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JOURNAL ARTICLE
Maximilian T Löffler, Chotigar Ngarmsrikam, Paula Giesler, Gabby B Joseph, Zehra Akkaya, John A Lynch, Nancy E Lane, Michael Nevitt, Charles E McCulloch, Thomas M Link
BACKGROUND: Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression...
April 17, 2024: BMC Musculoskeletal Disorders
#2
JOURNAL ARTICLE
Jessica A Palakshappa, Jane A E Batt, Sue C Bodine, Bronwen A Connolly, Jason Doles, Jason R Falvey, Lauren E Ferrante, D Clark Files, Michael O Harhay, Kirsten Harrell, Joseph A Hippensteel, Theodore J Iwashyna, James C Jackson, Meghan B Lane-Fall, Michelle Monje, Marc Moss, Dale M Needham, Matthew W Semler, Shouri Lahiri, Lars Larsson, Carla M Sevin, Tarek Sharshar, Benjamin Singer, Troy Stevens, Stephanie P Taylor, Christian R Gomez, Guofei Zhou, Timothy D Girard, Catherine L Hough
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproven. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation...
March 13, 2024: American Journal of Respiratory and Critical Care Medicine
#3
JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
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JOURNAL ARTICLE
Justin L Makovicka, Joseph C Brinkman, Nathan Benner, Aiden J Tokish, M Lane Moore, John M Tokish
Biceps tenodesis has been proven to be an effective treatment for biceps tendon and superior labral pathology. Many techniques including both open and arthroscopic approaches have been reported. Open techniques afford management of the entire proximal biceps tendon but are limited by wound healing issues, increased bleeding, and increased surgical time. Arthroscopic tenodesis offers benefits in terms of surgical efficiency, cosmesis, and bleeding risk. However, standard arthroscopic tenodesis only addresses intra-articular biceps pathology...
February 2024: Arthroscopy Techniques
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JOURNAL ARTICLE
Young-Taek Park, Dongwoon Han, Kyoung-Hoon Kim, Hoguen Kim, Hojung Joseph Yoon, Chris Lane, Byeo-Ri Kim, Joo-Yeon Jeong
OBJECTIVES: This study aimed to evaluate the incidence of health insurance claims recording the cancer stage and TNM codes representing tumor extension size (T), lymph node metastasis (N), and distant metastasis (M) for patients diagnosed with cancer and to determine whether this extracted data could be applied to the new ICD-11 codes. DESIGN: A cross-sectional study design was used, with the units of analysis as individual outpatients. Two dependent variables were extraction feasibility of cancer stage and TNM metastasis information from each claim...
February 24, 2024: BMJ Open
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RANDOMIZED CONTROLLED TRIAL
Tim A D Smith, Catharine M L West, Nuradh Joseph, Brian Lane, Joely Irlam-Jones, Elisabet More, Hitesh Mistry, Kimberley J Reeves, Yee Pei Song, Mark Reardon, Peter J Hoskin, Syed A Hussain, Helen Denley, Emma Hall, Nuria Porta, Robert A Huddart, Nick D James, Ananya Choudhury
BACKGROUND: BC2001 showed combining chemotherapy (5-FU + mitomycin-C) with radiotherapy improves loco-regional disease-free survival in patients with muscle-invasive bladder cancer (MIBC). We previously showed a 24-gene hypoxia-associated signature predicted benefit from hypoxia-modifying radiosensitisation in BCON and hypothesised that only patients with low hypoxia scores (HSs) would benefit from chemotherapy in BC2001. BC2001 allowed conventional (64Gy/32 fractions) or hypofractionated (55Gy/20 fractions) radiotherapy...
March 2024: EBioMedicine
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JOURNAL ARTICLE
Zhaorui Wang, Mark D Wishman, Teerapat Tutaworn, Isabelle G Hentschel, Justin E Levin, Joseph M Lane
PURPOSE: Cement usage in total hip arthroplasty (THA) is increasingly common. However, osteoporosis-related fracture risk in cemented vs uncemented THA patients is poorly characterized. We aim to analyze the usage of metabolic bone care and osteoporosis fracture risk in cemented vs uncemented THA patients using FRAX and radiographic bone measurements. METHODS: Chart review on 250 THA patients was performed retrospectively. Demographics, FRAX scores, hip radiograph measurements, osteoporosis diagnosis, treatment and screening were compared between cemented and uncemented THA patients...
February 19, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#8
REVIEW
Klaus Winter, Joseph A M Holtum
Five decades ago, the first report of a shift from C3 to CAM (crassulacean acid metabolism) photosynthesis following the imposition of stress was published in this journal. The annual, Mesembryanthemum crystallinum (Aizoaceae), was shown to be a C3 plant when grown under non-saline conditions, and a CAM plant when exposed to high soil salinity. This observation of environmentally triggered CAM eventually led to the introduction of the term facultative CAM, which categorises CAM that is induced or upregulated in response to water-deficit stress and is lost or downregulated when the stress is removed...
January 28, 2024: Journal of Plant Physiology
#9
JOURNAL ARTICLE
Jessen V Bredeson, Austin B Mudd, Sofia Medina-Ruiz, Therese Mitros, Owen Kabnick Smith, Kelly E Miller, Jessica B Lyons, Sanjit S Batra, Joseph Park, Kodiak C Berkoff, Christopher Plott, Jane Grimwood, Jeremy Schmutz, Guadalupe Aguirre-Figueroa, Mustafa K Khokha, Maura Lane, Isabelle Philipp, Mara Laslo, James Hanken, Gwenneg Kerdivel, Nicolas Buisine, Laurent M Sachs, Daniel R Buchholz, Taejoon Kwon, Heidi Smith-Parker, Marcos Gridi-Papp, Michael J Ryan, Robert D Denton, John H Malone, John B Wallingford, Aaron F Straight, Rebecca Heald, Dirk Hockemeyer, Richard M Harland, Daniel S Rokhsar
Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate cell and developmental model systems, notably the genus Xenopus. Here we report a high-quality reference genome sequence for the western clawed frog, Xenopus tropicalis, along with draft chromosome-scale sequences of three distantly related emerging model frog species, Eleutherodactylus coqui, Engystomops pustulosus, and Hymenochirus boettgeri. Frog chromosomes have remained remarkably stable since the Mesozoic Era, with limited Robertsonian (i...
January 17, 2024: Nature Communications
#10
JOURNAL ARTICLE
Lisa A Mandl, Mangala Rajan, Robyn A Lipschultz, Serena Lian, Dina Sheira, Marianna B Frey, Yvonne M Shea, Joseph M Lane
OBJECTIVES: To evaluate if social isolation or loneliness is associated with outcomes 1 year after low energy hip fracture. DESIGN: Prospective inception cohort study. SETTING: Academic Level I Trauma Center. PATIENT SELECTION CRITERIA: Participants were ≥ 65 years of age and enrolled 2-4 days after surgery for a first low energy hip fracture. Exclusion criteria were bilateral or periprosthetic hip fracture, previous hip fracture, non-English speaking, international address, active cancer, stage 4 cancer in the past 5 years, radiation to the hip region and cognitive impairment...
January 12, 2024: Journal of Orthopaedic Trauma
#11
JOURNAL ARTICLE
David M Desmet, Meghan E Kazanski, Joseph P Cusumano, Jonathan B Dingwell
BACKGROUND: Walking requires frequent maneuvers to navigate changing environments with shifting goals. Humans accomplish maneuvers and simultaneously maintain balance primarily by modulating their foot placement, but a direct trade-off between these two objectives has been proposed. As older adults may rely more on foot placement to maintain lateral balance, they may be less able to adequately adapt stepping to perform lateral maneuvers. RESEARCH QUESTION: How do older adults adapt stepping to enact lateral lane-change maneuvers, and how do physical and perceived ability influence their task performance? METHODS: Twenty young (21...
November 24, 2023: Gait & Posture
#12
JOURNAL ARTICLE
Jonathan B Dingwell, Anna C Render, David M Desmet, Joseph P Cusumano
People rarely walk in straight lines. Instead, we make frequent turns or other maneuvers. Spatiotemporal parameters fundamentally characterize gait. For straight walking, these parameters are well-defined for the task of walking on a straight path. Generalizing these concepts to non-straight walking, however, is not straightforward. People follow non-straight paths imposed by their environment (sidewalk, windy hiking trail, etc.) or choose readily-predictable, stereotypical paths of their own. People actively maintain lateral position to stay on their path and readily adapt their stepping when their path changes...
October 19, 2023: Journal of Biomechanics
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JOURNAL ARTICLE
Gabby B Joseph, Melia Takakusagi, Gino Arcilla, John A Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E Lane, Michael C Nevitt, Charles E McCulloch, Thomas M Link
OBJECTIVE: To assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4-years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness. DESIGN: Individuals from the Osteoarthritis Initiative (total=399) with >10% weight gain (n=100) and >10% weight loss (n=100) over 4 years were compared to a matched control cohort with less than 3% change in weight (n=199)...
August 11, 2023: Osteoarthritis and Cartilage
#14
JOURNAL ARTICLE
Irma M Vlasac, Gregory W Bormes, Elizabeth Do, Selma S Benkhoukha, Naby Diallo, Noah L Fryou, Siena Gioia, Oluwaseun Akeju, Clarence Joseph, Anne Kuan, Jennifer Lapan, David Oluwadara, The Pepper Team, Shadab A Rahman, Richa Saxena, Frank A J L Scheer, M Brandon Westover, John W Winkelman, Faraji Woodson, Jacqueline M Lane
The Circadia Study (Circadia) is a novel "direct-to-participant" research study investigating the genetics of circadian rhythm disorders of advanced and delayed sleep phase and non-24 hour rhythms. The goals of the Circadia Study are twofold: (i) to create an easy-to-use toolkit for at-home circadian phase assessment for patients with circadian rhythm disorders through the use of novel in-home based surveys, tests, and collection kits; and (ii) create a richly phenotyped patient resource for genetic studies that will lead to new genetic loci associated with circadian rhythm disorders revealing possible loci of interest to target in the development of therapeutics for circadian rhythm disorders...
August 9, 2023: Sleep
#15
JOURNAL ARTICLE
Joseph C Brinkman, Kade S McQuivey, Jeffrey D Hassebrock, M Lane Moore, Jordan R Pollock, John M Tokish
PURPOSE: To quantify and analyze public interest trends in platelet-rich plasma (PRP) therapy for shoulder pathology between 2011 and 2020 using Google Trends data. METHODS: Google Trends data were queried for online search data ranging from January 2011 to December 2020. Various combinations of terms related to PRP and shoulder pathology were queried. Terms related to corticosteroid therapy in association with shoulder pathology were also generated for comparative analysis...
August 2023: Arthroscopy, sports medicine, and rehabilitation
#16
JOURNAL ARTICLE
Joseph M Lane, Witchaporn Witayakom
No abstract text is available yet for this article.
July 20, 2023: Journal of Bone and Joint Surgery. American Volume
#17
JOURNAL ARTICLE
Mikita Fuchita, Jack Pattee, Derek W Russell, Brian E Driver, Matthew E Prekker, Christopher R Barnes, Joseph M Brewer, Kevin C Doerschug, John P Gaillard, Sheetal Gandotra, Shekhar Ghamande, Kevin W Gibbs, Christopher G Hughes, David R Janz, Akram Khan, Steven H Mitchell, David B Page, Todd W Rice, Wesley H Self, Lane M Smith, Susan B Stempek, Stacy A Trent, Derek J Vonderhaar, Jason R West, Micah R Whitson, Kayla Williamson, Matthew W Semler, Jonathan D Casey, Adit A Ginde
UNLABELLED: Hypotension affects approximately 40% of critically ill patients undergoing emergency intubation and is associated with an increased risk of death. The objective of this study was to examine the association between prophylactic vasopressor administration and the incidence of peri-intubation hypotension and other clinical outcomes. DESIGN: A secondary analysis of two multicenter randomized clinical trials. The clinical effect of prophylactic vasopressor administration was estimated using a one-to-one propensity-matched cohort of patients with and without prophylactic vasopressors...
July 2023: Critical care explorations
#18
JOURNAL ARTICLE
Sayi P Boddu, Vikram S Gill, M Lane Moore, Jack M Haglin, Cara H Lai, Joseph C Brinkman, Anikar Chhabra
BACKGROUND: There is a wide range of literature on patellar tendon injury, making it increasingly difficult to stay informed on the most influential studies in this field. It is essential to be familiar with the foundational articles of patellar tendon injury research to understand the current state of the literature and deliver high quality care. PURPOSE: To objectively identify the 50 most influential articles relating to patellar tendon injury and conduct a bibliometric analysis to identify key features of these articles...
July 2023: Orthopaedic Journal of Sports Medicine
#19
JOURNAL ARTICLE
Jamie F Dulle, M Lane Moore, Joseph C Brinkman, Jordan R Pollock, Donald L Dulle, Anna S Jenkins, Anikar Chhabra
PURPOSE: To determine the most frequently cited articles relating to ice hockey since 2000 and conduct a bibliometric analysis of these publications. METHODS: The Clarivate Web of Knowledge database was used to gather data and generate a list of publications relating to "ice hockey" on June 20, 2022. Articles were filtered by the total number of citations accrued and were included or excluded on the basis of relevance to ice hockey; no date of publication, language, or journal restrictions...
June 2023: Arthroscopy, sports medicine, and rehabilitation
#20
JOURNAL ARTICLE
Tong Qiu, Marie-Claire Aravena, Davide Ascoli, Yves Bergeron, Michal Bogdziewicz, Thomas Boivin, Raul Bonal, Thomas Caignard, Maxime Cailleret, Rafael Calama, Sergio Donoso Calderon, J Julio Camarero, Chia-Hao Chang-Yang, Jerome Chave, Francesco Chianucci, Benoit Courbaud, Andrea Cutini, Adrian J Das, Nicolas Delpierre, Sylvain Delzon, Michael Dietze, Laurent Dormont, Josep Maria Espelta, Timothy J Fahey, William Farfan-Rios, Jerry F Franklin, Catherine A Gehring, Gregory S Gilbert, Georg Gratzer, Cathryn H Greenberg, Arthur Guignabert, Qinfeng Guo, Andrew Hacket-Pain, Arndt Hampe, Qingmin Han, Jan Holik, Kazuhiko Hoshizaki, Ines Ibanez, Jill F Johnstone, Valentin Journé, Thomas Kitzberger, Johannes M H Knops, Georges Kunstler, Hiroko Kurokawa, Jonathan G A Lageard, Jalene M LaMontagne, Francois Lefevre, Theodor Leininger, Jean-Marc Limousin, James A Lutz, Diana Macias, Anders Marell, Eliot J B McIntire, Christopher M Moore, Emily Moran, Renzo Motta, Jonathan A Myers, Thomas A Nagel, Shoji Naoe, Mahoko Noguchi, Michio Oguro, Robert Parmenter, Ian S Pearse, Ignacio M Perez-Ramos, Lukasz Piechnik, Tomasz Podgorski, John Poulsen, Miranda D Redmond, Chantal D Reid, Kyle C Rodman, Francisco Rodriguez-Sanchez, Pavel Samonil, Javier D Sanguinetti, C Lane Scher, Barbara Seget, Shubhi Sharma, Mitsue Shibata, Miles Silman, Michael A Steele, Nathan L Stephenson, Jacob N Straub, Samantha Sutton, Jennifer J Swenson, Margaret Swift, Peter A Thomas, Maria Uriarte, Giorgio Vacchiano, Amy V Whipple, Thomas G Whitham, Andreas P Wion, S Joseph Wright, Kai Zhu, Jess K Zimmerman, Magdalena Zywiec, James S Clark
The benefits of masting (volatile, quasi-synchronous seed production at lagged intervals) include satiation of seed predators, but these benefits come with a cost to mutualist pollen and seed dispersers. If the evolution of masting represents a balance between these benefits and costs, we expect mast avoidance in species that are heavily reliant on mutualist dispersers. These effects play out in the context of variable climate and site fertility among species that vary widely in nutrient demand. Meta-analyses of published data have focused on variation at the population scale, thus omitting periodicity within trees and synchronicity between trees...
June 29, 2023: Nature Plants
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