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Suicidality

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https://www.readbyqxmd.com/read/29775696/tph2-polymorphisms-across-the-spectrum-of-psychiatric-morbidity-a-systematic-review-and-meta-analysis
#1
REVIEW
Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booij
Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric morbidity. The aim of the present review is to integrate results from association studies between TPH2 single nucleotide polymorphisms (SNPs) and various psychiatric disorders, which we furthermore quantified with meta-analysis. We reviewed 166 studies investigating 69 TPH2 SNPs in a broad range of psychiatric disorders, including over 30,000 patients...
May 15, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29774076/the-human-somatostatin-receptor-type-2-as-an-imaging-and-suicide-reporter-gene-for-pluripotent-stem-cell-derived-therapy-of-myocardial-infarction
#2
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, Hubert Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M Verfaillie, Maurilio Sampaolesi, Christophe M Deroose
Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the body. One possible therapeutic application involves the use of these cells to treat myocardial infarction (MI), a condition where billions of cardiomyocytes (CMs) are lost. Although several protocols have been developed to differentiate PSCs towards CMs, none of these provide a completely pure population, thereby still posing a risk for neoplastic teratoma formation...
2018: Theranostics
https://www.readbyqxmd.com/read/29773997/first-and-subsequent-lifetime-alcoholism-and-mental-disorders-in-suicide-victims-with-reference-to-a-community-sample-the-lundby-study-1947-1997
#3
Cecilia Holmstrand, Mats Bogren, Cecilia Mattisson, Louise Brådvik
Background: Suicide victims have been found to frequently suffer from mental disorders, often more than one, and comorbidity has also been found to be a risk factor for suicide. The aim of the present study was to determine the first disorder and possible subsequent disorders in suicide victims during their lifetimes and to compare their development with the development of mental and alcohol use disorders (AUDs) in a community sample. Methods: The Lundby Study is a prospective longitudinal study of mental health in a general population comprising 3,563 subjects, including 68 suicide victims, followed by four field investigations from 1947 to 1997; mortality was monitored up to 2011...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29773489/county-level-trends-in-suicide-rates-in-the-u-s-2005-2015
#4
Lauren M Rossen, Holly Hedegaard, Diba Khan, Margaret Warner
INTRODUCTION: Understanding the geographic patterns of suicide can help inform targeted prevention efforts. Although state-level variation in age-adjusted suicide rates has been well documented, trends at the county-level have been largely unexplored. This study uses small area estimation to produce stable county-level estimates of suicide rates to examine geographic, temporal, and urban-rural patterns in suicide from 2005 to 2015. METHODS: Using National Vital Statistics Underlying Cause of Death Files (2005-2015), hierarchical Bayesian models were used to estimate suicide rates for 3,140 counties...
May 8, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29773097/polymorphism-in-rs2229783-of-the-alpha-1-xi-collagen-gene-is-associated-with-susceptibility-to-but-not-severity-of-kashin-beck-disease-in-a-northwest-chinese-han-population
#5
Xiao Wei Shi, Feng Zhang, Zhi Yan Li, Ai Li Lyu, Xiong Guo
A case-control study was conducted to investigate associations between organophosphate pesticide (OP) exposure, aggression, impulsivity, and attempted suicide. The purpose of this study was to explore whether genomic polymorphisms in the alpha 1(XI) collagen gene (COL11A1) were associated with the risk and severity of Kashin-Beck disease (KBD). Twenty-two single nucleotide polymorphisms (SNPs) in COL11A1 were genotyped in 274 KBD cases and 249 healthy controls using the Sequenom MassARRAY system. The expression of type XI collagen (COL11A) in the knee articular cartilage of 22 KBD patients and 21 controls was analyzed by immunohistochemistry...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772772/multiplicative-effects-of-social-and-psychological-risk-factors-on-college-students-suicidal-behaviors
#6
Shervin Assari
Less is known about the multiplicative effects of social and psychological risk and protective factors of suicidality on college campuses. The current study aimed to investigate the multiplicative effects of social (identifying oneself as gay/lesbian, financial difficulty, violence victimization, and religiosity) and psychological (anxiety, depression, problem alcohol use, drug use) and risk/protective factors on suicidal behaviors among college students in the United States. Using a cross-sectional design, the Healthy Mind Study (HMS; 2016⁻2017), is a national online survey of college students in the United States...
May 17, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29772281/geriatric-oncology-spirituality-and-palliative-care
#7
Lodovico Balducci
Cancer is a major cause of morbidity and mortality for older individuals. Palliative care is essential to improve the outcome of cancer treatment in terms of quality of life and treatment satisfaction. This review examines the influence of spirituality on aging in general and on the management of older cancer patients. A spiritual perspective has been associated with successful aging, and with better tolerance of physical and emotional stress, including the ability to cope with serious diseases and with isolation...
May 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29772072/the-forensic-confirmation-bias-a-comparison-between-experts-and-novices
#8
Claire A J van den Eeden, Christianne J de Poot, Peter J van Koppen
A large body of research has described the influence of context information on forensic decision-making. In this study, we examined the effect of context information on the search for and selection of traces by students (N = 36) and crime scene investigators (N = 58). Participants investigated an ambiguous mock crime scene and received prior information indicating suicide, a violent death or no information. Participants described their impression of the scene and wrote down which traces they wanted to secure...
May 17, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29771990/parental-involvement-could-mitigate-the-effects-of-physical-activity-and-dietary-habits-on-mental-distress-in-ghanaian-youth
#9
Franklin N Glozah, Kwaku Oppong Asante, Nuworza Kugbey
INTRODUCTION: Parental involvement in physical activity and dietary habits have been found to play a substantial role in the mental health of young people. However, there is little evidence about the associations between parental involvement, health behaviours and mental health among Ghanaian youth. This study sought to examine the role of parental involvement in the association between physical activity, dietary habits and mental health among Ghanaian youth. METHODS: Data were obtained from the 2012 Ghana Global School-based Student Health Survey (GSHS)...
2018: PloS One
https://www.readbyqxmd.com/read/29771757/teaching-mental-health-first-aid-in-the-school-setting-a-novel-approach-to-improving-outcomes-for-common-adolescent-mental-disorders
#10
Laura M Hart, Georgina R Cox, Lucy Lees
PURPOSE OF REVIEW: Common adolescent mental disorders, such as depression, often go untreated and severely impact health and educational outcomes. The purpose of this review is to describe what is currently known about school-based mental health interventions and to describe a new intervention, Mental Health First Aid training. RECENT FINDINGS: Universal and selective prevention and treatment programmes have been widely evaluated, though population-level dissemination remains elusive...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29771611/firearm-ownership-storage-practices-and-suicide-risk-factors-in-washington-state-2013-2016
#11
Erin Renee Morgan, Anthony Gomez, Ali Rowhani-Rahbar
OBJECTIVES: To characterize firearm ownership and storage practices in Washington State and assess their relationship with suicide risk factors. METHODS: Using Washington State Behavioral Risk Factor Surveillance System data for 2013 to 2016, we conducted survey-weighted multivariable Poisson regression models to obtain prevalence ratios (PRs) and confidence intervals (CIs). RESULTS: Of 34 884 adult respondents, 34.3% (95% CI = 33.7%, 35...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29771181/association-of-temporomandibular-disorder-and-high-frequency-of-suicide-ideation-in-korean-adolescents-a-cross-sectional-survey
#12
Hyun A Heo, Suhyun Park, Sung Woon Pyo
BACKGROUND: This study investigated the association between psychological factors and temporomandibular disorder (TMD) in a representative sample using data from the Korean nationwide survey. METHODS: The study included 1337 adolescents. Participants provided demographic, socio-economic and behavioural information, and responses to questionnaires assessing their mental health status including perceived stress, depressed mood and suicidal ideation in the presence of TMD...
May 17, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29769367/similarities-between-military-and-medical-service-stigma-of-seeking-mental-health-assistance
#13
EDITORIAL
Fergus Gardiner, E C Gardiner
Studies have identified that there are many barriers to treatment of mental health illnesses in military populations, including the negative-associated stigma. One such barrier includes perceptions of weakness, leading to concerns about leadership and competency and being seen as malingering. Furthermore, similarities can be seen in civilian health professionals, where concerns of negative perceptions can limit reporting and treatment of mental health illnesses. Despite the frequency of stressful events, military and health professionals do not become immune to stress and are often ill prepared to cope with acute stressors that can often build on each other until emotional exhaustion and/or crisis point...
May 16, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29769319/repeated-exposure-of-epithelial-cells-to-apoptotic-cells-induces-the-specific-selection-of-an-adaptive-phenotype-implications-for-tumorigenesis
#14
Lanfei Feng, Snezana Vujicic, Michael E Dietrich, Natalia Litbarg, Suman Setty, Angelika Antoni, Joyce Rauch, Jerrold S Levine
The consequences of apoptosis extend beyond mere death of the cell. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) inhibits PTEC proliferation, growth, and survival. Here we tested the hypothesis that continual exposure to apoptotic targets can induce a phenotypic change in responding PTECs, as in other instances of natural selection. In particular, we demonstrate that repeated exposure to apoptotic targets leads to emergence of a PTEC line (denoted BU...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29769243/hospitalization-for-suicide-ideation-or-attempt-2008-2015
#15
Gregory Plemmons, Matthew Hall, Stephanie Doupnik, James Gay, Charlotte Brown, Whitney Browning, Robert Casey, Katherine Freundlich, David P Johnson, Carrie Lind, Kris Rehm, Susan Thomas, Derek Williams
OBJECTIVES: Suicide ideation (SI) and suicide attempts (SAs) have been reported as increasing among US children over the last decade. We examined trends in emergency and inpatient encounters for SI and SA at US children's hospitals from 2008 to 2015. METHODS: We used retrospective analysis of administrative billing data from the Pediatric Health Information System database. RESULTS: There were 115 856 SI and SA encounters during the study period...
May 16, 2018: Pediatrics
https://www.readbyqxmd.com/read/29768664/a-four-year-longitudinal-study-examining-psychache-and-suicide-ideation-in-elevated-risk-undergraduates-a-test-of-shneidman-s-model-of-suicidal-behavior
#16
Vanessa Montemarano, Talia Troister, Christine E Lambert, Ronald R Holden
OBJECTIVES: Using a 4-year follow-up design, this research investigated Shneidman's model of psychache (i.e., intense mental pain/anguish) as the cause of suicide. Operationalizing suicidal manifestations using suicide ideation, we evaluated Shneidman's assertion that psychache is the prominent predictor of suicide ideation and that other suicide-related psychological variables associate with suicide ideation only through psychache. METHOD: Eighty-two undergraduates at elevated suicide risk were assessed at baseline and follow-up with measures of suicide ideation and three psychological predictors: depression, hopelessness, and psychache...
May 16, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29768303/post-mortem-analysis-of-suicide-victims-shows-abcb1-haplotype-1236t-2677t-3435t-as-a-candidate-predisposing-factor-behind-adverse-drug-reactions-in-females-erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29767826/accidental-or-intentional-exposure-to-potentially-toxic-medications-natural-toxins-and-chemicals-during-pregnancy-analysis-of-data-from-tox-info-suisse
#18
Tabea Vogel, Saskia Lüde, Rahel Baumgartner, Christine Rauber-Lüthy, Ana Paula Simões-Wüst
OBJECTIVE: Affected women and health professionals are still often unsure about how to react to exposures to potentially harmful agents during pregnancy. We wanted to find out which agents worry both pregnant women and professionals, under what circumstances the exposures take place, how they are currently dealt with and how serious they are. METHODS: Making use of the archives of Tox Info Suisse, the foundation that provides poisons information in Switzerland both for members of the general public and for healthcare professionals, we set up an analysis of exposures to possibly harmful agents during pregnancy...
May 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29767823/the-validity-of-open-source-data-when-assessing-jail-suicides
#19
Amanda L Thomas, Jacqueline Scott, Jeff Mellow
BACKGROUND: The Bureau of Justice Statistics' Deaths in Custody Reporting Program is the primary source for jail suicide research, though the data is restricted from general dissemination. This study is the first to examine whether jail suicide data obtained from publicly available sources can help inform our understanding of this serious public health problem. METHODS: Of the 304 suicides that were reported through the DCRP in 2009, roughly 56 percent (N = 170) of those suicides were identified through the open-source search protocol...
May 9, 2018: Health & Justice
https://www.readbyqxmd.com/read/29767457/suicidal-behavior-and-personality-traits-contribute-to-disability-in-first-episode-psychosis-a-1-year-follow-up-study
#20
Manuel Canal-Rivero, Javier-David Lopez-Moriñigo, Maria-Luisa Barrigón, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla, Jordi E Obiols-Llandrich
BACKGROUND: Disability encompasses impairments, activity limitations, and restrictions on participation. Improvement in functioning has therefore become a crucial outcome of treatment in psychosis. OBJECTIVE: The main aim of this study was to analyze the potential relationship between suicidal behavior after first episode of psychosis (FEP) and family disability. The second aim was to find out whether personality traits are associated with disability dimensions...
May 16, 2018: Suicide & Life-threatening Behavior
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