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https://www.readbyqxmd.com/read/28928869/hes1-promotes-colorectal-cancer-cell-resistance-to-5-fu-by-inducing-of-emt-and-abc-transporter-proteins
#1
Lei Sun, Jia Ke, Zhen He, Zexian Chen, Qinghua Huang, Wenjia Ai, Guoqiang Wang, Yisheng Wei, Xiangcai Zou, Shi Zhang, Ping Lan, Chuyuan Hong
Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream transcriptional factor of Notch signaling pathway, which was found to be related to chemoresistance. This study was aimed to investigate the role of HES1 in chemoresistance of colorectal cancer (CRC). Methods: Tissue microarray was used to analyze the clinical significance of HES1 in radical resected (R0) stage II/III CRC patients that received adjuvant chemotherapy. 5-fluorouracil (5-Fu) chemoresistance was examined in CRC cell lines (RKO and HCT8, LOVO) with stable over-expression and inhibition of HES1 gene by cytotoxicity test...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927429/the-impact-of-lipoprotein-lipase-deficiency-on-health-related-quality-of-life-a-detailed-structured-qualitative-study
#2
Sasi Neelamekam, See Kwok, Rachel Malone, Anthony S Wierzbicki, Handrean Soran
BACKGROUND: Lipoprotein lipase deficiency (LPLD) is an autosomal recessive inherited disorder caused by loss-of-function mutations in genes involved in the lipoprotein lipase pathway. It is characterised by chylomicronaemia, severe hypertriglyceridaemia and an increased risk of recurrent pancreatitis that often requires hospitalisation. This research aimed to improve our understanding of the debilitating impact that LPLD has on the daily lives of patients and their families. METHODS: The research comprised a 2-h interview with the patient and, where possible, a 1-h interview with a family member; a 1-week pre- and post-interview task (written and/or video diary); and a 30-45-min follow-up telephone interview...
September 19, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28926830/a-distinctive-ictal-amplitude-integrated-electroencephalography-pattern-in-newborns-with-neonatal-epilepsy-associated-with-kcnq2-mutations
#3
Ana Vilan, José Mendes Ribeiro, Pasquale Striano, Sarah Weckhuysen, Lauren C Weeke, Eva Brilstra, Linda S de Vries, Maria Roberta Cilio
BACKGROUND: Recurrent and prolonged seizures are harmful for the developing brain, emphasizing the importance of early seizure recognition and effective therapy. Amplitude-integrated electroencephalography (aEEG) has become a valuable tool to diagnose epileptic seizures, and, in parallel, genetic etiologies are increasingly being recognized, changing the paradigm of the workup and management of neonatal seizures. OBJECTIVE: To report the ictal aEEG pattern in neonates with KCNQ2-related epilepsy...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28924438/central-retinal-vein-occlusion-in-2-patients-using-antipsychotic-drugs
#4
Koichiro Taki, Teruyo Kida, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: To report our findings in 2 patients who developed a central retinal vein occlusion (CRVO) and were chronic users of antipsychotic medications. CASE PRESENTATION: Case 1 was a 62-year-old woman who had a sudden reduction of vision in her right eye to 20/2,000. Her fundus showed signs of an impending CRVO with marked macular edema. She had been taking antipsychotic drugs (quetiapine fumarate and risperidone) for about 2 years. She refused anti-VEGF therapy for her macular edema but selected systemic kallidinogenase...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28920096/competition-effects-in-visual-cortex-between-emotional-distractors-and-a-primary-task-in-remitted-depression
#5
Mary L Woody, Vladimir Miskovic, Max Owens, Kiera M James, Cope Feurer, Effua E Sosoo, Brandon E Gibb
BACKGROUND: Attentional biases, particularly difficulty inhibiting attention to negative stimuli, are implicated in risk for major depressive disorder (MDD). The current study examined a neural measure of attentional bias using a continuous index of visuocortical engagement (steady-state visual evoked potentials [SSVEPs]) before and after a negative mood induction in a population at high-risk for MDD recurrence due to a recently remitted MDD (rMDD) episode. Additionally, we examined working memory (WM) capacity as a potential moderator of the link between rMDD and visuocortical responses...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28918241/stigma-experienced-by-patients-with-severe-mental-disorders-a-nationwide-multicentric-study-from-india
#6
Sandeep Grover, Ajit Avasthi, Aakanksha Singh, Amitava Dan, Rajarshi Neogi, Darpan Kaur, Bhavesh Lakdawala, Abhijit R Rozatkar, Naresh Nebhinani, Suravi Patra, Priya Sivashankar, Alka A Subramanyam, Adarsh Tripathi, Ab Majid Gania, Gurvinder Pal Singh, Prakash Behere
This study aimed to evaluate the stigma and its correlates among patients with severe mental disorders. Patients with diagnosis of schizophrenia (N = 707), bipolar disorder (N = 344) and recurrent depressive disorder (N = 352) currently in clinical remission from 14 participating centres were assessed on Internalized Stigma of Mental Illness Scale (ISMIS). Patients with diagnosis of schizophrenia experienced higher level of alienation, sterotype endorsement, discrimination experience and total stigma when compared to patients with bipolar disorder and recurrent depressive disorder...
August 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918186/health-related-quality-of-life-in-melanoma-patients-impact-of-melanoma-related-limb-lymphoedema
#7
Caroline A Gjorup, Mogens Groenvold, Helle W Hendel, Karin Dahlstroem, Krzysztof T Drzewiecki, Tobias W Klausen, Lisbet R Hölmich
AIM: To explore health-related quality of life (HRQoL) in recurrence-free melanoma patients, with a focus on the association between melanoma-related limb lymphoedema and HRQoL. METHODS: HRQoL was evaluated using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the breast cancer module (EORTC QLQ-BR23) subscales body image and future perspective, the Functional Assessment for Cancer Therapy-General subscale social/family well-being and the Hospital Anxiety and Depression Scale...
September 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28902564/relations-of-shared-and-unique-components-of-personality-and-psychosocial-functioning-to-depressive-symptoms
#8
Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett
Consistent with theories of depression, several personality (e.g., high neuroticism, low extraversion) and psychosocial (e.g., interpersonal problems, cognitive content) variables predict depressive symptoms substantively. In this extended replication, we clarified whether 13 theoretically relevant personality and psychosocial variables were unique versus overlapping predictors of symptoms among 351 adult outpatients with recurrent major depressive disorder who received acute-phase cognitive therapy (CT). Using factor analysis and regression methods, we partitioned the measures' variance into general components common across the two types of measures (psychosocial and personality), within-type components shared only with other measures of the same type, and scale-specific components...
September 13, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28901656/the-effects-of-seasonal-affective-disorder-and-alcohol-abuse-on-sleep-and-snoring-functions-in-a-population-based-study-in-finland
#9
Isabel Morales-Muñoz, Seppo Koskinen, Timo Partonen
Seasonal affective disorder (SAD) is a recurrent depressive disorder with a seasonal pattern. In addition to some specific symptoms such as sad mood, low energy or carbohydrate craving, this mood disorder is also characterized by the presence of sleeping problems and alcohol disorders. Interestingly, there is a strong link between alcohol use and sleeping deficits. Although previous studies have focused extensively on the sleep patterns in SAD patients and patients with alcohol use disorder (AUD), no research has yet been conducted on subjects with comorbid SAD and AUD...
September 13, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28892932/comparison-of-effect-of-lavandula-officinalis-and-venlafaxine-in-treating-depression-a-double-blind-clinical-trial
#10
Masoud Nikfarjam, Reza Rakhshan, Hourivash Ghaderi
INTRODUCTION: Major depressive disorder is a chronic disease which may be associated with other mental illnesses. Lavandula officinalis and venlafaxine, herbal and chemical drugs respectively, are used to treat depression. Despite pharmacotherapy, major depressive disorder has a complicated pattern of resistance and recurrence. AIM: The aim of this study was to determine the effect of L. officinalis and venlafaxine in treating depression. MATERIALS AND METHODS: For this study, 120 patients referred to the psychiatry clinic of the Shahrekord University of Medical Sciences, Shahrekord, Iran, were randomly selected...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892767/negative-bias-in-expression-related-mismatch-negativity-mmn-in-remitted-late-life-depression-an-event-related-potential-study
#11
Zhangying Wu, Xiaomei Zhong, Qi Peng, Ben Chen, Naikeng Mai, Yuping Ning
Negative bias in cognition is closely associated with susceptibility to recurrent episodes of depression. Given the high recurrence rate of depression, previous studies have focused on the attentive level in late-life depression (LLD), but depression relapse is difficult to detect as a lower chief complaint in elderly people. Facial expression mismatch negativity (EMMN) is a tool that can measure cognitive bias in pre-attentive processing. In this study, we sought to explore the cognitive bias in pre-attentive emotional information processing in LLD...
August 31, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28890527/microvascular-angina%C3%A3-long-term-exercise-stress-test-follow-up
#12
Gaetano A Lanza, Monica Filice, Antonio De Vita, Angelo Villano, Laura Manfredonia, Priscilla Lamendola, Filippo Crea
BACKGROUND: A sizeable proportion of patients with primary stable microvascular angina (MVA; exercise-induced angina, positive exercise stress test [EST], normal coronary arteries) have recurrent symptoms during follow-up. There have been no previous studies, however, on the long-term results of EST and their correlation with symptom outcome.Methods and Results:Follow-up EST was performed in 71 MVA patients at an average of 16.2 years (range, 5-25 years) from the first EST. Angina status was assessed on weekly frequency of angina episodes and nitroglycerin consumption and by whether symptoms had worsened, improved, or remained unchanged over time...
September 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28889845/effect-of-electroacupuncture-rehabilitation-in-transverse-myelitis-a-case-report
#13
Sriloy Mohanty, Rabin Lal Shrestha
A 32-year-old male diagnosed with transverse myelitis in 2013 came to our clinic in 2015 with complaints of paraplegia, sensory disturbances, pain, exertional dyspnea, poor quality of sleep, emotional instability, and depression. This was a recurrent attack that had been exacerbated by post-traumatic stress. Owing to pain and functional disabilities, he was struggling to actively participate in the treatment modalities offered at our center. A modified protocol of electroacupuncture was planned for a period of 21 days, every day, with each session lasting for 30 minutes...
August 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28889049/the-potential-impact-of-biochemical-mediators-on-telomere-attrition-in-major-depressive-disorder-and-implications-for-future-study-designs-a-narrative-review
#14
REVIEW
Andrei Manoliu, Oliver G Bosch, Janis Brakowski, Annette B Brühl, Erich Seifritz
BACKGROUND: Major depressive disorder (MDD) has been proposed to represent a "disease of premature aging", which is associated with certain biomarkers of cellular ageing and numerous other age-related diseases. Over the last decade, telomere length (TL) arose as a surrogate for cellular aging. Recent data suggests that TL might be reduced in patients with MDD, however, results are still inconclusive. This might be explained by the lack of assessment of potential biochemical mediators that are directly associated with telomere shortening and frequently observed in patients with MDD...
August 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28888269/depression-is-associated-with-recurrent-chest-pain-with-or-without-coronary-artery-disease-a-prospective-cohort-study-in-the-emergency-department
#15
Yeunjung Kim, Morgan Soffler, Summer Paradise, Qurat-Ul-Ain Jelani, James Dziura, Rajita Sinha, Basmah Safdar
BACKGROUND: Only a small fraction of acute chest pain in the emergency department (ED) is due to obstructive coronary artery disease (CAD). ED chest pain remains associated with high rates of recidivism, often in the presence of nonobstructive CAD. Psychological states such as depression, anxiety, and elevation of perceived stress may account for this finding. The objective of the study was to determine whether psychological states predict recurrent chest pain (RCP). METHODS: We conducted a prospective cohort study of low- to moderate-cardiac risk ED patients admitted to the Yale Chest Pain Center with acute chest pain...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28881069/person-centred-discharge-education-following-coronary-artery-bypass-graft-a-critical-review
#16
Melanie Rushton, Michelle Howarth, Maria J Grant, Felicity Astin
AIMS AND OBJECTIVES: This critical review examines the extent that individualised education helps reduce depression, anxiety and improves self-care for people who've undergone Coronary Artery Bypass Graft surgery (CABG). BACKGROUND: Individualised discharge planning is increasingly important following cardiac surgery due to recurrent admissions as well as the issue of anxiety and depression, often due to lack of preparation. The hospital to home transition is fundamental in the recovery process...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28867280/interaction-between-childhood-maltreatment-on-immunogenetic-risk-in-depression-discovery-and-replication-in-clinical-case-control-samples
#17
S Cohen-Woods, H L Fisher, D Ahmetspahic, K Douroudis, D Stacey, G M Hosang, A Korszun, M Owen, N Craddock, V Arolt, U Dannowski, G Breen, I W Craig, A Farmer, B T Baune, C M Lewis, R Uher, P McGuffin
Major depressive disorder (MDD) is a prevalent disorder with moderate heritability. Both MDD and interpersonal adversity, including childhood maltreatment, have been consistently associated with elevated inflammatory markers. We investigated interaction between exposure to childhood maltreatment and extensive genetic variation within the inflammation pathway (CRP, IL1b, IL-6, IL11, TNF, TNFR1, and TNFR2) in relation to depression diagnosis. The discovery RADIANT sample included 262 cases with recurrent DSM-IV/ICD-10 MDD, and 288 unaffected controls...
August 31, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28866716/blood-serum-concentrations-of-kynurenic-acid-in-patients-diagnosed-with-recurrent-depressive-disorder-depression-in-bipolar-disorder-and-schizoaffective-disorder-treated-with-electroconvulsive-therapy
#18
Marcin Olajossy, Bartosz Olajossy, Sebastian Wnuk, Emilia Potembska, Ewa Urbańska
OBJECTIVES: The aim of the present study was to compare blood serum kynurenic acid (KYNA) concentrations measured before ECT and after 1, 6 and 12 electroconvulsive treatment (ECT) sessions in patients with diagnoses of recurrent depressive disorder (RDD), depression in bipolar disorder (DBD) and schizoaffective disorder (SAD). METHODS: The study group comprised of 50 patients with ICD-10 diagnoses of RDD, DBD and SAD. Blood serum KYNA concentrations were determined and clinical assessment was performed using the MADRS and the GAF scale...
June 18, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28866715/the-effect-of-vitamin-d3-deficiency-on-the-severity-of-depressive-symptoms-overview-of-current-research
#19
REVIEW
Bogdan Stefanowski, Anna Zofia Antosik-Wójcińska, Łukasz Święcicki
Traditional methods of depression treatment with the use of pharmacotherapy with antidepressants have limited effectiveness. Biological, psychological and environmental causes of depressive disorders are known, but pathophysiology of depression has not been fully explained. Many factors and mechanisms play role in the pathophysiology of depression, one of which may be vitamin D3 deficiency. Deficiency or border level of vitamin D3 is fairly common in the general population and may occur even in one billion people globally...
June 18, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28866131/increased-emotional-reactivity-to-affective-pictures-in-patients-with-skin-picking-disorder-evidence-from-functional-magnetic-resonance-imaging
#20
Albert Wabnegger, Sonja Übel, Gerald Suchar, Anne Schienle
The predominant symptom of skin-picking disorder (SPD) is the recurrent picking of one's own skin, leading to tissue damage and discomfort. Psychological disorder models suggest an enhanced emotional reactivity in patients with SPD, which contributes to the maintenance of symptoms. This functional magnetic resonance imaging (fMRI) experiment analyzed both subjective and neuronal responses to affective pictures (categories: fear, disgust, happiness, neutral) in 19 women with SPD and 16 healthy controls. Also, affective traits (disgust, anxiety, depression) were assessed...
September 1, 2017: Behavioural Brain Research
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