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https://www.readbyqxmd.com/read/29649953/prevalence-and-variables-associated-with-an-abnormal-ankle-brachial-index-among-patients-with-human-immunodeficiency-virus-acquired-immunodeficiency-syndrome
#1
Carlos A Hinojosa, Ana E Nunez-Salgado, Javier E Anaya-Ayala, Hugo Laparra-Escareno, Laura J Ortiz-Lopez, Jaime O Herrera-Caceres, Brenda E Crabtree-Ramirez, Juan G Sierra-Madero
Objectives The longer survival of patients with human immunodeficiency virus/acquired immunodeficiency syndrome and the introduction of the highly active antiretroviral therapy have increased the number of chronic conditions; among these, cardiovascular diseases. The aim of this study is to determine patient, disease, and factors associated with peripheral arterial disease in a population of patients with human immunodeficiency virus/acquired immunodeficiency syndrome. Methods A prospective nested case-control study of a cohort of patients with human immunodeficiency virus/acquired immunodeficiency syndrome was conducted in a tertiary medical center in Mexico City...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29625575/targeted-genome-engineering-in-human-induced-pluripotent-stem-cells-from-patients-with-hemophilia-b-using-the-crispr-cas9-system
#2
Cuicui Lyu, Jun Shen, Rui Wang, Haihui Gu, Jianping Zhang, Feng Xue, Xiaofan Liu, Wei Liu, Rongfeng Fu, Liyan Zhang, Huiyuan Li, Xiaobing Zhang, Tao Cheng, Renchi Yang, Lei Zhang
BACKGROUND: Replacement therapy for hemophilia remains a lifelong treatment. Only gene therapy can cure hemophilia at a fundamental level. The clustered regularly interspaced short palindromic repeats-CRISPR associated nuclease 9 (CRISPR-Cas9) system is a versatile and convenient genome editing tool which can be applied to gene therapy for hemophilia. METHODS: A patient's induced pluripotent stem cells (iPSCs) were generated from their peripheral blood mononuclear cells (PBMNCs) using episomal vectors...
April 6, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29581938/did-diabetes-mellitus-affect-treatment-outcome-in-drug-resistant-tuberculosis-patients-in-pakistan-from-2010-to-2014
#3
A Latif, A Ghafoor, A Wali, R Fatima, Mahboob Ul-Haq, A Yaqoob, Z Abdullah, H Najmi, N M Khan
Settings: All hospitals managing drug-resistant tuberculosis (DR-TB) according to national guidelines in Pakistan. Objectives: To assess the effect of diabetes mellitus (DM) and factors associated with unfavourable outcomes in DR-TB. Methods: A cross-sectional study based on a retrospective record review of patients enrolled on DR-TB treatment from 2010 to 2014 in Pakistan. DR-TB data reported to Pakistan's National TB Control Programme on a monthly basis were used for the study. Result: Among 5811 patients enrolled on second-line drugs, 8...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29573032/visualizing-the-effects-of-metformin-on-tumor-growth-vascularity-and-metabolism-in-head-and-neck-cancer
#4
Aparajita Verma, Laurie J Rich, Vincent Chong Vui King, Mukund Seshadri
BACKGROUND: The anti-diabetic drug Metformin (Met) is believed to inhibit tumor proliferation by altering the metabolism of cancer cells. In this study, we examined the effects of on tumor oxygenation, metabolism and growth in head and neck squamous cell carcinoma (HNSCC) using non-invasive multimodal imaging MATERIALS AND METHODS: Severe combined immunodeficient (SCID) mice bearing orthotopic FaDu HNSCC xenografts were treated with Met (200 mg/kg, i.p.) once daily for 5 days. Tumor oxygen saturation (%sO2 ) and hemoglobin concentration (HbT) were measured using photoacoustic imaging (PAI)...
March 23, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29563561/comorbidities-and-treatment-outcomes-in-multidrug-resistant-tuberculosis-a-systematic-review-and-meta-analysis
#5
Joel Philip Samuels, Aashna Sood, Jonathon R Campbell, Faiz Ahmad Khan, James Cameron Johnston
Little is known about the impact of comorbidities on multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to examine the effect of human immunodeficiency virus (HIV), diabetes, chronic kidney disease (CKD), alcohol misuse, and smoking on MDR/XDRTB treatment outcomes. We searched MEDLINE, EMBASE, Cochrane Central Registrar and Cochrane Database of Systematic Reviews as per PRISMA guidelines. Eligible studies were identified and treatment outcome data were extracted...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29558525/atrial-arrhythmia-prevalence-and-characteristics-for-human-immunodeficiency-virus-infected-persons-and-matched-uninfected-controls
#6
Jes M Sanders, Alexandra B Steverson, Anna E Pawlowski, Daniel Schneider, Chad J Achenbach, Donald M Lloyd-Jones, Matthew J Feinstein
BACKGROUND: Human Immunodeficiency Virus-Infected (HIV+) persons have elevated risks for various manifestations of cardiovascular disease (CVD). No studies to our knowledge have compared atrial fibrillation (AF) and atrial flutter (AFL) prevalence and associated characteristics for HIV+ persons and matched uninfected controls. METHODS AND FINDINGS: Persons with diagnoses of HIV receiving care at a large urban academic medical center were frequency-matched 1:2 on age, sex, race, zip code, and clinic location with uninfected persons...
2018: PloS One
https://www.readbyqxmd.com/read/29553548/intrasplenic-transplantation-of-hepatocytes-after-partial-hepatectomy-in-nod-scid-mice
#7
Barun Das, Jashdeep Bhattacharjee, Preeti, Alaknanda Mishra, Kshama Jain, Srikanth Iyer, Ashwani Kesarwani, Parul Sahu, Prakriti Sinha, Perumal Nagarajan, Pramod Upadhyay
Partial hepatectomy is a versatile and reproducible method to study liver regeneration and the effect of cell based therapeutics in various pathological conditions. Partial hepatectomy also facilitates the increased engraftment and proliferation of transplanted cells by accelerating neovascularization and cell migration towards the liver. Here, we describe a simple protocol for performing 30% hepatectomy and transplantation of cells in the spleen of a non-obese diabetic/severe combined immunodeficient NOD.SCID (NOD...
February 10, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29552124/characterization-of-human-gastric-adenocarcinoma-cell-lines-established-from-peritoneal-ascites
#8
Bożenna Mytar, Małgorzata Stec, Rafał Szatanek, Kazimierz Węglarczyk, Katarzyna Szewczyk, Antoni Szczepanik, Grażyna Drabik, Jarek Baran, Maciej Siedlar, Monika Baj-Krzyworzeka
The three cell lines, designated as gastric cancer (GC)1401, GC1415 and GC1436 were derived from peritoneal effusions from patients with gastric adenocarcinoma. Cell lines were established in tissue culture and in immunodeficient, non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice. All cell lines were cultured in Dulbecco's modified Eagle's medium supplemented with 5% fetal bovine serum. These cell lines were grown as an adherent monolayer with doubling time ranging between 25 h (GC1436 cell line) and 30-34 h (GC1401 and GC1415, respectively)...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29548898/long-term-outcome-of-eight-patients-with-type-1-leukocyte-adhesion-deficiency-lad-1-not-only-infections-but-high-risk-of-autoimmune-complications
#9
Domenico Umberto De Rose, Silvia Giliani, Lucia Dora Notarangelo, Vassilios Lougaris, Arnalda Lanfranchi, Daniele Moratto, Baldassarre Martire, Fernando Specchia, Alberto Tommasini, Alessandro Plebani, Raffaele Badolato
Leukocyte Adhesion Deficiency type 1 (LAD-1) is a rare primary immunodeficiency due to mutations in the gene encoding for the common β-chain of the β2 integrin family (CD18). Herein, we describe clinical manifestations and long-term complications of eight LAD-1 patients. Four LAD-1 patients were treated with hematopoietic stem cell transplantation (HSCT), while the remaining four, including two with moderate LAD-1 deficiency, received continuous antibiotic prophylaxis. Untreated patients presented numerous infections and autoimmune manifestations...
March 13, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29531797/aspergillus-spinal-epidural-abscess-case-presentation-and-review-of-the-literature
#10
Faris Shweikeh, Stephanie Zyck, Fadi Sweiss, Ajleeta Sangtani, Mohammed Shweikeh, Husam Issa, Michael P Steinmetz, Georges Z Markarian
Study design: In this review, we present a case of Aspergillus spinal epidural abscess (ASEA) and review the literature. Objectives: To provide further insight on a rare condition. Setting: A description of a patient with ASEA in a 58-year-old woman that was successfully treated with conservative management is presented. Methods: Following case presentation, a literature search (MedLine and PubMed) and assessment of epidemiology, presentation, diagnosis, treatments, and outcomes is performed...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29519870/leukemia-reconstitution-in-vivo-is-driven-by-cells-in-early-cell-cycle-and-low-metabolic-state
#11
Luca Trentin, Manon Queudeville, Sarah Mirjam Eckhoff, Md Nabiul Hasan, Vera Münch, Elena Boldrin, Felix Seyfried, Stefanie Enzenmüller, Klaus-Michael Debatin, Lüder Hinrich Meyer
In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations as defined by surface markers have shown equal abilities to reconstitute leukemia upon transplantation onto immunodeficient mice. Using a non-obese diabetes/severe combined immunodeficiency human acute lymphoblastic leukemia mouse model and cell cycle analysis annotating cells to distinct cycle phases, we have functionally characterized leukemia-initiating cells and found that cells in all cell cycle stages are able to reconstitute leukemia in vivo, with early cycling cells (G1blow population) exhibiting the highest leukemia-initiating potential...
March 8, 2018: Haematologica
https://www.readbyqxmd.com/read/29516879/patients-at-high-risk-of-tuberculosis-recurrence
#12
REVIEW
Mehdi Mirsaeidi, Ruxana T Sadikot
Recurrent tuberculosis (TB) continues to be a significant problem and is an important indicator of the effectiveness of TB control. Recurrence can occur by relapse or exogenous reinfection. Recurrence of TB is still a major problem in high-burden countries, where there is lack of resources and no special attention is being given to this issue. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 47%. This variability is related to differences in regional epidemiology of recurrence and differences in the definitions used by the TB control programs...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29503651/antigen-loading-e-g-glutamic-acid-decarboxylase-65-of-tolerogenic-dcs-toldcs-reduces-their-capacity-to-prevent-diabetes-in-the-non-obese-diabetes-nod-severe-combined-immunodeficiency-model-of-adoptive-cotransfer-of-diabetes-as-well-as-in-nod-mice
#13
David P Funda, Jaroslav Goliáš, Tomáš Hudcovic, Hana Kozáková, Radek Špíšek, Lenka Palová-Jelínková
Tolerogenic DCs (tolDCs) are being researched as a promising intervention strategy also in autoimmune diseases including type 1 diabetes (T1D). T1D is a T-cell-mediated, organ-specific disease with several well-defined and rather specific autoantigens, i.e., proinsulin, insulin, glutamic acid decarboxylase 65 (GAD65), that have been used in animal as well as human intervention trials in attempts to achieve a more efficient, specific immunotherapy. In this study, we have tested tolerogenic DCs for their effectiveness to prevent adoptive transfer of diabetes by diabetogenic splenocytes into non-obese diabetes (NOD)-severe combined immunodeficiency (NOD-SCID) recipients...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29500792/safety-and-efficacy-of-epigenetically-converted-human-fibroblasts-into-insulin-secreting-cells-a-preclinical-study
#14
Tiziana A L Brevini, Georgia Pennarossa, Elena F M Manzoni, Fulvio Gandolfi
Type 1 Diabetes Mellitus (T1DM) is a chronic disease that leads to loss of insulin secreting β-cells, causing high levels of blood glucose. Exogenous insulin administration is not sufficient to mimic the normal function of β-cells and, consequently, diabetes mellitus often progresses and can lead to major chronic complications and morbidity. The physiological control of glucose levels can only be restored by replacing the β-cell mass.We recently developed a new strategy that allows for epigenetic conversion of dermal fibroblasts into insulin-secreting cells (EpiCC), using a brief exposure to the demethylating agent 5-aza-cytidine (5-aza-CR), followed by a pancreatic induction protocol...
March 3, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29498913/acute-pancreatitis-in-patients-with-severe-hypertriglyceridemia-in-a-multiethnic-minority-population
#15
Ambika Amblee, Divyanshu Mohananey, Micheal Morkos, Sanjib Basu, Ayokunle Abegunde, Malini Ganesh, Neil Bhalerao, Amrutha Mary George, Milli Jain, Leon Fogelfeld
OBJECTIVE: To investigate the prevalence and predictors of hypertriglycerdemic acute pancreatitis (HTG-AP) in a multiethnic minority population. METHODS: A retrospective cross-sectional study from 2003 to 2013 of 1157 adults with serum triglyceride (TG) level ≥ 1000 mg/dL comparing baseline characteristics and risk factors between those with and without HTG-AP. RESULTS: Mean study population age was 49.2±11.5 years; 75.6% males; 31.6% African Americans, 38...
March 2, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29489704/factors-contributing-to-phlebitis-among-adult-patients-admitted-in-the-medical-surgical-units-of-a-central-hospital-in-harare-zimbabwe
#16
Munashe Livion Nyika, Doreen Mukona, Mathilda Zvinavashe
This descriptive survey identified factors contributing to phlebitis among 46 adult inpatients using a systematic random sample. The visual infusion phlebitis score was used for assessment. All participants had phlebitis, with stage 4 being most frequent. Factors identified were gender (males-91.7%); immunosuppression (human immunodeficiency virus-63.0%; diabetes-100%; immunosuppressive drugs-100%; absolute leucocyte count <1000 μL-100%); number of catheters inserted (>1-90.9%); site of catheterization (dorsum of wrist-100%); catheter dwell time (2-4 days-100%); catheter gauge (18-gauge-75%); catheter securement (unsecured/contaminated dressing-90%); regularity of catheter flushing (catheter never flushed-72...
March 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29483948/prevalence-and-predictors-of-metabolic-syndrome-among-people-living-with-human-immunodeficiency-virus-plwhiv
#17
Dula Dessalegn Bosho, Lemessa Dube, Teshale Ayele Mega, Dawit Abera Adare, Mikyas Gashaw Tesfaye, Tesfahun Chanie Eshetie
Background: Use of combination antiretroviral therapy (cART) has led to significant reductions in morbidity and mortality. However, there is a growing concern about metabolic syndromes (MS), among patients receiving cART. Despite this fact, there is limited evidence for the prevalence of the MS among HIV-infected persons receiving cART in developing countries, particularly Ethiopia. Objective: To determine the prevalence and predictors of MS among people living with HIV/AIDS in Jimma health centre, Jimma Zone south west Ethiopia...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29473266/anti-human-sirp%C3%AE-antibody-is-a-new-tool-for-cancer-immunotherapy
#18
Yoji Murata, Daisuke Tanaka, Daisuke Hazama, Tadahiko Yanagita, Yasuyuki Saito, Takenori Kotani, Per-Arne Oldenborg, Takashi Matozaki
Interaction of signal regulatory protein α (SIRPα) expressed on the surface of macrophages with its ligand CD47 expressed on target cells negatively regulates phagocytosis of the latter cells by the former. We recently showed that blocking Abs to mouse SIRPα enhanced both the Ab-dependent cellular phagocytosis (ADCP) activity of mouse macrophages for Burkitt's lymphoma Raji cells opsonized with an Ab to CD20 (rituximab) in vitro as well as the inhibitory effect of rituximab on the growth of tumors formed by Raji cells in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice...
February 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29458268/plhiv-are-more-likely-to-have-mental-distress-evidence-from-a-comparison-of-a-cross-section-of-hiv-and-diabetes-patients-at-tertiary-hospitals-in-nigeria
#19
Olumide Abiodun, Ismail Lawal, Christopher Omokanye
HIV is now regarded as a chronic disease because of the availability of treatment. However, it is not well known if there are differences (clinically and in magnitude) between the mental health status of PLHIV and people living with other chronic diseases. The aim of this study was to compare the mental health status of patients attending antiretroviral clinics to patients attending diabetes clinics at tertiary hospitals in Ogun State, Nigeria. A comparative hospital-based cross-sectional study of mental distress among 639 HIV-positive and 639 diabetic patients was carried out...
February 19, 2018: AIDS Care
https://www.readbyqxmd.com/read/29456222/prevalence-and-risk-factors-of-chronic-kidney-disease-in-cote-d-ivoire-an-analytic-study-conducted-in-the-department-of-internal-medicine
#20
Hubert Kouame Yao, Serge Didier Konan, Sindou Sanogo, Sery Patrick Diopoh, Amadou Demba Diallo
Chronic kidney disease (CKD) has become a public health problem because of its increasing prevalence. The objective of this study was to describe the current profile of CKD in our working conditions. This is a descriptive retrospective study of patients admitted for CKD during the period from January 2010 to December 2014 in the Internal Medicine Department of the university hospital of Treichville in Abidjan. CKD was defined by a glomerular filtration rate below 60 mL/min lasting for at least three months...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
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