Shingo Kishi, Shiori Mori, Rina Fujiwara-Tani, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Kei Goto, Takamitsu Sasaki, Makito Miyake, Satoru Sasagawa, Masashi Kawaichi, Yi Luo, Ujjal Kumar Bhawal, Kiyohide Fujimoto, Hidemitsu Nakagawa, Hiroki Kuniyasu
N-methyl-glycine (sarcosine) is known to promote metastatic potential in some cancers; however, its effects on bladder cancer are unclear. T24 cells derived from invasive cancer highly expressed GNMT, and S-adenosyl methionine (SAM) treatment increased sarcosine production, promoting proliferation, invasion, anti-apoptotic survival, sphere formation, and drug resistance. In contrast, RT4 cells derived from non-invasive cancers expressed low GNMT, and SAM treatment did not produce sarcosine and did not promote malignant phenotypes...
November 15, 2023: International Journal of Molecular Sciences