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ramdomized clinical trial

H DeGroot, E Centeno-Arnuero
BACKGROUND: Randomized controlled surgical trials (RCST) are the optimal way to validate new surgical treatments, yet RCSTs comprise a very small fraction of published articles in the surgical literature. One of most frequent reasons for lack of success in RCSTs is the failure to recruit an adequate number of patients. METHODS: We report the results of 14 months of recruitment for an RCST comparing two different surgical procedures for the treatment of painful hallux valgus...
March 2015: Acta Ortopédica Mexicana
Wen-Hui Chen, Lin-Quan Tang, Shan-Shan Guo, Qiu-Yan Chen, Lu Zhang, Li-Ting Liu, Chao-Nan Qian, Xiang Guo, Dan Xie, Mu-Sheng Zeng, Hai-Qiang Mai
This study aimed to evaluate the prognostic value of plasma Epstein-Barr Virus DNA (EBV DNA) for local and regionally advanced nasopharyngeal carcinoma (NPC) patients treated with concurrent chemoradiotherapy in intensity-modulated radiotherapy (IMRT) era.In this observational study, 404 nonmetastatic local and regionally advanced NPC patients treated with IMRT and cisplatin-based concurrent chemotherapy were recruited. Blood samples were collected before treatment for examination of plasma EBV DNA levels. We evaluated the association of pretreatment plasma EBV DNA levels with progression-free survival rate (PFS), distant metastasis-free survival rate (DMFS), and overall survival rate (OS)...
February 2016: Medicine (Baltimore)
A Ramos Luengo, F Asensio Merino, M S Castilla, E Alonso Rodriguez
OBJECTIVE: Determine the best propofol pharmacokinetic model that meets patient requirements and is devoid of major haemodynamic side effects. MATERIAL AND METHODS: Prospective, randomised, open-label, clinical trial was performed on an intention to treat basis. It included 280 patients with ASA physical status i-iii, aged 18 to 80 years and weight range between 45 to 100kg, scheduled for surgery under general anaesthesia. They were randomized into 2 groups according to the pharmacokinetic model: Modified Marsh group and Schnider group...
November 2015: Revista Española de Anestesiología y Reanimación
A U Krettli, V F Andrade-Neto, M G Brandão, W M Ferrari
In this review we discuss the ongoing situation of human malaria in the Brazilian Amazon, where it is endemic causing over 610,000 new acute cases yearly, a number which is on the increase. This is partly a result of drug resistant parasites and new antimalarial drugs are urgently needed. The approaches we have used in the search of new drugs during decades are now reviewed and include ethnopharmocology, plants randomly selected, extracts or isolated substances from plants shown to be active against the blood stage parasites in our previous studies...
November 2001: Memórias do Instituto Oswaldo Cruz
(no author information available yet)
The 'Consolidation of the standards of reporting trials' (CONSORT) statement was published in 1996. From that time on all manuscripts reporting randomized controlled trials (RCTs) submitted to JAMA, The Lancet or the British Medical Journal, must include a flow diagram and all the information in the CONSORT checklist. The Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) will follow suit. The manuscripts must be accompanied by this checklist together with the page numbers where each item may be found...
May 9, 1998: Nederlands Tijdschrift Voor Geneeskunde
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