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https://www.readbyqxmd.com/read/27776156/reconsideration-of-the-effects-of-age-on-proximal-femur-structure-implications-for-joint-replacement-and-hip-fracture
#1
B C C Khoo, J K Brown, R L Prince
OBJECTIVES: In recent years quantitative computed tomography (QCT) has allowed precise non-invasive, three dimensional, in vivo measurement of hip structure in large numbers of individuals. The effects of ageing on proximal femur structure are reported and implications for the prevention of hip prosthesis loosening and hip fracture considered. DESIGN, SETTING AND PARTICIPANTS: An observational cross-sectional study of proximal femur QCT in 719 unselected female European descent aged 20 to 89 years recruited from US and Australian populations...
2016: PloS One
https://www.readbyqxmd.com/read/27157300/adherence-to-the-mediterranean-diet-is-associated-with-a-higher-bmd-in-middle-aged-and-elderly-chinese
#2
Geng-Dong Chen, Xiao-Wei Dong, Ying-Ying Zhu, Hui-Yuan Tian, Juan He, Yu-Ming Chen
Previous studies showed that better adherence to the Mediterranean diet (MD) is associated with lower risk of chronic diseases, but limited data are available on bone health. We investigated the association of the MD with bone mineral density (BMD) in Chinese adults. We included 2371 participants aged 40-75 years in this community-based cross-sectional study. Dietary information was assessed at baseline and a 3-year follow-up. Alternate Mediterranean diet (aMed) scores were calculated. BMD was determined at the second survey...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26966046/intramedullary-nailing-has-sufficient-durability-for-metastatic-femoral-fractures
#3
Takaaki Tanaka, Jungo Imanishi, Chris Charoenlap, Peter F M Choong
BACKGROUND: Surgical treatment options of femoral metastases include intramedullary nailing (IMN) and endoprosthetic reconstruction (EPR). Previous studies have demonstrated functional and oncological advantages of EPR over IMN. The purpose of this study was to (1) report the durability of IMN and (2) establish the indication of IMN for femoral metastases. METHODS: In 2003-2013, among 186 surgically treated femoral metastasis cases, we retrospectively reviewed 80 consecutive IMN cases in 75 patients, including 14 pathological and 66 impending fractures...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26805871/associations-of-age-bmi-and-years-of-menstruation-with-proximal-femur-strength-in-chinese-postmenopausal-women-a-cross-sectional-study
#4
Huili Kang, Yu-Ming Chen, Guiyuan Han, Hua Huang, Wei-Qing Chen, Xidan Wang, Ying-Ying Zhu, Su-Mei Xiao
This study aimed to elucidate the associations of age, BMI, and years of menstruation with proximal femur strength in Chinese postmenopausal women, which may improve the prediction of hip fracture risk. A cross-sectional study was conducted in 1322 Chinese postmenopausal women recruited from communities. DXA images were used to generate bone mineral density (BMD) and geometric parameters, including cross-sectional area (CSA), outer diameter (OD), cortical thickness (CT), section modulus (SM), buckling ratio (BR) at the narrow neck (NN), intertrochanter (IT), and femoral shaft (FS)...
January 23, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26507315/association-of-dietary-and-serum-vitamin-e-with-bone-mineral-density-in-middle-aged-and-elderly-chinese-adults-a-cross-sectional-study
#5
Wen-qi Shi, Jun Liu, Yi Cao, Ying-ying Zhu, Ke Guan, Yu-ming Chen
Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40-75 years from Guangzhou, People's Republic of China. General and dietary intake information were collected using structured questionnaire interviews. The serum α-tocopherol (TF) level was quantified by reversed-phase HPLC...
January 14, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26282230/evaluation-of-a-simplified-hip-structure-analysis-method-for-the-prediction-of-incident-hip-fracture-events
#6
B C C Khoo, J R Lewis, K Brown, R L Prince
UNLABELLED: Many attempts have been made to improve the predictive ability of areal bone mineral density (aBMD) which integrates bone mass and area. The addition of an extra variable derived from the hip dual-energy X-ray (DXA) image TR_σ, which describes distribution of mass within the scanned area of the trochanter, improved prediction of 15-year hip fracture probability in elderly women. INTRODUCTION: Two-dimensional DXA imaging of the proximal femur to produce an aBMD is a clinically useful predictor of future fracture risk...
January 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26056023/assessment-of-osteoporosis-using-pelvic-diagnostic-computed-tomography
#7
Yee-Suk Kim, Seunghun Lee, Yoon-Kyoung Sung, Bong-Gun Lee
The purpose of the present study is to determine if a correlation exists between bone mineral density (BMD) obtained from dual energy X-ray absorptiometry (DXA) and Hounsfield unit (HU) from pelvic diagnostic computed tomography (dCT), and to evaluate whether HU could be used to identify osteoporosis. Seventy-nine patients were included in this study. HU values were measured in three different sections: the head-neck junction of the femur, the middle portion of the femoral neck, and the intertrochanter of the femur (IT)...
July 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/25813959/study-of-hip-fracture-risk-by-dxa-based-patient-specific-finite-element-model
#8
Zannatul Ferdous, Yunhua Luo
A number of factors may have effects on hip fracture, for example, bone mineral density (BMD), body weight and height, femur length, femoral neck length, etc. It is not clear which factor(s) has the dominant effect on hip fracture. Therefore, the factors were investigated by a previously developed DXA (dual energy X-ray absorptiometry) based finite element model. The finite element model is patient-specific, as all information required in constructing the model was extracted from the patient's hip DXA image...
2015: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/25436066/the-relationship-between-osteoarthritis-of-the-knee-and-bone-mineral-density-of-proximal-femur-a-cross-sectional-study-from-a-korean-population-in-women
#9
Gun-Il Im, Oh-Jin Kwon, Chang Hee Kim
BACKGROUND: The relationship between osteoarthritis (OA) and osteoporosis (OP) is complicated and it may differ according to the site or stage of disease. The purpose of this cross-sectional study is to examine the relationship between the severity of radiological knee OA and the degree of OP in the ipsilateral proximal femur as denoted by bone mineral density (BMD) in a Korean population, especially among women. METHODS: One hundred ninety-five female patients who had knee pain and radiological knee OA were investigated with respect to the relationship of knee OA severity with BMD...
December 2014: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/24948038/relationship-between-leptin-and-adiponectin-concentrations-in-plasma-and-femoral-and-spinal-bone-mineral-density-in-spinal-cord-injured-individuals
#10
Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Farzad Shidfar, Mohammad Reza Vafa, Seyed-Hassan Emami Razavi, Bagher Larijani, Ramin Heshmat
BACKGROUND CONTEXT: Previously, the associations between leptin and adiponectin levels with bone mineral density (BMD) have been reported in different populations, and occasionally, controversial results have been demonstrated. Until now, these relationships in spinal cord-injured individuals have not yet been described. PURPOSE: We tried to investigate the correlation between leptin and adiponectin concentrations in plasma and BMD in Iranian patients with spinal cord injury (SCI)...
January 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/24898537/odanacatib-treatment-affects-trabecular-and-cortical-bone-in-the-femur-of-postmenopausal-women-results-of-a-two-year-placebo-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Klaus Engelke, Thomas Fuerst, Bernard Dardzinski, John Kornak, Shabana Ather, Harry K Genant, Anne de Papp
Odanacatib, a selective cathepsin K inhibitor, increases areal bone mineral density (aBMD) at the spine and hip of postmenopausal women. To gain additional insight into the effects on trabecular and cortical bone, we analyzed quantitative computed tomography (QCT) data of postmenopausal women treated with odanacatib using Medical Image Analysis Framework (MIAF; Institute of Medical Physics, University of Erlangen, Erlangen, Germany). This international, randomized, double-blind, placebo-controlled, 2-year, phase 3 trial enrolled 214 postmenopausal women (mean age 64 years) with low aBMD...
January 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/24038152/the-effect-of-the-cathepsin-k-inhibitor-ono-5334-on-trabecular-and-cortical-bone-in-postmenopausal-osteoporosis-the-ocean-study
#12
RANDOMIZED CONTROLLED TRIAL
Klaus Engelke, Shinichi Nagase, Thomas Fuerst, Maria Small, Tomohiro Kuwayama, Stephen Deacon, Richard Eastell, Harry K Genant
ONO-5334 (Ono Pharmaceutical Co., Ltd., Osaka, Japan) inhibits cathepsin K and has been shown to increase areal bone mineral density (BMD) at the hip and spine in postmenopausal osteoporosis. Quantitative computed tomography (QCT) allows the study of the cortical and trabecular bone separately and provides structural information such as cortical thickness. We investigated the impact of 2 years of cathepsin K inhibition on these different bone compartments with ONO-5334. The clinical study was a randomized, double-blind, placebo, and active controlled parallel group study conducted in 13 centers in six European countries...
March 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/24002345/adolescent-physical-activity-and-bone-strength-at-the-proximal-femur-in-adulthood
#13
Stefan A Jackowski, Saija A Kontulainen, David M L Cooper, Joel L Lanovaz, Thomas J Beck, Adam D G Baxter-Jones
INTRODUCTION: Physical activity (PA) enhances bone structural strength at the proximal femur in adolescence, but whether these benefits are maintained into early adulthood remains unknown. The purpose of this study was to investigate whether males and females, described as active, average, and inactive during adolescence, display differences in structural strength at the proximal femur in early adulthood (20-30 yr). METHODS: One hundred four participants (55 males and 49 females) from the Pediatric Bone Mineral Accrual Study (PBMAS) were categorized into adolescent PA groupings (inactive, average, and active) using the Physical Activity Questionnaire for Adolescents...
April 2014: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/23893256/operative-treatment-of-fai-open-hip-preservation-surgery
#14
Michael D Hellman, Andrew J Riff, Bryan D Haughom, Rikesh Patel, Michael D Stover, Shane J Nho
Femoroacetabular Impingement (FAI) is characterized by abnormal contact of the hip joint. Many etiologies cause this painful condition, which leads to early osteoarthritis. While hip arthroscopy has become the most prevalent way to surgically correct a hip, some presentations of FAI require open surgical hip preservation techniques to fully address the pathology at hand. Certain head neck deformities may require open surgical hip dislocation utilizing a trochanteric slide osteotomy. A retroverted acetabulum may require an open periacetabular osteotomy to gain anteversion and eliminate impingement in the hip joint...
September 2013: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/23744478/pelvis-width-associated-with-bone-mass-distribution-at-the-proximal-femur-in-children-10-11-years-old
#15
Graça Cardadeiro, Fátima Baptista, Kathleen F Janz, Luís A Rodrigues, Luís B Sardinha
Differences in skeletal geometry may generate different patterns of mechanical loading to bone. Impact and muscle loading during physical activity have been shown to influence skeletal geometry. The purpose of this study was to compare geometric measures of the pelvis and proximal femur (PF) of young children and to analyze the contribution and potential interaction of these geometric measures with physical activity on PF bone mass distribution. Participants were 149 girls and 145 boys, aged 10-11 years. Total body and left hip DXA scans were used to derive pelvic and PF geometric measures and PF bone mineral density (BMD) at the femoral neck (FN), trochanter (TR), and intertrochanter (IT)...
March 2014: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/23722912/structural-strength-development-at-the-proximal-femur-in-4-to-10-year-old-precompetitive-gymnasts-a-4-year-longitudinal-hip-structural-analysis-study
#16
Rita Gruodyte-Raciene, Marta C Erlandson, Stefan A Jackowski, Adam Dg Baxter-Jones
Gymnastics, a high-impact weight-bearing physical activity, has been shown to be highly osteogenic. Previously in this cohort, bone mass development (bone mineral content accrual [BMC]) was shown to be positively associated with low-level (recreational) gymnastics exposure (1 to 2 hours per week); however, BMC is only one single component of bone strength. Bone strength is influenced not only by bone mineralization but also bone geometry, bone architecture, and the imposing loads on the bone. The aim of this study was to investigate whether low-level gymnastics training influenced the estimated structural geometry development at the proximal femur...
December 2013: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/23719860/distribution-of-bone-density-and-cortical-thickness-in-the-proximal-femur-and-their-association-with-hip-fracture-in-postmenopausal-women-a-quantitative-computed-tomography-study
#17
L Yang, W J M Udall, E V McCloskey, R Eastell
UNLABELLED: The quantitative computed tomography (QCT) scans in an individually matched case-control study of women with hip fracture were analysed. There were widespread deficits in the femoral volumetric bone mineral density (vBMD) and cortical thickness of cases, and cortical vBMD and thickness discriminated hip fracture independently of BMD by dual-energy X-ray absorptiometry (DXA). INTRODUCTION: Acknowledging the limitations of QCT associated with partial volume effects, we used QCT in an individually matched case-control study of women with hip fracture to better understand its structural basis...
January 2014: Osteoporosis International
https://www.readbyqxmd.com/read/23715738/low-bone-mineral-density-is-associated-with-metabolic-syndrome-in-south-korean-men-but-not-in-women-the-2008-2010-korean-national-health-and-nutrition-examination-survey
#18
Yang-Hyun Kim, Kyung-Hwan Cho, Youn Seon Choi, Seon-Mee Kim, Ga-Eun Nam, Seung-Hwan Lee, Byung-Joon Ko, Yong-Gyu Park, Kyung Do Han, Kyung-Shik Lee, Do-Hoon Kim
UNLABELLED: We examined the relationships between bone mineral density (BMD) and metabolic syndrome in 6,659 men and 7,826 women from South Korean. After adjusting for age, body mass index (BMI), tobacco and alcohol use, and regular exercise, low BMD is especially associated with metabolic syndrome in South Korean men. PURPOSE: This study examined the relationships between BMD and metabolic syndrome (MS) in South Korean adults. METHODS: A total of 14,485 adults (6,659 men and 7,826 women) in the Korea National Health and Nutrition Examination Survey conducted from 2008 to 2010 were analyzed...
2013: Archives of Osteoporosis
https://www.readbyqxmd.com/read/23436924/association-of-dxa-derived-bone-mineral-density-and-fat-mass-with-african-ancestry
#19
Heather M Ochs-Balcom, Leah Preus, Jean Wactawski-Wende, Jing Nie, Nicholas A Johnson, Fouad Zakharia, Hua Tang, Chris Carlson, Cara Carty, Zhao Chen, Thomas Hoffman, Carolyn M Hutter, Rebecca D Jackson, Robert C Kaplan, Li Li, Song Liu, Marian L Neuhouser, Ulrike Peters, John Robbins, Michael F Seldin, Timothy A Thornton, Cheryl L Thompson, Charles Kooperberg, Lara E Sucheston
CONTEXT: Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups. OBJECTIVE: We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry. SETTING/PARTICIPANTS: We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available...
April 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23209801/sex-specific-association-of-physical-activity-on-proximal-femur-bmd-in-9-to-10-year-old-children
#20
Graça Cardadeiro, Fátima Baptista, Rui Ornelas, Kathleen F Janz, Luís B Sardinha
The results of physical activity (PA) intervention studies suggest that adaptation to mechanical loading at the femoral neck (FN) is weaker in girls than in boys. Less is known about gender differences associated with non-targeted PA levels at the FN or other clinically relevant regions of the proximal femur. Understanding sex-specific relationships between proximal femur sensitivity and mechanical loading during non-targeted PA is critical to planning appropriate public health interventions. We examined sex-specific associations between non-target PA and bone mineral density (BMD) of three sub-regions of the proximal femur in pre- and early-pubertal boys and girls...
2012: PloS One
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