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https://www.readbyqxmd.com/read/28789843/the-thirsty-dropsy-early-descriptions-in-medical-and-non-medical-authors-of-thirst-as-symptom-of-chronic-heart-failure
#1
M A Riva, F Cesana, F Achilli, F Scordo, G Cesana
BACKGROUND: Patients with chronic heart failure may suffer from severe thirst, even if mechanisms that cause thirst in subjects affected by this condition are not clear. Medical and non-medical authors may have already recognized this symptom during the classical age. METHODS: We analyzed association between thirst and dropsy (an ancient medical term used to indicate different conditions including chronic heart failure) in past medical and non-medical literature...
August 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28680070/whole-mitogenomes-reveal-the-history-of-swamp-buffalo-initially-shaped-by-glacial-periods-and-eventually-modelled-by-domestication
#2
S Wang, N Chen, M R Capodiferro, T Zhang, H Lancioni, H Zhang, Y Miao, V Chanthakhoun, M Wanapat, M Yindee, Y Zhang, H Lu, L Caporali, R Dang, Y Huang, X Lan, M Plath, H Chen, J A Lenstra, A Achilli, C Lei
The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp-buffalo mitogenome is dated ~232 ± 35 Kya. Two major macro-lineages diverged during the 2(nd) Pleistocene Glacial Period (~200-130 Kya), but most (~99%) of the current matrilines derive from only two ancestors (SA1'2 and SB) that lived around the Last Glacial Maximum (~26-19 Kya)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28668965/membrane-remodelling-and-vesicle-formation-during-ageing-of-human-red-blood-cells
#3
Annarita Ciana, Cesare Achilli, Anjali Gaur, Giampaolo Minetti
BACKGROUND/AIMS: A high surface-to-volume ratio and a spectrin membrane-skeleton (MS) confer to the mammalian red blood cells (RBCs) their characteristic deformability, mechanical strength and structural stability. During their 120 days of circulatory life in humans, RBCs decrease in size, while remaining biconcave disks, owing to a coordinated decrease in membrane surface area and cell water. It is generally believed that part of the membrane is lost with the shedding of spectrin-free vesicles of the same type that can be obtained in vitro by different treatments...
June 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28668958/spectrin-and-other-membrane-skeletal-components-in-human-red-blood-cells-of-different-age
#4
Annarita Ciana, Cesare Achilli, Giampaolo Minetti
BACKGROUND: Old human red blood cells (RBCs) have a reduced surface area with respect to young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin-free vesicles that are shed in vitro under different experimental conditions or during storage, there would be no decrease of membrane-skeleton, but only of lipid bilayer surface area, during RBC ageing in vivo. However, we observed a decrease in spectrin and other membrane-skeletal proteins in old RBCs. Because RBCs contain components of the ubiquitin-proteasome system and other hydrolytic systems for protein degradation, we asked whether increased membrane-skeleton fragments could be detected in older RBCs...
June 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28619004/albumin-nanocarriers-%C3%AE-irradiated-crosslinked-combined-with-therapeutic-drugs-for-cancer-therapy
#5
Macarena Siri, Estefanía Achilli, Mariano Grasselli, Silvia Del V Alonso
Albumin polymeric Nanoparticles (NPs) have opened a great expectancy as for controlled drug delivery due to their therapeutic potency. Concomitantly biodegradable NPs technologies with target linked structures to pave the way of personalised medicine are becoming increasingly important in sight of a therapeutically effective research technology. This is particularly attractive for nanoparticle-based cancer delivery systems, based on the known limitations and efforts to overcome. This new group of gamma irradiated-NPs inherited both the protein delivery properties and robustness of polymer forming structures, and gamma irradiation techniques that leave clean, innocuous and biodegradable NPs...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28558207/structure-and-stability-of-a-copper-ii-lactate-complex-in-alkaline-solution-a-case-study-by-energy-dispersive-x-ray-absorption-spectroscopy
#6
Elisabetta Achilli, Alberto Vertova, Alberto Visibile, Cristina Locatelli, Alessandro Minguzzi, Sandra Rondinini, Paolo Ghigna
Energy-dispersive X-ray absorption spectroscopy was applied, aimed at solving the problem of the structure and stability of a copper(II) lactate complex in alkaline solution, used as a precursor for the electrodeposition of Cu2O. The application of multiple scattering calculations to the simulation of the X-ray absorption near-edge structure part of the spectra allowed an accurate resolution of the structure: the copper(II) cation is surrounded by four lactate ions in a distorted tetrahedral environment, with the lactate anions acting as monodentate ligands...
May 30, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28539931/characterization-and-phylogenetic-analysis-of-ancient-italian-landraces-of-pear
#7
Nicoletta Ferradini, Hovirag Lancioni, Renzo Torricelli, Luigi Russi, Isabella Dalla Ragione, Irene Cardinali, Gianpiero Marconi, Mauro Gramaccia, Luciano Concezzi, Alessandro Achilli, Fabio Veronesi, Emidio Albertini
Pear is one of the oldest fruit tree crops and the third most important temperate fruit species. Its domestication took place independently in the Far East (China) and in the Caucasus region. While the origin of Eastern Asian cultivars is clear, that of European cultivars is still in doubt. Italy has a wealth of local varieties and genetic resources safeguarded by several public and private collections to face the erosion caused by the introduction of improved varieties in specialized orchards. The objectives of the present study were: (i) to characterize the existing germplasm through nuclear (SSR) and (ii) to clarify the genetic divergence between local and cultivated populations through chloroplast DNA (cpDNA) markers in order to provide insights into phylogenetic relationships of Pyrus spp...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28425281/hybridized-c-o-si-interface-states-at-the-origin-of-efficiency-improvement-in-cnt-si-solar-cells
#8
Stefano Ponzoni, Simona Achilli, Chiara Pintossi, Giovanni Drera, Luigi Sangaletti, Paola Castrucci, Maurizio De Crescenzi, Stefania Pagliara
Despite the astonishing values of the power conversion efficiency reached, in just less than a decade, by the carbon nanotube/silicon (CNT/Si) solar cells, many doubts remain on the underlying transport mechanisms across the CNT/Si heterojunction. Here, by combining transient optical spectroscopy in the femtosecond timescale, X-ray photoemission, and a systematic tracking of I-V curves across all phases of the interlayer SiOx growth at the interface, we grasp the mechanism that adequately preserves charge separation at the junction, hindering the photoexcited carrier recombination...
May 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28389114/facile-access-to-pseudo-thio-1-2-dimannoside-a-new-glycomimetic-dc-sign-antagonist
#9
Alice Tamburrini, Silvia Achilli, Francesca Vasile, Sara Sattin, Corinne Vivès, Cinzia Colombo, Franck Fieschi, Anna Bernardi
The synthesis and conformational analysis of pseudo-thio-1,2-dimannoside are described. This molecule mimics mannobioside (Manα(1,2)Man) and is an analog of pseudo-1,2-dimannoside, with expected increased stability to enzymatic hydrolysis. A short and efficient synthesis was developed based on an epoxide ring-opening reaction by a mannosyl thiolate, generated in situ from the corresponding thioacetate. NMR-NOESY studies supported by MM3(∗) calculations showed that the pseudo-thio-1,2-dimannoside shares the conformational behavior of the pseudo-1,2-dimannoside and is a structural mimic of the natural disaccharide...
March 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28387361/origin-and-spread-of-human-mitochondrial-dna-haplogroup-u7
#10
Hovhannes Sahakyan, Baharak Hooshiar Kashani, Rakesh Tamang, Alena Kushniarevich, Amirtharaj Francis, Marta D Costa, Ajai Kumar Pathak, Zaruhi Khachatryan, Indu Sharma, Mannis van Oven, Jüri Parik, Hrant Hovhannisyan, Ene Metspalu, Erwan Pennarun, Monika Karmin, Erika Tamm, Kristiina Tambets, Ardeshir Bahmanimehr, Tuuli Reisberg, Maere Reidla, Alessandro Achilli, Anna Olivieri, Francesca Gandini, Ugo A Perego, Nadia Al-Zahery, Massoud Houshmand, Mohammad Hossein Sanati, Pedro Soares, Ekta Rai, Jelena Šarac, Tena Šarić, Varun Sharma, Luisa Pereira, Veronica Fernandes, Viktor Černý, Shirin Farjadian, Deepankar Pratap Singh, Hülya Azakli, Duran Üstek, Natalia Ekomasova Trofimova, Ildus Kutuev, Sergei Litvinov, Marina Bermisheva, Elza K Khusnutdinova, Niraj Rai, Manvendra Singh, Vijay Kumar Singh, Alla G Reddy, Helle-Viivi Tolk, Svjetlana Cvjetan, Lovorka Barac Lauc, Pavao Rudan, Emmanuel N Michalodimitrakis, Nicholas P Anagnou, Kalliopi I Pappa, Maria V Golubenko, Vladimir Orekhov, Svetlana A Borinskaya, Katrin Kaldma, Monica A Schauer, Maya Simionescu, Vladislava Gusar, Elena Grechanina, Periyasamy Govindaraj, Mikhail Voevoda, Larissa Damba, Swarkar Sharma, Lalji Singh, Ornella Semino, Doron M Behar, Levon Yepiskoposyan, Martin B Richards, Mait Metspalu, Toomas Kivisild, Kumarasamy Thangaraj, Phillip Endicott, Gyaneshwer Chaubey, Antonio Torroni, Richard Villems
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377518/ancient-individuals-from-the-north-american-northwest-coast-reveal-10-000-years-of-regional-genetic-continuity
#11
John Lindo, Alessandro Achilli, Ugo A Perego, David Archer, Cristina Valdiosera, Barbara Petzelt, Joycelynn Mitchell, Rosita Worl, E James Dixon, Terence E Fifield, Morten Rasmussen, Eske Willerslev, Jerome S Cybulski, Brian M Kemp, Michael DeGiorgio, Ripan S Malhi
Recent genomic studies of both ancient and modern indigenous people of the Americas have shed light on the demographic processes involved during the first peopling. The Pacific Northwest Coast proves an intriguing focus for these studies because of its association with coastal migration models and genetic ancestral patterns that are difficult to reconcile with modern DNA alone. Here, we report the low-coverage genome sequence of an ancient individual known as "Shuká Káa" ("Man Ahead of Us") recovered from the On Your Knees Cave (OYKC) in southeastern Alaska (archaeological site 49-PET-408)...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28230223/observation-of-charge-transfer-cascades-in-%C3%AE-fe2o3-irox-photoanodes-by-operando-x-ray-absorption-spectroscopy
#12
Alessandro Minguzzi, Alberto Naldoni, Ottavio Lugaresi, Elisabetta Achilli, Francesco D'Acapito, Francesco Malara, Cristina Locatelli, Alberto Vertova, Sandra Rondinini, Paolo Ghigna
Electrochemical devices for energy conversion and storage are central for a sustainable economy. The performance of electrodes is driven by charge transfer across different layer materials and an understanding of the mechanistics is pivotal to gain improved efficiency. Here, we directly observe the transfer of photogenerated charge carriers in a photoanode made of hematite (α-Fe2O3) and a hydrous iridium oxide (IrOx) overlayer, which plays a key role in photoelectrochemical water oxidation. Through the use of operando X-ray absorption spectroscopy (XAS), we probe the change in occupancy of the Ir 5d levels during optical band gap excitation of α-Fe2O3...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28199423/-outpatient-s-profile-assisted-by-the-psychiatry-residents-of-the-prof-dr-r-rossi-general-hospital-la-plata-argentina
#13
Diego Giannandrea, Julián Achilli Lucas, Lucía Saldaño, María J Barrenengoa, Mariano Dramis, Mariano Barraco, Matías González Olivi, María T Burry
OBJECTIVE: To define the profile and the treatments evolution of the outpatients assisted by the psychiatry residents of the Rossi Hospital in La Plata. METHODS: It was analyzed the period between 2005 and 2010 (six years). The variables selected included gender, age, diagnosis (according to ICD 10), duration and evolution of treatment. RESULTS: From the total number of patients (n=341), 58,7% were women (n= 200) and 41,3% men (n= 141). The most frequent diagnoses were: anxiety disorders (13,6%), depressive disorders (12,8%), schizophrenia (12,2%), other non-affective psychoses (9%) and mental retardation (8,4%)...
March 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28177087/mitogenome-diversity-in-sardinians-a-genetic-window-onto-an-island-s-past
#14
Anna Olivieri, Carlo Sidore, Alessandro Achilli, Andrea Angius, Cosimo Posth, Anja Furtwängler, Stefania Brandini, Marco Rosario Capodiferro, Francesca Gandini, Magdalena Zoledziewska, Maristella Pitzalis, Andrea Maschio, Fabio Busonero, Luca Lai, Robin Skeates, Maria Giuseppina Gradoli, Jessica Beckett, Michele Marongiu, Vittorio Mazzarello, Patrizia Marongiu, Salvatore Rubino, Teresa Rito, Vincent Macaulay, Ornella Semino, Maria Pala, Gonçalo R Abecasis, David Schlessinger, Eduardo Conde-Sousa, Pedro Soares, Martin B Richards, Francesco Cucca, Antonio Torroni
Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate...
May 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28018850/right-ventricular-reverse-remodelling-in-idiopathic-pulmonary-arterial-hypertension-diagnosed-during-pregnancy-is-it-possible
#15
Giuseppe Paciocco, Andrea Lombi, Antonella Vincenzi, Alberto Pesci, Felice Achilli
We present a case of a 36-year-old woman who developed a severe form of Idiopathic Pulmonary Arterial Hypertension (IPAH) during pregnancy and after emergency delivery. The management of IPAH during or after pregnancy is complex. Due to the severity of her IPAH, an upfront triple combination therapy, including i.v. epoprostenol, was started. The rapid institution of this treatment regimen allowed a complete right ventricular reverse remodelling after 1 year of therapy, leading to a down-titration until complete suspension of epoprostenol from the treatment regimen...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27982607/tognolini-et%C3%A2-al-reply
#16
S Tognolini, S Achilli, L Longetti, E Fava, C Mariani, M I Trioni, S Pagliara
No abstract text is available yet for this article.
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27974499/human-sod1-als-mutations-in-a-drosophila-knock-in-model-cause-severe-phenotypes-and-reveal-dosage-sensitive-gain-and-loss-of-function-components
#17
Aslı Şahin, Aaron Held, Kirsten Bredvik, Paxton Major, Toni-Marie Achilli, Abigail G Kerson, Kristi Wharton, Geoff Stilwell, Robert Reenan
Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset motor neuron disease and familial forms can be caused by numerous dominant mutations of the copper-zinc superoxide dismutase 1 (SOD1) gene. Substantial efforts have been invested in studying SOD1-ALS transgenic animal models; yet, the molecular mechanisms by which ALS-mutant SOD1 protein acquires toxicity are not well understood. ALS-like phenotypes in animal models are highly dependent on transgene dosage. Thus, issues of whether the ALS-like phenotypes of these models stem from overexpression of mutant alleles or from aspects of the SOD1 mutation itself are not easily deconvolved...
February 2017: Genetics
https://www.readbyqxmd.com/read/27933090/the-worldwide-spread-of-the-tiger-mosquito-as-revealed-by-mitogenome-haplogroup-diversity
#18
Vincenza Battaglia, Paolo Gabrieli, Stefania Brandini, Marco R Capodiferro, Pio A Javier, Xiao-Guang Chen, Alessandro Achilli, Ornella Semino, Ludvik M Gomulski, Anna R Malacrida, Giuliano Gasperi, Antonio Torroni, Anna Olivieri
In the last 40 years, the Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the recently emerged Zika fever. To acquire more information on the ancestral source(s) of adventive populations and the overall diffusion process from its native range, we analyzed the mitogenome variation of 27 individuals from representative populations of Asia, the Americas, and Europe...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27916205/efficacy-and-safety-of-transdermal-testosterone-in-postmenopausal-women-with-hypoactive-sexual-desire-disorder-a-systematic-review-and-meta-analysis
#19
REVIEW
Chiara Achilli, Jyotsna Pundir, Parimalam Ramanathan, Luca Sabatini, Haitham Hamoda, Nick Panay
OBJECTIVE: To systematically review and summarize the existing evidence related to the efficacy and safety of transdermal T in postmenopausal women for the treatment of hypoactive sexual desire disorder (HSDD). DESIGN: Systematic reviews and meta-analysis. SETTING: Not applicable. PATIENT(S): Seven randomized controlled trials enrolled 3,035 participants; 1,350 women were randomized to treatment with T patch, and 1,379 women were randomized to placebo...
February 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27667396/textile-organic-electrochemical-transistors-as-a-platform-for-wearable-biosensors
#20
I Gualandi, M Marzocchi, A Achilli, D Cavedale, A Bonfiglio, B Fraboni
The development of wearable chemical sensors is receiving a great deal of attention in view of non-invasive and continuous monitoring of physiological parameters in healthcare applications. This paper describes the development of a fully textile, wearable chemical sensor based on an organic electrochemical transistor (OECT) entirely made of conductive polymer (PEDOT:PSS). The active polymer patterns are deposited into the fabric by screen printing processes, thus allowing the device to actually "disappear" into it...
September 26, 2016: Scientific Reports
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