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Psoriasis

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https://www.readbyqxmd.com/read/29027743/generalized-pustular-psoriasis-triggered-by-zika-virus-infection
#1
A E Paniz Mondolfi, M Hernandez Perez, G Blohm, M Marquez, A Mogollon Mendoza, C E Hernandez-Pereira, M A Escalona, A Lodeiro Colatosti, J Rothe DeArocha, A J Rodriguez Morales
Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Based on recent experimental data on the biology of ZIKV infection in the cutaneous environment, we speculate that ZIKV may have directly triggered the development of generalized pustular psoriasis by stimulation of keratinocyte-derived mediators of inflammation and a polyfunctional T-cell driven immune reaction in the cutaneous milieu...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29027583/changes-in-circulating-cell-free-dna-and-nucleosomes-in-patients-with-exacerbated-psoriasis
#2
Martin Beranek, Zdenek Fiala, Jan Kremlacek, Ctirad Andrys, Jan Krejsek, Kvetoslava Hamakova, Marcela Chmelarova, Vladimir Palicka, Lenka Borska
Psoriasis is a multifactorial chronic inflammatory disease. We aimed to examine blood levels of nucleosomes derived from apoptotic cells, nucleosomal cell-free DNA (cfDNA) and immune-inflammatory biomarkers tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin 6 (IL-6) in psoriatic subjects. The study included 28 patients with exacerbated psoriasis vulgaris and 22 controls. The clinical and laboratory investigations included the determination of PASI score, BMI, cfDNA (by real-time PCR), nucleosomes, TNF-α, CRP, and IL-6...
October 13, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29023827/tnf%C3%AE-and-il-17a-are-differentially-expressed-in-psoriasis-like-vs-eczema-like-drug-reactions-to-tnf%C3%AE-antagonists
#3
C Deubelbeiss, A G A Kolios, L E French, N Yawalkar, W Kempf, K Kerl, B Meier, F Anzengruber, A A Navarini
BACKGROUND: Tumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema-like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. The exact pathophysiology is as yet unknown. METHODS: 33 patients (19 female, average age 52 years) who had a cutaneous reaction to infliximab, adalimumab or etanercept were included...
October 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29022560/topical-therapy-of-psoriasis-where-do-we-stand
#4
D M Thappa, M Malathi
No abstract text is available yet for this article.
October 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29022425/biologics-in-pediatric-psoriasis-efficacy-and-safety
#5
Sunil Dogra, Rahul Mahajan
Introduction Childhood psoriasis is a special situation that is a management challenge for the treating dermatologist. As is the situation with traditional systemic agents, which are commonly used in managing severe psoriasis in children, the biologics are being increasingly used in the recalcitrant disease despite limited data on long term safety. Areas covered - We performed an extensive literature search to collect evidence-based data on the use of biologics in pediatric psoriasis. The relevant literature published from 2000 to September 2017 was obtained from PubMed, using the MeSH words 'biologics', 'biologic response modifiers' or 'treatment of pediatric/childhood psoriasis'...
October 12, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29021166/an-analysis-of-il-36-signature-genes-and-individuals-with-il1rl2-knockout-mutations-validates-il-36-as-a-psoriasis-therapeutic-target
#6
Satveer K Mahil, Marika Catapano, Paola Di Meglio, Nick Dand, Helena Ahlfors, Ian M Carr, Catherine H Smith, Richard C Trembath, Mark Peakman, John Wright, Francesca D Ciccarelli, Jonathan N Barker, Francesca Capon
Interleukin (IL)-36α, IL-36β, and IL-36γ are innate mediators of acute epithelial inflammation. We sought to demonstrate that these cytokines are also required for the pathogenesis of plaque psoriasis, a common and chronic skin disorder, caused by abnormal T helper 17 (TH17) cell activation. To investigate this possibility, we first defined the genes that are induced by IL-36 cytokines in primary human keratinocytes. This enabled us to demonstrate a significant IL-36 signature among the transcripts that are up-regulated in plaque psoriasis and the susceptibility loci associated with the disease in genome-wide studies...
October 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29020033/genotype-combination-contributes-to-psoriasis-an-exhaustive-algorithm-perspective
#7
Jinfa Dou, Huimin Guo, Fang Cheng, Hequn Huang, Liying Fu, Longnian Li, Chao Yang, Lei Ye, Leilei Wen, Yuyan Cheng, Lili Tang, Caihong Zhu, Zhengwei Zhu, Wenjun Wang, Yujun Sheng, Zaixing Wang, Shengxiu Liu, Xing Fan, Xianbo Zuo, Fusheng Zhou, Liangdan Sun, Xiaodong Zheng, Xuejun Zhang
Researchers have learned that nearly all conditions and diseases have a genetic component. With the benefit of technological advances, many single-nucleotide polymorphisms (SNPs) have been found to be associated with the risk of complex disorders by using genome wide association studies (GWASs). Disease-associated SNPs are sometimes shared by healthy controls and cannot clearly distinguish affected individuals from unaffected ones. The combined effects of multiple independent SNPs contribute to the disease process, but revealing the relationship between genotype and phenotype based on the combinations remains a great challenge...
2017: PloS One
https://www.readbyqxmd.com/read/29019882/koebner-phenomenon-induced-by-failed-revisional-orthopedic-surgery-but-remitted-with-bone-union-a-case-report
#8
Yiing-Feng Hwang, Nai-Yuan Wu, Pei-Yuan Lee
RATIONALE: Trauma or surgical incision might cause Koebner phenomenon (KP) in patients with cutaneous diseases, but seldom studies reported KP induced by repeated orthopedic surgery. PATIENT CONCERNS: The 22-year-old man did not have any prior histories of cutaneous diseases. Two months after the revision surgery for nonunion of the left femoral shaft fracture, KP was noted by psoriasis presented at the surgical scar, left thigh, scalp, and trunk. Phototherapy and topical treatments were prescribed but the effect was limited...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019640/spine-conditions-mechanical-and-inflammatory-low-back-pain
#9
Christopher Ledford
Mechanical low back pain (LBP) is an injury or derangement of an anatomic structure in the low back. When evaluating patients with LBP, clinicians should maintain clinical suspicion for vertebral fracture, cancer, and cauda equina syndrome. Management includes patient education focused on exercise, massage, and behavioral approaches such as cognitive behavioral therapy. Acupuncture can be an effective alternative and specific herbal supplements may provide short-term pain relief. The prognosis for patients with mechanical LBP is good...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/29018877/correction-to-digestive-system-in-psoriasis-an-update
#10
Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich
In the original publication, the data labels are incorrect in Fig. 3. The corrected Fig. 3 is given here.
October 10, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29017843/short-term-reasons-for-withdrawal-and-adverse-events-associated-with-apremilast-therapy-for-psoriasis-in-real-world-practice-compared-to-clinical-trials-a-multicenter-retrospective-study
#11
Arvin Ighani, Jorge R Georgakopoulos, Neil H Shear, Scott Walsh, Jensen Yeung
No abstract text is available yet for this article.
October 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29017738/the-burden-of-atopic-dermatitis-in-us-adults-health-care-resource-utilization-data-from-the-2013-national-health-and-wellness-survey
#12
Laurent Eckert, Shaloo Gupta, Caroline Amand, Abhijit Gadkari, Puneet Mahajan, Joel M Gelfand
BACKGROUND: There is a lack of data on the burden of atopic dermatitis (AD) in adults relative to the general population. OBJECTIVE: To characterize the AD burden in adult patients relative to both matched non-AD controls and matched patients with psoriasis in terms of comorbidities, health care resource utilization (HCRU), and costs. METHODS: Adults (≥18 years) who self-reported a diagnosis of AD or psoriasis and adult non-AD controls were identified from the 2013 US National Health and Wellness Survey...
October 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29017591/residual-disease-activity-and-treatment-adjustments-in-psoriatic-arthritis-in-current-clinical-practice
#13
Leonieke J J van Mens, Marleen G H van de Sande, Inka A Fluri, Sadaf Atiqi, Arno W R van Kuijk, Dominique L P Baeten
BACKGROUND: With expanding therapeutic possibilities for treatment of psoriatic arthritis (PsA) it will be increasingly important to determine residual disease and define when to adjust treatment. The rationale behind treatment decisions in current daily clinical practice and the relationship with residual disease activity has not been investigated. The aim of this study was to assess current clinical practice on defining residual disease and subsequent treatment decisions made in PsA patients...
October 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29016537/long-pulsed-nd-yag-laser-treatment-for-nail-psoriasis
#14
Selda Pelin Kartal, Filiz Canpolat, Muzeyyen Gonul, Can Ergin, Zeynep Gencturk
BACKGROUND: Psoriasis is a chronic inflammatory skin disease in which lesions display angiogenesis and increased vascularity. OBJECTIVE: The long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treats vascular lesions which suggests that it might also be used to treat nail psoriasis. METHODS: Sixteen patients (10 males and 6 females) with isolated nail psoriasis or nail with only mild cutaneous involvement were enrolled in the study...
October 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28994166/newer-treatments-of-psoriasis-regarding-il-23-inhibitors-phosphodiesterase-4-inhibitors-and-janus-kinase-inhibitors
#15
REVIEW
Dominika Wcisło-Dziadecka, Martyna Zbiciak-Nylec, Ligia Brzezińska-Wcisło, Katarzyna Bebenek, Agata Kaźmierczak
The rapid progress of genetic engineering furthermore opens up new prospects in the therapy of this difficult-to-treat disease. IL-23 inhibitors, phosphodiesterase 4 (PDE4) inhibitors, and Janus kinase (JAK) inhibitors are currently encouraging further research. Two drugs which are IL-23 inhibitors are now in phase III of clinical trials. The aim of the action of both drugs is selective IL-23 inhibition by targeting the p19 subunit. Guselkumab is a fully human monoclonal antibody. Tildrakizumab is a humanized monoclonal antibody, which also belongs to IgG class and is targeted to subunit p19 of interleukin 23 (IL-23)...
October 10, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28994020/vitamin-d-and-the-skin-an-update-for-dermatologists
#16
REVIEW
Elio Kechichian, Khaled Ezzedine
Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this category of patients at risk for vitamin D deficiency...
October 9, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28993993/a-practical-guide-about-tattooing-in-patients-with-chronic-skin-disorders-and-other-medical-conditions
#17
Nicolas Kluger, Christa De Cuyper
With tattoos becoming increasingly mainstream, dermatologists are more and more often consulted by patients who are considering getting an ornamental, cosmetic, or even a medical tattoo, and who subsequently ask for advice. This includes not only patients with chronic skin diseases such as psoriasis or atopic dermatitis but also patients with other medical conditions. This review first explores the reasons why patients may want to get a tattoo and aims to offer some key information to dermatologists on what they should know about tattooing and the main risks associated with this procedure...
October 9, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28993983/skin-manifestations-associated-with-autoimmune-liver-diseases-a-systematic-review
#18
REVIEW
Benedetta Terziroli Beretta-Piccoli, Pietro Invernizzi, M Eric Gershwin, Carlo Mainetti
Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. The association of autoimmune hepatitis with vitiligo is well known, with a particular striking association with type 2 autoimmune hepatitis, a condition occurring almost entirely in children and adolescents, much rarer and more aggressive than type 1 autoimmune hepatitis; probable associations are also identified with alopecia areata, psoriasis, and pyoderma gangrenosum...
October 9, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28993534/teaching-neuroimages-interferon-induced-psoriasis-flare-in-a-multiple-sclerosis-case-remits-with-dimethyl-fumarate
#19
Georgios Tsivgoulis, Georgios N Papadimitropoulos, Aristeidis H Katsanos, Christina Zompola, Apostolos Safouris, Odysseas Kargiotis, Konstantinos Voumvourakis
No abstract text is available yet for this article.
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/28993007/poor-early-response-to-methotrexate-portends-inadequate-long-term-outcomes-in-patients-with-moderate-to-severe-psoriasis-evidence-from-2-phase-3-clinical-trials
#20
Kenneth B Gordon, Keith A Betts, Murali Sundaram, James E Signorovitch, Junlong Li, Meng Xie, Eric Q Wu, Martin M Okun
BACKGROUND: Most methotrexate-treated psoriasis patients do not achieve a long-term PASI75 (75% reduction from baseline Psoriasis Area and Severity Index score) response. Indications of nonresponse can be apparent after only 4 weeks of treatment. OBJECTIVE: To develop a prediction rule to identify patients unlikely to respond adequately to methotrexate. METHODS: Patient-level data from CHAMPION (NCT00235820, N = 110) was used to construct a prediction model for week 16 PASI75 by using patient baseline characteristics and week 4 PASI25...
October 6, 2017: Journal of the American Academy of Dermatology
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