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https://www.readbyqxmd.com/read/28210823/non-ablative-erbium-yag-laser-for-the-treatment-of-type-iii-stress-urinary-incontinence-intrinsic-sphincter-deficiency
#1
Adrian Gaspar, Hugo Brandi
The objective of this pilot study was to determine the safety and efficacy of a new non-ablative erbium YAG laser procedure for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency) in women. Twenty-two patients with a Valsalva leak point pressure less than 60 cm H2O were recruited and treated with a non-ablative erbium laser delivering low fluence pulses inside the whole length of the urethra through a specially designed cannula. Treatment consisted of two treatment sessions with a 3-week interval in-between...
February 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28210023/application-of-diode-laser-in-the-treatment-of-dentine-hypersensitivity
#2
Mirjana Gojkov-Vukelic, Sanja Hadzic, Amila Zukanovic, Enes Pasic, Veriva Pavlic
INTRODUCTION: Dentine hypersensitivity is characterized by acute, sharp pain arising from the exposed dentine, most commonly in response to thermal, tactile, or chemical stimuli, and which cannot be linked to any other pathological changes in the tooth or the environment. Therapy uses various impregnating agents in the form of solutions or gels and, in more recent times, laser. AIM: The aim of this research was to examine the effects of treatment of hypersensitive dental cervix with diode laser...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28197794/therapeutic-options-in-refractory-diabetic-macular-oedema
#3
Sanket U Shah, Raj K Maturi
Diabetic macular oedema (DMO) results from alterations of several biochemical pathways in diabetic eyes. Centre-involving DMO is an important cause of visual loss in diabetes. Anti-vascular endothelial growth factor agents are now the mainstay of centre-involving DMO treatment. Oedema that does not achieve optimal response to these agents occurs in a sizeable proportion of eyes and is called refractory or persistent DMO. Management of refractory DMO is challenging. In this paper, the pathophysiology of DMO, and the definitions used in various studies are summarised...
February 15, 2017: Drugs
https://www.readbyqxmd.com/read/28195845/an-analysis-of-laser-therapy-for-the-treatment-of-nonmelanoma-skin-cancer
#4
Teo Soleymani, Michael Abrouk, Kristen M Kelly
BACKGROUND: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. OBJECTIVE: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option...
February 9, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28194375/rehabilitation-of-hamstring-muscle-injuries-a-literature-review
#5
REVIEW
Gabriel Amorim Ramos, Gustavo Gonçalves Arliani, Diego Costa Astur, Alberto de Castro Pochini, Benno Ejnisman, Moisés Cohen
Hamstring injuries are among the most frequent in sports. The high relapse rate is a challenge for sports medicine and has a great impact on athletes and sport teams. The treatment goal is to provide the athlete the same functional level as before the injury. Thus, functional rehabilitation is very important to the success of the treatment. Currently, several physical therapy modalities are used, according to the stage of the lesion, such as cryotherapy, laser therapy, therapeutic ultrasound, therapeutic exercise, and manual therapy...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28183070/remotely-controlled-drug-release-based-on-iron-oxide-nanoparticles-for-specific-therapy-of-cancer
#6
Lin Wu, Ling Chen, Fei Liu, Xueyong Qi, Yanru Ge, Song Shen
Chemotherapy has been widely used in clinic and usually causes serious side effects. To improve therapeutic effect, it is really necessary to realize local drug release and specific therapy. In this work, we demonstrate Azo (4,4-azobis (4-cyanovaleric acid))-functionalized multifunctional nanoparticles to realize near-infrared (NIR) laser-responsive drug release and combined chemo-photothermal cancer therapy. Doxorubicin (DOX) was attached to magnetic nanoparticles via a thermal-cleavable Azo linker, which could decompose while the temperature reach ∼43°C...
January 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28181461/d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-functionalized-nanographene-oxide-for-cancer-therapy
#7
Duarte de Melo-Diogo, Cleide Pais-Silva, Elisabete C Costa, Ricardo O Louro, Ilídio J Correia
AIM: To evaluate the therapeutic capacity of D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. METHODS: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. RESULTS: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1...
February 9, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28169477/localised-intravascular-coagulation-complicating-venous-malformations-in-children-associations-and-therapeutic-options
#8
REVIEW
Kevin Y Zhuo, Susan Russell, Orli Wargon, Susan Adams
Venous malformations are slow-flow congenital vascular malformations that enlarge as the child ages and may be associated with localised intravascular coagulation, a consumptive coagulopathy characterised by elevated D-dimer and decreased fibrinogen levels. The authors review the known correlations between localised intravascular coagulation and venous malformation number, size and planes involved, and call attention to the concept of the progression of localised intravascular coagulopathy as the child ages and their venous malformations enlarge...
February 7, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28165223/tumor-penetrating-nanoparticles-for-enhanced-anticancer-activity-of-combined-photodynamic-and-hypoxia-activated-therapy
#9
Yazhe Wang, Ying Xie, Jing Li, Zheng-Hong Peng, Yuri Sheinin, Jianping Zhou, David Oupický
Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood vessels results in inadequate exposure to antitumor therapeutics and contributes to development of chemoresistance and increased metastasis. In the present study, we developed iRGD-modified nanoparticles for simultaneous tumor delivery of a photosensitizer indocyanine green (ICG) and hypoxia-activated prodrug tirapazamine (TPZ). The iRGD-modified nanoparticles loaded with ICG and TPZ showed significantly improved penetration in both 3D tumor spheroids in vitro and orthotopic breast tumors in vivo...
February 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28165076/zwitterionic-gold-nanorods-low-toxicity-and-high-photothermal-efficacy-for-cancer-therapy
#10
Huangyong Jiang, Dong Chen, Dongbo Guo, Nan Wang, Yue Su, Xin Jin, Gangsheng Tong, Xinyuan Zhu
Novel "zwitterionic" gold nanorods (Au NRs) were constructed through a facile ligand exchange process between cetyltrimethylammonium bromide (CTAB)-Au NRs and the zwitterionic block polymer {poly(2-methacryloyloxyethyl phosohorylcholine)-b-poly(lipoic methacrylate) (pMPC-b-pLA)}. In vitro, they exhibited low dark cytotoxicity and a high therapeutic efficacy to cancer cells. Their blood circulation half-life in vivo (t1/2, ∼10 h) was 20-fold longer than that of CTAB-Au NRs (t1/2, <30 min). After intravenous administration, they accumulated in tumour sites via an enhanced permeability and retention (EPR) effect and enabled destruction of human xenograft tumours in mice after exposure of the tumour location to NIR laser irradiation at 808 nm...
February 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28164460/development-and-application-of-led-arrays-for-use-in-phototherapy-research
#11
Mohammed A Hadis, Paul R Cooper, Michael R Milward, Patricia C Gorecki, Edward Tarte, James Churm, William M Palin
Lasers/LEDs demonstrate therapeutic effects for a range of biomedical applications. However, a consensus on effective light irradiation parameters and efficient and reliable measurement techniques remain limited. The objective here is to develop, characterise and demonstrate the application of LED arrays in order to progress and improve the effectiveness and accuracy of in vitro photobiomodulation studies. 96-well plate format LED arrays (400-850 nm) were developed and characterised to accurately assess irradiance delivery to cell cultures...
February 6, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28161572/single-wavelength-light-mediated-synergistic-bimodal-cancer-photoablation-and-amplified-photothermal-performance-by-graphene-gold-nanostar-photosensitizer-theranostics
#12
Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, Yuan Tian, Hong Yang, Shun Li, Yiyao Liu
: Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy (PTT) as well as effective photothermal imaging. The stable and biocompatible GO/AuNS-PEG composite displayed a high photothermal conversion efficiency due to the enhanced optical absorbance of both graphene and gold nanostars in the near-infrared (NIR) range...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28160445/gold-nanoparticle-mediated-photothermal-therapy-applications-and-opportunities-for-multimodal-cancer-treatment
#13
REVIEW
Rachel S Riley, Emily S Day
Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat in response to exogenously applied laser light, has been well documented as an independent strategy for highly selective cancer treatment. Gold-based nanoparticles are the main mediators of PTT because they offer: (1) biocompatibility, (2) small diameters that enable tumor penetration upon systemic delivery, (3) simple gold-thiol bioconjugation chemistry for the attachment of desired molecules, (4) efficient light-to-heat conversion, and (5) the ability to be tuned to absorb near-infrared light, which penetrates tissue more deeply than other wavelengths of light...
February 3, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28159715/dual-function-nanostructured-lipid-carriers-to-deliver-ir780-for-breast-cancer-treatment-anti-metastatic-and-photothermal-anti-tumor-therapy
#14
Huipeng Li, Kaikai Wang, Xue Yang, Yiwen Zhou, Qineng Ping, David Oupicky, Minjie Sun
: Cancer treatments that use a combination of approaches with the ability to affect multiple disease pathways have proven highly effective. The present study reports on CXCR4-targeted nanostructured lipid carriers (NLCs) with a CXCR4 antagonist AMD3100 in the shell (AMD-NLCs). AMD-NLCs loaded with IR780 (IR780-AMD-NLCs) reduced the invasiveness of cancer cells, while simultaneously mediating efficient tumor targeting and photothermal therapeutic outcomes. We present the combined effect of encapsulated IR780 on photothermal therapy and of the AMD3100 coating on tumor targeting, CXCR4 antagonism and inhibition of cancer cell invasion and breast cancer lung metastasis in vitro and in vivo...
January 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28157634/hollow-mesoporous-carbon-as-a-near-infrared-absorbing-carrier-compared-with-mesoporous-carbon-nanoparticles-for-chemo-photothermal-therapy
#15
Xian Li, Yue Yan, Yuanzhe Lin, Jian Jiao, Da Wang, Donghua Di, Ying Zhang, Tongying Jiang, Qinfu Zhao, Siling Wang
In this study, hollow mesoporous carbon nanoparticles (HMCN) and mesoporous carbon nanoparticles (MCN) were used as near-infrared region (NIR) nanomaterials and drug nanocarriers were prepared using different methods. A comparison between HMCN and MCN was performed with regard to the NIR-induced photothermal effect and drug loading efficiency. The results of NIR-induced photothermal effect test demonstrated that HMCN-COOH had a better photothermal conversion efficacy than MCN-COOH. Given the prominent photothermal effect of HMCN-COOH in vitro, the chemotherapeutic drug DOX was chosen as a model drug to further evaluate the drug loading efficiencies and NIR-triggered drug release behaviors of the nanocarriers...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28155894/photothermal-therapeutic-application-of-gold-nanorods-porphyrin-trastuzumab-complexes-in-her2-positive-breast-cancer
#16
Xinmei Kang, Ximing Guo, Weiwei An, Xingjian Niu, Suhan Li, Zhaoliang Liu, Yue Yang, Na Wang, Qicheng Jiang, Caichuan Yan, Hui Wang, Qingyuan Zhang
Gold nanorods are effective photothermal agents in diagnosis and treatment of cancer due to their specific near-infrared laser absorption. However, tumor photothermal therapy by nanorods alone is lack of targeting. Here, we described a novel nanocomplex made up of gold nanorods, porphyrin, and trastuzumab, called TGNs and investigated the TGN-mediated photothermal therapy as a potential alternative treatment of targeting HER2-positive breast cancers. By conjugating trastuzumab and porphyrin to the surface of gold nanorods, we have increased the targeting specificity and amplified the detecting effectiveness at the same time...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154914/laser-therapy-as-a-treatment-modality-for-genitourinary-syndrome-of-menopause-a-critical-appraisal-of-evidence
#17
Angamuthu Arunkalaivanan, Hervinder Kaur, Oseka Onuma
Interest in laser therapy as a nonhormonal option for the treatment of genitourinary syndrome of menopause (GSM) has increased. We conducted a systematic review of the use of laser therapy for the relief of GSM symptoms. Six electronic databases were searched and conference abstracts were searched manually from the introduction of laser therapy to the present date. The keywords used were: "genitourinary syndrome", "vulvovaginal atrophy", "postmenopausal symptoms", "laser therapy" and "fractional laser treatment"...
February 2, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28138214/racial-differences-in-selective-laser-trabeculoplasty-efficacy
#18
Emil Goosen, Kate Coleman, Linda Visser, William E Sponsel
AIM: Sub-Saharan Africa has a population of 1 billion, with one ophthalmologist per million people. Basic ophthalmic support services are virtually absent for all but a few urban populations. Minimally invasive laser treatment may help. This study reports our initial experience using selective laser trabeculoplasty (SLT) in a mixed-racial population of adult glaucoma patients in Durban, South Africa. STUDY DESIGN: Institution Review Board approved the 5-year chart review...
January 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28132907/gene-therapy-for-diabetic-retinopathy-are-we-ready-to-make-the-leap-from-bench-to-bedside
#19
REVIEW
Jiang-Hui Wang, Damien Ling, Leilei Tu, Peter van Wijngaarden, Gregory J Dusting, Guei-Sheung Liu
Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that further damages vision. A major contributor to the pathology is excess production of vascular endothelial growth factor (VEGF), a growth factor that induces formation of new blood vessels and increases permeability of existing vessels. Despite the recent availability of effective treatments for the disease, including laser photocoagulation and therapeutic VEGF antibodies, DR remains a significant cause of vision loss worldwide...
January 27, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28130821/a-monte-carlo-approach-to-the-microdosimetric-kinetic-model-to-account-for-dose-rate-time-structure-effects-in-ion-beam-therapy-with-application-in-treatment-planning-simulations
#20
Lorenzo Manganaro, Roberto Cirio, Federico Dalmasso, Vincenzo Monaco, Roberto Sacchi, Germano Russo, Simona Giordanengo, Anna Vignati, Andrea Attili, Silvia Muraro
PURPOSE: Advanced ion beam therapeutic techniques, such as hypofractionation, respiratory gating, or laser-based pulsed beams, have dose rate time structures which are substantially different from those found in conventional approaches. The biological impact of the time structure is mediated through the β parameter in the linear quadratic (LQ) model. The aim of this study is to assess the impact of changes in the value of the β parameter on the treatment outcomes, also accounting for non instantaneous intra-fraction dose delivery or fractionation and comparing the effects of using different primary ions...
January 28, 2017: Medical Physics
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