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Metabolic and kidney stone

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https://www.readbyqxmd.com/read/28623397/different-effects-of-%C3%AE-linolenic-acid-gla-supplementation-on-plasma-and-red-blood-cell-phospholipid-fatty-acid-composition-and-calcium-oxalate-kidney-stone-risk-factors-in-healthy-subjects-from-two-race-groups-with-different-risk-profiles-pose-questions-about
#1
Allen L Rodgers, Dalielah Jappie-Mahomed, Paul J van Jaarsveld
Fatty acid (FA) composition of phospholipids in plasma and red blood cells (RBC) can influence calciuria, oxaluria and renal stone formation. In this regard, the ratio of arachidonic acid (AA) and its precursor linoleic acid (LA) appears to be important. Administration of γ-linolenic acid (GLA) has been shown to increase the concentration of dihomo-gamma linoleic acid (DGLA) relative to AA indicating that it may attenuate biosynthesis of the latter. Such effects have not been investigated in race groups having difference stone occurrence rates...
June 16, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28599030/pediatric-nephrolithiasis-a-review
#2
Tayaba Miah, Deepak Kamat
The incidence of pediatric nephrolithiasis is on the rise. The composition of kidney stones in children is different than in adults, as most stones in children have a composition of calcium oxalate and calcium phosphate mixed with a small amount of uric acid. The symptoms of pediatric nephrolithiasis are nonspecific. Computed tomography (CT) is the gold standard for diagnosis; however, because of radiation exposure associated with a CT scan, ultrasonography is also an accepted modality for the diagnosis. Extensive metabolic evaluation is important to rule out an underlying metabolic disorder...
June 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28587067/diet-induced-low-grade-metabolic-acidosis-and-clinical-outcomes-a-review
#3
Renata Alves Carnauba, Ana Beatriz Baptistella, Valéria Paschoal, Gilberti Helena Hübscher
Low-grade metabolic acidosis is a condition characterized by a slight decrease in blood pH, within the range considered normal, and feeding is one of the main factors that may influence the occurrence of such a condition. The excessive consumption of acid precursor foods (sources of phosphorus and proteins), to the detriment of those precursors of bases (sources of potassium, calcium, and magnesium), leads to acid-base balance volubility. If this condition occurs in a prolonged, chronic way, low-grade metabolic acidosis can become significant and predispose to metabolic imbalances such as kidney stone formation, increased bone resorption, reduced bone mineral density, and the loss of muscle mass, as well as the increased risk of chronic diseases such as type 2 diabetes mellitus, hypertension, and non-alcoholic hepatic steatosis...
May 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28575878/kidney-calculi-pathophysiology-and-as-a-systemic-disorder
#4
Arash Shadman, Bahar Bastani
The pathophysiology of urinary stone formation is complex, involving a combination of metabolic, genetic, and environmental factors. Over the past decades, remarkable advances have been emerged in the understanding of the pathogenesis, diagnosis, and treatment of calcium kidney calculi. For this review, both original and review articles were found via PubMed search on pathophysiology, diagnosis, and management of urinary calculi. These resources were integrated with the authors' knowledge of the field. Nephrolithiasis is suggested to be associated with systemic disorders, including chronic kidney insufficiency, hematologic malignancies, endocrine disorders, autoimmune diseases, inflammatory bowel diseases, bone loss and fractures, hypertension, type 2 diabetes mellitus, metabolic syndrome, and vascular diseases like coronary heart diseases and most recently ischemic strokes...
May 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28522341/systemic-and-ocular-fluid-compounds-as-potential-biomarkers-in-age-related-macular-degeneration
#5
REVIEW
Eveline Kersten, Constantin C Paun, Rosa L Schellevis, Carel B Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C W Klaver, Sascha Dammeier, Anneke I den Hollander, Eiko K de Jong
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy. They can also be useful in clinical practice for monitoring disease progression, evaluation of treatment efficacy and risk assessment in multifactorial diseases, such as age-related macular degeneration (AMD). AMD is a highly prevalent progressive retinal disorder for which multiple genetic and environmental risk factors have been described, but the exact etiology is not yet fully understood. Many compounds have been evaluated for their association with AMD...
May 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28491855/nephrolithiasis-in-elderly-population-effect-of-demographic-characteristics
#6
Emadoddin Moudi, Seyed Reza Hosseini, Ali Bijani
BACKGROUND: Kidney stone (nephrolithiasis) is one of the most common diseases. During the past several decades, its prevalence and incidence have increased markedly in elderly population. OBJECTIVES: This study was conducted to evaluate the risk factors for nephrolithiasis in elderly population. PATIENTS AND METHODS: This study was based on the Amirkola Health and Ageing Project (AHAP). Elderly people with kidney stones in every size, type and number were considered to be the case group and other subjects without a history of kidney stones served as control group...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28465866/kidney-stones-after-bariatric-surgery-risk-assessment-and-mitigation
#7
REVIEW
Pedro Mario Espino-Grosso, Benjamin Kirk Canales
Obesity is rampant across the spectrum of age, gender, and race in the Unites States. Paralleling this epidemic, kidney stone prevalence is also rising, affecting nearly 1 in 11 individuals. Bariatric surgical procedures, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), are the most effective weight loss options for morbidly obese or severely obese individuals with comorbidities. A number of studies have linked kidney stone development to bariatric surgical history, particularly RYGB, which portends up to a threefold increase in calcium oxalate stone risk compared with age-matched, obese controls...
March 1, 2017: Bariatric Surgical Practice and Patient Care
https://www.readbyqxmd.com/read/28460910/organic-acids-in-kakadu-plum-terminalia-ferdinandiana-the-good-ellagic-the-bad-oxalic-and-the-uncertain-ascorbic
#8
David J Williams, David Edwards, Sharon Pun, Mridusmita Chaliha, Brian Burren, Ujang Tinggi, Yasmina Sultanbawa
The phenolic ellagic acid (EA) is receiving increasing attention for its nutritional and pharmacological potential as an antioxidant and antimicrobial agent. The Australian native Kakadu plum (Terminalia ferdinandiana) fruit is an abundant source of this phytochemical. The fruit also contains large amounts of vitamin C (mainly as ascorbic acid, AA) and possibly the undesirable oxalic acid (OA). Regular consumption of high oxalate foods poses a variety of health risks in humans including interference with calcium absorption and kidney stone formation...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28460506/-clinical-characteristics-in-gout-patients-with-different-body-mass-index
#9
L D Ma, R X Sun, Y Xin, Y Wang, C G Li, T Liu, X Y Cheng, Z T Jia
Objective: Obesity is one of the risk factors for gout. The aim of the present study was to evaluate clinical characteristics of gout patients with different BMI. Methods: A total of 5 104 patients with gout were enrolled and divided into three groups according to the BMI. The clinical information was collected and relevant biochemical indices were detected. SPSS software was applied for the statistical analyses. Results: There were significant differences in the ratios of gender, regular exercise, hypertension, tophus, renal insufficiency, hyperlipidemia, impaired glucose metabolism, liver dysfunction among the three groups (all P<0...
May 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28420322/epidemiology-of-paediatric-renal-stone-disease-a-22-year-single-centre-experience-in-the-uk
#10
Naomi Issler, Stephanie Dufek, Robert Kleta, Detlef Bockenhauer, Naima Smeulders, William Van't Hoff
BACKGROUND: Whilst still rare, the incidence of paediatric stone disease is increasing in developed countries and it is important to evaluate the aetiology. We set up a dedicated renal stone service for children combining medical and surgical expertise in 1993 and now have a large case series of children to investigate the epidemiology. METHODS: A retrospective hospital note review of children presenting with kidney stones during the last 22 years (1993-2015) was conducted...
April 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28417430/the-emergence-of-kidney-stone-disease-during-childhood-impact-on-adults
#11
REVIEW
Jeremy R Bonzo, Gregory E Tasian
PURPOSE OF REVIEW: The goal of this chapter is to review the recent epidemiologic trends of kidney stone disease and discuss the impact of the increasing incidence of nephrolithiasis among children on adults with respect to extra-renal manifestations, surgical management, and secondary prevention. RECENT FINDINGS: Among pediatric patients, kidney stone disease has been increasing at a rate of approximately 5-10% annually. Kidney stone disease has been associated with increased risks of coronary heart disease, chronic kidney disease, hypertension, and decreased bone mineral density, which is concerning for patients diagnosed at a young age...
June 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28405703/metabolic-syndrome-contributes-to-renal-injury-mediated-by-hyperoxaluria-in-a-murine-model-of-nephrolithiasis
#12
Javier Sáenz-Medina, E Jorge, C Corbacho, M Santos, A Sánchez, P Soblechero, E Virumbrales, E Ramil, M J Coronado, I Castillón, D Prieto, J Carballido
Metabolic syndrome (MS) individuals have a higher risk of developing chronic kidney disease through unclear pathogenic mechanisms. MS has been also related with higher nephrolithiasis prevalence. To establish the influence of MS on renal function, we designed a murine model of combined metabolic syndrome and hyperoxaluria. Four groups of male Sprague-Dawley rats were established: (1) control group (n = 10) fed with standard chow; (2) stone former group (SF) (n = 10) fed with standard chow plus 0.75% ethylene glycol administered in the drinking water; (3) metabolic syndrome group (MS) (n = 10), fed with 60% fructose diet; (4) metabolic syndrome + stone former group (MS + SF) (n = 10), 60% fructose diet and 0...
April 12, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28318298/factors-associated-with-compliance-to-increased-fluid-intake-and-urine-volume-following-dietary-counseling-in-first-time-kidney-stone-patients
#13
Aziz Khambati, Richard S Matulewicz, Kent T Perry, Robert B Nadler
OBJECTIVE: Increasing fluid intake to achieve a urine volume (UV) of >2.5 L/day decreases stone events. We assessed compliance rates and demographic and clinical variables associated with increased fluid intake and UV in patients with urolithiasis following dietary counseling. MATERIALS AND METHODS: In a retrospective study, patients with a low baseline UV (<2.5 L/day) on an initial 24-hour urine collection during metabolic stone evaluation were identified between 2010 and 2015...
June 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28301430/etiopathogenesis-of-nephrolithiasis-in-ulcerative-colitis-patients-with-the-ileal-pouch-anal-anastomosis
#14
Zubin Arora, Saurabh Mukewar, Rocio Lopez, Debra Camino, Bo Shen, Phillip Hall
BACKGROUND: Our previous study showed that nephrolithiasis is a common complication in ulcerative colitis patients after ileal pouch anal anastomosis (IPAA). However, the pathogenesis of nephrolithiasis in IPAA patients has not been studied. The aim of this study was to compare urine and serum metabolic compositions in IPAA patients with nephrolithiasis and controls with IPAA and no nephrolithiasis. METHODS: Using cross-sectional study design, serum and 24-hour urine metabolic compositions were compared between IPAA patients with nephrolithiasis (the study group) and those without (the control group)...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28298867/stones-bones-groans-thrones-and-psychiatric-overtones-systemic-associations-of-sclerochoroidal-calcification
#15
Jordan A Sugarman, Alexzandra M Douglass, Emil Anthony T Say, Carol L Shields
Sclerochoroidal calcification (SCC) is a frequent masquerader of choroidal melanoma with important systemic associations such as hyperparathyroidism and parathyroid adenoma. Herein, we describe a case of a 67-year-old male who presented with an amelanotic choroidal lesion in the right eye (OD) and a history of kidney stones. Ultrasonography showed the lesion to be flat and calcified OD. Incidentally, a subclinical calcified plaque was also found in the fellow eye. Optical coherence tomography showed an elevated suprachoroidal mass in a table mountain configuration OD and flat configuration left eye, consistent with type 4 and type 1 SCC...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28277037/fruit-extract-of-the-medicinal-plant-crataegus-oxyacantha-exerts-genotoxic-and-mutagenic-effects-in-cultured-cells
#16
Ana Paula Oliveira de Quadros, Dania Elisa Christofoletti Mazzeo, Maria Aparecida Marin-Morales, Fábio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Crataegus oxyacantha, a plant of the Rosaceae family also known "English hawthorn, haw, maybush, or whitethorn," has long been used for medicinal purposes such as digestive disorders, hyperlipidemia, dyspnea, inducing diuresis, and preventing kidney stones. However, the predominant use of this plant has been to treat cardiovascular disorders. Due to a lack of studies on the genotoxicity of C. oxyacantha, this investigation was undertaken to determine whether its fruit extract exerts cytotoxic, genotoxic, or clastogenic/aneugenic effects in leukocytes and HepG2 (liver hepatocellular carcinoma) cultured human cells, or mutagenic effects in TA100 and TA98 strains of Salmonella typhimurium bacterium...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28275812/urinary-stone-disease-in-pediatric-and-adult-metabolic-bone-clinic-patients
#17
Andrew L Schwaderer, Abimbola Oduguwa, Kirsten Kusumi
Kidney stones are increasing in the pediatric and adult populations; similarly osteoporosis is increasingly recognized in children. While kidney stone formers are known to suffer from low bone density, metabolic bone patients have not been considered a high risk population for kidney stones. Retrospective chart review of Nationwide Children's Hospital Metabolic Bone Clinic patients from October 2009-2013. Patients were identified by ICD 9 codes for osteoporosis, osteopenia, low bone density and kidney stones...
March 8, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28247719/-cystine-as-a-risk-factor-of-the-stone-formation-in-kidney-the-reference-value-range-of-urinary-excretion-the-stage-diagnosis-of-cystine-metabolism-disorder
#18
A A Gres, D M Nitkin, T M Juraha, A A Sivakow
OBJECTIVE: to define the reference value ranges of cystine, lysine and arginine urinary excretion relative to creatinine in the morning urine samples for the metabolic disorders diagnosis leading to the formation of urinary stones. MATERIALS AND METHODS: the study involved 695 healthy individuals aged 1-17 and 1564 patients with urolithiasis aged 7-45. The content of cystine in the urine samples was determined by high performance liquid chromatography. The chemical composition of urinary stones was investigated by methods of the qualitative chemical reaction and the crystals microscopy...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28221140/-urinary-lithiasis-as-a-systemic-disease
#19
Mercedes Leanez Jiménez, Fernando Candau Vargas-Zúñiga, Carlos Reina Ruiz
Urinary lithiasis is a prevalent disorder of uncertain origin which provokes health problems through potential harm to the urinary system, renal parenchyma or the body as a whole, with a frequent trend to relapse. Historically urinary calculi have been studied and treated as an isolated disease but nowadays we know more about their connection with other pathological entities. In a small percentage of patients, diseases like primary hyperparathyroidism, tubular renal acidosis, inflammatory bowel disease or bariatric surgery have a fairly well studied physiopathological link with kidney stones...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28217698/questions-and-challenges-associated-with-studying-the-microbiome-of-the-urinary-tract
#20
REVIEW
Yige Bao, Kait F Al, Ryan M Chanyi, Samantha Whiteside, Malcom Dewar, Hassan Razvi, Gregor Reid, Jeremy P Burton
Urologists are typically faced with clinical situations for which the microbiome may have been a contributing factor. Clinicians have a good understanding regarding the role of bacteria related to issues such as antibiotic resistance; however, they generally have a limited grasp of how the microbiome may relate to urological issues. The largest part of the human microbiome is situated in the gastrointestinal tract, and though this is mostly separated from the urinary system, bacterial dissemination and metabolic output by this community is thought to have a significant influence on urological conditions...
January 2017: Annals of Translational Medicine
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