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https://www.readbyqxmd.com/read/28704413/association-of-insulin-resistance-with-near-peak-bone-mass-in-the-femur-and-lumbar-spine-of-korean-adults-aged-25-35-the-korean-national-health-and-nutrition-examination-survey-2008-2010
#1
Min Soo Choo, Se Rin Choi, Jun Hyun Han, Seong Ho Lee, Young Suk Shim
OBJECTIVE: This study aimed to evaluate the relationship between insulin resistance and the bone mineral density (BMD) of femur and lumbar spine in Korean adults who are expected to exhibit near peak bone mass. METHODS: Data from the Korean National Health and Nutrition Examination Survey 2008-2010 were analyzed. A total of 2,750 participants aged 25-35 years were included. Insulin resistance was assessed using a homeostatic model assessment of insulin resistance (HOMA-IR) and serum fasting insulin...
2017: PloS One
https://www.readbyqxmd.com/read/28413494/preoperative-qct-assessment-of-femoral-head-for-assessment-of-femoral-head-bone-loss
#2
Chen Yi, Manyi Wang, Jie Wei, Jun Wang, Ling Wang, Xiaoguang Cheng
We quantified differences in trabecular volumetric bone mineral density (BMD) of the femoral head between patients with proximal femoral fractures and healthy subjects in the control group by using quantitative computed tomography (QCT) with the purpose of providing guidance for the choice of head screw in the intramedullary nail fixation. Participants suffering from intertrochanteric fractures (n=536 patients) were recruited. In addition, 497 fracture-free, age-matched cases were considered as the control group...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28053824/low-normal-tsh-levels-are-associated-with-impaired-bmd-and-hip-geometry-in-the-elderly
#3
Su Jin Lee, Kyoung Min Kim, Eun Young Lee, Mi Kyung Song, Dae Ryong Kang, Hyeon Chang Kim, Yoosik Youm, Young Mi Yun, Hyun-Young Park, Chang Oh Kim, Yumie Rhee
Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28034591/women-with-polycystic-ovary-syndrome-have-comparable-hip-bone-geometry-to-age-matched-control-women
#4
Laura E McBreairty, Gordon A Zello, Julianne J Gordon, Shani B Serrao, Roger A Pierson, Donna R Chizen, Philip D Chilibeck
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28031507/combined-use-of-ibandronate-and-eldecalcitol-in-postmenopausal-japanese-women-with-osteoporosis
#5
Junichi Takada, Hiroshi Wada, Kousuke Iba, Kouichi Sasaki, Takayuki Dohke, Kumiko Kanaya, Takashi Yoshizaki, Toshihiko Yamashita
PURPOSE: To evaluate the effect of combined use of ibandronate and eldecalcitol for 6 to 12 months on bone mineral density (BMD) and bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis. METHODS: BMD and bone strength of the proximal femur were evaluated in 78 postmenopausal women (mean age, 73.6 years) who underwent treatment for osteoporosis with combined use of ibandronate and eldecalcitol for at least 6 months. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry (DXA) at baseline and every 6 months thereafter...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27776156/reconsideration-of-the-effects-of-age-on-proximal-femur-structure-implications-for-joint-replacement-and-hip-fracture
#6
B C C Khoo, J K Brown, R L Prince
OBJECTIVES: In recent years quantitative computed tomography (QCT) has allowed precise non-invasive, three dimensional, in vivo measurement of hip structure in large numbers of individuals. The effects of ageing on proximal femur structure are reported and implications for the prevention of hip prosthesis loosening and hip fracture considered. DESIGN, SETTING AND PARTICIPANTS: An observational cross-sectional study of proximal femur QCT in 719 unselected female European descent aged 20 to 89 years recruited from US and Australian populations...
2016: PloS One
https://www.readbyqxmd.com/read/27157300/adherence-to-the-mediterranean-diet-is-associated-with-a-higher-bmd-in-middle-aged-and-elderly-chinese
#7
Geng-Dong Chen, Xiao-Wei Dong, Ying-Ying Zhu, Hui-Yuan Tian, Juan He, Yu-Ming Chen
Previous studies showed that better adherence to the Mediterranean diet (MD) is associated with lower risk of chronic diseases, but limited data are available on bone health. We investigated the association of the MD with bone mineral density (BMD) in Chinese adults. We included 2371 participants aged 40-75 years in this community-based cross-sectional study. Dietary information was assessed at baseline and a 3-year follow-up. Alternate Mediterranean diet (aMed) scores were calculated. BMD was determined at the second survey...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26966046/intramedullary-nailing-has-sufficient-durability-for-metastatic-femoral-fractures
#8
Takaaki Tanaka, Jungo Imanishi, Chris Charoenlap, Peter F M Choong
BACKGROUND: Surgical treatment options of femoral metastases include intramedullary nailing (IMN) and endoprosthetic reconstruction (EPR). Previous studies have demonstrated functional and oncological advantages of EPR over IMN. The purpose of this study was to (1) report the durability of IMN and (2) establish the indication of IMN for femoral metastases. METHODS: In 2003-2013, among 186 surgically treated femoral metastasis cases, we retrospectively reviewed 80 consecutive IMN cases in 75 patients, including 14 pathological and 66 impending fractures...
March 10, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26805871/associations-of-age-bmi-and-years-of-menstruation-with-proximal-femur-strength-in-chinese-postmenopausal-women-a-cross-sectional-study
#9
Huili Kang, Yu-Ming Chen, Guiyuan Han, Hua Huang, Wei-Qing Chen, Xidan Wang, Ying-Ying Zhu, Su-Mei Xiao
This study aimed to elucidate the associations of age, BMI, and years of menstruation with proximal femur strength in Chinese postmenopausal women, which may improve the prediction of hip fracture risk. A cross-sectional study was conducted in 1322 Chinese postmenopausal women recruited from communities. DXA images were used to generate bone mineral density (BMD) and geometric parameters, including cross-sectional area (CSA), outer diameter (OD), cortical thickness (CT), section modulus (SM), buckling ratio (BR) at the narrow neck (NN), intertrochanter (IT), and femoral shaft (FS)...
January 23, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26507315/association-of-dietary-and-serum-vitamin-e-with-bone-mineral-density-in-middle-aged-and-elderly-chinese-adults-a-cross-sectional-study
#10
Wen-qi Shi, Jun Liu, Yi Cao, Ying-ying Zhu, Ke Guan, Yu-ming Chen
Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40-75 years from Guangzhou, People's Republic of China. General and dietary intake information were collected using structured questionnaire interviews. The serum α-tocopherol (TF) level was quantified by reversed-phase HPLC...
January 14, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26282230/evaluation-of-a-simplified-hip-structure-analysis-method-for-the-prediction-of-incident-hip-fracture-events
#11
B C C Khoo, J R Lewis, K Brown, R L Prince
UNLABELLED: Many attempts have been made to improve the predictive ability of areal bone mineral density (aBMD) which integrates bone mass and area. The addition of an extra variable derived from the hip dual-energy X-ray (DXA) image TR_σ, which describes distribution of mass within the scanned area of the trochanter, improved prediction of 15-year hip fracture probability in elderly women. INTRODUCTION: Two-dimensional DXA imaging of the proximal femur to produce an aBMD is a clinically useful predictor of future fracture risk...
January 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26056023/assessment-of-osteoporosis-using-pelvic-diagnostic-computed-tomography
#12
Yee-Suk Kim, Seunghun Lee, Yoon-Kyoung Sung, Bong-Gun Lee
The purpose of the present study is to determine if a correlation exists between bone mineral density (BMD) obtained from dual energy X-ray absorptiometry (DXA) and Hounsfield unit (HU) from pelvic diagnostic computed tomography (dCT), and to evaluate whether HU could be used to identify osteoporosis. Seventy-nine patients were included in this study. HU values were measured in three different sections: the head-neck junction of the femur, the middle portion of the femoral neck, and the intertrochanter of the femur (IT)...
July 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/25813959/study-of-hip-fracture-risk-by-dxa-based-patient-specific-finite-element-model
#13
Zannatul Ferdous, Yunhua Luo
A number of factors may have effects on hip fracture, for example, bone mineral density (BMD), body weight and height, femur length, femoral neck length, etc. It is not clear which factor(s) has the dominant effect on hip fracture. Therefore, the factors were investigated by a previously developed DXA (dual energy X-ray absorptiometry) based finite element model. The finite element model is patient-specific, as all information required in constructing the model was extracted from the patient's hip DXA image...
2015: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/25436066/the-relationship-between-osteoarthritis-of-the-knee-and-bone-mineral-density-of-proximal-femur-a-cross-sectional-study-from-a-korean-population-in-women
#14
Gun-Il Im, Oh-Jin Kwon, Chang Hee Kim
BACKGROUND: The relationship between osteoarthritis (OA) and osteoporosis (OP) is complicated and it may differ according to the site or stage of disease. The purpose of this cross-sectional study is to examine the relationship between the severity of radiological knee OA and the degree of OP in the ipsilateral proximal femur as denoted by bone mineral density (BMD) in a Korean population, especially among women. METHODS: One hundred ninety-five female patients who had knee pain and radiological knee OA were investigated with respect to the relationship of knee OA severity with BMD...
December 2014: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/24948038/relationship-between-leptin-and-adiponectin-concentrations-in-plasma-and-femoral-and-spinal-bone-mineral-density-in-spinal-cord-injured-individuals
#15
Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Farzad Shidfar, Mohammad Reza Vafa, Seyed-Hassan Emami Razavi, Bagher Larijani, Ramin Heshmat
BACKGROUND CONTEXT: Previously, the associations between leptin and adiponectin levels with bone mineral density (BMD) have been reported in different populations, and occasionally, controversial results have been demonstrated. Until now, these relationships in spinal cord-injured individuals have not yet been described. PURPOSE: We tried to investigate the correlation between leptin and adiponectin concentrations in plasma and BMD in Iranian patients with spinal cord injury (SCI)...
January 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/24898537/odanacatib-treatment-affects-trabecular-and-cortical-bone-in-the-femur-of-postmenopausal-women-results-of-a-two-year-placebo-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Klaus Engelke, Thomas Fuerst, Bernard Dardzinski, John Kornak, Shabana Ather, Harry K Genant, Anne de Papp
Odanacatib, a selective cathepsin K inhibitor, increases areal bone mineral density (aBMD) at the spine and hip of postmenopausal women. To gain additional insight into the effects on trabecular and cortical bone, we analyzed quantitative computed tomography (QCT) data of postmenopausal women treated with odanacatib using Medical Image Analysis Framework (MIAF; Institute of Medical Physics, University of Erlangen, Erlangen, Germany). This international, randomized, double-blind, placebo-controlled, 2-year, phase 3 trial enrolled 214 postmenopausal women (mean age 64 years) with low aBMD...
January 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/24038152/the-effect-of-the-cathepsin-k-inhibitor-ono-5334-on-trabecular-and-cortical-bone-in-postmenopausal-osteoporosis-the-ocean-study
#17
RANDOMIZED CONTROLLED TRIAL
Klaus Engelke, Shinichi Nagase, Thomas Fuerst, Maria Small, Tomohiro Kuwayama, Stephen Deacon, Richard Eastell, Harry K Genant
ONO-5334 (Ono Pharmaceutical Co., Ltd., Osaka, Japan) inhibits cathepsin K and has been shown to increase areal bone mineral density (BMD) at the hip and spine in postmenopausal osteoporosis. Quantitative computed tomography (QCT) allows the study of the cortical and trabecular bone separately and provides structural information such as cortical thickness. We investigated the impact of 2 years of cathepsin K inhibition on these different bone compartments with ONO-5334. The clinical study was a randomized, double-blind, placebo, and active controlled parallel group study conducted in 13 centers in six European countries...
March 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/24002345/adolescent-physical-activity-and-bone-strength-at-the-proximal-femur-in-adulthood
#18
Stefan A Jackowski, Saija A Kontulainen, David M L Cooper, Joel L Lanovaz, Thomas J Beck, Adam D G Baxter-Jones
INTRODUCTION: Physical activity (PA) enhances bone structural strength at the proximal femur in adolescence, but whether these benefits are maintained into early adulthood remains unknown. The purpose of this study was to investigate whether males and females, described as active, average, and inactive during adolescence, display differences in structural strength at the proximal femur in early adulthood (20-30 yr). METHODS: One hundred four participants (55 males and 49 females) from the Pediatric Bone Mineral Accrual Study (PBMAS) were categorized into adolescent PA groupings (inactive, average, and active) using the Physical Activity Questionnaire for Adolescents...
April 2014: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/23893256/operative-treatment-of-fai-open-hip-preservation-surgery
#19
Michael D Hellman, Andrew J Riff, Bryan D Haughom, Rikesh Patel, Michael D Stover, Shane J Nho
Femoroacetabular Impingement (FAI) is characterized by abnormal contact of the hip joint. Many etiologies cause this painful condition, which leads to early osteoarthritis. While hip arthroscopy has become the most prevalent way to surgically correct a hip, some presentations of FAI require open surgical hip preservation techniques to fully address the pathology at hand. Certain head neck deformities may require open surgical hip dislocation utilizing a trochanteric slide osteotomy. A retroverted acetabulum may require an open periacetabular osteotomy to gain anteversion and eliminate impingement in the hip joint...
September 2013: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/23744478/pelvis-width-associated-with-bone-mass-distribution-at-the-proximal-femur-in-children-10-11-years-old
#20
Graça Cardadeiro, Fátima Baptista, Kathleen F Janz, Luís A Rodrigues, Luís B Sardinha
Differences in skeletal geometry may generate different patterns of mechanical loading to bone. Impact and muscle loading during physical activity have been shown to influence skeletal geometry. The purpose of this study was to compare geometric measures of the pelvis and proximal femur (PF) of young children and to analyze the contribution and potential interaction of these geometric measures with physical activity on PF bone mass distribution. Participants were 149 girls and 145 boys, aged 10-11 years. Total body and left hip DXA scans were used to derive pelvic and PF geometric measures and PF bone mineral density (BMD) at the femoral neck (FN), trochanter (TR), and intertrochanter (IT)...
March 2014: Journal of Bone and Mineral Metabolism
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