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Joseph M Lane

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https://www.readbyqxmd.com/read/28926388/opportunistic-use-of-ct-imaging-for-osteoporosis-screening-and-bone-density-assessment-a-qualitative-systematic-review
#1
REVIEW
Elizabeth B Gausden, Benedict U Nwachukwu, Joseph J Schreiber, Dean G Lorich, Joseph M Lane
BACKGROUND: The purpose of this study was to determine the clinical opportunities for the use of computed tomography (CT) imaging for inferring bone quality and to critically analyze the correlation between dual x-ray absorptiometry (DXA) and diagnostic CT as reported in the literature. METHODS: A systematic review of the MEDLINE database was performed in February 2016 using the PubMed interface. The inclusion criteria were English language, studies performed using living human subjects, studies pertaining to orthopaedics, use of conventional diagnostic CT scans, studies that measured cancellous bone, and studies that reported Hounsfield unit (HU) measurements directly rather than a computed bone mineral density...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28917261/development-of-standard-reference-material-srm-2973-vitamin-d-metabolites-in-frozen-human-serum-high-level
#2
Susan S-C Tai, Michael A Nelson, Mary Bedner, Brian E Lang, Karen W Phinney, Lane C Sander, James H Yen, Joseph M Betz, Christopher T Sempos, Stephen A Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements and the Vitamin D Standardization Program, has recently issued a new serum-matrix Standard Reference Material (SRM): 2973 Vitamin D Metabolites in Frozen Human Serum (High Level). SRM 2973 was designed to provide a serum material with a total 25-hydroxyvitamin D [25(OH)D] concentration near 100 nmol/L to complement the existing serum-based SRMs with values assigned for total 25(OH)D between 20 and 80 nmol/L...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#3
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28763418/tracking-cumulative-radiation-exposure-in-orthopaedic-surgeons-and-residents-what-dose-are-we-getting
#4
Elizabeth B Gausden, Alexander B Christ, Roseann Zeldin, Joseph M Lane, Moira M McCarthy
BACKGROUND: The purpose of this study was to determine the amount of cumulative radiation exposure received by orthopaedic surgeons and residents in various subspecialties. We obtained dosimeter measures over 12 months on 24 residents and 16 attending surgeons. METHODS: Monthly radiation exposure was measured over a 12-month period for 24 orthopaedic residents and 16 orthopaedic attending surgeons. The participants wore a Landauer Luxel dosimeter on the breast pocket of their lead apron...
August 2, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28760963/atypical-fracture-with-long-term-bisphosphonate-therapy-is-associated-with-altered-cortical-composition-and-reduced-fracture-resistance
#5
Ashley A Lloyd, Bernd Gludovatz, Christoph Riedel, Emma A Luengo, Rehan Saiyed, Eric Marty, Dean G Lorich, Joseph M Lane, Robert O Ritchie, Björn Busse, Eve Donnelly
Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughening mechanisms in cortical bone. The objective of this study was to compare the compositional and mechanical properties of bone biopsies from bisphosphonate-treated patients with AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate treatment...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28623654/value-assignment-of-vitamin-d-metabolites-in-vitamin-d-standardization-program-serum-samples
#6
Karen W Phinney, Johanna E Camara, Susan S-C Tai, Lane C Sander, Stephen A Wise, Linde A C De Grande, Linda M Thienpont, Antonio M Possolo, Blaza Toman, Christopher T Sempos, Joseph M Betz, Paul M Coates
Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as reference measurement procedures (RMPs) by the Joint Committee for Traceability in Laboratory Medicine. These samples and their assigned values serve as the foundation for several aspects of the VDSP...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623114/characterizing-the-relationship-between-surgical-resident-and-faculty-perceptions-of-autonomy-in-the-operating-room
#7
Katelyn A Young, Samantha M Lane, John E Widger, Nina M Neuhaus, James T Dove, Marcus Fluck, Marie A Hunsinger, Joseph A Blansfield, Mohsen M Shabahang
OBJECTIVE: Characterize the concordance among faculty and resident perceptions of surgical case complexity, resident technical performance, and autonomy in a diverse sample of general surgery procedures using case-specific evaluations. DESIGN: A prospective study was conducted in which a faculty surgeon and surgical resident independently completed a postoperative assessment examining case complexity, resident operative performance (Milestone assessment) and autonomy (Zwisch model)...
June 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28610546/neuromuscular-electrical-stimulation-for-the-prevention-of-venous-thromboembolism
#8
Raveena Ravikumar, Katherine J Williams, Adarsh Babber, Hayley M Moore, Tristan Ra Lane, Joseph Shalhoub, Alun H Davies
Objective Venous thromboembolism, encompassing deep vein thrombosis and pulmonary embolism, is a significant cause of morbidity and mortality, affecting one in 1000 adults per year. Neuromuscular electrical stimulation is the transcutaneous application of electrical impulses to elicit muscle contraction, preventing venous stasis. This review aims to investigate the evidence underlying the use of neuromuscular electrical stimulation in thromboprophylaxis. Methods The Medline and Embase databases were systematically searched, adhering to PRISMA guidelines, for articles relating to electrical stimulation and thromboprophylaxis...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28604576/diagnosing-large-vestibular-aqueduct-radiological-review-of-high-resolution-ct-versus-high-resolution-volumetric-mri
#9
Nicholas L Deep, Matthew L Carlson, Steven M Weindling, David M Barrs, Colin L W Driscoll, Christine M Lohse, John I Lane, Joseph M Hoxworth
OBJECTIVES: To compare the diagnostic yield of high-resolution volumetric T2-weighted MRI (HRT2-MRI) with high-resolution computed tomography (HRCT) for diagnosis of large vestibular aqueduct (LVA). STUDY DESIGN: Three board-certified neuroradiologists performed an independent, blinded radiological review for diagnosing LVA with 2:1 age-matched controls on patients with both HRCT and HRT2-MRI imaging. SETTING: Tertiary referral center. PATIENTS: All patients between 2002 and 2016 with hearing loss who underwent both HRCT and HRT2-MRI and were diagnosed with LVA on either modality...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28556419/association-of-diabetes-mellitus-and-biochemical-knee-cartilage-composition-assessed-by-t2-relaxation-time-measurements-data-from-the-osteoarthritis-initiative
#10
Nattagan Chanchek, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Jan Neumann, Gabby B Joseph, Nancy E Lane, Julia Zarnowski, Felix C Hofmann, Ursula Heilmeier, Charles E McCulloch, Thomas M Link
PURPOSE: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. MATERIALS AND METHODS: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63...
May 26, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28498854/single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#11
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28445186/the-hip-fracture-patient-on-warfarin-evaluating-blood-loss-and-time-to-surgery
#12
Matthew R Cohn, Ashley E Levack, Nikunj N Trivedi, Jordan C Villa, David S Wellman, John P Lyden, Dean G Lorich, Joseph M Lane
OBJECTIVES: To compare blood loss, delay of surgery, and short-term adverse events in (1) patients admitted on warfarin versus nonanticoagulated controls and (2) warfarin patients with day of surgery (DOS) international normalized ratio (INR) of 1.5 or greater versus below 1.5. DESIGN: Retrospective cohort. SETTING: Academic Level I trauma center. PATIENTS/PARTICIPANTS: One hundred twenty four patients treated surgically for hip fractures including patients presenting on warfarin (n = 62) and matched controls (n = 62)...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28437188/further-characterization-of-the-mitigation-of-radiation-lethality-by-protective-wounding
#13
Joseph R Dynlacht, Joy Garrett, Rebecca Joel, Katharina Lane, Marc S Mendonca, Christie M Orschell
There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological terrorist attack. The ideal countermeasure should be effective when administered after exposure, and over a wide range of absorbed doses. We have previously shown that the administration of a subcutaneous incision of a defined length, if administered within minutes after irradiation, protected young adult female C57BL/6 mice against radiation-induced lethality, and increased survival after total-body exposure to an LD50/30 X-ray dose from 50% to over 90%...
June 2017: Radiation Research
https://www.readbyqxmd.com/read/28426267/a-phase-2-trial-of-single-agent-axitinib-as-maintenance-therapy-following-first-line-treatment-with-modified-folfox-bevacizumab-in-patients-with-metastatic-colorectal-cancer
#14
Johanna C Bendell, Mathew Joseph, Kirk Barnes, Mark Mainwaring, Dianna Shipley, Chandra Reddy, Laura Blakely, Ronald Blachly, Cassie M Lane, Chris Earwood, Michel Kuzur
This phase-2 trial evaluated the efficacy of axitinib as maintenance therapy for patients with metastatic colorectal cancer (mCRC) following first-line treatment with FOLFOX/bevacizumab. Patients with mCRC received mFOLFOX/bevacizumab followed by axitinib maintenance after four cycles. The primary endpoint was progression-free survival (PFS). Seventy patients were enrolled. Common treatment-related toxicities were fatigue, nausea, diarrhea, and peripheral neuropathy during FOLFOX/bevacizumab treatment; and fatigue, hypertension, diarrhea, and peripheral neuropathy during axitinib treatment...
July 3, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28375002/development-of-an-improved-standard-reference-material-for-vitamin-d-metabolites-in-human-serum
#15
Karen W Phinney, Susan S-C Tai, Mary Bedner, Johanna E Camara, Rosalind R C Chia, Lane C Sander, Katherine E Sharpless, Stephen A Wise, James H Yen, Rosemary L Schleicher, Madhulika Chaudhary-Webb, Khin L Maw, Yasamin Rahmani, Joseph M Betz, Joyce Merkel, Christopher T Sempos, Paul M Coates, Ramón A Durazo-Arvizu, Kurtis Sarafin, Stephen P J Brooks
The National Institute of Standards and Technology (NIST) has developed Standard Reference Material (SRM) 972a Vitamin D Metabolites in Frozen Human Serum as a replacement for SRM 972, which is no longer available. SRM 972a was developed in collaboration with the National Institutes of Health's Office of Dietary Supplements. In contrast to the previous reference material, three of the four levels of SRM 972a are composed of unmodified human serum. This SRM has certified and reference values for the following 25-hydroxyvitamin D [25(OH)D] species: 25(OH)D2, 25(OH)D3, and 3-epi-25(OH)D3...
May 2, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28262568/a-bleeding-assessment-tool-correlates-with-intraoperative-blood-loss-in-children-and-adolescents-undergoing-major-spinal-surgery
#16
Jennifer M Anadio, Peter F Sturm, Johan M Forslund, Sunil Agarwal, Adam Lane, Cristina Tarango, Joseph S Palumbo
Screening laboratory studies for bleeding disorders are of little predictive value for operative bleeding risk in adults. Predicting perioperative bleeding in pediatric patients is particularly difficult as younger patients often have not had significant hemostatic challenges. This issue is distinctly important for high bleeding risk surgeries, such as major spinal procedures. The aim of this study was to determine if the score of a detailed bleeding questionnaire (BQ) correlated with surgical bleeding in pediatric patients undergoing major spinal surgery...
April 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28241211/families-as-partners-in-hospital-error-and-adverse-event-surveillance
#17
Alisa Khan, Maitreya Coffey, Katherine P Litterer, Jennifer D Baird, Stephannie L Furtak, Briana M Garcia, Michele A Ashland, Sharon Calaman, Nicholas C Kuzma, Jennifer K O'Toole, Aarti Patel, Glenn Rosenbluth, Lauren A Destino, Jennifer L Everhart, Brian P Good, Jennifer H Hepps, Anuj K Dalal, Stuart R Lipsitz, Catherine S Yoon, Katherine R Zigmont, Rajendu Srivastava, Amy J Starmer, Theodore C Sectish, Nancy D Spector, Daniel C West, Christopher P Landrigan, Brenda K Allair, Claire Alminde, Wilma Alvarado-Little, Marisa Atsatt, Megan E Aylor, James F Bale, Dorene Balmer, Kevin T Barton, Carolyn Beck, Zia Bismilla, Rebecca L Blankenberg, Debra Chandler, Amanda Choudhary, Eileen Christensen, Sally Coghlan-McDonald, F Sessions Cole, Elizabeth Corless, Sharon Cray, Roxi Da Silva, Devesh Dahale, Benard Dreyer, Amanda S Growdon, LeAnn Gubler, Amy Guiot, Roben Harris, Helen Haskell, Irene Kocolas, Elizabeth Kruvand, Michele Marie Lane, Kathleen Langrish, Christy J W Ledford, Kheyandra Lewis, Joseph O Lopreiato, Christopher G Maloney, Amanda Mangan, Peggy Markle, Fernando Mendoza, Dale Ann Micalizzi, Vineeta Mittal, Maria Obermeyer, Katherine A O'Donnell, Mary Ottolini, Shilpa J Patel, Rita Pickler, Jayne Elizabeth Rogers, Lee M Sanders, Kimberly Sauder, Samir S Shah, Meesha Sharma, Arabella Simpkin, Anupama Subramony, E Douglas Thompson, Laura Trueman, Tanner Trujillo, Michael P Turmelle, Cindy Warnick, Chelsea Welch, Andrew J White, Matthew F Wien, Ariel S Winn, Stephanie Wintch, Michael Wolf, H Shonna Yin, Clifton E Yu
Importance: Medical errors and adverse events (AEs) are common among hospitalized children. While clinician reports are the foundation of operational hospital safety surveillance and a key component of multifaceted research surveillance, patient and family reports are not routinely gathered. We hypothesized that a novel family-reporting mechanism would improve incident detection. Objective: To compare error and AE rates (1) gathered systematically with vs without family reporting, (2) reported by families vs clinicians, and (3) reported by families vs hospital incident reports...
April 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27871088/structure-of-photosystem-ii-and-substrate-binding-at-room-temperature
#18
Iris D Young, Mohamed Ibrahim, Ruchira Chatterjee, Sheraz Gul, Franklin Fuller, Sergey Koroidov, Aaron S Brewster, Rosalie Tran, Roberto Alonso-Mori, Thomas Kroll, Tara Michels-Clark, Hartawan Laksmono, Raymond G Sierra, Claudiu A Stan, Rana Hussein, Miao Zhang, Lacey Douthit, Markus Kubin, Casper de Lichtenberg, Pham Long Vo, Håkan Nilsson, Mun Hon Cheah, Dmitriy Shevela, Claudio Saracini, Mackenzie A Bean, Ina Seuffert, Dimosthenis Sokaras, Tsu-Chien Weng, Ernest Pastor, Clemens Weninger, Thomas Fransson, Louise Lassalle, Philipp Bräuer, Pierre Aller, Peter T Docker, Babak Andi, Allen M Orville, James M Glownia, Silke Nelson, Marcin Sikorski, Diling Zhu, Mark S Hunter, Thomas J Lane, Andy Aquila, Jason E Koglin, Joseph Robinson, Mengning Liang, Sébastien Boutet, Artem Y Lyubimov, Monarin Uervirojnangkoorn, Nigel W Moriarty, Dorothee Liebschner, Pavel V Afonine, David G Waterman, Gwyndaf Evans, Philippe Wernet, Holger Dobbek, William I Weis, Axel T Brunger, Petrus H Zwart, Paul D Adams, Athina Zouni, Johannes Messinger, Uwe Bergmann, Nicholas K Sauter, Jan Kern, Vittal K Yachandra, Junko Yano
Light-induced oxidation of water by photosystem II (PS II) in plants, algae and cyanobacteria has generated most of the dioxygen in the atmosphere. PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). Under illumination, the OEC cycles through five intermediate S-states (S0 to S4), in which S1 is the dark-stable state and S3 is the last semi-stable state before O-O bond formation and O2 evolution...
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27741156/the-role-of-oligosaccharides-in-host-microbial-interactions-for-human-health
#19
Sarah A Ross, Jonathan A Lane, Mariarosaria Marotta, Devon Kavanaugh, Joseph Thomas Ryan, Lokesh Joshi, Rita M Hickey
Milk oligosaccharides have many associated bioactivities which can contribute to human health and offer protective properties to the host. Such bioactivities include anti-infective properties whereby oligosaccharides interact with bacterial cells and prevent adhesion to the host and subsequent colonization. Milk oligosaccharides have also been shown to alter the glycosylation of intestinal cells, leading to a reduction in pathogenic colonization. In addition, these sugars promote adhesion of commensal bacterial strains to host cells as well as possessing the ability to alter mucin expression in intestinal cells and improve barrier function...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27711844/femtosecond-photodissociation-dynamics-of-1-4-diiodobenzene-by-gas-phase-x-ray-scattering-and-photoelectron-spectroscopy
#20
Brian Stankus, James M Budarz, Adam Kirrander, David Rogers, Joseph Robinson, Thomas J Lane, Daniel Ratner, Jerome Hastings, Michael P Minitti, Peter M Weber
We present a multifaceted investigation into the initial photodissociation dynamics of 1,4-diiodobenzene (DIB) following absorption of 267 nm radiation. We combine ultrafast time-resolved photoelectron spectroscopy and X-ray scattering experiments performed at the Linac Coherent Light Source (LCLS) to study the initial electronic excitation and subsequent rotational alignment, and interpret the experiments in light of Complete Active Space Self-Consistent Field (CASSCF) calculations of the excited electronic landscape...
December 16, 2016: Faraday Discussions
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