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https://www.readbyqxmd.com/read/29162195/assessing-the-interplay-between-multigenic-and-environmental-influences-on-adolescent-to-adult-pathways-of-antisocial-behaviors
#1
James J Li
The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools)...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29146139/how-to-prevent-renal-cachexia-a-clinical-randomized-pilot-study-testing-oral-supplemental-nutrition-in-hemodialysis-patients-with-and-without-human-immunodeficiency-virus-infection
#2
Michael Zilles, Christoph Betz, Oliver Jung, Stefan Gauer, Renate Hammerstingl, Astrid Wächtershäuser, Thomas J Vogl, Helmut Geiger, Aida Asbe-Vollkopf, Rainer U Pliquett
OBJECTIVE: End-stage renal disease associates with catabolism and sarcopenia. Hypothetically, peroral supplemental nutrition over 6 months prevents catabolism in hemodialysis patients. DESIGN: Prospective randomized pilot study (ClinicalTrials.gov Identifier: NCT00687050). SUBJECTS: Twenty-three hemodialysis patients (15 males and 7 females) with or without human immunodeficiency virus (HIV) infection of 2 ambulatory hemodialysis centers...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29129137/citation-metrics-of-excellence-in-sports-biomechanics-research
#3
Duane Knudson
This study extended research on key citation metrics of winners of two career scholar awards in sports biomechanics. Google Scholar (GS) was searched using Harzing's Publish or Perish software for the 13 most recent winners of the ISBS Geoffrey Dyson Award and the ASB Jim Hay Memorial Award. Returned records were corrected for author, and publications excluded for all but peer-reviewed journal articles, proceedings articles, chapters and books in English. These recent award winners had published about 150 publications that had been cited typically 4,082 and 6,648 times over a 26- and 28-year period before receiving these career awards for sports biomechanics research...
November 13, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/29120787/speciation-analysis-of-six-arsenic-species-in-marketed-shellfish-extraction-optimization-and-health-risk-assessment
#4
Yuyu Jia, Lin Wang, Li Ma, Zhaoguang Yang
A comparative study between microwave assisted and sonication methods was carried out to extract arsenic (As) species in shellfish samples using different extractants. Six As species including arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB) and arsenocholine (AsC) were simultaneously separated and determined by the HPLC-ICP-MS method. The microwave assisted method exhibited higher efficiency than sonication, especially using diluted HNO3 as extractant...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29107038/routine-urine-testing-at-the-spinal-cord-injury-annual-evaluation-leads-to-unnecessary-antibiotic-use-a-pilot-study-and-future-directions
#5
Felicia Skelton, Larissa Grigoryan, Sally Ann Holmes, Ivy Oiyee Poon, Barbara Trautner
OBJECTIVE: To measure the prevalence of ASB in persons with spinal cord injury (SCI) at the time of their annual examination, and examine the impact on urine testing during the annual examination on subsequent antibiotic use. DESIGN: retrospective cohort study SETTING: a major Veterans Health Administration SCI center PARTICIPANTS: Veterans with SCI seen for an outpatient annual evaluation in 2012 or 2013 (n=393) MAIN OUTCOME MEASURE: antibiotic use for bacteriuria within seven days of the annual evaluation encounter RESULTS: Of the 327 clinic visits that met inclusion criteria, of which 249 had a urine culture performed...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29100693/arsenic-biokinetics-and-bioavailability-in-deposit-feeding-clams-and-polychaetes
#6
Wei Zhang, Wen-Xiong Wang
In the present study, the arsenic (As) biokinetics and bioavailability in two deposit-feeding invertebrates (clams Gafrarium tumidum and polychaetes Nereis succinea) were quantified. Radiotracer techniques were applied to measure the dissolved uptake rate, dietary assimilation efficiency and efflux of As by the clams and polychaetes. Simultaneously, arsenic species analysis was conducted to examine the As biotransformation following dietary uptake. The radiotracer results showed that the uptake rate constant and efflux rate constant were 0...
October 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29040879/influence-of-sexual-behavior-of-dorper-rams-treated-with-glutamate-and-or-testosterone-on-reproductive-performance-of-anovulatory-ewes
#7
Guadalupe Calderón-Leyva, Cesar A Meza-Herrera, Rafael Rodriguez-Martinez, Oscar Angel-García, Raymundo Rivas-Muñoz, Juan V Delgado-Bermejo, Francisco G Véliz-Deras
The aim of this study was to determine if exogenous administration of glutamate and (or) testosterone to male rams during the season of reproductive arrest is able to re-activate male sexual behavior and, later on, to promote through the male effect, both sexual and reproductive competence of anovulatory nulliparous ewes. Therefore, an experiment was performed under long-day photoperiods (spring; photo-reproductive arrest, 26°N). Dorper rams were randomly divided into four homogeneous experimental groups (n = 5 males each) regarding live weight (LW), body condition score (BCS), scrotal circumference (SC) and odor intensity (OI)...
October 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/29029779/redefining-the-abdominal-seatbelt-sign-enhanced-ct-imaging-metrics-improve-injury-prediction
#8
Michael C Johnson, Brian J Eastridge
INTRODUCTION: The abdominal seatbelt sign (ASBS) has an established association with abdominal injury, yet its definition remains ill-defined. We hypothesize specific imaging characteristics associated with the ASBS such as location above the pelvic brim and depth of abdominal wall contusion would better predict underlying injury and need for operative intervention. METHODS: We performed a retrospective chart review of subjects suffering from restrained motor vehicle collisions (MVC) evaluated at a level one trauma facility from 2010 to 2015...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28983456/enzyme-replacement-therapy-attenuates-disease-progression-in-two-japanese-siblings-with-mucopolysaccharidosis-type-vi-10-year-follow-up
#9
Mahoko Furujo, Motomichi Kosuga, Torayuki Okuyama
Early initiation of enzyme replacement therapy (ERT) has demonstrated clinical benefit in patients with mucopolysaccharidosis type VI (MPS VI), a progressive, multisystem autosomal recessive lysosomal disorder caused by N-acetylgalactosamine-4-sulphatase (ASB) deficiency and the consequent accumulation of glycosaminoglycan. A previous case report highlighted that 3 years of ERT with recombinant human ASB (galsulfase) was well tolerated and effective in two Japanese siblings with MPS VI who initiated ERT at 5...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28979981/genome-wide-association-studies-of-a-broad-spectrum-of-antisocial-behavior
#10
Jorim J Tielbeek, Ada Johansson, Tinca J C Polderman, Marja-Riitta Rautiainen, Philip Jansen, Michelle Taylor, Xiaoran Tong, Qing Lu, Alexandra S Burt, Henning Tiemeier, Essi Viding, Robert Plomin, Nicholas G Martin, Andrew C Heath, Pamela A F Madden, Grant Montgomery, Kevin M Beaver, Irwin Waldman, Joel Gelernter, Henry R Kranzler, Lindsay A Farrer, John R B Perry, Marcus Munafò, Devon LoParo, Tiina Paunio, Jari Tiihonen, Sabine E Mous, Irene Pappa, Christiaan de Leeuw, Kyoko Watanabe, Anke R Hammerschlag, Jessica E Salvatore, Fazil Aliev, Tim B Bigdeli, Danielle Dick, Stephen V Faraone, Arne Popma, Sarah E Medland, Danielle Posthuma
Importance: Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified. Objectives: To estimate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortium...
October 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28942808/effects-of-excessive-alcohol-use-on-antisocial%C3%A2-behavior-across-adolescence-and%C3%A2-early-adulthood
#11
Gemma Hammerton, Liam Mahedy, Joseph Murray, Barbara Maughan, Alexis C Edwards, Kenneth S Kendler, Matthew Hickman, Jon Heron
OBJECTIVE: Antisocial behavior (ASB) decreases with age in most of the population; however, excessive alcohol use can inhibit the desistance process. This study investigated whether excessive early drinking might slow a young person's overall pattern of crime desistance compared with that of others ("between-person effects") and whether short-term increases in alcohol consumption might result in short-term increases in ASB ("within-person effects"). METHOD: Frequency of ASB and typical alcohol consumption were assessed repeatedly in young people 15 to 21 years old in a population-based birth cohort (Avon Longitudinal Study of Parents and Children)...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28933357/risk-of-asymptomatic-bacteriuria-among-people-with-sickle-cell-disease-in-accra-ghana
#12
Eric S Donkor, Jonathan A Osei, Isaac Anim-Baidoo, Samuel Darkwah
Asymptomatic bacteriuria (ASB) is benign except in certain medical conditions such as pregnancy and immunosuppression. In Ghana, there are hardly any studies on urinary infections among sickle cell disease (SCD) patients, and the few studies carried out in Africa focused on pediatric SCD populations. The current study aimed to investigate the risk of ASB among SCD patients at a tertiary hospital in Ghana. This was a cross-sectional study involving 110 SCD patients and 110 age and sex matched healthy controls...
February 15, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28900020/petrobactin-is-exported-from-bacillus-anthracis-by-the-rnd-type-exporter-apex
#13
A K Hagan, A Tripathi, D Berger, D H Sherman, P C Hanna
Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobactin, an iron-scavenging small molecule known as a siderophore. Petrobactin biosynthesis is mediated by asb gene products, and import of the iron-bound (holo)-siderophore into the bacterium has been well studied...
September 12, 2017: MBio
https://www.readbyqxmd.com/read/28874796/controlled-self-organization-of-polymer-nanopatterns-over-large-areas
#14
Ilknur Hatice Eryilmaz, John Mohanraj, Simone Dal Zilio, Alessandro Fraleoni-Morgera
Self-assembly methods allow to obtain ordered patterns on surfaces with exquisite precision, but often lack in effectiveness over large areas. Here we report on the realization of hierarchically ordered polymethylmethacrylate (PMMA) nanofibres and nanodots over large areas from solution via a fast, easy and low-cost method named ASB-SANS, based on a ternary solution that is cast on the substrate. Simple changes to the ternary solution composition allow to control the transition from nanofibres to nanodots, via a wide range of intermediate topologies...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870857/molecular-characterization-and-expression-analysis-of-interferon-gamma-in-black-seabream-acanthopagrus-schlegelii
#15
Yangxi Xiang, Wei Liu, Peng Jia, Yunlong Li, Yilin Jin, Limin Chen, Jing Zhang, Kuntong Jia, Meisheng Yi
Interferon gamma (IFN-γ) is a major component in immunological signaling and plays a key role in resisting viral infection. In this study, we identified and characterized an IFN-γ gene (AsIFN-γ) in the marine fish black seabream (Acanthopagrus schlegelii). We cloned AsIFN-γ genomic sequence, which comprises four exons, three introns and an upstream promoter including several conserved regulatory elements. The complete cDNA of AsIFN-γ was 816 bp in length and encoded a putative 194 amino acids (aa) protein with a 22 aa signal peptide, six α-helices and one nuclear localization signal (NLS)...
September 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28836235/biophysical-approaches-in-the-study-of-biomembrane-solubilization-quantitative-assessment-and-the-role-of-lateral-inhomogeneity
#16
REVIEW
Karin A Riske, Cleyton C Domingues, Bruna R Casadei, Bruno Mattei, Amanda C Caritá, Rafael B Lira, Paulo S C Preté, Eneida de Paula
Detergents are amphiphilic molecules widely used to solubilize biological membranes and/or extract their components. Nevertheless, because of the complex composition of biomembranes, their solubilization by detergents has not been systematically studied. In this review, we address the solubilization of erythrocytes, which provide a relatively simple, robust and easy to handle biomembrane, and of biomimetic models, to stress the role of the lipid composition on the solubilization process. First, results of a systematic study on the solubilization of human erythrocyte membranes by different series of non-ionic (Triton, CxEy, Brij, Renex, Tween), anionic (bile salts) and zwitterionic (ASB, CHAPS) detergents are shown...
October 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28789721/sociodemographic-lifestyle-and-behavioural-factors-associated-with-consumption-of-sweetened-beverages-among-adults-in-cambridgeshire-uk-the-fenland-study
#17
Peter Barrett, Fumiaki Imamura, Søren Brage, Simon J Griffin, Nicholas J Wareham, Nita G Forouhi
OBJECTIVE: We aimed to identify sociodemographic, lifestyle and behavioural determinants of consumption of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) among adults in Cambridgeshire, UK. DESIGN: Cross-sectional data were obtained from a cohort of 9991 adults born between 1950 and 1975. An FFQ was used to assess consumption of beverages and other dietary factors. Multivariable logistic regression was used to examine potential determinants of consuming SSB and ASB (≥1 serving/d)...
August 9, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28772151/concentrations-of-urinary-arsenic-species-in-relation-to-rice-and-seafood-consumption-among-children-living-in-spain
#18
Antonio J Signes-Pastor, Jesus Vioque, Eva M Navarrete-Muñoz, Manus Carey, Manoli García de la Hera, Jordi Sunyer, Maribel Casas, Isolina Riaño-Galán, Adonina Tardón, Sabrina Llop, Rubén Amorós, Pilar Amiano, José R Bilbao, Margaret R Karagas, Andrew A Meharg
Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28763649/biomarkers-of-arsenic-exposure-in-arsenic-affected-areas-of-the-hetao-basin-inner-mongolia
#19
Ting Liu, Huaming Guo, Wei Xiu, Chao Wei, Xiaomeng Li, Zhen Di, Wei Song
Seventy saliva samples, seventy urine samples, seventy nail samples, seventy hair samples, eight drinking water samples and ninety-three crop samples were collected from four villages of the Hetao Basin in Inner Mongolia to determine arsenic (As) exposure biomarkers and evaluate relationship between As uptake and human health risk. Trivalent As (As(III)), pentavalent As (As(V)), dimethylarsinic acid (DMA), arsenobetaine (AsB) and monomethylarsonic acid (MMA) were found in all urine samples. Only As(III) and As(V) were detected in saliva samples...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28757678/microrna-expression-in-malignant-pleural-mesothelioma-and-asbestosis-a-pilot-study
#20
Paola Mozzoni, Luca Ampollini, Matteo Goldoni, Rossella Alinovi, Marcello Tiseo, Letizia Gnetti, Paolo Carbognani, Michele Rusca, Antonio Mutti, Antonio Percesepe, Massimo Corradi
BACKGROUND: The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying the disease development and progression. AIMS: To identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients. METHODS: miRNA-16, miRNA-17, miRNA-126, and miRNA-486 were quantified in plasma and formalin-fixed paraffin-embedded samples to evaluate their diagnostic and prognostic roles compared to patients with other noncancerous pulmonary diseases (controls)...
2017: Disease Markers
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