keyword
MENU ▼
Read by QxMD icon Read
search

Asl and epilepsy

keyword
https://www.readbyqxmd.com/read/27872690/the-effects-of-kainic-acid-induced-seizure-on-gene-expression-of-brain-neurotransmitter-receptors-in-mice-using-rt-2-pcr-array
#1
Taghi Naserpour Farivar, Marjan Nassiri-Asl, Pouran Johari, Reza Najafipour, Farid Hajiali
INTRODUCTION: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes in the gene expression of brain neurotransmitter receptors one week after administration of kainic acid in the mouse hippocampus...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27755938/arterial-spin-labeling-perfusion-of-the-brain-emerging-clinical-applications
#2
Sven Haller, Greg Zaharchuk, David L Thomas, Karl-Olof Lovblad, Frederik Barkhof, Xavier Golay
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. In this article, the main labeling techniques, notably pulsed and pseudocontinuous ASL, as well as emerging clinical applications will be reviewed. In dementia, the pattern of hypoperfusion on ASL images closely matches the established patterns of hypometabolism on fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images due to the close coupling of perfusion and metabolism in the brain...
November 2016: Radiology
https://www.readbyqxmd.com/read/27515243/argininosuccinic-acid-lyase-deficiency-missed-by-newborn-screen
#3
Rebecca D Ganetzky, Emma Bedoukian, Matthew A Deardorff, Can Ficicioglu
Argininosuccinic acid lyase (ASL) deficiency, caused by mutations in the ASL gene (OMIM: 608310) is a urea cycle disorder that has pleiotropic presentations. On the mild end, ASL deficiency can manifest as nonspecific neurocognitive abnormalities without readily identifiable signs to differentiate it from other causes of intellectual disability or learning disabilities. Dietary management and arginine supplementation, if initiated early, may ameliorate symptoms.Because of the nonspecific nature of the symptoms and the possibility for therapeutic management, ASL deficiency is part of the recommended uniform screening panel for newborn screening in the USA...
August 12, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27459916/a-case-of-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion-utility-of-arterial-spin-labeling-sequence
#4
Keita Kuya, Shinya Fujii, Fuminori Miyoshi, Koyo Ohno, Yuki Shinohara, Yoshihiro Maegaki, Toshihide Ogawa
A 1-year-old boy was admitted because of febrile status epilepticus (FSE). A secondary cluster of seizures was seen on day 5 after onset, and the patient eventually displayed developmental delay. Conventional magnetic resonance imaging (MRI) showed no abnormal findings on day 1 after onset, but showed reduced diffusion in the subcortical regions of bilateral frontal lobes on day 5 after onset. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was diagnosed. Arterial spin labeling (ASL) revealed reduced cerebral blood flow (CBF) in bilateral frontal lobes on day 1 after onset and showed increased CBF in the corresponding region in the subacute phase...
July 23, 2016: Brain & Development
https://www.readbyqxmd.com/read/27386150/modulation-of-the-expression-of-the-gabaa-receptor-%C3%AE-1-and-%C3%AE-3-subunits-by-pretreatment-with-quercetin-in-the-ka-model-of-epilepsy-in-mice-the-effect-of-quercetin-on-gabaa-receptor-beta-subunits
#5
Sahar Moghbelinejad, Zahra Rashvand, Fatemeh Khodabandehloo, Ghazaleh Mohammadi, Marjan Nassiri-Asl
OBJECTIVES: Quercetin is a flavonoid and an important dietary constituent of fruits and vegetables. In recent years, several pharmacological activities of quercetin, such as its neuroprotective activity and, more specifically, its anti-convulsant effects in animal models of epilepsy, have been reported. This study evaluated the role of quercetin pretreatment on gene expression of γ-amino butyric acid type A (GABAA) receptor beta subunits in kainic acid (KA)-induced seizures in mice. METHODS: The animals were divided into four groups: one saline group, one group in which seizures were induced by using KA (10 mg/kg) without quercetin pretreatment and two groups pretreated with quercetin (50 and 100 mg/kg) prior to seizures being induced by using KA...
June 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/27374369/patterns-of-postictal-cerebral-perfusion-in-idiopathic-generalized-epilepsy-a-multi-delay-multi-parametric-arterial-spin-labelling-perfusion-mri-study
#6
Guangxiang Chen, Du Lei, Jiechuan Ren, Panli Zuo, Xueling Suo, Danny J J Wang, Meiyun Wang, Dong Zhou, Qiyong Gong
The cerebral haemodynamic status of idiopathic generalized epilepsy (IGE) is a very complicated process. Little attention has been paid to cerebral blood flow (CBF) alterations in IGE detected by arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI). However, the selection of an optimal delay time is difficult for single-delay ASL. Multi-delay multi-parametric ASL perfusion MRI overcomes the limitations of single-delay ASL. We applied multi-delay multi-parametric ASL perfusion MRI to investigate the patterns of postictal cerebral perfusion in IGE patients with absence seizures...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27236449/scn1a-gene-sequencing-in-46-turkish-epilepsy-patients-disclosed-12-novel-mutations
#7
Sunay Usluer, Seda Salar, Mutluay Arslan, Uluç Yiş, Bülent Kara, Pınar Tektürk, Betül Baykan, Cihan Meral, Dilşad Türkdoğan, Nerses Bebek, Özlem Yalçın Çapan, Aslı Gündoğdu Eken, S Hande Çağlayan
PURPOSE: The SCN1A gene is one of the most commonly mutated human epilepsy genes associated with a spectrum of phenotypes with variable degrees of severity. Despite over 1200 distinct mutations reported, it is still hard to draw clear genotype-phenotype relationships, since genetic and environmental modifiers contribute to the development of a particular disease caused by an SCN1A mutation. We aimed to initiate mutational screening of the SCN1A gene in Turkey and advance further our understanding of the relationship between the SCN1A sequence alterations and disease phenotypes such as GEFS+, DS and related epileptic encephalopathies...
July 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27222796/cerebral-metabolism-and-perfusion-in-mr-negative-individuals-with-refractory-focal-epilepsy-assessed-by-simultaneous-acquisition-of-18-f-fdg-pet-and-arterial-spin-labeling
#8
Ilaria Boscolo Galazzo, Maria Vittoria Mattoli, Francesca Benedetta Pizzini, Enrico De Vita, Anna Barnes, John S Duncan, Hans Rolf Jäger, Xavier Golay, Jamshed B Bomanji, Matthias Koepp, Ashley M Groves, Francesco Fraioli
The major challenge in pre-surgical epileptic patient evaluation is the correct identification of the seizure onset area, especially in MR-negative patients. In this study, we aimed to: (1) assess the concordance between perfusion, from ASL, and metabolism, from (18)F-FDG, acquired simultaneously on PET/MR; (2) verify the utility of a statistical approach as supportive diagnostic tool for clinical readers. Secondarily, we compared (18)F-FDG PET data from the hybrid PET/MR system with those acquired with PET/CT, with the purpose of validate the reliability of (18)F-FDG PET/MR data...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26737361/feasibility-of-blind-source-separation-methods-for-the-denoising-of-dense-array-eeg
#9
N Taheri, A Kachenoura, K Ansari-Asl, A Karfoul, L Senhadji, L Albera, I Merlet
High-density electroencephalographic recordings have recently been proved to bring useful information during the pre-surgical evaluation of patients suffering from drug-resistant epilepsy. However, these recordings can be particularly obscured by noise and artifacts. This paper focuses on the denoising of dense-array EEG data (e.g. 257 channels) contaminated with muscle artifacts. In this context, we compared the efficiency of several Independent Component Analysis (ICA) methods, namely SOBI, SOBIrob, PICA, InfoMax, two different implementations of FastICA, COM2, ERICA, and SIMBEC, as well as that of Canonical Correlation Analysis (CCA)...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26515648/epileptic-ictal-hyperperfusion-on-arterial-spin-labeling-perfusion-and-diffusion-weighted-magnetic-resonance-images-in-posterior-reversible-encephalopathy-syndrome
#10
Kayo Wakisaka, Takato Morioka, Takafumi Shimogawa, Kei Murao, Yuka Kanazawa, Noriko Hagiwara, Shuji Arakawa
BACKGROUND: The hemodynamic state of the posterior dominant vasogenic edema in posterior reversible encephalopathy syndrome (PRES) is controversial. The aim of this retrospective study was to examine the contribution of epileptic ictal hyperperfusion in patients with PRES using combined magnetic resonance perfusion imaging with arterial spin labeling (ASL) and diffusion-weighted magnetic resonance imaging (MRI). METHODS: A detailed review of chronological MRI findings in 2 patients, including diffusion-weighted imaging (DWI) and ASL, with special reference to clinical and electroencephalographic findings, was performed...
January 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26478131/usefulness-of-arterial-spin-labeling-images-in-periictal-state-diagnosis-of-epilepsy
#11
Keita Matsuura, Masayuki Maeda, Keisuke Okamoto, Tomohiro Araki, Yoichi Miura, Kazuhide Hamada, Kenji Kanamaru, Hidekazu Tomimoto
PURPOSE: Arterial spin-labeling (ASL) perfusion MRI, a noninvasive method of assessing cerebral blood flow, is becoming a diagnostic tool of epilepsy. This study was undertaken to evaluate the diagnostic validity of ASL in patients with status epilepticus (SE) in a periictal state. METHOD: Twenty cases with SE were studied. Patients were imaged at a 3T MRI including ASL and diffusion-weighted imaging (DWI), and were also examined using electroencephalography (EEG)...
December 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26413475/structural-and-physiological-mri-correlates-of-occult-cerebrovascular-disease-in-late-onset-epilepsy
#12
Martha F Hanby, Sarah Al-Bachari, Fadiyah Makin, Rishma Vidyasagar, Laura M Parkes, Hedley C A Emsley
Late-onset epilepsy (LOE), with onset after 50 years of age, is often attributed to underlying occult cerebrovascular disease. LOE is associated with a three-fold increase in subsequent stroke risk, therefore it is important to improve our understanding of pathophysiology. In this exploratory study, we aimed to determine whether established structural magnetic resonance imaging markers and novel physiological imaging markers of occult cerebrovascular disease were more common in patients with LOE than age-matched controls...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26346555/accuracy-of-arterial-spin-labeling-magnetic-resonance-imaging-mri-perfusion-in-detecting-the-epileptogenic-zone-in-patients-with-drug-resistant-neocortical-epilepsy-comparison-with-electrophysiological-data-structural-mri-siscom-and-fdg-pet
#13
A Sierra-Marcos, M Carreño, X Setoain, A López-Rueda, J Aparicio, A Donaire, N Bargalló
BACKGROUND AND PURPOSE: Locating the epileptogenic zone (EZ) in patients with neocortical epilepsy presents major challenges. Our aim was to assess the accuracy of arterial spin labeling (ASL), an emerging non-invasive magnetic resonance imaging (MRI) perfusion technique, to locate the EZ in patients with drug-resistant neocortical epilepsy. METHODS: Twenty-five consecutive patients with neocortical epilepsy referred to our epilepsy unit for pre-surgical evaluation underwent a standardized assessment including video-electroencephalography (EEG) monitoring, structural MRI, subtraction ictal single-photon emission computed tomography co-registered to MRI (SISCOM) and fluorodeoxyglucose positron emission tomography (FDG-PET) studies...
January 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/25946055/patient-specific-detection-of-cerebral-blood-flow-alterations-as-assessed-by-arterial-spin-labeling-in-drug-resistant-epileptic-patients
#14
Ilaria Boscolo Galazzo, Silvia Francesca Storti, Alessandra Del Felice, Francesca Benedetta Pizzini, Chiara Arcaro, Emanuela Formaggio, Roberto Mai, Michael Chappell, Alberto Beltramello, Paolo Manganotti
Electrophysiological and hemodynamic data can be integrated to accurately and precisely identify the generators of abnormal electrical activity in drug-resistant focal epilepsy. Arterial Spin Labeling (ASL), a magnetic resonance imaging (MRI) technique for quantitative noninvasive measurement of cerebral blood flow (CBF), can provide a direct measure of variations in cerebral perfusion associated with the epileptic focus. In this study, we aimed to confirm the ASL diagnostic value in the identification of the epileptogenic zone, as compared to electrical source imaging (ESI) results, and to apply a template-based approach to depict statistically significant CBF alterations...
2015: PloS One
https://www.readbyqxmd.com/read/25454505/arterial-spin-labeling-mri-a-step-forward-in-non-invasive-delineation-of-focal-cortical-dysplasia-in-children
#15
Thomas Blauwblomme, Nathalie Boddaert, Nicole Chémaly, Catherine Chiron, Mélanie Pages, Pascale Varlet, Marie Bourgeois, Nadia Bahi-Buisson, Anna Kaminska, David Grevent, Francis Brunelle, Christian Sainte-Rose, Frédérique Archambaud, Rima Nabbout
The aim was to localize the interictal cerebral perfusion abnormalities of focal cortical dysplasia (FCD) in children with Arterial Spin Labeling MRI (ASL) in a retrospective study of nine consecutive children explored with multimodal investigation during interictal periods. We analyzed brain morphology with a 1.5T MRI and a dedicated protocol for epilepsy. Brain perfusion was quantified with pseudo continuous ASL. Brain metabolism was imaged with (18)FDG-PET in six patients. Microvessel histology was studied in five children who underwent epilepsy surgery with CD34 immunostaining on FCD and control samples...
December 2014: Epilepsy Research
https://www.readbyqxmd.com/read/24857759/lateralization-of-temporal-lobe-epilepsy-using-a-novel-uncertainty-analysis-of-mr-diffusion-in-hippocampus-cingulum-and-fornix-and-hippocampal-volume-and-flair-intensity
#16
Mohammad-Reza Nazem-Zadeh, Jason M Schwalb, Kost V Elisevich, Hassan Bagher-Ebadian, Hajar Hamidian, Ali-Reza Akhondi-Asl, Kourosh Jafari-Khouzani, Hamid Soltanian-Zadeh
PURPOSE: To analyze the utility of a quantitative uncertainty analysis approach for evaluation and comparison of various MRI findings for the lateralization of epileptogenicity in mesial temporal lobe epilepsy (mTLE), including novel diffusion-based analyses. METHODS: We estimated the hemispheric variation uncertainty (HVU) of hippocampal T1 volumetry and FLAIR (Fluid Attenuated Inversion Recovery) intensity. Using diffusion tensor images of 23 nonepileptic subjects, we estimated the HVU levels of mean diffusivity (MD) in the hippocampus, and fractional anisotropy (FA) in the posteroinferior cingulum and crus of fornix...
July 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/23793723/electrode-localization-for-planning-surgical-resection-of-the-epileptogenic-zone-in-pediatric-epilepsy
#17
Vahid Taimouri, Alireza Akhondi-Asl, Xavier Tomas-Fernandez, Jurriaan M Peters, Sanjay P Prabhu, Annapurna Poduri, Masanori Takeoka, Tobias Loddenkemper, Ann Marie R Bergin, Chellamani Harini, Joseph R Madsen, Simon K Warfield
PURPOSE: In planning for a potentially curative resection of the epileptogenic zone in patients with pediatric epilepsy, invasive monitoring with intracranial EEG is often used to localize the seizure onset zone and eloquent cortex. A precise understanding of the location of subdural strip and grid electrodes on the brain surface, and of depth electrodes in the brain in relationship to eloquent areas is expected to facilitate pre-surgical planning. METHODS: We developed a novel algorithm for the alignment of intracranial electrodes, extracted from post-operative CT, with pre-operative MRI...
January 2014: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/23792219/combining-esi-asl-and-pet-for-quantitative-assessment-of-drug-resistant-focal-epilepsy
#18
Silvia Francesca Storti, Ilaria Boscolo Galazzo, Alessandra Del Felice, Francesca Benedetta Pizzini, Chiara Arcaro, Emanuela Formaggio, Roberto Mai, Paolo Manganotti
When localization of the epileptic focus is uncertain, the epileptic activity generator may be more accurately identified with non-invasive imaging techniques which could also serve to guide stereo-electroencephalography (sEEG) electrode implantation. The aim of this study was to assess the diagnostic value of perfusion magnetic resonance imaging with arterial spin labeling (ASL) in the identification of the epileptogenic zone, as compared to the more invasive positron-emission tomography (PET) and other established investigation methods for source imaging of electroencephalography (EEG) data...
November 15, 2014: NeuroImage
https://www.readbyqxmd.com/read/23733322/proposing-a-two-level-stochastic-model-for-epileptic-seizure-genesis
#19
F Shayegh, S Sadri, R Amirfattahi, K Ansari-Asl
By assuming the brain as a multi-stable system, different scenarios have been introduced for transition from normal to epileptic state. But, the path through which this transition occurs is under debate. In this paper a stochastic model for seizure genesis is presented that is consistent with all scenarios: a two-level spontaneous seizure generation model is proposed in which, in its first level the behavior of physiological parameters is modeled with a stochastic process. The focus is on some physiological parameters that are essential in simulating different activities of ElectroEncephaloGram (EEG), i...
February 2014: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/23488163/-clinical-applications-of-arterial-spin-labeling-technique-in-brain-diseases
#20
REVIEW
Li Wang, Gang Zheng, Tiezhu Zhao, Chao Guo, Lin Li, Guangming Lu
Arterial spin labeling (ASL) technique is a kind of perfusion functional magnetic resonance imaging method that is based on endogenous contrast, and it can measure cerebral blood flow (CBF) noninvasively. The ASL technique has advantages of noninvasiveness, simplicity and relatively lower costs so that it is more suitable for longitudinal studies compared with previous perfusion methods, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), CT and the contrast agent based magnetic resonance perfusion imaging...
February 2013: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
keyword
keyword
106407
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"