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https://www.readbyqxmd.com/read/28532364/evolution-of-concepts-and-technologies-in-ophthalmic-laser-therapy
#1
Daniel Palanker
Ophthalmology was the first medical specialty to adopt lasers right after their invention more than 50 years ago, and they gradually revolutionized ocular imaging, diagnostics, therapy, and surgery. Challenging precision, safety, and selectivity requirements for ocular therapeutic and surgical procedures keep advancing the laser technologies, which in turn continue enabling novel applications for the preservation and restoration of sight. Modern lasers can provide single-cell-layer selectivity in therapy, submicrometer precision in three-dimensional image-guided surgery, and nondamaging retinal therapy under optoacoustic temperature control...
October 14, 2016: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28525469/safety-and-efficacy-study-of-an-ozone-laser-combined-therapy-using-puncture-needle-in-the-treatment-of-patients-with-cervical-spondylosis
#2
Ke Gu, Yuqiu Yan, Wu Wei, Yan Li, Wenli Liu, Yang Guo, Long Yu
STUDY DESIGN AND METHODS: Fifty-eight patients with cervical spondylosis (CS) were treated with patented technology of ozone laser combined therapy using puncture needle between August 2008 and February 2010. Visual Analogue Scale (VAS) score changes before and 6 months after surgery and MacNab score criteria 6 months after surgery were analyzed. BACKGROUND AND OBJECTIVE: CS normally occurs over the age of 50 and broadly presents as either myelopathy or radiculopathy...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525303/low-level-laser-therapy-after-wisdom-teeth-surgery-evaluation-of-immunologic-markers-secretory-immunoglobulin-a-and-lysozyme-levels-and-thermographic-examination-placebo-controlled-study
#3
Tatjana Dostalova, Veronika Kroulikova, Stepan Podzimek, Helena Jelinková
OBJECTIVE: The goal of this investigation is to analyze the effect of therapeutic low-level laser therapy (LLLT) to have a possibility to check pain and inflammation connected with surgical removal of impacted lower third molars in general anesthesia or even phobia [not accompanied by pain or fear of dental treatment, using immunologic markers-secretory immunoglobulin A (sIgA) and lysozyme]. The healing process was also monitored by infrared thermography. BACKGROUND DATA: LLLT can accelerate the proliferation phase of healing and decrease the inflammatory reaction, but the effect is not really clear...
May 16, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28524144/-new-approaches-to-the-treatment-of-keratoconjunctivitis-sicca
#4
T N Safonova, O V Gladkova, I A Novikov, V I Boev, A A Fedorov
A new method has been developed for the treatment of severe forms of keratoconjunctivitis sicca (KCS) that involves the use of an original cyclosporine A (CyA) saturated soft contact lens (SCL) together with preservative-free artificial tears therapy. AIM: to evaluate the effectiveness of the newly developed treatment for KCS based on the use of medical SCL saturated with 0.05% CyA. MATERIAL AND METHODS: The patients (43 men, 60 eyes) with severe KCS were divided into 2 groups...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28512669/combined-fractional-treatment-of-acne-scars-involving-non-ablative-1-550-nm-erbium-glass-laser-and-micro-needling-radiofrequency-a-16-week-prospective-randomized-split-face-study
#5
Hyuck Hoon Kwon, Hae Young Park, Sun Chul Choi, Youin Bae, Chanhee Kang, Jae Yoon Jung, Gyeong-Hun Park
An optimized therapeutic regimen involving a non-ablative fractionated laser or radiofrequency therapy for acne scars has not yet been established. To evaluate whether the combination of a non-ablative fractional laser (NAF) and fractional micro-needling radiofrequency (FMR) has clinical advantages for the treatment of atrophic acne scars compared with NAF alone, a 16-week prospective, randomized split-face study was performed. Each facial side of a patient was treated with 3 sessions of either NAF with FMR or NAF alone, with a 4-week interval between each session...
May 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28511143/dna-assisted-upconversion-nanoplatform-for-imaging-guided-synergistic-therapy-and-laser-switchable-drug-detoxification
#6
Luoyuan Li, Panlong Hao, Peng Wei, Limin Fu, Xicheng Ai, Jianping Zhang, Jing Zhou
The side effects of chemotherapy bring significant physical and psychological suffering to patients. To solve this urgent medical problem, Yb(3+) and Er(3+) co-doped NaLuF4 upconversion nanoparticles (UCNPs) were constructed for upconversion luminescence (UCL)-labeled diagnosis under 980 nm laser irradiation. The UCNPs were then modified layer by layer with polypyrrole and a special programming DNA segment as photothermal conversion agents and controllable drug carriers, respectively. The nanoplatform was successfully used for imaging-guided synergistic therapy (photothermal therapy and chemotherapy) at a safe power density (300 mW cm(-2)), and DNA-assisted detoxification at lower temperature in cancer cells when the laser off...
May 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28507428/propranolol-therapy-for-infantile-hemangioma-our-experience
#7
Ling Zhang, Hai-Wei Wu, Weien Yuan, Jia-Wei Zheng
OBJECTIVE: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28502693/prolonged-blood-brain-barrier-disruption-following-laser-interstitial-ablation-in-epilepsy-a-case-series-with-a-case-report-of-post-ablation-optic-neuritis
#8
Saint-Aaron Morris, Matthew Rollo, Patrick Rollo, Jessica Johnson, Gerald A Grant, Elliott Friedman, Giridhar Kalamangalam, Nitin Tandon
OBJECTIVE: Laser interstitial thermal therapy (LITT) has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in more than a thousand patients, the chronic effects of photo-thermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed the clinical and radiographic courses of a cohort undergoing laser ablation for focal epilepsy. Only patients with non-enhancing lesions and those who had a delayed post-operative MRI with gadolinium administration approximately 6 months after the ablation were considered...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28497661/medication-related-osteonecrosis-of-the-jaw-risk-factors-in-patients-under-biphosphonate-versus-patients-under-antiresorptive-antiangiogenic-drugs
#9
Giulia Ghidini, Maddalena Manfredi, Ilaria Giovannacci, Giovanni Mergoni, Amin Sarraj, Maura Mureddu, Giovanna Giunta, Mauro Bonanini, Marco Meleti, Paolo Vescovi
BACKGROUND: Biphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is a potential side effect associated with the administration of bisphosphonates; the aim of this work is to highlight the possible epidemiological differences between two groups of patients affected by MRONJ treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, Italy, between January 2004 and June 2016. METHODS: Medical charts of 303 patients (214 Females and 89 Males, mean age 67y) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, between January 2004 and June 2016, were retrospectively analyzed...
May 10, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28494960/laser-activated-polymeric-microcapsules-for-ultrasound-imaging-and-therapy-in%C3%A2-vitro-feasibility
#10
Guillaume Lajoinie, Tom van Rooij, Ilya Skachkov, Emilie Blazejewski, Gert Veldhuis, Nico de Jong, Klazina Kooiman, Michel Versluis
Polymeric microcapsules with a light-absorbing dye incorporated in their shell can generate vapor microbubbles that can be spatiotemporally controlled by pulsed laser irradiation. These contrast agents of 6-8 μm in diameter can circulate through the vasculature, offering possibilities for ultrasound (molecular) imaging and targeted therapies. Here, we study the impact of such vapor bubbles on human endothelial cells in terms of cell poration and cell viability to establish the imaging and therapeutic windows...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28489273/low-level-light-minoxidil-5-combination-versus-either-therapeutic-modality-alone-in-management-of-female-patterned-hair-loss-a-randomized-controlled-study
#11
Samia M Esmat, Rehab A Hegazy, Heba I Gawdat, Rania M Abdel Hay, Riham S Allam, Rofaida El Naggar, Hoda Moneib
BACKGROUND: Female pattern hair loss (FPHL) is the most common form of hair loss in women. Nevertheless, its management represents a real challenge. Among the FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT). AIM OF WORK: Assess the efficacy and safety of LLLT in comparison to topical minoxidil 5% and to a combination of both therapies in the treatment of FPHL. PATIENTS AND METHODS: This study included 45 female patients with proven FPHL...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28484754/dual-modal-imaging-guided-highly-efficient-photothermal-therapy-using-heptamethine-cyanine-conjugated-hyaluronic-acid-micelles
#12
Sanpeng Li, Zhihong Sun, Guanjun Deng, Xiaoqing Meng, Wenjun Li, Dapeng Ni, Jiali Zhang, Ping Gong, Lintao Cai
Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy and reduce the side effects of theranostics. Herein, we constructed novel biocompatible cyanine dye IR808-conjugated hyaluronic acid nanoparticles (HAIR NPs) for photothermal therapy (PTT) with near-infrared fluorescence (FL) and photoacoustic (PA) dual-modal imaging. The nanoparticles formed stable nanostructures under aqueous conditions with uniform size distribution. The HAIR NPs were rapidly taken up by the human lung cancer cells A549 via CD44 (the hyaluronic acid receptor on the surface of tumor cells) receptor-mediated endocytosis...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28469359/probe-confocal-laser-endomicroscopy-in-the-therapeutic-endoscopic-management-of-barrett-s-dysplasia
#13
Fabrice Caillol, Sebastien Godat, Flora Poizat, Aurélie Auttret, Christian Pesenti, Erwan Bories, Jean Phillipe Ratone, Marc Giovannini
BACKGROUND: Endoscopic management of Barrett's esophagus (BE) depends on the histological stage of BE and includes the following: follow up, endotherapy with thermal ablation, and piecemeal or monobloc endoscopic resection (ER). We know that biopsies are unreliable in 20-75% of cases. The aim of our study was to evaluate the efficiency of probe confocal laser endomicroscopy (pCLE) in the diagnosis of the histological stage of BE, compared with the final histological results after ER. METHODS: This retrospective study was based on a prospective registry of patients referred for management of BE-associated dysplasia...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28466193/efficacy-of-nd-yag-laser-therapy-for-the-treatment-of-verrucae-a-literature-review
#14
Vincent M Hsu, Adam S Aldahan, John P Tsatalis, Marina Perper, Keyvan Nouri
Verrucae are benign epithelial proliferations, characteristically 1-20 mm in diameter, caused by human papilloma virus (HPV) infection occurring on the skin and mucosa (Photomed Laser Surg 33(6):338-42, 2015; Lasers Med Sci 29(3):1111-6, 2014). Prevalence of verrucae is 5-20% in children and young adults with peak incidence reported during teenage years (Lasers Med Sci 29(3):1111-6, 2014; J Am Acad Dermatol 22(4):547-66, 1990; J Korean Med Sci 24(5):889-93, 2009). Patients often express significant displeasure with quality of life due to this cosmetic insecurity, as well as functional problems and physical discomfort when they occur on palms of hands and soles of feet...
May 2, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28465165/chlorin-e6-conjugated-copper-sulfide-nanoparticles-for-photodynamic-combined-photothermal-therapy
#15
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Nhat Quang Bui, Kang Dae Lee, Junghwan Oh
The photo-based therapeutic approaches have attracted tremendous attention in recent years especially in treatment and management of tumors. Photodynamic and photothermal are two major therapeutic modalities which are being applied in clinical therapy. The development of nanomaterials for photodynamic combined photothermal therapy has gained significant attention for its treatment efficacy. In the present study, we designed chlorin e6 (Ce6) conjugated copper sulfide (CuS) nanoparticles (CuS-Ce6 NPs) through amine functionalization and the synthesized nanoparticles act as a dual-model agent for photodynamic therapy and photothermal therapy...
April 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28454272/dinitrophenyl-hapten-with-laser-immunotherapy-for-advanced-malignant-melanoma-a-clinical-study
#16
Dian-Jun Chen, Xiao-Song Li, Hui Zhao, Yan Fu, Huan-Rong Kang, Fang-Fang Yao, Jia Hu, Nan Qi, Huan-Huan Zhang, Nan Du, Wei-R Chen
The present study aimed to evaluate the efficacy and safety of in situ immunotherapy with dinitrophenyl (DNP) hapten in combination with laser therapy for patients with malignant melanoma (MM). Between February 2008 and March 2012, 72 patients with stage III or IV MM were enrolled. Patients received in situ DNP alone (n=32) or in combination with laser therapy (n=32), and each group received dacarbazine chemotherapy. The levels of peripheral cluster of differentiation (CD)4(+)CD25(+) regulatory T cells (Tregs), interleukin (IL)-10 and tumor growth factor (TGF)-β were detected by ELISA...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451704/-benign-tumours-and-tumour-like-lesions-of-the-bone-general-treatment-principles
#17
REVIEW
H Fritzsche, K-D Schaser, C Hofbauer
BACKGROUND: Benign bone lesions are much more common than malignant lesions. Some benign bone tumors have a characteristic and typical radiographic appearance, while others are more challenging. Therapy of benign bone tumors differs greatly. While the majority of benign bone tumors do not require surgical therapy, other specific lesions, e. g. aneurysmal bone cysts or giant cell tumors (GCT) of the bone require surgery due to their locally aggressive behavior. DIAGNOSTICS: The major challenge for the radiologist and/or pathologist is the differentiation between a benign and low-grade malignant lesion (e...
April 27, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28451112/polydopamine-coated-manganese-oxide-nanoparticles-with-ultrahigh-relaxivity-as-nanotheranostic-agents-for-magnetic-resonance-imaging-guided-synergetic-chemo-photothermal-therapy
#18
Xing Ding, Jianhua Liu, Junqi Li, Fan Wang, Yinghui Wang, Shuyan Song, Hongjie Zhang
Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn3O4@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM(-1) s(-1) makes the nanotheranostic an excellent contrast agent for MRI in vitro and in vivo, and provides comprehensive information for tumor diagnosis...
November 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28450782/gold-nanorod-based-poly-lactic-co-glycolic-acid-with-manganese-dioxide-core-shell-structured-multifunctional-nanoplatform-for-cancer-theranostic-applications
#19
Lei Wang, Dong Li, Yongwei Hao, Mengya Niu, Yujie Hu, Hongjuan Zhao, Junbiao Chang, Zhenzhong Zhang, Yun Zhang
Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO2) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO4 to construct the PLGA/AuNR/DTX@MnO2 drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28450262/evaluation-of-photodynamic-therapy-in-treatment-of-oral-erosive-lichen-planus-in-comparison-with-topically-applied-corticosteroids
#20
Diana Mostafa, Eglal Moussa, Manal Alnouaem
BACKGROUND: The treatment of erosive oral lichen planus represents a therapeutic challenge. Despite numerous existing remedies, some of these treatments display disappointed results. Since it is a chronic disease with no current cure, the best treatment should target mainly the reduction of the duration and severity of symptomatic outbreaks with minimal side effects. To date, corticosteroids remain the first choice of treatment for oral lichen planus (OLP) patients. Although, topical corticosteroids have been found to be the safest and the most successful agents in the treatment of OLP, their prolonged use may cause mucosal problems and may lead to systemic complications...
April 24, 2017: Photodiagnosis and Photodynamic Therapy
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