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Breast cancer and microcalcification

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https://www.readbyqxmd.com/read/29150365/correlation-between-ultrasound-appearance-of-small-breast-cancer-and-axillary-lymph-node-metastasis
#1
Xiaoqin Yu, Xiaoyan Hao, Jing Wan, Yingying Wang, Lan Yu, Binyue Liu
To study the correlation of ultrasonographic signs of small breast cancer (maximum diameter ≤2.0 cm) with axillary lymph node metastasis, pre-operative ultrasonographic images of 153 small breast malignant neoplasms in 143 breast cancer patients were analyzed according to their pathologic features. Of the small breast tumors included, 47 showed axillary lymph node metastasis. Diagnosis of all patients was obtained with radical axillary surgery or a sentinel lymph node biopsy procedure. Ultrasonographic signs included irregular shape, microlobulated contour, spiculation, microcalcification, posterior echo attenuation, blood-flow grade, perforating vessels, changes in fascia or cooper's ligament and maximum cortical thickness of lymph nodes...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29122667/is-breast-mri-a-helpful-additional-diagnostic-test-in-suspicious-mammographic-microcalcifications
#2
Pascal A T Baltzer, Barbara Bennani-Baiti, Alexander Stöttinger, Alexander Bumberger, Panagiotis Kapetas, Paola Clauser
PURPOSE: Microcalcifications are a common finding in mammography and usually require invasive procedures to diagnose or exclude malignancy. As many microcalcifications are due to benign lesions, we wanted to assess whether breast MRI as an additional diagnostic tool may be used to distinguish benign from malignant in this setting. MATERIALS AND METHODS: Eligible for this retrospective, IRB-approved observational study were 858 consecutive patients (mean age 54±11years) undergoing stereotactically-guided biopsies of suspicious mammographic microcalcifications during three year at our institution...
November 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29110671/residual-microcalcifications-after-neoadjuvant-chemotherapy-for-locally-advanced-breast-cancer-comparison-of-the-accuracies-of-mammography-and-mri-in-predicting-pathological-residual-tumor
#3
Yeong Yi An, Sung Hun Kim, Bong Joo Kang
BACKGROUND: The aims of this study were to correlate residual mammographic microcalcifications after neoadjuvant chemotherapy (NAC) with pathological results and to compare the accuracy of mammography (MG) and magnetic resonance imaging (MRI) in predicting the size of residual tumors. METHODS: The imaging findings and pathological results for 29 patients with residual microcalcifications after NAC were reviewed. We compared the agreement of the measured extent of residual microcalcifications based on MG and residual enhancement based on MRI with the residual tumor size based on pathology...
November 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29072858/flat-epithelial-atypia-conservative-management-of-patients-without-residual-microcalcifications-post-vacuum-assisted-breast-biopsy
#4
Simone Schiaffino, Licia Gristina, Alessandro Villa, Simona Tosto, Francesco Monetti, Franca Carli, Massimo Calabrese
OBJECTIVE: To determine the malignancy rate (defined in this study as stability or absence of malignancy developed on close imaging follow-up post-biopsy) of conservative management in patients with a vacuum-assisted breast biopsy (VAB) diagnosis of flat epithelial atypia (FEA), performed on single group of microcalcifications, completely removed during procedure. METHODS: This is a retrospective, monocentric, observational study, approved by IRB. Inclusion criteria were: VAB performed on a single group of microcalcifications; the absence of residual calcifications post-VAB; diagnosis of isolated FEA as the most advanced proliferative lesion; radiological follow-up at least of 12 months...
November 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29059966/ensemble-of-convolutional-neural-networks-for-classification-of-breast-microcalcification-from-mammograms
#5
Egemen Sert, Seyda Ertekin, Ugur Halici
Human level recall performance in detecting breast cancer considering microcalcifications from mammograms has a recall value between 74.5% and 92.3%. In this research, we approach to breast microcalcification classification problem using convolutional neural networks along with various preprocessing methods such as contrast scaling, dilation, cropping etc. and decision fusion using ensemble of networks. Various experiments on Digital Database for Screening Mammography dataset showed that preprocessing poses great importance on the classification performance...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28941754/breast-screening-what-can-the-interval-cancer-review-teach-us-are-we-perhaps-being-a-bit-too-hard-on-ourselves
#6
Katerina Lekanidi, Phil Dilks, Tamara Suaris, Steffan Kennett, Hema Purushothaman
PURPOSE: The aim of this study was to determine the features that make interval cancers apparent on the preceding screening mammogram and determine whether changes in the ways of performing the interval cancer review will affect the true interval cancer rate. MATERIALS AND METHODS: This study was approved by the clinical governance committee. Mammograms of women diagnosed with an interval cancer were included in the study if they had been allocated to either the "suspicious signs" group or "subtle signs" group, during the historic interval cancer review...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28739748/application-of-localization-and-needle-placement-guided-by-mammographic-ultrasound-and-fiberoptic-ductoscopy-for-resection-of-non-palpable-breast-lesions
#7
Zhu Yuan, Xiang Qu, Zhong-Tao Zhang, Wen G Jiang
AIM: To evaluate the usefulness of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions. PATIENTS AND METHODS: Eighty-three patients undergoing needle localization and biopsy of non-palpable breast lesions under mammographic, ultrasound or fiberoptic ductoscopy guidance from June 2013 to December 2014 in Beijing Friendship Hospital were included in the study. The preoperative imaging assessment, application of localization needles, surgical operation and pathological examination were recorded and analyzed retrospectively...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28713499/relationship-among-mammographic-findings-with-histopathologic-type-of-breast-cancer-and-human-epidermal-growth-factor-receptor-2-her2-in-young-women
#8
Donya Farrokh, Samineh Boloursaz, Fatemeh Homai
INTRODUCTION: Radiological measures to diagnose breast cancer, including mammographic and ultrasound assessments in young women, are associated with restrictions affecting the use of this tool. No adequate information is available on mammography view in young people with breast cancer and its relationship with pathologic type and epidermal growth factor receptor 2 (HER2) as a prognostic marker, especially in the Iranian race. This study was conducted to examine the relationship between mammographic findings of young women with breast cancer with diagnosed histopathologic type and HER2 marker status...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28673535/nipple-sparing-and-skin-sparing-mastectomy-review-of-aims-oncological-safety-and-contraindications
#9
Viviana Galimberti, Elisa Vicini, Giovanni Corso, Consuelo Morigi, Sabrina Fontana, Virgilio Sacchini, Paolo Veronesi
Skin-sparing (SSM) and nipple-sparing (NSM) mastectomies are relatively new conservative surgical approaches to breast cancer. In SSM most of the breast skin is conserved to create a pocket that facilitates immediate breast reconstruction with implant or autologous graft to achieve a quality cosmetic outcome. NSM is closely similar except that the nipple-areola complex (NAC) is also conserved. Meta-analyses indicate that outcomes for SSM and NSM do not differ from those for non-conservative mastectomies. Recurrence rates in the NAC after NSM are acceptably low (0-3...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28668423/the-breast-lesion-excision-system-bles-under-stereotactic-guidance-cannot-be-used-as-a-therapeutic-tool-in-the-excision-of-small-areas-of-microcalcifications-in-the-breast
#10
Ruxandra-Iulia Milos, Maria Bernathova, Pascal A Baltzer, Katja Pinker-Domenig, Panagiotis Kapetas, Margaretha Rudas, Thomas H Helbich
OBJECTIVE: The breast lesion excision system (BLES) is a new, automatic percutaneous breast biopsy device that excises single large specimens using radiofrequency cutting. The aim of this study was to determine whether BLES, under stereotactic guidance, can be used as a therapeutic tool in the assessment of small areas of microcalcifications in the breast by providing samples with clear margins. MATERIAL AND METHODS: In this retrospective study, 149 patients with suspicious (BIRADS 4 or 5) small areas of microcalcifications underwent stereotactic-guided BLES...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28652562/correlation-factors-analysis-of-breast-cancer-tumor-volume-doubling-time-measured-by-3d-ultrasound
#11
Shuyin Zhang, Yan Ding, Qiaoying Zhou, Cheng Wang, Pengxi Wu, Ji Dong
BACKGROUND Tumor volume doubling time (TVDT) is relatively important for breast cancer diagnosis and prognosis evaluation. This study aimed to analyze the related factors that may affect the TVDT of breast cancer by three-dimensional ultrasound (3D-US). MATERIAL AND METHODS A total of 69 breast cancer patients were selected. 3D-US was applied to measure the volume of breast lumps diagnosed as BI-RADS-US 4A by conventional ultrasound. TVDT was calculated according to the formula TVDT=DT×log2/log(V2/V1). Multiple linear regression analysis was performed to analyze the factors influencing breast cancer TVDT...
June 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28618103/secretory-pathway-ca-2-atpases-promote-in-vitro-microcalcifications-in-breast-cancer-cells
#12
Donna Dang, Hari Prasad, Rajini Rao
Calcification of the breast is often an outward manifestation of underlying molecular changes that drive carcinogenesis. Up to 50% of all non-palpable breast tumors and 90% of ductal carcinoma in situ present with radiographically dense mineralization in mammographic scans. However, surprisingly little is known about the molecular pathways that lead to microcalcifications in the breast. Here, we report on a rapid and quantitative in vitro assay to monitor microcalcifications in breast cancer cell lines, including MCF7, MDA-MB-231, and Hs578T...
November 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28582921/grouped-fuzzy-svm-with-em-based-partition-of-sample-space-for-clustered-microcalcification-detection
#13
Huiya Wang, Jun Feng, Hongyu Wang
BACKGROUND: Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. OBJECTIVE: To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. METHODS: In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection...
July 20, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28570750/epithelial-mesenchymal-transition-inducer-snail1-and-invasive-potential-of-intraductal-breast-cancer
#14
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
BACKGROUND AND OBJECTIVES: Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the final invasion. METHODS: A total of 209 patients with histologically diagnosed pure DCIS entered the study. Snail1 reactivity was evaluated with immunohistochemistry in tumor tissue from stereotactic vacuum-assisted biopsy of suspicious microcalcifications...
November 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28534354/the-value-of-stereotactic-vacuum-assisted-breast-biopsy-in-the-investigation-of-microcalcifications-a-six-year-experience-with-853-patients
#15
Panagiotis M Safioleas, Dimitra Koulocheri, Nikolaos Michalopoulos, Paraskevi Liacou, Ioannis Flessas, Afroditi Nonni, Konstantinos Kontzoglou, George C Zografos
PURPOSE: Vacuum Assisted Breast Biopsy (VABB) is a minimal invasive technique, in the diagnostic approach for non palpable lesions. The aim of this study was to evaluate the efficacy and accuracy of VABB in the investigation of breast microcalcifications, a significant mammographic sign of early breast cancer. The rate of histological underestimation and the false negative rate were assessed based on the follow up data and the histological examination of the surgical specimens. METHODS: From January 2005 to November 2011, 853 women with mammographically detected microcalcifications, classified as BI-RADS 3-5, were referred to our Breast Unit for evaluation...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28526187/chemotherapy-may-eradicate-ductal-carcinoma-in-situ-dcis-but-not-the-associated-microcalcifications
#16
MULTICENTER STUDY
H Goldberg, J Zandbank, V Kent, M Leonov-Polak, A Livoff, A Chernihovsky, M Guindy, E Evron
INTRODUCTION: We studied the effect of neoadjuvant chemotherapy (NAC) ± trastuzumab on the ductal carcinoma in situ (DCIS) component in patients with locally advanced breast cancer who achieved pathological complete response (pCR). METHODS: The diagnostic biopsies of 92 consecutive breast cancer patients that were treated with neoadjuvant chemotherapy (NAC) ± trastuzumab were evaluated for the presence of DCIS. Upon completion of NAC, the surgical specimens were evaluated for complete eradication of both the invasive and non-invasive cancer in the breast...
August 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28512732/decision-making-in-the-surgical-management-of-invasive-breast-cancer-part-1-lumpectomy-mastectomy-and-contralateral-prophylactic-mastectomy
#17
REVIEW
Lisa A Newman
Several prospective randomized clinical trials conducted internationally have proven the safety and survival equivalence of breast-conserving surgery compared with mastectomy. Adjuvant radiation is routinely recommended following lumpectomy surgery to minimize the risk of local recurrence. Comprehensive breast imaging (including bilateral mammography with diagnostic views and ultrasound evaluation), in addition to clinical examination, is essential to rule out potential contralateral pathology and to optimally characterize the extent of disease...
May 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28450564/diagnostic-pet-imaging-of-mammary-microcalcifications-using-64-cu-dota-alendronate-in-a-rat-model-of-breast-cancer
#18
Bradley J Ahrens, Lin Li, Alexandra K Ciminera, Junie Chea, Erasmus Poku, James R Bading, Michael R Weist, Marcia M Miller, David M Colcher, John E Shively
The development of improved breast cancer screening methods is hindered by a lack of cancer-specific imaging agents and effective small-animal models to test them. The purpose of this study was to evaluate (64)Cu-DOTA-alendronate as a mammary microcalcification-targeting PET imaging agent, using an ideal rat model. Our long-term goal is to develop (64)Cu-DOTA-alendronate for the detection and noninvasive differentiation of malignant versus benign breast tumors with PET. Methods: DOTA-alendronate was synthesized, radiolabeled with (64)Cu, and administered to normal or tumor-bearing aged, female, retired breeder Sprague-Dawley rats for PET imaging...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28436856/task-based-modeling-of-a-5k-ultra-high-resolution-medical-imaging-system-for-digital-breast-tomosynthesis
#19
Chumin Zhao, Jerzy Kanicki
High-resolution, low-noise X-ray detectors based on CMOS active pixel sensor (APS) technology have demonstrated superior imaging performance for digital breast tomosynthesis (DBT). This paper presents a task-based model for a high-resolution medical imaging system to evaluate its ability to detect simulated microcalcifications and masses as lesions for breast cancer. A 3-D cascaded system analysis for a 50- [Formula: see text] pixel pitch CMOS APS X-ray detector was integrated with an object task function, a medical imaging display model, and the human eye contrast sensitivity function to calculate the detectability index and area under the ROC curve (AUC)...
September 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28420325/usefulness-of-grayscale-inverted-images-in-addition-to-standard-images-in-digital-mammography
#20
Ayşegül Altunkeser, M Kazım Körez
BACKGROUND: Mammography is essential for early diagnosis of breast cancer, which is the most common type of cancer in females that is associated with a high mortality rate. We investigated whether evaluation of the grayscale inverted images of mammograms would aid in increasing the diagnostic sensitivity of the mammographic imaging technique. METHODS: Our study included 636 mammograms of 159 women who had undergone digital mammography. Standard, grayscale inverted, and standard plus grayscale inverted images were sequentially examined three times, at 15-day intervals, for the presence or assessment of pathological changes in the skin, calcification, asymmetric density, mass lesions, structural distortions, and intramammary and axillary lymph nodes...
April 18, 2017: BMC Medical Imaging
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