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'Case in point'

Schirin Akhbari Ziegler, Tineke Dirks, Mijna Hadders-Algra
BACKGROUND: Coaching is en vogue in pediatric physiotherapy, but often applied rather unspecific and undefined. METHODS: This paper aims to describe coaching in early physiotherapy intervention, taking the specific coaching approach of the family-centered program "COPing with and CAring for infants with special needs" (COPCA) as a case in point. RESULTS: The theoretical underpinnings of coaching in COPCA, including a meta-model, family-centered practice, the Neuronal Group Selection Theory and the goal-oriented coaching approach, are discussed...
March 16, 2018: Disability and Rehabilitation
Camila Soares Moreira de Sousa, Bárbara Bezerra de Castro, Carla Lorena Vasques Mendes de Miranda, Breno Braga Bastos, Marcelo Coelho Avelino
No abstract text is available yet for this article.
January 2018: Radiologia Brasileira
Szilvia Geyh, Urban Schwegler, Claudio Peter, Rachel Müller
PURPOSE: To discuss the representation and organization of information describing persons' lived experience of health from a personal factors perspective in the light of the International Classification of Functioning, Disability and Health, using spinal cord injury as a case in point for disability. METHODS: The scientific literature was reviewed, discussion rounds conducted, and qualitative secondary analyses of data carried out using an iterative inductive-deductive approach...
March 6, 2018: Disability and Rehabilitation
Kathleen Abu-Saad, Shlomit Avni, Ofra Kalter-Leibovici
BACKGROUND: Health disparities are a persistent problem in many high-income countries. Health policymakers recognize the need to develop systematic methods for documenting and tracking these disparities in order to reduce them. The experience of the U.S., which has a well-established health disparities monitoring infrastructure, provides useful insights for other countries. MAIN BODY: This article provides an in-depth review of health disparities monitoring in the U...
February 28, 2018: Israel Journal of Health Policy Research
Divya Narain, Martine Maron
Biodiversity offsetting aims to compensate for development-induced biodiversity loss through commensurate conservation gains and is gaining traction among governments and businesses. However, cost shifting (i.e., diversion of offset funds to other conservation programs) and other perverse incentives can undermine the effectiveness of biodiversity offsetting. Additionality - the requirement that biodiversity offsets result in conservation outcomes that would not have been achieved otherwise - is fundamental to biodiversity offsetting...
February 23, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
Ece Nur Degirmentepe, Sule Gungor, Emek Kocaturk, Utkan Kiziltac, Mine Adas, Selver Ozekinci, Amor Khachemoune
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered...
August 15, 2017: Dermatology Online Journal
Vasant S Shinde, Yong Jun Kim, Eun Jin Woo, Nilesh Jadhav, Pranjali Waghmare, Yogesh Yadav, Avradeep Munshi, Malavika Chatterjee, Amrithavalli Panyam, Jong Ha Hong, Chang Seok Oh, Dong Hoon Shin
An insufficient number of archaeological surveys has been carried out to date on Harappan Civilization cemeteries. One case in point is the necropolis at Rakhigarhi site (Haryana, India), one of the largest cities of the Harappan Civilization, where most burials within the cemetery remained uninvestigated. Over the course of the past three seasons (2013 to 2016), we therefore conducted excavations in an attempt to remedy this data shortfall. In brief, we found different kinds of graves co-existing within the Rakhigarhi cemetery in varying proportions...
2018: PloS One
Mengni Chen, Chris J Lloyd, Paul S F Yip
A country's total fertility rate (TFR) depends on many factors. Attributing changes in TFR to changes of policy is difficult, as they could easily be correlated with changes in the unmeasured drivers of TFR. A case in point is Australia where both pronatalist effort and TFR increased in lock step from 2001 to 2008 and then decreased. The global financial crisis or other unobserved confounders might explain both the reducing TFR and pronatalist incentives after 2008. Therefore, it is difficult to estimate causal effects of policy using econometric techniques...
2018: PloS One
Gavin J Andrews
Human geography's varied engagement with the brain has involved considerations of the way people know and respond to their environments, and their place-based experiences with emotions, mental illnesses and disorders, intellectual disabilities and particular neurological conditions. This paper argues however that this scholarship could be augmented by, and existing expertise be directed towards, considering physical brain abnormalities and injuries. As a case in point it considers the spatial experience of living with Type 1 Chiari Malformation...
January 27, 2018: Social Science & Medicine
Ye Wang, Xueli Wu, Liu Du, Ju Zheng, Songqing Deng, Xin Bi, Qiuyan Chen, Hongning Xie, Claude Férec, David N Cooper, Yanmin Luo, Qun Fang, Jian-Min Chen
BACKGROUND: Whole-exome sequencing (WES) over the last few years has been increasingly employed for clinical diagnosis. However, one caveat with its use is that it inevitably fails to detect disease-causative variants that occur within noncoding RNA genes. Our experience in identifying pathogenic variants in the noncoding RNU4ATAC gene, in a Chinese family where two successive foetuses had been affected by severe microcephaly, is a case in point. These foetuses exhibited remarkably similar phenotypes in terms of their microcephaly and brain abnormalities; however, the paucity of other characteristic phenotypic features had made a precise diagnosis impossible...
January 25, 2018: Human Genomics
Allan McDougall, Elizabeth Anne Kinsella, Mark Goldszmidt, Karen Harkness, Patricia Strachan, Lorelei Lingard
For patients living with chronic illnesses, self-care has been linked with positive outcomes such as decreased hospitalisation, longer lifespan, and improved quality of life. However, despite calls for more and better self-care interventions, behaviour change trials have repeatedly fallen short on demonstrating effectiveness. The literature on heart failure (HF) stands as a case in point, and a growing body of HF studies advocate realist approaches to self-care research and policymaking. We label this trend the 'realist turn' in HF self-care...
January 2018: Sociology of Health & Illness
Xiaocong Chen, Yanping Dong, Xiufen Yu
The predictive validity of various corpus-based frequency norms in first-language lexical processing has been intensively investigated in previous research, but less attention has been paid to this issue in second-language (L2) processing. To bridge the gap, in the present study we took English as a case in point and compared the predictive power of a large set of corpus-based frequency norms for the performance of an L2 English visual lexical decision task (LDT). Our results showed that, in general, the frequency norms from SUBTLEX-US and WorldLex-Blog tended to predict L2 performance better in reaction times, whereas the frequency norms from corpora with a mixture of written and spoken genres (CELEX, WorldLex-Blog, BNC, ANC, and COCA) tended to predict L2 accuracy better...
January 16, 2018: Behavior Research Methods
Udo Schuklenk
No abstract text is available yet for this article.
February 2018: Bioethics
Maria Grazia Masiello, Roberto Verna, Alessandra Cucina, Mariano Bizzarri
Data obtained by studying mammalian cells in absence of gravity strongly support the notion that cell fate specification cannot be understood according to the current molecular model. A paradigmatic case in point is provided by studying cell populations growing in absence of gravity. When the physical constraint (gravity) is 'experimentally removed', cells spontaneously allocate into two morphologically different phenotypes. Such phenomenon is likely enacted by the intrinsic stochasticity, which, in turn, is successively 'canalized' by a specific gene regulatory network...
January 4, 2018: Progress in Biophysics and Molecular Biology
Chenling Xu Antelope, Davide Marnetto, Fergal Casey, Emilia Huerta-Sanchez
Access to a geographically diverse set of modern human samples from the present time and from ancient remains, combined with archaic hominin samples, provides an unprecedented level of resolution to study both human history and adaptation. The amount and quality of ancient human data continue to improve and enable tracking the trajectory of genetic variation over time. These data have the potential to help us redefine or generate new hypotheses of how human evolution occurred and to revise previous conjectures...
January 2017: Human Biology
Konstantinos Pateras, Stavros Nikolakopoulos, Kit Roes
Simulation studies to evaluate performance of statistical methods require a well-specified data-generating model. Details of these models are essential to interpret the results and arrive at proper conclusions. A case in point is random-effects meta-analysis of dichotomous outcomes. We reviewed a number of simulation studies that evaluated approximate normal models for meta-analysis of dichotomous outcomes, and we assessed the data-generating models that were used to generate events for a series of (heterogeneous) trials...
March 30, 2018: Statistics in Medicine
Diana Wider, Didier Picard
The availability of a wide range of reporter proteins, which can easily be quantitated, has had a major impact on many fields of biomedical research. In some experiments with tissue culture cells, it is necessary to control for differences in transfection efficiency and in other expression parameters. This requirement has been very conveniently met with the popular dual luciferase assay. Its disadvantages are the requirement for cell lysis, the inability to analyze the same cells repeatedly, and the cost, at least in its most commonly used commercial format...
2017: PloS One
Jarod L Roland, Abraham Z Snyder, Carl D Hacker, Anish Mitra, Joshua S Shimony, David D Limbrick, Marcus E Raichle, Matthew D Smyth, Eric C Leuthardt
Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal) connectivity. However, this relation is not one-to-one. Interhemispheric functional connectivity in relation to the corpus callosum presents a case in point. Specifically, several reports have documented nearly intact interhemispheric functional connectivity in individuals in whom the corpus callosum (the major commissure between the hemispheres) never develops...
December 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
Mihaela Nedelcu
Taking transnational families of Romanian migrants in Canada and Switzerland as a case in point, this paper accounts for the emergence of new patterns of "grandparenting" and "doing family" practices in the digital age, based on ICTs-mediated co-presence. It shows that migrants' parents are able to acquire manifold technological skills in order to cope with distance and separation and to improve the quality of their interaction and relationships with children and grandchildren living abroad...
December 2017: European Journal of Ageing
Francesco Chiappelli, Allen Khakshooy, Nicole Balenton
Cholera remains a feared, aggressive, infectious and lethal disease today, despite several decades of intense research, concerted public health modalities designed to prevent, and to control outbreaks, availability of efficacious vaccines aimed at containing its contagious spread, and effective patient-centered medical interventions for reducing morbidity and mortality. Despite these advances, cholera still strikes communities around the world, especially in countries and regions of the globe where medical and nursing care cannot be as effectively proffered to the population at risk as in First World economies...
2017: Bioinformation
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