Kenzaburo Nakajima, Takeshi Aiba, Takeru Makiyama, Suguru Nishiuchi, Seiko Ohno, Koichi Kato, Yuta Yamamoto, Takahiro Doi, Satoshi Shizuta, Kenji Onoue, Nobue Yagihara, Taisuke Ishikawa, Ichiro Watanabe, Hiroshi Kawakami, Yasushi Oginosawa, Nobuyuki Murakoshi, Akihiko Nogami, Kazutaka Aonuma, Yoshihiko Saito, Takeshi Kimura, Satoshi Yasuda, Naomasa Makita, Wataru Shimizu, Minoru Horie, Kengo Kusano
BACKGROUND: Mutation in the lamin A/C gene (LMNA) is associated with several cardiac phenotypes, such as cardiac conduction disorders (CCD), atrial arrhythmia (AA), malignant ventricular arrhythmia (MVA) and left ventricular dysfunction (LVD), leading to sudden cardiac death (SCD) and/or end-stage heart failure. We investigated how these phenotypes are associated with each other and which of them are most important for total mortality. Methods and Results: A multicenter registry included 110 LMNA mutation carriers (age, 43±15 years, male: 62%) from 60 families...
October 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society