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https://www.readbyqxmd.com/read/28328287/photobiomodulation-with-non-thermal-lasers-mechanisms-of-action-and-therapeutic-uses-in-dermatology-and-aesthetic-medicine
#1
Mark Nestor, Anneke Andriessen, Brian Berman, Bruce E Katz, Dore Gilbert, David J Goldberg, Michael H Gold, Robert S Kirsner, Paul Z Lorenc
BACKGROUND: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light. OBJECTIVES: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology. METHODS: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis...
February 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28322514/strategies-to-improve-cancer-photothermal-therapy-mediated-by-nanomaterials
#2
REVIEW
Duarte de Melo-Diogo, Cleide Pais-Silva, Diana R Dias, André F Moreira, Ilídio J Correia
The deployment of hyperthermia-based treatments for cancer therapy has captured the attention of different researchers worldwide. In particular, the application of light-responsive nanomaterials to mediate hyperthermia has revealed promising results in several pre-clinical assays. Unlike conventional therapies, these nanostructures can display a preferential tumor accumulation and thus mediate, upon irradiation with near-infrared light, a selective hyperthermic effect with temporal resolution. Different types of nanomaterials such as those based on gold, carbon, copper, molybdenum, tungsten, iron, palladium and conjugated polymers have been used for this photothermal modality...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28316193/-clinical-study-on-the-corneal-epithelial-dysfunction-after-cataract-extraction
#3
J H Qu, Z Q Wang, Y Zhang, X G Sun
Objective: To study the clinical manifestations, diagnosis and treatment of corneal epithelial dysfunction after cataract extraction. Methods: Fifteen cases diagnosed as corneal epithelial dysfunction after cataract extraction between November 2014 and September 2016 were retrospectively analyzed, mainly including clinical manifestations, characteristics of morphological changes imaged by in vivo laser confocal microscopy, management and therapeutic effects. Results: There were 6 (40%) males and 9 (60%) females with an average age of 66±7 years (59 to 86 years)...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28315495/legumain-cleavable-4-arm-poly-ethylene-glycol-doxorubicin-conjugate-for-tumor-specific-delivery-and-release
#4
Huicong Zhou, Huanjiao Sun, Shixian Lv, Dawei Zhang, Xuefei Zhang, Zhaohui Tang, Xuesi Chen
Traditional chemotherapy strategy exists undesirable toxic side-effects to normal tissues due to the low selectively to cancer cells of micromolecule cytotoxic drugs. One considered method to realizing the targeted delivery and increasing the specificity to tumor tissues of the cytotoxic drug is to transporting and discharging it through an environment-sensitive mechanism. In this study, a novel enzyme-sensitive polymer-doxorubicin conjugate was designed to delivery chemotherapeutic drug in a tumor-specific behavior and selectively activated in tumor tissue...
March 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28301626/zoon-balanitis-revisited-report-of-balanitis-circumscripta-plasmacellularis-resolving-with-topical-mupirocin-ointment-monotherapy
#5
Michael A Lee, Philip R Cohen
<p>INTRODUCTION: Zoon balanitis is an idiopathic benign inflammatory condition of the glans penis and prepuce. A patient with biopsy confirmed diagnosis of Zoon balanitis who was successfully treated with topical mupirocin ointment monotherapy is described.</p> <p>METHOD: A search using PubMed database was performed using the following terms: Zoon balanitis (cases, diagnosis, treatment of), balanitis circumscripta plasmacellularis, and mupirocin. Relevant papers and their reference citations were reviewed and evaluated...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28298815/ethical-guidelines-animal-profile-various-animal-models-used-in-periodontal-research-with-alternatives-and-future-perspectives
#6
REVIEW
Mohan Kumar Pasupuleti, Subramanya Shetty Molahally, Supraja Salwaji
Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28296519/congenital-melanocytic-nevus-on-the-lower-eyelid-treated-with-continuous-wave-and-superpulsed-co2-laser-followed-by-erbium-laser
#7
Vito Abrusci, Valentina Benzecry
There are several therapeutic options to treat congenital melanocytic nevi. The motivations for the treatment of small- to medium-sized congenital nevi located on the face or other sensitive areas are frequently cosmetic. The choice of therapy depends on the operator's expertise and on the likelihood of improved cosmesis. We report a case of a medium-sized congenital nevi located on the lower eyelid, successfully treated with a combination of ablative lasers with a single surgical procedure. We achieved an excellent clinical and cosmetic result...
February 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28293102/paclitaxel-loaded-star-shaped-copolymer-nanoparticles-for-enhanced-malignant-melanoma-chemotherapy-against-multidrug-resistance
#8
Yongsheng Su, Jian Hu, Zhibin Huang, Yubin Huang, Bingsheng Peng, Ni Xie, Hui Liu
Malignant melanoma (MM) is the most dangerous type of skin cancer with annually increasing incidence and death rates. However, chemotherapy for MM is restricted by low topical drug concentration and multidrug resistance. In order to surmount the limitation and to enhance the therapeutic effect on MM, a new nanoformulation of paclitaxel (PTX)-loaded cholic acid (CA)-functionalized star-shaped poly(lactide-co-glycolide) (PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (NPs) (shortly PTX-loaded CA-PLGA-TPGS NPs) was fabricated by a modified method of nanoprecipitation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28283896/fluocinolone-acetonide-intravitreal-implant-0-19%C3%A2-mg-iluvien-%C3%A2-a-review-in-diabetic-macular-edema
#9
Yahiya Y Syed
Fluocinolone acetonide intravitreal implant 0.19 mg (ILUVIEN(®)) is a nonbiodegradable, injectable, corticosteroid implant that is approved in several countries, including the USA, for the treatment of diabetic macular edema (DME). ILUVIEN(®) releases fluocinolone acetonide at an initial rate of 0.25 µg/day (average rate 0.2 µg/day) and lasts 36 months. In the two pooled pivotal FAME trials in patients with DME previously treated with macular laser photocoagulation, fluocinolone acetonide intravitreal implant 0...
March 10, 2017: Drugs
https://www.readbyqxmd.com/read/28281457/evaluation-of-the-effect-of-sildenafil-on-the-microvascular-blood-flow-in-patients-with-systemic-sclerosis-a-randomised-double-blind-placebo-controlled-study
#10
Fernando V Andrigueti, Pâmela C C Ebbing, Maria I Arismendi, Cristiane Kayser
OBJECTIVES: To evaluate the effect of sildenafil as add-on therapy on the microvascular blood flow in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc). METHODS: In this double-blind, placebo-controlled study, 41 patients with RP secondary to SSc were randomly assigned to receive oral sildenafil 100 mg/day (21 patients, mean age 47.2 years) or placebo (20 patients, mean age 41.6 years) for 8 weeks. Patients were evaluated at baseline, 8 weeks after treatment, and 2 weeks after the end of the treatment...
March 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28280483/outer-plexiform-layer-structures-are-not-altered-following-aav-mediated-gene-transfer-in-healthy-rat-retina
#11
Bert C Giers, Daniela Klein, Alexandra Mendes-Madeira, Carolina Isiegas, Birgit Lorenz, Silke Haverkamp, Knut Stieger
Ocular gene therapy approaches have been developed for a variety of different diseases. In particular, clinical gene therapy trials for RPE65 mutations, X-linked retinoschisis, and choroideremia have been conducted at different centers in recent years, showing that adeno-associated virus (AAV)-mediated gene therapy is safe, but limitations exist as to the therapeutic benefit and long-term duration of the treatment. The technique of vector delivery to retinal cells relies on subretinal injection of the vector solution, causing a transient retinal detachment...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28274363/treatments-for-hidradenitis-suppurativa
#12
R Kjærsgaard Andersen, Gregor B E Jemec
Hidradenitis suppurativa (HS) is not easily treated. Although not uncommon, HS is often misdiagnosed outside specialized clinics and inappropriately treated as a simple boil or abscess. In recent years, guidelines have been developed on the basis of expert opinion and the available literature. A multifaceted approach is necessary as HS lesions include both inflammation (amenable to medical treatment) as well as fibrosis (amenable to surgery only). The recommended antiinflammatory therapies encompass both antimicrobials and regular anti-inflammatory drugs...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28274357/laser-and-light-based-treatments-of-acne-and-acne-scarring
#13
Macrene Alexiades
The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28265789/depigmentation-with-q-switched-nd-yag-laser-in-universal-vitiligo-a-long-term-follow-up-study-of-4%C3%A2-years
#14
Imran Majid, Saher Imran
Q-switched (QS) lasers are used for depigmentation in universal vitiligo, but there is limited data on long-term results after laser treatment. This study was conducted to assess the safety and long-term follow-up results of QS Nd:YAG laser treatment in combination with need-based topical depigmentation therapy for universal vitiligo. A retrospective study was performed on patients with universal vitiligo who had received QS Nd:YAG laser treatment from 2010 to 2013. All patients were contacted and called for follow-up...
March 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28259838/enzyme-responsive-peptide-dendrimer-gemcitabine-conjugate-as-a-controlled-release-drug-delivery-vehicle-with-enhanced-antitumor-efficacy
#15
Chengyuan Zhang, Dayi Pan, Jin Li, Jiani Hu, Ashika Bains, Nicholas Guys, Hongyan Zhu, Xiaohui Li, Kui Luo, Qiyong Gong, Zhongwei Guc
Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we developed a novel enzyme-responsive PEGylated lysine peptide dendrimer-gemcitabine conjugate (Dendrimer-GEM) based nanoparticle via the highly efficient click reaction. Owing to the glycylphenylalanylleucylglycine tetra-peptide (GFLG) as an enzyme-cleavable linker to conjugate gemcitabine (GEM), the prepared nanoparticles were able to release drug significantly faster in the tumor cellular environments, which specifically contains secreted Cathepsin B, quantifiably more than 80% GEM was released with Cathepsin B compared to the condition without Cathepsin B at 24h...
March 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28259207/polymer-decorated-gold-nanoparticles-in-nanomedicine-conjugates
#16
REVIEW
Ignác Capek
Noble metal, especially gold nanoparticles and their conjugates with biopolymers have immense potential for disease diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of noble metal nanoparticles to ligands specifically targeted to biomarkers on diseased cells allows molecular-specific imaging and detection of disease. The development of smart gold nanoparticles (AuNPs) that can deliver therapeutics at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating cancer tumors...
February 15, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28256346/past-present-and-future-of-barrett-s-oesophagus
#17
REVIEW
W K Tan, M di Pietro, R C Fitzgerald
Barrett's oesophagus is a condition which predisposes towards development of oesophageal adenocarcinoma, a highly lethal tumour which has been increasing in incidence in the Western world over the past three decades. There have been tremendous advances in the field of Barrett's oesophagus, not only in diagnostic modalities, but also in therapeutic strategies available to treat this premalignant disease. In this review, we discuss the past, present and future of Barrett's oesophagus. We describe the historical and new evolving diagnostic criteria of Barrett's oesophagus, while also comparing and contrasting the British Society of Gastroenterology guidelines, American College of Gastroenterology guidelines and International Benign Barrett's and CAncer Taskforce (BOBCAT) for Barrett's oesophagus...
February 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28255347/enhanced-blood-suspensibility-and-laser-activated-tumor-specific-drug-release-of-theranostic-mesoporous-silica-nanoparticles-by-functionalizing-with-erythrocyte-membranes
#18
Jinghan Su, Huiping Sun, Qingshuo Meng, Pengcheng Zhang, Qi Yin, Yaping Li
Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery with a high loading capacity. However, easy aggregation in saline buffers and limited blood circulation lifetime hinder their delivery efficiency and the anticancer efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC)-mimetic theranostic nanoparticles with long blood circulation, deep-red light-activated tumor imaging and drug release were reported...
2017: Theranostics
https://www.readbyqxmd.com/read/28248076/multifunctional-theranostic-agent-of-cu2-oh-po4-quantum-dots-for-photoacoustic-image-guided-photothermal-photodynamic-combination-cancer-therapy
#19
Wei Guo, Zhenyu Qiu, Chongshen Guo, Dandan Ding, Tianchan Li, Fei Wang, Jianzhe Sun, Nannan Zheng, Shaoqin Liu
Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu2(OH)PO4 quantum dots [denoted as Cu2(OH)PO4@PAA QDs], which exhibit a strong near-infrared photoabsorption ability...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28244648/salvianolic-acid-b-regulates-gene-expression-and-promotes-cell-viability-in-chondrocytes
#20
Xiaohong Yang, Shaojie Liu, Siming Li, Pengzhen Wang, Weicong Zhu, Peihong Liang, Jianrong Tan, Shuliang Cui
Articular chondrocytes reside in lacunae distributed in cartilage responsible for the remodelling of the tissue with limited ability of damage repairing. The in vitro expanded chondrocytes enhanced by factors/agents to obtain large numbers of cells with strengthened phenotype are essential for successful repair of cartilage lesions by clinical cell implantation therapies. Because the salvianolic acid B (Sal B), a major hydrophilic therapeutic agent isolated from Salvia miltiorrhiza, has been widely used to treat diseases and able to stimulate activity of cells, this study examines the effects of Sal B on passaged chondrocytes...
February 28, 2017: Journal of Cellular and Molecular Medicine
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