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Breast cancer and microcalcification

Matthew E Brice, Marisa Gossweiler, Larry Bennett
Artifacts are universal across all imaging modalities, varying in their conspicuity and significance. In this report three patients with pathology-proven breast cancer who had densities masquerading as microcalcifications at the resection margins of the lumpectomy specimens, but had negative microscopic margins, will be discussed. It was determined that these pseudocalcifications were the result of ink precipitates from a commonly utilized tissue marking dye. This artifact was further evaluated and reproduced by utilizing a boneless chicken breast as a phantom...
October 13, 2016: Radiology
S C Hawkins, I Brown, P King, M El-Gammal, K Stepp, S Widdison, M Barta, N Jackson, P Drew
INTRODUCTION: Wire guided localisation (WGL) is the standard localisation technique for impalpable breast lesions. Radio-guided occult lesion localisation (ROLL) has been proposed as an alternative. We have been performing ROLL for therapeutic wide local excisions (WLE) and diagnostic excision biopsies (DEB) for the last 15 years. We present the largest reported consecutive series of ROLL excisions to date. PATIENTS AND METHODS: One thousand thirty nine consecutive patients who underwent ROLL for impalpable breast lesions were identified from a prospectively collected database...
September 9, 2016: European Journal of Surgical Oncology
Hongjun Li, Shanhua Zhang, Qingyuan Wang, Rongguang Zhu
OBJECTIVE: To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS: A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagnosis and Pathology diagnosis in breast lump, and the detection of microcalcifications, phyllode, and observe the image performance of mammography...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Miyuki Kanematsu, Masami Morimoto, Masako Takahashi, Junko Honda, Yoshimi Bando, Takuya Moriya, Yukiko Tadokoro, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida, Hiroaki Toba, Mitsuteru Yoshida, Aiichiro Kajikawa, Akira Tangoku, Issei Imoto, Mitsunori Sasa
Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis...
2016: Journal of Medical Investigation: JMI
Wioletta Ślusarczyk-Kacprzyk, Witold Skrzyński, Ewa Fabiszewska
BACKGROUND: Different methods of image quality evaluation are routinely used for analogue and digital mammography systems in Poland. In the present study, image quality for several screen-film (SF), computed radiography (CR), and fully digital (DR) mammography systems was compared directly with the use of the ACR mammography accreditation phantom. MATERIAL/METHODS: Image quality and mean glandular doses were measured and compared for 47 mammography systems in the Mazovia Voivodeship in Poland, including 26 SF systems, 12 CR systems, and 9 DR systems...
2016: Polish Journal of Radiology
Yun-Chung Cheung, Yu-Hsiang Juan, Yu-Ching Lin, Yung-Feng Lo, Hsiu-Pei Tsai, Shir-Hwa Ueng, Shin-Cheh Chen
BACKGROUND: Mammography screening is a cost-efficient modality with high sensitivity for detecting impalpable cancer with microcalcifications, and results in reduced mortality rates. However, the probability of finding microcalcifications without associated cancerous masses varies. We retrospectively evaluated the diagnosis and cancer probability of the non-mass screened microcalcifications by dual-energy contrast-enhanced spectral mammography (DE-CESM). PATIENTS AND METHODS: With ethical approval from our hospital, we enrolled the cases of DE-CESM for analysis under the following inclusion criteria: (1) referrals due to screened BI-RADS 4 microcalcifications; (2) having DE-CESM prior to stereotactic biopsy; (3) no associated mass found by sonography and physical examination; and (4) pathology-based diagnosis using stereotactic vacuum-assisted breast biopsy...
2016: PloS One
Almir G V Bitencourt, Eduardo N P Lima, Bruna R C Macedo, Jorge L F A Conrado, Elvira F Marques, Rubens Chojniak
OBJECTIVE: To evaluate the diagnostic accuracy of positron emission mammography (PEM) for identifying malignant lesions in patients with suspicious microcalcifications detected on mammography. METHODS: A prospective, single-centre study that evaluated 40 patients with suspicious calcifications at mammography and indication for percutaneous or surgical biopsy, with mean age of 56.4 years (range: 28-81 years). Patients who agreed to participate in the study underwent PEM with 18F-fluorodeoxyglucose before the final histological evaluation...
September 2, 2016: European Radiology
Joana Diz, Goreti Marreiros, Alberto Freitas
In the field of breast cancer research, and more than ever, new computer aided diagnosis based systems have been developed aiming to reduce diagnostic tests false-positives. Within this work, we present a data mining based approach which might support oncologists in the process of breast cancer classification and diagnosis. The present study aims to compare two breast cancer datasets and find the best methods in predicting benign/malignant lesions, breast density classification, and even for finding identification (mass / microcalcification distinction)...
September 2016: Journal of Medical Systems
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
BACKGROUND AND OBJECTIVES: Secreted protein, acidic and rich in cysteine (SPARC) is able to play an important role in cancer invasion due to de-adhesive properties and impact on stromal remodeling. The aim of study was to investigate SPARC expression in preoperatively diagnosed breast DCIS and to assess its predictive value for the final invasion. METHODS: A total of 209 patients with DCIS found on stereotactic vacuum-assisted biopsy of suspicious microcalcifications were studied prospectively...
July 20, 2016: Journal of Surgical Oncology
Giovanna Mariscotti, Paolo Belli, Daniela Bernardi, Beniamino Brancato, Massimo Calabrese, Luca A Carbonaro, Beatrice Cavallo-Marincola, Francesca Caumo, Paola Clauser, Laura Martinchich, Stefania Montemezzi, Pietro Panizza, Federica Pediconi, Alberto Tagliafico, Rubina M Trimboli, Chiara Zuiani, Francesco Sardanelli
Women who underwent chest radiation therapy (CRT) during pediatric/young-adult age (typically, lymphoma survivors) have an increased breast cancer risk, in particular for high doses. The cumulative incidence from 40 to 45 years of age is 13-20 %, similar to that of BRCA mutation carriers for whom contrast-enhanced magnetic resonance imaging (MRI) is recommended. However, in women who underwent CRT, MRI sensitivity is lower (63-80 %) and that of mammography higher (67-70 %) than those observed in women with hereditary predisposition, due to a higher incidence of ductal carcinoma in situ with microcalcifications and low neoangiogenesis...
July 12, 2016: La Radiologia Medica
Shayne M Plourde, Zach Marin, Zachary R Smith, Brian C Toner, Kendra A Batchelder, Andre Khalil
BACKGROUND: When screening for breast cancer, the radiological interpretation of mammograms is a difficult task, particularly when classifying precancerous growth such as microcalcifications (MCs). Biophysical modeling of benign vs. malignant growth of MCs in simulated mammographic backgrounds may improve characterization of these structures METHODS: A mathematical model based on crystal growth rules for calcium oxide (benign) and hydroxyapatite (malignant) was used in conjunction with simulated mammographic backgrounds, which were generated by fractional Brownian motion of varying roughness and quantified by the Hurst exponent to mimic tissue of varying density...
September 1, 2016: Computers in Biology and Medicine
(no author information available yet)
INTRODUCTION: Ductal carcinoma in situ (DCIS) accounts for approximately 10% of all newly-diagnosed breast cancers in the UK. The latest national guidelines were published in 2009 and may not reflect current best practice. We aimed to explore variation in the current management of DCIS to support the need for updated guidelines. METHODS: A national practice questionnaire was developed by the Mammary Fold Academic Committee (MFAC) focussing on the pre, intra and post-operative management of DCIS...
August 2016: European Journal of Surgical Oncology
Jinhua Wang, Xi Yang, Hongmin Cai, Wanchang Tan, Cangzheng Jin, Li Li
Microcalcification is an effective indicator of early breast cancer. To improve the diagnostic accuracy of microcalcifications, this study evaluates the performance of deep learning-based models on large datasets for its discrimination. A semi-automated segmentation method was used to characterize all microcalcifications. A discrimination classifier model was constructed to assess the accuracies of microcalcifications and breast masses, either in isolation or combination, for classifying breast lesions. Performances were compared to benchmark models...
2016: Scientific Reports
A Sarno, G Mettivier, B Golosio, P Oliva, G Spandre, F Di Lillo, C Fedon, R Longo, P Russo
PURPOSE: Within the SYRMA-CT collaboration based at the ELETTRA synchrotron radiation (SR) facility the authors investigated the imaging performance of the phase-contrast computed tomography (CT) system dedicated to monochromatic in vivo 3D imaging of the female breast, for breast cancer diagnosis. METHODS: Test objects were imaged at 38keV using monochromatic SR and a high-resolution CdTe photon-counting detector. Signal and noise performance were evaluated using modulation transfer function (MTF) and noise power spectrum...
May 2016: Physica Medica: PM
Oliver Hoffmann, Gesina Athina Stamatis, Ann-Kathrin Bittner, Georg Arnold, Rolf Schnabel, Karlgeorg Krüger, Rainer Kimmig, Martin Heubner
The use of mammography screening, followed by needle core biopsy (NCB), is associated with an increasing amount of invasive procedures. A considerable amount of specimens must be classified as lesions with uncertain malignant potential (B3-lesion). In these cases, an open biopsy is indicated for further diagnosis. We evaluated patients with B3-lesions to determine the risk of malignancy corresponding to the histopathological NCB results and the type of radiological lesion identified. A total of 95 patients participating in the German mammography screening program with a B3-lesion following NCB (104 B3-lesions in total) were included in our analysis...
May 2016: Molecular and Clinical Oncology
Hirohito Seki, Kenichi Sasaki, Shojiro Morinaga, Fumiki Asanuma, Hisashi Yanaihara, Munehisa Kaneda, Keiichi Suzuki, Yoshiyuki Ishii, Noriki Kamiya, Masayoshi Osaku, Tadashi Ikeda
A 48-year-old woman had a left breast mass identified during routine breast cancer screening. The mammogram showed pleomorphic-segmental microcalcifications in the mediolateral-oblique view of the left breast. Ultrasonography showed a hypoechoic mass approximately 3.7 cm in diameter with multiple calcifications. Contrast-enhanced magnetic resonance imaging of the breast showed non-mass like enhancement of approximately 4 cm in diameter in the C area of the left breast. She was diagnosed with glycogen-rich clear cell carcinoma (GRCC) by ultrasound-guided vacuum-assisted biopsy...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Xiaoyong Zhang, Noriyasu Homma, Shotaro Goto, Yosuke Kawasumi, Tadashi Ishibashi, Makoto Abe, Norihiro Sugita, Makoto Yoshizawa
The presence of microcalcification clusters (MCs) in mammogram is a major indicator of breast cancer. Detection of an MC is one of the key issues for breast cancer control. In this paper, we present a highly accurate method based on a morphological image processing and wavelet transform technique to detect the MCs in mammograms. The microcalcifications are firstly enhanced by using multistructure elements morphological processing. Then, the candidates of microcalcifications are refined by a multilevel wavelet reconstruction approach...
2013: Journal of Medical Engineering
Marga B Rominger, Carolin Steinmetz, Ronny Westerman, Annette Ramaswamy, Ute-Susann Albert
INTRODUCTION: In this study we evaluated mammographic, histological and immunohistochemical findings for microcalcification-associated breast cancer with regards to breast-conserving therapy, recurrence and survival rate. PATIENTS AND METHODS: We retrospectively analyzed 99 consecutive, non-palpable and microcalcification-associated breast cancers (94 women) that were treated surgically between January 2002 and December 2003 at a national academic breast cancer center...
December 2015: Breast Care
Bartlomiej Szynglarewicz, Adam Maciejczyk, Jozef Forgacz, Rafal Matkowski
BACKGROUND: The aim of this study was to assess the usefulness of the breast segmentectomy with rotation mammoplasty (BSRMP) in conserving therapy for an extensive ductal carcinoma in situ (DCIS) with or without an invasive component. METHODS: Thirty-six women with DCIS visible as large area of microcalcifications distributed out of the retroareolar area regardless of the quadrant were studied prospectively. All the patients underwent BSRMP and axillary procedure (31 sentinel node biopsy, 5 axillary dissection) followed by radiotherapy...
2016: World Journal of Surgical Oncology
O Golan, Y Amitai, T Menes
AIM: To determine whether change in microcalcification density and extent after neoadjuvant treatment (NAT) can predict tumour response. MATERIALS AND METHODS: This single-institution, retrospective study included all women with breast cancer who underwent NAT between 1 January 2008 and 31 December 2014, and fulfilled the following criteria: mammography before NAT with pathological microcalcifications, mammography performed after NAT, and tumour resection at Tel-Aviv Sourasky Medical Center...
May 2016: Clinical Radiology
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