Jiayi Lv, Yilun Wu, Zhicheng Cao, Xu Liu, Yuzhi Sun, Po Zhang, Xin Zhang, Kexin Tang, Min Cheng, Qingqiang Yao, Yishen Zhu
A carbon nanotube-doped octapeptide self-assembled hydrogel (FEK/C) and a hydrogel-based polycaprolactone PCL composite scaffold (FEK/C3 -S) were developed for cartilage and subchondral bone repair. The composite scaffold demonstrated modulated microstructure, mechanical properties, and conductivity by adjusting CNT concentration. In vitro evaluations showed enhanced cell proliferation, adhesion, and migration of articular cartilage cells, osteoblasts, and bone marrow mesenchymal stem cells. The composite scaffold exhibited good biocompatibility, low haemolysis rate, and high protein absorption capacity...
August 15, 2023: Pharmaceutics