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Kaempferol AND FoxO

Xinrui Xing, Si Chen, Ling Li, Yan Cao, Langdong Chen, Xiaobo Wang, Zhenyu Zhu
Purpose: This study aimed to identify the active components of Fuzheng Huayu (FZHY) formula and the mechanism by which they inhibit the viability of hepatic stellate cells (HSCs) by a combination of network pharmacology and transcriptomics. Methods: The active components of FZHY formula were screened out by text mining. Similarity match and molecular docking were used to predict the target proteins of these compounds. We then searched the STRING database to analyze the key enriched processes, pathways and related diseases of these target proteins...
2018: Frontiers in Pharmacology
Gregor Grünz, Kerstin Haas, Sebastian Soukup, Martin Klingenspor, Sabine E Kulling, Hannelore Daniel, Britta Spanier
Various studies have demonstrated longevity effects of flavonoids, a major sub-group of plant polyphenolic compounds, in Caenorhabditis elegans. To better understand their structure-activity relationship in vivo we have used a comparative approach by exposing C. elegans to the structurally related flavonoids myricetin, quercetin, kaempferol and naringenin, and assessed their impact on lifespan and on putative modes of action. The bioavailability of the tested flavonoids was demonstrated by high-performance liquid chromatography with diode-array detection (HPLC/DAD) and a 2-aminoethyl diphenyl borate-based in vivo approach...
January 2012: Mechanisms of Ageing and Development
Andreas Kampkötter, Christiane Gombitang Nkwonkam, Ruben Felix Zurawski, Claudia Timpel, Yvonni Chovolou, Wim Wätjen, Regine Kahl
Flavonoids present in many herbal edibles possess a remarkable spectrum of biochemical and pharmacological actions and they are assumed to exert beneficial effects to human health. Although the precise biological mechanisms of their action has not been elucidated yet many of the protective properties of flavonoids are attributed to their antioxidative activity since oxidative stress is regarded as a main factor in the pathophysiology of various diseases and ageing. Oxidative stress results from excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence and thus antioxidants are able to counteract such situations...
December 2007: Archives of Toxicology
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