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Breast cancer and microcalcification

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https://www.readbyqxmd.com/read/29247886/microcalcification-morphological-descriptors-and-parenchyma-fractal-dimension-hierarchically-interact-in-breast-cancer-a-diagnostic-perspective
#1
Garima Verma, Maria Laura Luciani, Alessandro Palombo, Linda Metaxa, Giovanna Panzironi, Federica Pediconi, Alessandro Giuliani, Mariano Bizzarri, Virginia Todde
INTRODUCTION: Herein, we propose a Systems Biology approach aimed at identifying quantitative morphological parameters useful in discriminating benign from malignant breast microcalcifications at digital mammography. MATERIALS AND METHODS: The study includes 31 patients in which microcalcifications had been detected during XR mammography and were further confirmed by stereotactic (XR-guided) biopsies. Patients were classified according to the BIRADS (Breast Imaging-Reporting and Data System), along with their parenchyma fractal dimension and biopsy size...
December 11, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29242735/microcalcified-hepatic-metastases-incidentally-detected-on-f-18-naf-pet-ct-in-a-patient-with-prostate-cancer
#2
Gul Ege Aktas, Ali Sarıkaya, Nuray Can, Selin Soyluoglu Demir
F-18 NaF PET/CT evaluation has gained importance in recent years. Achievements from F-18 NaF PET/CT are: higher sensitivity of positron imaging, higher target background ratio with higher tracer accumulation in bone hydroxyapatite and higher specificity through CT correlation. These properties have also given directions to new research fields based on imaging microcalcifications, very recently. A limited number of cases have reported the F-18 NaF uptake in macrocalcified soft tissue metastases. Although the presence of microcalcification was not proved; accumulation of F-18 NaF in the metastatic brain lesion with no visible calcification on the CT, in a patient with ductal breast carcinoma has also been reported...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29224890/advances-in-breast-intervention-where-are-we-now-and-where-should-we-be
#3
REVIEW
W B G Sanderink, R M Mann
In the past four decades, a variety of methods for minimal or non-invasive diagnosis and treatment of breast cancer have been introduced. Although breast imaging has become more and more specific for diagnosis, specimen biopsy with histopathological confirmation is still necessary. Core-needle biopsy under ultrasound guidance is the appropriate first choice for the diagnosis of most lesions. Fine-needle aspiration is of interest for identification of the presence of metastatic disease in abnormal lymph nodes...
December 7, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29221896/correlative-imaging-reveals-physiochemical-heterogeneity-of-microcalcifications-in-human-breast-carcinomas
#4
Jennie A M R Kunitake, Siyoung Choi, Kayla X Nguyen, Meredith M Lee, Frank He, Daniel Sudilovsky, Patrick G Morris, Maxine S Jochelson, Clifford A Hudis, David A Muller, Peter Fratzl, Claudia Fischbach, Admir Masic, Lara A Estroff
Microcalcifications (MCs) are routinely used to detect breast cancer in mammography. Little is known, however, about their materials properties and associated organic matrix, or their correlation to breast cancer prognosis. We combine histopathology, Raman microscopy, and electron microscopy to image MCs within snap-frozen human breast tissue and generate micron-scale resolution correlative maps of crystalline phase, trace metals, particle morphology, and organic matrix chemical signatures within high grade ductal carcinoma in situ (DCIS) and invasive cancer...
December 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29210533/rapid-differential-diagnosis-of-breast-microcalcification-using-targeted-near-infrared-fluorophores
#5
Min Ho Park, Wonbong Lim, Danbi Jo, Jin Seok Jung, Subin Kim, Jangho Kim, Hyo Soon Lim, Ji Shin Lee, Jung-Joon Min, Hoon Hyun
Early detection and differential diagnosis of breast microcalcifications are of significant importance in effective treatment of early breast cancer, because mineral composition of breast calcification is directly associated with different pathological states. However, applying image-based modalities for component identification in breast calcification remains challenging, because no calcification-specific contrast agent is available to distinguish between benign and malignant (type I and type II, respectively) calcifications of breast lesions...
December 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29190656/mri-for-the-assessment-of-malignancy-in-bi-rads-4-mammographic-microcalcifications
#6
Barbara Bennani-Baiti, Matthias Dietzel, Pascal A Baltzer
PURPOSE: Assess the performance of breast MRI to diagnose breast cancer in BI-RADS 4 microcalcifications detected by mammography. MATERIALS AND METHODS: This retrospective, IRB-approved study included 248 consecutive contrast-enhanced breast MRI (1.5T, protocol in accordance with EUSOBI recommendations) performed to further diagnose BI-RADS 4 microcalcifications detected at mammography during a 3-year period. Standard of reference had to be established by histopathology...
2017: PloS One
https://www.readbyqxmd.com/read/29150365/correlation-between-ultrasound-appearance-of-small-breast-cancer-and-axillary-lymph-node-metastasis
#7
Xiaoqin Yu, Xiaoyan Hao, Jing Wan, Yingying Wang, Lan Yu, Binyue Liu
To study the correlation of ultrasonographic signs of small breast cancer (maximum diameter ≤2.0 cm) with axillary lymph node metastasis, pre-operative ultrasonographic images of 153 small breast malignant neoplasms in 143 breast cancer patients were analyzed according to their pathologic features. Of the small breast tumors included, 47 showed axillary lymph node metastasis. Diagnosis of all patients was obtained with radical axillary surgery or a sentinel lymph node biopsy procedure. Ultrasonographic signs included irregular shape, microlobulated contour, spiculation, microcalcification, posterior echo attenuation, blood-flow grade, perforating vessels, changes in fascia or cooper's ligament and maximum cortical thickness of lymph nodes...
February 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29122667/is-breast-mri-a-helpful-additional-diagnostic-test-in-suspicious-mammographic-microcalcifications
#8
Pascal A T Baltzer, Barbara Bennani-Baiti, Alexander Stöttinger, Alexander Bumberger, Panagiotis Kapetas, Paola Clauser
PURPOSE: Microcalcifications are a common finding in mammography and usually require invasive procedures to diagnose or exclude malignancy. As many microcalcifications are due to benign lesions, we wanted to assess whether breast MRI as an additional diagnostic tool may be used to distinguish benign from malignant in this setting. MATERIALS AND METHODS: Eligible for this retrospective, IRB-approved observational study were 858 consecutive patients (mean age 54±11years) undergoing stereotactically-guided biopsies of suspicious mammographic microcalcifications during three year at our institution...
February 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29110671/residual-microcalcifications-after-neoadjuvant-chemotherapy-for-locally-advanced-breast-cancer-comparison-of-the-accuracies-of-mammography-and-mri-in-predicting-pathological-residual-tumor
#9
Yeong Yi An, Sung Hun Kim, Bong Joo Kang
BACKGROUND: The aims of this study were to correlate residual mammographic microcalcifications after neoadjuvant chemotherapy (NAC) with pathological results and to compare the accuracy of mammography (MG) and magnetic resonance imaging (MRI) in predicting the size of residual tumors. METHODS: The imaging findings and pathological results for 29 patients with residual microcalcifications after NAC were reviewed. We compared the agreement of the measured extent of residual microcalcifications based on MG and residual enhancement based on MRI with the residual tumor size based on pathology...
November 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29072858/flat-epithelial-atypia-conservative-management-of-patients-without-residual-microcalcifications-post-vacuum-assisted-breast-biopsy
#10
Simone Schiaffino, Licia Gristina, Alessandro Villa, Simona Tosto, Francesco Monetti, Franca Carli, Massimo Calabrese
OBJECTIVE: To determine the malignancy rate (defined in this study as stability or absence of malignancy developed on close imaging follow-up post-biopsy) of conservative management in patients with a vacuum-assisted breast biopsy (VAB) diagnosis of flat epithelial atypia (FEA), performed on single group of microcalcifications, completely removed during procedure. METHODS: This is a retrospective, monocentric, observational study, approved by IRB. Inclusion criteria were: VAB performed on a single group of microcalcifications; the absence of residual calcifications post-VAB; diagnosis of isolated FEA as the most advanced proliferative lesion; radiological follow-up at least of 12 months...
November 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29059966/ensemble-of-convolutional-neural-networks-for-classification-of-breast-microcalcification-from-mammograms
#11
Egemen Sert, Seyda Ertekin, Ugur Halici
Human level recall performance in detecting breast cancer considering microcalcifications from mammograms has a recall value between 74.5% and 92.3%. In this research, we approach to breast microcalcification classification problem using convolutional neural networks along with various preprocessing methods such as contrast scaling, dilation, cropping etc. and decision fusion using ensemble of networks. Various experiments on Digital Database for Screening Mammography dataset showed that preprocessing poses great importance on the classification performance...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28941754/breast-screening-what-can-the-interval-cancer-review-teach-us-are-we-perhaps-being-a-bit-too-hard-on-ourselves
#12
Katerina Lekanidi, Phil Dilks, Tamara Suaris, Steffan Kennett, Hema Purushothaman
PURPOSE: The aim of this study was to determine the features that make interval cancers apparent on the preceding screening mammogram and determine whether changes in the ways of performing the interval cancer review will affect the true interval cancer rate. MATERIALS AND METHODS: This study was approved by the clinical governance committee. Mammograms of women diagnosed with an interval cancer were included in the study if they had been allocated to either the "suspicious signs" group or "subtle signs" group, during the historic interval cancer review...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28739748/application-of-localization-and-needle-placement-guided-by-mammographic-ultrasound-and-fiberoptic-ductoscopy-for-resection-of-non-palpable-breast-lesions
#13
Zhu Yuan, Xiang Qu, Zhong-Tao Zhang, Wen G Jiang
AIM: To evaluate the usefulness of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions. PATIENTS AND METHODS: Eighty-three patients undergoing needle localization and biopsy of non-palpable breast lesions under mammographic, ultrasound or fiberoptic ductoscopy guidance from June 2013 to December 2014 in Beijing Friendship Hospital were included in the study. The preoperative imaging assessment, application of localization needles, surgical operation and pathological examination were recorded and analyzed retrospectively...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28713499/relationship-among-mammographic-findings-with-histopathologic-type-of-breast-cancer-and-human-epidermal-growth-factor-receptor-2-her2-in-young-women
#14
Donya Farrokh, Samineh Boloursaz, Fatemeh Homai
INTRODUCTION: Radiological measures to diagnose breast cancer, including mammographic and ultrasound assessments in young women, are associated with restrictions affecting the use of this tool. No adequate information is available on mammography view in young people with breast cancer and its relationship with pathologic type and epidermal growth factor receptor 2 (HER2) as a prognostic marker, especially in the Iranian race. This study was conducted to examine the relationship between mammographic findings of young women with breast cancer with diagnosed histopathologic type and HER2 marker status...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28673535/nipple-sparing-and-skin-sparing-mastectomy-review-of-aims-oncological-safety-and-contraindications
#15
Viviana Galimberti, Elisa Vicini, Giovanni Corso, Consuelo Morigi, Sabrina Fontana, Virgilio Sacchini, Paolo Veronesi
Skin-sparing (SSM) and nipple-sparing (NSM) mastectomies are relatively new conservative surgical approaches to breast cancer. In SSM most of the breast skin is conserved to create a pocket that facilitates immediate breast reconstruction with implant or autologous graft to achieve a quality cosmetic outcome. NSM is closely similar except that the nipple-areola complex (NAC) is also conserved. Meta-analyses indicate that outcomes for SSM and NSM do not differ from those for non-conservative mastectomies. Recurrence rates in the NAC after NSM are acceptably low (0-3...
August 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28668423/the-breast-lesion-excision-system-bles-under-stereotactic-guidance-cannot-be-used-as-a-therapeutic-tool-in-the-excision-of-small-areas-of-microcalcifications-in-the-breast
#16
Ruxandra-Iulia Milos, Maria Bernathova, Pascal A Baltzer, Katja Pinker-Domenig, Panagiotis Kapetas, Margaretha Rudas, Thomas H Helbich
OBJECTIVE: The breast lesion excision system (BLES) is a new, automatic percutaneous breast biopsy device that excises single large specimens using radiofrequency cutting. The aim of this study was to determine whether BLES, under stereotactic guidance, can be used as a therapeutic tool in the assessment of small areas of microcalcifications in the breast by providing samples with clear margins. MATERIAL AND METHODS: In this retrospective study, 149 patients with suspicious (BIRADS 4 or 5) small areas of microcalcifications underwent stereotactic-guided BLES...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28652562/correlation-factors-analysis-of-breast-cancer-tumor-volume-doubling-time-measured-by-3d-ultrasound
#17
Shuyin Zhang, Yan Ding, Qiaoying Zhou, Cheng Wang, Pengxi Wu, Ji Dong
BACKGROUND Tumor volume doubling time (TVDT) is relatively important for breast cancer diagnosis and prognosis evaluation. This study aimed to analyze the related factors that may affect the TVDT of breast cancer by three-dimensional ultrasound (3D-US). MATERIAL AND METHODS A total of 69 breast cancer patients were selected. 3D-US was applied to measure the volume of breast lumps diagnosed as BI-RADS-US 4A by conventional ultrasound. TVDT was calculated according to the formula TVDT=DT×log2/log(V2/V1). Multiple linear regression analysis was performed to analyze the factors influencing breast cancer TVDT...
June 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28618103/secretory-pathway-ca-2-atpases-promote-in-vitro-microcalcifications-in-breast-cancer-cells
#18
Donna Dang, Hari Prasad, Rajini Rao
Calcification of the breast is often an outward manifestation of underlying molecular changes that drive carcinogenesis. Up to 50% of all non-palpable breast tumors and 90% of ductal carcinoma in situ present with radiographically dense mineralization in mammographic scans. However, surprisingly little is known about the molecular pathways that lead to microcalcifications in the breast. Here, we report on a rapid and quantitative in vitro assay to monitor microcalcifications in breast cancer cell lines, including MCF7, MDA-MB-231, and Hs578T...
November 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28582921/grouped-fuzzy-svm-with-em-based-partition-of-sample-space-for-clustered-microcalcification-detection
#19
Huiya Wang, Jun Feng, Hongyu Wang
BACKGROUND: Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. OBJECTIVE: To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. METHODS: In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection...
July 20, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28570750/epithelial-mesenchymal-transition-inducer-snail1-and-invasive-potential-of-intraductal-breast-cancer
#20
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
BACKGROUND AND OBJECTIVES: Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the final invasion. METHODS: A total of 209 patients with histologically diagnosed pure DCIS entered the study. Snail1 reactivity was evaluated with immunohistochemistry in tumor tissue from stereotactic vacuum-assisted biopsy of suspicious microcalcifications...
November 2017: Journal of Surgical Oncology
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