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https://www.readbyqxmd.com/read/28435840/microbial-flora-probiotics-bacillus-subtilis-and-the-search-for-a-long-and-healthy-human-longevity
#1
COMMENT
Facundo Rodriguez Ayala, Carlos Bauman, Sebastián Cogliati, Cecilia Leñini, Marco Bartolini, Roberto Grau
Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming probiotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity...
March 16, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28422270/characteristics-and-incidence-of-chronic-illness-in-community-dwelling-predominantly-male-u-s-veteran-centenarians
#2
Raya Elfadel Kheirbek, Ali Fokar, Nawar Shara, Leakie K Bell-Wilson, Hans J Moore, Edwin Olsen, Marc R Blackman, Maria D Llorente
OBJECTIVES: To assess the incidence of chronic illness and its effect on veteran centenarians. DESIGN: Retrospective longitudinal cohort study. SETTING: United States Veterans Affairs Corporate Data Warehouse (CDW). PARTICIPANTS: Community-dwelling veterans born between 1910 and 1915 who survived to at least age 80 (N = 86,892; 31,121 octogenarians, 52,420 nonagenarians, 3,351 centenarians). MEASUREMENTS: The Kaplan-Meier method was used to estimate cumulative incidence of chronic conditions according to age group...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28419892/plasma-apolipoproteins-and-physical-and-cognitive-health-in-very-old-individuals
#3
Julia Muenchhoff, Fei Song, Anne Poljak, John D Crawford, Karen A Mather, Nicole A Kochan, Zixuan Yang, Julian N Trollor, Simone Reppermund, Kate Maston, Adam Theobald, Susanne Kirchner-Adelhardt, John B Kwok, Robyn L Richmond, Mark McEvoy, John Attia, Peter W Schofield, Henry Brodaty, Perminder S Sachdev
Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease, and longevity. We quantified 7 apolipoproteins in plasma in 1067 individuals aged 56-105 using immunoassays and explored relationships with APOE polymorphism ε2/3/4, vascular health, frailty, and cognition. ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH, and ApoJ decreased from mid-life, although ApoE and ApoJ had U-shaped trends. Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups...
March 1, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28417136/too-old-for-surgery-outcomes-of-hip-fracture-surgery-in-centenarians
#4
Wei Xiang Ng, Ernest Bk Kwek
No abstract text is available yet for this article.
March 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28388449/assessment-of-elemental-background-values-and-their-relation-with-lifespan-indicators-a-comparative-study-of-jining-in-shandong-province-and-guanzhong-area-in-shaanxi-province-northern-china
#5
Shaobin Wang, Kunli Luo, Runxiang Ni, Yuan Tian, Xing Gao
The remarkably high proportions of centenarians are found in the Jining Prefecture in southwestern Shandong province, demonstrating remarkable regional longevity differentiation. In this paper, census data at county-level, samples of drinking water and staple grains in Jining Prefecture were collected. Guanzhong area in Shaanxi Province, a non-longevity region in northern China was chosen as the contrast area. The major and trace elements in the samples were determined by using ICP-MS, ICP-OES and HG-AFS. The major results show that Jinxiang County in Jining Prefecture exhibit obviously higher longevity level than adjacent counties and Chinese average level based on temporal and spatial variation of lifespan indicators...
April 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28378616/effect-of-life-events-social-supports-and-personality-on-mental-status-in-later-life
#6
Kyuho Lee, Marissa Holst, Peter Martin, Leonard W Poon
The goal of this study was to explore the influences of proximal and distal life events on mental status in later life. Additionally, life events were categorized into positive and negative experiences. Data from 208 older adults over 80 years of age from the Georgia Centenarian Study were included in this study. Results from a series of blockwise regression analyses indicated that the number of distal negative life events that older adults had experienced was a predictor of older adults' better mental status...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28329165/four-genome-wide-association-studies-identify-new-extreme-longevity-variants
#7
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T Kraja, Danny Ben-Avraham, Nir Barzilai, Annibale Puca, Thomas T Perls
The search for the genetic determinants of extreme human longevity has been challenged by the phenotype's rarity and its nonspecific definition by investigators. To address these issues, we established a consortium of four studies of extreme longevity that contributed 2,070 individuals who survived to the oldest one percentile of survival for the 1900 U.S. birth year cohort. We conducted various analyses to discover longevity-associated variants (LAV) and characterized those LAVs that differentiate survival to extreme age at death (eSAVs) from those LAVs that become more frequent in centenarians because of mortality selection (eg, survival to younger years)...
March 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28315698/worldwide-demography-of-centenarians
#8
REVIEW
Jean-Marie Robine, Sarah Cubaynes
The global number of centenarians should strongly increase during the 21 st century. According to the Population Division of the United Nations it should reach more than 25 million people in 2100. To better understand the dynamics of the emergence and growth of the centenarian population, we focused on four European countries having long chronological series and high quality data about centenarians, Denmark, France, Sweden, and Switzerland, and Japan which has had the highest life expectancy at birth for several years...
March 15, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28286215/thyroid-hormones-in-extreme-longevity
#9
REVIEW
Sabrina Garasto, Alberto Montesanto, Andrea Corsonello, Fabrizia Lattanzio, Sergio Fusco, Giuseppe Passarino, Valeria Prestipino Giarritta, Francesco Corica
The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges...
March 9, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28286214/cognitive-status-in-the-oldest-old-and-centenarians-a-condition-crucial-for-quality-of-life-methodologically-difficult-to-assess
#10
REVIEW
Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti
Human life expectancy and the number of the oldest old are rapidly increasing worldwide. Advanced age is the main risk factor for dementia, representing one of the major causes of disability/dependency among older people with a strong impact on their families/caregivers. Centenarians have reached the extreme limits of human life escaping or delaying the major age-related diseases. Thus, these extraordinary individuals embody the best model to answer the crucial question if cognitive decline and dementia are progressive and unavoidable occurrences of increasing age...
March 9, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28281568/the-adhesion-of-lactobacillus-salivarius-ren-to-a-human-intestinal-epithelial-cell-line-requires-s-layer-proteins
#11
Ran Wang, Lun Jiang, Ming Zhang, Liang Zhao, Yanling Hao, Huiyuan Guo, Yue Sang, Hao Zhang, Fazheng Ren
Lactobacillus salivarius REN, a novel probiotic isolated from Chinese centenarians, can adhere to intestinal epithelial cells and subsequently colonize the host. We show here that the surface-layer protein choline-binding protein A (CbpA) of L. salivarius REN was involved in adherence to the human colorectal adenocarcinoma cell line HT-29. Adhesion of a cbpA deletion mutant was significantly reduced compared with that of wild-type, suggesting that CbpA acts as an adhesin that mediates the interaction between the bacterium and its host...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276619/hospital-admissions-by-the-oldest-old-past-trends-in-one-of-the-most-ageing-countries-in-the-world
#12
Daniela Brandão, Oscar Ribeiro, Alberto Freitas, Constança Paúl
AIM: To examine discharges of octogenarians, nonagenarians and centenarians from Portuguese public hospitals, namely admission type, principal diagnoses, comorbidities and length of stay. METHODS: The present study used administrative data from public acute care hospitals in the Portuguese National Health Service. All discharges of persons aged ≥80 years between 2000 and 2014 were analyzed. HCUP Clinical Classifications Software was considered to aggregate principal diagnosis, and comorbidities were assessed using the Charlson Comorbidity Index computed using International Classification of Diseases 9th Revision Clinical Modification codes...
March 9, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28260154/the-cost-and-mortality-of-hip-fractures-in-centenarians
#13
J Moore, O Carmody, B Carey, J A Harty, D Reidy
BACKGROUND: Centenarians are the fastest rising age group in Ireland. Hip fractures most commonly affect older adults and are associated with significant morbidity and mortality, as well as the financial cost of healthcare resources. Despite this, very little is known regarding hip fractures in centenarians. The aim of this study was to investigate our experience with hip fractures in this group and to record the cost of treating these fractures to identify both the social and economic impact these injuries impose on the health system...
March 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28242236/centenarians-as-extreme-phenotypes-an-ecological-perspective-to-get-insight-into-the-relationship-between-the-genetics-of-longevity-and-age-associated-diseases
#14
REVIEW
Cristina Giuliani, Chiara Pirazzini, Massimo Delledonne, Luciano Xumerle, Patrick Descombes, Julien Marquis, Giacomo Mengozzi, Daniela Monti, Dina Bellizzi, Giuseppe Passarino, Donata Luiselli, Claudio Franceschi, Paolo Garagnani
In this review we address the genetic continuum between aging and age-related diseases, with particular attention to the ecological perspective. We describe the connections between genes that promote longevity and genes associated to age-related diseases considering trade-off mechanisms in which the same genetic variants could have different effect according to the tissue considered and could be involved in several biological pathways. Then we describe mechanisms of antagonistic pleiotropy, focusing on the complex interplay between genetic variants and environmental changes (internal or external)...
February 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28230198/longitudinal-association-of-hypertension-and-diabetes-mellitus-with-cognitive-functioning-in-a-general-70-year-old-population-the-sonic-study
#15
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ryosuke Oguro, Chikako Nakama, Serina Yokoyama, Motonori Nagasawa, Satomi Maeda-Hirao, Yuki Imaizumi, Miyuki Takeya, Hiroko Yamamoto, Masao Takeda, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Saori Yasumoto, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yasumichi Arai, Tatsuro Ishizaki, Ryutaro Takahashi, Hiromi Rakugi
Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years...
February 23, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28214534/demographic-phenotypic-and-genetic-characteristics-of-centenarians-in-okinawa-and-honshu-japan-part-2-honshu-japan
#16
REVIEW
Yasumichi Arai, Takashi Sasaki, Nobuyoshi Hirose
The scope and purpose of this review was to summarize the aims, methods, findings, and future of centenarian and (semi)-supercentenarian studies in Japan, particularly those from our own interdisciplinary laboratory. Medically, approximately 97% of centenarians contract chronic diseases including hypertension and gastrointestinal disease; however, they present with few cardiovascular risk factors. The low prevalence of diabetes mellitus and carotid atherosclerotic plaques is peculiarities of centenarians, which could be associated with high adiponectin levels...
February 16, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28164210/chronic-conditions-and-use-of-health-care-service-among-german-centenarians
#17
Petra von Berenberg, Dagmar Dräger, Thomas Zahn, Julia Neuwirth, Adelheid Kuhlmey, Paul Gellert
No abstract text is available yet for this article.
February 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28144787/-centenarians-preparing-for-the-end-of-life
#18
Simon Eggert, Adelheid Kuhlmey, Ralf Suhr, Dagmar Dräger
BACKGROUND: The population of centenarians has grown immensely in Germany but has yet hardly been considered in research on dying and death. Due to their very old age centenarians are especially intensively confronted with the challenge of the end of life. OBJECTIVE: The aim of this study was to analyze how centenarians handle the existential challenge of the end of life and which aspects are especially significant for them. Conclusions drawn from this analysis were used to identify factors to improve the needs-based provision of care...
January 31, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28049008/the-gut-microbiota-of-centenarians-signatures-of-longevity-in-the-gut-microbiota-profile
#19
REVIEW
Biagi Elena, Simone Rampelli, Silvia Turroni, Sara Quercia, Marco Candela, Patrizia Brigidi
The changing physiology and lifestyle of elderly people affect the gut microbiota composition, the changes of which can, in turn, affect the health maintenance of the ageing host. In a co-evolutionary vision of the relationship between gut microbiota and ageing as an adaptive process of the human superorganism, long-living individuals who get to "successfully" age might be the ones whose microbiota manages to continuously re-establish a mutualistic relationship with the host, adapting to the progressive endogenous and environmental changes...
December 31, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28040447/demographics-phenotypic-health-characteristics-and-genetic-analysis-of-centenarians-in-china
#20
REVIEW
Yi Zeng, Qiushi Feng, Danan Gu, James W Vaupel
After a brief introduction to the background, significance and unique features of the centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity Study (CLHLS), which is the world's largest study of centenarians, nonagenarians, octogenarians, and compatible young-old aged 65-79. Based on the CLHLS data and other relevant studies, we summarize demographic and socioeconomic characteristics as well as self-reported and objectively-tested health indicators of centenarians in China, with an emphasis on gender differences and rural/urban disparities...
December 28, 2016: Mechanisms of Ageing and Development
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