keyword
MENU ▼
Read by QxMD icon Read
search

hepatitis B virus infection in pregnancy

keyword
https://www.readbyqxmd.com/read/29227001/antiviral-therapy-for-hepatitis-b-virus-during-second-pregnancies
#1
Yasuhiro Wakano, Tokio Sugiura, Takeshi Endo, Koichi Ito, Mitsuyoshi Suzuki, Hitoshi Tajiri, Yasuhito Tanaka, Shinji Saitoh
Mother-to-child transmission of the hepatitis B virus (HBV) is a major concern for infected mothers, especially after their first child has become an HBV carrier despite immunoprophylaxis. Eight mothers whose first child had become an HBV carrier despite immunoprophylaxis were referred for antiviral therapy during the subsequent pregnancy. All pregnant women were seropositive for both the hepatitis B surface antigen and hepatitis B e antigen. In the treatment group (three receiving lamivudine and two receiving tenofovir), mother-to-child transmission of the HBV was successfully prevented in all infants (5/5)...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29225131/role-of-tenofovir-alafenamide-taf-in-the-treatment-and-prophylaxis-of-hiv-and-hbv-infections
#2
REVIEW
Erik De Clercq
Tenofovir (TFV) is the cornerstone in the treatment and prophylaxis of HIV infections. It has been routinely used in its prodrug form TDF (tenofovir disoproxil fumarate) combined with emtricitabine ((-)FTC) and other antiretroviral agents. TDF has now been replaced by TAF (tenofovir alafenamide) which allows better uptake by the lymphoid tissue. In combination with elvitegravir (E), cobicistat (C), emtricitabine (F), TAF can be advocated as an STR (single tablet regimen, Genvoya®) for the treatment of HIV infections...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29193547/safety-and-efficacy-of-telbivudine-in-late-pregnancy-to-prevent-mother-to-child-transmission-of-hepatitis-b-virus-a-multicenter-prospective-cohort-study
#3
Yali Hu, Chenyu Xu, Biao Xu, Lingqing Hu, Qin Liu, Jie Chen, Jingli Liu, Lanhua Liu, Jishi Yang, Tingmei Chen, Jian Wen, Na Jiang, Yaguang Zhang, Minkai Cao, Jing Feng, Xiaoqian Lin, Zhiqun Wang, Biyun Xu, Yi-Hua Zhou
Infection of hepatitis B virus (HBV) occurs in ~10% of infants of HBV-infected mothers with positive hepatitis B e antigen (HBeAg) after immunoprophylaxis. We aimed to evaluate the safety and efficacy of telbivudine used during late pregnancy for preventing mother-to-child transmission of HBV. We conducted a multicenter prospective cohort study in five hospitals from 2012-2014, which enrolled HBV-infected singleton pregnant women with positive HBeAg. By their choice, women were divided into therapy (telbivudine 600 mg/day, from gestation 28-32 weeks to 3-4 weeks postpartum) and control (no antiviral agent) groups...
November 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29185251/ultrasound-indications-for-maternal-storch-testing-in-pregnancy
#4
Cora Alexandra Voekt, Therese Rinderknecht, Hans Hellmuth Hirsch, Annette Blaich, Irene Mathilde Hösli
AIMS OF THE STUDY: Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of serologies to detect possible maternal STORCH infections encompassing syphilis, Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, and others (human immunodeficiency virus, hepatitis B and C, parvovirus B19, enterovirus, varicella zoster, and Leptospira interrogans). The value of indiscriminate testing for infections upon the detection of fetal ultrasound abnormalities has been questioned...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29181424/comparative-effectiveness-of-prophylactic-strategies-for-perinatal-transmission-of-hepatitis-b-virus-a-network-meta-analysis-of-randomized-controlled-trials
#5
Zhi-Xian Chen, Xun Zhuang, Xiao-Hong Zhu, Yan-Li Hao, Gui-Fang Gu, Meng-Zhi Cai, Gang Qin
Background: Perinatal transmission is the main route of hepatitis B virus (HBV) transmission. While several measures have been attempted as means of preventing perinatal HBV transmission, the optimal strategy remains inconclusive. Methods: We conducted a comprehensive search, through December 2016, for randomized controlled trials (RCTs) that compared the following measures among pregnant women with HBV infection: placebo/none, active immunoprophylaxis (hepatitis B vaccine series starting at birth [HBVac]), passive-active immunoprophylaxis (hepatitis B immunoglobulin and vaccine [HBIG+HBVac]), prenatal HBIG administration (HBIG/HBIG+HBVac), and prenatal antiviral therapy (AVT/HBIG+HBVac)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29111540/transcription-and-regulation-of-hepatitis-b-virus-genes-in-host-sperm-cells
#6
Ying Zhong, Dong-Ling Liu, Mohamed Morsi M Ahmed, Peng-Hao Li, Xiao-Ling Zhou, Qing-Dong Xie, Xiao-Qing Xu, Ting-Ting Han, Zhi-Wei Hou, Ji-Hua Huang, Lan Xu, Tian-Hua Huang
To investigate whether transcription of hepatitis B virus (HBV) gene occurs in human sperm, total RNA was extracted from sperm of patients with chronic HBV infection (test-1), from donor sperm transfected with a plasmid containing the full-length HBV genome (test-2), and from nontransfected donor sperm (control), used as the template for reverse transcription-polymerase chain reaction (RT-PCR). Positive bands for HBV DNA were observed in the test groups but not in the control. Next, to identify the role of host genes in regulating viral gene transcription in sperm, total RNA was extracted from 2-cell embryos derived from hamster oocytes fertilized in vitro by HBV-transfected (test) or nontransfected (control) human sperm and successively subjected to SMART-PCR, suppression subtractive hybridization, T/A cloning, bacterial amplification, microarray hybridization, sequencing and the Basic Local Alignment Search Tool (BLAST) search to isolate differentially expressed genes...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29082653/telbivudine-therapy-for-gravidas-with-chronic-hepatitis-b-infection-and-patients-at-risk-of-renal-impairment
#7
REVIEW
J Liu, T Chen, Y Zhao
Hepatitis B virus infection is currently the most important cause of chronic viral hepatitis worldwide and is one of the most frequent causes of end-stage liver disease. With the international implementation of the hepatitis B vaccine and combined prophylaxis for infants born to HBsAg(+) mothers, the prevalence of hepatitis B has decreased remarkably. However, intra-uterine transmission has become a critical bottleneck for eliminating hepatitis B infection. The efficacy of nucleos(t)ide analogs on inhibiting hepatitis B replication has been widely confirmed, and the quality of life and the survival of individuals with chronic hepatitis B (CHB) have improved to a great degree...
November 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29082646/safety-and-efficacy-of-telbivudine-for-chronic-hepatitis-b-during-the-entire-pregnancy-long-term-follow-up
#8
J Shang, Q Wen, C C Wang, K Liu, L Bai, H Tang
The management of hepatitis B virus (HBV) infection in pregnancy is a unique issue. Telbivudine (LdT) is recommended to block HBV mother-to-child transmission (MTCT) in the third trimester. However, the safety of LdT treatment during the entire pregnancy for the long-term growth of infants is unclear. The aim of this study was to evaluate the efficacy and long-term safety of LdT for the entire pregnancy period. This retrospective cohort study included 40 pregnant women and 43 children from 2011 to 2017. The antiviral effects and maternal abnormalities were evaluated...
November 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29027107/viral-factors-for-hbv-mother-to-child-transmission
#9
James S Park, Calvin Q Pan
Chronic hepatitis B virus (HBV) remains a leading cause of cirrhosis and hepatocellular carcinoma worldwide. Because chronic hepatitis B infection is rarely eradicated, preventing mother-to-child transmission (MTCT) is the most effective strategy to eliminate HBV globally. Although immunoprophylaxis strategy is widely available and effective for infants born to mothers with chronic hepatitis B infection, postnatal immunoprophylaxis fails in approximately 5-10 % of infants, and this failure rate goes up to 30 % in infants born to highly viremic mothers...
October 12, 2017: Hepatology International
https://www.readbyqxmd.com/read/28945149/risk-of-developing-antiphospholipid-antibodies-following-viral-infection-a-systematic-review-and-meta-analysis
#10
N Abdel-Wahab, S Talathi, M A Lopez-Olivo, M E Suarez-Almazor
Objective The objective of this paper is to conduct a systematic review and meta-analysis on the risk of developing elevated antiphospholipid (aPL) antibodies and related thromboembolic and/or pregnancy events following a viral infection. Method We searched Medline, EMBASE, Web of Science, PubMed ePubs, and Cochrane Central Register of Controlled Trials through June 2016. Independent observational studies of elevated aPL antibodies in patients with a viral infection compared with controls or patients with lupus were included...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28941137/incidence-determinants-and-outcomes-of-pregnancy-associated-hepatitis-b-flares-a-regional-hospital-based-cohort%C3%A2-study
#11
Tatyana Kushner, Pamela A Shaw, Ankush Kalra, Lora Magaldi, Pooja Monpara, Gurneet Bedi, Karen Krok, Sierra Centkowski, Katherine Dalldorf, Julia D'souza, Dina Halegoua-De Marzio, David S Goldberg, Stacey Trooskin, Lisa D Levine, Sindhu K Srinivas, James D Lewis, Kimberly A Forde, Vincent Lo Re
BACKGROUND & AIMS: There is limited knowledge about hepatitis B virus (HBV) flare among pregnant women. We evaluated the incidence, determinants and outcomes of HBV flare in a multicultural cohort of pregnant HBV-infected women in the United States. METHODS: We performed a retrospective cohort study of pregnant hepatitis B surface antigen-positive women cared for at hospital-based clinics of 4 medical centres in Southeastern Pennsylvania from 2006 to 2015. The main outcome was incident HBV flare (alanine aminotransferase [ALT] ≥2 times upper limit of normal) during pregnancy or within 6 months after delivery...
September 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28935971/prevalence-of-chronic-hepatitis-b-and-status-of-hbv-care-among-rural-women-who-planned-to-conceive-in-china
#12
Yuanyuan Wang, Hong Zhou, Long Zhang, Qiuyue Zhong, Qiaomei Wang, Haiping Shen, Man Zhang, Yanjie Huang, Anqi Wang, Kenrad Nelson, Yiping Zhang, Donghai Yan, Zuoqi Peng, Ya Zhang, Xiaona Xin, Hongguang Zhang, Jun Zhao, Yan Wang, Ying Yang, Yuan He, Jihong Xu, Xiaoli Liu, Yan Wang, Xu Ma
Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935430/-health-care-needs-and-barriers-in-seeking-medical-care-for-global-health-and-sexual-and-reproductive-health-among-students-from-f%C3%A3-lix-houphou%C3%A3-t-boigny-university-abidjan-c%C3%A3-te-d-ivoire
#13
M Inghels, P A Coffie, J Larmarange
BACKGROUND: In Ivory Coast, little is known about health needs and health access barriers among young people. The aim of this study was to describe health provision, health needs and barriers when seeking medical care, with an emphasis on sexual and reproductive health, and the acceptability of a medical examination for students attending their first year at the Houphouët-Boigny University, Abidjan, Ivory Coast. METHODS: We conducted a representative cross-sectional study among second year students who were selected by two-stage equiprobable random sampling...
September 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28913146/fetomaternal-outcomes-in-pregnant-women-with-hepatitis-e-infection-still-an-important-fetomaternal-killer-with-an-unresolved-mystery-of-increased-virulence-in-pregnancy
#14
Namrata Kumar, Vinita Das, Anjoo Agarwal, Amita Pandey, Smriti Agrawal
OBJECTIVE: Hepatitis is a prevalent infection in developing countries. While hepatitis B and C are deepening their roots in the developed world, hepatitis A and E are common in the developing world. The uniqueness of hepatitis is in its transformation from a relatively self-limiting disease in the non-pregnant state, to a highly virulent disease during pregnancy. MATERIALS AND METHODS: This retrospective observational study was conducted in the Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, for a period of six months from June 2016 to November 2016 [probably during an endemic peak of hepatitis E virus (HEV)] to observe the clinical outcomes in HEV-infected pregnant women...
June 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28893207/hepatitis-b-virus-and-hiv-co-infection-among-pregnant-women-in-rwanda
#15
Mwumvaneza Mutagoma, Helene Balisanga, Samuel S Malamba, Dieudonné Sebuhoro, Eric Remera, David J Riedel, Steve Kanters, Sabin Nsanzimana
BACKGROUND: Hepatitis B virus (HBV) affects people worldwide but the local burden especially in pregnant women and their new born babies is unknown. In Rwanda HIV-infected individuals who are also infected with HBV are supposed to be initiated on ART immediately. HBV is easily transmitted from mother to child during delivery. We sought to estimate the prevalence of chronic HBV infection among pregnant women attending ante-natal clinic (ANC) in Rwanda and to determine factors associated with HBV and HIV co-infection...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28876308/the-need-to-promote-sexual-health-in-america-a-new-vision-for-public-health-action
#16
Jessie V Ford, Megan B Ivankovich, John M Douglas, Edward W Hook, Lynn Barclay, Joycelyn Elders, David Satcher, Eli Coleman
Sexual health is considered to be a state of wellness with physical, emotional, mental, and social dimensions. Sexual health can contribute to our overall well-being in each of these dimensions. However, despite the intrinsic importance and positive aspects of sexuality in our lives, the United States presently faces significant challenges related to the sexual health of its citizens, including human immunodeficiency virus, other sexually transmitted infections, viral hepatitis, unintended pregnancies, sexual violence, sexual dysfunction, and cancers in reproductive tracts with serious disparities among the populations affected...
June 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28834623/hepatitis-b-virus-hepatitis-d-virus-mother-to-child-co-transmission-a-retrospective-study-in-a-developed-country
#17
Pierre Sellier, Sarah Maylin, Ségolène Brichler, Béatrice Berçot, Amanda Lopes, Dorothée Chopin, Manuela Pogliaghi, Anne-Lise Munier, Véronique Delcey, Guy Simoneau, John Evans, Emmanuel Gordien, François Simon, Jean-François Bergmann
BACKGROUND & AIMS: Hepatitis B Virus (HBV) DNA during chronic infection can reach levels at which mother-to-child (MTC) transmission frequently occurs despite passive-active immunization of newborns. Hepatitis D Virus (HDV) RNA can reach high levels, we assessed HBV/HDV MTC co-transmission. METHODS: Monocentric retrospective study (registered in ClinicalTrials. gov (NCT02044055)), after informed consent in HBV/HDV co-infected women pregnant between 01/01/2004 and 01/01/2015 in Paris, France...
August 23, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28830531/seroprevalence-of-hepatitis-b-virus-surface-antigen-and-factors-associated-among-pregnant-women-in-dawuro-zone-snnpr-southwest-ethiopia-a-cross-sectional-study
#18
Asrat Chernet, Aman Yesuf, Amsalu Alagaw
BACKGROUND: Hepatitis B is the world's most common serious liver infection. Infection by hepatitis B virus during pregnancy has high rate of vertical transmission and adverse effect on both the mother and child. Data on seroprevalence and associated factors among pregnant women in Dawuro or surrounding was scarce. Therefore, the aim of this study was to assess prevalence of hepatitis B virus and factors associated among pregnant women in Dawuro Zone. METHODS: Institution based cross-sectional study was conducted from 1st April to May 31, 2015 in Dawuro zone...
August 22, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28818032/prevention-strategy-for-father-to-child-transmission-of-hepatitis-b-virus-a-systematic-review-and-meta-analysis
#19
Hong-Lin Chen, Man-Li Zha, Gang Qin
OBJECTIVE: Father-to-child transmission (FTCT) occurs in infants born to hepatitis B virus (HBV) infected father. In this study, we aim to summarize the prevention strategy for FTCT of HBV by systematic review and meta-analysis. METHODS: PubMed and China Knowledge Resource Integrated Database were systematically searched. We systematically reviewed the prevention strategy for father, mother, and infant before, during pregnancy and after birth. We also examined trial sequential analysis (TSA) for the required information size (RIS)...
August 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28816860/management-of-chronic-hepatitis-b-in-pregnancy
#20
Jie Li, Matthew S Chang, Tram T Tran, Mindie H Nguyen
Chronic hepatitis B virus (HBV) infection due to mother-to-child transmission during the perinatal period remains an important global health problem. Despite standard passive-active immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine in neonates, up to 8.5% of newborns still acquire HBV infection. Thus, management of chronic HBV during pregnancy and strategies to prevent mother-to-child transmission are important steps in eradicating or reducing the global burden of chronic HBV infection...
October 2017: Journal of Clinical Gastroenterology
keyword
keyword
106426
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"