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https://www.readbyqxmd.com/read/28345376/lessons-from-metabonomics-on-the-neurobiology-of-stroke
#1
Mahim I Qureshi, Panagiotis A Vorkas, Alexander P Coupland, I Harri Jenkins, Elaine Holmes, Alun H Davies
The application of metabonomic science to interrogate stroke permits the study of metabolite entities, small enough to cross the blood-brain barrier, that provide insight into neuronal dysfunction, and may serve as reservoirs of biomarker discovery. This systematic review examines the applicability of metabolic profiling in ischemic stroke research. Six human studies utilizing metabolic profiling to analyze biofluids from ischemic stroke patients have been included, employing (1)H-NMR and/or mass spectrometry to analyze plasma, serum, and/or urine in a targeted or untargeted fashion...
October 1, 2016: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28343466/treatment-of-gambling-disorder-patients-with-comorbid-depression
#2
Jakob Linnet, Monique Jeppsen Mensink, Johanne de Neergaard Bonde, Michael Winterdahl
OBJECTIVE: This study was conducted to investigate and clinically assess comorbid depression and its relevance in individuals suffering from gambling disorders. The DSM-V defines the condition of gambling disorder as a persistent and recurrent problematic gambling behaviour leading to clinically significant impairment or distress. METHOD: A total of 61 subjects with gambling disorders were assessed using the Structured Clinical Interview for the DSM-IV (SCID-I), the South Oaks Gambling Screen (SOGS) and the Major Depression inventory (MDI)...
March 27, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28342944/the-anti-inflammatory-mechanism-of-antidepressants-ssris-snris
#3
REVIEW
Piotr Gałecki, Joanna Mossakowska-Wójcik, Monika Talarowska
The cytokine theory of depression no longer brings about any doubts. Experiments and research studies conducted in the last ten years have confirmed that both physical and psychological (emotional) stress increases the likelihood of occurrence of mental disorders (including depressive disorders) owing to the action of a series of hormonal and biochemical mechanisms. Selective serotonin reuptake inhibitors (SSRI) as well as serotonin and norepinephrine reuptake inhibitors (SNRIs) are some of the most commonly applied drugs in the world during pharmacotherapy of recurrent depressive disorder...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28341444/the-importance-of-tcf4-gene-in-the-etiology-of-recurrent-depressive-disorders
#4
Joanna Mossakowska-Wójcik, Agata Orzechowska, Monika Talarowska, Janusz Szemraj, Piotr Gałecki
BACKGROUND: A recurrent depressive disorder is one of the most commonly diagnosed disease entities among psychiatric disorders. The prevalence and morbidity of depression are constantly increasing. Numerous studies have demonstrated the role of genetic factors in the etiology of depressive disorders. Many studies are being conducted to identify genes that predispose to depression. The purpose of this study was to investigate the role of TCF4 gene in the etiology of recurrent depressive disorders and, in particular, to assess expression of the TCF4 gene at the mRNA and protein level in patients with recurrent depressive disorders versus healthy individuals...
March 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28338644/clinical-hypnosis-an-effective-mind-body-modality-for-adolescents-with-behavioral-and-physical-complaints
#5
REVIEW
Anju Sawni, Cora Collette Breuner
Mind-body medicine is a system of health practices that includes meditation/relaxation training, guided imagery, hypnosis, biofeedback, yoga, art/music therapy, prayer, t'ai chi, and psychological therapies such as cognitive behavioral therapy. Clinical hypnosis is an important mind-body tool that serves as an adjunct to conventional medical care for the adolescent patient. Clinical hypnosis specifically uses self-directed therapeutic suggestions to cultivate the imagination and facilitate the mind-body connection, leading to positive emotional and physical well-being...
March 24, 2017: Children
https://www.readbyqxmd.com/read/28333778/cochlear-implant-in-severe-impaired-psychiatric-patients-a-case-series
#6
Ioana T Herisanu, Mark Praetorius, Margarete Mattern
OBJECTIVE: Psychotic disorders and intelligence deficiencies are no longer contraindications for cochlear implantation regarding the revised German guidelines from May 2012. This article aims to evaluate the outcome of patients with severe psychiatric comorbidities. Therefore the database of the Cochlear Implant Center of the University Hospital of Heidelberg was investigated. STUDY DESIGN: Retrospective case review. METHODS: We present three patients who received a cochlear implant (CI) despite a serious psychiatric disorder...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28331323/bipolar-disorder-recurrence-prevention-using-self-monitoring-daily-mood-charts-case-reports-from-a-5-year-period
#7
Norio Yasui-Furukori, Kazuhiko Nakamura
Mood symptoms in bipolar disorders are significantly related to psychosocial events, and the personalized identification of symptom triggers is important. Ecological momentary assessments have been used in paper-and-pencil form to explore emotional reactivity to daily life stress in patients with bipolar disorder. However, there are few data on long-term recurrence prevention effects using ecological momentary assessments. Subjects were three outpatients with bipolar disorder who had a history of at least one admission...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28331011/rates-and-correlates-of-suicidal-ideation-among-stroke-survivors-a-meta-analysis
#8
Francesco Bartoli, Maurizio Pompili, Nicoletta Lillia, Cristina Crocamo, Giuseppe Salemi, Massimo Clerici, Giuseppe Carrà
BACKGROUND: A better understanding of the epidemiological impact of suicidal ideation after stroke is required to identify subjects needing personalised interventions. OBJECTIVE: The aim of this meta-analysis was to estimate rates and correlates of suicidal ideation among stroke survivors. METHODS: We searched via Ovid, Medline, Embase and PsycInfo from database inception until August 2016. Predefined outcomes were (1) rates of suicidal ideation based on random-effects pooled proportion and (2) relevant sociodemographic and clinical correlates, using random-effects odds ratio (OR) or standardised mean difference (SMD) for categorical and continuous variables, respectively...
March 22, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28324266/quality-of-life-in-patients-with-recurrent-breast-cancer-after-second-breast-conserving-therapy-in-comparison-with-mastectomy-the-german-experience
#9
Svenja Jendrian, Katharina Steffens, Barbara Schmalfeldt, Elena Laakmann, Corinna Bergelt, Isabell Witzel
BACKGROUND: Although some studies suggest that breast-conserving therapy (BCT) shows better psychosocial outcomes than mastectomy in patients with primary breast cancer, little is known about the outcomes of these surgical options in recurrent breast cancer. We investigated differences in overall survival and re-recurrence rates as well as psychosocial outcomes among patients who underwent BCT or mastectomy after the diagnosis of recurrent breast cancer in a single-center setting. METHODS: 124 of 186 eligible patients who underwent surgical treatment for breast cancer recurrence completed the questionnaires on quality of life (EORTC QLQ-C30 and -BR23), fear of progression (PA-F-KF), anxiety and depression (HADS), and body image (BIS)...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28317221/psychological-and-clinical-correlates-of-posttraumatic-growth-in-cancer-a-systematic-and-critical-review
#10
REVIEW
Anna Casellas-Grau, Cristian Ochoa, Chiara Ruini
OBJECTIVE: To describe major findings on posttraumatic growth (PTG) in cancer, by analyzing its various definitions, assessment tools, and examining its main psychological and clinical correlates. Methods A search in relevant databases (PsycINFO, Pubmed, ProQuest, Scopus and Web of Science) was performed using descriptors related to the positive reactions in cancer. Articles were screened by title, abstract and full-text. RESULTS: Seventy-two met the inclusion criteria...
March 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28298775/a-comparative-study-of-intravenous-dexmedetomidine-and-intravenous-clonidine-for-postspinal-shivering-in-patients-undergoing-lower-limb-orthopedic-surgeries
#11
Manohar Panneer, Prakash Murugaiyan, Sufala Viswas Rao
BACKGROUND: Dexmedetomidine and clonidine have been used for the prevention and treatment of shivering following spinal blockade. A prospective randomized, double-blinded study was conducted to compare the efficacy and safety of dexmedetomidine and clonidine in controlling postspinal shivering. METHODS: A total of sixty participants of equal sex, aged between 18 and 60 years of American Society of Anesthesiologists (ASA) I/II Class, who underwent orthopedic lower limb surgeries under spinal anesthesia with ≥Grade III shivering were randomly divided into two groups, Group D (n = 30) received injection dexmedetomidine 0...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28298187/icanadapt-early-protocol-randomised-controlled-trial-rct-of-clinician-supervised-transdiagnostic-internet-delivered-cognitive-behaviour-therapy-icbt-for-depression-and-or-anxiety-in-early-stage-cancer-survivors-vs-treatment-as-usual
#12
M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith, G Andrews
BACKGROUND: This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/DESIGN: Early stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28297595/decreased-resting-state-activity-in-the-precuneus-is-associated-with-depressive-episodes-in-recurrent-depression
#13
Chun-Hong Liu, Xin Ma, Zhen Yuan, Lu-Ping Song, Bing Jing, Hong-Yu Lu, Li-Rong Tang, Jin Fan, Martin Walter, Cun-Zhi Liu, Lihong Wang, Chuan-Yue Wang
OBJECTIVE: To investigate alterations in resting-state spontaneous brain activity in patients with major depressive disorder (MDD) experiencing multiple episodes. METHODS: Between May 2007 and September 2014, 24 recurrent and 22 remitted patients diagnosed with MDD with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), and 69 healthy controls matched for age, sex, and educational level participated in this study. Among them, 1 healthy control was excluded due to excessive head motion...
March 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28293319/character-and-temperament-dimensions-in-subjects-with-depressive-disorder-impact-of-the-affective-state-on-their-expression
#14
Stojan Bajraktarov, Antoni Novotni, Slavica Arsova, Dance Gudeva-Nikovska, Viktorija Vujovik
BACKGROUND: The depression is a cross-cultural condition that occurs in all cultures and within all nations with certain specificities, even though there are some differences in its manifestation. The hereditary load is of major importance, but also the individual personality factors, in the form of risk factors, are associated with the occurrence of depression. Personality characteristics have a significant impact on the occurrence of the recurrent depressive disorder and the outcome of the treatment as well...
March 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28293023/advances-in-image-enhancement-in-colonoscopy-for-detection-of-adenomas
#15
REVIEW
Takahisa Matsuda, Akiko Ono, Masau Sekiguchi, Takahiro Fujii, Yutaka Saito
High-quality colonoscopy is mandatory to prevent adenoma recurrence and colorectal cancer. In the past few years, technical advances have been developed with the purpose of improving adenoma detection rate (ADR), one of the most important validated colonoscopy quality benchmarks. Several techniques or devices are used to optimize visualization: observation techniques; add-on devices; auxiliary imaging devices; colonoscopes with increased field of view; and colonoscopes with an integrated inflatable reusable balloon...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28291258/adult-hippocampal-neuroplasticity-triggers-susceptibility-to-recurrent-depression
#16
N D Alves, J S Correia, P Patrício, A Mateus-Pinheiro, A R Machado-Santos, E Loureiro-Campos, M Morais, J M Bessa, N Sousa, L Pinto
Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28291040/treatment-of-depersonalization-disorder-with-repetitive-transcranial-magnetic-stimulation
#17
Bianca C Karris, Marc Capobianco, Xin Wei, Lesley Ross
High frequency repetitive transcranial magnetic stimulation (rTMS) was approved by the US Food and Drug Administration in 2008 to treat major depressive disorder in those who did not respond to at least 1 antidepressant trial. Previous studies have shown that both high frequency rTMS to the left dorsolateral prefrontal cortex (DLPFC) and low frequency rTMS to the right DLPFC have antidepressant efficacy in treatment-resistant depression. Although rTMS has been widely used in the treatment of depression, very few studies of rTMS in patients with depersonalization disorder (DPD) have been published so far...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28290763/psychosocial-risk-factors-and-treatment-of-new-onset-and-recurrent-depression-during-the-post-partum-period
#18
Pirjo Kettunen, Jukka Hintikka
BACKGROUND: When developing maternity care services, it is important to know how psychosocial factors affect the course of post-partum depression (PPD), and how depressed mothers are treated. AIMS: The aim of this study is to assess how adverse childhood experiences, poor present support and violence, and low socioeconomic status (SES) associate with PPD, specifically in new onset and recurrent post-partum depression. The second aim is to assess the treatment received for PPD...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28288158/stimulus-specific-adaptation-in-a-recurrent-network-model-of-primary-auditory-cortex
#19
Tohar S Yarden, Israel Nelken
Stimulus-specific adaptation (SSA) occurs when neurons decrease their responses to frequently-presented (standard) stimuli but not, or not as much, to other, rare (deviant) stimuli. SSA is present in all mammalian species in which it has been tested as well as in birds. SSA confers short-term memory to neuronal responses, and may lie upstream of the generation of mismatch negativity (MMN), an important human event-related potential. Previously published models of SSA mostly rely on synaptic depression of the feedforward, thalamocortical input...
March 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28286705/negative-self-referential-processing-predicts-the-recurrence-of-major-depressive-episodes
#20
Joelle LeMoult, Katharina Kircanski, Gautam Prasad, Ian H Gotlib
Most individuals who develop Major Depressive Disorder (MDD) will experience a recurrent depressive episode; we know little, however, about cognitive mechanisms that increase the likelihood of recurrence. In the current study we examined whether negatively biased self-referential processing, negative life events, baseline depressive symptoms, and psychotropic medication use predicted the onset of a subsequent depressive episode in a longitudinal study of women with a history of recurrent MDD. Higher levels of depressive symptoms at baseline predicted experiencing a greater number of negative life events which, in turn, tended to predict recurrence of depression...
January 2017: Clinical Psychological Science
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