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Breast cancer and microcalcification

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https://www.readbyqxmd.com/read/29786482/human-epidermal-growth-factor-2-positive-breast-cancer-with-mammographic-microcalcification-relationship-to-pathologic-complete-response-after-neoadjuvant-chemotherapy
#1
Fayyaz A K Mazari, Nisha Sharma, David Dodwell, Kieran Horgan
Purpose To determine the relationship between the presence or absence of mammographic calcifications in human epidermal growth factor receptor 2 (HER2)-positive breast cancers and pathologic complete response (pCR) to neoadjuvant chemotherapy and to determine other tumor and clinical characteristics that may be predictive of such a response. Materials and Methods A database of all patients with HER2-positive breast cancer who underwent neoadjuvant chemotherapy between 2007 and 2015 was retrospectively reviewed...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29772934/image-guided-vacuum-assisted-breast-biopsy-in-the-diagnosis-of-breast-microcalcifications
#2
Jun Liu, Linping Huang
Objective The present study was performed to assess the accuracy and clinical value of image-guided vacuum-assisted breast biopsy in the diagnosis of mammography-detected breast microcalcifications. Methods This prospective study involved 100 patients with suspicious mammography-detected microcalcifications who underwent image-guided vacuum-assisted breast biopsies from January 2013 to October 2016. Stereotactic vacuum-assisted breast biopsy (SVAB) was performed in 64 patients, and ultrasound (US)-guided vacuum-assisted breast biopsy (US-VAB) was performed in 36 patients in whom application of SVAB was difficult...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29764199/change-in-microcalcifications-on-mammography-after-neoadjuvant-chemotherapy-in-breast-cancer-patients-correlation-with-tumor-response-grade-and-comparison-with-lesion-extent
#3
Hyunee Yim, Taeyang Ha, Doo Kyoung Kang, Seong Young Park, Yongsik Jung, Tae Hee Kim
Background After neoadjuvant chemotherapy (NAC), persistent microcalcifications are often observed in spite of a decrease in the primary tumor size. Purpose To analyze the changes in microcalcifications after NAC and to evaluate the accuracy of residual microcalcifications in predicting the extent of residual cancer. Material and Methods Eighty patients who received NAC and underwent both mammography and magnetic resonance imaging (MRI) before and after the completion of NAC were included. The location of microcalcifications was classified into two types: inside the mass and outside the mass...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29761698/assessment-of-compressive-raman-versus-hyperspectral-raman-for-microcalcification-chemical-imaging
#4
Camille Scotté, Hilton B de Aguiar, Didier Marguet, Ellen Marie Green, Pascaline Bouzy, Sébastien Vergnole, Charles Peter Winlove, Nicholas Stone, Herve Rigneault
We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are generated with an algorithm based on the Cramer-Rao lower bound. We com-pared the developed CRT microspectrometer with two conventional state-of-the-art Raman hyperspectral imaging systems on samples mimicking microcalcifications relevant for breast cancer diagnosis...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29744755/radiological-histological-and-chemical-analysis-of-breast-microcalcifications-diagnostic-value-and-biological-significance
#5
Rita Bonfiglio, Manuel Scimeca, Nicola Toschi, Chiara Adriana Pistolese, Elena Giannini, Chiara Antonacci, Sara Ciuffa, Virginia Tancredi, Umberto Tarantino, Loredana Albonici, Elena Bonanno
Classification of mammary microcalcifications is based on radiological and histological characteristics that are routinely evaluated during the diagnostic path for the identification of breast cancer, or in patients at risk of developing breast cancer. The main aim of this study was to explore the relationship between the imaging parameters most commonly used for the study of mammary microcalcifications and the corresponding histological and chemical properties. To this end, we matched the radiographic characteristics of microcalcifications to breast lesion type, histology of microcalcifications and elemental composition of microcalcifications as obtained by energy dispersive x ray (EDX)-microanalysis...
May 9, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29730729/incorporation-of-the-technologist-s-opinion-for-arbitration-of-discrepant-assessments-among-radiologists-at-screening-mammography
#6
Angela M P Coolen, Joost R C Lameijer, Adri C Voogd, Luc J Strobbe, Marieke W J Louwman, Vivianne C G Tjan-Heijnen, Lucien E M Duijm
PURPOSE: We determined whether the addition of the technologist's opinion may be helpful in deciding if discordant readings at blinded double reading should be recalled. METHODS: A consecutive series of 99,013 digital screening mammograms, obtained between July 2013 and January 2015, were included. All mammograms were first interpreted by a technologist and then double read in a blinded fashion by a team of 13 screening radiologists. All concordant and discordant positive readings among radiologists were recalled...
May 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29703689/comparing-accuracy-of-mammography-and-magnetic-resonance-imaging-for-residual-calcified-lesions-in-breast-cancer-patients-undergoing-neoadjuvant-systemic-therapy
#7
Eunhae Um, Ji-Won Kang, SaeByul Lee, Hee Jeong Kim, Tae In Yoon, Guiyun Sohn, Il Yong Chung, Jisun Kim, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Beom Seok Ko
BACKGROUND: Neoadjuvant systemic therapy (NST) is performed to increase the rate of breast-conserving surgery in advanced breast cancer patients. Although magnetic resonance imaging (MRI) is accurate in predicting residual cancer, if calcification remains, the issue of whether to perform the surgery on the basis of the residual tumor prediction range in mammography (MMG) or MRI has not yet been elucidated. This study aimed to estimate the accuracy of predicting residual tumor after NST for residual microcalcification on mammographic and enhancing lesion on MRI...
March 15, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29684522/microcalcifications-in-breast-cancer-from-pathophysiology-to-diagnosis-and-prognosis
#8
REVIEW
S O'Grady, M P Morgan
The implementation of mammographic screening programmes in many countries has been linked to a marked increase in early detection and improved prognosis for breast cancer patients. Breast tumours can be detected by assessing several features in mammographic images but one of the most common are the presence of small deposits of calcium known as microcalcifications, which in many cases may be the only detectable sign of a breast tumour. In addition to their efficacy in the detection of breast cancer, the presence of microcalcifications within a breast tumour may also convey useful prognostic information...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29665448/all-pure-flat-atypical-atypia-lesions-of-the-breast-diagnosed-using-percutaneous-vacuum-assisted-breast-biopsy-do-not-need-surgical-excision
#9
Lobna Ouldamer, Elodie Poisson, Flavie Arbion, Carole Bonneau, Anne Vildé, Gilles Body, Patrick Michenet
BACKGROUND: The purposes of this study were to evaluate the outcome of women with pure flat atypical atypia (FEA) diagnosed at vacuum-assisted breast biopsy (VABB) targeting microcalcifications and to determine whether clinical, radiological and pathologic parameters are able to predict which lesions will be upgraded to malignancy. MATERIALS: 2414 cases of consecutive VABB for microcalcifications using VA 8-, 10- or 11-Gauge stereotactically guided core biopsy performed between January 2005 and December 2011 from two french breast cancer centers were evaluated...
April 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29657941/investigation-of-frequency-distribution-of-breast-imaging-reporting-and-data-system-birads-classification-and-epidemiological-factors-related-to-breast-cancer-in-iran-a-7-year-study-2010-2016
#10
Mehri Sirous, Parisa Sotoodeh Shahnani, Amirmasoud Sirous
Background: The first cause of women mortality due to cancer is breast cancer. Mammography plays a central part in early detection of breast cancers. The screening methods can play a major role to reduce the morbidity and mortality rate due to this malignancy. We sought the basic data in this study on our population because knowing about the baseline data is apt and vital. Materials and Methods: In this study, data were collected from a questionnaire, contained baseline bio data information, and mammographic imaging of the patients came during 7 years...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29582632/accuracy-of-specimen-radiography-in-assessing-complete-local-excision-with-breast-conservation-surgery
#11
Saira Naz, Imrana Masroor, Shaista Afzal, Waseem Mirza, Sehrish Butt, Zafar Sajjad, Anwar Ahmad
Objective: The aim of this study was to evaluate the accuracy of “X- ray examination of surgically resected specimen‘‘ in assessing complete local excision (CLE). Materials and Methods: In this retrospective cross sectional study, data were collected for all female breast cancer cases who underwent breast-conserving surgery after needle localization of mammographically visible disease. Males, patients with mammographically invisible disease and cases with benign or inconclusive histopathology, those undergoing modified radical mastectomy and individuals with dense breast parenchyma were excluded...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29552533/impact-of-addition-of-digital-breast-tomosynthesis-to-digital-mammography-in-lesion-characterization-in-breast-cancer-patients
#12
Namita Mohindra, Zafar Neyaz, Vinita Agrawal, Gaurav Agarwal, Prabhakar Mishra
Context: Digital breast tomosynthesis (DBT) is a new development in mammography technology which reduces the effect of overlapping tissue. Aims: The aim is to interrogate whether addition of DBT to digital mammography (DM) helps in better characterization of mammographic abnormalities in breast cancer patients in general and in different breast compositions. Settings and Design: Retrospective, analytical cross-sectional study. Subjects and Methods: Mammographic findings in 164 patients with 170 pathologically proven lesions were evaluated by using first DM alone and thereafter with addition of DBT to DM...
January 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29501020/a-unique-case-of-total-metastatic-lobular-breast-carcinoma-originating-from-diffused-microcalcifications-presented-in-a-postmenopausal-woman-without-clinical-manifestations
#13
Athanasios Douskos, Aris Giannos, Sofoklis Stavrou, Maria Sotiropoulou, Eleni Feida, Constantine Dimitrakakis, Peter Drakakis, Alexandros Rodolakis
INTRODUCTION: Lobular breast carcinoma includes lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC). The association of LCIS with total metastatic lobular breast cancer is very rare. PRESENTATION OF CASE: We present a case of a totally metastatic lobular breast cancer in an asymptomatic 64-year-old postmenopausal woman, with no suspicious microcalcifications in mammography. A total hysterectomy with bilateral salpingo-oophorectomy, pelvic lymphadenectomy, infracolic omentectomy and appendectomy was performed along with a quadrantectomy of the upper outer quadrant of left breast, and systematic isolateral lymphadenectomy of the left axilla...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29467479/flat-epithelial-atypia-in-directional-vacuum-assisted-biopsy-of-breast-microcalcifications-surgical-excision-may-not-be-necessary
#14
Zulfia McCroskey, Nour Sneige, Carolyn R Herman, Ross A Miller, Luz A Venta, Jae Y Ro, Mary R Schwartz, Alberto G Ayala
The aim of this study was to analyze the clinicopathological features of patients with flat epithelial atypia, diagnosed in directional vacuum-assisted biopsy targeting microcalcifications, to identify upgrade rate to in situ ductal or invasive breast carcinoma, and determine factors predicting carcinoma in the subsequent excision. We retrospectively evaluated the histological, clinical, and mammographic features of 69 cases from 65 women, with directional vacuum-assisted biopsy-diagnosed flat epithelial atypia with or without atypical ductal hyperplasia or atypical lobular hyperplasia, which underwent subsequent surgical excision...
February 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29465744/baseline-factors-predicting-a-response-to-neoadjuvant-chemotherapy-with-implications-for-non-surgical-management-of-triple-negative-breast-cancer
#15
R F D van la Parra, A B Tadros, C M Checka, G M Rauch, A Lucci, B D Smith, S Krishnamurthy, V Valero, W T Yang, H M Kuerer
BACKGROUND: Patients with triple-negative breast cancer (TNBC) and a pathological complete response (pCR) after neoadjuvant chemotherapy may be suitable for non-surgical management. The goal of this study was to identify baseline clinicopathological variables that are associated with residual disease, and to evaluate the effect of neoadjuvant chemotherapy on both the invasive and ductal carcinoma in situ (DCIS) components in TNBC. METHODS: Patients with TNBC treated with neoadjuvant chemotherapy followed by surgical resection were identified...
April 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29451396/vacuum-assisted-breast-biopsy-vab-excision-of-subcentimeter-microcalcifications-as-an-alternative-to-open-biopsy-for-atypical-ductal-hyperplasia
#16
Simone Schiaffino, Elena Massone, Licia Gristina, Piero Fregatti, Giuseppe Rescinito, Alessandro Villa, Daniele Friedman, Massimo Calabrese
OBJECTIVE: Atypical ductal hyperplasia (ADH) is a proliferative lesion associated with a variable increased risk of breast malignancy, but the management of the patients is still not completely defined, with mandatory surgical excision in most cases. To report the results of the conservative management with mammographic checks of patients with ADH diagnosed by vacuum assisted breast biopsy (VAB), without residual calcifications. METHODS: The authors accessed the institutional database of radiological, surgical and pathological anatomy...
May 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29398324/risk-factors-for-the-development-of-invasive-cancer-in-unresected-ductal-carcinoma-in-situ
#17
Anthony J Maxwell, Karen Clements, Bridget Hilton, David J Dodwell, Andrew Evans, Olive Kearins, Sarah E Pinder, Jeremy Thomas, Matthew G Wallis, Alastair M Thompson
BACKGROUND: The natural history of ductal carcinoma in situ (DCIS) remains uncertain. The risk factors for the development of invasive cancer in unresected DCIS are unclear. METHODS: Women diagnosed with DCIS on needle biopsy after 1997 who did not undergo surgical resection for ≥1 year after diagnosis were identified by breast centres and the cancer registry and outcomes were reviewed. RESULTS: Eighty-nine women with DCIS diagnosed 1998-2010 were identified...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29394840/-examination-of-stereotactic-mammotome-biopsy-for-microcalcification-in-our-hospital
#18
Noriko Sueoka, Mariko Ishizuka, Katsuhiro Yoshikawa, Yu Tsubota, Daigo Yamamoto, Masanori Kon
We introduced stereotactic mammotome biopsy(ST-MMT)for the purpose of screening and other institutions. There are many benign cases to be diagnosed by pathological findings, so it is thought to be necessary to examine the adaptation of STMMT again. We examined the performance of ST-MMT in a case of a non-palpating calcification lesion. Between August 2013 and December 2016, ST-MMT biopsies were performed for 247 microcalcified lesions revealed by mammography(in both breasts in 9 patients; twice in the ipsilateral breast in 2 patients)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29374322/diagnosis-of-breast-cancer-based-on-microcalcifications-using-grating-based-phase-contrast-ct
#19
Xinbin Li, Hewei Gao, Zhiqiang Chen, Li Zhang, Xiaohua Zhu, Shengping Wang, Weijun Peng
OBJECTIVES: Microcalcifications are an important feature in the diagnosis of breast cancer, especially in the early stages. In this paper, a CT-based method is proposed to potentially distinguish benign and malignant breast diseases based on the distributions of microcalcifications using grating-based phase-contrast imaging on a conventional X-ray tube. METHODS: The method presented based on the ratio of dark-field signals to attenuation signals in CT images is compared with the existing method based on the ratio in projections, and the threshold for the classification of microcalcifications in the two types of breast diseases is obtained using our approach...
January 26, 2018: European Radiology
https://www.readbyqxmd.com/read/29247886/microcalcification-morphological-descriptors-and-parenchyma-fractal-dimension-hierarchically-interact-in-breast-cancer-a-diagnostic-perspective
#20
Garima Verma, Maria Laura Luciani, Alessandro Palombo, Linda Metaxa, Giovanna Panzironi, Federica Pediconi, Alessandro Giuliani, Mariano Bizzarri, Virginia Todde
INTRODUCTION: Herein, we propose a Systems Biology approach aimed at identifying quantitative morphological parameters useful in discriminating benign from malignant breast microcalcifications at digital mammography. MATERIALS AND METHODS: The study includes 31 patients in which microcalcifications had been detected during XR mammography and were further confirmed by stereotactic (XR-guided) biopsies. Patients were classified according to the BIRADS (Breast Imaging-Reporting and Data System), along with their parenchyma fractal dimension and biopsy size...
February 1, 2018: Computers in Biology and Medicine
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