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Relaxometry

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https://www.readbyqxmd.com/read/28808201/thalamic-paramagnetic-iron-by-t2-relaxometry-correlates-with-severity-of-multiple-sclerosis
#1
Eva Baranovicova, Ema Kantorova, Dagmar Kalenska, Lucia Lichardusova, Michal Bittsan-Sky, Dusan Dobrota
Iron can contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain. We focus on the thalamus as an information transmitter between various subcortical and cortical areas. Thalamic iron seems to follow different rules than iron in other deep gray matter structures and its relation to the clinical outcomes of MS is still indistinct. In our study, we investigated a connection between thalamic iron and patients' disability and course of the disease. The presence of paramagnetic substances in the tissues was tracked by T2* quantification...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28790121/cardiovascular-magnetic-resonance-relaxometry-predicts-regional-functional-outcome-after-experimental-myocardial-infarction
#2
Sebastian M Haberkorn, Christoph Jacoby, Zhaoping Ding, Petra Keul, Florian Bönner, Amin Polzin, Bodo Levkau, Jürgen Schrader, Malte Kelm, Ulrich Flögel
BACKGROUND: Cardiovascular magnetic resonance with gadolinium-based contrast agents has established as gold standard for tissue characterization after myocardial infarction (MI). Beyond accurate diagnosis, the value of cardiovascular magnetic resonance to predict the outcome after MI has yet to be substantiated. METHODS AND RESULTS: Recent cardiovascular magnetic resonance approaches were systematically compared for quantification of tissue injury and functional impairment after MI using murine models with permanent left anterior descending coronary artery ligation (n=14) or 50 minutes ischemia/reperfusion (n=13)...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28775058/analysis-of-white-matter-damage-in-patients-with-multiple-sclerosis-via-a-novel-in-vivo-mr-method-for-measuring-myelin-axons-and-g-ratio
#3
A Hagiwara, M Hori, K Yokoyama, M Nakazawa, R Ueda, M Horita, C Andica, O Abe, S Aoki
BACKGROUND AND PURPOSE: Myelin and axon volume fractions can now be estimated via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer diameter of a nerve fiber. The purpose of this study was to evaluate WM damage in patients with MS via this novel MR imaging technique. MATERIALS AND METHODS: Twenty patients with relapsing-remitting MS with a combined total of 149 chronic plaques were analyzed. Myelin volume fraction was calculated based on simultaneous tissue relaxometry...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28764065/the-use-of-two-dimensional-nmr-relaxometry-in-bread-staling-a-valuable-tool
#4
E Curti, E Carini, M F Cobo, T Bocher, E Vittadini
Staling of bread was investigated in terms of physico-chemical parameters and one (1D) and two dimensional (2D) (1)H Nuclear Magnetic Resonance (NMR) relaxometry. Physico-chemical properties were consistent with those generally reported for bread staling (crumb moisture loss, decrease in frozen water content, formation of amylopectin crystals, crumb hardening). One dimensional (1)H NMR investigation suggested the presence of only one T1 protons population, while T2 was representative of multiple proton populations, that well related to the observed physico-chemical changes...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28762536/a-novel-mr-based-method-for-detection-of-cartilage-delamination-in-femoroacetabular-impingement-patients
#5
Michael A Samaan, Valentina Pedoia, Alan L Zhang, Matthew C Gallo, Thomas M Link, Richard B Souza, Sharmila Majumdar
In this study, quantitative magnetic resonance based measurements were used to evaluate T1ρ and T2 mapping and heterogeneity in femoroacetabular impingement (FAI) patients with acetabular cartilage delamination and to determine the ability of these quantitative MR-based measurements in detecting delamination. Unilateral hip joint MR-scans of 36 FAI patients with arthroscopically-confirmed acetabular cartilage delamination and 36 age, gender and BMI matched controls were obtained. T1ρ and T2 mapping and heterogeneity of the hip joint articular cartilage were assessed in both groups using voxel-based relaxometry (VBR)...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28759741/correction-of-environmental-magnetic-fields-for-the-acquisition-of-nuclear-magnetic-relaxation-dispersion-profiles-below-earth-s-field
#6
Vasileios Zampetoulas, David J Lurie, Lionel M Broche
T1 relaxation times can be measured at a range of magnetic field strengths by Fast Field-Cycling (FFC) NMR relaxometry to provide T1-dispersion curves. These are valuable tools for the investigation of material properties as they provide information about molecular dynamics non-invasively. However, accessing information at fields below 230 μT (10kHz proton Larmor frequency) requires careful correction of unwanted environmental magnetic fields. In this work a novel method is proposed that compensates for the environmental fields on a FFC-NMR relaxometer and extends the acquisition of Nuclear Magnetic Relaxation Dispersion profiles to 2...
July 22, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28741075/brain-relaxometry-after-macrocyclic-gd-based-contrast-agent
#7
Andreas Müller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Elke Hattingen
PURPOSE: To assess if ratios of T1-weighted (T1w) signal intensity (SI) and quantitative T1 relaxometry (qT1) change on serial administration of macrocyclic gadobutrol. METHODS: A total of 17 glioblastoma patients were scanned at 3.0 T magnetic resonance imaging (MRI) every 6 weeks after tumor resection with standard MRI and T1 and T2 relaxometry before and after gadobutrol administration. On co-registered images T1w SI was measured and relaxation times T1 (qT1) and quantitative T2 (qT2) were quantified in several deep grey matter nuclei as ratios relative to frontal white matter and to the pons...
July 24, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28703417/dynamic-nuclear-polarization-fast-field-cycling-method-for-selective-study-of-molecular-dynamics-in-block-copolymers
#8
Bulat Gizatullin, Oliver Neudert, Siegfried Stapf, Carlos Mattea
Dynamic nuclear polarization (DNP) is one of the most useful methods for increasing sensitivity in NMR. It is based on the transfer of magnetization from an electron to the nuclear spin system. Based on previous work demonstrating the feasibility of integrating DNP with Fast Field Cycling (FFC) relaxometry, and the possibility to distinguish between different mechanisms such as Overhauser Effect (OE) and Solid Effect (SE), the first FFC study of the differential relaxation properties of a copolymer is presented...
July 13, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28699215/automated-t2-relaxometry-of-the-hippocampus-for-temporal-lobe-epilepsy
#9
Gavin P Winston, Sjoerd B Vos, Jane L Burdett, M Jorge Cardoso, Sebastien Ourselin, John S Duncan
OBJECTIVE: Hippocampal sclerosis (HS), the most common cause of refractory temporal lobe epilepsy, is associated with hippocampal volume loss and increased T2 signal. These can be identified on quantitative imaging with hippocampal volumetry and T2 relaxometry. Although hippocampal segmentation for volumetry has been automated, T2 relaxometry currently involves subjective and time-consuming manual delineation of regions of interest. In this work, we develop and validate an automated technique for hippocampal T2 relaxometry...
July 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28697447/dynamical-regimes-of-lipids-in-additivated-liposomes-with-enhanced-elasticity-a-field-cycling-nmr-relaxometry-approach
#10
Carla C Fraenza, Esteban Anoardo
We study the molecular dynamics of lipids in binary large unilamellar liposomes suspended in D2O composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or soy phosphatidylcholine (SPC) additivated with different percentiles of sodium deoxycholate (SDC). We use the fast field-cycling proton NMR relaxometry technique over a wide timescale and at diverse temperatures. A model previously validated in different formulations is here employed for the relaxometric analysis of elastic vesicles. A new dynamical regime is observed for the first time in additivated DMPC and additivated/non-additivated SPC liposomes...
September 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28692849/designing-healthier-comminuted-meat-products-effect-of-dietary-fibers-on-water-distribution-and-texture-of-a-fat-reduced-meat-model-system
#11
Minyi Han, Hanne Christine Bertram
Development of healthier meat products is needed to meet consumers' request. The effects of dietary fiber addition on the water distribution, water binding capacity (WBC), and textural properties of a fat-reduced model meat system enriched with inulin, cellulose, carboxymethyl cellulose (CMC), chitosan, pectin, respectively, were investigated in this study. The fibers were incorporated in powder form to constitute 2% (w/w) of the meat batter. In general, fiber enrichment resulted in significant lower cooking loss and improved WBC, while the impact on texture was dependent on the specific dietary fiber...
July 3, 2017: Meat Science
https://www.readbyqxmd.com/read/28688198/study-of-the-interactions-between-proximal-femur-3d-bone-shape-cartilage-health-and-biomechanics-in-patients-with-hip-osteoarthritis
#12
Valentina Pedoia, Michael A Samaan, Gaurav Inamdar, Matthew C Gallo, Richard B Souza, Sharmila Majumdar
In this study quantitative MRI and gait analysis were used to investigate the relationships between proximal femur 3D bone shape, cartilage morphology, cartilage biochemical composition, and joint biomechanics in subject with hip Osteoarthritis (OA). Eighty subjects underwent unilateral hip MR-imaging: T1ρ and T2 relaxation times were extracted through voxel based relaxometry and bone shape was assessed with 3D MRI-based statistical shape modeling. In addition, 3D gait analysis was performed in seventy-six of the studied subjects...
July 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28687012/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#13
Elke Hattingen, Andreas Müeller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28684589/imaging-in-metabolic-research-adipose-tissue-and-liver
#14
Jesper Lundbom
Adipose tissue and liver are central tissues in whole body energy metabolism. Their composition, structure and function can be non-invasively imaged using a variety of measurement techniques, which provide a safe alternative to an invasive biopsy. Imaging of adipose tissue is focused on quantitating the distribution of adipose tissue in subcutaneous and intra-abdominal (visceral) adipose tissue depots. Also detailed subdivisions of adipose tissue can be distinguished with modern imaging techniques. Adipose tissue accumulation or infiltration of other organs can also be imaged...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28674518/brain-susceptibility-changes-in-a-patient-with-natalizumab-related-progressive-multifocal-leukoencephalopathy-a-longitudinal-quantitative-susceptibility-mapping-and-relaxometry-study
#15
Giuseppe Pontillo, Sirio Cocozza, Roberta Lanzillo, Pasquale Borrelli, Anna De Rosa, Vincenzo Brescia Morra, Enrico Tedeschi, Giuseppe Palma
BACKGROUND: Brain MRI plays an essential role in both diagnosis and follow-up of the JC virus infection of the brain. Recently, MR studies with susceptibility-weighted imaging (SWI) sequences have shown hypointensities in U-fibers adjacent to white matter (WM) lesions of progressive multifocal leukoencephalopathy (PML). This finding has been confirmed with the use of quantitative susceptibility mapping (QSM), allowing to hypothesize a paramagnetic effect in these regions. Here, we report the first longitudinal assessment of QSM and R2* maps in natalizumab-associated PML to evaluate serial changes in susceptibility contrast images and their role in PML diagnosis and follow-up...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28638673/monitoring-of-cellular-changes-in-the-bone-marrow-following-pth-1-34-treatment-of-ovx-rats-using-a-portable-stray-field-nmr-scanner
#16
Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo
Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. Objectives. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28636349/water-dynamics-from-the-surface-to-the-interior-of-a-supramolecular-nanostructure
#17
Julia H Ortony, Baofu Qiao, Christina J Newcomb, Timothy J Keller, Liam C Palmer, Elad Deiss-Yehiely, Monica Olvera de la Cruz, Songi Han, Samuel I Stupp
Water within and surrounding the structure of a biological system adopts context-specific dynamics that mediate virtually all of the events involved in the inner workings of a cell. These events range from protein folding and molecular recognition to the formation of hierarchical structures. Water dynamics are mediated by the chemistry and geometry of interfaces where water and biomolecules meet. Here we investigate experimentally and computationally the translational dynamics of vicinal water molecules within the volume of a supramolecular peptide nanofiber measuring 6...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28624093/osmotic-dehydration-of-organic-kiwifruit-pre-treated-by-pulsed-electric-fields-and-monitored-by-nmr
#18
Maria Victoria Traffano-Schiffo, Luca Laghi, Marta Castro-Giraldez, Urszula Tylewicz, Pietro Rocculi, Luigi Ragni, Marco Dalla Rosa, Pedro J Fito
Osmotic dehydration (OD) is a widely used preservation technique that consists in the reduction in food water activity by the immersion of the biological tissue in hypertonic solutions. The aim of this work was to analyze the effect of pulsed electric fields (PEF) in mass transfer as a pre-treatment of the OD using NMR. In this sense, PEF pre-treatments were done using three different voltages (100, 250 and 400V/cm) and 60 number of pulse. The OD of kiwifruit was carried out in 61.5% of sucrose solution at 25°C, for a contact period from 0 to 120min...
December 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28624092/study-on-the-effects-of-wheat-bran-incorporation-on-water-mobility-and-biopolymer-behavior-during-bread-making-and-storage-using-time-domain-1-h-nmr-relaxometry
#19
S Hemdane, P J Jacobs, G M Bosmans, J Verspreet, J A Delcour, C M Courtin
Water binding is suggested to be key in the deleterious effect of wheat bran on bread quality. This study investigates water mobility and biopolymer behavior during bran-rich bread making and storage, using (1)H NMR. Coarse, ground, and pericarp-enriched bran were incorporated in bread dough, and their impact on freshly baked and stored bread properties was assessed. Compared to wheat flour control dough, bran incorporation resulted in a progressive immobilization of water during dough resting, which could be linked to changes in evolution of dough height during fermentation and oven rise...
December 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28624091/study-of-biopolymer-mobility-and-water-dynamics-in-wheat-bran-using-time-domain-1-h-nmr-relaxometry
#20
S Hemdane, P J Jacobs, G M Bosmans, J Verspreet, J A Delcour, C M Courtin
In this study, the molecular mobility of water and biopolymers in coarse, ground, and pericarp-enriched (PE) wheat bran and refined flour was investigated using time-domain proton nuclear magnetic resonance relaxometry, and related to their hydration properties. Several specific proton populations were present in the bran samples but not in flour. These populations were mainly assigned to protons of bran-related compounds such as arabinoxylan, cellulose, and lipids. All bran samples showed similar proton distributions at a 44% moisture level, although the chemical composition of coarse/ground bran and PE bran differed...
December 1, 2017: Food Chemistry
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