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Kaempferol AND Pax4

Hua Li, Hyeon-Seon Ji, Ji-Hyun Kang, Dong-Ha Shin, Ho-Yong Park, Myung-Sook Choi, Chul-Ho Lee, In-Kyung Lee, Bong-Sik Yun, Tae-Sook Jeong
This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression...
August 19, 2015: Journal of Agricultural and Food Chemistry
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