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Depression recurrent

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https://www.readbyqxmd.com/read/29656270/reduced-integrity-of-the-uncinate-fasciculus-and-cingulum-in-depression-a-stem-by-stem-analysis
#1
Kartik D Bhatia, Luke A Henderson, Eugene Hsu, Mark Yim
INTRODUCTION: The subgenual cingulate gyrus (Brodmann's Area 25: BA25) is hypermetabolic in depression and has been targeted successfully with deep brain stimulation. Two of the white matter tracts that play a role in treatment response are the uncinate fasciculus (UF) and the cingulum bundle. The UF has three prefrontal stems, the most medial of which extends from BA25 (which deals with mood regulation) and the most lateral of which extends from the dorso-lateral prefrontal cortex (concerned with executive function)...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656261/young-adult-cognitive-ability-and-subsequent-major-depression-in-a-cohort-of-666-804-danish-men
#2
Gunhild Tidemann Christensen, Maarten Pieter Rozing, Erik Lykke Mortensen, Kaare Christensen, Merete Osler
BACKGROUND: Early life cognitive ability (CA) might influence the risk of developing major depression (MD). The aim was to investigate the association between young adult CA and subsequent MD in relation to different MD disease characteristics. METHODS: Information on CA was assessed at conscription board examinations 1957-1984 (mean age 19 years) and information on MD was based on hospital diagnosis retrieved from Danish Patient registers 1969-2015. Associations between CA and MD were examined using Cox regression analyses...
April 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29649793/long-term-effects-of-middle-ear-tendon-resection-on-middle-ear-myoclonic-tinnitus-hearing-and-hyperacusis
#3
Dong-Kee Kim, Jung Mee Park, Jung Ju Han, Yun Min Chung, Jung Min Kim, So Young Park, Shi Nae Park
OBJECTIVE: To evaluate the therapeutic effects of middle ear tendon resection (METR) on middle ear myoclonic tinnitus (MEMT) and to investigate its long-term effects on hearing and hyperacusis. MATERIALS AND METHODS: Thirty-seven patients with MEMT with a mean age of 33.2 ± 11.8 years were included in this study. METR was performed on all 37 MEMT patients (41 ears) between November 2004 and August 2016. The mean follow-up period was 16.1 months. We examined changes in tinnitus and accompanying stress and depression in patients after surgery, and examined the hearing changes and the occurrence of complications including hyperacusis...
April 12, 2018: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29643149/involvement-of-prokineticin-2-expressing-neutrophil-infiltration-in-5-fluorouracil-induced-aggravation-of-breast-cancer-metastasis-to-lung
#4
Soichiro Sasaki, Tomohisa Baba, Hayato Muranaka, Yamato Tanabe, Chiaki Takahashi, Seiichi Matsugo, Naofumi Mukaida
Adjuvant chemotherapy is used for human breast cancer patients, even after curative surgery of primary tumor, in order to prevent tumor recurrence primarily as a form of metastasis. However, anti-cancer drugs can accelerate metastasis in several mouse metastasis models. Hence, we examined the effects of post-surgical administration with 5-fluorouracil (5-FU), doxorubicin, and cyclophosphamide, on lung metastasis process, which developed after the resection of the primary tumor arising from the orthotopic injection of a mouse triple-negative breast cancer cell line, 4T1...
April 11, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29629664/impact-of-a-psycho-educational-team-in-early-breast-cancer-patients-coping-strategies-the-venere-project
#5
Federica Andreis, Fausto Meriggi, Claudio Codignola, Ilaria Frigoli, Tiziana Prochilo, Stefano Mutti, Alessandra Huscher, Michela Libertini, Brunella Di Biasi, Chiara Abeni, Chiara Ogliosi, Silvia Noventa, Luigina Rota, Chiara Pedrali, Alberto Zaniboni
AIMS AND BACKGROUND: The main purpose of our psycho-educational groups was to help women with breast cancer learn how to cope with the physical, emotional, and lifestyle changes associated with cancer as well as with medical treatments that can be painful and traumatic. With this study, we wanted to detect the effects that group action had on the women who participated in it. METHODS: We studied a total of 97 patients who participated in 13 psycho-education groups...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29628501/excitatory-and-inhibitory-synaptic-dysfunction-in-mania-an-emerging-hypothesis-from-animal-model-studies
#6
REVIEW
Yeunkum Lee, Yinhua Zhang, Shinhyun Kim, Kihoon Han
Bipolar disorder (BD) is a common psychiatric disorder characterized by recurrent mood swings between depression and mania, and is associated with high treatment costs. The existence of manic episodes is the defining feature of BD, during which period, patients experience extreme elevation in activity, energy, and mood, with changes in sleep patterns that together severely impair their ability to function in daily life. Despite some limitations in recapitulating the complex features of human disease, several rodent models of mania have been generated and characterized, which have provided important insights toward understanding its underlying pathogenic mechanisms...
April 9, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29625763/time-to-rethink-the-approach-to-recurrent-depression
#7
Giovanni A Fava
No abstract text is available yet for this article.
April 3, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29625762/effectiveness-of-preventive-cognitive-therapy-while-tapering-antidepressants-versus-maintenance-antidepressant-treatment-versus-their-combination-in-prevention-of-depressive-relapse-or-recurrence-drd-study-a-three-group-multicentre-randomised-controlled-trial
#8
Claudi L H Bockting, Nicola S Klein, Hermien J Elgersma, Gerard D van Rijsbergen, Christien Slofstra, Johan Ormel, Erik Buskens, Jack Dekker, Peter J de Jong, Willem A Nolen, Aart H Schene, Steven D Hollon, Huibert Burger
BACKGROUND: Keeping individuals on antidepressants after remission or recovery of major depressive disorder is a common strategy to prevent relapse or recurrence. Preventive cognitive therapy (PCT) has been proposed as an alternative to maintenance antidepressant treatment, but whether its addition would allow tapering of antidepressants or enhance the efficacy of maintenance antidepressant treatment is unclear. We aimed to compare the effectiveness of antidepressants alone, with PCT while tapering off antidepressants, or PCT added to antidepressants in the prevention of relapse and recurrence...
April 3, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29622276/prospective-assessment-of-patient-reported-outcomes-in-gynecologic-cancer-patients-before-and-after-pelvic-exenteration
#9
Shannon D Armbruster, Charlotte C Sun, Shannon N Westin, Diane C Bodurka, Lois Ramondetta, Larissa A Meyer, Pamela T Soliman
OBJECTIVE: Pelvic exenteration (PE) is a surgical procedure associated with significant morbidity offered to select women with locally advanced or recurrent gynecologic cancers. This ongoing study examines an array of patient-reported outcomes and satisfaction with PE. METHODS: Since February 2009, prospectively enrolled participants completed questionnaires evaluating body image (BIS), depression (CESD), social support (DUFSS), symptoms (MDASI), sexual function (SAQ), functional status (SF-12), quality of life (The Stoma-QOL), satisfaction with decision (SWD) and an investigator-designed survey at baseline, 6, and 12months after PE...
April 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29622043/aripiprazole-induced-sleep-related-eating-disorder-a-case-report
#10
Nobuyuki Kobayashi, Masahiro Takano
BACKGROUND: Sleep-related eating disorder is characterized by parasomnia with recurrent episodes of nocturnal eating or drinking during the main sleep period. Several drugs, including atypical antipsychotics, induce sleep-related eating disorder. However, aripiprazole has not previously been associated with sleep-related eating disorder. CASE PRESENTATION: A 41-year-old Japanese man visited our clinic complaining of depression. The patient was treated with sertraline, which was titrated up to 100 mg for 4 weeks...
April 5, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29619930/neurological-and-psychiatric-comorbidity-in-patients-with-heart-failure-risk-and-prognosis
#11
Kasper Adelborg
Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psychiatric comorbidities. However, the prognostic impact of depression and the role of heart failure as a risk factor for dementia and stroke are not fully understood.
 Denmark is well-known for its unique health registries...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619005/presence-of-anxiety-and-depression-symptoms-affects-the-first-time-treatment-efficacy-and-recurrence-of-benign-paroxysmal-positional-vertigo
#12
Wei Wei, Zahra N Sayyid, Xiulan Ma, Tian Wang, Yaodong Dong
Objectives: To investigate the possible effects of anxiety and/or depression symptoms on the treatment outcomes and recurrence of benign paroxysmal positional vertigo (BPPV). Methods: This is a retrospective study conducted at a single institution. 142 consecutive patients diagnosed with idiopathic BPPV at the Department of Otology in Shengjing Hospital of China Medical University between October 2016 and July 2017 were retrospectively reviewed. 127 patients were finally included in this study...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29616434/control-charts-for-monitoring-mood-stability-as-a-predictor-of-severe-episodes-in-patients-with-bipolar-disorder
#13
Maria D L A Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders, John R Geddes
BACKGROUND: Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an important clinical goal. This study investigates the ability of control chart methodology to predict manic and/or depressive episodes by applying Shewhart's control rules to weekly self-reported scores from mania and depression questionnaires. METHODS: Shewhart's control rules were applied to weekly self-reported scores from the Altman Self-Rating Mania Scale (ASRM) and the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS) collected from 2001 to 2012 as part of the OXTEXT programme...
April 4, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29608461/vilazodone-efficacy-in-subgroups-of-patients-with-major-depressive-disorder-a-post-hoc-analysis-of-four-randomized-double-blind-placebo-controlled-trials
#14
Susan Kornstein, Cheng-Tao Chang, Carl P Gommoll, John Edwards
The efficacy of antidepressants to treat major depressive disorder (MDD) varies by patient characteristics. This post-hoc analysis evaluated the effects of vilazodone across patient subgroups in adults with MDD. Data were pooled from four trials of vilazodone (NCT00285376, NCT00683592, NCT01473394, and NCT01473381). Mean change from baseline to week 8 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score, MADRS response (≥50% total score improvement), and MADRS remission (total score≤10) were analyzed in the pooled intent-to-treat population (vilazodone=1254, placebo=964) and in subgroups of patients categorized by sex, age, MDD duration, recurrent episodes, baseline MADRS total score, and current episode duration...
March 30, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#15
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29605826/triple-negative-breast-cancer-depends-on-sphingosine-kinase-1-sphk1-sphingosine-1-phosphate-s1p-sphingosine-1-phosphate-receptor-3-s1pr3-notch-signaling-for-metastasis
#16
Shushu Wang, Yueyang Liang, Wenxiao Chang, Baoquan Hu, Yi Zhang
BACKGROUND Triple negative breast cancer (TNBC) has a more aggressive recurrence. Previous reports have demonstrated that sphingosine kinase 1 (SphK1) is a crucial regulator of breast cancer progression. However, the correlation of SphK1 with clinical prognosis has been poorly investigated. Thus, we aimed to elaborate the role of SphK1 in TNBC metastasis. MATERIAL AND METHODS We first determined the level of SphK1 in breast cancer tissue samples and breast cancer cells. Furthermore, the expression of HER2 and phosphor-SphK1 (pSphK1) in human breast cancer tissue samples was determined by immunohistochemical analysis...
April 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29601654/predictors-of-anxiety-and-depression-two-years-following-treatment-in-uveal-melanoma-survivors
#17
Stephen L Brown, Laura Hope-Stone, Heinrich Heimann, Bertil Damato, Peter Salmon
BACKGROUND: We examined the role of post-treatment symptoms and functional problems, and of worry about recurrent disease (WREC), in predicting and probable anxiety and depression cases 24 months after diagnosis in survivors of posterior uveal melanoma (UM). We examined whether WREC mediates links between symptoms, functional problems, and probable anxiety and depression cases. METHODS: Prospective cohort study of 261 treated UM survivors 6, 12 and 24 months after diagnosis...
March 30, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29599848/the-co-creation-and-feasibility-of-a-compassion-training-as-a-follow-up-to-mindfulness-based-cognitive-therapy-in-patients-with-recurrent-depression
#18
Rhoda Schuling, Marloes Huijbers, Hetty Jansen, Renée Metzemaekers, Erik Van Den Brink, Frits Koster, Hiske Van Ravesteijn, Anne Speckens
The aim of this study was to assess the feasibility, acceptability and preliminary effectiveness of Mindfulness - Based Compassionate Living (MBCL) as a follow-up intervention to Mindfulness Based Cognitive Therapy in adults with recurrent depression. We conducted an uncontrolled study in 17 patients with recurrent depression, in two successive groups. The first group contained novices to compassion training ( N  = 14); in the second group, ten of these participated again, in addition to three new participants ( N  = 13)...
2018: Mindfulness
https://www.readbyqxmd.com/read/29595146/assessment-of-linear-and-nonlinear-complex-heartbeat-dynamics-in-subclinical-depression-dysphoria
#19
Alberto Greco, Simone Messerotti Benvenuti, Claudio Gentili, Daniela Palomba, Enzo Pasquale Scilingo, Gaetano Valenza
OBJECTIVE: Depression is one of the leading causes of disability worldwide. Most previous studies have focused on major depression, and studies on subclinical depression, such as those on so-called dysphoria, have been overlooked. Indeed, dysphoria is associated with a high prevalence of somatic disorders, and a reduction of quality of life and life expectancy. In current clinical practice, dysphoria is assessed using psychometric questionnaires and structured interviews only, without taking into account objective pathophysiological indices...
March 29, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29590315/association-of-brain-cortical-changes-with-relapse-in-patients-with-major-depressive-disorder
#20
Dario Zaremba, Katharina Dohm, Ronny Redlich, Dominik Grotegerd, Robert Strojny, Susanne Meinert, Christian Bürger, Verena Enneking, Katharina Förster, Jonathan Repple, Nils Opel, Bernhard T Baune, Pienie Zwitserlood, Walter Heindel, Volker Arolt, Harald Kugel, Udo Dannlowski
Importance: More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how relapse affects brain morphologic features during the course of MDD. Objective: To use structural magnetic resonance imaging to identify morphologic brain changes associated with relapse in MDD. Design, Setting, and Participants: In this longitudinal case-control study, patients with acute MDD at baseline and healthy controls were recruited from the University of Münster Department of Psychiatry from March 21, 2010, to November 14, 2014, and were reassessed from November 11, 2012, to October 28, 2016...
March 28, 2018: JAMA Psychiatry
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