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Prescription Drug Monitoring Database

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https://www.readbyqxmd.com/read/27889834/antiepileptic-drug-use-in-italian-children-over-a-decade
#1
Daria Putignano, Antonio Clavenna, Rita Campi, Angela Bortolotti, Ida Fortino, Luca Merlino, Aglaia Vignoli, Maria Paola Canevini, Maurizio Bonati
PURPOSE: The aim of the study was to evaluate prescription profiles of antiepileptic drugs (AEDs) and to assess hospitalizations and specialist visits in pediatric patients with epilepsy. METHODS: The data sources were administrative health databases of Italy's Lombardy Region, which collect prescriptions for drugs, diagnostic tests, specialist visits, and hospital discharge forms. All patients aged 0-16 years with at least seven AED (group N03A of the International Anatomical Therapeutic Chemical Classification) prescriptions over two consecutive years between 2003 and 2010 were identified and classified as prevalent or incident cases (no prescriptions in two previous years)...
November 26, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#2
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27744401/prevalence-and-factors-associated-with-multiple-provider-episodes-in-texas-an-epidemiological-analysis-of-prescription-drug-monitoring-program-data
#3
Erin A Ferries, Aaron M Gilson, Rajendar R Aparasu, Hua Chen, Michael L Johnson, Marc L Fleming
OBJECTIVE:  Prescription drug abuse has reached epidemic levels, leading to overdose-related morbidity and mortality. Patient and regional-level factors are believed to contribute to higher rates of prescription drug abuse. The objective of this study was to determine the prevalence and factors associated with multiple provider episodes (MPEs) in Texas. METHODS:  This was a retrospective cohort analysis of data from the Texas Prescription Drug Monitoring Program (PDMP) database, linked with Texas county census data...
October 15, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27726885/-cyamemazine-tercian-%C3%A2-exploration-of-extrapyramidal-syndrome-cases-contained-in-the-french-pharmacovigilance-database
#4
Charles Khouri, Marion Lepelley, Céline Villier, Thierry Bougerol, Michel Mallaret
PURPOSE: Cyamemazine (Tercian(®)) is currently the most widely prescribed neuroleptic in France. This widespread use is due to its anxiolytics properties and to a claimed good safety profile. Although, prescription of cyamemazine is not devoid of the risks associated with the use of neuroleptics: extrapyramidal syndromes. This study aims at describing extrapyramidal syndromes induced by cyamemazine registered in the French pharmacovigilance database. METHODS: All spontaneous reports of extrapyramidal syndromes in the French pharmacovigilance database between 1st January 1985 and 31th December 2015 were described and analyzed...
September 15, 2016: Thérapie
https://www.readbyqxmd.com/read/27725022/inappropriate-medicine-prescribing-in-older-south-africans-a-cross-sectional-analysis-of-medicine-claims-data
#5
J A Van Heerden, J R Burger, J J Gerber
BACKGROUND: Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools and criteria are available to promote rational prescribing in older patients. OBJECTIVE: To determine the prevalence of potentially inappropriate prescriptions (PIPs) in older South African patients. METHODS: A retrospective drug utilisation review was conducted using medicine claims data over a 1-year period...
September 9, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27578632/routine-quality-care-assessment-of-schizophrenic-disorders-using-information-systems
#6
Antonio Lora, Emiliano Monzani, Bussy Ibrahim, Davide Soranna, Giovanni Corrao
OBJECTIVE: To assess the quality of mental healthcare provided to patients with schizophrenic disorders in the Italian region of Lombardy. DESIGN: Forty-one clinical indicators were applied to Lombardy's healthcare databases containing data on mental health treatments, hospital admissions, somatic health treatments and pharmaceutical prescriptions. SETTING: All public departments of mental health and private residential facilities in Lombardy...
August 30, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27555801/medicine-reclassification-processes-and-regulations-for-proper-use-of-over-the-counter-self-care-medicines-in-japan
#7
Kaori Nomura, Yuki Kitagawa, Yasukatsu Yuda, Hiromi Takano-Ohmuro
OBJECTIVES: Japan has actively reclassified substances ranging from prescription drugs to over-the-counter (OTC) drugs in recent years. The sale of most OTC drugs was deregulated several times and pharmacists' supervision was deemed no longer mandatory. Japan established a new OTC evaluation system in 2015 to hear opinions from various stakeholders regarding medicine types to be reclassified. This study aimed to examine the new framework to identify candidate substances for reclassification...
2016: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/27518196/initiation-and-persistence-of-pharmacotherapy-for-youths-with-attention-deficit-hyperactivity-disorder-in-taiwan
#8
Liang-Jen Wang, Kang-Chung Yang, Sheng-Yu Lee, Chun-Ju Yang, Ting-Shuo Huang, Tung-Liang Lee, Shin-Sheng Yuan, Yu-Chiau Shyu
BACKGROUND: Pharmacotherapy is an effective therapeutic option for attention deficit hyperactivity disorder (ADHD). Understanding the patterns of medication treatment is crucial for clinical practice. This study employed nationwide population-based data to elucidate the initiation and persistence of pharmacotherapy (immediate-release methylphenidate [IR-MPH], osmotic controlled-release formulations of methylphenidate [OROS-MPH] and atomoxetine [ATX]) for youths with ADHD in Taiwan. METHODS: Patients first receiving an ADHD diagnosis at age 18 or younger between January 2000 and December 2009 (n = 112,140; mean age at ADHD diagnosis: 7...
2016: PloS One
https://www.readbyqxmd.com/read/27411937/changes-in-utilisation-of-antiepileptic-drugs-in-epilepsy-and-non-epilepsy-disorders-a-pharmacoepidemiological-study-and-clinical-implications
#9
Arton Baftiu, Cecilie Johannessen Landmark, Ida Rudberg Rusten, Silje Andrea Feet, Svein I Johannessen, Pål G Larsson
PURPOSE: The purpose of this study was to investigate changes in utilisation of antiepileptic drugs (AEDs) in epilepsy and non-epilepsy disorders in Norway and furthermore to study the retention rates of the most commonly used AEDs in these indications in long-term use. METHODS: The data consisted of all prescriptions of AEDs from Norwegian pharmacies in the Norwegian Prescription Database (NorPD) (2004-2012). Variables included anonymous data regarding age, gender, diagnosis specific reimbursement codes and utilisation of AEDs...
October 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27357262/trends-in-patterns-of-antidepressant-use-in-older-general-population-between-2006-and-2012-following-publication-of-practice-guidelines
#10
Fanny Etchepare, Elodie Pambrun, Hélène Verdoux, Marie Tournier
OBJECTIVE: The French regulatory agency published in 2006 practice guidelines related to the management of depressive and anxiety disorders. The main objective of the study was to assess their impact regarding use and monitoring of antidepressant drug treatment in older patients. The secondary objective was to identify factors associated with compliance with practice guidelines. METHODS: A historical fixed cohort study with dynamic follow-up time was conducted in 16,144 subjects aged 65 years and over, initiating antidepressant treatment and registered in the National Health Insurance Database between 2006 and 2012...
June 30, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27285799/assessment-of-the-real-life-usage-of-intravitreal-dexamethasone-implant-in-the-treatment-of-chronic-diabetic-macular-edema-in-france
#11
Giuseppe Querques, Fatemeh Darvizeh, Lea Querques, Vittorio Capuano, Francesco Bandello, Eric H Souied
PURPOSE: Intravitreal steroids, including dexamethasone implant (Ozurdex(®)), are effective for the treatment of diabetic macular edema (DME). However, the dosing regimen for Ozurdex in DME is unclear, and thus, this study was designed to evaluate the dosing regimen for dexamethasone in real-life clinical practice. METHODS: Results are presented from 3 studies based on a questionnaire that was sent out by e-mail to physicians; the monitoring of drugs dispensing over time through pharmacies; and the French Social Security database for 2011 and 2012...
July 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27283869/utilization-of-pharmacists-in-addressing-medication-abuse-in-the-pacific-northwest
#12
Duy Q Nguyen, Brian Chung, Loryn L Osburn, Mark A Della Paolera, Benjamin Chavez
OBJECTIVE: This article aims to explore the statistics observed in the Pacific Northwest regarding substance abuse, as Oregon and Washington have been shown to be most affected given the increased treatment admissions for opioid utilization and mortality related to medication overdose. METHODS: Using PubMed and National Conference of State Legislatures database, articles detailing prescription drug abuse statistics, programs, and laws were collected and analyzed in order to identify possible solutions...
June 9, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27264166/impact-of-prescription-drug-monitoring-programs-and-pill-mill-laws-on-high-risk-opioid-prescribers-a-comparative-interrupted-time-series-analysis
#13
Hsien-Yen Chang, Tatyana Lyapustina, Lainie Rutkow, Matthew Daubresse, Matt Richey, Mark Faul, Elizabeth A Stuart, G Caleb Alexander
BACKGROUND: Prescription drug monitoring programs (PDMPs) and pill mill laws were implemented to reduce opioid-related injuries/deaths. We evaluated their effects on high-risk prescribers in Florida. METHODS: We used IMS Health's LRx Lifelink database between July 2010 and September 2012 to identify opioid-prescribing prescribers in Florida (intervention state, N: 38,465) and Georgia (control state, N: 18,566). The pre-intervention, intervention, and post-intervention periods were: July 2010-June 2011, July 2011-September 2011, and October 2011-September 2012...
August 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27193822/fda-approved-drugs-that-interfere-with-laboratory-tests-a-systematic-search-of-us-drug-labels
#14
Hui Yao, Elizabeth R Rayburn, Qiang Shi, Liang Gao, Wenjie Hu, Haibo Li
Drug-related laboratory test interference or drug/laboratory test interactions (DLTI) are a major source of laboratory errors. DLTI is of concern with regard to both the clinical diagnosis and the monitoring of patients. Although there have been numerous reports about specific drugs that interfere with laboratory tests, there has not been a recent review on the topic. We herein provide a review of the known DLTI of US FDA-approved drugs based on a systematic search of DailyMed, a website containing the labels of US FDA-approved drugs...
June 27, 2016: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/27181079/prescription-drug-monitoring-programs-ethical-issues-in-the-emergency-department
#15
Catherine A Marco, Arvind Venkat, Eileen F Baker, John E Jesus, Joel M Geiderman
Prescription drug monitoring programs are statewide databases available to clinicians to track prescriptions of controlled medications. These programs may provide valuable information to assess the history and use of controlled substances and contribute to clinical decisionmaking in the emergency department (ED). The widespread availability of the programs raises important ethical issues about beneficence, nonmaleficence, respect for persons, justice, confidentiality, veracity, and physician autonomy. In this article, we review the ethical issues surrounding prescription drug monitoring programs and how those issues might be addressed to ensure the proper application of this tool in the ED...
November 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27167902/risperidone-induced-extrapyramidal-side-effects-is-the-need-for-anticholinergics-the-consequence-of-high-plasma-concentrations
#16
Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Gerhard Gründer, Benedikt Stegmann, Koen R J Schruers, Tanja Veselinovic, Sarah E Lammertz, Michael Paulzen
Antipsychotic drugs can induce various undesirable adverse motor reactions, such as extrapyramidal side effects (EPS). A widely accepted pharmacodynamic mechanism underlying EPS includes an increase in striatal D2-receptor occupancy. However, less is known about the pharmacokinetic background of EPS. The aim of this study was to analyze in-vivo possible pharmacokinetic patterns underlying biperiden-treated EPS in risperidone (RIS)-medicated patients. A large therapeutic drug monitoring database containing plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone (9-OH-RIS) of 2293 adult inpatients and outpatients was analyzed...
September 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27134536/clinical-relevancy-and-risks-of-potential-drug-drug-interactions-in-intensive-therapy
#17
Aline Teotonio Rodrigues, Rebeca Stahlschmidt, Silvia Granja, Antonio Luis Eiras Falcão, Patricia Moriel, Priscila Gava Mazzola
PURPOSE: Evaluate the potential Drug-Drug Interactions (pDDI) found in prescription orders of adult Intensive Care Unit (ICU) of a Brazilian public health system hospital; quantify and qualify the pDDI regarding their severity and risks to the critical patient, using the database from Micromedex®. METHODS: Prospective study (January-December of 2011) collecting and evaluating 369 prescription orders (convenient sampling), one per patient. RESULTS: During the study 1844 pDDIs were identified and distributed in 405 pairs (medication A × medication B combination)...
September 2015: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27084506/managing-inappropriate-use-of-non-prescription-combination-analgesics-containing-codeine-a-modified-delphi-study
#18
Amanda K Gibbins, Penelope J Wood, M Joy Spark
BACKGROUND: Misuse and/or dependence upon non-prescription combination analgesics containing codeine (NP-CACC) can result in serious physiological and psychological harms. OBJECTIVE: To explore pharmacists' and other health care professionals' ideas and views on strategies for managing NP-CACC misuse and/or dependence in a community pharmacy setting. METHODS: A 3-iteration modified Delphi study was conducted to gain the consensus view of panelists...
March 14, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27061342/characteristics-of-state-prescription-drug-monitoring-programs-a-state-by-state-survey
#19
A Travis Manasco, Christopher Griggs, Rebecca Leeds, Breanne K Langlois, Alan H Breaud, Patricia M Mitchell, Scott G Weiner
OBJECTIVES: Prescription drug monitoring programs (PDMPs) are state-based data collection systems recording controlled substance medications. Currently, 49 states have PDMPs. There are discrepancies in reporting patterns, infrastructure, and oversight between programs. We characterized aspects of each state's PDMP. METHODS: A web search of each state's PDMP was conducted, and a list of all PDMP administrators was obtained. From August 1 to November 31, 2014, a link to a web-based survey was sent to each PDMP administrator...
July 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27056579/benzodiazepine-use-misuse-and-harm-at-the-population-level-in-canada-a-comprehensive-narrative-review-of-data-and-developments-since-1995
#20
REVIEW
Yoko Murphy, Emily Wilson, Elliot M Goldner, Benedikt Fischer
Benzodiazepines are commonly prescribed psycho-pharmaceuticals (e.g., for anxiety, tension, and insomnia); they are generally considered safe but have potential adverse effects. Benzodiazepine use in Canada versus internationally is comparably high, yet no recent comprehensive review of use, misuse, or related (e.g., morbidity, mortality) harm at the population level exists; the present review aimed to fill this gap. We searched four key scientific literature databases (Medline, CINAHL, EBM Reviews, and Web of Science) with relevant search terms, and collected relevant "gray literature" (e...
July 2016: Clinical Drug Investigation
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