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https://www.readbyqxmd.com/read/28300892/scleromyxedema-clinical-diagnosis-and-autopsy-findings
#1
Ana Carolina Bulhões Sala, Paulo Rowilson Cunha, Clóvis Antônio Lopes Pinto, Célia Antônia Xavier de Moraes Alves, Ingrid Barreto Paiva, Ana Paula Vieira Araujo
Scleromyxedema is a rare chronic cutaneous mucinosis of unknown etiology. It is characterized by papular eruption and scleroderma with microscopic evidence of mucin deposition, fibroblast proliferation, and fibrosis. Most patients with scleromyxedema have monoclonal gammopathy and systemic manifestations resulting in significant morbidity and mortality. Several types of treatment have been reported with partial or inconsistent responses. Despite showing unpredictable evolution, systemic consequences of scleromyxedema and treatment side effects may result in death...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28294586/pediatric-eosinophilic-esophagitis-in-portugal
#2
J L Alves Marcelino, R Cardoso de Aguiar, F Cabral Duarte, A Célia Costa, M A Pereira-Barbosa
Eosinophilic esophagitis (EoE) is an increasingly frequent diagnosis in our clinical practice, mainly in pediatric age. Allergic responses to food and aeroallergens have been increasingly implicated in the etiology of this disease. We describe a retrospective data analysis of pediatric EoE patients followed in our Immunoallergology Department. Of the 25 children (22 male, average 10.8 years), 88% had prior history of rhinoconjunctivitis, 76% asthma, 48% eczema and 36% food allergy. After evaluation, we identified in 76% and 92% of patients food and aeroallergen sensitization, respectively; 68% had simultaneously food and inhalant sensitization and 96% had at least one positive test to aeroallergens or food allergens...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28241038/spatial-clustering-and-local-risk-of-leprosy-in-s%C3%A3-o-paulo-brazil
#3
Antônio Carlos Vieira Ramos, Mellina Yamamura, Luiz Henrique Arroyo, Marcela Paschoal Popolin, Francisco Chiaravalloti Neto, Pedro Fredemir Palha, Severina Alice da Costa Uchoa, Flávia Meneguetti Pieri, Ione Carvalho Pinto, Regina Célia Fiorati, Ana Angélica Rêgo de Queiroz, Aylana de Souza Belchior, Danielle Talita Dos Santos, Maria Concebida da Cunha Garcia, Juliane de Almeida Crispim, Luana Seles Alves, Thaís Zamboni Berra, Ricardo Alexandre Arcêncio
BACKGROUND: Although the detection rate is decreasing, the proportion of new cases with WHO grade 2 disability (G2D) is increasing, creating concern among policy makers and the Brazilian government. This study aimed to identify spatial clustering of leprosy and classify high-risk areas in a major leprosy cluster using the SatScan method. METHODS: Data were obtained including all leprosy cases diagnosed between January 2006 and December 2013. In addition to the clinical variable, information was also gathered regarding the G2D of the patient at diagnosis and after treatment...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28166976/biopsy-of-bovine-embryos-produced-in%C3%A2-vivo-and-in%C3%A2-vitro-does-not-affect-pregnancy-rates
#4
Regivaldo Vieira de Sousa, Célia Regina da Silva Cardoso, Guilberth Butzke, Margot Alves Nunes Dode, Rodolfo Rumpf, Maurício Machaim Franco
Assisted reproductive techniques have significantly contributed to animal breeding programs. Similarly, genomics has provided important information and tools to improve the accuracy of selection. However, the greatest benefits of those tools can only be expected when they are combined, allowing animals to be selected accurately early in life. Therefore, obtaining DNA samples from embryos without compromising their viability is essential for the consolidation of preimplantation genomic selection. We aimed to evaluate the effect on the gestation rate of conducting a biopsy of in vivo (VV) and in vitro-produced (IVP) bovine embryos...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28137231/insp3-signaling-in-apicomplexan-parasites
#5
Celia R S Garcia, Eduardo Alves, Pedro H S Pereira, Paula J Bartlett, Andrew P Thomas, Katsuhiko Mikoshiba, Helmut Plattner, L David Sibley
Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell functions. Specifically, the ability to generate myo-inositol 1,4,5-trisphosphate (InsP3) via phospholipase C (PLC) dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to InsP3 and diacylglycerol (DAG) initiates intracellular calcium signaling events representing a fundamental signaling mechanism dependent on PIs. InsP3 produced by PI turnover as a second messenger causes intracellular calcium release, especially from endoplasmic reticulum, by binding to the InsP3 receptor (InsP3R)...
January 30, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28076540/self-reported-occupational-accidents-among-brazil-s-adult-population-based-on-data-from-the-2013-national-health-survey
#6
Deborah Carvalho Malta, Sheila Rizzato Stopa, Marta Maria Alves da Silva, Célia Landmann Szwarcwald, Marco da Silveira Franco, Flavia Vinhaes Santos, Elaine Leandro Machado, Carlos Minayo Gómez
Objective: to provide an overview of occupational accidents among Brazil's adult population. Methods: descriptive study using data from the 2013 National Health Survey. Results: A total of 4.9 million workers mentioned having suffered some kind of work-related accident, which is equivalent to 3.4% (CI95% 4.6-5.6) of Brazil's adult population. Prevalence rates were higher among men, young adults aged between 18 and 39 years, and black people and in the North Region of the country...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28024233/a-critical-review-of-social-and-health-inequalities-in-the-nursing-curriculum
#7
REVIEW
Célia Alves Rozendo, Anna Santos Salas, Brenda Cameron
CONTEXT: Social and health inequalities are a reality around the world and one of the most important challenges in the current age. Nurse educators can respond to these challenges by incorporating curricular components to identify and intervene in social and health inequalities. OBJECTIVE: To examine how social and health inequalities have been addressed in the nursing curriculum. DESIGN: Informed by the work of Paulo Freire, a critical literature review was performed to examine how social and health inequalities have been addressed in the nursing curriculum...
March 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27889888/characteristics-of-ash-and-particle-emissions-during-bubbling-fluidised-bed-combustion-of-three-types-of-residual-forest-biomass
#8
João Peres Ribeiro, Estela Domingos Vicente, Célia Alves, Xavier Querol, Fulvio Amato, Luís A C Tarelho
Combustion of residual forest biomass (RFB) derived from eucalypt (Eucalyptus globulus), pine (Pinus pinaster) and golden wattle (Acacia longifolia) was evaluated in a pilot-scale bubbling fluidised bed reactor (BFBR). During the combustion experiments, monitoring of temperature, pressure and exhaust gas composition has been made. Ash samples were collected at several locations along the furnace and flue gas treatment devices (cyclone and bag filter) after each combustion experiment and were analysed for their unburnt carbon content and chemical composition...
November 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27798950/comparative-proteome-analysis-of-xanthomonas-citri-subsp-citri-periplasmic-proteins-reveals-changes-in-cellular-envelope-metabolism-during-in-vitro-pathogenicity-induction
#9
Juliana Artier, Flávia da Silva Zandonadi, Flávia Maria de Souza Carvalho, Bianca Alves Pauletti, Adriana Franco Paes Leme, Carolina Moretto Carnielli, Heloisa Sobreiro Selistre de Araujo, Maria Célia Bertolini, Jesus Aparecido Ferro, José Belasque Júnior, Julio Cezar Franco de Oliveira, Maria Teresa Marques Novo-Mansur
Citrus canker is a plant disease caused by gram-negative bacteria from the genus Xanthomonas, and the most virulent species is Xanthomonas citri subsp.citri (XAC), which attacks a wide range of citrus hosts. Differential proteomic analysis of periplasm-enriched fraction was performed for XAC cells grown in pathogenicity-inducing (XAM-M) and pathogenicity non-inducing (NB) media, using two-dimensional electrophoresis combined with liquid chromatography-tandem mass spectrometry. Among the 40 proteins identified, transglycosylase was detected in a highly abundant spot in XAC cells grown under inducing condition...
October 31, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27776788/diversity-of-polymyxin-resistance-mechanisms-among-acinetobacter-baumannii-clinical-isolates
#10
Raquel Girardello, Marina Visconde, Rodrigo Cayô, Regina Célia Bressan Queiroz de Figueiredo, Marcelo Alves da Silva Mori, Nilton Lincopan, Ana Cristina Gales
Polymyxins have become drugs of last resort for treatment of multi-drug resistant (MDR) Gram-negative infections. However, the mechanisms of resistance to this compound have not been completely elucidated. In this study, we evaluated the mechanisms of resistance to this antimicrobial in two A. baumannii clinical isolates, respectively, susceptible (A027) and resistant (A009) to polymyxin B before and after polymyxin B exposure (A027(ind) and A009(ind)). The pmrAB and lpxACD were sequenced and their transcriptional levels were analyzed by qRT-PCR...
January 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27769244/natural-killer-cell-based-adoptive-immunotherapy-eradicates-and-drives-differentiation-of-chemoresistant-bladder-cancer-stem-like-cells
#11
Margarida Ferreira-Teixeira, Daniela Paiva-Oliveira, Belmiro Parada, Vera Alves, Vitor Sousa, Obinna Chijioke, Christian Münz, Flávio Reis, Paulo Rodrigues-Santos, Célia Gomes
BACKGROUND: High-grade non-muscle invasive bladder cancer (NMIBC) has a high risk of recurrence and progression to muscle-invasive forms, which seems to be largely related to the presence of tumorigenic stem-like cell populations that are refractory to conventional therapies. Here, we evaluated the therapeutic potential of Natural Killer (NK) cell-based adoptive immunotherapy against chemoresistant bladder cancer stem-like cells (CSCs) in a pre-clinical relevant model, using NK cells from healthy donors and NMIBC patients...
October 21, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27698473/apocynin-and-nox2-regulate-nf-%C3%AE%C2%BAb-by-modifying-thioredoxin-1-redox-state
#12
Silvia Cellone Trevelin, Célio Xavier Dos Santos, Raphael Gomes Ferreira, Larissa de Sá Lima, Rangel Leal Silva, Cristoforo Scavone, Rui Curi, José Carlos Alves-Filho, Thiago Mattar Cunha, Pérsio Roxo-Júnior, Maria-Célia Cervi, Francisco Rafael Martins Laurindo, John Stephen Hothersall, Andrew M Cobb, Min Zhang, Aleksandar Ivetic, Ajay M Shah, Lucia Rossetti Lopes, Fernando Queiroz Cunha
The reactive-oxygen-species-(ROS)-generating-enzyme Nox2 is essential for leukocyte anti-microbial activity. However its role in cellular redox homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear. Herein, we show Nox2 activation favors thioredoxin-1 (TRX-1)/p40phox interaction, which leads to exclusion of TRX-1 from the nucleus. In contrast, the genetic deficiency of Nox2 or its pharmacological inhibition with apocynin (APO) results in reductive stress after lipopolysaccharide-(LPS)-cell stimulation, which causes nuclear accumulation of TRX-1 and enhanced transcription of inflammatory mediators through nuclear-factor-(NF)-κB...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27637169/tlr-and-nlrp3-inflammasome-expression-deregulation-in-macrophages-of-adult-rats-subjected-to-neonatal-malnutrition-and-infected-with-methicillin-resistant-staphylococcus-aureus
#13
Natália Gomes de Morais, Thacianna Barreto da Costa, Joana Maria Bezerra de Lira, Suênia da Cunha Gonçalves de Albuquerque, Valéria Rêgo Alves Pereira, Milena de Paiva Cavalcanti, Célia Maria Machado Barbosa de Castro
OBJECTIVES: Nutritional aggression in critical periods may lead to epigenetic changes that affect gene expression. The aim of this study was to assess the effect of neonatal malnutrition on the expression of toll-like receptor (TLR)-2, TLR-4, and NLRP3 receptors, caspase-1 enzyme, and interleukin (IL)-1 β production in macrophages infected with methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) Staphylococcus aureus. METHODS: Wistar rats (N = 24) were divided in two distinct groups: nourished (17% casein) and malnourished (8% casein)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27554401/problematizing-in-nursing-education-freire-s-contribution-to-transformative-practice
#14
EDITORIAL
Célia Alves Rozendo, Anna Santos Salas, Brenda Cameron
No abstract text is available yet for this article.
August 10, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27509548/-a-street-clinic-in-a-state-capital-in-northeast-brazil-from-the-perspective-of-homeless-people
#15
Cíntia Priscila da Silva Ferreira, Célia Alves Rozendo, Givânya Bezerra de Melo
The objective of this study was to evaluate the Street Clinic strategy in Maceió, Alagoas State, Brazil, from the perspective of its users. This was a qualitative study in coverage areas of the Street Clinic in Maceió. Research subjects were 18 homeless individuals assisted by the clinic (10 men and 8 women), ranging from 20 to 40 years of age. Data were collected from September 2014 to February 2015 using a semi-structured interview. Content analysis was applied to the data and identified two categories: the first, the Street Clinic as such, revealed the strategy's critical points, challenges, and potentialities; the second showed the Street Clinic as social support, affect, and hope for change for the homeless...
August 8, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27496542/osmotic-stress-adaptation-of-paracoccidioides-lutzii-pb01-monitored-by-proteomics
#16
Leandro Nascimento da Silva Rodrigues, Wesley de Almeida Brito, Ana Flávia Alves Parente, Simone Schneider Weber, Alexandre Melo Bailão, Luciana Casaletti, Clayton Luiz Borges, Célia Maria de Almeida Soares
The ability to respond to stressful conditions is essential for most living organisms. In pathogenic organisms, this response is required for effective transition from a saprophytic lifestyle to the establishment of pathogenic interactions within a susceptible host. Hyperosmotic stress has been used as a model to study signal transduction and seems to cause many cellular adaptations, including the alteration of protein expression and cellular volume as well as size regulation. In this work, we evaluated the proteomic profile of Paracoccidioides lutzii Pb01 yeast cells during osmotic stress induced by potassium chloride...
October 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27430578/-it-is-not-just-about-the-alcohol-service-users-views-about-individualised-and-standardised-clinical-assessment-in-a-therapeutic-community-for-alcohol-dependence
#17
Paula Cristina Gomes Alves, Célia Maria Dias Sales, Mark Ashworth
BACKGROUND: The involvement of service users in health care provision in general, and specifically in substance use disorder treatment, is of growing importance. This paper explores the views of patients in a therapeutic community for alcohol dependence about clinical assessment, including general aspects about the evaluation process, and the specific characteristics of four measures: two individualised and two standardised. METHODS: A focus group was conducted and data were analysed using a framework synthesis approach...
2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/27411067/bioactivities-of-the-ethanol-extract-from-ageratum-fastigiatum-branches-antioxidant-antinociceptive-and-anti-inflammatory
#18
Glauciemar Del-Vechio-Vieira, Bruna C S Santos, Maria Silvana Alves, Aílson L A Araújo, Célia H Yamamoto, Míriam A O Pinto, Maria Auxiliadora C Kaplan, Orlando V Sousa
The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation...
July 11, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27343792/marfan-syndrome-new-diagnostic-criteria-same-anesthesia-care-case-report-and-review
#19
Maria Rita Araújo, Céline Marques, Sara Freitas, Rita Santa-Bárbara, Joana Alves, Célia Xavier
BACKGROUND: Marfan's Syndrome (MFS) is a disorder of connective tissue, mainly involving the cardiovascular, musculoskeletal, and ocular systems. The most severe problems include aortic root dilatation and dissection. Anesthetic management is vital for the improvement on perioperative morbidity. CASE REPORT: 61-year-old male with MFS, presenting mainly with pectus carinatum, scoliosis, ectopia lens, previous spontaneous pneumothorax and aortal aneurysm and dissection submitted to thoracoabdominal aortic prosthesis placement...
July 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27338819/law-13-269-2016-clamor-by-society-trumps-the-scientific-method
#20
Sandra Mara Campos Alves, Maria Célia Delduque, Alethele Oliveira Santos
No abstract text is available yet for this article.
June 20, 2016: Cadernos de Saúde Pública
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