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https://www.readbyqxmd.com/read/28220472/renal-denervation-for-resistant-hypertension
#1
REVIEW
Giuseppe Coppolino, Anna Pisano, Laura Rivoli, Davide Bolignano
BACKGROUND: Resistant hypertension is highly prevalent among the general hypertensive population and the clinical management of this condition remains problematic. Different approaches, including a more intensified antihypertensive therapy, lifestyle modifications, or both, have largely failed to improve patients' outcomes and to reduce cardiovascular and renal risk. As renal sympathetic hyperactivity is a major driver of resistant hypertension, renal sympathetic ablation (renal denervation) has been recently proposed as a possible therapeutic alternative to treat this condition...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28218736/patterns-of-dairy-food-intake-body-composition-and-markers-of-metabolic-health-in-ireland-results-from-the-national-adult-nutrition-survey
#2
E L Feeney, A O'Sullivan, A P Nugent, B McNulty, J Walton, A Flynn, E R Gibney
BACKGROUND: Studies examining the association between dairy consumption and metabolic health have shown mixed results. This may be due, in part, to the use of different definitions of dairy, and to single types of dairy foods examined in isolation. OBJECTIVE: The objective of the study was to examine associations between dairy food intake and metabolic health, identify patterns of dairy food consumption and determine whether dairy dietary patterns are associated with outcomes of metabolic health, in a cross-sectional survey...
February 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28216282/smoking-cessation-improves-cardiometabolic-risk-in-overweight-and-obese-subjects-treated-with-varenicline-and-dietary-counseling
#3
E Heggen, M Svendsen, S Tonstad
BACKGROUND AND AIM: Weight gain after stopping smoking potentially counteracts improvements in cardiometabolic risks. We investigated changes in metabolic syndrome (MetS) components and homeostasis assessment model insulin resistance (HOMA-IR) in smokers given dietary counseling during their quit attempt. METHODS AND RESULTS: Smokers (≥10 cigarettes/day) with BMI 25-40 kg/m(2) were randomized to a low-carbohydrate or low-fat diet and treated with a standard course of varenicline for 12 weeks...
January 4, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28214881/attenuation-of-low-ambient-temperature-induced-myocardial-hypertrophy-by-atorvastatin-via-promoting-bcl-2-expression
#4
Jing Liang, Kun Yin, Xuefeng Cao, Zhenbo Han, Qi Huang, Lai Zhang, Wenya Ma, Fengzhi Ding, Chongwei Bi, Dan Feng, Zhenwei Pan, Yu Liu
BACKGROUND/AIMS: It is well documented that myocardial hypertrophy is associated with low ambient temperature. Atorvastatin (Atv) has been shown to protect against atherosclerosis, cardiac fibrosis, ischemia/reperfusion injury, etc. In this study, we aim to determine whether atorvastatin is effective in the treatment of myocardial hypertrophy induced by cold exposure and to shed light on underlying mechanism. METHODS: The mice aged 4-week were randomized to Control (Ctl) group (raised at room temperature), Cold group (raised at 3-5ºC) and Atv treatment group (raised at 3-5ºC followed by 10mg/kg/day Atv infusion)...
January 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213997/echocardiographic-correlates-are-associated-with-in-hospital-mortality-in-trauma-and-burn-patients
#5
Duraid Younan, Russell Griffin, Donald Reiff, Jeffrey Richey, Eric Schinnerer, Jean-Francois Pittet, Ahmed Zaky
BACKGROUND: The role of echocardiographic indices of preload and contractility in predicting outcomes is unknown. We report the association of end diastolic area (EDA) and fractional area of change (FAC) with mortality in a cohort of trauma and burn patients. METHODS: Data on 86 patients admitted to a tertiary care center between July 2013 and July 2015 were reviewed. The association between abnormal EDA and FAC and adverse clinical outcomes was tested using exact logistic regression analysis...
February 9, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28210440/analytical-parameters-and-vital-signs-in-patients-subjected-to-dental-extraction
#6
Enric Jané-Pallí, Carlos Arranz-Obispo, Beatriz González-Navarro, Jesús Murat, Raúl Ayuso-Montero, Santiago Rojas, Amparo Santamaría, Enric Jané-Salas, José López-López
BACKGROUND: Dental consultation may provoke stress to the patient, especially when a dental surgery is going to be performed, stressful situations can cause a reaction in the sympathetic nervous system that could lead to cardiovascular alterations. Blood pressure and cardiac frequency are used often as an indirect measurement and this parameters combined can serve as good indicators of stress. Objective: Analyze the changes in vital signs and analytical parameters induced by a dental extraction...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208842/assessment-of-serum-vaspin-levels-among-type-2-diabetes-mellitus-patients-with-or-without-acute-coronary-syndrome
#7
Aswathy Jaya Sathyaseelan, Prashant Shankarrao Adole, Mukta Wyawahare, Rama Prakasha Saya
INTRODUCTION: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Visceral Adipose Tissue Derived Serine Protease Inhibitor (VASPIN); one of the most recently discovered adipokine, inhibits the proteases responsible for insulin resistance, carotid plaque development and rupture. In literature, few studies have addressed the role of VASPIN in pathogenesis of Acute Coronary Syndrome (ACS) in patients with type 2 DM...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207876/circulating-c1q-complement-tnf-related-protein-ctrp-1-ctrp9-ctrp12-and-ctrp13-concentrations-in-type-2-diabetes-mellitus-in-vivo-regulation-by-glucose
#8
Bo Bai, Bo Ban, Zunjing Liu, Man Man Zhang, Bee Kang Tan, Jing Chen
OBJECTIVES: The C1q complement/TNF-related protein (CTRP) superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus (T2DM), with age and BMI matched controls, and to examine the effects of a 2 hour 75g oral glucose tolerance test (OGTT) on serum CTRP1, CTRP9, CTRP12 and CTRP13 levels in persons with T2DM...
2017: PloS One
https://www.readbyqxmd.com/read/28198536/prevalence-of-risk-factors-and-asymptomatic-carotid-atherosclerosis-in-diabetic-patients-screened-for-silent-myocardial-ischemia-by-spect-myocardial-imaging
#9
Irena Peovska Mitevska, Natalija Baneva, Marijan Bosevski, Elizabeta Srbinovska Kostovska
BACKGROUND: The aim of the study was to evaluate whether there is any association between myocardial ischemia, common risk factors and carotid artery ultrasound parameters in asymptomatic type 2 diabetic (DMT2) patients. MATERIAL AND METHODS: 60 asymptomatic DMT2 patients (pts) without known coronary artery disease (CAD) underwent one day rest Dypiridamole stress Tc-99m sestamibi single photon emission computed tomography myocardial perfusion scintigraphy (MPS)...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28195167/handgrip-strength-cutoff-for-cardiometabolic-risk-index-among-colombian-children-and-adolescents-the-fuprecol-study
#10
Robinson Ramírez-Vélez, Jhonatan Camilo Peña-Ibagon, Javier Martínez-Torres, Alejandra Tordecilla-Sanders, Jorge Enrique Correa-Bautista, Felipe Lobelo, Antonio García-Hermoso
Evidence shows an association between muscular strength (MS) and health among young people, however low muscular strength cut points for the detection of high metabolic risk in Latin-American populations are scarce. The aim of this study was twofold: to explore potential age- and sex-specific thresholds of MS, for optimal cardiometabolic risk categorization among Colombian children and adolescents; and to investigate whether cardiometabolic risk differed by MS group by applying the receiver operating characteristic curve (ROC) cut point...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194575/outcome-of-extremely-low-birth-weight-infants-with-a-history-of-neonatal-acute-kidney-injury
#11
Syeda Maqsood, Nicholas Fung, Vikas Chowdhary, Rupesh Raina, Maroun J Mhanna
OBJECTIVE: To study the outcome of extremely low birth weight (ELBW) infants with a history of acute kidney injury (AKI). METHOD: In a retrospective, case control study, medical records of all ELBW infants admitted to the neonatal intensive care unit (NICU) between Jan 2002 and Dec 2011 were reviewed. Medical records were reviewed for infants' demographics, blood pressure (BP) at NICU discharge and at ≥3 years, and estimated glomerular filtration rate (eGFR) at ≥2 years...
February 14, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28191874/instantaneous-wave-free-ratio-to-guide-coronary-revascularization-physiological-framework-validation-and-differences-with-fractional-flow-reserve
#12
Guus A de Waard, Carlo Di Mario, Amir Lerman, Patrick W Serruys, Niels van Royen
Determining the optimal treatment strategy for revascularization of coronary artery stenosis involves the use of fractional flow reserve (FFR). To improve the low clinical uptake of physiological lesion assessment to guide revascularization, the instantaneous wave-free period (iFR) was proposed as a simpler alternative to FFR that does not require adenosine administration. iFR is calculated as the ratio of blood pressure distal and proximal to a coronary artery stenosis during the diastolic wave- free period...
February 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28190578/quarter-dose-quadruple-combination-therapy-for-initial-treatment-of-hypertension-placebo-controlled-crossover-randomised-trial-and-systematic-review
#13
Clara K Chow, Jay Thakkar, Alex Bennett, Graham Hillis, Michael Burke, Tim Usherwood, Kha Vo, Kris Rogers, Emily Atkins, Ruth Webster, Michael Chou, Hakim-Moulay Dehbi, Abdul Salam, Anushka Patel, Bruce Neal, David Peiris, Henry Krum, John Chalmers, Mark Nelson, Christopher M Reid, Mark Woodward, Sarah Hilmer, Simon Thom, Anthony Rodgers
BACKGROUND: Globally, most patients with hypertension are treated with monotherapy, and control rates are poor because monotherapy only reduces blood pressure by around 9/5 mm Hg on average. There is a pressing need for blood pressure-control strategies with improved efficacy and tolerability. We aimed to assess whether ultra-low-dose combination therapy could meet these needs. METHODS: We did a randomised, placebo-controlled, double-blind, crossover trial of a quadpill-a single capsule containing four blood pressure-lowering drugs each at quarter-dose (irbesartan 37·5 mg, amlodipine 1·25 mg, hydrochlorothiazide 6·25 mg, and atenolol 12·5 mg)...
February 9, 2017: Lancet
https://www.readbyqxmd.com/read/28184166/canagliflozin-improves-risk-factors-of-metabolic-syndrome-in-patients-with-type-2-diabetes-mellitus-and-metabolic-syndrome
#14
Michael J Davies, Katherine W Merton, Ujjwala Vijapurkar, Dainius A Balis, Mehul Desai
OBJECTIVE: Metabolic syndrome refers to a collection of risk factors associated with the development of cardiovascular disease and type 2 diabetes mellitus (T2DM). Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves glycemic control and reduces body weight and blood pressure (BP) in a broad range of patients with T2DM. This post hoc analysis assessed the effects of canagliflozin on the components of metabolic syndrome in patients with T2DM and metabolic syndrome. METHODS: This analysis was based on data from 2 head-to-head studies of canagliflozin in patients with T2DM on background metformin versus glimepiride (study 1) and background metformin plus sulfonylurea versus sitagliptin 100 mg (study 2)...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28182575/response-of-a-physiological-controller-for-ventricular-assist-devices-during-acute-patho-physiological-events-an-in-vitro-study
#15
Anastasios Petrou, Panagiotis Pergantis, Gregor Ochsner, Raffael Amacher, Thomas Krabatsch, Volkmar Falk, Mirko Meboldt, Marianne Schmid Daners
The current paper analyzes the performance of a physiological controller for turbodynamic ventricular assist devices (tVADs) during acute patho-physiological events. The numerical model of the human blood circulation implemented on our hybrid mock circulation was extended in order to simulate the Valsalva maneuver (VM) and premature ventricular contractions (PVCs). The performance of an end-diastolic volume (EDV)-based physiological controller for VADs, named preload responsive speed (PRS) controller was evaluated under VM and PVCs...
February 9, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28182044/efficacy-and-safety-of-early-tacrolimus-conversion-to-sirolimus-after-kidney-transplantation-long-term-results-of-a-prospective-randomized-study
#16
A E El-Agroudy, S M Alarrayed, S M Al-Ghareeb, E Farid, H Alhelow, S Abdulla
We report a prospective, open-label, randomized study to evaluate the safety and efficacy of converting patients with a stable renal function from tacrolimus (Tac)-based regimen to a sirolimus (SRL)-based regimen after kidney transplantation. Fifty-eight low-risk renal allograft recipients who receiving Tac 6 months posttransplant, were randomly assigned to continue Tac (n = 29) or convert to SRL (n = 29). We evaluated the 3-year outcomes including patient and graft survival, graft function, and safety profile...
January 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28180122/acute-kidney-injury-risk-factors-for-icu-patients-following-cardiac-surgery-the-application-of-joint-modeling
#17
Batoul Khoundabi, Anoshirvan Kazemnejad, Marjan Mansourian, Seyed Mohammadreza Hashemian, Mehdi Kazempoor Dizaji
BACKGROUND: Admission to the ICU (intensive care unit) is frequently complicated by early AKI (acute kidney injury). The development of AKI following cardiac surgery is particularly associated with increased mortality and morbidity. According to AKIN (acute kidney injury network) criteria, UO (urinary output) is a predictor for AKI. OBJECTIVES: The goal of this study was to determine the effects of some AKI risk factors on AKI and also to investigate changes in UO as a predictor of AKI using joint modeling...
September 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28179965/primary-care-based-investigation-of-the-effect-of-sitagliptin-on-blood-pressure-in-hypertensive-patients-with-type-2-diabetes
#18
Shouhei Yuasa, Kazuyoshi Sato, Takamoto Furuki, Kosuke Minamizawa, Hiroyuki Sakai, Yuichi Numata, Keiichi Chin, Jisho Kojima, Masaaki Miyakawa, Ikuro Matsuba
BACKGROUND: The influence of long-term sitagliptin therapy on office blood pressure (BP) and home BP has been unclear. METHODS: In a retrospective cohort study of 454 patients with type 2 diabetes, the following variables were analyzed before and at 3, 6, 9, and 12 months after initiation of sitagliptin therapy: office systolic blood pressure (SBP), office diastolic blood pressure (DBP), office pulse rate, morning home SBP, morning home DBP, morning home pulse rate, evening home SBP, evening home DBP, evening home pulse rate, hemoglobin A1c (HbA1c), plasma glucose, lipid profile, and renal function parameters...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28174436/cardiovascular-response-to-bouts-of-exercise-with-blood-flow-restriction
#19
Kestutis Bunevicius, Arturas Sujeta, Kristina Poderiene, Birute Zachariene, Viktoras Silinskas, Rimantas Minkevicius, Jonas Poderys
[Purpose] Occlusion training with low-intensity resistance exercises and blood flow restriction increases muscle cross-sectional area and strength. This form of training is used in rehabilitation; therefore, the aim of this study was to examine the effect of one occlusion training session on the cardiovascular response to bouts of exercise. [Subjects and Methods] Two groups took part: a control group without blood flow restriction and an experimental group with blood flow restriction. A single training session was used with the exercise intensity set at 40% of the one repetition maximum...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28173786/a-randomized-controlled-trial-of-the-effect-of-yoga-and-peer-support-on-glycaemic-outcomes-in-women-with-type-2-diabetes-mellitus-a-feasibility-study
#20
RANDOMIZED CONTROLLED TRIAL
Aswathy Sreedevi, Unnikrishnan Ambika Gopalakrishnan, Sundaram Karimassery Ramaiyer, Leelamoni Kamalamma
BACKGROUND: Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio among the people with diabetes is roughly equal, women are uniquely and more severely affected. Management of type two Diabetes requires considerable dexterity on the part of the patient to manage drugs, diet and exercise. Therefore, in a low middle-income country like India it is necessary to look at low cost interventions that can empower the patient and build on available resources to help manage diabetes...
February 7, 2017: BMC Complementary and Alternative Medicine
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