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Breast cancer and microcalcification

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https://www.readbyqxmd.com/read/27895868/immunohistochemical-subtypes-of-breast-cancer-correlation-with-clinicopathological-and-radiological-factors
#1
Yu-Mee Sohn, Kyunghwa Han, Mirinae Seo
BACKGROUND: The relationship between biomarkers and imaging features is important because imaging findings can predict molecular features. OBJECTIVES: To investigate the relationship between clinicopathologic and radiologic factors and the immunohistochemical (IHC) profiles associated with breast cancer. PATIENTS AND METHODS: From December 2004 to September 2013, 200 patients (mean age, 56 years; range, 29 - 82 years) were diagnosed with breast cancer and underwent surgery at our institution...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27847817/automatic-detection-of-pectoral-muscle-region-for-computer-aided-diagnosis-using-mias-mammograms
#2
Woong Bae Yoon, Ji Eun Oh, Eun Young Chae, Hak Hee Kim, Soo Yeul Lee, Kwang Gi Kim
The computer-aided detection (CAD) systems have been developed to help radiologists with the early detection of breast cancer. This system provides objective and accurate information to reduce the misdiagnosis of the disease. In mammography, the pectoral muscle region is used as an index to compare the symmetry between the left and right images in the mediolateral oblique (MLO) view. The pectoral muscle segmentation is necessary for the detection of microcalcification or mass because the pectoral muscle has a similar pixel intensity as that of lesions, which affects the results of automatic detection...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27832842/flat-epithelial-atypia-on-core-needle-biopsy-must-we-surgically-excise
#3
A A Acott, A T Mancino
: Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS...
October 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27803959/accelerated-partial-breast-irradiation-with-external-beam-radiotherapy-first-results-of-the-german-phase%C3%A2-2-trial
#4
Oliver J Ott, Vratislav Strnad, Wilhelm Stillkrieg, Wolfgang Uter, Matthias W Beckmann, Rainer Fietkau
BACKGROUND AND PURPOSE: To evaluate the feasibility and efficacy of external beam three-dimensional (3D) conformal accelerated partial breast irradiation (APBI) for selected patients with early breast cancer. PATIENTS AND METHODS: Between 2011 and 2016, 72 patients were recruited for this prospective phase 2 trial. Patients were eligible for APBI if they had histologically confirmed breast cancer or pure ductal carcinoma in situ (DCIS), a tumor diameter ≤3 cm, clear resection margins ≥2 mm, no axillary lymph node involvement, no distant metastases, tumor bed clips, and were aged ≥50 years...
November 1, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27768681/degree-of-enhancement-on-contrast-enhanced-spectral-mammography-cesm-and-lesion-type-on-mammography-mg-comparison-based-on-histological-results
#5
Elżbieta Łuczyńska, Joanna Niemiec, Edward Hendrick, Sylwia Heinze, Janusz Jaszczyński, Jerzy Jakubowicz, Beata Sas-Korczyńska, Janusz Rys
BACKGROUND Contrast enhanced spectral mammography (CESM) is a new method of breast cancer diagnosis in which an iodinated contrast agent is injected and dual-energy mammography is obtained in multiple views of the breasts. The aim of this study was to compare the degree of enhancement on CESM with lesion characteristics on mammography (MG) and lesion histology in women with suspicious breast lesions. MATERIAL AND METHODS The degree of enhancement on CESM (absent, weak, medium, or strong) was compared to lesion characteristics on MG (mass, mass with microcalcifications, or microcalcifications alone) and histology (infiltrating carcinoma, intraductal carcinoma, or benign) to compare sensitivity of the two modalities and to establish correlations that might improve diagnostic accuracy...
October 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27740905/technical-considerations-for-red-marking-ink-use-when-interpreting-specimen-radiographs-case-report
#6
Matthew E Brice, Marisa Gossweiler, Larry Bennett
Artifacts are universal across all imaging modalities, varying in their conspicuity and significance. In this report three patients with pathology-proven breast cancer who had densities masquerading as microcalcifications at the resection margins of the lumpectomy specimens, but had negative microscopic margins, will be discussed. It was determined that these pseudocalcifications were the result of ink precipitates from a commonly utilized tissue marking dye. This artifact was further evaluated and reproduced by utilizing a boneless chicken breast as a phantom...
October 13, 2016: Radiology
https://www.readbyqxmd.com/read/27667335/time-to-go-wireless-a-15-year-single-institution-experience-of-radioisotope-occult-lesion-localisation-roll-for-impalpable-breast-lesions
#7
S C Hawkins, I Brown, P King, M El-Gammal, K Stepp, S Widdison, M Barta, N Jackson, P Drew
INTRODUCTION: Wire guided localisation (WGL) is the standard localisation technique for impalpable breast lesions. Radio-guided occult lesion localisation (ROLL) has been proposed as an alternative. We have been performing ROLL for therapeutic wide local excisions (WLE) and diagnostic excision biopsies (DEB) for the last 15 years. We present the largest reported consecutive series of ROLL excisions to date. PATIENTS AND METHODS: One thousand thirty nine consecutive patients who underwent ROLL for impalpable breast lesions were identified from a prospectively collected database...
September 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27648060/clinical-value-of-mammography-in-diagnosis-and-identification-of-breast-mass
#8
Hongjun Li, Shanhua Zhang, Qingyuan Wang, Rongguang Zhu
OBJECTIVE: To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS: A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagnosis and Pathology diagnosis in breast lump, and the detection of microcalcifications, phyllode, and observe the image performance of mammography...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27644557/thirty-percent-of-ductal-carcinoma-in-situ-of-the-breast-in-japan-is-extremely-low-grade-er-her2-type-without-comedo-necrosis
#9
Miyuki Kanematsu, Masami Morimoto, Masako Takahashi, Junko Honda, Yoshimi Bando, Takuya Moriya, Yukiko Tadokoro, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida, Hiroaki Toba, Mitsuteru Yoshida, Aiichiro Kajikawa, Akira Tangoku, Issei Imoto, Mitsunori Sasa
Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis...
2016: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/27617048/evaluation-of-doses-and-image-quality-in-mammography-with-screen-film-cr-and-dr-detectors-application-of-the-acr-phantom
#10
Wioletta Ślusarczyk-Kacprzyk, Witold Skrzyński, Ewa Fabiszewska
BACKGROUND: Different methods of image quality evaluation are routinely used for analogue and digital mammography systems in Poland. In the present study, image quality for several screen-film (SF), computed radiography (CR), and fully digital (DR) mammography systems was compared directly with the use of the ACR mammography accreditation phantom. MATERIAL/METHODS: Image quality and mean glandular doses were measured and compared for 47 mammography systems in the Mazovia Voivodeship in Poland, including 26 SF systems, 12 CR systems, and 9 DR systems...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27611215/dual-energy-contrast-enhanced-spectral-mammography-enhancement-analysis-on-bi-rads-4-non-mass-microcalcifications-in-screened-women
#11
Yun-Chung Cheung, Yu-Hsiang Juan, Yu-Ching Lin, Yung-Feng Lo, Hsiu-Pei Tsai, Shir-Hwa Ueng, Shin-Cheh Chen
BACKGROUND: Mammography screening is a cost-efficient modality with high sensitivity for detecting impalpable cancer with microcalcifications, and results in reduced mortality rates. However, the probability of finding microcalcifications without associated cancerous masses varies. We retrospectively evaluated the diagnosis and cancer probability of the non-mass screened microcalcifications by dual-energy contrast-enhanced spectral mammography (DE-CESM). PATIENTS AND METHODS: With ethical approval from our hospital, we enrolled the cases of DE-CESM for analysis under the following inclusion criteria: (1) referrals due to screened BI-RADS 4 microcalcifications; (2) having DE-CESM prior to stereotactic biopsy; (3) no associated mass found by sonography and physical examination; and (4) pathology-based diagnosis using stereotactic vacuum-assisted breast biopsy...
2016: PloS One
https://www.readbyqxmd.com/read/27585658/can-positron-emission-mammography-help-to-identify-clinically-significant-breast-cancer-in-women-with-suspicious-calcifications-on-mammography
#12
Almir G V Bitencourt, Eduardo N P Lima, Bruna R C Macedo, Jorge L F A Conrado, Elvira F Marques, Rubens Chojniak
OBJECTIVE: To evaluate the diagnostic accuracy of positron emission mammography (PEM) for identifying malignant lesions in patients with suspicious microcalcifications detected on mammography. METHODS: A prospective, single-centre study that evaluated 40 patients with suspicious calcifications at mammography and indication for percutaneous or surgical biopsy, with mean age of 56.4 years (range: 28-81 years). Patients who agreed to participate in the study underwent PEM with 18F-fluorodeoxyglucose before the final histological evaluation...
September 2, 2016: European Radiology
https://www.readbyqxmd.com/read/27498205/applying-data-mining-techniques-to-improve-breast-cancer-diagnosis
#13
Joana Diz, Goreti Marreiros, Alberto Freitas
In the field of breast cancer research, and more than ever, new computer aided diagnosis based systems have been developed aiming to reduce diagnostic tests false-positives. Within this work, we present a data mining based approach which might support oncologists in the process of breast cancer classification and diagnosis. The present study aims to compare two breast cancer datasets and find the best methods in predicting benign/malignant lesions, breast density classification, and even for finding identification (mass / microcalcification distinction)...
September 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27439354/ductal-carcinoma-in-situ-on-stereotactic-biopsy-of-suspicious-breast-microcalcifications-expression-of-sparc-secreted-protein-acidic-and-rich-in-cysteine-can-predict-postoperative-invasion
#14
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
BACKGROUND AND OBJECTIVES: Secreted protein, acidic and rich in cysteine (SPARC) is able to play an important role in cancer invasion due to de-adhesive properties and impact on stromal remodeling. The aim of study was to investigate SPARC expression in preoperatively diagnosed breast DCIS and to assess its predictive value for the final invasion. METHODS: A total of 209 patients with DCIS found on stereotactic vacuum-assisted biopsy of suspicious microcalcifications were studied prospectively...
October 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27406629/mammography-and-mri-for-screening-women-who-underwent-chest-radiation-therapy-lymphoma-survivors-recommendations-for-surveillance-from-the-italian-college-of-breast-radiologists-by-sirm
#15
Giovanna Mariscotti, Paolo Belli, Daniela Bernardi, Beniamino Brancato, Massimo Calabrese, Luca A Carbonaro, Beatrice Cavallo-Marincola, Francesca Caumo, Paola Clauser, Laura Martinchich, Stefania Montemezzi, Pietro Panizza, Federica Pediconi, Alberto Tagliafico, Rubina M Trimboli, Chiara Zuiani, Francesco Sardanelli
Women who underwent chest radiation therapy (CRT) during pediatric/young-adult age (typically, lymphoma survivors) have an increased breast cancer risk, in particular for high doses. The cumulative incidence from 40 to 45 years of age is 13-20 %, similar to that of BRCA mutation carriers for whom contrast-enhanced magnetic resonance imaging (MRI) is recommended. However, in women who underwent CRT, MRI sensitivity is lower (63-80 %) and that of mammography higher (67-70 %) than those observed in women with hereditary predisposition, due to a higher incidence of ductal carcinoma in situ with microcalcifications and low neoangiogenesis...
July 12, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27380025/computational-growth-model-of-breast-microcalcification-clusters-in-simulated-mammographic-environments
#16
Shayne M Plourde, Zach Marin, Zachary R Smith, Brian C Toner, Kendra A Batchelder, Andre Khalil
BACKGROUND: When screening for breast cancer, the radiological interpretation of mammograms is a difficult task, particularly when classifying precancerous growth such as microcalcifications (MCs). Biophysical modeling of benign vs. malignant growth of MCs in simulated mammographic backgrounds may improve characterization of these structures METHODS: A mathematical model based on crystal growth rules for calcium oxide (benign) and hydroxyapatite (malignant) was used in conjunction with simulated mammographic backgrounds, which were generated by fractional Brownian motion of varying roughness and quantified by the Hurst exponent to mimic tissue of varying density...
September 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27344543/variation-in-the-management-of-ductal-carcinoma-in-situ-in-the-uk-results-of-the-mammary-fold-national-practice-survey
#17
(no author information available yet)
INTRODUCTION: Ductal carcinoma in situ (DCIS) accounts for approximately 10% of all newly-diagnosed breast cancers in the UK. The latest national guidelines were published in 2009 and may not reflect current best practice. We aimed to explore variation in the current management of DCIS to support the need for updated guidelines. METHODS: A national practice questionnaire was developed by the Mammary Fold Academic Committee (MFAC) focussing on the pre, intra and post-operative management of DCIS...
August 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27273294/discrimination-of-breast-cancer-with-microcalcifications-on-mammography-by-deep-learning
#18
Jinhua Wang, Xi Yang, Hongmin Cai, Wanchang Tan, Cangzheng Jin, Li Li
Microcalcification is an effective indicator of early breast cancer. To improve the diagnostic accuracy of microcalcifications, this study evaluates the performance of deep learning-based models on large datasets for its discrimination. A semi-automated segmentation method was used to characterize all microcalcifications. A discrimination classifier model was constructed to assess the accuracies of microcalcifications and breast masses, either in isolation or combination, for classifying breast lesions. Performances were compared to benchmark models...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27160829/imaging-performance-of-phase-contrast-breast-computed-tomography-with-synchrotron-radiation-and-a-cdte-photon-counting-detector
#19
A Sarno, G Mettivier, B Golosio, P Oliva, G Spandre, F Di Lillo, C Fedon, R Longo, P Russo
PURPOSE: Within the SYRMA-CT collaboration based at the ELETTRA synchrotron radiation (SR) facility the authors investigated the imaging performance of the phase-contrast computed tomography (CT) system dedicated to monochromatic in vivo 3D imaging of the female breast, for breast cancer diagnosis. METHODS: Test objects were imaged at 38keV using monochromatic SR and a high-resolution CdTe photon-counting detector. Signal and noise performance were evaluated using modulation transfer function (MTF) and noise power spectrum...
May 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27123266/b3-lesions-of-the-breast-and-cancer-risk-an-analysis-of-mammography-screening-patients
#20
Oliver Hoffmann, Gesina Athina Stamatis, Ann-Kathrin Bittner, Georg Arnold, Rolf Schnabel, Karlgeorg Krüger, Rainer Kimmig, Martin Heubner
The use of mammography screening, followed by needle core biopsy (NCB), is associated with an increasing amount of invasive procedures. A considerable amount of specimens must be classified as lesions with uncertain malignant potential (B3-lesion). In these cases, an open biopsy is indicated for further diagnosis. We evaluated patients with B3-lesions to determine the risk of malignancy corresponding to the histopathological NCB results and the type of radiological lesion identified. A total of 95 patients participating in the German mammography screening program with a B3-lesion following NCB (104 B3-lesions in total) were included in our analysis...
May 2016: Molecular and Clinical Oncology
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