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Psoriasis

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https://www.readbyqxmd.com/read/29224240/phototherapy-in-france-quantitative-data-2007-2016-from-the-national-health-insurance-register
#1
François Aubin, Jocelyn Courtois, Eve Puzenat, Charlée Nardin, Florence Castelain, Fabien Pelletier, Christelle Gastaldi-Ménager
Phototherapy is a cost-effective treatment with a safe side-effect profile for the management of a wide range of dermatoses. Although one of the most common indications for phototherapy is psoriasis, the use of phototherapy for psoriasis has seen a decline in the U.S.A. Data from the National Ambulatory Medical Care Survey indicate a 94% decrease of physician visits for phototherapy between 1994 and 1998. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224199/paradoxical-psoriasiform-reactions-of-anti-tumour-necrosis-factor-therapy-in-inflammatory-bowel-disease-patients
#2
Faseeha C Peer, Andrew Miller, Paul Pavli, Kavitha Subramaniam
Anti-tumour necrosis factor (TNF) agents have demonstrated efficacy in inflammatory bowel disease (IBD). Cutaneous reactions such as new onset psoriasis or psoriasiform-like reactions are among the most common adverse reactions. We retrospectively identified cases of anti-TNF-induced psoriasis or psoriasiform manifestations in IBD patients at a tertiary centre in Australia. A total of 10 (six females) of 270 (3.7%) IBD patients treated with anti-TNF therapy developed drug-induced psoriatic or psoriasiform-like reactions: five patients were treated with infliximab and five with adalimumab; nine had Crohn disease...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29222947/safety-and-efficacy-of-guselkumab-in-japanese-patients-with-moderate-to-severe-plaque-psoriasis-a-randomised-placebo-controlled-ascending-dose-study
#3
O Nemoto, K Hirose, S Shibata, K Li, H Kubo
BACKGROUND: The Interlukin-23 (IL-23)/Interlukin-17 (IL-17) pathway is central in the pathogenesis of psoriasis. The favourable efficacy and safety of guselkumab, an IL-23 specific monoclonal antibody, has been demonstrated in global Phase 3 studies of plaque psoriasis. OBJECTIVES: To evaluate the safety, efficacy and pharmacokinetics of a single-dose subcutaneous guselkumab in Japanese patients with moderate-to-severe plaque psoriasis. METHODS: Patients with ≥ 10% of total body surface area (BSA) involvement and a Psoriasis Area and Severity Index (PASI) ≥12 were randomised (5:1) to receive guselkumab or placebo in 4 cohorts of this double-blind, placebo-controlled, single ascending dose, single-centre study...
December 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29222824/elevated-levels-of-the-antimicrobial-peptide-ll-37-in-hidradenitis-suppurativa-are-associated-with-a-th1-th17-immune-response
#4
R Thomi, C Schlapbach, N Yawalkar, D Simon, D Yerly, R E Hunger
Hidradenitis suppurativa (HS) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL-37 is an antimicrobial peptide, which is transcribed from the CAMP (cathelicidin antimicrobial peptide) gene. Previous reports showed upregulated levels of CAMP and LL-37 in HS lesions and therefore the aim of this study was to compare levels of LL-37 in HS to other inflammatory skin diseases and to establish immunomodulatory functions of LL-37 in HS. We confirm an upregulation of the LL-37 peptide in lesional HS skin with comparable levels as in psoriasis patients and are able to positively correlate the presence of LL-37 in HS with the presence of T cells, macrophages, neutrophils, IFNγ, IL-17, IL-23, TNFα, IL-32 and IL-1β...
December 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29221177/untargeted-serum-metabonomics-study-of-psoriasis-vulgaris-based-on-ultra-performance-liquid-chromatography-coupled-to-mass-spectrometry
#5
Li Li, Lu Chuan-Jian, Han Ling, Deng Jing-Wen, He Ze-Hui, Yan Yu-Hong, Zhang Zhong-Zhao
Psoriasis is a common, chronic, systemic inflammatory skin disease, the etiology and pathogenesis is unclear. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrometry was applied to study the serum metabolic changes in psoriasis vulgaris patients, and to discover serum potential biomarkers for identification, diagnosis and exploring pathogenesis of psoriasis. The serum metabolic profiles from 150 subjects (75 psoriasis patients and 75 healthy controls) were acquired, the raw spectrometric data were processed by multivariate statistical analysis, and 44 potential biomarkers were screened out and identified...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221136/kif3a-and-il-4-are-disease-specific-biomarkers-for-psoriatic-arthritis-susceptibility
#6
Raffaella Cascella, Claudia Strafella, Michele Ragazzo, Laura Manzo, Gaetana Costanza, John Bowes, Ulrike Hüffmeier, Saverio Potenza, Federica Sangiuolo, André Reis, Anne Barton, Giuseppe Novelli, Augusto Orlandi, Emiliano Giardina
To date, the genes associated with Psoriatic Arthritis (PsA) are principally involved in inflammation, immune response and epidermal differentiation, without any information about the relationship between disease and bone metabolism genes. Our work was focused on 5q31 locus, which contains several genetic variants significantly associated with PsA. The study involved 1526 subjects (500 PsA, 426 PsV, 600 controls). The region was evaluated by selecting and genotyping the SNPs of interest by Real Time PCR and direct sequencing...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220875/interleukin-21-receptor-signaling-is-not-critically-required-for-imiquimod-induced-psoriasiform-dermatitis-in-mice
#7
Hee Joo Kim, Sung Hee Kim, Tae-Gyun Kim, Je Yun Park, Minseok Lee, Dae Suk Kim, Min-Geol Lee
Psoriasis is largely mediated by interleukin (IL)-23/ T helper (Th) 17 axis, and IL-21 is a pleiotropic cytokine expressed by Th17 cells. Despite previously reported possible pathogenic roles of IL-21 in human psoriasis, we found that IL-21 receptor (IL-21R) signaling was not crucial for imiquimod-induced psoriatic inflammation, using IL-21R-/- mice. The severity of imiquimod-induced psoriatic manifestation and pro-inflammatory Th17 cytokine levels, IL-17A-producing γδ T cells and CD4+ T cells, and in vitro IL-17A production by γδ T cells after IL-23 stimulation was comparable between wild-type and IL-21R-/- mice...
December 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29220551/consensus-on-the-management-of-patients-with-psoriatic-arthritis-in-a-dermatology-setting
#8
P Gisondi, G Altomare, F Ayala, A Conti, P Dapavo, C De Simone, C Foti, L Idolazzi, E Lubrano, G Malara, A Marchesoni, I Olivieri, A Parodi, K Peris, S Piaserico, C Salvarani, R Scarpa, G Girolomoni
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis (PsO). Early diagnosis and prompt therapeutic intervention are crucial for limiting PsA progression and prevention of disability. Dermatologists are in a privileged position to detect early PsA. The management of patients with PsA in the dermatology setting is widely variable. OBJECTIVE: To provide practical recommendations for the management of patients with PsA in the dermatology setting including early diagnosis and treatment...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29220542/safety-and-efficacy-of-apremilast-through-104-weeks-in-patients-with-moderate-to-severe-psoriasis-who-continued-on-apremilast-or-switched-from-etanercept-treatment-findings-from-the-liberate-study
#9
K Reich, M Gooderham, A Bewley, L Green, J Soung, R Petric, J Marcsisin, J Cirulli, R Chen, V Piguet
BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, has demonstrated efficacy in patients with moderate to severe psoriasis. OBJECTIVE: To evaluate long-term efficacy and safety of apremilast in biologic-naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID, or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase)...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29220417/a-major-win-for-the-treatment-of-nail-psoriasis
#10
Shari R Lipner
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August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29218492/efficacy-of-secukinumab-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-in-the-north-american-subgroup-of-patients-pooled-analysis-of-four-phase-3-studies
#11
David Pariser, Ellen Frankel, Joel Schlessinger, Yves Poulin, Ronald Vender, Richard G Langley, Xiangyi Meng, Adriana Guana, Judit Nyirady
INTRODUCTION: Demographic and disease characteristics may impact response to psoriasis therapies. The objective of this study is to explore the safety and efficacy profile of secukinumab in North American (NA) versus non-NA patients with moderate to severe psoriasis. METHODS: Data were pooled from four phase 3 studies of secukinumab. Secukinumab (300 and 150 mg) was administered at baseline, weeks 1, 2, and 3, then every 4 weeks from week 4 to 48. RESULTS: Peak efficacy was observed at week 16 in NA and non-NA patients with secukinumab 300 mg and secukinumab 150 mg, and disease clearance was maintained to week 52...
December 7, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29216277/immune-mediated-inflammatory-diseases-differently-affect-igras-accuracy-for-latent-tuberculosis-infection-diagnosis-in-clinical-practice
#12
Irene Latorre, Sonia Mínguez, José-Manuel Carrascosa, Juan Naves, Raquel Villar-Hernández, Beatriz Muriel, Cristina Prat, Esther García-García, Irma Casas, Eugeni Domènech, Carlos Ferrándiz, Lourdes Mateo, Jose Domínguez
BACKGROUND: Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB accuracy. METHODS: Patients with IMIDs who required latent tuberculosis infection (LTBI) screening were enrolled and classified into: (i) 50 patients with inflammatory rheumatic diseases, (ii) 50 patients with psoriasis and (iii) 30 patients with Crohn's disease...
2017: PloS One
https://www.readbyqxmd.com/read/29215183/use-of-biological-drugs-in-patients-with-psoriasis-and-psoriatic-arthritis-in-italy-results-from-the-psong-survey
#13
Maria C Potenza, Ketty Peris, Enzo Berardesca, Luca Bianchi, Antonio Richetta, Nicoletta Bernardini, Clara De Simone, Miriam Teoli, Arianna Zangrilli, Sara D'epiro, Diego Orsini, Alessandra Narcisi, Sergio Chimenti, Antonio Costanzo
This Italian multicenter retrospective study compared the drug survival and efficacy of different anti-TNF agents in psoriasis (PsO) and psoriatic arthritis (PsA) patients. A database of PsO/PsA patients treated with adalimumab, etanercept, and infliximab from May 2013 to May 2014 was analyzed. PASI 75, 90, and 100 was calculated at each time point to evaluate efficacy. Drug survival rate and probability of maintaining PASI response were evaluated. The impact of dependent variables on probability of PASI 75 loss was evaluated by logistic regression...
December 7, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29215143/generalized-pustular-psoriasis-in-a-92-year-old-man-with-a-homozygous-nonsense-mutation-in-il36rn
#14
Yoshitaka Ueda, Mayumi Komine, Koji Kamiya, Hidetoshi Tsuda, Takeo Maekawa, Satoru Murata, Mamitaro Ohtsuki
A 92-year-old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP). Genomic DNA was extracted from his peripheral blood and the sequence of IL36RN gene was analyzed, which revealed a p.Arg10X homozygous mutation. Several cases of elderly-onset GPP have been reported, however, this is the oldest case of GPP...
December 7, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29214695/psoriasis-improvement-after-gastric-bandage-in-a-patient-partial-responder-to-infliximab
#15
Giulia Odorici, Andrea Conti
Patients overweight or obese have more severe psoriasis than normal weight patients. Sometimes the excessive weight is related to a lack of efficacy of systemic treatment. We report a case of a psoriatic patient that experienced a dramatic improvement of psoriasis after weight loss surgery by gastric bandage. The great weight loss was accompanied by an effectiveness gain of response to infliximab. The mechanism responsible for this association is not certain, but it is probably multifactorial, involving genetic, environmental and immune-mediated factors...
December 7, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29212353/psoriasis-and-cardiovascular-risk-correlation-between-psoriasis-and-cardiovascular-functional-indices
#16
Giuseppe Dattilo, Egidio Imbalzano, Matteo Casale, Claudio Guarneri, Francesco Borgia, Stefania Mondello, Pasqualina Laganà, Pietro Romano, Giuseppe Oreto, Sarafinella Cannavò
Evidence suggests that psoriasis together with other cardiovascular (CV) risk factors is associated with increased vascular morbidity, but it is not clear whether psoriasis is an independent risk factor. Consecutive patients (n = 33; 35.6 ± 5.7 years; 13 females) with mild psoriasis (Psoriasis Area and Severity Index <10) without comorbidities and 33 healthy participants (36.3 ± 5.9 years; 15 females) were enrolled. Both groups underwent echocardiography, speckle tracking (2-dimensional strain echocardiography [2D-SE]), and pulse wave velocity (PWV) testing...
January 2018: Angiology
https://www.readbyqxmd.com/read/29210087/methotrexate-use-in-allergic-contact-dermatitis-a-retrospective-study
#17
Ashaki Patel, Erin Burns, Nicole M Burkemper
BACKGROUND: Methotrexate, a folate antimetabolite, is used to treat atopic dermatitis and psoriasis. Although methotrexate's therapeutic efficacy has been noted in the literature, there are few data on the efficacy of methotrexate treatment for allergic contact dermatitis. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in treating allergic contact dermatitis at a single institution, and also to assess methotrexate efficacy in patients with chronic, unavoidable allergen exposure...
December 6, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29209945/psoriasis-in-skin-of-color-insights-into-the-epidemiology-clinical-presentation-genetics-quality-of-life-impact-and-treatment-of-psoriasis-in-non-white-racial-ethnic-groups
#18
REVIEW
Bridget P Kaufman, Andrew F Alexis
Psoriasis is a chronic inflammatory skin condition affecting diverse racial/ethnic groups throughout the world. Large population-based studies suggest that psoriasis occurs most often in individuals of European ancestry, followed by black and Hispanic individuals, although the true prevalence of psoriasis in non-white individuals is likely underestimated. Despite similarities in psoriasis between ethnic groups, there are notable differences in the presentation, quality-of-life impact, and treatment of psoriasis with important implications for the management of non-white individuals...
December 5, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29208790/oral-manifestation-in-patients-diagnosed-with-dermatological-diseases
#19
Sanjay G Thete, Meena Kulkarni, Atul P Nikam, Tejashree Mantri, Dhiraj Umbare, Sushant Satdive, Dinraj Kulkarni
AIM: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India. MATERIALS AND METHODS: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29207715/a-correlative-study-between-platelet-count-mean-platelet-volume-and-red-cell-distribution-width-with-the-disease-severity-index-in-psoriasis-patients
#20
Vijayashree Raghavan, Rajesh Kanna Nandagopal Radha, Ramesh K Rao, Abinaya Kuberan
Introduction: Platelet activation is presumed to play an important role in the immunoinflammatory reactions. Several recent studies on a variety of inflammatory disorders have used Mean Platelet Volume (MPV) as a marker for platelet activation. Aim: To determine the relationship between haematological parameters and disease severity index in psoriasis patients. Materials and Methods: A Case control study was carried out on 50 psoriatic patients and 50 healthy control subjects...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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