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Joseph M Lane

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https://www.readbyqxmd.com/read/28262568/a-bleeding-assessment-tool-correlates-with-intraoperative-blood-loss-in-children-and-adolescents-undergoing-major-spinal-surgery
#1
Jennifer M Anadio, Peter F Sturm, Johan M Forslund, Sunil Agarwal, Adam Lane, Cristina Tarango, Joseph S Palumbo
Screening laboratory studies for bleeding disorders are of little predictive value for operative bleeding risk in adults. Predicting perioperative bleeding in pediatric patients is particularly difficult as younger patients often have not had significant hemostatic challenges. This issue is distinctly important for high bleeding risk surgeries, such as major spinal procedures. The aim of this study was to determine if the score of a detailed bleeding questionnaire (BQ) correlated with surgical bleeding in pediatric patients undergoing major spinal surgery...
February 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28241211/families-as-partners-in-hospital-error-and-adverse-event-surveillance
#2
Alisa Khan, Maitreya Coffey, Katherine P Litterer, Jennifer D Baird, Stephannie L Furtak, Briana M Garcia, Michele A Ashland, Sharon Calaman, Nicholas C Kuzma, Jennifer K O'Toole, Aarti Patel, Glenn Rosenbluth, Lauren A Destino, Jennifer L Everhart, Brian P Good, Jennifer H Hepps, Anuj K Dalal, Stuart R Lipsitz, Catherine S Yoon, Katherine R Zigmont, Rajendu Srivastava, Amy J Starmer, Theodore C Sectish, Nancy D Spector, Daniel C West, Christopher P Landrigan, Brenda K Allair, Claire Alminde, Wilma Alvarado-Little, Marisa Atsatt, Megan E Aylor, James F Bale, Dorene Balmer, Kevin T Barton, Carolyn Beck, Zia Bismilla, Rebecca L Blankenberg, Debra Chandler, Amanda Choudhary, Eileen Christensen, Sally Coghlan-McDonald, F Sessions Cole, Elizabeth Corless, Sharon Cray, Roxi Da Silva, Devesh Dahale, Benard Dreyer, Amanda S Growdon, LeAnn Gubler, Amy Guiot, Roben Harris, Helen Haskell, Irene Kocolas, Elizabeth Kruvand, Michele Marie Lane, Kathleen Langrish, Christy J W Ledford, Kheyandra Lewis, Joseph O Lopreiato, Christopher G Maloney, Amanda Mangan, Peggy Markle, Fernando Mendoza, Dale Ann Micalizzi, Vineeta Mittal, Maria Obermeyer, Katherine A O'Donnell, Mary Ottolini, Shilpa J Patel, Rita Pickler, Jayne Elizabeth Rogers, Lee M Sanders, Kimberly Sauder, Samir S Shah, Meesha Sharma, Arabella Simpkin, Anupama Subramony, E Douglas Thompson, Laura Trueman, Tanner Trujillo, Michael P Turmelle, Cindy Warnick, Chelsea Welch, Andrew J White, Matthew F Wien, Ariel S Winn, Stephanie Wintch, Michael Wolf, H Shonna Yin, Clifton E Yu
Importance: Medical errors and adverse events (AEs) are common among hospitalized children. While clinician reports are the foundation of operational hospital safety surveillance and a key component of multifaceted research surveillance, patient and family reports are not routinely gathered. We hypothesized that a novel family-reporting mechanism would improve incident detection. Objective: To compare error and AE rates (1) gathered systematically with vs without family reporting, (2) reported by families vs clinicians, and (3) reported by families vs hospital incident reports...
February 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27871088/structure-of-photosystem-ii-and-substrate-binding-at-room-temperature
#3
Iris D Young, Mohamed Ibrahim, Ruchira Chatterjee, Sheraz Gul, Franklin D Fuller, Sergey Koroidov, Aaron S Brewster, Rosalie Tran, Roberto Alonso-Mori, Thomas Kroll, Tara Michels-Clark, Hartawan Laksmono, Raymond G Sierra, Claudiu A Stan, Rana Hussein, Miao Zhang, Lacey Douthit, Markus Kubin, Casper de Lichtenberg, Long Vo Pham, Håkan Nilsson, Mun Hon Cheah, Dmitriy Shevela, Claudio Saracini, Mackenzie A Bean, Ina Seuffert, Dimosthenis Sokaras, Tsu-Chien Weng, Ernest Pastor, Clemens Weninger, Thomas Fransson, Louise Lassalle, Philipp Bräuer, Pierre Aller, Peter T Docker, Babak Andi, Allen M Orville, James M Glownia, Silke Nelson, Marcin Sikorski, Diling Zhu, Mark S Hunter, Thomas J Lane, Andy Aquila, Jason E Koglin, Joseph Robinson, Mengning Liang, Sébastien Boutet, Artem Y Lyubimov, Monarin Uervirojnangkoorn, Nigel W Moriarty, Dorothee Liebschner, Pavel V Afonine, David G Waterman, Gwyndaf Evans, Philippe Wernet, Holger Dobbek, William I Weis, Axel T Brunger, Petrus H Zwart, Paul D Adams, Athina Zouni, Johannes Messinger, Uwe Bergmann, Nicholas K Sauter, Jan Kern, Vittal K Yachandra, Junko Yano
Light-induced oxidation of water by photosystem II (PS II) in plants, algae and cyanobacteria has generated most of the dioxygen in the atmosphere. PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). Under illumination, the OEC cycles through five intermediate S-states (S0 to S4), in which S1 is the dark-stable state and S3 is the last semi-stable state before O-O bond formation and O2 evolution...
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27741156/the-role-of-oligosaccharides-in-host-microbial-interactions-for-human-health
#4
Sarah A Ross, Jonathan A Lane, Mariarosaria Marotta, Devon Kavanaugh, Joseph Thomas Ryan, Lokesh Joshi, Rita M Hickey
Milk oligosaccharides have many associated bioactivities which can contribute to human health and offer protective properties to the host. Such bioactivities include anti-infective properties whereby oligosaccharides interact with bacterial cells and prevent adhesion to the host and subsequent colonization. Milk oligosaccharides have also been shown to alter the glycosylation of intestinal cells, leading to a reduction in pathogenic colonization. In addition, these sugars promote adhesion of commensal bacterial strains to host cells as well as possessing the ability to alter mucin expression in intestinal cells and improve barrier function...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27711844/femtosecond-photodissociation-dynamics-of-1-4-diiodobenzene-by-gas-phase-x-ray-scattering-and-photoelectron-spectroscopy
#5
Brian Stankus, James M Budarz, Adam Kirrander, David Rogers, Joseph Robinson, Thomas J Lane, Daniel Ratner, Jerome Hastings, Michael P Minitti, Peter M Weber
We present a multifaceted investigation into the initial photodissociation dynamics of 1,4-diiodobenzene (DIB) following absorption of 267 nm radiation. We combine ultrafast time-resolved photoelectron spectroscopy and X-ray scattering experiments performed at the Linac Coherent Light Source (LCLS) to study the initial electronic excitation and subsequent rotational alignment, and interpret the experiments in light of Complete Active Space Self-Consistent Field (CASSCF) calculations of the excited electronic landscape...
December 16, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27703421/treatment-of-pre-collapse-stages-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-randomized-control-trials
#6
REVIEW
Jordan C Villa, Solomon Husain, Jelle P van der List, Arianna Gianakos, Joseph M Lane
BACKGROUND: Treatment for osteonecrosis of the femoral head (ONFH) remains controversial. Current reviews include low-level evidence studies evaluating the treatment of both pre-collapse and collapse stages of the disease. QUESTIONS/PURPOSES: The purpose of the current study is to systematically review the literature evaluating core decompression (CD) with bone marrow mesenchymal cells (BMMCs), CD alone, and bisphosphonate treatment in pre-collapse ONFH by focusing just on randomized clinical trials (RCTs) reporting functional and radiologic outcomes...
October 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27701076/laboratory-evolution-of-artificially-expanded-dna-gives-redesignable-aptamers-that-target-the-toxic-form-of-anthrax-protective-antigen
#7
Elisa Biondi, Joshua D Lane, Debasis Das, Saurja Dasgupta, Joseph A Piccirilli, Shuichi Hoshika, Kevin M Bradley, Bryan A Krantz, Steven A Benner
Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has been outlined and the first to inhibit biologically important activities of its target, the protective antigen from Bacillus anthracis We show how rational design based on secondary structure predictions can also direct the use of AEGIS to improve the stability and binding of the aptamer to its target...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27532490/benzene-probes-in-molecular-dynamics-simulations-reveal-novel-binding-sites-for-ligand-design
#8
Yaw Sing Tan, Judith Reeks, Christopher J Brown, Dawn Thean, Fernando Jose Ferrer Gago, Tsz Ying Yuen, Eunice Tze Leng Goh, Xue Er Cheryl Lee, Claire E Jennings, Thomas L Joseph, Rajamani Lakshminarayanan, David P Lane, Martin E M Noble, Chandra S Verma
Protein flexibility poses a major challenge in binding site identification. Several computational pocket detection methods that utilize small-molecule probes in molecular dynamics (MD) simulations have been developed to address this issue. Although they have proven hugely successful at reproducing experimental structural data, their ability to predict new binding sites that are yet to be identified and characterized has not been demonstrated. Here, we report the use of benzenes as probe molecules in ligand-mapping MD (LMMD) simulations to predict the existence of two novel binding sites on the surface of the oncoprotein MDM2...
September 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27385942/the-efficacy-of-bisphosphonates-with-core-decompression-and-mesenchymal-stem-cells-compared-with-bisphosphonates-alone-in-the-treatment-of-osteonecrosis-of-the-hip-a-retrospective-study
#9
Arianna L Gianakos, Joaquin Moya-Angeler, Shivi Duggal, Lester Zambrana, Kara G Fields, Douglas N Mintz, Charles N Cornell, Joseph M Lane
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) is a devastating disease with complete collapse of the femoral head often reported in greater than 70% of patients within 3 to 4 years of diagnosis. Early intervention prior to collapse may improve the chance of success of joint preserving procedures. QUESTIONS/PURPOSES: The purpose of this study was to evaluate whether core decompression with mesenchymal stem cells combined with bisphosphonate therapy can improve the clinical outcomes and reduce the risk of hip replacement when compared to treatment with bisphosphonate therapy alone...
July 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27379708/a-phase-2-study-of-the-hsp90-inhibitor-auy922-as-treatment-for-patients-with-refractory-gastrointestinal-stromal-tumors
#10
MULTICENTER STUDY
Johanna C Bendell, Todd M Bauer, Ruth Lamar, Mathew Joseph, William Penley, Dana S Thompson, David R Spigel, Rami Owera, Cassie M Lane, Chris Earwood, Howard A Burris
BACKGROUND: AUY922 is an inhibitor of heat shock protein 90 (Hsp90). Hsp90 inhibitors induce kit degradation in preclinical gastrointestinal stromal tumor (GIST) models. This trial was designed to determine the progression-free survival (PFS) of patients with GIST refractory to or intolerant of imatinib and sunitinib. METHODS: Eligible patients received AUY922 70 mg/mg(2) by intravenous (IV) infusion on days 1, 8, and 15 of 21-day cycles. Treatment continued until progression or unacceptable toxicity...
July 2, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27353212/enhancing-the-effectiveness-of-biological-control-programs-of-invasive-species-through-a-more-comprehensive-pest-management-approach
#11
Joseph M DiTomaso, Robert A Van Steenwyk, Robert M Nowierski, Jennifer L Vollmer, Eric Lane, Earl Chilton, Patrick L Burch, Phil E Cowan, Kenneth Zimmerman, Christopher P Dionigi
Invasive species are one of the greatest economic and ecological threats to agriculture and natural areas in the US and the world. Among the available management tools, biological control provides one of the most economical and long-term effective strategies for managing widespread and damaging invasive species populations of nearly all taxa. However, integrating biological control programs in a more complete integrated pest management approach that utilizes increased information and communication, post-release monitoring, adaptive management practices, long-term stewardship strategies, and new and innovative ecological and genetic technologies can greatly improve the effectiveness of biological control...
January 2017: Pest Management Science
https://www.readbyqxmd.com/read/27239197/coffee-consumption-and-the-incidence-of-colorectal-cancer-in-women
#12
Erik J Groessl, Matthew A Allison, Joseph C Larson, Samuel B Ho, Linda G Snetslaar, Dorothy S Lane, Katie M Tharp, Marcia L Stefanick
Background. Higher coffee consumption has been associated with decreased incidence of colorectal cancer. Our objective was to examine the relationship of coffee intake to colorectal cancer incidence in a large observational cohort of postmenopausal US women. Methods. Data were collected for the Women's Health Initiative Observational Study providing a follow-up period of 12.9 years. The mean age of our sample (N = 83,778 women) was 63.5 years. Daily coffee intake was grouped into 3 categories: None, moderate (>0-<4 cups), and high (4+ cups)...
2016: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/27194496/racial-and-socioeconomic-disparities-in-hip-fracture-care
#13
Christopher J Dy, Joseph M Lane, Ting Jung Pan, Michael L Parks, Stephen Lyman
BACKGROUND: Despite declines in both the incidence of and mortality following hip fracture, there are racial and socioeconomic disparities in treatment access and outcomes. We evaluated the presence and implications of disparities in delivery of care, hypothesizing that race and community socioeconomic characteristics would influence quality of care for patients with a hip fracture. METHODS: We collected data from the New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS), which prospectively captures information on all discharges from nonfederal acute-care hospitals in New York State...
May 18, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27189150/using-hounsfield-units-to-assess-osteoporotic-status-on-wrist-computed-tomography-scans-comparison-with-dual-energy-x-ray-absorptiometry
#14
Christine C Johnson, Elizabeth B Gausden, Andrew J Weiland, Joseph M Lane, Joseph J Schreiber
PURPOSE: Rates of evaluation and treatment for osteoporosis following distal radius fragility fractures remain low. As a subset of patients with these fractures undergo diagnostic computed tomography (CT) scan of the wrist, utilizing bone mineral density (BMD) measurements available with this imaging can be used to detect osteopenia or osteoporosis. This information may consequently prompt intervention to prevent a subsequent fracture. The purpose of this study was to determine if Hounsfield unit (HU) measurements at the wrist correlate with BMD measurements of the hip, femoral neck, and lumbar spine and to assess the ability of these HU measurements to detect osteoporosis of the hip...
July 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27154530/the-frank-stinchfield-award-total-hip-arthroplasty-for-femoral-neck-fracture-is-not-a-typical-drg-470-a-propensity-matched-cohort-study
#15
COMPARATIVE STUDY
William W Schairer, Joseph M Lane, David A Halsey, Richard Iorio, Douglas E Padgett, Alexander S McLawhorn
BACKGROUND: Hip fractures are a major public health concern. For displaced femoral neck fractures, the needs for medical services during hospitalization and extending beyond hospital discharge after total hip arthroplasty (THA) may be different than the needs after THA performed for osteoarthritis (OA), yet these differences are largely uncharacterized, and the Medicare Severity Diagnosis-Related Groups system does not distinguish between THA performed for fracture and OA. QUESTIONS/PURPOSES: (1) What are the differences in in-hospital and 30-day postoperative clinical outcomes for THA performed for femoral neck fracture versus OA? (2) Is a patient's fracture status, that is whether or not a patient has a femoral neck fracture, associated with differences in in-hospital and 30-day postoperative clinical outcomes after THA? METHODS: The National Surgical Quality Improvement Program (NSQIP) database, which contains outcomes for surgical patients up to 30 days after discharge, was used to identify patients undergoing THA for OA and femoral neck fracture...
February 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27050653/craniocervical-pneumatization-estimation-of-prevalence-and-imaging-of-treatment-response
#16
Courtney M Tomblinson, Nicholas L Deep, Steven M Weindling, John I Lane, Linsey S Scheibler, David M Barrs, Joseph M Hoxworth
OBJECTIVE: Estimate the prevalence of craniocervical pneumatization (CCP) and describe successful treatment of this condition with clinical and radiologic correlation. PATIENTS: Individuals with documented CCP on computed tomography (CT). INTERVENTION(S): CT scans of the head, temporal bone, face, neck, and cervical spine. Cessation of habitual Valsalva maneuver (VM) and insertion of pressure-equalization (PE) tubes. MAIN OUTCOME MEASURE: The prevalence of CCP on CT examinations performed during two decades in a large academic healthcare system...
July 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/26983553/structure-and-abundance-of-nitrous-oxide-complexes-in-earth-s-atmosphere
#17
Steven R Salmon, Katrina M de Lange, Joseph R Lane
We have investigated the lowest energy structures and binding energies of a series of atmospherically relevant nitrous oxide (N2O) complexes using explicitly correlated coupled cluster theory. Specifically, we have considered complexes with nitrogen (N2-N2O), oxygen (O2-N2O), argon (Ar-N2O), and water (H2O-N2O). We have calculated rotational constants and harmonic vibrational frequencies for the complexes and the constituent monomers. Statistical mechanics was used to determine the thermodynamic parameters for complex formation as a function of temperature and pressure...
April 7, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/26929850/factors-associated-with-early-functional-outcome-after-hip-fracture-surgery
#18
Matthew R Cohn, Guang-Ting Cong, Benedict U Nwachukwu, Minda L Patt, Pingal Desai, Lester Zambrana, Joseph M Lane
BACKGROUND: Hip fractures are common in the elderly and are likely to become more prevalent as the US population ages. Early functional status is an indicator of longer term outcome, yet in-hospital predictors of functional recovery, particularly time of surgery and composition of support staff, after hip fracture surgery have not been well studied. METHODS: Ninety-nine consecutive patients underwent hip fracture surgery by a single surgeon between 2009 and 2013...
March 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/26913512/variation-in-resource-utilization-for-patients-with-hip-and-pelvic-fractures-despite-equal-medicare-reimbursement
#19
COMPARATIVE STUDY
Andre M Samuel, Matthew L Webb, Adam M Lukasiewicz, Bryce A Basques, Daniel D Bohl, Arya G Varthi, Joseph M Lane, Jonathan N Grauer
BACKGROUND: Medicare currently reimburses hospitals for inpatient admissions with "bundled" payments based on patient Diagnosis-related Groups (DRGs) regardless of true hospital costs. At present, DRG 536 (fractures of the hip and pelvis) includes a broad spectrum of patients with orthopaedic trauma, likely with varying inpatient resource utilization. With the growing incidence of fractures in the elderly, inadequate reimbursements from Medicare for certain patients with DRG 536 may lead to growing financial strain on healthcare institutions caring for these patients with higher costs...
June 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26889651/international-consensus-statement-on-allergy-and-rhinology-rhinosinusitis
#20
REVIEW
Richard R Orlandi, Todd T Kingdom, Peter H Hwang, Timothy L Smith, Jeremiah A Alt, Fuad M Baroody, Pete S Batra, Manuel Bernal-Sprekelsen, Neil Bhattacharyya, Rakesh K Chandra, Alexander Chiu, Martin J Citardi, Noam A Cohen, John DelGaudio, Martin Desrosiers, Hun-Jong Dhong, Richard Douglas, Berrylin Ferguson, Wytske J Fokkens, Christos Georgalas, Andrew Goldberg, Jan Gosepath, Daniel L Hamilos, Joseph K Han, Richard Harvey, Peter Hellings, Claire Hopkins, Roger Jankowski, Amin R Javer, Robert Kern, Stilianos Kountakis, Marek L Kowalski, Andrew Lane, Donald C Lanza, Richard Lebowitz, Heung-Man Lee, Sandra Y Lin, Valerie Lund, Amber Luong, Wolf Mann, Bradley F Marple, Kevin C McMains, Ralph Metson, Robert Naclerio, Jayakar V Nayak, Nobuyoshi Otori, James N Palmer, Sanjay R Parikh, Desiderio Passali, Anju Peters, Jay Piccirillo, David M Poetker, Alkis J Psaltis, Hassan H Ramadan, Vijay R Ramakrishnan, Herbert Riechelmann, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J Schlosser, Brent A Senior, Raj Sindwani, James A Stankiewicz, Michael Stewart, Bruce K Tan, Elina Toskala, Richard Voegels, De Yun Wang, Erik K Weitzel, Sarah Wise, Bradford A Woodworth, Peter-John Wormald, Erin D Wright, Bing Zhou, David W Kennedy
BACKGROUND: The body of knowledge regarding rhinosinusitis(RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). METHODS: Evidence-based reviews with recommendations(EBRRs) were developed for scores of topics, using previously reported methodology...
February 2016: International Forum of Allergy & Rhinology
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