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https://www.readbyqxmd.com/read/29590466/beyond-one-hundred-a-cohort-analysis-of-italian-centenarians-and-semi-supercentenarians
#1
Graziella Caselli, Marco Battaglini, Giorgia Capacci
Although the increase in the number of centenarians is well documented today in countries with advanced demographic data, the same is not true for those aged 105 and over. The first aim of this paper, was to analyze the demographic characteristics of the 4,626 validated semi-super and 102 supercentenarians for the cohorts born between 1896 and 1910, referring to Italian Semi-Supercentenarians Survey (SSC). Then, starting from this data and from the survival  histories  in old ages - reconstructed by Vincent's Extinct - Cohort Method - for the cohorts born between 1870 and 1904, the most important aim was to analyze longevity history and the trend of gender gap of the Italian oldest cohorts beyond 100 years old...
March 26, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29580922/characteristic-glycopeptides-associated-with-extreme-human-longevity-identified-through-plasma-glycoproteomics
#2
Yuri Miura, Noritaka Hashii, Yuki Ohta, Yoko Itakura, Hiroki Tsumoto, Junya Suzuki, Daisuke Takakura, Yukiko Abe, Yasumichi Arai, Masashi Toyoda, Nana Kawasaki, Nobuyoshi Hirose, Tamao Endo
BACKGROUND: Glycosylation is highly susceptible to changes of the physiological conditions, and accordingly, is a potential biomarker associated with several diseases and/or longevity. Semi-supercentenarians (SSCs; older than 105 years) are thought to be a model of human longevity. Thus, we performed glycoproteomics using plasma samples of SSCs, and identified proteins and conjugated N-glycans that are characteristic of extreme human longevity. METHODS: Plasma proteins from Japanese semi-supercentenarians (SSCs, 106-109 years), aged controls (70-88 years), and young controls (20-38 years) were analysed by using lectin microarrays and liquid chromatography/mass spectrometry (LC/MS)...
March 24, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29562544/aging-without-dementia-is-achievable-current-evidence-from-epidemiological-research
#3
Chengxuan Qiu, Laura Fratiglioni
Both the incidence and the prevalence of dementia increase exponentially with increasing age. This raises the question of whether dementia is an inevitable consequence of aging or whether aging without dementia is achievable. In this review article, we sought to summarize the current evidence from epidemiological and neuropathological studies that investigated this topic. Epidemiological studies have shown that dementia could be avoided even at extreme old ages (e.g., centenarians or supercentenarians). Furthermore, clinico-neuropathological studies found that nearly half of centenarians with dementia did not have sufficient brain pathology to explain their cognitive symptoms, while intermediate-to-high Alzheimer pathology was present in around one-third of very old people without dementia or cognitive impairment...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29390945/validated-living-worldwide-supercentenarians-living-and-recently-deceased-february-2018
#4
Robert D Young
No abstract text is available yet for this article.
February 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29170764/mortality-trajectories-at-exceptionally-high-ages-a-study-of-supercentenarians
#5
Natalia S Gavrilova, Leonid A Gavrilov, Vyacheslav N Krut'ko
The growing number of persons surviving to age 100 years and beyond raises questions about the shape of mortality trajectories at exceptionally high ages, and this problem may become significant for actuaries in the near future. However, such studies are scarce because of the difficulties in obtaining reliable age estimates at exceptionally high ages. The current view about mortality beyond age 110 years suggests that death rates do not grow with age and are virtually flat. The same assumption is made in the new actuarial VBT tables...
January 2017: Living to 100 Monograph
https://www.readbyqxmd.com/read/28904969/sociodemographic-and-clinical-characteristics-of-centenarians-in-mexico-city
#6
Valdés-Corchado Pedro, Ruiz-Hernández Arturo, Pérez-Moreno Alejandro, Rosas-Carrasco Oscar
BACKGROUND: There is little evidence about the demography and health status of adults aged 100 years and over in Latin America and there are no studies in Mexico. OBJECTIVES: To describe the demographic characteristics and health status of centenarians residing in Mexico City. METHODS: This is a cross-sectional study using a population base of 393 community-dwelling centenarians in Mexico City. A comprehensive geriatric assessment was performed, including demographic information and health status...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28649103/-aging-and-homeostasis-biomedical-peculiarities-of-semi-supercentenarians
#7
Yasumichi Arai
Semi-supercentenarians, or people who reach 105 years of age, are regarded as model cases for 'successful ageing'. Semi-supercentenarians maintain capability and cognition for longer than the centenarians who died between 100-104 years of age, together with postponed frailty or age-related diminution of multiple organ reserve. Understanding the biological factors determining extreme longevity and compression of morbidity might help to achieve extended healthy life span for the wider population.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28461103/demographic-genetic-and-phenotypic-characteristics-of-centenarians-in-italy-focus-on-gender-differences
#8
REVIEW
Alberto Montesanto, Francesco De Rango, Chiara Pirazzini, Giulia Guidarelli, Filippo Domma, Claudio Franceschi, Giuseppe Passarino
An impressive and coherent series of epidemiological data from different populations (New England Americans, Mormons, Ashkenazi Jewish, Icelandic, Okinawan Japanese, Italians) suggests that long-lived subjects able to reach the extreme limits of human life, such as centenarians and supercentenarians, represent an extraordinary and informative model to identify the mechanisms responsible for healthy aging and human longevity. In most studies, genetic, demographic and phenotypic characteristics of longevity are discussed separately...
July 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28214534/demographic-phenotypic-and-genetic-characteristics-of-centenarians-in-okinawa-and-honshu-japan-part-2-honshu-japan
#9
REVIEW
Yasumichi Arai, Takashi Sasaki, Nobuyoshi Hirose
The scope and purpose of this review was to summarize the aims, methods, findings, and future of centenarian and (semi)-supercentenarian studies in Japan, particularly those from our own interdisciplinary laboratory. Medically, approximately 97% of centenarians contract chronic diseases including hypertension and gastrointestinal disease; however, they present with few cardiovascular risk factors. The low prevalence of diabetes mellitus and carotid atherosclerotic plaques is peculiarities of centenarians, which could be associated with high adiponectin levels...
July 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28125934/validated-living-worldwide-supercentenarians
#10
Robert D Young
No abstract text is available yet for this article.
February 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28038993/inflammaging-and-human-longevity-in-the-omics-era
#11
REVIEW
Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi
Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omics data - particularly on glycomics - collected on centenarians, semi-supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli defined "molecular garbage"; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a "local fire", which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly informative set/combination of omics markers able to better grasp the complex molecular core of inflammaging in elderly and centenarians...
July 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27861536/muscle-related-polymorphisms-mstn-rs1805086-and-actn3-rs1815739-are-not-associated-with-exceptional-longevity-in-japanese-centenarians
#12
Noriyuki Fuku, Rafael Alis, Thomas Yvert, Hirofumi Zempo, Hisashi Naito, Yukiko Abe, Yasumichi Arai, Haruka Murakami, Motohiko Miyachi, Helios Pareja-Galeano, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical...
2016: PloS One
https://www.readbyqxmd.com/read/27590044/neuropathology-of-supercentenarians-four-autopsy-case-studies
#13
Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura
Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders...
September 2, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27282794/the-genetics-of-exceptional-longevity-insights-from-centenarians
#14
REVIEW
Alejandro Santos-Lozano, Ana Santamarina, Helios Pareja-Galeano, Fabian Sanchis-Gomar, Carmen Fiuza-Luces, Carlos Cristi-Montero, Aranzazu Bernal-Pino, Alejandro Lucia, Nuria Garatachea
As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs)...
August 2016: Maturitas
https://www.readbyqxmd.com/read/27185560/gut-microbiota-and-extreme-longevity
#15
Elena Biagi, Claudio Franceschi, Simone Rampelli, Marco Severgnini, Rita Ostan, Silvia Turroni, Clarissa Consolandi, Sara Quercia, Maria Scurti, Daniela Monti, Miriam Capri, Patrizia Brigidi, Marco Candela
The study of the extreme limits of human lifespan may allow a better understanding of how human beings can escape, delay, or survive the most frequent age-related causes of morbidity, a peculiarity shown by long-living individuals. Longevity is a complex trait in which genetics, environment, and stochasticity concur to determine the chance to reach 100 or more years of age [1]. Because of its impact on human metabolism and immunology, the gut microbiome has been proposed as a possible determinant of healthy aging [2, 3]...
June 6, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/26678252/decreased-epigenetic-age-of-pbmcs-from-italian-semi-supercentenarians-and-their-offspring
#16
Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Given the dramatic increase in ageing populations, it is of great importance to understand the genetic and molecular determinants of healthy ageing and longevity. Semi-supercentenarians (subjects who reached an age of 105-109 years) arguably represent the gold standard of successful human ageing because they managed to avoid or postpone the onset of major age-related diseases. Relatively few studies have looked at epigenetic determinants of extreme longevity in humans. Here we test whether families with extreme longevity are epigenetically distinct from controls according to an epigenetic biomarker of ageing which is known as "epigenetic clock"...
December 2015: Aging
https://www.readbyqxmd.com/read/26629551/inflammation-but-not-telomere-length-predicts-successful-ageing-at-extreme-old-age-a-longitudinal-study-of-semi-supercentenarians
#17
Yasumichi Arai, Carmen M Martin-Ruiz, Michiyo Takayama, Yukiko Abe, Toru Takebayashi, Shigeo Koyasu, Makoto Suematsu, Nobuyoshi Hirose, Thomas von Zglinicki
To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99 years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains...
October 2015: EBioMedicine
https://www.readbyqxmd.com/read/26443251/genetic-investigation-of-an-iranian-supercentenarian-by-whole-exome-sequencing
#18
Tara Akhtarkhavari, Mohammad Taghi Joghataei, Zohreh Fattahi, Mohammad Reza Akbari, Farzaneh Larti, Hossein Najmabadi, Kimia Kahrizi
BACKGROUND: The genetic basis of longevity is an important field of study because the majority of supercentenarian cases experience healthy aging and may only show age-related diseases in their last few years of life. It is clear that genetic factors play an important role in survival beyond 90 years of age, but the exact relationship of genetic variants to this phenomenon remains unknown. OBJECTIVE: The aim of this project was to investigate different hypotheses that describe the relationship between genetic variants and human longevity in a living Iranian man by Whole Exome Sequencing...
October 2015: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/26402023/unilateral-spinal-anesthesia-experience-in-a-supercentenarian
#19
Fadime Tosun, Metehan Ozen, Cihad Tatar, Huseyin Alakus
Improvement of living and socioeconomic conditions, developments, and innovations in medicine and technology has prolonged of life expectancy. We provided spinal anesthesia for a 111-year-old woman requiring internal fixation of a fractured femur. The operation lasted 75 minutes. After surgery, the patient was monitored in the intensive care unit overnight. The patient was discharged from the intensive care unit after 24-hour monitoring without any complications. She was discharged from the hospital on postoperative day 2...
October 1, 2015: A & A Case Reports
https://www.readbyqxmd.com/read/26000617/the-cerebellum-ages-slowly-according-to-the-epigenetic-clock
#20
Steve Horvath, Vei Mah, Ake T Lu, Jennifer S Woo, Oi-Wa Choi, Anna J Jasinska, José A Riancho, Spencer Tung, Natalie S Coles, Jonathan Braun, Harry V Vinters, L Stephen Coles
Studies that elucidate why some human tissues age faster than others may shed light on how we age, and ultimately suggest what interventions may be possible. Here we utilize a recent biomarker of aging (referred to as epigenetic clock) to assess the epigenetic ages of up to 30 anatomic sites from supercentenarians (subjects who reached an age of 110 or older) and younger subjects. Using three novel and three published human DNA methylation data sets, we demonstrate that the cerebellum ages more slowly than other parts of the human body...
May 2015: Aging
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