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https://www.readbyqxmd.com/read/29310737/low-resting-heart-rate-sensation-seeking-and-the-course-of-antisocial-behaviour-across-adolescence-and-young-adulthood
#1
Gemma Hammerton, Jon Heron, Liam Mahedy, Barbara Maughan, Matthew Hickman, Joseph Murray
BACKGROUND: Low resting heart rate (RHR) is a consistent biological correlate of antisocial behaviour (ASB), however potential mechanisms have been largely unexplored. We hypothesise that lower RHR will be associated with higher ASB levels in mid-adolescence and persistence into adulthood, and that these associations will be explained, in part, by sensation seeking and callous-unemotional traits. METHODS: ASB was assessed repeatedly with young people from ages 15 to 21 years in a population-based birth cohort (ALSPAC)...
January 9, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29307512/the-endoc-%C3%AE-h1-cell-line-is-a-valid-model-of-human-beta-cells-and-applicable-for-screenings-to-identify-novel-drug-target-candidates
#2
Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D Madsen, Claude Rescan, Thomas Frogne
OBJECTIVE: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification of novel anti-diabetic drug candidates. METHODS: EndoC-βH1 was transplanted into mice for validation of in vivo functionality. Insulin secretion was evaluated in cells cultured as monolayer and as pseudoislets, as well as in diabetic mice...
December 19, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29289875/a-novel-membrane-bioreactor-inoculated-with-symbiotic-sludge-bacteria-and-algae-performance-and-microbial-community-analysis
#3
Li Sun, Yu Tian, Jun Zhang, Lipin Li, Jian Zhang, Jianzheng Li
This study combined sludge MBR technology with algae to establish an effective wastewater treatment and low membrane fouling system (ASB-MBR). Compared with control-MBR (C-MBR), the amelioration of microbial activity and the improvement of sludge properties and system environment were achieved after introducing algae resulting in high nutrients removal in the combined system. Further statistical analysis revealed that the symbiosis of algae and sludge displayed more remarkable impacts on nutrients removal than either of them...
December 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29243301/evaluation-of-the-live-biotherapeutic-product-asymptomatic-bacteriuria-escherichia-coli-2-12-in-healthy-dogs-and-dogs-with-clinical-recurrent-uti
#4
G Segev, J E Sykes, D J Klumpp, A J Schaeffer, E M Antaki, B A Byrne, R E Yaggie, J L Westropp
BACKGROUND: Antimicrobial resistance is an emerging problem. HYPOTHESIS/OBJECTIVE: To investigate the safety and efficacy of a live biotherapeutic product, ASB E. coli 2-12 for UTI treatment. ANIMALS: Six healthy research dogs; nine client-owned dogs with recurrent UTI. METHODS: Prospective noncontrolled clinical trial. For safety data, research dogs were sedated, a urinary catheter was inserted into the bladder; 1010 CFU/mL of ASB E...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29237319/fibrous-nanocellulose-crystalline-nanocellulose-carbon-nanotubes-and-crocidolite-asbestos-elicit-disparate-immune-responses-upon-pharyngeal-aspiration-in-mice
#5
Eun-Jung Park, Timur O Khaliullin, Michael R Shurin, Elena R Kisin, Naveena Yanamala, Bengt Fadeel, Jaerak Chang, Anna A Shvedova
With the rapid development of synthetic alternatives to mineral fibers, their possible effects on the environment and human health have become recognized as important issues worldwide. This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets...
December 2018: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29228072/an-implementation-guide-to-reducing-overtreatment-of-asymptomatic-bacteriuria
#6
Michael Daniel, Sara Keller, Mohammad Mozafarihashjin, Amit Pahwa, Christine Soong
Treatment of asymptomatic bacteriuria (ASB) frequently lacks appropriate indication, yet remains prevalent across settings. Numerous guidelines, professional societies, and campaigns such as Choosing Wisely advocate against this low-value practice. Efforts aimed at reducing unnecessary treatment of ASB demonstrate improved costs, and avoidable harm without increased risk of adverse events. We propose an evidence-based implementation guide to aid practitioners in reducing inappropriate treatment of ASB.
December 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29226170/inappropriate-management-of-asymptomatic-patients-with-positive-urine-cultures-a-systematic-review-and-meta-analysis
#7
Myrto Eleni Flokas, Nikolaos Andreatos, Michail Alevizakos, Alireza Kalbasi, Pelin Onur, Eleftherios Mylonakis
Background: Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods: We conducted a systematic review and meta-analysis of studies that reported on the rate of inappropriate ASB treatment published from 2004 to August 2016. The appropriateness of antimicrobial administration was based on guidelines published by the Infectious Diseases Society of America...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29186363/transformation-of-visual-representations-across-ventral-stream-body-selective-patches
#8
Satwant Kumar, Ivo D Popivanov, Rufin Vogels
Although the neural processing of visual images of bodies is critical for survival, it is much less well understood than face processing. Functional imaging studies demonstrated body selective regions in primate inferior temporal cortex. To advance our understanding of how the visual brain represents bodies, we compared the representation of animate and inanimate objects in two such body patches with fMRI-guided single unit recordings in rhesus monkeys. We found that the middle Superior Temporal Sulcus body patch (MSB) distinguishes to a greater extent bodies from non-bodies than the anterior Superior Temporal Sulcus body patch (ASB)...
November 23, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29185144/bond-strength-of-adhesive-systems-to-sound-and-demineralized-dentin-treated-with-bioactive-glass-ceramic-suspension
#9
Renata Costa de Morais, Renata Espíndola Silveira, Michelle Chinelatti, Saulo Geraldeli, Fernanda de Carvalho Panzeri Pires-de-Souza
OBJECTIVE: The objective of this study was to evaluate the effect of a Biosilicate®, associated with dentin adhesive system, on microtensile bond strength (μTBS) to sound and demineralized dentin. MATERIALS AND METHODS: Eighty sound-extracted molars had their middle occlusal dentin exposed. In forty teeth, dentin was artificially demineralized (pH cycling). Sound and demineralized dentin teeth were separated into four groups (n = 10), according to the substrate treatment before restoration: Group 1-total-etching adhesive Adper TM Single bond 2 (ASB) + Biosilicate®, Group 2-ASB (without Biosilicate®), Group 3-AdheSE self-etching adhesive system (AdSE) + Biosilicate®, and Group 4-AdSE (without Biosilicate®)...
November 28, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29175405/arsenic-concentrations-and-speciation-in-wild-birds-from-an-abandoned-realgar-mine-in-china
#10
Fen Yang, Shaowen Xie, Jinxin Liu, Chaoyang Wei, Hongzhi Zhang, Tao Chen, Jing Zhang
Birds are at a higher level in the food chain; however, the potential bioaccumulation and biotransformation of arsenic (As) in birds in As mines has rarely been studied. In this study, four passerine bird species (tree sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis], Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were collected from an abandoned As mine in China. The highest recorded As concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and feathers, respectively...
November 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/29174023/antibiotic-treatment-of-asymptomatic-bacteriuria-prior-to-hip-and-knee-arthroplasty-a-systematic-review-of-the-literature
#11
REVIEW
Alistair I W Mayne, Peter S E Davies, James M Simpson
BACKGROUND: There is significant debate as to whether routine antibiotic treatment of asymptomatic bacteriuria (ASB) in arthroplasty patients reduces the risk of subsequent PJI. No previous systematic reviews have been undertaken on this subject. The aim of this systematic review was to investigate whether antibiotic treatment of asymptomatic bacteriuria in arthroplasty patients reduces the risk of prosthetic joint infection and to investigate whether the organisms cultured in peri-operative urine samples are the same as those responsible for subsequent prosthetic joint infections...
November 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29162195/assessing-the-interplay-between-multigenic-and-environmental-influences-on-adolescent-to-adult-pathways-of-antisocial-behaviors
#12
James J Li
The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools)...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29146139/how-to-prevent-renal-cachexia-a-clinical-randomized-pilot-study-testing-oral-supplemental-nutrition-in-hemodialysis-patients-with-and-without-human-immunodeficiency-virus-infection
#13
Michael Zilles, Christoph Betz, Oliver Jung, Stefan Gauer, Renate Hammerstingl, Astrid Wächtershäuser, Thomas J Vogl, Helmut Geiger, Aida Asbe-Vollkopf, Rainer U Pliquett
OBJECTIVE: End-stage renal disease associates with catabolism and sarcopenia. Hypothetically, peroral supplemental nutrition over 6 months prevents catabolism in hemodialysis patients. DESIGN: Prospective randomized pilot study (ClinicalTrials.gov Identifier: NCT00687050). SUBJECTS: Twenty-three hemodialysis patients (15 males and 7 females) with or without human immunodeficiency virus (HIV) infection of 2 ambulatory hemodialysis centers...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29129137/citation-metrics-of-excellence-in-sports-biomechanics-research
#14
Duane Knudson
This study extended research on key citation metrics of winners of two career scholar awards in sports biomechanics. Google Scholar (GS) was searched using Harzing's Publish or Perish software for the 13 most recent winners of the ISBS Geoffrey Dyson Award and the ASB Jim Hay Memorial Award. Returned records were corrected for author, and publications excluded for all but peer-reviewed journal articles, proceedings articles, chapters and books in English. These recent award winners had published about 150 publications that had been cited typically 4,082 and 6,648 times over a 26- and 28-year period before receiving these career awards for sports biomechanics research...
November 13, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/29120787/speciation-analysis-of-six-arsenic-species-in-marketed-shellfish-extraction-optimization-and-health-risk-assessment
#15
Yuyu Jia, Lin Wang, Li Ma, Zhaoguang Yang
A comparative study between microwave assisted and sonication methods was carried out to extract arsenic (As) species in shellfish samples using different extractants. Six As species including arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB) and arsenocholine (AsC) were simultaneously separated and determined by the HPLC-ICP-MS method. The microwave assisted method exhibited higher efficiency than sonication, especially using diluted HNO3 as extractant...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29107038/routine-urine-testing-at-the-spinal-cord-injury-annual-evaluation-leads-to-unnecessary-antibiotic-use-a-pilot-study-and-future-directions
#16
Felicia Skelton, Larissa Grigoryan, Sally Ann Holmes, Ivy Oiyee Poon, Barbara Trautner
OBJECTIVE: To measure the prevalence of ASB in persons with spinal cord injury (SCI) at the time of their annual examination, and examine the impact on urine testing during the annual examination on subsequent antibiotic use. DESIGN: retrospective cohort study SETTING: a major Veterans Health Administration SCI center PARTICIPANTS: Veterans with SCI seen for an outpatient annual evaluation in 2012 or 2013 (n=393) MAIN OUTCOME MEASURE: antibiotic use for bacteriuria within seven days of the annual evaluation encounter RESULTS: Of the 327 clinic visits that met inclusion criteria, of which 249 had a urine culture performed...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29100693/arsenic-biokinetics-and-bioavailability-in-deposit-feeding-clams-and-polychaetes
#17
Wei Zhang, Wen-Xiong Wang
In the present study, the arsenic (As) biokinetics and bioavailability in two deposit-feeding invertebrates (clams Gafrarium tumidum and polychaetes Nereis succinea) were quantified. Radiotracer techniques were applied to measure the dissolved uptake rate, dietary assimilation efficiency and efflux of As by the clams and polychaetes. Simultaneously, arsenic species analysis was conducted to examine the As biotransformation following dietary uptake. The radiotracer results showed that the uptake rate constant and efflux rate constant were 0...
October 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29040879/influence-of-sexual-behavior-of-dorper-rams-treated-with-glutamate-and-or-testosterone-on-reproductive-performance-of-anovulatory-ewes
#18
Guadalupe Calderón-Leyva, Cesar A Meza-Herrera, Rafael Rodriguez-Martinez, Oscar Angel-García, Raymundo Rivas-Muñoz, Juan V Delgado-Bermejo, Francisco G Véliz-Deras
The aim of this study was to determine if exogenous administration of glutamate and (or) testosterone to male rams during the season of reproductive arrest is able to re-activate male sexual behavior and, later on, to promote through the male effect, both sexual and reproductive competence of anovulatory nulliparous ewes. Therefore, an experiment was performed under long-day photoperiods (spring; photo-reproductive arrest, 26°N). Dorper rams were randomly divided into four homogeneous experimental groups (n = 5 males each) regarding live weight (LW), body condition score (BCS), scrotal circumference (SC) and odor intensity (OI)...
January 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29029779/redefining-the-abdominal-seatbelt-sign-enhanced-ct-imaging-metrics-improve-injury-prediction
#19
Michael C Johnson, Brian J Eastridge
INTRODUCTION: The abdominal seatbelt sign (ASBS) has an established association with abdominal injury, yet its definition remains ill-defined. We hypothesize specific imaging characteristics associated with the ASBS such as location above the pelvic brim and depth of abdominal wall contusion would better predict underlying injury and need for operative intervention. METHODS: We performed a retrospective chart review of subjects suffering from restrained motor vehicle collisions (MVC) evaluated at a level one trauma facility from 2010 to 2015...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28983456/enzyme-replacement-therapy-attenuates-disease-progression-in-two-japanese-siblings-with-mucopolysaccharidosis-type-vi-10-year-follow-up
#20
Mahoko Furujo, Motomichi Kosuga, Torayuki Okuyama
Early initiation of enzyme replacement therapy (ERT) has demonstrated clinical benefit in patients with mucopolysaccharidosis type VI (MPS VI), a progressive, multisystem autosomal recessive lysosomal disorder caused by N-acetylgalactosamine-4-sulphatase (ASB) deficiency and the consequent accumulation of glycosaminoglycan. A previous case report highlighted that 3 years of ERT with recombinant human ASB (galsulfase) was well tolerated and effective in two Japanese siblings with MPS VI who initiated ERT at 5...
December 2017: Molecular Genetics and Metabolism Reports
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