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vamsidhar velcheti

Sai-Hong Ignatius Ou, Alexa B Schrock, Eduard V Bocharov, Samuel J Klempner, Carolina Kawamura Haddad, Gary Steinecker, Melissa Johnson, Barbara J Gitlitz, Jon Chung, Paulo V Campregher, Jeffrey S Ross, Philip J Stephens, Vincent A Miller, James H Suh, Siraj M Ali, Vamsidhar Velcheti
INTRODUCTION: HER2 transmembrane domain (TMD) mutations (HER2(V659E), HER2(G660D)) have previously been identified in lung adenocarcinomas, but their frequency and clinical significance is unknown. METHODS: We prospectively analyzed 8,551 consecutive lung adenocarcinomas using hybrid-capture based comprehensive genomic profiling (CGP) at the request of the individual treating physicians for the purpose of making therapy decisions. RESULTS: We identified 15 cases (0...
November 26, 2016: Journal of Thoracic Oncology
Charles D Sturgis, Dana Ataya, Benjamin C Calhoun, Vamsidhar Velcheti, Sanjay Mukhopadhyay
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
Sameep Sehgal, Vamsidhar Velcheti, Sanjay Mukhopadhyay, James K Stoller
A 58-year-old woman with stage 4 adenocarcinoma of the lung being treated with pembrolizumab developed dyspnea, non-productive cough, and a right middle lobe infiltrate. Complete resolution of the infiltrate with cessation of pembrolizumab, initiation of prednisone and no antibiotic therapy suggested drug-associated lung toxicity as the cause. While the programmed death-1 (PD-1) inhibitors -pembrolizumab and nivolumab - have been implicated as a cause of diffuse or multifocal pulmonary infiltrates, the current case represents, to our knowledge, the first instance of a unilobar, focal infiltrate associated with their use...
2016: Respiratory Medicine Case Reports
Min Huang, Yanyan Lou, James Pellissier, Thomas Burke, Frank Xiaoqing Liu, Ruifeng Xu, Vamsidhar Velcheti
OBJECTIVES: This analysis aimed to evaluate the cost-effectiveness of pembrolizumab compared with docetaxel in patients with previously treated advanced non-squamous cell lung cancer (NSCLC) with PD-L1 positive tumors (total proportion score [TPS] ≥ 50%). The analysis was conducted from a US third-party payer perspective. METHODS: A partitioned-survival model was developed using data from patients from the KEYNOTE 010 clinical trial. The model used Kaplan-Meier (KM) estimates of progression-free survival (PFS) and overall survival (OS) from the trial for patients treated with either pembrolizumab 2 mg/kg or docetaxel 75 mg/m(2) with extrapolation based on fitted parametric functions and long-term registry data...
October 3, 2016: Journal of Medical Economics
Leonard Calabrese, Vamsidhar Velcheti
No abstract text is available yet for this article.
August 26, 2016: Annals of the Rheumatic Diseases
Kurt A Schalper, Daniel Carvajal-Hausdorf, Joseph McLaughlin, Mehmet Altan, Vamsidhar Velcheti, Patricia Gaule, Miguel F Sanmamed, Lieping Chen, Roy S Herbst, David L Rimm
PURPOSE: To determine the expression level, associations and biological role of PD-L1, IDO-1 and B7-H4 in non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: Using multiplexed quantitative immunofluorescence (QIF), we measured the levels of PD-L1, IDO-1, B7-H4 and different tumor infiltrating lymphoycte (TIL) subsets in 552 stages I-IV lung carcinomas from 2 independent populations. Associations between the marker levels, TILs and major clinico-pathological variables were determined...
July 20, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Vamsidhar Velcheti, Kurt Schalper
Recent success of immunotherapy strategies such as immune checkpoint blockade in several malignancies has established the role of immunotherapy in the treatment of cancer. Cancers use multiple mechanisms to co-opt the host-tumor immune interactions, leading to immune evasion. Our understanding of the host-tumor interactions has evolved over the past few years and led to various promising new therapeutic strategies. This article will focus on the basic principles of immunotherapy, novel pathways/agents, and combinatorial immunotherapies...
2016: American Society of Clinical Oncology Educational Book
Lindsey Martin Goodman, Machelle B Moeller, Abdel-Ghani Azzouqa, Amy E Guthrie, Carole K Dalby, Marc A Earl, Connie Cheng, Nathan A Pennell, Marc Shapiro, Vamsidhar Velcheti, James P Stevenson
PURPOSE: Routine prophylactic pegylated granulocyte colony-stimulating factor (pGCSF) administration for patients receiving chemotherapy regimens associated with low risk (< 10%) for neutropenic fever (LRNF) is not recommended. Inappropriate use of pGCSF increases patient morbidity and health care costs. METHODS: A multidisciplinary team reviewed the charts of patients with non-small-cell lung cancer (NSCLC) at the Taussig Cancer Institute in whom a new chemotherapy regimen was initiated from April through November 2013...
January 2016: Journal of Oncology Practice
Todd Hembrough, Wei-Li Liao, Christopher P Hartley, Patrick C Ma, Vamsidhar Velcheti, Christopher Lanigan, Sheeno Thyparambil, Eunkyung An, Manish Monga, David Krizman, Jon Burrows, Laura J Tafe
BACKGROUND: Crizotinib has antitumor activity in ALK (anaplastic lymphoma receptor tyrosine kinase)-rearranged non-small cell lung cancer (NSCLC). The current diagnostic test for ALK rearrangement is breakapart fluorescence in situ hybridization (FISH), but FISH has low throughput and is not always reflective of protein concentrations. The emergence of multiple clinically relevant biomarkers in NSCLC necessitates efficient testing of scarce tissue samples. We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue...
January 2016: Clinical Chemistry
Joseph McLaughlin, Gang Han, Kurt A Schalper, Daniel Carvajal-Hausdorf, Vasiliki Pelekanou, Jamaal Rehman, Vamsidhar Velcheti, Roy Herbst, Patricia LoRusso, David L Rimm
IMPORTANCE: Early-phase trials with monoclonal antibodies targeting PD-1 (programmed cell death protein 1) and PD-L1 (programmed cell death 1 ligand 1) have demonstrated durable clinical responses in patients with non-small-cell lung cancer (NSCLC). However, current assays for the prognostic and/or predictive role of tumor PD-L1 expression are not standardized with respect to either quantity or distribution of expression. OBJECTIVE: To demonstrate PD-L1 protein distribution in NSCLC tumors using both conventional immunohistochemistry (IHC) and quantitative immunofluorescence (QIF) and compare results obtained using 2 different PD-L1 antibodies...
January 2016: JAMA Oncology
Maria Vassilakopoulou, Margaritis Avgeris, Vamsidhar Velcheti, Vassiliki Kotoula, Theodore Rampias, Kyriakos Chatzopoulos, Christos Perisanidis, Christos K Kontos, Aris I Giotakis, Andreas Scorilas, David Rimm, Clarence Sasaki, George Fountzilas, Amanda Psyrri
PURPOSE: Programmed death-ligand 1 (PD-L1; also known as CD274 or B7-H1) expression represents a mechanism of immune escape for cancer. Our purpose was to characterize tumor PD-L1 expression and associated T-cell infiltration in primary laryngeal squamous cell carcinomas (SCC). EXPERIMENTAL DESIGN: A well-annotated cohort of 260 operable primary laryngeal SCCs [formalin-fixed paraffin-embedded (FFPE) specimens] was morphologically characterized for stromal tumor-infiltrating lymphocytes (TIL), on hematoxylin/eosin-stained whole sections and for PD-L1 mRNA expression by qRT-PCR in FFPE specimens...
February 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Vyshak Alva Venur, Gloria Zhang, Carol Farver, Sanjay Mukhopadhyay, Daniel P Raymond, Vamsidhar Velcheti
We report a case of granular cell tumor (GCT) of the lung with coexistent invasive adenocarcinoma. GCTs are rare tumors and often benign and amenable to local bronchoscopic excision. However, occasionally they are more aggressive and locally infiltrative requiring definitive surgical resection. Our patient had a central and infiltrative GCT, in addition a very small (6 mm) peripheral nodule in the same lobe as the GCT, which after careful examination of the surgical specimen during grossing was found to be an invasive adenocarcinoma...
August 2014: Translational Lung Cancer Research
Kurt A Schalper, Jason Brown, Daniel Carvajal-Hausdorf, Joseph McLaughlin, Vamsidhar Velcheti, Konstantinos N Syrigos, Roy S Herbst, David L Rimm
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are usually measured using subjective methods. Studies suggest that TIL subtypes have independent roles in cancer and that they could support the use of novel immunostimulatory therapies. We simultaneously measured TIL subtypes in non-small cell lung cancer (NSCLC) samples using objective methods and determined their relationship with clinico-pathologic characteristics and survival. METHODS: Using multiplexed quantitative fluorescence (QIF), we measured the levels of CD3, CD8, and CD20 in 552 NSCLC from two independent collections represented in tissue microarrays (YTMA79, n = 202 and YTMA140, n = 350)...
March 2015: Journal of the National Cancer Institute
Sanjay Mukhopadhyay, Nathan A Pennell, Siraj M Ali, Jeffrey S Ross, Patrick C Ma, Vamsidhar Velcheti
Oncogenic rearrangements of the RET gene have recently been described in 1% to 2% of lung adenocarcinomas. We report five cases of RET-rearranged lung adenocarcinoma with an unusual constellation of clinical and histologic features that has not previously been described in tumors with this genomic alteration. The age at diagnosis of the five patients (4F, 1M) ranged from 44 to 77 years. All were never-smokers. Radiologically, four tumors showed lymphangitic spread within the lungs at presentation; three of these had multiple bilateral lung nodules...
November 2014: Journal of Thoracic Oncology
Tanmay Panchabhai, Debabrata Bandyopadhyay, Siva Raja, Sudhish Murthy, Vamsidhar Velcheti, Sanjay Mukhopadhyay, Joseph Cicenia, Sonali Sethi
Bronchology/Interventional Procedures Cases IISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Monday, October 27, 2014 at 11:00 AM - 12:00 PMINTRODUCTION: Inflammatory Myofibroblastic tumors (IMT) were previously included in the loose term "Inflammatory Pseudotumor." However, the rarity of these tumors makes diagnosis and management fairly challenging. We present an interesting presentation of an endobronchial presentation of IMT.CASE PRESENTATION: An 18-year-old non-smoking female presented with cough and intermittent hemoptysis over a few weeks...
October 1, 2014: Chest
Kurt A Schalper, Vamsidhar Velcheti, Daniel Carvajal, Hallie Wimberly, Jason Brown, Lajos Pusztai, David L Rimm
PURPOSE: Blockade of the PD-1/PD-L1 axis emerged as a promising new therapeutic option for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and melanomas. Tumor PD-L1 protein expression may predict response to drugs targeting this pathway. Measurement of PD-L1 protein is limited by the lack of standardized immunohistochemical methods and variable performance of antibodies. Our goal was to correlate PD-L1 mRNA expression with clinical variables in primary breast carcinomas...
May 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Vamsidhar Velcheti, Kurt A Schalper, Daniel E Carvajal, Valsamo K Anagnostou, Konstantinos N Syrigos, Mario Sznol, Roy S Herbst, Scott N Gettinger, Lieping Chen, David L Rimm
Recent strategies targeting the interaction of the programmed cell death ligand-1 (PD-L1, B7-H1, CD274) with its receptor, PD-1, resulted in promising activity in early phase clinical trials. In this study, we used various antibodies and in situ mRNA hybridization to measure PD-L1 in non-small cell lung cancer (NSCLC) using a quantitative fluorescence (QIF) approach to determine the frequency of expression and prognostic value in two independent populations. A control tissue microarray (TMA) was constructed using PD-L1-transfected cells, normal human placenta and known PD-L1-positive NSCLC cases...
January 2014: Laboratory Investigation; a Journal of Technical Methods and Pathology
Vamsidhar Velcheti, David L Rimm, Kurt A Schalper
Programmed death-1 (PD-1) is a coinhibitory inducible receptor present on T-cells and macrophages. Tumor cells with increased programmed death ligand-1 (PD-L1) are believed to escape immunity through activation of PD-1/PD-L1 pathway and suppression of effector-immune responses. Recent strategies targeting the PD-1/PD-L1 axis have shown promising results in patients with several tumors types, including lung carcinomas. Preliminary data suggest that PD-L1 protein expression might have predictive response to such therapies...
June 2013: Journal of Thoracic Oncology
Vamsidhar Velcheti, Kurt Schalper, Xiaopan Yao, Huan Cheng, Mehmet Kocoglu, Kavita Dhodapkar, Yanhong Deng, Scott Gettinger, David L Rimm
BACKGROUND: SOX2 is an embryonic developmental transcription factor, which is important in the development of the respiratory tract. SOX2 overexpression is associated with aggressive disease in several tumor types. However, SOX2 overexpression and gene amplification associates with favorable outcome in lung squamous cell carcinomas (SCC) and dissimilar results have been reported in lung adenocarcinomas (ADC). The aim of the present study was to evaluate SOX2 expression in NSCLC and determine the relationship with clinico-pathological variables and outcome...
2013: PloS One
Vamsidhar Velcheti, Satish Karnik, Stephen F Bardot, Om Prakash
In the United States, prostate cancer is the second most common cause of cancer-related deaths in men. While the importance of androgens and androgen receptors (ARs) in primary prostate cancer is well established, the role of ARs in prostate cancers that emerge despite androgen ablation therapies remains poorly understood. The aim of this article is to illustrate the fundamental biology of prostate cancer. We focus mainly on the AR because of its critical role in the progression and metastatic spread of prostate cancer...
2008: Ochsner Journal
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