keyword
https://read.qxmd.com/read/35453858/comparison-of-qualitative-and-quantitative-analyses-of-mr-arterial-spin-labeling-perfusion-data-for-the-assessment-of-pediatric-patients-with-focal-epilepsies
#21
JOURNAL ARTICLE
Domenico Tortora, Matteo Cataldi, Mariasavina Severino, Alessandro Consales, Mattia Pacetti, Costanza Parodi, Fiammetta Sertorio, Antonia Ramaglia, Erica Cognolato, Giulia Nobile, Margherita Mancardi, Giulia Prato, Laura Siri, Thea Giacomini, Pasquale Striano, Dario Arnaldi, Gianluca Piatelli, Andrea Rossi, Lino Nobili
The role of MR Arterial-Spin-Labeling Cerebral Blood Flow maps (ASL-CBF) in the assessment of pediatric focal epilepsy is still debated. We aim to compare the Seizure Onset Zone (SOZ) detection rate of three methods of evaluation of ASL-CBF: 1) qualitative visual (qCBF), 2) z-score voxel-based quantitative analysis of index of asymmetry (AI-CBF), and 3) z-score voxel-based cluster analysis of the quantitative difference of patient's CBF from the normative data of an age-matched healthy population (cCBF). Interictal ASL-CBF were acquired in 65 pediatric patients with focal epilepsy: 26 with focal brain lesions and 39 with a normal MRI...
March 25, 2022: Diagnostics
https://read.qxmd.com/read/35451851/multidelay-asl-of-the-pediatric-brain
#22
REVIEW
Xavier Golay, Mai-Lan Ho
Arterial spin labeling (ASL) is a powerful noncontrast MRI technique for evaluation of cerebral blood flow (CBF). A key parameter in single-delay ASL is the choice of postlabel delay (PLD), which refers to the timing between the labeling of arterial free water and measurement of flow into the brain. Multidelay ASL (MDASL) utilizes several PLDs to improve the accuracy of CBF calculations using arterial transit time (ATT) correction. This approach is particularly helpful in situations where ATT is unknown, including young subjects and slow-flow conditions...
April 22, 2022: British Journal of Radiology
https://read.qxmd.com/read/34924466/-mri-arterial-spin-labeling-is-useful-for-diagnosing-recovery-from-nonconvulsive-status-epilepticus-with-sustained-periodic-discharges
#23
JOURNAL ARTICLE
Satoshi Saito, Mutsumi Iijima, Misa Seki, Hiroshi Yoshizawa, Kazuo Kitagawa
A 75-year-old man with a history of temporal lobe epilepsy (treated with levetiracetam) was transferred to our hospital because of loss of consciousness. At admission, he was drowsy and exhibited myoclonus on the left side of face. We established a diagnosis of status epilepticus and started treatment with levetiracetam, fosphenytoin, and midazolam. FLAIR and DWI showed hyperintensity in the right cerebral cortex. Electroencephalography (EEG) showed lateralized periodic discharges (LPDs) at the right hemisphere, indicative of non-convulsive status epilepticus (NCSE)...
December 18, 2021: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/34912017/effects-of-sub-threshold-transcutaneous-auricular-vagus-nerve-stimulation-on-cerebral-blood-flow
#24
JOURNAL ARTICLE
Conan Chen, Yixiang Mao, Maryam Falahpour, Kelly H MacNiven, Gary Heit, Vivek Sharma, Konstantinos Alataris, Thomas T Liu
Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise as a non-invasive alternative to vagus nerve stimulation (VNS) with implantable devices, which has been used to treat drug-resistant epilepsy and treatment-resistant depression. Prior work has used functional MRI to investigate the brain response to taVNS, and more recent work has also demonstrated potential therapeutic effects of high-frequency sub-threshold taVNS in rheumatoid arthritis. However, no studies to date have measured the effects of high-frequency sub-threshold taVNS on cerebral blood flow (CBF)...
December 15, 2021: Scientific Reports
https://read.qxmd.com/read/34728940/role-of-interictal-arterial-spin-labeling-magnetic-resonance-perfusion-in-mesial-temporal-lobe-epilepsy
#25
JOURNAL ARTICLE
Ashima Mittal, Devinder Pal Singh Dhanota, Kavita Saggar, Gagandeep Singh, Archana Ahluwalia
Context: Electrophysiological and hemodynamic data can be integrated to accurately identify the generators of abnormal electrical activity in drug-resistant focal epilepsy. Arterial Spin Labeling (ASL), a magnetic resonance imaging (MRI) technique for quantitative noninvasive measurement of cerebral blood flow (CBF), can provide a direct measure of variations in cerebral perfusion associated with the epileptogenic zone. Aims: 1. To evaluate usefulness of ASL for detecting interictal temporal hypoperfusion to localize the epileptogenic zone in patients of drug resistant mesial temporal lobe epilepsy (MTLE)...
July 2021: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/34717841/noncontrast-pediatric-brain-perfusion-arterial-spin-labeling-and-intravoxel-incoherent-motion
#26
REVIEW
Danny J J Wang, Denis Le Bihan, Ram Krishnamurthy, Mark Smith, Mai-Lan Ho
Noncontrast magnetic resonance imaging techniques for measuring brain perfusion include arterial spin labeling (ASL) and intravoxel incoherent motion (IVIM). These techniques provide noninvasive and repeatable assessment of cerebral blood flow or cerebral blood volume without the need for intravenous contrast. This article discusses the technical aspects of ASL and IVIM with a focus on normal physiologic variations, technical parameters, and artifacts. Multiple pediatric clinical applications are presented, including tumors, stroke, vasculopathy, vascular malformations, epilepsy, migraine, trauma, and inflammation...
November 2021: Magnetic Resonance Imaging Clinics of North America
https://read.qxmd.com/read/34645570/arterial-spin-labelling-qualitative-assessment-in-paediatric-patients-with-mri-negative-epilepsy
#27
JOURNAL ARTICLE
L Pasca, F Sanvito, E Ballante, M Totaro, M Paoletti, A Bergui, C Varesio, E Rognone, V De Giorgis, A Pichiecchio
AIM: To evaluate the usefulness of arterial spin labelling (ASL) qualitative analysis for the localisation of seizure-related perfusion abnormalities in paediatric patients with negative brain magnetic resonance imaging (MRI) epilepsy. MATERIALS AND METHODS: Forty-two patients with a diagnosis of MRI-negative focal or generalised epilepsy, who underwent electroencephalogram (EEG) and MRI with ASL in the interictal phase were included. Perfusion abnormalities were evaluated through a qualitative assessment and then compared to EEG seizure focus...
October 10, 2021: Clinical Radiology
https://read.qxmd.com/read/34466237/a-novel-biallelic-lmnb2-variant-in-a-patient-with-progressive-myoclonus-epilepsy-and-ataxia-a-case-of-laminopathy
#28
Saeed Farajzadeh Valilou, Javad Karimzad Hagh, Mohammad Salimi Asl, Isa Abdi Rad, Masoud Edizadeh, Arash Pooladi
The report of LMNB2-related progressive myoclonus epilepsy and ataxia due to missense homozygous c.473G>T variant.
August 2021: Clinical Case Reports
https://read.qxmd.com/read/34362444/arterial-spin-labeling-for-presurgical-localization-of-refractory-frontal-lobe-epilepsy-in-children
#29
JOURNAL ARTICLE
Jia Zhang, Heng Zhang, Yang Li, Meng Yuan, Jinxiu Zhang, Huan Luo, Zeshan Yao, Jing Gan
BACKGROUND: Epilepsy is one of the most common chronic neurological diseases. Despite the great variety and prevalence of antiepileptic drug treatments, one-third of epilepsies remain drug resistant. The frontal lobe is extensive, and frontal lobe seizures are difficult to locate, which increases the difficulty of the preoperative localization of the epileptogenic zone. CASE PRESENTATION: Two previously healthy girls with refractory frontal lobe epilepsy showed significant perfusion abnormalities in the right frontal lobe using the cerebral blood perfusion (CBF) quantitative analysis system...
August 6, 2021: European Journal of Medical Research
https://read.qxmd.com/read/34251501/network-differences-based-on-arterial-spin-labeling-related-to-anti-seizure-medication-response-in-focal-epilepsy
#30
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Hyung Chan Kim, Kang Min Park
PURPOSE: The aim of this study was to determine whether anti-seizure medication (ASM) response is associated with structural connectivity in diffusion tensor imaging (DTI) or functional co-variance network in arterial spin labeling (ASL) magnetic resonance imaging (MRI) in patients with focal epilepsy. METHODS: In this retrospective study conducted at a tertiary hospital, we enrolled 105 patients with focal epilepsy, of which 64 patients were good ASM responders, and 41 patients were poor ASM responders...
July 12, 2021: Neuroradiology
https://read.qxmd.com/read/34144575/sporadic-and-periodic-interictal-discharges-in-critically-ill-children-seizure-associations-and-time-to-seizure-identification
#31
JOURNAL ARTICLE
Arnold J Sansevere, Melissa L DiBacco, Bo Zhang, Alireza Akhondi-Asl, Mark H Libenson, Robert C Tasker, Phillip L Pearl
PURPOSE: We evaluated interictal discharges (IEDs) as a biomarker for the time to development of electrographic seizures (ES). METHODS: Prospective observational study of 254 critically ill children who underwent continuous electroencephalography (cEEG) monitoring. We excluded neonates and patients with known epilepsy or the sole cEEG indication to characterize events. Interictal discharges included sporadic epileptiform discharges and periodic and rhythmic patterns...
May 5, 2021: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://read.qxmd.com/read/34114065/perfusion-imaging-with-arterial-spin-labeling-asl-mri-predicts-malignant-progression-in-low%C3%A2-grade-who-grade-ii-gliomas
#32
JOURNAL ARTICLE
Christina M Flies, Tom J Snijders, Tom Van Seeters, Marion Smits, Filip Y F De Vos, Jeroen Hendrikse, Jan Willem Dankbaar
PURPOSE: Predicting malignant progression of grade II gliomas would allow for earlier initiation of treatment. The hypothesis for this single-centre, case-control study was that the perfusion signal on ASL-MRI predicts such malignant progression in the following 12 months. METHODS: Consecutive patients with the following criteria were included: ≥ 18 years, grade II glioma (biopsied or resected) and an ASL-MRI 6-12 months prior to malignant progression (cases) or stable disease (controls)...
June 11, 2021: Neuroradiology
https://read.qxmd.com/read/34110654/temporal-lobe-epilepsy-with-or-without-hippocampal-sclerosis-structural-and-functional-connectivity-using-advanced-mri-techniques
#33
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Hyung Chan Kim, Kang Min Park
BACKGROUND AND PURPOSE: The aim of this study was to investigate the differences in structural connectivity based on diffusion tensor imaging (DTI) and functional connectivity based on arterial spin labeling (ASL) MRI between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). METHODS: We enrolled 50 patients with TLE, including 25 patients with HS and 25 patients without HS, who underwent brain MRI, including DTI and ASL. We calculated the network parameters of structural connectivity based on DTI and functional connectivity based on ASL using a graph theoretical analysis...
September 2021: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://read.qxmd.com/read/34062847/evaluation-of-arterial-spin-labeling-mri-comparison-with-15-o-water-pet-on-an-integrated-pet-mr-scanner
#34
JOURNAL ARTICLE
Markus Fahlström, Lieuwe Appel, Eva Kumlien, Torsten Danfors, Mathias Engström, Johan Wikström, Gunnar Antoni, Elna-Marie Larsson, Mark Lubberink
Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBFASL ) and 15 O-water positron emission tomography (PET) (CBFPET ) acquired simultaneously on an integrated 3T PET/MR system. The data comprised ASL and dynamic 15 O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years)...
May 1, 2021: Diagnostics
https://read.qxmd.com/read/34035336/epileptogenic-zone-detection-in-mri-negative-epilepsy-using-adaptive-thresholding-of-arterial-spin-labeling-data
#35
JOURNAL ARTICLE
Martin Gajdoš, Pavel Říha, Martin Kojan, Irena Doležalová, Henk J M M Mutsaerts, Jan Petr, Ivan Rektor
Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images...
May 25, 2021: Scientific Reports
https://read.qxmd.com/read/34014557/adult-onset-diagnosis-of-urea-cycle-disorders-results-of-a-french-cohort-of-71-patients
#36
MULTICENTER STUDY
Ségolène Toquet, Marta Spodenkiewicz, Claire Douillard, François Maillot, Jean-Baptiste Arnoux, Lena Damaj, Sylvie Odent, Caroline Moreau, Isabelle Redonnet-Vernhet, Samir Mesli, Aude Servais, Esther Noel, Sybill Charriere, Vincent Rigalleau, Christian Lavigne, Elsa Kaphan, Agathe Roubertie, Gérard Besson, Adrien Bigot, Amélie Servettaz, Fanny Mochel, Roselyne Garnotel
Urea cycle disorders (UCD) are rare diseases that usually affect neonates or young children. During decompensations, hyperammonemia is neurotoxic, leading to severe symptoms and even coma and death if not treated rapidly. The aim was to describe a cohort of patients with adult onset of UCDs in a multicentric, retrospective and descriptive study of French adult patients with a diagnosis after 16 years of age of UCDs due to a deficiency in one of the 6 enzymes (arginase, ASL, ASS, CPS1, NAGS, OTC) or the two transporters (ORNT1 or citrin)...
September 2021: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/33783670/arterial-spin-labeling-is-a-useful-mri-method-for-presurgical-evaluation-in-mri-negative-focal-epilepsy
#37
JOURNAL ARTICLE
Martin Kojan, Martin Gajdoš, Pavel Říha, Irena Doležalová, Zdeněk Řehák, Ivan Rektor
Arterial spin labeling (ASL) is an MRI technique measuring brain perfusion using magnetically labeled blood as a tracer. The clinical utility of ASL for presurgical evaluation in non-lesional epilepsy as compared with the quantitative analysis of interictal [18 F] fluorodeoxyglucose PET (FDG-PET) was studied. In 10 patients (4 female; median age 29 years) who underwent a complete presurgical evaluation followed by surgical resection, the presurgical FDG-PET and ASL scans were compared with the resection masks using asymmetry index (AI) maps...
March 30, 2021: Brain Topography
https://read.qxmd.com/read/33578071/automatic-seizure-detection-using-orthogonal-matching-pursuit-discrete-wavelet-transform-and-entropy-based-features-of-eeg-signals
#38
JOURNAL ARTICLE
Asghar Zarei, Babak Mohammadzadeh Asl
BACKGROUND AND OBJECTIVE: Epilepsy is a prevalent disorder that affects the central nervous system, causing seizures. In the current study, a novel algorithm is developed using electroencephalographic (EEG) signals for automatic seizure detection from the continuous EEG monitoring data. METHODS: In the proposed methods, the discrete wavelet transform (DWT) and orthogonal matching pursuit (OMP) techniques are used to extract different coefficients from the EEG signals...
February 4, 2021: Computers in Biology and Medicine
https://read.qxmd.com/read/33558811/how-antiepileptics-may-change-the-serum-level-of-vitamin-d-calcium-and-phosphorus-in-children-with-epilepsy
#39
JOURNAL ARTICLE
Sasan Saket, Neda Varasteh, Ali Asghar Halimi Asl, Hedyeh Saneifard
Objective: Studies have shown vitamin (Vit) D deficiency and bone disease in long-term use of antiepileptics, especially in young individuals. This study aimed to determine the relationship between antiepileptic drugs and the level of Vit D, calcium (Ca), and phosphorus (P) in children with epilepsy at the Shohada Hospital from 2016 to 2017. Materials & Methods: In this case-control study, 60 consecutive children with epilepsy at the Shohada Hospital from 2016 to 2017 under treatment with anticonvulsions for more than six months were enrolled as the case group...
2021: Iranian Journal of Child Neurology
https://read.qxmd.com/read/33361483/the-utility-of-arterial-spin-labeling-in-the-presurgical-evaluation-of-poorly-defined-focal-epilepsy-in-children
#40
JOURNAL ARTICLE
Jack Lam, Patricia Tomaszewski, Guillaume Gilbert, Jeremy T Moreau, Marie-Christine Guiot, Steffen Albrecht, Jean-Pierre Farmer, Jeffrey Atkinson, Christine Saint-Martin, Pia Wintermark, Boris Bernhardt, Sylvain Baillet, Roy W R Dudley
OBJECTIVE: The authors sought to assess the utility of arterial spin labeling (ASL) perfusion 3T-MRI for the presurgical evaluation of poorly defined focal epilepsy in pediatric patients. METHODS: Pseudocontinuous ASL perfusion 3T-MRI was performed in 25 consecutive children with poorly defined focal epilepsy. ASL perfusion abnormalities were detected qualitatively by visual inspection and quantitatively by calculating asymmetry index (AI) maps and significant z-score cluster maps based on successfully operated cases...
December 25, 2020: Journal of Neurosurgery. Pediatrics
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