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high versus low dose caffeine for apnea of prematurity

Sameh Mohammed, Islam Nour, Abd Elazeez Shabaan, Basma Shouman, Hesham Abdel-Hady, Nehad Nasef
UNLABELLED: The optimum caffeine dose in preterm infants has not been well investigated. We aimed to compare the efficacy and safety of high versus low-dose caffeine citrate on apnea of prematurity (AOP) and successful extubation of preterm infants from mechanical ventilation. We compared high-dose (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) versus low-dose (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) caffeine citrate in preterm infants <32 weeks gestation, presented with AOP within the first 10 days of life...
July 2015: European Journal of Pediatrics
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