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Taiji Ogawa, Masahiro Uota, Kazunori Ikebe, Yasumichi Arai, Kei Kamide, Yasuyuki Gondo, Yukie Masui, Tatsuro Ishizaki, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Kodai Hatta, Yoshinobu Maeda
The sense of taste plays a pivotal role for personal assessment of the nutritional value, safety, and quality of foods. Although it is commonly recognized that taste sensitivity decreases with age, alterations in that sensitivity over time in an old-old population have not been previously reported. Furthermore, no known studies utilized comprehensive variables regarding taste changes and related factors for assessments. Here, we report novel findings from a 3-year longitudinal study model aimed to elucidate taste sensitivity decline and its related factors in old-old individuals...
October 17, 2016: Journal of Oral Rehabilitation
Stefania Nicola, Angela Amoruso, Francesca Deidda, Marco Pane, Serena Allesina, Luca Mogna, Mario Del Piano, Giovanni Mogna
GOALS: To investigate the modulation of human cytokines by Bifidobacterium longum strains isolated from Centenarians. In particular, we measured the production of interleukin (IL)-12p70, interferon-γ, IL-17A, and IL-4 from human peripheral blood mononuclear cells after stimulation with live bacteria. BACKGROUND: Probiotics may inhibit pathogens and modulate the immune system, bringing a beneficial effect on human health. Among the probiotic strains, bifidobacteria play a key role in the maturation of the host's immune system...
November 2016: Journal of Clinical Gastroenterology
Nimmi Hutnik, Pam Smith, Tina Koch
AIM: In 2010, we interviewed 16 UK centenarians about their lives and later published a paper on the socio-emotional aspects of positive ageing. We were struck by their ability to 'move on' from difficult situations which we recognized conceptually as 'resilience'. In the effort to understand aspects of resilience as portrayed in their stories, we re-examined their data. METHODOLOGY: In the original study, we used participatory action research (PAR) for its storytelling and group process components...
April 2016: Nurs Open
A P da Silva, A Matos, R Ribeiro, Â Gil, A Valente, M Bicho, J Gorjão-Clara
BACKGROUND/OBJECTIVES: To evaluate the prevalence of sarcopenia and osteoporosis in centenarians and its association with body composition and past physical activity (PPA). SUBJECTS/METHODS: We conducted an observational cross-sectional study in a representative nationwide population of 253 Portuguese centenarians. A clinically oriented questionnaire and anthropometric and body composition analysis by bioimpedance were executed. Sarcopenia was determined using a muscle mass (MM) index cutoff ⩽16...
September 21, 2016: European Journal of Clinical Nutrition
Christine J Huh, Bo Zhang, Matheus B Victor, Sonika Dahiya, Luis Fz Batista, Steve Horvath, Andrew S Yoo
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neurons that maintain multiple age-associated signatures...
September 20, 2016: ELife
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ken Sugimoto, Takeshi Nakagawa, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi
OBJECTIVE: It is well-documented that midlife hypertension (HT) is associated with decline of cognitive function. Recently, we reported that the influence of HT and/or elevated blood pressure on the progression of cognitive decline was attenuated at late life aged 70 of the general population in cross-sectional analysis. The purpose of this study is to investigate the 3 years' longitudinal effect of HT and additive risk factors on decline of cognitive function for 70-year-old general Japanese population in the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, which is a narrow age range cohort...
September 2016: Journal of Hypertension
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu, Wang-Wei Cai
OBJECTIVE: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. METHODS: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). RESULTS: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0...
September 2016: Asian Pacific Journal of Tropical Medicine
Noriyuki Fuku, Roberto Díaz-Peña, Yasumichi Arai, Yukiko Abe, Helios Pareja-Galeano, Fabián Sanchis-Gomar, Alejandro Santos-Lozano, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Letizia Venturini, Giovanni Ricevuti, Hirose Nobuyoshi, Enzo Emanuele, Alejandro Lucia
OBJECTIVES: Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. STUDY DESIGN AND MAIN OUTCOME MEASURES: Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls)...
October 2016: Maturitas
Yong-Han He, Xiao-Qiong Chen, Dong-Jing Yan, Fu-Hui Xiao, Rong Lin, Xiao-Ping Liao, Yao-Wen Liu, Shao-Yan Pu, Qin Yu, Hong-Peng Sun, Jian-Jun Jiang, Wang-Wei Cai, Qing-Peng Kong
Reduced mitochondrial function is an important cause of aging and age-related diseases. We previously revealed a relatively higher level of mitochondrial DNA (mtDNA) content in centenarians. However, it is still unknown whether such an mtDNA content pattern of centenarians could be passed on to their offspring and how it was regulated. To address these issues, we recruited 60 longevity families consisting of 206 family members (cohort 1) and explored their mtDNA copy number. The results showed that the first generation of the offspring (F1 offspring) had a higher level of mtDNA copy number than their spouses (p < 0...
August 6, 2016: Neurobiology of Aging
Masaki Takao, Nobuyoshi Hirose, Yasumichi Arai, Ban Mihara, Masaru Mimura
Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders...
2016: Acta Neuropathologica Communications
Yoshiko Lily Ishioka, Yasuyuki Gondo, Noriyuki Fuku, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yukiko Abe, Yasumichi Arai, Nobuyoshi Hirose
Apolipoprotein E (APOE) ε4 allele and education have been reported to affect the cognitive function in young-old adults. However, the effects and interactions of the ε4 allele and education on cognitive function in very old age, particularly in centenarians, are not well known. We studied 542 Japanese centenarians. Using the data in total of 452 participants (74 men and 378 women, mean age 103.6 ± 3.2 years) who were genotyped and assessed cognitive function with the Mini-Mental States Examination (MMSE), we examined the effects and interactions of the ε4 allele and education on the MMSE score...
August 24, 2016: Age (2005-)
Rita Ostan, Daniela Monti, Paola Gueresi, Mauro Bussolotto, Claudio Franceschi, Giovannella Baggio
Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and demographic data and stressing the importance of a comprehensive historical perspective and a gene-environment/lifestyle interaction. Gender difference regarding prevalence and incidence of the most important age-related diseases, such as cardiovascular and neurodegenerative diseases, cancer, Type 2 diabetes, disability, autoimmunity and infections, are reviewed and updated with particular attention to the role of the immune system and immunosenescence...
October 1, 2016: Clinical Science (1979-)
Lia Araújo, Oscar Ribeiro, Constança Paúl
The purpose of this study was to explore the role of existential beliefs in mediating the influence of health on centenarians' well-being. A total of 80 centenarians (mean age 101.1; SD = 1.3; 81.3 % women) with no/minor cognitive impairment were included. The OARS questionnaire for diseases and functional capacity (ADL, IADL), the Satisfaction with Life Scale, and the existential beliefs subscale were used for data collection. The findings suggest that existential resources are a crucial element for mitigating the impact of health constraints in subjective well-being in this population...
August 23, 2016: Journal of Religion and Health
Peter S Pressman, Yuliana Noniyeva, Nick Bott, Shubir Dutt, Virginia Sturm, Bruce L Miller, Joel H Kramer
Many emotional functions are relatively preserved in aging despite declines in several cognitive domains and physical health. High levels of happiness exist even among centenarians. To address the hypothesis of whether preservation of emotional function in healthy aging may relate to different rates of age-related volume loss across brain structures, we performed two volumetric analyses on structural magnetic resonance neuroimaging of a group of healthy aging research participants using Freesurfer version 5...
2016: PloS One
Li Wang, Yonghua Li, Hairong Li, Jennifer Holdaway, Zhe Hao, Wuyi Wang, Thomas Krafft
The factors that influence the length of human life are complex and longevity remains a controversial topic, particularly in China. This paper demonstrates the spatial patterns and changes of the elderly group (65 years old and over), the oldest old (80 years old and over) and the centenarians in China in the last decade, analyzes the influence of economic development on aging, and in the end, using a case study, explores the characteristics of the centenarians' behavior. The results indicate that high elderly and the oldest old proportions are more common in regions with higher socio-economic development and that have a favorable climate...
November 2016: Archives of Gerontology and Geriatrics
Peggy A Lockhart, Peter Martin, Mary Ann Johnson, Elizabeth Shirtcliff, Leonard W Poon
Longevity in women has been found to be associated with several reproductive factors; the age of women when they give birth, their total number of children, and the age at which they experience menopause. In the context of expectations from the evolutionary theory of aging, the focus of this study examined relationships between lifetime reproduction, age at menopause and longevity, while accounting for various lifestyle factors. The purpose of this study was to assess fertility and age at onset of menopause in 197 women of the Georgia Centenarian Study...
August 12, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
A Pereira Da Silva, N Ramos Marques, A Matos, A Gil, J Gorjão Clara, M Bicho
OBJECTIVE: To assess, in a sample of Portuguese Centenarians compared with a control sample of lower age individuals, the blood pressure levels, the distribution of genotypes associated with the renin-angiotensin-aldosterone axis and its association with hypertension. DESIGN AND METHOD: The study comprised 253 centenarians, with a mean age of 100.3 ± 2.0 years old, from different regions of Portugal. The control group included 268 individuals with mean age of 67...
September 2016: Journal of Hypertension
A Pereira Da Silva, A Matos, R Ribeiro, A Gil, J Gorjão Clara, M Pires Bicho
OBJECTIVE: To assess blood pressure (BP) levels and the prevalence of hypertension (HBP) and its control in individuals centenarians in Portugal. DESIGN AND METHOD: The study comprised a Caucasian population of 253 centenarians (77.9% women), with a mean age of 100.3 ± 2.0 years old, from different regions of Portugal. It were hypertension criteria those of ESH/ESC 2013 and or under anti hypertensive medication. Controlled BP values were considered according to JNC8...
September 2016: Journal of Hypertension
Paula K Friedman, Ira B Lamster
Many factors contribute to human tooth loss, including oral hygiene practices, trauma, smoking, health status, socio-economic status and individual preferences. Loss of teeth impairs quality-of-life measures, including the eating of most foods that require full masticatory function. A recent study of centenarians found that at age 65-74 years, those who lived to be 100 had a lower rate of edentulism than did younger members of their birth cohort at ages 65-74 years. Oral health was consistent with compression of morbidity toward the end of life...
October 2016: Periodontology 2000
Romuald Lepers, Paul J Stapley, Thomas Cattagni
BACKGROUND: some centenarians are engaged in regular physical activity and sometimes in sporting events. OBJECTIVE: we aimed to identify world records of centenarian athletes in several sports and determine which represented the best performance when compared to all-age world records, all disciplines taken together. METHODS: all of the best performances achieved by centenarians were identified and compared in three disciplines: athletics, swimming and cycling...
September 2016: Age and Ageing
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