diabetic and in control rats at two hours of reperfusion after one hour of middle cerebral artery (MCA) occlusion with or without inhibition of mTOR...
June 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28620567/a-retrospective-cohort-study-to-assess-patient-and-physician-reported-outcome-measures-after-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-stroke
#3
Sanjay Budhdeo, Angelos G Kolias, David J Clark, Aswin Chari, Peter J Hutchinson, Elizabeth A Warburton
INTRODUCTION: Decompressive hemicraniectomy for malignant middle cerebral artery (MCA) infarction is known to reduce mortality. However, there are on-going concerns in terms of the quality of life in survivors. We aimed to examine the correlation between patient and physician reported outcome measures in decompressive hemicraniectomy. PATIENTS AND METHODS: We analyzed outcomes in 21 patients who underwent decompressive hemicraniectomy for malignant MCA infarction between September 2003 and August 2013 within a regional health system...
May 10, 2017: Curēus
https://www.readbyqxmd.com/read/28611828/heads-up-a-novel-provocative-maneuver-to-guide-acute-ischemic-stroke-management
#4
Latisha K Ali, Julius K Weng, Sidney Starkman, Jeffrey L Saver, Doojin Kim, Bruce Ovbiagele, Brian H Buck, Nerses Sanossian, Paul Vespa, Oh Young Bang, Reza Jahan, Gary R Duckwiler, Fernando Viñuela, David S Liebeskind
BACKGROUND: A common dilemma in acute ischemic stroke management is whether to pursue recanalization therapy in patients with large vessel occlusions but minimal neurologic deficits. We describe and report preliminary experience with a provocative maneuver, i.e. 90-degree elevation of the head of bed for 30 min, which stresses collaterals and facilitates decision-making. METHODS: A prospective cohort study of <7.5 h of acute anterior circulation territory ischemia patients with minimal deficits despite middle cerebral artery (MCA) or internal carotid artery (ICA) occlusive disease...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28608454/accelerated-atherosclerosis-in-anca-associated-vasculitis
#5
I González-Suárez, J J Ríos-Blanco, J Arpa
OBJECTIVES: Cardiovascular disease, including myocardial infarction and stroke, is a major cause of mortality in ANCA-associated vasculitis (AAV). Although AAV affects small vessels, an accelerated atherosclerosis not explained by traditional cardiovascular risk factors (CVRF) has been demonstrated. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cerebral small vessel disease in AAV-patients. MATERIALS & METHODS: Twenty-three AAV-patients in complete remission were recruited...
June 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28604106/decompressive-craniectomy-for-the-treatment-of-malignant-middle-cerebral-artery-infarction
#6
Kapil Mohan Rajwani, Matthew Crocker, Barry Moynihan
INTRODUCTION: Malignant middle cerebral artery (MCA) infarction is associated with up to 80% mortality in the first week, despite maximal medical therapy. Decompressive craniectomy (DC) has been shown to improve survival rates in these patients. However, there are concerns that DC prolongs poor quality of life by increasing the number of survivors with major disability. This review will assess if DC in patients with malignant MCA infarction improves functional outcomes compared to maximal medical therapy...
June 12, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28579508/decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-stroke-south-asian-experience
#7
Saadat Kamran, Naveed Akhtar, Abdul Salam, Ayman Alboudi, Hiba Rashid, Kainat Kamran, Rabia Ali Khan, Mohsin Khalid Mirza, Arsalan Ahmed, Ahmed M A Own, Sohail Al Rukun, Jihad Inshasi, Dirk Deleu, Ghanim Al Sulaiti, Ashfaq Shuaib
BACKGROUND: The randomized trials showed improved outcome and reduced mortality in malignant middle cerebral artery (MMCA) undergoing Decompressive hemicraniectomy (DHC) within 48 hours of stroke onset. Despite high prevalence of stroke, especially in younger individuals, high and short-term mortality from stroke in South Asian and Middle East, there is little published data on DHC in patients with MMCA stroke. METHODS: This is a retrospective, multicenter cross-sectional study to measure outcome following DHC using the modified Rankin Scale (mRS) and dichotomized as favorable (mRS ≤ 4) or unfavorable (mRS > 4), at 3 months...
June 1, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28549641/treatment-of-moyamoya-disease-and-unruptured-intracranial-aneurysm-in-floating-harbor-syndrome-a-case-report
#8
Daniel J Coughlin, Charles A Miller, A Jesse Schuette
BACKGROUND: This is the first report of the successful treatment of moyamoya disease (MMD) and an unruptured intracranial aneurysm in a patient with Floating-Harbor Syndrome (FHS). CASE DESCRIPTION: A 35 year-old, phenotypically syndromic woman presented with signs and symptoms consistent with ischemic stroke. MRI and catheter angiography confirmed diagnosis of moyamoya and a 6 mm basilar apex artery aneurysm (BAA). She underwent right sided craniotomy for direct and indirect revascularization by means of superficial temporal artery-middle cerebral artery (STA-MCA) bypass and encephalo-duro-arterio-synangiosis (EDAS)...
May 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28536522/a-high-resolution-mri-study-of-relationship-between-remodeling-patterns-and-ischemic-stroke-in-patients-with-atherosclerotic-middle-cerebral-artery-stenosis
#9
Dan-Feng Zhang, Yu-Chen Chen, Huiyou Chen, Wei-Dong Zhang, Jun Sun, Cun-Nan Mao, Wen Su, Peng Wang, Xindao Yin
Purpose: Recently, high-resolution magnetic resonance imaging (HR-MRI) has been used to depict the wall characteristics of the intracranial arteries. The aim of this study was to explain the relationship between the remodeling patterns and acute ischemic stroke in patients with atherosclerotic middle cerebral artery (MCA) stenosis using HR-MRI. Materials and Methods: From August 2015 to May 2016, we prospectively screened 33 consecutive patients with unilateral MCA stenosis using time-to-flight MR angiography, including 15 patients with symptomatic MCA stenosis and 18 patients with asymptomatic MCA stenosis...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28530158/analyzing-circle-of-willis-blood-flow-in-ischemic-stroke-patients-through-3d-stroke-arterial-flow-estimation
#10
Aichi Chien, Fernando Viñuela
Background The objective of ischemic stroke (IS) treatment is to achieve revascularization in cerebral arteries to restore blood flow. However, there is no available method to extract arterial flow data from clinical CTA images. We developed 3D Stroke Arterial Flow Estimation (SAFE), which provides blood flow data throughout the Circle of Willis based on 3D CTA and allows comparison of arterial flow distribution in the brain. Methods We implemented a newly developed 3D vascular reconstruction algorithm for clinical stroke CTA images...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28522756/influence-of-sex-menstrual-cycle-and-oral-contraceptives-on-cerebrovascular-resistance-and-cardiorespiratory-function-during-valsalva-or-standing
#11
Syed Abidi, Misha Nili, Stephania Serna, Simon Kim, Christopher Hazlett, Heather Edgell
Women experience orthostatic intolerance more than men, and experience faintness more in the early follicular (i.e. low hormone (LH)) compared to the luteal (i.e. high hormone (HH)) phase of the menstrual cycle. Men (n=13, age: 25.8±1.8) and women in the LH (day 2-5; placebo) and HH) (day 18-24; high dose) phases of the menstrual cycle with (OC; n=14, age: 22.0±0.8) or without oral contraceptives (NOC; n=12, age: 21.8±0.5) underwent the Valsalva maneuver and a supine-sit-stand protocol. Blood pressure, normalized stroke volume (SVi), cardiac output index (Qi), heart rate (HR), end-tidal carbon dioxide (ET-CO2), and middle cerebral artery blood velocity (MCA) were measured...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28522230/cortical-microinfarcts-in-patients-with-middle-cerebral-artery-stenosis
#12
Xinyi Leng, Hui Fang, Yuehua Pu, Xinying Zou, Yuesong Pan, Yannie O Y Soo, Yuming Xu, Chunxue Wang, Xingquan Zhao, Yilong Wang, Yongjun Wang, David S Liebeskind, Lawrence K S Wong, Thomas W Leung, Liping Liu
BACKGROUND: Cortical microinfarcts (CMIs) have been correlated to cognitive decline and dementia. It was previously considered only visible on microscope, but was recently reported to be visible on 3.0 Tesla magnetic resonance imaging (MRI) and linked to presence of intracranial stenosis. We aimed to investigate CMIs on 3.0 Tesla MRI in patients with M1 middle cerebral artery (MCA-M1) stenosis. METHODS: Patients with a recent non-cardioembolic ischemic stroke or transient ischemic attack and an atherosclerotic MCA-M1 stenosis were recruited...
May 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28506000/therapeutic-effects-of-oral-dimethyl-fumarate-on-stroke-induced-by-middle-cerebral-artery-occlusion-an-animal-experimental-study
#13
Anahid Safari, Mehdi Fazeli, Mohammad Reza Namavar, Nader Tanideh, Peyman Jafari, Afshin Borhani-Haghighi
BACKGROUND: Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE: To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS: 22 Sprague-Dawley male rats weighing 275-300 g were randomized into three groups by block randomization. In the sham group (n = 7), the neck was opened, but neither MCA was occluded, nor any drug was administered...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28479590/cerebral-granulomatous-inflammation-secondary-to-hydrophilic-polymer-embolization-following-thrombectomy
#14
Craig Meiers, Yoftahe Abebe, Neville M Alberto, John Riedinger, Dane A Breker, Michael Manchak, Alexander Drofa, Corey Teigen
BACKGROUND Given the recent completion of multiple trials demonstrating the benefit of endovascular mechanical thrombectomy for select patients with proximal large artery occlusive ischemic strokes, there has been a large increase in the performance of these procedures. In the context of increased thrombectomy performance, there have also been increased reports of rare occurrences of granulomatous inflammatory response to the hydrophilic polymer which coat many of these interventional devices. CASE REPORT A 59-year-old female presented with a complete occlusion of her right proximal middle cerebral artery (MCA) and imaging showed a large area of penumbra...
May 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28468691/language-representation-following-left-mca-stroke-in-children-and-adults-an-fmri-study
#15
Robyn Westmacott, Mary Pat McAndrews, Gabrielle deVeber
BACKGROUND: In this case series, functional magnetic resonance imaging was used to examine brain networks that mediate different aspects of language function in 4 young adults (17-22 years) with a history of left middle cerebral artery (MCA) stroke in childhood (40 years of age). Although it is widely believed that altered lateralization patterns are more likely to occur following early brain injuries compared with later brain injuries, the presumed plasticity of the young brain has been challenged in recent years, particularly in the domain of language...
May 4, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28457859/clinical-and-radiological-assessment-of-cerebral-hemodynamics-after-cranioplasty-for-decompressive-craniectomy-a-clinical-study
#16
Perikal J Parichay, Kiran Khanapure, Krishna C Joshi, T J Aniruddha, M Sandhya, A S Hegde
OBJECTIVES: To find the correlation between radiologically proven improvement in cerebral hemodynamics with clinical improvement in patients undergoing cranioplasty. MATERIAL AND METHODS: The study is a prospective observational study of 10 cases, in M S Ramaiah Institute of Neurosciences, involving patients treated by a decompressive craniectomy for intractable intra cranial hypertension either due to trauma or stroke and afterwards underwent cranioplasty. RESULTS: Of the 10 patients, 70% patients showing significant improvement in motor functions on Barthel index scale, 60% patients showed improvement in speech, mean duration from date of decompressive craniectomy to cranioplasty being 122...
April 27, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28450677/intra-arterial-contrasted-cone-beam-computed-tomography-assessment-of-vessels-distal-from-occluded-site-in-acute-ischemic-stroke-with-major-vessel-occlusion
#17
Tatsuo Amano, Masayuki Sato, Yuji Matsumaru, Hideyuki Sakuma, Syogo Yoda, Yusuke Hamada
Characterization of vessels distal from occluded site is important when considering endovascular revascularization therapy (EVT) for acute ischemic stroke. The goal of this study was to assess the clinical value of intra-arterial contrasted high-resolution cone-beam computed tomography from the ascending aorta (Ao-CBCT) for visualization of the vessels distal from occluded site. Acute ischemic stroke patients with large vessel occlusion who were to undergo EVT were evaluated. In EVT, digital subtraction angiography (DSA) and Ao-CBCT were performed with local anesthesia...
April 26, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28447493/m2-segment-dissection-of-middle-cerebral-artery-diagnosed-using-high-resolution-magnetic-resonance-imaging
#18
Xiaoyan Song, Haiyan Lv, Jianjun Tang, Qing Zhang, Qiaoshu Wang
Middle cerebral artery (MCA) dissection is a rare cause of ischemic stroke, especially in the M2 or M3 segments. Diagnosis of intracranial artery dissection remains challenging. We herein report a case of M2 segment dissection of the MCA with typical features of an intimal flap and intramural hematoma diagnosed using high-resolution 3T magnetic resonance imaging. This imaging technique might be a more effective noninvasive method by which to diagnose M2 segment dissection of the MCA than either computed tomography angiography or digital subtraction angiography...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28445296/a-case-of-cerebral-hyperperfusion-following-spontaneous-recanalization-of-occluded-middle-cerebral-artery-reperfusion-injury-or-true-cerebral-hyperperfusion-syndrome
#19
Ziqi Xu, Jiajia Zhou, Hui Liang, Benyan Luo, Ping Liu
BACKGROUND: Cerebral hyperperfusion syndrome (CHS) and reperfusion injury are distinct pathological phenomena. CASE SUMMARY: We present the case of a young ischemic stroke patient with middle cerebral artery (MCA) occlusion and spontaneous recanalization. Follow-up transcranial Doppler ultrasound showed high velocity flow in the left MCA, and neuroimaging revealed infarction, brain edema, artery dilatation, and hyperperfusion, consistent with both CHS and reperfusion injury...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445139/pannexin1-knockout-and-blockade-reduces-ischemic-stroke-injury-in-female-but-not-in-male-mice
#20
Moises Freitas-Andrade, John F Bechberger, Brian A MacVicar, Victor Viau, Christian C Naus
The membrane channel Pannexin 1 (Panx1) mediates apoptotic and inflammatory signaling cascades in injured neurons, responses previously shown to be sexually dimorphic under ischemic conditions. We tested the hypothesis that Panx1 plays an underlying role in mediating sex differences in stroke outcome responses. Middle-aged, 8-9 month old male and female wild type and Panx1 KO mice were subjected to permanent middle cerebral artery (MCA) occlusion, and infarct size and astrocyte and microglia activation were assessed 4 days later...
June 6, 2017: Oncotarget
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