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https://www.readbyqxmd.com/read/28914194/diabetic-retinopathy-recent-updates-on-different-biomarkers-and-some-therapeutic-agents
#1
Amjad Ali Khan, Arshad Husain Rahmani, Yousef Homood Aldebasi
BACKGROUND: Diabetic Retinopathy is a leading cause of sight-threatening complication, which occurs due to a number of physiological and metabolic abnormalities during later stages of diabetes. Many of these abnormal changes are consistent with altered oxidative stress, inflammation, genetic set up, advanced glycation end products, and hematological changes. So the altered levels of different biomolecules related to these changes serve as important biomarkers to assess better evaluation and early treatment of this disease...
September 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28906574/efficacy-and-safety-of-a-novel-picosecond-laser-using-combination-of-1%C3%A2-064-and-595%C3%A2-nm-on-patients-with-melasma-a-prospective-randomized-multicenter-split-face-2-hydroquinone-cream-controlled-clinical-trial
#2
Young-Jun Choi, Jae-Hui Nam, Jung Yup Kim, Joon Hong Min, Kui Young Park, Eun Jung Ko, Beom Joon Kim, Won-Serk Kim
BACKGROUND AND OBJECTIVES: Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone...
September 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28898420/characterization-of-hyperbranched-core-multishell-nanocarriers-as-an-innovative-drug-delivery-system-for-the-application-at-the-oral-mucosa
#3
J Jager, K Obst, S B Lohan, J Viktorov, S Staufenbiel, H Renz, M Unbehauen, R Haag, S Hedtrich, C Teutloff, M C Meinke, K Danker, H Dommisch
BACKGROUND AND OBJECTIVES: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Dilution effects due to saliva hinder the adherence and the penetration of drug formulations. Therefore, the bioavailability of oral topical drugs is insufficient, and patients may suffer from disease over years, if not life-long...
September 12, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28895715/a-pompon-like-runps-based-theranostic-nanocarrier-system-with-stable-photoacoustic-imaging-characteristic-for-accurate-tumor-detection-and-efficient-phototherapy-guidance
#4
Gengjia Chen, Meng Xu, Shuang Zhao, Jing Sun, Qianqian Yu, Jie Liu
Even though numerous therapeutic methods exist for cancer treatment, many fail to achieve ideal outcomes or have severe side effects. Here, we describe a theranostic nanocarrier system with improved tumor vasculature detection and tumor margin quantification that increases the accuracy and guidance efficiency of phototherapy. Novel pompon-like RuNPs with superb photothermal properties and high encapsulation efficiency were first synthesized via the polyol reducing method. Based on these RuNPs, we then developed a multifunctional theranostic system, pRu-pNIPAM@RBT, composed of poly(Nisopropylacrylamide) as the thermal-response switch and of [Ru(bpy)2(tip)]2+ as the photosensitizer of PDT and the contrast agent of biomedical imaging...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28892645/self-assembling-peptide-p11-4-and-fluoride-for-regenerating-enamel
#5
M Alkilzy, A Tarabaih, R M Santamaria, C H Splieth
Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimal invasive therapy. In vitro, self-assembling peptide P11-4 enhances remineralization of early carious lesions. To investigate the safety and clinical efficacy of P11-4 for treatment of initial caries, a randomized controlled single-blind study was conducted on children aged >5 y with visible active early caries on erupting permanent molars. Subjects were randomized to either the test group (P11-4 + fluoride varnish) or control group (fluoride varnish alone)...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28887783/a-novel-integration-of-spectral-domain-optical-coherence-tomography-and-laser-ablation-system-for-precision-treatment
#6
Yingwei Fan, Boyu Zhang, Wei Chang, Xinran Zhang, Hongen Liao
PURPOSE: Complete resection of diseased lesions reduces the recurrence of cancer, making it critical for surgical treatment. However, precisely resecting residual tumors is a challenge during operation. A novel integrated spectral-domain optical-coherence-tomography (SD-OCT) and laser-ablation therapy system for soft-biological-tissue resection is proposed. This is a prototype optical integrated diagnosis and therapeutic system as well as an optical theranostics system. METHODS: We develop an optical theranostics system, which integrates SD-OCT, a laser-ablation unit, and an automatic scanning platform...
September 9, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28880961/experimental-verification-of-subthreshold-laser-therapy-using-conventional-pattern-scan-laser
#7
Tomoyasu Shiraya, Satoshi Kato, Fumiyuki Araki, Takashi Ueta, Hitoshi Abe, Nobuharu Asai
PURPOSE: Leading-edge therapeutic laser technologies are not available at every medical facility; therefore, alternative approaches incorporating novel advances in digital and laser technology into more readily available conventional methods have generated significant research interest. Using a rabbit model, this study investigated whether the algorithm used in the Endpoint Management (EM) software system of the latest devices could enable subthreshold laser treatment in conventional retinal tissue laser therapy systems...
2017: PloS One
https://www.readbyqxmd.com/read/28875691/construction-and-evaluation-of-a-targeted-hyaluronic-acid-nanoparticle-photosensitizer-complex-for-cancer-photodynamic-therapy
#8
Shi Gao, Jingjing Wang, Rui Tian, Guohao Wang, Liwen Zhang, Yesen Li, Lu Li, Qingjie Ma, Lei Zhu
Photodynamic therapy (PDT) is a novel treatment modality that is under intensive preclinical investigations for a variety of diseases, including cancer. Despite extensive studies in this area, selective and effective photodynamic agents that can specifically accumulate in tumors to reach a therapeutic concentration are limited. Although recent attempts have produced photosensitizers (PSs) complexed with various nanomaterials, the tedious preparation steps and poor tumor efficiency of therapy hamper their utilization...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#9
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28866175/near-infrared-radiated-stimulus-responsive-liposomes-based-on-photothermal-conversion-as-drug-carriers-for-co-delivery-of-cjm126-and-cisplatin
#10
Chaoqun You, Mingxin Wang, Hongshuai Wu, Peijing An, Mengmeng Pan, Yanghui Luo, Baiwang Sun
Synergistic therapy has caused increasing interest in recent treatment of cancer owing to its preferable therapeutic efficiency to most single antineoplastic protocol. Herein, we design a co-delivery two drugs nanosystem based on biodegradable liposomes, loading cisplatin, Indocyanine green (ICG), and CJM126 coupled with cholesterol derivative (CJM-Chol) for the purpose of synergistic therapy. The obtained nanoparticles showed a uniform diameter of 103.8nm and a favorable morphology. The investigation on near infrared radiated (NIR) responsive release showed that NIR mediated photothermal conversion induced a controllable drug release from liposomes...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866143/construction-of-icg-encapsulated-w18o49-msn-as-a-fluorescence-carrier-for-real-time-tracked-photothermal-therapy
#11
Hui-Quan Wang, Peng-Fei Hu, Yu Zheng, Zhe Zhao, Bin Zheng, Jin Chang, Han-Jie Wang, Jin-Hai Wang
Photothermal therapy (PTT) has drawn tremendous attention because of its high therapeutic efficiency in targeting cells while minimizing the damage to normal tissues and organs. Tungsten oxide (W18O49, WO) plays a pivotal role in PTT development and its use in PTT systems has been extensively studied. However, it is difficult to control morphology of WO through conventional hydrothermal method. Which make its related researches have been limited up to now. In this study, we describe the construction and effects on tumor of a novel nanoplatform based on WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticles (MSN) for dual-modal PTT and near-infrared imaging...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28864923/evaluation-of-carbon-dioxide-laser-therapy-for-benign-tumors-of-the-eyelid-margin
#12
Aniko Rentka, Jan Grygar, Zoltan Nemes, Adam Kemeny-Beke
Eyelid margin tumors require special attention based on both anatomical and histological perspectives. Our aim in this study was to evaluate carbon dioxide (CO2) laser therapy for the treatment of eyelid margin tumors. Fifty-two patients with 55 eyelid margin tumors were included in this study. All tumors were removed with a CO2 laser, and histopathological evaluation was obtained in 52 cases. All patients were followed up for a mean period of 8.5 months (range 6 to 14 months). There were no bleedings in the intra- and postoperative period; the wounds were dry and reepithelized after 10-14 days and no recurrence occurred during follow-up period...
September 2, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28852616/synthesis-and-optimization-of-mos2-fe3o4-icg-pt-iv-nanoflowers-for-mr-ir-pa-bioimaging-and-combined-ptt-pdt-chemotherapy-triggered-by-808-nm-laser
#13
Bei Liu, Chunxia Li, Guanying Chen, Bin Liu, Xiaoran Deng, Yi Wei, Jun Xia, Bengang Xing, Ping'an Ma, Jun Lin
Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80-180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS2@Fe3O4-ICG/Pt(IV) (labeled as Mo@Fe-ICG/Pt) is designed by covalently grafting Fe3O4 nanoparticles with polyethylenimine (PEI) functionalized MoS2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS2@Fe3O4...
August 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28843922/gold-nanoparticle-gated-mesoporous-silica-as-redox-triggered-drug-delivery-for-chemo-photothermal-synergistic-therapy
#14
Yang Yang, Yuanzhe Lin, Donghua Di, Xing Zhang, Da Wang, Qinfu Zhao, Siling Wang
In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au...
August 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28841279/regulating-near-infrared-photodynamic-properties-of-semiconducting-polymer-nanotheranostics-for-optimized-cancer-therapy
#15
Houjuan Zhu, Yuan Fang, Qingqing Miao, Xiaoying Qi, Dan Ding, Peng Chen, Kanyi Pu
Development of optical nanotheranostics for the capability of photodynamic therapy (PDT) provides opportunities for advanced cancer therapy. However, most nanotheranostic systems fail to regulate their generation levels of reactive oxygen species (ROS) according to the disease microenvironment, which can potentially limit their therapeutic selectivity and increase the risk of damage to normal tissues. We herein report the development of hybrid semiconducting polymer nanoparticles (SPNs) with self-regulated near-infrared (NIR) photodynamic properties for optimized cancer therapy...
August 30, 2017: ACS Nano
https://www.readbyqxmd.com/read/28839462/albumin-gold-nanorod-nanoplatform-for-cell-mediated-tumoritropic-delivery-with-homogenous-chemodrug-distribution-and-enhanced-retention-ability
#16
Hsien-Ting Chiu, Cheng-Kuan Su, Yuh-Chang Sun, Chi-Shiun Chiang, Yu-Fen Huang
Recently, living cells with tumor-homing properties have provided an exciting opportunity to achieve optimal delivery of nanotherapeutic agents. However, premature payload leakage may impair the host cells, often leading to inadequate in vivo investigations or therapeutic efficacy. Therefore, a nanoplatform that provides a high drug-loading capacity and the precise control of drug release is required. In the present study, a robust one-step synthesis of a doxorubicin (DOX)-loaded gold nanorod/albumin core-shell nanoplatform (NR@DOX:SA) was designed for effective macrophage-mediated delivery to demonstrate how nanoparticle-loaded macrophages improve photothermal/chemodrug distribution and retention ability to achieve enhanced antitumor effects...
2017: Theranostics
https://www.readbyqxmd.com/read/28838759/chitosan-based-mucoadhesive-gel-for-oral-mucosal-toluidine-blue-o-delivery-the-influence-of-a-non-ionic-surfactant
#17
Maria Teresa Junqueira Garcia, Cristhiane de Paula Freitas, Thierllen Barroso Graciano, Tatielle Soares Coutinho, Camila Beatriz Cressoni, Sanívia Aparecida de Lima Pereira, Marcos Massao Shimano
Photodynamic therapy (PDT) has been successfully employed in the treatment of oral cancer. Toluidine blue O (TBO) is a photosensitizer (PS) that has exhibited remarkable photocytotoxicity in a variety of tumour cells; however, its physicochemical properties, as well as the physicochemical properties of oral mucosa, prevent the drug from reaching the target site at a therapeutic concentration. The aim of this study was to evaluate the influence of Tween 80(®) (TW), which has shown potential as a penetration enhancer, on the mucosal retention of TBO for the PDT of oral cancer...
August 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28836528/low-level-laser-therapy-a-novel-therapeutic-approach-to-temporomandibular-disorder-a-randomized-double-blinded-placebo-controlled-trial
#18
R Shobha, Veena S Narayanan, B S Jagadish Pai, H P Jaishankar, M J Jijin
AIMS AND OBJECTIVE: The objective of this study was to assess the effectiveness of low-level laser therapy (LLLT)/low intensity laser therapy (LILT) in the management of temporomandibular joint (TMJ) pain in a random and double-blind research design. MATERIALS AND METHODS: TMJ pain patients, randomly assigned into two groups: Group 1 (n = 20) and Group 2 (n = 20), received 2-3 treatments per week for 8 sessions of active LILT with diode laser (gallium aluminum arsenide, 810 nm, 0...
July 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28834821/therapeutic-femtosecond-laser-assisted-lamellar-keratectomy-for-multidrug-resistant-nocardia-keratitis
#19
Parth Shah, Dagny Zhu, William W Culbertson
PURPOSE: To describe the novel use of femtosecond laser technology for therapeutic resection of infectious foci in a case of multidrug-resistant Nocardia asteroides keratitis. METHODS: A 30-year-old man presented with a corneal infiltrate. Cultures were taken, and fortified vancomycin and tobramycin were initiated. After 3 negative cultures and minimal improvement on various broad-spectrum antibiotics, all topical medications were stopped and a final fourth corneal culture grew N...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28833900/treatment-of-oral-lichen-planus-using-308-nm-excimer-laser
#20
Wei-Bing Liu, Li-Wei Sun, Hua Yang, Yan-Fei Wang
Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereby cannot be used in the treatment of OLP. Lymphocytic infiltration is evident in the lesions of lichen planus, and the direct irradiation of 308-nm excimer laser can induce apoptosis of the T lymphocytes in skin lesions, thereby has a unique therapeutic effect on the diseases involving T lymphocytes...
August 23, 2017: Dermatologic Therapy
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