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https://www.readbyqxmd.com/read/28214212/primary-multiple-tumor-with-affection-of-the-thyroid-gland-uterus-urinary-bladder-mammary-gland-and-other-organs
#1
А Romaniuk, M Lyndin, V Smiyanov, Vl Sikora, A Rieznik, Y Kuzenko, H Budko, Yu Moskalenko, L Karpenko, Vol Sikora, O Gladchenko
BACKGROUND: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. CASE PRESENTATION: We showed a case of multiple primary tumor with metahronic lesion of the thyroid, uterus and breast, followed by synchronous benign tumors of the subcutaneous fat, urinary bladder and gallbladder were considered...
January 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28193625/deep-sequencing-of-urinary-rnas-for-bladder-cancer-molecular-diagnostics
#2
Mandy L Y Sin, Kathleen E Mach, Rahul Sinha, Fan Wu, Dharati Trivedi, Emanuela Altobelli, Kristin C Jensen, Debashis Sahoo, Ying Lu, Joseph C Liao
PURPOSE: The majority of bladder cancer patients present with localized disease and are managed by transurethral resection. However, the high rate of recurrence necessitates lifetime cystoscopic surveillance. Developing a sensitive and specific urine-based test would significantly improve bladder cancer screening, detection, and surveillance. EXPERIMENTAL DESIGN: RNA-seq was used for biomarker discovery to directly assess the gene expression profile of exfoliated urothelial cells in urine derived from bladder cancer patients (n=13) and controls (n=10)...
February 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28165132/nonmuscle-invasive-bladder-cancer-what-s-changing-and-what-has-changed
#3
Ramanitharan Manikandan, Oscar Rodriguez, Rubén Parada, Joan Palou Redorta
PURPOSE: Nonmuscle-invasive bladder cancer (NMIBC) is a challenging disease to manage primarily due to its varied clinical course. The management of NMIBC has witnessed a widespread change with respect to its diagnosis and treatment. Although transurethral resection (TUR) and adjuvant bacillus Calmette-Guerin (BCG) stills remain the cornerstone, newer protocols has come into vogue to achieve optimal care. On the basis of a literature review, we aimed to establish 'what changes has already occurred and what is expected in the future' in NMIBC...
February 3, 2017: Urologia
https://www.readbyqxmd.com/read/28128913/overexpression-of-uhrf1-gene-correlates-with-the-major-clinicopathological-parameters-in-urinary-bladder-cancer
#4
Skender Saidi, Zivko Popov, Vesna Janevska, Sasho Panov
INTRODUCTION: Recently, expression of the UHRF1 gene was found to be up-regulated in numerous neoplasms, including the urinary bladder transitional cell carcinoma (TCC). OBJECTIVE: The aim of our study was to determine if the expression levels of UHRF1 gene correlates with the major pathological characteristics of the tumor and patients' clinical outcome. MATERIALS AND METHODS: In our study, we have analyzed the tissue samples derived from group of 70 patients with histologically confirmed TCC of the urinary bladder, while normal urinary bladder mucosa obtained from 40 patients with nonmalignant diseases was used as a negative control group...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28117816/a-murine-orthotopic-bladder-tumor-model-and-tumor-detection-system
#5
Sin Mun Tham, Kesavan Esuvaranathan, Ratha Mahendran
This protocol describes the generation of bladder tumors in female C57BL/6J mice using the murine bladder cancer cell line MB49, which has been modified to secrete human Prostate Specific Antigen (PSA), and the procedure for the confirmation of tumor implantation. In brief, mice are anesthetized using injectable drugs and are made to lay in the dorsal position. Urine is vacated from the bladder and 50 µL of poly-L-lysine (PLL) is slowly instilled at a rate of 10 µL/20 s using a 24 G IV catheter. It is left in the bladder for 20 min by stoppering the catheter...
January 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28116879/physical-activity-in-the-prevention-and-management-of-bladder-cancer
#6
Roy J Shephard
INTRODUCTION: The aim was to examine the role of physical activity in reducing the risk of bladder cancer, and in managing established disease. EVIDENCE ACQUISITION: A systematic search of Ovid/Medline from 1996 to June 2016 coupled the term urinary bladder neoplasms (25,061 hits) with markers of physical activity (exercise, physical activity, physical education/training, athletes, and physical fitness, a total of 246,683 unique entries). Of 42 titles identified, 18 relevant abstracts were supplemented by reviewing reference lists and personal files to yield 21 articles on prevention of bladder cancer, and 8 on physical activity in disease management...
January 23, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28049011/fgfr3-tert-and-otx1-as-urinary-biomarker-combination-for-surveillance-of-bladder-cancer-patients-in-a-large-prospective-multicenter-study
#7
Willemien Beukers, Kirstin A van der Keur, Raju Kandimalla, Yvonne Vergouwe, Ewout W Steyerberg, Joost L Boormans, Jorgen B Jensen, José A Lorente, Francisco X Real, Ulrike Segersten, Torben F Orntoft, Nuria Malats, Per-Uno Malmström, Lars Dyrskjot, Ellen C Zwarthoff
PURPOSE: Non-muscle invasive bladder cancer (NMIBC) patients are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 are investigated as a diagnostic urinary marker combination during follow-up of patients with primary NMIBC. MATERIAL AND METHODS: In this international multi-center prospective study 977 NMIBC patients were included. Urines (n= 2496) were collected prior to cystoscopy during regular visits. Sensitivity was estimated for detection of concomitant recurrences...
December 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28038452/inhibition-of-long-non-coding-rna-uca1-by-crispr-cas9-attenuated-malignant-phenotypes-of-bladder-cancer
#8
Shuai Zhen, Ling Hua, Yun-Hui Liu, Xiao-Min Sun, Meng-Meng Jiang, Wei Chen, Le Zhao, Xu Li
CRISPR/Cas9 is a novel and effective genome editing technique, but its application is not widely expanded to manipulate long non-coding RNA (lncRNA) expression. The lncRNA urothelial carcinoma-associated 1 (UCA1) is upregulated in bladder cancer and promotes the progression of bladder cancer. Here, we design gRNAs specific to UCA1 and construct CRISPR/Cas9 systems targeting UCA1. Single CRISPR/Cas9-UCA1 can effectively inhibit UCA1 expression when transfected into 5637 and T24 bladder cancer cells, while the combined transfection of the two most effective CRISPR/Cas9-UCA1s can generate more satisfied inhibitory effect...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025079/%C3%AE-iii-tubulin-overexpression-is-linked-to-agressive-tumor-features-and-genetic-instability-in-urinary-bladder-cancer
#9
Andrea Hinsch, Aref Chaker, Christian Burdelski, Christina Koop, Maria Christina Tsourlakis, Stefan Steurer, Michael Rink, Till Simon Eichenauer, Waldemar Wilczak, Corinna Wittmer, Margit Fisch, Ronald Simon, Guido Sauter, Franziska Büschek, Till Clauditz, Sarah Minner, Frank Jacobsen
Development of genetic instability is a hallmark of tumor progression. Type III ß-tubulin (TUBB3) is a component of microtubules involved in chromosome segregation. Its overexpression has been linked to adverse features of urinary bladder cancer. To investigate the role of TUBB3 for development of genetic instability, we compared TUBB3 expression with histopathological features and surrogate markers of genetic instability and tumor aggressiveness, copy number changes of HER2, TOP2A, CCND1, RAF1, and FGFR1, nuclear accumulation of p53, and cell proliferation, in a tissue microarray with >700 bladder cancers...
December 23, 2016: Human Pathology
https://www.readbyqxmd.com/read/27936466/dpp4-cd26-overexpression-in-urothelial-carcinoma-confers-an-independent-prognostic-impact-and-correlates-with-intrinsic-biological-aggressiveness
#10
Peir-In Liang, Bi-Wen Yeh, Wei-Ming Li, Ti-Chun Chan, I-Wei Chang, Chun-Nung Huang, Ching-Chia Li, Hung-Lung Ke, Hsin-Chih Yeh, Wen-Jeng Wu, Chien-Feng Li
Urothelial carcinoma (UC) is common cancer worldwide. The molecular aberrations regarding tumor progression remain unclear. Pericellular proteolysis is crucial in tumorigenesis, but its significance is unexplored in UC. By data mining the datasets in Gene Expression Omnibus, specifically focus on the proteolysis pathway, and followed by a preliminary validation in a pilot batch of tumor samples, we identified that the upregulation of dipeptidyl peptidase 4 (DPP4) was most significantly associated with clinical aggressiveness of UCs...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27896485/biomarkers-for-precision-medicine-in-bladder-cancer
#11
REVIEW
Takahiro Kojima, Koji Kawai, Jun Miyazaki, Hiroyuki Nishiyama
Bladder cancer (BC) is classified as non-muscle-invasive BC (NMIBC) or muscle-invasive BC (MIBC). Because the recurrence and mortality rates of BC are high, suitable biomarkers for early detection, evaluation of prognosis, and surveillance of drug responses are needed. Urinary markers simplify surveillance schedules and improve early detection of tumors, especially in NMIBC. Various markers have been identified at DNA, RNA, and protein levels with different sensitivities and specificities. Several biomarkers show a higher sensitivity than urinary cytology, but they are not accurate enough to replace it...
November 29, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27894096/shed-urinary-alcam-is-an-independent-prognostic-biomarker-of-three-year-overall-survival-after-cystectomy-in-patients-with-bladder-cancer
#12
Shanna A Arnold Egloff, Liping Du, Holli A Loomans, Alina Starchenko, Pei-Fang Su, Tatiana Ketova, Paul B Knoll, Jifeng Wang, Ahmed Q Haddad, Oluwole Fadare, Justin M Cates, Yair Lotan, Yu Shyr, Peter E Clark, Andries Zijlstra
Proteins involved in tumor cell migration can potentially serve as markers of invasive disease. Activated Leukocyte Cell Adhesion Molecule (ALCAM) promotes adhesion, while shedding of its extracellular domain is associated with migration. We hypothesized that shed ALCAM in biofluids could be predictive of progressive disease. ALCAM expression in tumor (n = 198) and shedding in biofluids (n = 120) were measured in two separate VUMC bladder cancer cystectomy cohorts by immunofluorescence and enzyme-linked immunosorbent assay, respectively...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27859848/evaluation-of-double-immunocytochemical-staining-for-ck20-and-p53-as-a-potential-adjunct-to-cytology-for-urothelial-cancer-diagnosis
#13
M Lenos, I Katafigiotis, K Vrettou, D Papaioannou, F Malta, E-A Trigka, S Sousouris, C Constantinides, P Mikou
OBJECTIVE: To evaluate double immunocytochemical staining with p53 and CK20, as a tool for improving the accuracy of urinary cytology. The aim of the present study was to clarify the diagnostic significance of the expression of these markers and to investigate the possibility of using this information for better monitoring of bladder cancer patients during follow-up. MATERIAL AND METHODS: One hundred and twenty-five urine cytology cases were retrieved with corresponding histology from our files...
November 18, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27785422/genetics-and-biological-markers-in-urachal-cancer
#14
REVIEW
Mark A Behrendt, Bas W G van Rhijn
Urachal cancer (UraC) is a rare tumor entity that usually develops at the basis of the remnant embryologic urachus. Consisting of mostly adenocarcinomas, most patients present with secondary symptoms due to an advanced stage with urinary bladder infiltration. One third of patients are already metastasized at presentation rendering them unsuitable for curative surgical treatment. In order to improve staging, treatment and follow-up, adequate knowledge about the genetic origin and potential markers is necessary...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27769440/gelatin-modified-gold-nanoparticles-for-direct-detection-of-urinary-total-gelatinase-activity-diagnostic-value-in-bladder-cancer
#15
Ahmed I Nossier, Ola S Mohammed, Rasha R Fakhr El-Deen, Ashraf S Zaghloul, Sanaa Eissa
Matrix metalloproteinases (MMPs), in particularly gelatinases (MMP-2 and MMP-9) were reported as urinary markers of bladder cancer. In this work, we developed a simple colorimetric gold nanoparticle (AuNP) assay for rapid and sensitive detection of urinary total gelatinase activity based on the surface plasmon resonance (SPR) property of AuNPs. Gelatin-modified AuNPs were stably suspended in solution even upon addition of an aggregation inducer as 6-mercaptohexan-1-ol (6-MCH). Gelatinases digest gelatin capping...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27765044/bladder-chondrosarcoma-plus-urothelial-carcinoma-in-recurred-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-report-and-literature-review
#16
Min Hyun Cho, Sung Han Kim, Weon Seo Park, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
BACKGROUND: Sarcomatoid urothelial carcinoma (SUC) is a rare malignant neoplasm of the urinary bladder comprising 0.2-0.6 % of all histological bladder tumor subtypes. It presents as a high-stage malignancy and exhibits aggressive biological behavior, regardless of the treatment employed. It is defined as histologically indistinguishable from sarcoma and as a high-grade biphasic neoplasm with malignant epithelial and mesenchymal components. The mean age of patients presenting with SUC is 66 years, and the male-to-female ratio is 3:1...
October 20, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27751843/extracellular-vesicles-as-a-source-for-non-invasive-biomarkers-in-bladder-cancer-progression
#17
Zoraida Andreu, Renan Otta Oshiro, Alberto Redruello, Soraya López-Martín, Cristina Gutiérrez-Vázquez, Esperanza Morato, Ana Isabel Marina, Carlos Olivier Gómez, María Yáñez-Mó
Bladder cancer is the second most frequent malignancy of the urinary tract after prostate cancer. Current diagnostic techniques, such as cystoscopy and biopsies are highly invasive and accompanied of undesirable side effects. Moreover, there are no suitable biomarkers for relapse or progression prognosis. We analysed whether the specific composition of microRNAs (miRNAs) and proteins of extracellular vesicles (EVs) that urothelial tumour cells of bladder mucosa release into the urine, could reflect their pathologic condition...
October 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27660385/multiplatform-biomarker-discovery-for-bladder-cancer-recurrence-diagnosis
#18
Marine De Paoli, Selma Gogalic, Ursula Sauer, Claudia Preininger, Hardev Pandha, Guy Simpson, Andras Horvath, Christophe Marquette
Purpose. Nonmuscle invasive bladder cancer (BCa) has a high recurrence rate requiring lifelong surveillance. Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of recurrent bladder cancer. However, no single marker can achieve the required accuracy. The purpose of this study was to select a multiparameter panel, comprising urinary biomarkers and clinical parameters, for BCa recurrence diagnosis. Experimental Design. Candidate biomarkers were measured in urine samples of BCa patients with recurrence and BCa patients without recurrence...
2016: Disease Markers
https://www.readbyqxmd.com/read/27611947/detection-of-multiple-mutations-in-urinary-exfoliated-cells-from-male-bladder-cancer-patients-at-diagnosis-and-during-follow-up
#19
Rossana Critelli, Francesca Fasanelli, Marco Oderda, Silvia Polidoro, Manuela Bianca Assumma, Clara Viberti, Mirko Preto, Paolo Gontero, Giuseppina Cucchiarale, Irene Lurkin, Ellen C Zwarthoff, Paolo Vineis, Carlotta Sacerdote, Giuseppe Matullo, Alessio Naccarati
Most bladder cancer (BC) patients need life-long, invasive and expensive monitoring and treatment, making it a serious burden on the health system. Thus, there is a pressing need for an accurate test to assist diagnosis and surveillance of BC as an alternative to cystoscopy. Mutations in human TERT, FGFR3, PIK3CA, and RAS genes have been proposed as potential molecular markers in bladder tumor. Their concomitant presence in urine samples has not been fully explored.We investigated a panel of mutations in DNA from exfoliated urinary cells of 255 BC patients at diagnosis...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27601277/epithelial-to-mesenchymal-transition-and-its-correlation-with-clinicopathologic-features-in-patients-with-urothelial-carcinoma-of-the-bladder
#20
Rinni Singh, Jamal A Ansari, Niharika Maurya, Anil Mandhani, Vinita Agrawal, Minal Garg
INTRODUCTION: Epithelial-to-mesenchymal transition (EMT) is a dynamic process in the pathogenesis of urinary bladder cancer. Despite significant advancements in its diagnosis and treatment, the outcomes have more or less remained the same. In the present study, the expression of EMT markers was investigated to evaluate its prognostic significance in patients with non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS: The present study was undertaken to examine the expression of EMT markers, including E-cadherin, N-cadherin, vimentin, Snail, Twist, Zeb, and Slug, on 28 bladder tumor tissues (15 cases of NMIBC and 13 of MIBC) using reverse transcription-polymerase chain reaction...
August 9, 2016: Clinical Genitourinary Cancer
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