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https://www.readbyqxmd.com/read/29777957/dual-ph-reduction-responsive-hybrid-polymeric-micelles-for-targeted-chemo-photothermal-combination-therapy
#1
Linhua Zhang, Yu Qin, Zhiming Zhang, Fan Fan, Chenlu Huang, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Deling Kong, Chun Wang, Hongfan Sun, Xigang Leng, Dunwan Zhu
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation...
May 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29774068/platelet-camouflaged-nanococktail-simultaneous-inhibition-of-drug-resistant-tumor-growth-and-metastasis-via-a-cancer-cells-and-tumor-vasculature-dual-targeting-strategy
#2
Lijia Jing, Haijing Qu, Dongqi Wu, Chaojian Zhu, Yongbo Yang, Xing Jin, Jian Zheng, Xiangsheng Shi, Xiufeng Yan, Yang Wang
Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy...
2018: Theranostics
https://www.readbyqxmd.com/read/29766626/co-2-laser-and-photodynamic-therapy-study-of-efficacy-in-periocular-bcc
#3
Santo Raffaele Mercuri, Pina Brianti, Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Giusy Schipani, Steven Paul Nisticò
Basal cell carcinoma (BCC), the most common type of skin cancer in the world, usually arises in sun-exposed areas of the skin. The therapeutic approach to periocular BCC has changed in the last few years. Currently the treatment, considering the delicate localization of the disease, must not only ensure complete recovery from the neoplastic disease, but must also satisfy functional and aesthetic criteria. In this study we tried to evaluate the efficacy of CO2 laser and photodynamic therapy in periocular BCC...
May 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29765174/treatment-of-retinal-capillary-hemangioma-using-810-nm-infrared-laser
#4
Pavel Pochop, Martina Kodetova, Dagmar Dotrelova
AIM: Presentation of the efficacy of infrared laser for the treatment of retinal capillary hemangioma (RCH). METHODS: The treatment and follow-up of nine eyes (fourteen tumors of different sizes and localizations) in seven patients (five children) with RCH. Infrared diode laser (810 nm) was used for modified transpupillary thermotherapy (TTT) in long exposition mode and power between 200 and 1200 mW with a beam diameter of 2 mm (indirect ophthalmoscope, +28 D or +40 D lens) or 0...
May 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29764213/a-novel-non-invasive-strategy-for-low-level-laser-induced-cancer-therapy-by-using-new-ag-zno-and-nd-zno-functionalized-reduced-graphene-oxide-nanocomposites
#5
Saeed Jafarirad, Ebrahim Hammami Torghabe, Seyed Hosseyn Rasta, Roya Salehi
In the present research, an effective drug-free approach was developed to kill MCF7 breast cancer cells using low-level laser therapy (LLLT) combined with reduced graphene oxide (rGO)-based hybrid nanocomposites (NCs). Here, fruit extract of Rosa canina was used for the first time to obtain the rGO/ZnO, Ag-ZnO/rGO and Nd-ZnO/rGO NCs by green synthesis. Physico/photochemical properties of these NCs were evaluated using FTIR, XRD, Raman, XPS, SEM/EDX, UV-Vis, DLS and AFM. The potential of the as-synthesized NCs on ROS generating and antioxidant activity were assessed by DPPH...
May 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29745953/targeted-polypyrrole-nanoparticles-for-the-identification-and-treatment-of-hepatocellular-carcinoma
#6
Yushen Jin, Xin Yang, Jie Tian
Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29745229/water-dispersible-prussian-blue-hyaluronic-acid-nanocubes-with-near-infrared-photoinduced-singlet-oxygen-production-and-photothermal-activities-for-cancer-theranostics
#7
Bo Zhou, Bang-Ping Jiang, Wanying Sun, Fang-Mian Wei, Yun He, Hong Liang, Xing-Can Shen
Design and the development of photosensitizers that can efficiently energy conversion of near infrared (NIR) laser irradiation are of major importance for cancer photoassisted therapeutics. Herein, we demonstrate for the first time that Prussian blue (PB), a classic coordination compound can act as a novel photosensitizer with efficient generation of 1O2 and excellent photothermal conversion via a NIR photo irradiation-induced energy-transfer. After modification with hyaluronic acid (HA), the as-prepared HA-modified PB nanocubes (HA@PB) are highly dispersible in aqueous and physiological solutions, as well as shows excellent photothermal/phodynamic activities under NIR (808 nm) photoexcitation...
May 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29743446/photodynamic-therapy-using-talaporfin-sodium-induces-heme-oxygenase-1-expression-in-rat-malignant-meningioma-kmy-j-cells
#8
Tsutomu Takahashi, Saki Suzuki, Suzuka Misawa, Jiro Akimoto, Yo Shinoda, Yasuyuki Fujiwara
Photodynamic therapy (PDT) using talaporfin sodium (TS) is tumor cell-selective less invasive therapy for the treatment of malignant glioma. We previously demonstrated that PDT using TS (TS-PDT) treatment exhibits anti-tumor activity against not only glioblastoma cells but also malignant meningioma cells. In general, various stress response proteins have been reported to affect the sensitivity determination for anticancer agents against tumor cells. However, the relationship between the therapeutic effect of TS-PDT and stress response systems in tumor cells is not adequately investigated...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29742720/sacral-epiduroscopic-laser-decompression-for-complex-regional-pain-syndrome-after-lumbar-spinal-surgery-a-case-report
#9
Jae-Wook Jung, Yong Han Kim, Hyojoong Kim, Eunsu Kang, Hyunji Jo, Myoung Jin Ko
RATIONALE: CRPS after a lumbar surgery has symptoms that are similar to PSSS. However, standard criteria for distinguishing CRPS from PSSS do not exist. We present a case report of a 31-year-old female with CRPS symptoms after lumbar spinal surgery treated by performing SELD. PATIENT CONCERNS: This patient was referred to our pain clinic for left ankle pain. She received a lumbar discectomy for a herniated lumbar disc (L5/S1) but the pain was aggravated after surgery...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29737836/intelligent-mno2-cu2-xs-for-multimode-imaging-diagnostic-and-advanced-single-laser-irradiated-photothermal-photodynamic-therapy
#10
Yu Cao, Xiangdan Meng, Dongdong Wang, Kai Zhang, Wenhao Dai, HaiFeng Dong, Xueji Zhang
Lately, photothermal therapy (PTT) and photodynamic therapy (PDT) dual-modal therapy has attracted much attention in cancer therapy as a synergistic therapeutic model. However, the integration of PDT and PTT in single nanoagent for cancer therapy is still a challenging task. Herein, an intelligent MnO2/Cu2-xS-siRNA nanoagent simultaneously overcoming inherent limitations of PDT and PTT with remarkable PTT/PDT therapeutic efficiency enabling multimode accurate tumor imaging diagnostic is designed. We first develop a general method to decorate Cu2-xS on the surface of MnO2 nanosheet (MnO2/Cu2-xS), then, it was loaded with heat shock protein (HSP) 70 siRNA to obtain MnO2/Cu2-xS-siRNA...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29737215/needle-free-cutaneous-delivery-of-living-human-cells-by-er-yag-fractional-laser-ablation
#11
Jing Yu, Sachin Dubey, Yogeshvar N Kalia
BACKGROUND: Dermatological diseases, including most skin cancers and rare genetic conditions frequently originate in the epidermis. Targeted, topical cell-based therapy is a promising therapeutic strategy. Here, we present the first report demonstrating that fractional laser ablation enables local "needle-free" intraepidermal delivery of living human cells. METHODS: The cells penetrated porcine ear skin via microchannels created by Er:YAG fractional laser ablation; cell delivery was quantified using a haemocytometer...
May 8, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29736759/in-vitro-impact-of-laser-irradiation-on-platelet-aggregation
#12
Eman A Shakir, Nabaa A Rasheed Naji
The review of blood optical and rheological parameters plays an important role in many medical routine diagnosis and therapeutic applications and is the best way to understand the mechanism of action of low-level laser irradiation on biological tissues. The aim of this study was to investigate the in vitro effect of laser radiation on platelet count and aggregation. Blood samples were obtained from 30 healthy volunteers; each sample was divided into four aliquots, one of them was considered as a control while the other three were exposed to three different laser doses...
May 7, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29733578/erythrocyte-membrane-modified-janus-polymeric-motors-for-thrombus-therapy
#13
Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S Williams, Jan C M van Hest
We report the construction of erythrocyte membrane-cloaked Janus polymeric motors (EM-JPMs) which are propelled by near infrared laser (NIR) irradiation, and which are successfully applied in thrombus ablation. Chitosan (a natural polysaccharide with positive charge, CHI) and heparin (glycosaminoglycan with negative charge, Hep) were selected as wall materials to construct biodegradable and biocompatible capsules through the layer-by-layer (LbL) self-assembly technique. By partially coating the capsule with a gold (Au) layer through sputter coating, a NIR-responsive Janus structure was obtained...
May 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29733117/incorporation-of-photobiomodulation-therapy-into-a-therapeutic-exercise-program-for-knee-osteoarthritis-a-placebo-controlled-randomized-clinical-trial
#14
Cid A F de Paula Gomes, Ernesto C P Leal-Junior, Almir V Dibai-Filho, Adriano R de Oliveira, André S Bley, Daniela A Biasotto-Gonzalez, Paulo de Tarso Camillo de Carvalho
OBJECTIVE: To investigate the clinical effects of incorporation of phototherapy in a therapeutic exercise program for individuals with knee osteoarthritis (OA) when compared to a group that received exercise alone and to a group that received exercise + placebo phototherapy. MATERIALS AND METHODS: This is a randomized, blinded and placebo-controlled trial. Thus, sixty male and female individuals aged 40-80 years with knee pain in the previous 6 months participated of the study, with diagnosis of unilateral knee OA based on the criteria established by the American College of Rheumatology and radiographic confirmation and Grades 2 or 3 of the Kellgren-Lawrence Classification...
May 7, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29730821/evaluation-of-the-low-level-laser-therapy-application-parameters-for-skin-burn-treatment-in-experimental-model-a-systematic-review
#15
Patricia Brassolatti, Ana Laura Martins de Andrade, Paulo Sérgio Bossini, Albaiza Nicoletti Otterço, Nivaldo Antônio Parizotto
Burn is defined as a traumatic injury of thermal origin, which affects the organic tissue. Low-level laser therapy (LLLT) has gained great prominence as a treatment in this type of injury; however, the application parameters are still controversial in the literature. The aims of this study were to review the literature studies that use LLLT as a treatment in burns conducted in an experimental model, discuss the main parameters used, and highlight the benefits found in order to choose an appropriate therapeutic window to be applied in this type of injury...
May 5, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29727164/all-in-one-theranostic-nanoagent-with-enhanced-reactive-oxygen-species-generation-and-modulating-tumor-microenvironment-ability-for-effective-tumor-eradication
#16
Yang Liu, Wenyao Zhen, Longhai Jin, Songtao Zhang, Guoying Sun, Tianqi Zhang, Xia Xu, Shuyan Song, Yinghui Wang, Jianhua Liu, Hongjie Zhang
Despite regulation of the reactive oxygen species (ROS) level is an intelligent strategy for cancer therapy, the therapeutic effects of ROS-mediated therapy (including photodynamic therapy (PDT) and chemodynamic therapy (CDT)) are limited by oxygen reliance, inherent flaws of traditional photosensitizers and strict reaction conditions of effective Fenton reaction. Herein, we reported biocompatible copper ferrite nanospheres (CFNs) with enhanced ROS production under irradiation with 650 nm laser through direct electron transfer and photo-enhanced Fenton reaction and high photothermal conversion efficiency upon exposure to 808 nm laser, exhibiting a considerable improved synergistic treatment effect...
May 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29726735/therapeutic-strategies-for-pigmented-purpuric-dermatoses-a-systematic-literature-review
#17
Kerasia-Maria Plachouri, Vaia Florou, Sophia Georgiou
Background of the article: Pigmented purpuric dermatoses (PPDs) is a group of diseases with distinguishing clinical characteristics, characterized mainly by purpuric skin lesions. The course of PPDs is chronic and recurrences are common. Although PPDs are considered to be benign, the associated symptoms, such as pruritus, and their cosmetic effect can be extremely distressing to patients. So far no evidence-based treatment has been found to be drastically effective in a large scale of patients. MATERIALS AND METHODS: This paper is a systematic overview of all the reported successful treatments described in the literature...
May 4, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29722425/comparative-study-of-the-bactericidal-effects-of-indocyanine-green-and-methyl-aminolevulinate-based-photodynamic-therapy-on-propionibacterium-acnes-as-a-new-treatment-for-acne
#18
Seung-Hwan Choi, Jeong-Wan Seo, Ki-Ho Kim
Acne vulgaris is one of the most common dermatological problems, and its therapeutic options include topical and systemic retinoids and antibiotics. However, increase in problems associated with acne treatment, such as side-effects from conventional agents and bacterial resistance to antibiotics, has led to greater use of photodynamic therapy. The purpose of this study was to compare the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes...
May 3, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29722183/near-infrared-low-level-laser-therapy-and-cell-proliferation-the-emerging-role-of-redox-sensitive-signal-transduction-pathways
#19
REVIEW
Mario Migliario, Maurizio Sabbatini, Carmen Mortellaro, Filippo Renò
Lasers devices are widely used in various medical fields (e.g. surgery, dermatology, dentistry, rehabilitative medicine, etc) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect...
May 2, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29718060/platinum-nanoparticles-a-non-toxic-effective-and-thermally-stable-alternative-plasmonic-material-for-cancer-therapy-and-bioengineering
#20
Akbar Samadi, Henrik Klingberg, Liselotte Jauffred, Andreas Kjær, Poul Martin Bendix, Lene B Oddershede
Absorption of near infrared (NIR) light by metallic nanoparticles can cause extreme heating and is of interest for instance in cancer treatment since NIR light has a relatively large penetration depth into biological tissue. Here, we quantify the extraordinary thermoplasmonic properties of platinum nanoparticles and demonstrate their efficiency in photothermal cancer therapy. Although platinum nanoparticles are extensively used for catalysis, they are much overlooked in a biological context. Via direct measurements based on a biological matrix we show that individual irradiated platinum nanoparticles with diameters of 50-70 nm can easily reach surface temperatures up to 900 K...
May 2, 2018: Nanoscale
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