keyword
MENU ▼
Read by QxMD icon Read
search

Extreme longevity

keyword
https://www.readbyqxmd.com/read/27914849/age-related-variations-of-muscle-mass-strength-and-physical-performance-in-community-dwellers-results-from-the-milan-expo-survey
#1
Francesco Landi, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Domenico Fusco, Alex Sisto, Elena Ortolani, Giulia Savera, Sara Salini, Emanuele Marzetti
OBJECTIVES: Declining muscle mass and function are hallmarks of the aging process. The preservation of muscle trophism may protect against various negative health outcomes. Age- and sex-specific curves of muscle mass, strength, and function, using data from a large sample of community-dwelling people, are necessary. MATERIAL AND METHODS: Two surveys (Longevity Check-up and Very Important Protein [VIP]), conducted during EXPO 2015 in Milan, consisted of a population assessment aimed at evaluating the prevalence of specific health metrics in subjects outside of a research setting (n = 3206), with a special focus on muscle mass, strength, and function...
November 30, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27870990/memory-by-association-integrating-memories-prolongs-retention-by-two-year-olds
#2
Harlene Hayne, Julien Gross
Recalling one memory often leads to the recollection of other memories that share overlapping features. This phenomenon, spreading activation, was originally documented in studies conducted with verbal adults, and more recently, it has been demonstrated with preverbal infants. Here, we examine the effect of spreading activation on long-term retention by 2-year-olds. Participants were tested in the Visual Recognition Memory (VRM) paradigm and the deferred imitation paradigm. Typically, infants of this age exhibit retention in the VRM paradigm for 24h, while they exhibit retention in the deferred imitation paradigm for at least 8 weeks...
November 18, 2016: Infant Behavior & Development
https://www.readbyqxmd.com/read/27867213/screening-for-a-chronic-disease-a-multiple-stage-duration-model-with-partial-observability
#3
Thomas A Mroz, Gabriel Picone, Frank Sloan, Arseniy P Yashkin
We estimate a dynamic multi-stage duration model to investigate how early detection of diabetes can delay the onset of lower extremity complications and death. We allow for partial observability of the disease stage, unmeasured heterogeneity, and endogenous timing of diabetes screening. Timely diagnosis appears important. We evaluate the effectiveness of two potential policies to reduce the monetary costs of frequent screening in terms of lost longevity. Compared to the status quo, the more restrictive policy yields an implicit value for an additional year of life of about $50,000, while the less restrictive policy implies a value of about $120,000...
August 2016: International Economic Review
https://www.readbyqxmd.com/read/27863375/h2o2-treatment-or-serum-deprivation-induces-autophagy-and-apoptosis-in-naked-mole-rat-skin-fibroblasts-by-inhibiting-the-pi3k-akt-signaling-pathway
#4
Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cui
Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all increased the LC3-II/LC3-I ratio and numbers of double-membraned autophagosomes and autophagic vacuoles, and decreased levels of p70S6K, p-AktSer473, and p-AktThr308...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27861586/plastic-responses-contribute-to-explaining-altitudinal-and-temporal-variation-in-potential-flower-longevity-in-high-andean-rhodolirion-montanum
#5
Diego Andrés Pacheco, Leah S Dudley, Josefina Cabezas, Lohengrin A Cavieres, Mary T K Arroyo
The tendency for flower longevity to increase with altitude is believed by many alpine ecologists to play an important role in compensating for low pollination rates at high altitudes due to cold and variable weather conditions. However, current studies documenting an altitudinal increase in flower longevity in the alpine habitat derive principally from studies on open-pollinated flowers where lower pollinator visitation rates at higher altitudes will tend to lead to flower senescence later in the life-span of a flower in comparison with lower altitudes, and thus could confound the real altitudinal pattern in a species´ potential flower longevity...
2016: PloS One
https://www.readbyqxmd.com/read/27832764/blood-mirnomes-and-transcriptomes-reveal-novel-longevity-mechanisms-in-the-long-lived-bat-myotis-myotis
#6
Zixia Huang, David Jebb, Emma C Teeling
BACKGROUND: Chiroptera, the bats, are the only order of mammals capable of true self-powered flight. Bats exhibit a number of other exceptional traits such as echolocation, viral tolerance and, perhaps most puzzlingly, extreme longevity given their body size. Little is known about the molecular mechanisms driving their extended longevity particularly at the levels of gene expression and post-transcriptional regulation. To elucidate the molecular mechanisms that may underlie their unusual longevity, we have deep sequenced 246...
November 10, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27818232/the-genetics-of-exceptional-longevity-identifies-new-druggable-targets-for-vascular-protection-and-repair
#7
REVIEW
Annibale A Puca, Gaia Spinetti, Rosa Vono, Carmine Vecchione, Paolo Madeddu
Therapeutic angiogenesis is a relatively new medical strategy in the field of cardiovascular diseases. The underpinning concept is that angiogenic growth factors or proangiogenic cells could be exploited therapeutically in cardiovascular patients to enhance native revascularization responses to an ischemic insult, thereby accelerating tissue healing. The initial enthusiasm generated by preclinical studies has been tempered by the modest success of clinical trials assessing therapeutic angiogenesis. Similarly, proangiogenic cell therapy has so far not maintained the original promises...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27720058/facultative-social-insects-can-provide-insights-into-the-reversal-of-the-longevity-fecundity-trade-off-across-the-eusocial-insects
#8
Alice Séguret, Abel Bernadou, Robert J Paxton
In eusocial insects, reversal of the fecundity/longevity trade-off and extreme differences in life histories between castes of the same species garner scientific and public interest. Facultative social species at the threshold of sociality, in which individuals are socially plastic, provide an excellent opportunity to understand the causes and mechanisms underlying this reversal in life history trade-off associated with eusociality. We briefly present the ultimate factors favoring sociality and the association between fecundity and longevity in facultative eusocial insects, including kin selection and disposable soma, as well as proximate mechanisms observed in such species, such as differences in hormone titers and functions...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27720053/a-critical-look-at-proximate-causes-of-social-insect-senescence-damage-accumulation-or-hyperfunction
#9
Jane de Verges, Volker Nehring
Social insects have received attention for their extreme lifespan variation and reversal of the fecundity/longevity trade-off. However, proximate causes of senescence in general are disputed, and social insects often fail to meet the predictions of prevailing models. We present evidence for and against the long-held free radical theory of aging in social insects, and consider the application of the competing hyperfunction theory. Current results present problems for both theories, and a more complex picture of the biological processes involved emerges...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27720046/the-male-has-done-his-work-the-male-may-go
#10
Jürgen Heinze
Perennial social insects are famous for the extraordinary longevity of their queens. While the lifespan of termite kings matches those of queens, males of social Hymenoptera are usually considered to die after one or a few copulations. While this is true in species with highly synchronized nuptial flights, in others males mate over much longer periods. Male longevity is not correlated with the life span of queens but appears to be adapted to mating opportunities. This is demonstrated by the extreme life span of Cardiocondyla ant males, which monopolize mating with virgin queens over many months...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27714807/tiny-estimates-of-the-ne-n-ratio-in-marine-fishes-are-they-real
#11
R S Waples
Theory and empirical estimates agree that the ratio of effective size (Ne ) to census size (N) falls roughly in the range 0·1-0·5 for most populations. In a number of marine species, however, genetic estimates of contemporary Ne /N are as much as 5-6 orders of magnitude lower. Although some mechanisms that could produce such tiny Ne /N ratios have been proposed, the subject remains controversial. This issue is important to resolve: if Ne /N can be 10(-3) or smaller, marine fish populations that are quite large could be at genetic risk...
December 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27692712/genetic-changes-of-survival-traits-over-the-past-25-yr-in-dutch-dairy-cattle
#12
M L van Pelt, V Ducrocq, G de Jong, M P L Calus, R F Veerkamp
Genetic correlations and heritabilities for survival were investigated over a period of 25 yr to evaluate if survival in first lactation has become a different trait and if this is affected by adjusting for production level. Survival after first calving until 12 mo after calving (surv_12mo) and survival of first lactation (surv_1st_lac) were analyzed in Dutch black-and-white cows. The data set contained 1,108,745 animals for surv_12mo and 1,062,276 animals for surv_1st_lac, with first calving between 1989 and 2013...
September 28, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27692280/association-of-urinary-melatonin-levels-and-aging-related-outcomes-in-older-men
#13
Elizabeth E Devore, Stephanie L Harrison, Katie L Stone, Kathleen F Holton, Elizabeth Barrett-Connor, Sonia Ancoli-Israel, Kristine Yaffe, Kristine Ensrud, Peggy M Cawthon, Susan Redline, Eric Orwoll, Eva S Schernhammer
BACKGROUND: Circadian disruptions can contribute to accelerated aging, and the circadian system regulates cognitive and physical functions; therefore, circadian markers (eg, melatonin) may be associated with key aspects of healthy aging and longevity. OBJECTIVE: To evaluate urinary melatonin levels in relation to cognitive function, physical function, and mortality among 2,821 older men in the Osteoporotic Fractures in Men Study DESIGN: Cohort study. MEASUREMENTS: In 2003-2005, participants provided first-morning spot urine samples, which were assayed for 6-sulfatoxymelatonin (the primary melatonin metabolite in urine); cognitive and physical function assessments were completed twice, at baseline and an average of 6...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27672370/the-environmental-plasticity-of-diverse-body-color-caused-by-extremely-long-photoperiods-and-high-temperature-in-saccharosydne-procerus-homoptera-delphacidae
#14
Haichen Yin, Qihao Shi, Muhammad Shakeel, Jing Kuang, Jianhong Li
Melanization reflects not only body color variation but also environmental plasticity. It is a strategy that helps insects adapt to environmental change. Different color morphs may have distinct life history traits, e.g., development time, growth rate, and body weight. The green slender planthopper Saccharosydne procerus (Matsumura) is the main pest of water bamboo (Zizania latifolia). This insect has two color morphs. The present study explored the influence of photoperiod and its interaction with temperature in nymph stage on adult melanism...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27669377/effect-of-compositional-heterogeneity-on-dissolution-of-non-ideal-lnapl-mixtures
#15
M Vasudevan, C D Johnston, T P Bastow, G Lekmine, J L Rayner, I M Nambi, G Suresh Kumar, R Ravi Krishna, G B Davis
The extent of dissolution of petroleum hydrocarbon fuels into groundwater depends greatly on fuel composition. Petroleum fuels can consist of thousands of compounds creating different interactions within the non-aqueous phase liquid (NAPL), thereby affecting the relative dissolution of the components and hence a groundwater plume's composition over long periods. Laboratory experiments were conducted to study the variability in the effective solubilities and activity coefficients for common constituents of gasoline fuels (benzene, toluene, p-xylene and 1,2,4-trimethylbenzene) (BTX) in matrices with an extreme range of molar volumes and chemical affinities...
September 20, 2016: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27641541/reasons-for-success-rapid-evolution-for-desiccation-resistance-and-life-history-changes-in-the-polyphagous-fly-anastrepha-ludens
#16
Marco T Tejeda, José Arredondo, Pablo Liedo, Diana Pérez-Staples, Patricia Ramos-Morales, Francisco Díaz-Fleischer
Species that exhibit broad ranges of distribution may successfully navigate environmental changes by modifying some of their life-history traits. Environmental humidity imposes a critical stress that organisms may overcome by increasing their resistance to desiccation. We used experimental evolution to investigate adaptation to desiccation in the tephritid Anastrepha ludens, a species with high fecundity, late maturation, and long lifespan. We measured morphological, physiological, developmental as well as demographic changes involved in the adaptation to desiccation...
September 18, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27620821/-what-makes-some-rats-live-so-long-the-mitochondrial-contribution-to-longevity-through-balance-of-mitochondrial-dynamics-and-mtdna-content
#17
Anna Picca, Vito Pesce, Giuseppe Sirago, Flavio Fracasso, Christiaan Leeuwenburgh, Angela Maria Serena Lezza
Extremely interesting for aging research are those individuals able to reach older ages still with functions similar to those of younger counterparts. We examined liver samples from ad libitum-fed old (28-month-old, AL-28) and ad libitum-fed very old (32-month-old, AL-32) rats for a number of markers, relevant for mitochondrial functionality and mitochondrial DNA (mtDNA) content. As for the mtDNA content and the protein amounts of the citrate synthase and the antioxidant peroxiredoxin III there were no significant changes in the AL-32 animals...
September 13, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27595500/aging-of-the-immune-system-focus-on-inflammation-and-vaccination
#18
Marcello Pinti, Victor Appay, Judith Campisi, Daniela Frasca, Tamas Fülöp, Delphine Sauce, Anis Larbi, Birgit Weinberger, Andrea Cossarizza
Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the underlying cause of the disparate pathologies occurring in the elderly: aging itself. The identification of the basis of the aging processes that drives the multiple pathologies and loss of function typical of older individuals is a major challenge in current aging research...
October 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27590044/neuropathology-of-supercentenarians-four-autopsy-case-studies
#19
Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura
Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27573004/polyandry-increases-reproductive-performance-but-does-not-decrease-survival-in-female-brontispa-longissima
#20
K Kawazu, W Sugeno, A Mochizuki, S Nakamura
The costs and benefits of polyandry are still not well understood. We studied the effects of multiple mating on the reproductive performance of female Brontispa longissima (Coleoptera: Chrysomelidae), one of the most serious pests of the coconut palm, by using three experimental treatments: (1) singly-mated females (single treatment); (2) females that mated 10 times with the same male (repetition treatment); and (3) females that mated once with each of 10 different males (polyandry treatment). Both multiple mating treatments resulted in significantly greater total egg production and the proportion of eggs that successfully hatched (hatching success) than with the single mating treatment...
August 30, 2016: Bulletin of Entomological Research
keyword
keyword
106438
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"