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Extreme longevity

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https://www.readbyqxmd.com/read/28797827/interaction-between-mtor-pathway-inhibition-and-autophagy-induction-attenuates-adriamycin-induced-vascular-smooth-muscle-cell-senescence-through-decreased-expressions-of-p53-p21-p16
#1
Jin Young Sung, Kyung Young Lee, Jae-Ryong Kim, Hyoung Chul Choi
Cellular senescence is related to aging and extremely stable proliferative arrest with active metabolism. Senescent cells can activate mammalian target of rapamycin (mTOR) pathway, which plays a crucial role in the regulation of cell metabolism, cellular growth, and autophagy in senescence-associated cardiovascular diseases. Therefore, we examined whether mTOR pathway could induce cellular senescence by inhibition of autophagy in vascular smooth muscle cells (VSMCs). We found that adriamycin-induced VSMC senescence is accompanied by increased activity of mTOR, a major controller of cell growth and a negative regulator of autophagy...
August 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28753971/spatio-temporal-variation-of-longevity-clusters-and-the-influence-of-social-development-level-on-lifespan-in-a-chinese-longevous-area-1982-2010
#2
Jian Qin, Guoqi Yu, Tianlong Xia, You Li, Xue Liang, Peng Wei, Bingshuang Long, Mingzhi Lei, Xiao Wei, Xianyan Tang, Zhiyong Zhang
The study aims to determine the spatial and temporal variation of a longevous region and explore the correlation between longevity and socioeconomic development. Population data at the township level were obtained from the last four population censuses (1982-2010). Five main lifespan indicators and the Human Development Index (HDI) were calculated. Getis-Ord G*, Gravity modeling, and Pearson's r between lifespan indicators and HDI were applied. In this study, a stable longevous gathering area was discovered in Hechi during different periods...
July 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28734548/ubiquitin-like-modifications-in-the-dna-damage-response
#3
REVIEW
Zhifeng Wang, Wei-Guo Zhu, Xingzhi Xu
Genomic DNA is damaged at an extremely high frequency by both endogenous and environmental factors. An improper response to DNA damage can lead to genome instability, accelerate the aging process and ultimately cause various human diseases, including cancers and neurodegenerative disorders. The mechanisms that underlie the cellular DNA damage response (DDR) are complex and are regulated at many levels, including at the level of post-translational modification (PTM). Since the discovery of ubiquitin in 1975 and ubiquitylation as a form of PTM in the early 1980s, a number of ubiquitin-like modifiers (UBLs) have been identified, including small ubiquitin-like modifiers (SUMOs), neural precursor cell expressed, developmentally down-regulated 8 (NEDD8), interferon-stimulated gene 15 (ISG15), human leukocyte antigen (HLA)-F adjacent transcript 10 (FAT10), ubiquitin-fold modifier 1 (UFRM1), URM1 ubiquitin-related modifier-1 (URM1), autophagy-related protein 12 (ATG12), autophagy-related protein 8 (ATG8), fan ubiquitin-like protein 1 (FUB1) and histone mono-ubiquitylation 1 (HUB1)...
July 11, 2017: Mutation Research
https://www.readbyqxmd.com/read/28707767/if-why-and-when-subjective-well-being-influences-health-and-future-needed-research
#4
Ed Diener, Sarah D Pressman, John Hunter, Desiree Delgadillo-Chase
We review evidence on whether subjective well-being (SWB) can influence health, why it might do so, and what we know about the conditions where this is more or less likely to occur. This review also explores how various methodological approaches inform the study of the connections between subjective well-being and health and longevity outcomes. Our review of this growing literature indicates areas where data are substantial and where much more research is needed. We conclude that SWB can sometimes influence health, and review a number of reasons why it does so...
July 2017: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/28699149/is-the-clavicula-pro-humero-technique-of-value-for-reconstruction-after-resection-of-the-proximal-humerus-in-children
#5
Dominique Barbier, Benoît De Billy, Philippe Gicquel, Sophie Bourelle, Pierre Journeau
BACKGROUND: There are several options for reconstruction of proximal humerus resections after wide resection for malignant tumors in children. The clavicula pro humero technique is a biologic option that has been used in the past, but there are only scant case reports and small series that comment on the results of the procedure. Because the longevity of children mandates a reconstruction with potential longevity not likely to be achieved by other techniques, the clavicula pro humero technique may be a potential option in selected patients...
July 11, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28689349/extreme-longevity-in-a-deep-sea-vestimentiferan-tubeworm-and-its-implications-for-the-evolution-of-life-history-strategies
#6
Alanna Durkin, Charles R Fisher, Erik E Cordes
The deep sea is home to many species that have longer life spans than their shallow-water counterparts. This trend is primarily related to the decline in metabolic rates with temperature as depth increases. However, at bathyal depths, the cold-seep vestimentiferan tubeworm species Lamellibrachia luymesi and Seepiophila jonesi reach extremely old ages beyond what is predicted by the simple scaling of life span with body size and temperature. Here, we use individual-based models based on in situ growth rates to show that another species of cold-seep tubeworm found in the Gulf of Mexico, Escarpia laminata, also has an extraordinarily long life span, regularly achieving ages of 100-200 years with some individuals older than 300 years...
August 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28649103/-aging-and-homeostasis-biomedical-peculiarities-of-semi-supercentenarians
#7
Yasumichi Arai
Semi-supercentenarians, or people who reach 105 years of age, are regarded as model cases for 'successful ageing'. Semi-supercentenarians maintain capability and cognition for longer than the centenarians who died between 100-104 years of age, together with postponed frailty or age-related diminution of multiple organ reserve. Understanding the biological factors determining extreme longevity and compression of morbidity might help to achieve extended healthy life span for the wider population.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28646299/effective-combined-water-and-sideband-suppression-for-low-speed-tissue-and-in-vivo-mas-nmr
#8
Yalda Liaghati Mobarhan, Jochem Struppe, Blythe Fortier-McGill, André J Simpson
High-resolution magic angle spinning (HR-MAS) NMR is a powerful technique that can provide metabolic profiles and structural constraints on intact biological and environmental samples such as cells, tissues and living organisms. However, centripetal force from fast spinning can lead to a loss of sample integrity. In analyses focusing on structural organization, metabolite compartmentalization or in vivo studies, it is critical to keep the sample intact. As such, there is growing interest in slow spinning studies that preserve sample longevity...
August 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28637252/wheat-seed-weight-and-quality-differ-temporally-in-sensitivity-to-warm-or-cool-conditions-during-seed-development-and-maturation
#9
M Nasehzadeh, R H Ellis
Background and aims: Short periods of extreme temperature may affect wheat ( Triticum aestivum ) seed weight, but also quality. Temporal sensitivity to extreme temperature during seed development and maturation was investigated. Methods: Plants of 'Tybalt' grown at ambient temperature were moved to growth cabinets at 29/20 °C or 34/20 °C (2010), or 15/10 °C or 34/20 °C (2011), for successive 7-d periods from 7 DAA (days after anthesis) onwards, and also 7-65 DAA in 2011...
June 15, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28601155/boar-genotype-as-a-factor-shaping-age-related-changes-in-semen-parameters-and-reproduction-longevity-simulations
#10
Damian Knecht, Anna Jankowska-Mąkosa, Kamil Duziński
The aim of this study was a detailed analysis of the boar genotypes used in AI stations with an indication of their production capacity, including age and a precise analysis of their culling time and reason. The study included 334 boars: 81 Polish Large White (PLW), 108 Polish Landrace (PL), 49 Pietrain (P), 56 Duroc × Pietrain (D × P) and 40 Hampshire × Pietrain (H × P). Semen volume, spermatozoa concentration, total number of spermatozoa, number of motile spermatozoa, and number of insemination doses were analyzed...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28599250/evaluation-of-mir-15a-and-mir-16-1-as-prognostic-biomarkers-in-chronic-lymphocytic-leukemia
#11
REVIEW
Tatiane Vieira Braga, Fernanda Cristina Gontijo Evangelista, Lorena Caixeta Gomes, Sérgio Schusterschitz da Silva Araújo, Maria das Graças Carvalho, Adriano de Paula Sabino
Chronic lymphocytic leukemia (CLL) is a B lineage neoplasm, characterized by the accumulation of B lymphocytes of great longevity, and usually develops as a result of the inhibition of apoptosis. Clinical evolution is extremely variable amongst affected individuals with survival ranging from a few months in aggressive cases, to a few decades in cases of indolent CLL. The identification of new prognostic factors, apart from clinical staging, has been an important research topic aiming at a better understanding of CLL...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28587826/safety-assessment-of-cultivated-fruiting-body-of-ophiocordyceps-sinensis-evaluated-through-subacute-toxicity-in-rats
#12
Shin Yee Fung, Sook Shien Lee, Nget Hong Tan, Jayalakshmi Pailoor
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (Berk.) G.H. Sung, J.M. Sung, Hywel-Jones & Spatafora is one of the most renowned traditional Chinese medicine used as tonic, renal, respiratory and reproductive health, promote longevity and overall improvement in quality of life. Natural production of O. sinensis is limited due to its extreme specificity in host range and confined geographic distribution. Therefore, cultivation of the fungus was developed to meet high demand for commercialization as nutraceutical...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28510785/the-impact-of-leisure-on-mental-health-of-sardinian-elderly-from-the-blue-zone-evidence-for-ageing-well
#13
Maria Chiara Fastame, Paul Kenneth Hitchcott, Maria Pietronilla Penna
BACKGROUND: There has been scientific interest in the Sardinia population for a number of years and for a variety of reasons, including its extreme longevity. This is especially prevalent in the central-eastern region of the island, where a blue zone region has been precisely delineated. AIMS: The present study examines the influence of leisure activities on psychological well-being and depressive symptoms in elderly individuals living in the blue zone region of inner Sardinia...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28499251/sequestration-of-polyunsaturated-fatty-acids-in-membrane-phospholipids-of-caenorhabditis-elegans-dauer-larva-attenuates-eicosanoid-biosynthesis-for-prolonged-survival
#14
Sin Man Lam, Zehua Wang, Jie Li, Xun Huang, Guanghou Shui
Mechanistic basis governing the extreme longevity and developmental quiescence of dauer juvenile, a "non-ageing" developmental variant of Caenorhabditis elegans, has remained largely obscure. Using a lipidomic approach comprising multiple reaction monitoring transitions specific to distinct fatty acyl moieties, we demonstrated that in comparison to other developmental stages, the membrane phospholipids of dauer larva contain a unique enrichment of polyunsaturated fatty acids (PUFAs). Esterified PUFAs in phospholipids exhibited temporal accumulation throughout the course of dauer endurance, followed by sharp reductions prior to termination of diapause...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28461103/demographic-genetic-and-phenotypic-characteristics-of-centenarians-in-italy-focus-on-gender-differences
#15
REVIEW
Alberto Montesanto, Francesco De Rango, Chiara Pirazzini, Giulia Guidarelli, Filippo Domma, Claudio Franceschi, Giuseppe Passarino
An impressive and coherent series of epidemiological data from different populations (New England Americans, Mormons, Ashkenazi Jewish, Icelandic, Okinawan Japanese, Italians) suggests that long-lived subjects able to reach the extreme limits of human life, such as centenarians and supercentenarians, represent an extraordinary and informative model to identify the mechanisms responsible for healthy aging and human longevity. In most studies, genetic, demographic and phenotypic characteristics of longevity are discussed separately...
April 28, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28458014/positive-diversifying-selection-is-a-pervasive-adaptive-force-throughout-the-drosophila-radiation
#16
Francesco Cicconardi, Paolo Marcatili, Wolfgang Arthofer, Birgit C Schlick-Steiner, Florian M Steiner
The growing genomic information on non-model organisms eases exploring the evolutionary history of biodiversity. This is particularly true for Drosophila flies, in which the number of sequenced species doubled recently. Because of its outstanding diversity of species, Drosophila has become one of the most important systems to study adaptive radiation. In this study, we performed a genome-wide analysis of positive diversifying selection on more than 2000 single-copy orthologous groups in 25 species using a recent method of increased accuracy for detecting positive diversifying selection...
April 27, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28432393/more-functions-of-torpor-and-their-roles-in-a-changing-world
#17
Julia Nowack, Clare Stawski, Fritz Geiser
Increased winter survival by reducing energy expenditure in adult animals is often viewed as the primary function of torpor. However, torpor has many other functions that ultimately increase the survival of heterothermic mammals and birds. In this review, we summarize new findings revealing that animals use torpor to cope with the conditions during and after natural disasters, including fires, storms, and heat waves. Furthermore, we suggest that torpor, which also prolongs longevity and was likely crucial for survival of mammals during the time of the dinosaur extinctions, will be advantageous in a changing world...
July 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28359014/sperm-motility-activation-in-the-critically-endangered-booroolong-frog-the-effect-of-medium-osmolality-and-phosphodiesterase-inhibitors
#18
Aimee J Silla, Leesa M Keogh, Phillip G Byrne
Effective activation of sperm motility is fundamental to successful artificial fertilisation; however, studies investigating optimal procedures in amphibians are lacking. This study found the optimal osmolality of activation media for sperm motility activation and evaluated the effect of phosphodiesterase (PDE) inhibitors on sperm activation and longevity in the critically endangered booroolong frog, Litoria booroolongensis. To assess the effect of medium osmolality (10, 25, 50, 75, 100 and 200mOsmolkg-1) and PDE inhibitors (control, 2...
March 31, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28329165/four-genome-wide-association-studies-identify-new-extreme-longevity-variants
#19
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T Perls
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to discover longevity-associated variants (LAV) and characterized those LAVs that differentiate survival to extreme age at death (eSAVs) from those LAVs that become more frequent in centenarians because of mortality selection (eg, survival to younger years)...
March 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#20
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
June 2017: American Journal of Sports Medicine
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