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hepatitis B virus infection in pregnancy

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https://www.readbyqxmd.com/read/27879486/prospective-interventional-study-of-tenofovir-in-pregnancy-to-prevent-vertical-transmission-of-hepatitis-b-in-highly-viremic-women
#1
Pierre O Sellier, Sarah Maylin, Béatrice Berçot, Dorothée Chopin, Amanda Lopes, Guy Simoneau, John Evans, Véronique Delcey, Jean-Louis Bénifla, François Simon, Jean-François Bergmann
BACKGROUND: The risk of vertical transmission of hepatitis B virus (HBV) increases as maternal HBV DNA increase, despite serovaccination to newborns. METHODS: From 1 July 2012 to 1 January 2016, all pregnant women in Lariboisiere Hospital, Paris, France, with HBV DNA of 5 log10 IU/ml and above were administered tenofovir from week 28 of pregnancy until delivery. HBV DNA was measured at months 1, 2 of tenofovir and at delivery. The newborns were serovaccinated, tested for hepatitis B surface antigen, hepatitis B core antibody (HBcAb)±HBV DNA, and hepatitis B surface antibody (HBsAb) when aged 9 months, and then 24 months...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27875320/association-of-chronic-hepatitis-b-virus-infection-with-preterm-birth-our-experience-and-meta-analysis
#2
Ai-Min Cui, Jian-Guo Shao, Hai-Bo Li, Yi Shen, Zhi-Xian Chen, Sheng Zhang, Zhao-Lian Bian, Gang Qin, Xiao-Yan Cheng
OBJECTIVES: To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB). METHODS: A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects...
November 22, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27873053/relationship-between-the-mechanism-of-hepatitis-b-virus-father-infant-transmission-and-pregnancy-outcome
#3
Ying Kong, Yi Liu, Xiaojing Liu, Na Li, Zirong Zhu, Aiyun Zhang, Jianxue Liu, Feng Ye, Shumei Lin
PURPOSE: This study examined the relationship between the mechanism of hepatitis B virus (HBV) father-infant transmission via reproductive cells and pregnancy outcome. METHODS: Abandoned in vitro fertilization (IVF) embryos of fathers with chronic HBV infection were taken as study objects. HBV mRNA in embryos was detected, and successfully transplanted embryos were followed up to determine the relationship between HBV-infected embryos and pregnancy outcome. RESULTS: HBV mRNA signals were detected in one embryo in the group with HBV-positive fathers; the positive rate was 1/18 (5...
November 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27866601/assessment-of-state-perinatal-hepatitis-b-prevention-laws
#4
Lindsay A Culp, Lisa Caucci, Nancy E Fenlon, Megan C Lindley, Noele P Nelson, Trudy V Murphy
INTRODUCTION: Identifying pregnant women with hepatitis B virus (HBV) infection for post-exposure prophylaxis of their infants is critical to preventing mother-to-child transmission of HBV infection. HBV infection in infancy results in premature death from chronic liver disease or cancer in 25% of affected infants. Universal screening of pregnant women for HBV infection is the standard of care, and in many states is supported by laws for screening and reporting these infections to public health...
December 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27852658/indications-for-antiviral-therapy-for-chronic-hepatitis-b-in-pregnant-mothers
#5
Eric Raeyoon Yoo, Ryan Babu Perumpail, George Cholankeril, Aijaz Ahmed
The use of antiviral therapy for chronic hepatitis B virus (HBV) infection in the setting of pregnancy needs to be individualised based on limited data. We report a case of a 34-year-old Korean-American woman with a history of pregnancy with emergent caesarean section due to prolonged labour in the setting of HBV e-antigen (HBeAg) positive chronic HBV with a pretreatment baseline HBV DNA level of 110000 000 million copies per mL. Her first delivery was complicated by mother-to-child transmission (MTCT) of HBV infection to her daughter despite standard active and passive immunoprophylaxis...
November 15, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27796133/vertical-transmission-of-hepatitis-b-virus-during-pregnancy-and-delivery-in-denmark
#6
Nina Weis, Susan Cowan, Sofie Hallager, Sandra Dröse, Lena Hagelskjær Kristensen, Karin Grønbæk, Jan Gerstoft, Lone G Madsen, Mette Rye Clausen, Suzanne Lunding, Britta D Tarp, Toke S Barfod, Stine Sloth, Dorte Kinggaard Holm, Jesper Jensen, Henrik Krarup
OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission...
October 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27795784/-seroprevalence-of-hbsag-in-pregnant-women-in-central-morocco
#7
Mohammed Sbiti, Hanane Khalki, Imane Benbella, Lhoussaine Louzi
Maternal-fetal transmission of hepatitis B virus (HBV) is a global public health problem leading to the implementation of strengthened prevention measures. Viral replication in HIV-positive mother, assessed based on HBeAg positivity and the rate of viral load, determines the contamination risk which is very important during perinatal period. Mothers with chronic HBV are a real reservoir of vertical transmission of this infection. This is a prospective investigation of 1120 pregnant Moroccan women aiming to study the seroprevalence of HBsAg which was 2...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27761922/urticarial-exanthema-due-to-hepatitis-b-in-a-pregnant-woman-mimicking-a-polymorphic-eruption-of-pregnancy
#8
B Lozano-Masdemont, L Gómez-Recuero-Muñoz, A Pulido-Pérez, I Molina-López, R Suárez-Fernández
Hepatitis B virus (HBV) infection in pregnant women is very rare in western countries, thus, cutaneous manifestation of HBV infection may be confused with a dermatosis specific of pregnancy. We report a 39-year-old woman who presented in her 20th week of pregnancy with a pruritic rash, which consisted of generalized erythematous plaques, some of them with a purple centre. Serology testing showed acute HBV infection, and a biopsy revealed a superficial and interstitial perivascular inflammatory infiltrate of lymphocytes and eosinophils...
October 20, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27749537/telbivudine-treatment-of-hepatitis-b-virus-infected-pregnant-women-at-different-gestational-stages-for-the-prevention-of-mother-to-child-transmission-outcomes-of-telbivudine-treatment-during-pregnancy
#9
Zhangmin Tan, Yuzhu Yin, Jin Zhou, Lingling Wu, Chengfang Xu, Hongying Hou
This prospective study evaluated the viability of telbivudine for blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) infection.Pregnant women positive for the hepatitis B surface antigen began telbivudine treatment before 14 weeks of gestation (i.e., early), between 14 and 28 weeks of gestation (late), or not at all (control). In the late-treatment group, 55 women terminated telbivudine therapy within puerperium. All neonates underwent routine hepatitis B immunoglobulin plus vaccination...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27742003/epidemiology-of-hepatitis-b-virus-infection-and-impact-of-vaccination-on-disease
#10
Noele P Nelson, Philippa J Easterbrook, Brian J McMahon
Integration of hepatitis B vaccination into national immunization programs has resulted in substantial reductions of hepatitis B virus (HBV) transmission in previously high endemic countries. The key strategy for control of the HBV epidemic is birth dose and infant vaccination. Additional measures include use of hepatitis B immunoglobulin (HBIG) and diagnosis of mothers at high risk of transmitting HBV and use of antiviral agents during pregnancy to decrease maternal DNA concentrations to undetectable concentrations...
November 2016: Clinics in Liver Disease
https://www.readbyqxmd.com/read/27630725/prevalence-of-hepatitis-b-and-c-viral-infection-among-pregnant-women-in-peshawar-pakistan
#11
Irshad Ahmad
BACKGROUND: Viral hepatitis during pregnancy is associated with a high risk of maternal complications. The virus has a high risk of vertical transmission and it has been reported as the leading cause of maternal death. OBJECTIVES: To study the prevalence of hepatitis B (HBV) and hepatitis C (HCV) viral infections among pregnant women in the Peshawar district of Pakistan. MATERIALS AND METHODS: The cross-sectional study took place between July 2013 and April 2014...
June 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27610014/hepatitis-e-discovery-global-impact-control-and-cure
#12
REVIEW
Mohammad S Khuroo, Mehnaaz S Khuroo, Naira S Khuroo
Hepatitis E was identified as an epidemic of non-A, non-B hepatitis from Kashmir, India in 1978. Hepatitis E virus (HEV), the etiological agent is the sole member of family Hepeviridae. The virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. Hepatitis E is a disease with a major global impact and has two distinct epidemiological patterns. Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults...
August 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27584606/prevalence-of-blood-borne-viruses-in-ivf-an-audit-of-a-fertility-centre
#13
Michael B Yakass, Bryan J Woodward, Mary A Otoo, Edem K Hiadzi
OBJECTIVE: The rate of infertility continues to be on the increase in the developing world. Similarly, the rates of blood-borne viral infections (BBVs) such as Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are also on this rise. In 2014, the World Health Organization (WHO) quoted prevalences of 1.5% (HIV), 15% (HBV) 1.3 - 8.4% (HCV) in the Ghanaian general population. It has been reported that BBVs can adversely affect male fertility, specifically sperm count and progressive motility...
2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27470623/-telbivudine-for-prevention-of-perinatal-transmission-in-pregnant-women-infected-with-hepatitis-b-virus-in-immune-tolerant-phase-a-study-of-efficacy-and-safety-of-drug-withdrawal
#14
Q J Sheng, Y Ding, B J Li, H Bai, C Zhang, C Han, Y X Fan, Y W Li, X G Dou
OBJECTIVE: To observe the success rate of telbivudine (LdT) for the prevention of perinatal transmission of hepatitis B virus (HBV) and the incidence of alanine aminotransferase (ALT) elevation during LdT treatment and after LdT withdrawal in HBV-infected pregnant woman with high viremia in immune-tolerant phase and receiving LdT treatment at the end of pregnancy, and to evaluate the efficacy of LdT in the prevention of perinatal transmission and the safety for pregnant women. METHODS: Pregnant women infected with HBV in immune-tolerant phase who had normal ALT levels (≤40 U/L) and high viremia (HBV DNA ≥6 log10 IU/ml) with positive HBeAg were enrolled as subjects...
April 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27467017/incidence-and-seroprevalence-of-hepatitis-e-virus-infection-in-pregnant-women-infected-with-hepatitis-b-virus-and-antibody-placental-transfer-in-infants
#15
Hongyu Huang, Chenyu Xu, Xuan Zhou, Lanhua Liu, Yimin Dai, Biao Xu, Jishi Yang, Tingmei Chen, Yali Hu, Yi-Hua Zhou
BACKGROUND: Hepatitis E has poor outcomes in pregnant women. Superinfection of hepatitis E virus (HEV) in patients infected with hepatitis B virus (HBV) may worsen liver disease. OBJECTIVES: To estimate the incidence and seroprevalence of HEV infection among HBV-infected pregnant women, to investigate the transplacental transfer of maternal anti-HEV IgG, and to compare the maternal and neonatal outcomes in anti-HEV positive and negative pregnant women. STUDY DESIGN: Totally 391 HBV-infected pregnant women were recruited from April 2012 to October 2014...
September 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27402337/a-national-survey-of-facilities-for-complainants-of-sexual-assault
#16
Rageshri Dhairyawan, Kate Shardlow, Michelle Carroll, Rachel Sacks
In 2006, a national survey demonstrated wide disparities in services offered to sexual assault complainants in the UK, most marked between sexual assault referral centres and non-sexual assault referral centres (police victim examination suites). With national standards introduced in 2009 and the expansion of sexual assault referral centres, we aimed to evaluate the current situation. A questionnaire based on the original 2006 survey, collecting data on population covered, access, funding, personnel, medical care and clinical governance was sent to all 44 UK sexual assault referral centres open in 2012...
July 8, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27399957/heterogeneity-in-testing-practices-for-infections-during-pregnancy-national-survey-across-switzerland
#17
Karoline Aebi-Popp, Christian Kahlert, Andri Rauch, Beatrice Mosimann, David Baud, Nicola Low, Daniel Surbek
QUESTION: Detection and treatment of infections during pregnancy are important for both maternal and child health. The objective of this study was to describe testing practices and adherence to current national guidelines in Switzerland. METHODS: We invited all registered practicing obstetricians and gynaecologists in Switzerland to complete an anonymous web-based questionnaire about strategies for testing for 14 infections during pregnancy. We conducted a descriptive analysis according to demographic characteristics...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27387022/virological-determinants-of-spontaneous-postpartum-e-antigen-seroconversion-and-surface-antigen-seroclearance-in-pregnant-women-infected-with-hepatitis-b-virus
#18
Yali Hu, Zhenhua Feng, Jingli Liu, Jie Chen, Shu Zhang, Yi-Hua Zhou
BACKGROUND AND AIMS: We investigated the virological factors predicting spontaneous postpartum hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) seroclearance in pregnant women infected with hepatitis B virus (HBV). METHODS: We invited 419 HBV infected women whose sera had been collected during their pregnancy from August 2002-July 2004 and archived at -30°C, to participate the follow-up in October 2009-March 2010. Various virological factors were determined and compared in women with or without the seroconversion and seroclearance...
April 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27235103/guidelines-for-risk-reduction-when-handling-gametes-from-infectious-patients-seeking-assisted-reproductive-technologies
#19
REVIEW
Sangita K Jindal, Richard G Rawlins, Charles H Muller, Erma Z Drobnis
According to the Americans with Disabilities Act (1990), couples with blood-borne viruses that lead to infectious disease cannot be denied fertility treatment as long as the direct threat to the health and safety of others can be reduced or eliminated by a modification of policies or procedures. Three types of infectious patients are commonly discussed in the context of fertility treatment: those with human immunodeficiency virus (HIV), hepatitis C or hepatitis B. Seventy-five per cent of hepatitis C or HIV positive men and women are in their reproductive years, and these couples look to assisted reproductive techniques for risk reduction in conceiving a pregnancy...
August 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27231001/retrospective-hepatitis-c-seroprevalence-screening-in-the-antenatal-setting-should-we-be-screening-antenatal-women
#20
Chloe Orkin, Anna Jeffery-Smith, Graham R Foster, C Y William Tong
OBJECTIVES: An unlinked anonymous seroprevalence study was conducted to estimate the prevalence of hepatitis C virus (HCV) infection in samples derived from antenatal clinic attendees at 2 East London Hospitals. An unexpectedly high HCV seroprevalence of 2.6% (1.2% viraemic) had been revealed during an unlinked study of the emergency department at 1 of these hospitals. DESIGN: 1000 stored residual samples were tested for HCV antibody (anti-HCV) and reactive samples were further tested for HCV RNA...
2016: BMJ Open
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