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urinary markers bladder cancer

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https://www.readbyqxmd.com/read/29143974/%C3%AE-h2ax-formation-in-the-urinary-bladder-of-rats-treated-with-two-norharman-derivatives-obtained-from-o-toluidine-and-aniline
#1
T Toyoda, Y Totsuka, K Matsushita, T Morikawa, N Miyoshi, K Wakabayashi, K Ogawa
Aminomethylphenylnorharman (AMPNH) and aminophenylnorharman (APNH) are mutagenic norharman derivatives obtained from o-toluidine and aniline, respectively. APNH is carcinogenic to the urinary bladder of rats and present in urine samples of healthy volunteers, indicating that norharman derivatives may be associated with cancer development in the urinary bladder of humans. To evaluate the possible role of AMPNH and APNH in bladder carcinogenesis, we examined the formation of γ-H2AX, a DNA damage response marker, in the urinary bladder of rats...
November 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29130146/recent-developments-in-the-search-for-urinary-biomarkers-in-bladder-cancer
#2
REVIEW
Aaron Leiblich
PURPOSE OF REVIEW: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence. RECENT FINDINGS: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information. Furthermore, the isolation and characterisation of extracellular vesicles (EVs) from the urine patients with bladder cancer provide an exciting new development in biomarker research that is set to expand in the coming years...
November 13, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29115542/imp3-overexpression-occurs-in-various-important-cancer-types-and-is-linked-to-aggressive-tumor-features-a-tissue-microarray-study-on-8-877-human-cancers-and-normal-tissues
#3
Christoph Burdelski, Nilofar Jakani-Karimi, Frank Jacobsen, Christina Möller-Koop, Sarah Minner, Ronald Simon, Guido Sauter, Stefan Steurer, Till S Clauditz, Waldemar Wilczak
IMP3 is an RNA binding protein required for ribosomal RNA processing, which has been suggested to be a prognostic marker in a large variety of human types of cancer. However, available data on the prevalence of IMP3 expression are largely discrepant. To systematically investigate the epidemiology and clinical relevance of IMP3 expression in human cancers we employed a two-step tissue microarrays (TMAs) approach. First, a normal tissue TMA and a multi-tumor TMA were analyzed for immunohistochemically detectable expression of IMP3 in 76 different normal tissue types and 3889 cancer samples from 95 different tumor categories...
November 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29115014/impact-of-variant-microscopic-interpretation-of-the-ucyt-immunocytological-urine-test-for-the-detection-of-bladder-cancer
#4
Susanne Deininger, Tilman Todenhöfer, Jörg Hennenlotter, Valentina Gerber, Jennifer Schwarz, Jens Bedke, Christian Schwentner, Arnulf Stenzl, Steffen Rausch
BACKGROUND: Urinary marker tests for bladder cancer (BC) detection and surveillance represent a desirable approach to diagnosis and follow-up. The SCIMEDX uCyt+ assay detects antigens expressed by BC cells (mucin glycoprotein and carcinoembryonic antigen) using green and red fluorescence and is interpreted according to specific manufacturer's recommendations. In the present study, we evaluated divergent approaches of numeric and morphological analysis of uCyt+ to generate a rationale for alternative test interpretation strategies...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29055653/predicting-response-to-intravesical-bacillus-calmette-gu%C3%A3-rin-immunotherapy-are-we-there-yet-a-systematic-review
#5
REVIEW
Ashish M Kamat, Roger Li, Michael A O'Donnell, Peter C Black, Morgan Roupret, James W Catto, Eva Comperat, Molly A Ingersoll, Wim P Witjes, David J McConkey, J Alfred Witjes
CONTEXT: Bacillus Calmette-Guérin (BCG) is currently the most effective intravesical therapy for nonmuscle invasive bladder cancer, reducing not only recurrence rates but also preventing progression and reducing deaths. However, response rates to BCG vary widely and are dependent on a multitude of factors. OBJECTIVE: To review existing data on clinical, pathologic, immune, and molecular markers that allow prediction of BCG response. EVIDENCE ACQUISITION: PubMed and MEDLINE search of English language literature was conducted from its inception to July 2017 using appropriate search terms...
October 18, 2017: European Urology
https://www.readbyqxmd.com/read/29024250/non-invasive-detection-of-bladder-cancer-via-expression-targeted-gene-delivery
#6
Yunlan Fang, B Wolfson, W T Godbey
BACKGROUND: Because of the time and expense associated with the procedures and possible distress to the patient, cystoscopy or other imaging techniques are typically not used for bladder cancer detection before symptoms become present. Alternatively, commercial assays for urinary tumor markers exist but are marred by low sensitivity and high cost. There is a need for a simple and sensitive means of tumor detection, such as via the analysis of urine. METHODS: Plasmids encoding the secretable reporter Gaussia luciferase (G...
October 11, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28977980/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-urothelial-carcinoma-of-the-upper-urinary-tract-and-bladder-a-systematic-review-and-meta-analysis
#7
Xintao Li, Xin Ma, Lu Tang, Baojun Wang, Luyao Chen, Fan Zhang, Xu Zhang
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967804/ck20-and-p53-immunohistochemical-staining-patterns-in-urinary-bladder-specimens-with-equivocal-atypia-correlation-with-outcomes
#8
Javier A Arias-Stella, Alpa B Shah, Nilesh S Gupta, Sean R Williamson
CONTEXT: - Urinary bladder flat carcinoma in situ (CIS) is a worrisome lesion, requiring aggressive surveillance and treatment. Cytokeratin 20 (CK20) and p53 are common immunohistochemical antibodies used to supplement CIS diagnosis in biopsy samples. However, existing data come primarily from unequivocally benign and malignant specimens. OBJECTIVE: - To correlate these markers in specimens with borderline histology with outcomes. DESIGN: - CK20 and p53 immunohistochemistry was analyzed for staining pattern, classified as CIS pattern (both stains yielding strong labeling of the area of concern), discordant (only 1 stain yielding CIS pattern), indeterminate (1 or both stains yielding partial or equivocal labeling), or benign (both stains yielding a benign pattern)...
October 2, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28953854/expression-of-n-myc-downstream-regulated-gene-2-in-bladder-cancer-and-its-potential-utility-as-a-urinary-diagnostic-biomarker
#9
Miao Zhang, Bo Ren, Zhi Li, Wenyan Niu, Yueling Wang
BACKGROUND Initial diagnosis of carcinoma of the urinary bladder remains challenging. N-Myc downstream-regulated gene 2 (NDRG2) has been reported to be closely correlated with cell differentiation and proliferation in various cancers. However, its clinical significance in diagnosis of bladder cancer remains unclear. The purpose of this study was to detect the expression of NDRG2 and investigate its diagnostic value in bladder cancer. MATERIAL AND METHODS We recruited 127 patients with bladder cancer and 97 healthy controls...
September 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28945275/collagen-content-in-the-bladder-of-men-with-luts-undergoing-open-prostatectomy-a-pilot-study
#10
Marcio A Averbeck, Nelson G De Lima, Gabriela A Motta, Lauro F Beltrao, Nury J Abboud Filho, Clarice P Rigotti, William N Dos Santos, Steven K J Dos Santos, Luis F B Da Silva, Ernani L Rhoden
AIMS: To evaluate the collagen content in the bladder wall of men undergoing open prostate surgery. METHODS: From July 2014 to August 2016, men aged ≥ 50 years, presenting LUTS and undergoing open prostate surgery due to benign prostatic enlargement (BPE) or prostate cancer were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB-V8), lower urinary tract ultrasound, and urodynamics. Bladder biopsies were obtained during open prostatectomy for determination of collagen content (sirius red-picric acid stain; polarized light analysis)...
September 25, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28943911/microplate-magnetic-chemiluminescence-immunoassay-for-detecting-urinary-survivin-in-bladder-cancer
#11
Yanli Chang, Jianjun Xu, Qingyun Zhang
Survivin is a tumor marker for bladder cancer; however the role of urinary survivin levels has not been fully elucidated due to the limitations of current detection methods. Based on two survivin-specific monoclonal antibodies (McAbs) already confirmed through enzyme linked immunosorbent assays, the present study aimed to establish a microplate magnetic chemiluminescence immunoassay (CLIA) for the detection of urinary survivin levels and evaluate its application for the diagnosis of patients with bladder cancer...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28938555/exosomes-of-invasive-urothelial-carcinoma-cells-are-characterized-by-a-specific-mirna-expression-signature
#12
Sophie Baumgart, Sebastian Hölters, Carsten-Henning Ohlmann, Rainer Bohle, Michael Stöckle, Marie Stampe Ostenfeld, Lars Dyrskjøt, Kerstin Junker, Joana Heinzelmann
Muscle-invasive bladder cancer (MIBC) represents a highly aggressive tumor type compared to non-muscle-invasive tumors. MIBC is characterized by specific molecular alterations, which may also modulate extracellular tumorigenic effects. Tumor-associated exosomes, especially exosomal miRNAs, are important regulators in the interaction between tumor cells and tumor microenvironment by affecting tumor-promoting processes in target cells. It is important to analyze whether their exosomal patterns also reflect the specific molecular characteristics of MIBC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28928837/independent-prognostic-mirnas-for-bladder-urothelial-carcinoma
#13
Yingbo Hu, Cheng Cheng, Zhengdong Hong, Ziming Shi
Bladder cancer is the most common malignant tumor of the urinary system, and it is also an important cause of death by cancer globally. Increasing number of studies have shown that miRNAs can be used as prognostic markers for cancers. This study made use of the data available in the Cancer Genome Atlas in order to statistically analyze reported expression levels of miRNAs in samples from bladder urothelial carcinoma patients. Clinical features from a total of 399 patients and the expression data for 1,581 kinds of miRNA were included in the study...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28921833/guideline-of-guidelines-asymptomatic-microscopic-haematuria
#14
REVIEW
Brian J Linder, Edward J Bass, Hugh Mostafid, Stephen A Boorjian
OBJECTIVE: To review major organizational guidelines on the evaluation and management of asymptomatic microscopic haematuria (AMH). METHODS: This is a review of the haematuria guidelines from 1.) American Urological Association (AUA), 2.) consensus statement from the Canadian Urological Association, Canadian Urologic Oncology Group, and Bladder Cancer Canada, 3.) American College of Physicians (ACP), 4.) Joint Consensus Statement of the Renal Association (RA) and British Association of Urological Surgeons (BAUS), and 5...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28889391/urinary-protein-markers-for-the-detection-and-prognostication-of-urothelial-carcinoma
#15
Tibor Szarvas, Péter Nyirády, Takashi Kobayashi, Osamu Ogawa, Charles J Rosser, Hideki Furuya
Bladder cancer diagnosis and surveillance is mainly based on cystoscopy and urine cytology. However, both methods have significant limitations; urine cytology has a low sensitivity for low-grade tumors, while cystoscopy is uncomfortable for the patients. Therefore, in the last decade urine analysis was the subject of intensive research resulting in the identification of many potential biomarkers for the detection, surveillance, or prognostic stratification of bladder cancer. Current trends move toward the development of multiparametric models to improve the diagnostic accuracy compared with single molecular markers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28878597/the-advantages-of-transurethral-resection-of-the-prostate-in-patients-with-an-elevated-or-rising-prostate-specific-antigen-mild-or-moderate-lower-urinary-tract-symptoms-bladder-outlet-obstruction-and-negative-prostate-cancer-imaging-or-prostate-biopsies-a-prospective
#16
Evert Baten, Koenraad van Renterghem
OBJECTIVE: To investigate elevated or rising prostate specific antigen (PSA) as a marker for bladder outlet obstruction (BOO) in patients with minor lower urinary tract symptoms (LUTS) and without prostate cancer. MATERIALS AND METHODS: One hundred and five consecutive patients were prospectively analyzed between 2005 and 2013. All patients were referred to the principal investigator by their general practitioner as a result of an elevated and/or rising PSA. Only patients with minor LUTS [International Prostate Symptom Score (I-PSS) 0-19] and without suspicion for prostate cancer were included...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28871659/overexpression-of-her-2-via-immunohistochemistry-in-canine-urinary-bladder-transitional-cell-carcinoma-a-marker-of-malignancy-and-possible-therapeutic-target
#17
F Millanta, J Impellizeri, L McSherry, G Rocchigiani, L Aurisicchio, G Lubas
Transitional cell carcinoma (TCC) is the most commonly diagnosed neoplasm in the urinary bladder. Distant metastases to the regional lymph nodes, lungs, abdominal organs or bones are noted in up to 50% of dogs at time of death. Surgical excision is often not practical as TCC typically involve the trigone of the bladder and/or occurs multifocally throughout the bladder with field cancerization. Therapeutic approaches are very challenging and the requirement to evaluate alternative therapeutic protocols that may prolong survival times in dogs bearing these tumours is compelling...
September 4, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28859894/the-prevalence-and-impact-of-urinary-marker-testing-in-patients-with-bladder-cancer
#18
Vikram M Narayan, Oluwakayode Adejoro, Ian Schwartz, Matthew Ziegelmann, Sean Elliott, Badrinath R Konety
PURPOSE: Novel urinary tumor markers for bladder cancer may permit early detection and improved oncologic outcomes but data on use is limited. We sought to identify trends in the application of urinary markers and long-term outcomes of urinary tumor marker use in patients with bladder cancer. MATERIALS AND METHODS: Data from the SEER (Surveillance, Epidemiology and End Results)-Medicare database on 2001 to 2011 were used to identify a cohort of 64,450 patients with bladder cancer who underwent urinary marker testing with UroVysion® fluorescence in situ hybridization, or the NMP22® or BTA Stat® test...
August 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28839463/tgf%C3%AE-1-promotes-gemcitabine-resistance-through-regulating-the-lncrna-let-nf90-mir-145-signaling-axis-in-bladder-cancer
#19
Junlong Zhuang, Lan Shen, Lin Yang, Xiaojing Huang, Qun Lu, Yangyan Cui, Xi Zheng, Xiaozhi Zhao, Dianzheng Zhang, Ruimin Huang, Hongqian Guo, Jun Yan
High tumor recurrence is frequently observed in patients with urinary bladder cancers (UBCs), with the need for biomarkers of prognosis and drug response. Chemoresistance and subsequent recurrence of cancers are driven by a subpopulation of tumor initiating cells, namely cancer stem-like cells (CSCs). However, the underlying molecular mechanism in chemotherapy-induced CSCs enrichment remains largely unclear. In this study, we found that during gemcitabine treatment lncRNA-Low Expression in Tumor (lncRNA-LET) was downregulated in chemoresistant UBC, accompanied with the enrichment of CSC population...
2017: Theranostics
https://www.readbyqxmd.com/read/28764970/urinary-exosomal-mir-2909-a-novel-pathognomonic-trait-of-prostate-cancer-severity
#20
S Wani, D Kaul, R S Mavuduru, N Kakkar, A Bhatia
The global occurrence of prostate cancer with a range of patient outcome has prompted various investigators to explore novel molecular biomarkers that can precisely detect and track this type of cancer severity. Several studies suggest that micro-RNAs have emerged to act as a new largely unexplored class of biomarkers because of their inherent stability, resilience and recruitment into exosomes present in various human body fluids. With this study, we aim to reveal the nature of urinary-exosomal miR-2909 & miR-615-3p recruitment in patients suffering from either prostate cancer (n=90) or bladder cancer (n=60) as compared to that in either prostate disease-control subjects having benign prostate hyperplasia (n=10) or healthy subjects (n=50)...
October 10, 2017: Journal of Biotechnology
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