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Joseph M Lane

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https://www.readbyqxmd.com/read/29750786/correction-single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#1
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29605381/type-2-diabetes-patients-have-accelerated-cartilage-matrix-degeneration-compared-to-diabetes-free-controls-data-from-the-osteoarthritis-initiative
#2
Jan Neumann, Felix C Hofmann, Ursula Heilmeier, Walid Ashmeik, Kenneth Tang, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Gabby B Joseph, Nancy E Lane, Charles E McCulloch, Thomas M Link
PURPOSE: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. METHODS: From the Osteoarthritis Initiative cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren-Lawrence score with 196 non-diabetic controls...
March 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#3
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29358052/lipids-shape-the-electron-acceptor-binding-site-of-the-peripheral-membrane-protein-dihydroorotate-dehydrogenase
#4
Joana Costeira-Paulo, Joseph Gault, Gergana Popova, Marcus J G W Ladds, Ingeborg M M van Leeuwen, Médoune Sarr, Anders Olsson, David P Lane, Sonia Laín, Erik G Marklund, Michael Landreh
The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, and inhibitor binding in the peripheral membrane protein dihydroorotate dehydrogenase (DHODH), a key anticancer target. Interrogation of intact DHODH complexes by MS reveals that phospholipids bind via their charged head groups at a limited number of sites, while binding of the inhibitor brequinar involves simultaneous association with detergent molecules...
March 15, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29198854/efficacy-and-safety-of-transversus-abdominis-plane-blocks-versus-thoracic-epidural-anesthesia-in-patients-undergoing-major-abdominal-oncologic-resections-a-prospective-randomized-controlled-trial
#5
Tamer M Shaker, Joseph T Carroll, Mathew H Chung, Tracy J Koehler, Brian R Lane, Andrea M Wolf, G Paul Wright
BACKGROUND: The purpose of this study was to compare patient outcomes for thoracic epidural anesthesia (TEA) with transversus abdominis plane (TAP) blocks. METHODS: A prospective, randomized trial was performed for patients undergoing abdominal oncologic surgeries. RESULTS: There were 32 TAP and 35 TEA subjects. The TEA group demonstrated increased episodes of hypotension in the first 24 h (3 v 0.6, p = 0.02). There was no difference in 24-48 h fluid balance between the groups...
March 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29143404/tool-for-osteoarthritis-risk-prediction-toarp-over-8-years-using-baseline-clinical-data-x-ray-and-mri-data-from-the-osteoarthritis-initiative
#6
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Jan Neumann, Alexandra S Gersing, Martin Kretzschmar, Benedikt J Schwaiger, John A Lynch, Ursula Heilmeier, Nancy E Lane, Thomas M Link
BACKGROUND: Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often leads to severe disability. The rising rates of disability highlight the need for implementing preventative measures at early stages of the disease, which would especially benefit subjects at high risk for OA development. PURPOSE: To develop a risk prediction tool for moderate-severe OA (TOARP) over 8 years based on subject characteristics, knee radiographs, and MRI data at baseline using data from the Osteoarthritis Initiative (OAI)...
November 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29059109/metabolic-bone-diseases-and-total-hip-arthroplasty-preventing-complications
#7
REVIEW
Joaquin Moya-Angeler, Joseph M Lane, Jose A Rodriguez
Metabolic bone diseases are a diverse group of conditions characterized by abnormalities in calcium metabolism and/or bone cell physiology. These unbalanced processes can eventually lead to bony deformities and altered joint biomechanics, resulting in degenerative joint disease. Not infrequently, patients with metabolic bone diseases have restricting hip joint pain that ultimately necessitates hip arthroplasty. To minimize complications, the surgeon must consider the particular characteristics of these patients...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29021218/transcriptomic-analysis-of-octanoic-acid-response-in-drosophila-sechellia-using-rna-sequencing
#8
Stephen M Lanno, Sara M Gregory, Serena J Shimshak, Maximilian K Alverson, Kenneth Chiu, Arden L Feil, Morgan G Findley, Taylor E Forman, Julia T Gordon, Josephine Ho, Joanna L Krupp, Ivy Lam, Josh Lane, Samuel C Linde, Ashley E Morse, Serena Rusk, Robie Ryan, Avva Saniee, Ruchi B Sheth, Jennifer J Siranosian, Lalitpatr Sirichantaropart, Sonya R Sternlieb, Christina M Zaccardi, Joseph D Coolon
The dietary specialist fruit fly Drosophila sechellia has evolved to specialize on the toxic fruit of its host plant Morinda citrifolia Toxicity of Morinda fruit is primarily due to high levels of octanoic acid (OA). Using RNA interference (RNAi), prior work found that knockdown of Osiris family genes Osiris 6 ( Osi6 ), Osi7 , and Osi8 led to increased susceptibility to OA in adult D. melanogaster flies, likely representing genes underlying a Quantitative Trait Locus (QTL) for OA resistance in D. sechellia While genes in this major effect locus are beginning to be revealed, prior work has shown at least five regions of the genome contribute to OA resistance...
December 4, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28926388/opportunistic-use-of-ct-imaging-for-osteoporosis-screening-and-bone-density-assessment-a-qualitative-systematic-review
#9
REVIEW
Elizabeth B Gausden, Benedict U Nwachukwu, Joseph J Schreiber, Dean G Lorich, Joseph M Lane
BACKGROUND: The purpose of this study was to determine the clinical opportunities for the use of computed tomography (CT) imaging for inferring bone quality and to critically analyze the correlation between dual x-ray absorptiometry (DXA) and diagnostic CT as reported in the literature. METHODS: A systematic review of the MEDLINE database was performed in February 2016 using the PubMed interface. The inclusion criteria were English language, studies performed using living human subjects, studies pertaining to orthopaedics, use of conventional diagnostic CT scans, studies that measured cancellous bone, and studies that reported Hounsfield unit (HU) measurements directly rather than a computed bone mineral density...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28917261/development-of-standard-reference-material-srm-2973-vitamin-d-metabolites-in-frozen-human-serum-high-level
#10
Susan S-C Tai, Michael A Nelson, Mary Bedner, Brian E Lang, Karen W Phinney, Lane C Sander, James H Yen, Joseph M Betz, Christopher T Sempos, Stephen A Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements and the Vitamin D Standardization Program, has recently issued a new serum-matrix Standard Reference Material (SRM): 2973 Vitamin D Metabolites in Frozen Human Serum (High Level). SRM 2973 was designed to provide a serum material with a total 25-hydroxyvitamin D [25(OH)D] concentration near 100 nmol/L to complement the existing serum-based SRMs with values assigned for total 25(OH)D between 20 and 80 nmol/L...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#11
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28763418/tracking-cumulative-radiation-exposure-in-orthopaedic-surgeons-and-residents-what-dose-are-we-getting
#12
Elizabeth B Gausden, Alexander B Christ, Roseann Zeldin, Joseph M Lane, Moira M McCarthy
BACKGROUND: The purpose of this study was to determine the amount of cumulative radiation exposure received by orthopaedic surgeons and residents in various subspecialties. We obtained dosimeter measures over 12 months on 24 residents and 16 attending surgeons. METHODS: Monthly radiation exposure was measured over a 12-month period for 24 orthopaedic residents and 16 orthopaedic attending surgeons. The participants wore a Landauer Luxel dosimeter on the breast pocket of their lead apron...
August 2, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28760963/atypical-fracture-with-long-term-bisphosphonate-therapy-is-associated-with-altered-cortical-composition-and-reduced-fracture-resistance
#13
Ashley A Lloyd, Bernd Gludovatz, Christoph Riedel, Emma A Luengo, Rehan Saiyed, Eric Marty, Dean G Lorich, Joseph M Lane, Robert O Ritchie, Björn Busse, Eve Donnelly
Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughening mechanisms in cortical bone. The objective of this study was to compare the compositional and mechanical properties of bone biopsies from bisphosphonate-treated patients with AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate treatment...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28623654/value-assignment-of-vitamin-d-metabolites-in-vitamin-d-standardization-program-serum-samples
#14
Karen W Phinney, Johanna E Camara, Susan S-C Tai, Lane C Sander, Stephen A Wise, Linde A C De Grande, Linda M Thienpont, Antonio M Possolo, Blaza Toman, Christopher T Sempos, Joseph M Betz, Paul M Coates
Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as reference measurement procedures (RMPs) by the Joint Committee for Traceability in Laboratory Medicine. These samples and their assigned values serve as the foundation for several aspects of the VDSP...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623114/characterizing-the-relationship-between-surgical-resident-and-faculty-perceptions-of-autonomy-in-the-operating-room
#15
Katelyn A Young, Samantha M Lane, John E Widger, Nina M Neuhaus, James T Dove, Marcus Fluck, Marie A Hunsinger, Joseph A Blansfield, Mohsen M Shabahang
OBJECTIVE: Characterize the concordance among faculty and resident perceptions of surgical case complexity, resident technical performance, and autonomy in a diverse sample of general surgery procedures using case-specific evaluations. DESIGN: A prospective study was conducted in which a faculty surgeon and surgical resident independently completed a postoperative assessment examining case complexity, resident operative performance (Milestone assessment) and autonomy (Zwisch model)...
November 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28610546/neuromuscular-electrical-stimulation-for-the-prevention-of-venous-thromboembolism
#16
Raveena Ravikumar, Katherine J Williams, Adarsh Babber, Hayley M Moore, Tristan Ra Lane, Joseph Shalhoub, Alun H Davies
Objective Venous thromboembolism, encompassing deep vein thrombosis and pulmonary embolism, is a significant cause of morbidity and mortality, affecting one in 1000 adults per year. Neuromuscular electrical stimulation is the transcutaneous application of electrical impulses to elicit muscle contraction, preventing venous stasis. This review aims to investigate the evidence underlying the use of neuromuscular electrical stimulation in thromboprophylaxis. Methods The Medline and Embase databases were systematically searched, adhering to PRISMA guidelines, for articles relating to electrical stimulation and thromboprophylaxis...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28604576/diagnosing-large-vestibular-aqueduct-radiological-review-of-high-resolution-ct-versus-high-resolution-volumetric-mri
#17
COMPARATIVE STUDY
Nicholas L Deep, Matthew L Carlson, Steven M Weindling, David M Barrs, Colin L W Driscoll, Christine M Lohse, John I Lane, Joseph M Hoxworth
OBJECTIVES: To compare the diagnostic yield of high-resolution volumetric T2-weighted MRI (HRT2-MRI) with high-resolution computed tomography (HRCT) for diagnosis of large vestibular aqueduct (LVA). STUDY DESIGN: Three board-certified neuroradiologists performed an independent, blinded radiological review for diagnosing LVA with 2:1 age-matched controls on patients with both HRCT and HRT2-MRI imaging. SETTING: Tertiary referral center. PATIENTS: All patients between 2002 and 2016 with hearing loss who underwent both HRCT and HRT2-MRI and were diagnosed with LVA on either modality...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28556419/association-of-diabetes-mellitus-and-biochemical-knee-cartilage-composition-assessed-by-t-2-relaxation-time-measurements-data-from-the-osteoarthritis-initiative
#18
Nattagan Chanchek, Alexandra S Gersing, Benedikt J Schwaiger, Michael C Nevitt, Jan Neumann, Gabby B Joseph, Nancy E Lane, Julia Zarnowski, Felix C Hofmann, Ursula Heilmeier, Charles E McCulloch, Thomas M Link
PURPOSE: To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)-based T2 relaxation time measurements, and structural knee abnormalities. MATERIALS AND METHODS: In the Osteoarthritis Initiative 208, participants with DM (age 63.0 ± 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren-Lawrence [KL] grade ≤2) were identified and group-matched with 208 controls without DM (age 63...
February 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28498854/single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#19
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28445186/the-hip-fracture-patient-on-warfarin-evaluating-blood-loss-and-time-to-surgery
#20
Matthew R Cohn, Ashley E Levack, Nikunj N Trivedi, Jordan C Villa, David S Wellman, John P Lyden, Dean G Lorich, Joseph M Lane
OBJECTIVES: To compare blood loss, delay of surgery, and short-term adverse events in (1) patients admitted on warfarin versus nonanticoagulated controls and (2) warfarin patients with day of surgery (DOS) international normalized ratio (INR) of 1.5 or greater versus below 1.5. DESIGN: Retrospective cohort. SETTING: Academic Level I trauma center. PATIENTS/PARTICIPANTS: One hundred twenty four patients treated surgically for hip fractures including patients presenting on warfarin (n = 62) and matched controls (n = 62)...
August 2017: Journal of Orthopaedic Trauma
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