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https://www.readbyqxmd.com/read/28339125/is-cuii-coordinated-to-patellamides-inside-prochloron-cells
#1
Peter Comba, Annika Eisenschmidt, Lawrence R Gahan, Dirk-Peter Herten, Geoffrey Nette, Gerhard Schenk, Martin Seefeld
Dinuclear CuII patellamide complexes (patellamides are naturally occurring cyclic pseudo-octapeptides) are known to be efficient catalysts for hydrolysis reactions of biological importance, e.g. phosphatase, carbonic anhydrase and glycosidase. However, the biological role of patellamides is still not known. Patellamides were originally extracted from the sea squirt L. patella but are now known to be ribosomally expressed by the blue-green algae Prochloron that live in symbiosis with L. patella. In a further step to unravel the metabolic significance of the patellamide complexes, the question as to whether these are also formed inside Prochloron cells is addressed...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28317767/empirical-and-bioinformatic-characterization-of-buffalo-bubalus-bubalis-colostrum-whey-peptides-their-angiotensin-i-converting-enzyme-inhibition
#2
N R Ashok, H S Aparna
Whey based peptides are well known for their nutritional and multifunctional properties. In this context, whey proteins from buffalo colostrum & milk were digested by in vitro simulation digestion and analyzed by nano-LC-MS/MS. Functional protein association networks, gene annotations and localization of identified proteins were carried out. An ACE inhibitory peptide sorted from the library was custom synthesized and an in vitro ACE assay was performed. The study led to the identification of 74 small peptides which were clustered into 5 gene functional groups and majority of them were secretory proteins...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28257938/davunetide-improves-spatial-learning-and-memory-in-alzheimer-s-disease-associated-rats
#3
Jun Zhang, Shu-Yu Wei, Li Yuan, Lin-Lin Kong, Sheng-Xiao Zhang, Zhao-Jun Wang, Mei-Na Wu, Jin-Shun Qi
Memory loss and cognition decline are the main clinical manifestations of Alzheimer's disease (AD). Amyloid β protein (Aβ) aggregated in the brain is one of the key pathological characteristics of AD and responsible for the deficits in learning and memory. It is reported that davunetide, an octapeptide derived from activity-dependent neuroprotective protein (ADNP), inhibited Aβ aggregation and Aβ-induced neurotoxicity. To further characterize the neuroprotective roles of davunetide and its possible mechanism, the present study investigated the effects of davunetide on Aβ1-42-induced impairments in spatial memory, synaptic plasticity and hippocampal AKT level...
February 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28225562/the-adipokinetic-hormone-of-mantodea-in-comparison-to-other-dictyoptera
#4
COMPARATIVE STUDY
Gerd Gäde, Heather G Marco
Six species of the order Mantodea (praying mantises) are investigated for the presence and sequence of putative adipokinetic hormones (AKHs). The selected species span a wide evolutionary range of various families and subfamilies of the clade Mantodea. The corpora cardiaca of the different species are dissected, methanolic extracts prepared, peptides separated by liquid chromatography, and AKHs detected and sequenced by ion trap mass spectrometry. All six species investigated contain an octapeptide with the primary structure pGlu-Val-Asn-Phe-Thr-Pro-Asn-Trp amide, which is code-named Emppe-AKH and had been found earlier in three other species of Mantodea...
March 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28192658/iiron-release-from-the-siderophore-pyoverdine-in-pseudomonas-aeruginosa-involves-three-new-actors-fpvc-fpvg-and-fpvh
#5
Géraldine Ganne, Karl Brillet, Beata Basta, Beatrice Roche, Françoise Hoegy, Véronique Gasser, Isabelle J Schalk
Siderophores are iron chelators produced by bacteria to access iron, an essential nutriment. Pyoverdine (PVDI), the major siderophore produced by Pseudomonas aeruginosa PAO1, consists of a fluorescent chromophore linked to an octapeptide. The ferric-form of PVDI is transported from the extracellular environment into the periplasm by the outer membrane transporter, FpvA. Iron is then released from the siderophore in the periplasm by a mechanism that does not involve chemical modification of the chelator, but an iron reduction step...
February 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28192121/convulxin-a-c-type-lectin-like-protein-inhibits-hcasmcs-functions-via-wad-motif-integrin-%C3%AE-v-interaction-and-nf-%C3%AE%C2%BAb-independent-gene-suppression-of-gro-and-il-8
#6
Chun-Ho Shih, Tin-Bin Chiang, Wen-Jeng Wang
Convulxin (CVX), a C-type lectin-like protein (CLPs), is a potent platelet aggregation inducer. To evaluate its potential applications in angiogenic diseases, the multimeric CVX were further explored on its mode of actions toward human coronary artery smooth muscle cells (HCASMCs). The N-terminus of β-chain of CVX (CVX-β) contains a putative disintegrin-like domain with a conserved motif upon the sequence comparison with other CLPs. Importantly, native CVX had no cytotoxic activity as examined by electrophoretic pattern...
March 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28164758/angiotensin-peptides-as-at2-receptor-agonists
#7
Mathias Hallberg, Jonas Sävmarker, Anders Hallberg
In 2004, the first nonpeptide selective angiotensin II type 2 receptor (AT2R) agonist was reported. This nonpeptide (C21), which, exerts anti-inflammatory and antifibrotic actions in vivo, has been extensively explored and is currently in clinical trials. Subsequently, a large number of related drug-like AT2R agonists have been disclosed. Reviews that summarize known structure-activity relationships (SAR) of nonpeptide AT2R agonists have recently appeared in the literature; however, very few reviews discuss the role of angiotensin peptides as AT2R agonists...
February 3, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28093944/healing-efficacy-of-fracture-targeted-gsk3%C3%AE-inhibitor-loaded-micelles-for-improved-fracture-repair
#8
Stewart A Low, Chris V Galliford, Yava L Jones-Hall, Jyoti Roy, Jiyuan Yang, Philip S Low, Jindřich Kopeček
AIM: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3'-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. MATERIALS & METHODS: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing. RESULTS: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls...
January 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28055219/integrating-molecular-networking-and-biological-assays-to-target-the-isolation-of-a-cytotoxic-cyclic-octapeptide-samoamide-a-from-an-american-samoan-marine-cyanobacterium
#9
C Benjamin Naman, Ramandeep Rattan, Svetlana E Nikoulina, John Lee, Bailey W Miller, Nathan A Moss, Lorene Armstrong, Paul D Boudreau, Hosana M Debonsi, Frederick A Valeriote, Pieter C Dorrestein, William H Gerwick
Integrating LC-MS/MS molecular networking and bioassay-guided fractionation enabled the targeted isolation of a new and bioactive cyclic octapeptide, samoamide A (1), from a sample of cf. Symploca sp. collected in American Samoa. The structure of 1 was established by detailed 1D and 2D NMR experiments, HRESIMS data, and chemical degradation/chromatographic (e.g., Marfey's analysis) studies. Pure compound 1 was shown to have in vitro cytotoxic activity against several human cancer cell lines in both traditional cell culture and zone inhibition bioassays...
January 5, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/27943639/genetic-prion-disease-experience-of-a-rapidly-progressive-dementia-center-in-the-united-states-and-a-review-of-the-literature
#10
REVIEW
Leonel T Takada, Mee-Ohk Kim, Ross W Cleveland, Katherine Wong, Sven A Forner, Ignacio Illán Gala, Jamie C Fong, Michael D Geschwind
Although prion diseases are generally thought to present as rapidly progressive dementias with survival of only a few months, the phenotypic spectrum for genetic prion diseases (gPrDs) is much broader. The majority have a rapid decline with short survival, but many patients with gPrDs present as slowly progressive ataxic or parkinsonian disorders with progression over a few to several years. A few very rare mutations even present as neuropsychiatric disorders, sometimes with systemic symptoms such as gastrointestinal disorders and neuropathy, progressing over years to decades...
January 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27929804/familial-creutzfeldt-jakob-disease-case-report-and-role-of-genetic-counseling-in-post-mortem-testing
#11
Kristin Clift, Kimberly Guthrie, Eric W Klee, Nicole Boczek, Margot Cousin, Patrick Blackburn, Paldeep Atwal
Here we present a case of an asymptomatic 53-year-old woman who sought genetic testing for Familial Creutzfeldt-Jakob Disease (fCJD) after learning that her mother had fCJD. The patient's mother had a sudden onset of memory problems and rapidly deteriorating mental faculties in her late 70s, which led to difficulties ambulating, progressive non-fluent aphasia, dysphagia and death within ∼1 y of symptom onset. The cause of death was reported as "rapid onset dementia." The patient's family, unhappy with the vague diagnosis, researched prion disorders online and aggressively pursued causation and submitted frozen brain tissue from the mother to the National Prion Disease Surveillance Center, where testing revealed a previously described 5-octapeptide repeat insertion (5-OPRI) in the prion protein gene (PRNP) that is known to cause fCJD...
November 2016: Prion
https://www.readbyqxmd.com/read/27926796/novel-umami-ingredients-umami-peptides-and-their-taste
#12
REVIEW
Yin Zhang, Chandrasekar Venkitasamy, Zhongli Pan, Wenlong Liu, Liming Zhao
Umami substances are very important for food seasoning and healthy eating. In addition to monosodium glutamate and some nucleotides, recent investigations have revealed that several peptides also exhibit umami taste. In recent years, 52 peptides have been reported to show umami taste, including 24 dipeptides, 16 tripeptides, 5 octapeptides, 2 pentapeptides, 2 hexapeptides, 1 tetrapeptide, 1 heptapeptide, and 1 undecapeptide. Twenty of these peptides have been examined for the present of umami taste. In this review, we have listed these umami peptides based on their category, source, taste, and threshold concentration...
January 2017: Journal of Food Science
https://www.readbyqxmd.com/read/27909427/biocombinatorial-synthesis-of-novel-lipopeptides-by-com-domain-mediated-reprogramming-of-the-plipastatin-nrps-complex
#13
Hongxia Liu, Ling Gao, Jinzhi Han, Zhi Ma, Zhaoxin Lu, Chen Dai, Chong Zhang, Xiaomei Bie
Both donors and acceptors of communication-mediating (COM) domains are essential for coordinating intermolecular communication within nonribosomal peptides synthetases (NRPSs) complexes. Different sets of COM domains provide selectivity, allowing NRPSs to utilize different natural biosynthetic templates. In this study, novel lipopeptides were synthesized by reprogramming the plipastatin biosynthetic machinery. A Thr-to-Asp point mutation was sufficient to shift the selectivity of the donor COM domain of ppsB toward that of ppsD...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27882474/effects-of-cck-8-and-cystathionine-%C3%AE-lyase-hydrogen-sulfide-system-on-acute-lung-injury-in-rats
#14
Fengjun Tian, Yiling Ling, Yuqin Chen, Zhiyong Wang
Acute lung injury (ALI) is mainly characterized by diffusive injuries to lung epithelium and increased permeability of alveolar-capillary membranes caused by various factors, which leads to pulmonary edema and pulmonary closure. Lipopolysaccharide (LPS), which is the main component of the cell wall of gram-negative bacteria, is one of the most important factors causing pulmonary infection and ALI. More and more reports have indicated that hydrogen sulfide (H2S) is closely correlated with ALI and has anti-inflammation function, while the specific mechanism needs further investigation...
November 24, 2016: Inflammation
https://www.readbyqxmd.com/read/27875906/the-therapeutic-effects-of-cholecystokinin-octapeptide-on-rat-liver-and-kidney-microcirculation-disorder-in-endotoxic-shock
#15
Dong Zhang, Hui Li, Jing Geng, Yingmin Li, Shujin Li, Chunling Ma, Bin Cong, Xiaojing Zhang
OBJECTIVES: Our previous studies demonstrated that pretreatment with cholecystokinin octapeptide (CCK-8) could alleviate endothelial cell injury and reverse abnormal vascular reactivity as well as reduce LPS-induced inflammation cascades, which suggested that CCK-8 plays a potential role in anti-endotoxic shock. The present study aimed to determine the therapeutic effects of CCK-8 on rat liver and kidney microcirculatory perfusion disorder under endotoxic shock (ES) conditions. MATERIALS AND METHODS: Sprague-Dawley rats were induced to lethal endotoxic shock by an injection of LPS...
February 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27865351/quercetin-relaxes-guinea-pig-gallbladder-strips
#16
Loren Kline, Edward Karpinski
Quercetin, a phytoestrogen and flavonoid, relaxes intestinal and vascular smooth muscle. The purpose of this study was to determine if quercetin had an effect on gallbladder smooth muscle. An in vitro technique was used to determine the effects of quercetin on gallbladder strips and which system(s) mediated the relaxation. Paired t tests were used; differences between means of P < .05 were considered significant. Adding quercetin before cholecystokinin or KCl produced a significant (P < .001) decrease in the amount of tension (0...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27855337/osteotropic-peptide-mediated-bone-targeting-for-photothermal-treatment-of-bone-tumors
#17
Yitong Wang, Jian Yang, Hongmei Liu, Xinyu Wang, Zhengjie Zhou, Quan Huang, Dianwen Song, Xiaopan Cai, Lin Li, Kaili Lin, Jianru Xiao, Peifeng Liu, Qiang Zhang, Yiyun Cheng
The treatment of bone tumors is a challenging problem due to the inefficient delivery of therapeutics to bone and the bone microenvironment-associated tumor resistance to chemo- and radiotherapy. Here, we developed a bone-targeted nanoparticle, aspartate octapeptide-modified dendritic platinum-copper alloy nanoparticle (Asp-DPCN), for photothermal therapy (PTT) of bone tumors. Asp-DPCN showed much higher affinity toward hydroxyapatite and bone fragments than the non-targeted DPCN in vitro. Furthermore, Asp-DPCN accumulated more efficiently around bone tumors in vivo, and resulted in a higher temperature in bone tumors during PTT...
November 9, 2016: Biomaterials
https://www.readbyqxmd.com/read/27832662/effects-of-exogenous-interleukin-9-on-the-growth-proliferation-and-activity-of-interstitial-cells-of-cajal-cultured-in-vitro
#18
Lei Huang, Baofeng Du, Yaoyao Gong, Hairong Xu, Jia Lu, Xinmin Si
OBJECTIVES: To evaluate the role of exogenous interleukin-9 (IL-9) in the growth, proliferation and activity of interstitial cells of Cajal (ICCs) cultured in vitro, and to assess its role in maintaining the functions of ICCs. METHODS: ICCs of murine gastric antrum were isolated and cultured in vitro. ICCs were identified with c-Kit and ANO1 immunofluorescent antibodies. Both fluorescence microscope and confocal microscopy were used to observe the effects of IL-9 on the growth, proliferation and activity of ICCs in cultured in vitro...
2016: Digestion
https://www.readbyqxmd.com/read/27715017/radiosynthesis-and-preclinical-evaluation-of-18-f-fluoroglycosylated-octreotate-for-somatostatin-receptor-imaging
#19
Simone Maschauer, Marcus Heilmann, Carmen Wängler, Ralf Schirrmacher, Olaf Prante
Short synthetic octapeptide analogs derived from the native somatostatin peptides SST-14 and SST-28, namely, octreotate (TATE) or octreotide (TOC), bind with high affinity to somatostatin receptors (sstr), mainly to subtypes 2 and 5, which are expressed in high density on neuroendocrine tumors (NET). Therefore, radiolabeled TATE or TOC derivatives represent highly valuable imaging probes for NET diagnosis by positron emission tomography (PET). The aim of our study was the development of an (18)F-labeled octreotate analog as an alternative radiotracer for the clinically established (68)Ga-DOTATOC and (68)Ga-DOTATATE...
November 16, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27713939/novel-tubulin-targeted-cell-penetrating-antimitotic-octapeptide
#20
Debmalya Bhunia, Saswat Mohapatra, Prashant Kurkute, Subhajit Ghosh, Batakrishna Jana, Prasenjit Mondal, Abhijit Saha, Gaurav Das, Surajit Ghosh
An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells.
October 18, 2016: Chemical Communications: Chem Comm
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