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https://www.readbyqxmd.com/read/28636060/developing-mobile-clinical-decision-support-for-nursing-home-staff-assessment-of-urinary-tract-infection-using-goal-directed-design
#1
Wallace Jones, Cynthia Drake, David Mack, Blaine Reeder, Barbara Trautner, Heidi Wald
BACKGROUND: Unique characteristics of nursing homes (NHs) contribute to high rates of inappropriate antibiotic use for asymptomatic bacteriuria (ASB), a benign condition. A mobile clinical decision support system (CDSS) may support NH staff in differentiating urinary tract infections (UTI) from ASB and reducing antibiotic days. OBJECTIVES: We used Goal-Directed Design to: 1) Characterize information needs for UTI identification and management in NHs; 2) Develop UTI Decide, a mobile CDSS prototype informed by personas and scenarios of use constructed from Aim 1 findings; 3) Evaluate the UTI Decide prototype with NH staff...
June 20, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28624753/treatment-of-asymptomatic-uti-in-older-delirious-medical-in-patients-a-prospective-cohort-study
#2
Monidipa Dasgupta, Chris Brymer, Sameer Elsayed
BACKGROUND: Despite clinical practice guidelines, asymptomatic bacteriuria (ASB) in older people is frequently treated. A common reason for treating ASB is a change in mental status. OBJECTIVE: To determine how often asymptomatic UTI is treated in older medically ill delirious individuals and its association with functional recovery. METHODS: Consecutive older medical in-patients were screened for delirium, and followed in hospital. Treatment for asymptomatic UTI was defined as documented treatment for a possible urinary tract infection with antibiotics, without concurrent infectious or urinary symptoms...
May 31, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28618051/quantitative-bioanalysis-of-bavachalcone-in-rat-plasma-by-lc-ms-ms-and-its-application-in-a-pharmacokinetics-study
#3
Dan Zhou, Lianhua An, Yan Xia, Yuanyi Wang, Xingliang Li
This study aims to develop and validate a simple and sensitive liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for investigating the pharmacokinetic characteristics of bavachalcone. Liquid-liquid extraction was used to prepare plasma sample. Chromatographic separation of bavachalcone and IS was achieved by using a Venusil ASB C18 (2.1 × 50 mm, 5 μm) column with a mobile phase of methanol (A)-water (B) (70:30, v/v). The detection and quantification of analytes was performed in selected-reaction monitoring mode using precursor→product ion combinations of m/z 323...
June 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28586472/maternal-consumption-of-artificially-sweetened-beverages-during-pregnancy-and-offspring-growth-through-7-years-of-age-a-prospective-cohort-study
#4
Yeyi Zhu, Sjurdur F Olsen, Pauline Mendola, Thorhallur I Halldorsson, Shristi Rawal, Stefanie N Hinkle, Edwina H Yeung, Jorge E Chavarro, Louise G Grunnet, Charlotta Granström, Anne A Bjerregaard, Frank B Hu, Cuilin Zhang
Background: Artificial sweeteners are widely replacing caloric sweeteners. Data on long-term impact of artificially sweetened beverage (ASB) consumption during pregnancy on offspring obesity risk are lacking. We prospectively investigated intake of ASBs and sugar-sweetened beverages (SSBs) during pregnancy in relation to offspring growth through age 7 years among high-risk children born to women with gestational diabetes. Methods: In a prospective study of 918 mother-singleton child dyads from the Danish National Birth Cohort, maternal dietary intake was assessed by a food frequency questionnaire during pregnancy...
June 6, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28555534/personality-risk-for-antisocial-behavior-testing-the-intersections-between-callous-unemotional-traits-sensation-seeking-and-impulse-control-in-adolescence
#5
Frank D Mann, Sara L Paul, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
The current project seeks to integrate literatures on personality risk for antisocial behavior (ASB) by examining how callous-unemotional traits relate to (a) the development of disinhibited traits and (b) the association between disinhibited traits and ASB. In Study 1, using a nationally representative sample of youth (N > 7,000), we examined whether conduct problems and lack of guilt assessed during ages 4-10 years predicted levels of and changes in disinhibited traits over the course of adolescence, and moderated associations between these traits and ASB...
May 30, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28553665/urinary-arsenic-speciation-in-children-and-pregnant-women-from-spain
#6
Antonio J Signes-Pastor, Manus Carey, Jesus Vioque, Eva M Navarrete-Muñoz, Cristina Rodríguez-Dehli, Adonina Tardón, Miren Begoña-Zubero, Loreto Santa-Marina, Martine Vrijheid, Maribel Casas, Sabrina Llop, Sandra Gonzalez-Palacios, Andrew A Meharg
Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia...
2017: Expo Health
https://www.readbyqxmd.com/read/28551855/characterization-of-a-novel-theme-c-glycoside-hydrolase-family-9-cellulase-and-its-cbm-chimeric-enzymes
#7
Cheng-Jie Duan, Ming-Yue Huang, Hao Pang, Jing Zhao, Chao-Xing Wu, Jia-Xun Feng
In bacterial cellulase systems, glycoside hydrolase family 9 (GH9) cellulases are generally regarded as the major cellulose-degrading factors besides GH48 exoglucanase. In this study, umcel9A, which was cloned from uncultured microorganisms from compost, with the encoded protein being theme C GH9 cellulase, was heterologously expressed in Escherichia coli, and the biochemical properties of the purified enzyme were characterized. Hydrolysis of carboxylmethylcellulose (CMC) by Umcel9A led to the decreased viscosity of CMC solution and production of reducing sugars...
May 27, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28531558/accumulation-translocation-and-conversion-of-six-arsenic-species-in-rice-plants-grown-near-a-mine-impacted-city
#8
Li Ma, Lin Wang, Yuyu Jia, Zhaoguang Yang
Paddy rice (Oryza sativa L.) as the staple food in China was found to be efficient in accumulating arsenic (As) due to cultivated in flooded paddy soil. Uptake and translocation of As in rice plant depended on the As species. In this work, rice plant samples including roots, straws and grains as well as rhizosphere soils were collected from paddy fields near Changsha, a mine impacted city in Southern China. The total As concentrations in the collected samples were observed in the descending order as root > soil > straw > grain...
May 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28531289/management-of-bacteriuria-in-veterans-affairs-hospitals
#9
Emily S Spivak, Muriel Burk, Rongping Zhang, Makoto M Jones, Melinda M Neuhauser, Matthew Bidwell Goetz, Francesca E Cunningham
Background: Bacteriuria contributes to antibiotic overuse through treatment of asymptomatic bacteriuria (ASB) and long durations of therapy for symptomatic urinary tract infections (UTIs), yet large-scale evaluations of bacteriuria management among inpatients are lacking. Methods: Inpatients with bacteriuria were classified as asymptomatic or symptomatic based on established criteria applied to data collected by manual chart review. We examined frequency of treatment of ASB, factors associated with treatment of ASB, durations of therapy, and frequency of complications including Clostridium difficile infection, readmission and all-cause mortality within 28 days of discharge...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28513319/effect-of-surface-functionalizations-of-multi-walled-carbon-nanotubes-on-neoplastic-transformation-potential-in-primary-human-lung-epithelial-cells
#10
Todd A Stueckle, Donna C Davidson, Ray Derk, Peng Wang, Sherri Friend, Diane Schwegler-Berry, Peng Zheng, Nianqiang Wu, Vince Castranova, Yon Rojanasakul, Liying Wang
Functionalized multi-walled carbon nanotube (fMWCNT) development has been intensified to improve their surface activity for numerous applications, and potentially reduce toxic effects. Although MWCNT exposures are associated with lung tumorigenesis in vivo, adverse responses associated with exposure to different fMWCNTs in human lung epithelium are presently unknown. This study hypothesized that different plasma-coating functional groups determine MWCNT neoplastic transformation potential. Using our established model, human primary small airway epithelial cells (pSAECs) were continuously exposed for 8 and 12 weeks at 0...
June 2, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28504358/randomized-controlled-trial-of-functional-family-therapy-for-offending-and-antisocial-behavior-in-uk-youth
#11
Sajid Humayun, Lauren Herlitz, Melanie Chesnokov, Moira Doolan, Sabine Landau, Stephen Scott
BACKGROUND: Youth offending and antisocial behavior (ASB) are associated with low quality mental health and relationships and usually lead to poor adult functioning; they are very costly for society. Family interventions are effective in children but there are few reliably effective and inexpensive interventions for adolescents. Functional Family Therapy (FFT) is an evidence-based intervention but seldom tested outside the United States. METHODS: One hundred and eleven adolescents (10-17 years of age, M = 15...
May 15, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28503352/serum-adiponectin-levels-are-associated-with-microcirculatory-function-but-not-with-coronary-artery-disease-in-the-young
#12
A De Lorenzo, Asb Moreira, E Guimaraes, Gmm Oliveira, E Maia, E V Tibirica
No abstract text is available yet for this article.
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28495907/interdevice-comparison-of-retinal-sensitivity-assessments-in-a-healthy-population-the-centervue-maia-and-the-nidek-mp-3-microperimeters
#13
Siva Balasubramanian, Akihito Uji, Jianqin Lei, Swetha Velaga, Muneeswar Nittala, SriniVas Sadda
BACKGROUND: To compare and correlate the retinal sensitivity measurements obtained with Nidek Microperimetry-3 (MP-3) and the CenterVue Macular Integrity Assessment (MAIA) microperimeters among healthy subjects. METHODS: In this prospective comparative study, 31 eyes of 23 subjects underwent complete ophthalmological examination including retinal sensitivity assessments using two microperimeters, the MP-3 (Nidek Technologies) and the MAIA (CenterVue). The mean retinal sensitivity (dB) and its corresponding luminance (asb) and contrast (log units) were analysed between the two instruments...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28480387/politics-of-biopiracy-an-adventure-into-hoodia-xhoba-patenting-in-southern-africa
#14
Lere Amusan
BACKGROUND: Africa is being described as the wretched of the earth, despite this, the continent is endowed with natural resources, dynamic ecosystem, and different species of plants and animals, and species derivatives. This paper area of departure is to focus on Hoodia, a plant that is being a source of food, medicine and water for the San and Khoe indigenous peoples before the advent of Europeans into southern Africa. South African Council for Scientific and Industrial Research (CSIR) dubiously patented Hoodia without observing the basic indices of geographical indications (GIs), indigenous knowledge (IK), novelty, access sharing benefit (ASB), prior informed consent (PIC) and sustainability of ecosystem before the rights was sold to Phytopharm pharmaceutical company...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28474008/micellization-and-single-particle-encapsulation-with-dimethylammoniopropyl-sulfobetaines
#15
Jianxin Wang, Oscar Morales-Collazo, Alexander Wei
Sulfobetaines (SBs) are a class of zwitterionic surfactants with a reputation for enhancing colloidal stability at high salt concentrations. Here, we present a systematic study on the self-assembly of SB amphiphiles (sultaines or hydroxysultaines) in aqueous solutions, as a function of chain length and composition, ionic strength, and in the presence of alkanethiol-coated Au nanoparticles (GNPs). The diameters of the micelles assembled from SB and amidosulfobetaine (ASB) generally increase monotonically with chain length, although ASB micelles are smaller relative to alkyl SB micelles with similarly sized tailgroups, and oleyl sulfobetaine (OSB) micelles are slightly larger...
April 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28468911/impact-of-two-step-urine-culture-ordering-in-the-emergency-department-a-time-series-analysis
#16
Amanda Stagg, Haydon Lutz, Sakshi Kirpalaney, John Justin Matelski, Adam Kaufman, Jerome Leis, Janine McCready, Jeff Powis
BACKGROUND: Despite evidence against the use of antimicrobials for asymptomatic bacteriuria (ASB), they are frequently prescribed leading to unnecessary adverse events. Prior studies have shown that reducing unnecessary urine cultures (UCs) results in decreased antimicrobial utilisation for ASB. Emergency departments (EDs) submit the largest volume of UCs, yet efforts to limit overordering in this patient setting have had limited success. METHODS: A new two-step model of care for urine collection, using a novel UC collection container, was implemented in the ED of a large community hospital...
May 3, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28451019/prevalence-aetiology-and-antibiotic-sensitivity-profile-of-asymptomatic-bacteriuria-isolates-from-pregnant-women-in-selected-antenatal-clinic-from-nairobi-kenya
#17
Adelaide Ogutu Ayoyi, Gideon Kikuvi, Christine Bii, Samuel Kariuki
INTRODUCTION: Asymptomatic bacteriuria (ASB) is the presence of bacteria in urine without apparent symptoms of urinary tract infections. The importance of asymptomatic bacteriuria lies in the insight it provides into symptomatic infections. To determine prevalence, bacterial isolates and Antibiotic Sensitivity Profile of asymptomatic bacterial urinary tract infection in pregnant women in selected clinics in Nairobi. METHODS: This was a cross-sectional study involving women attending antenatal clinic at selected clinics of Nairobi County...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28444291/pasteurella-aerogenes-as-an-asymptomatic-bacteriuria-agent
#18
Demet Alaygut, Aynur Engin
'Asymptomatic bacteriuria' (ASB) is isolation of a specified quantitative count of bacteria in an appropriately collected urine specimen obtained from a person without symptoms or signs referable to urinary infection. Catheterized specimens are less likely to be contaminated compared with voided specimens; therefore, positive cultures of catheterized specimens are more likely to reflect true bladder bacteriuria even with low colony counts. The common pathogens for ASB are Escherichia coli, Klebsiella and Streptococcus spp...
April 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28422167/biotin-transfer-from-a-trifunctional-crosslinker-for-identification-of-cell-surface-receptors-of-soluble-protein-ligands
#19
Tammy-Lynn Tremblay, Jennifer J Hill
Here we describe a novel crosslinker and its application as a biotin-transfer reagent to identify cell surface receptors of soluble protein ligands on live cells. This crosslinker contains three functional groups: an aldehyde-reactive aminooxy group, a sulfhydryl, and a biotin (ASB). It is readily synthesized via a 3-step addition reaction using standard solid-phase peptide synthesis methods and commercially available intermediates, allowing access to laboratories without specialized synthetic chemistry capabilities...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421867/symptom-related-attributional-biases-in-schizophrenia-and-bipolar-disorder
#20
Nicole Sanford, Todd S Woodward
INTRODUCTION: Biases in causal attributions and evidence integration have been implicated in delusions, but have not been investigated simultaneously to examine additive or multiplicative effects. It was hypothesised that paranoid delusions would correlate with self-serving and personalising biases ("defence" model of paranoia), particularly when these biases were disconfirmed. METHODS: Constrained principal component analysis was used to investigate differences between schizophrenia patients (paranoid vs...
July 2017: Cognitive Neuropsychiatry
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