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https://www.readbyqxmd.com/read/28343046/perioperative-hemoglobin-a1c-as-a-predictor-of-deep-infection-following-single-level-lumbar-decompression-in-patients-with-diabetes
#1
Jourdan M Cancienne, Brian C Werner, Dennis Q Chen, Hamid Hassanzadeh, Adam L Shimer
BACKGROUND CONTEXT: Although multiple studies have cited diabetes mellitus as a risk factor decreased functional outcomes, increased infectious complications, and overall increased reoperation rate following degenerative lumbar spinal surgery, few have investigated how perioperative glycemic control influences such complications. PURPOSE: The primary goal of the present study was to use a national database to evaluate the association of perioperative glycemic control as demonstrated by Hemoglobin A1c levels in patients with diabetes undergoing primary, single level decompression without concomitant fusion with the incidence of deep postoperative infection following requiring operative irrigation and debridement...
March 22, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28340138/a-life-without-worms
#2
Richard E Sanya, Gyaviira Nkurunungi, Irene Andia Biraro, Harriet Mpairwe, Alison M Elliott
Worms have co-evolved with humans over millions of years. To survive, they manipulate host systems by modulating immune responses so that they cause (in the majority of hosts) relatively subtle harm. Anthelminthic treatment has been promoted as a measure for averting worm specific pathology and to mitigate subtle morbidities which may include effects on anaemia, growth, cognitive function and economic activity. With our changing environment marked by rapid population growth, urbanisation, better hygiene practices and anthelminthic treatment, there has been a decline in worm infections and other infectious diseases and a rise in non-communicable diseases such as allergy, diabetes and cardiovascular disease...
March 18, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28337065/acute-bacterial-endophthalmitis-following-intravitreal-dexamethasone-implant-a-case-report-and-review-of-literature
#3
Neha Goel
Endophthalmitis following intravitreal dexamethasone (DEX) implant has been rarely reported. This report describes the case of a 70-year-old male who underwent intravitreal DEX implant injection under aseptic conditions, for diabetic macular edema. He developed a clinical picture suggestive of endophthalmitis within 2 weeks of the injection, and vitreous culture grew coagulase negative Staphylococcus. He was treated with intravitreal antibiotics followed by pars plana vitrectomy and removal of the implant...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336821/hyperbaric-oxygen-therapy-reduces-renal-lactate-production
#4
Thomas S Nørlinger, Per Mose Nielsen, Haiyun Qi, Emmeli Mikkelsen, Kasper Hansen, Nikolaj H Schmidt, Michael Pedersen, Peter Agger, Fredrik Palm, Christoffer Laustsen
Intrarenal hypoxia is an acknowledged factor contributing to the development of diabetic nephropathy. Hyperbaric oxygen (HBO) therapy is a well-known adjuvant treatment for several medical conditions, such as decompression sickness, infections, and wound healing. The underlying metabolic response of HBO is largely unknown. In this study, we investigated the effect of HBO on the intrarenal metabolic alteration in diabetes. Hyperpolarized [1-(13)C]pyruvate MRI was performed to assess intrarenal energy metabolism in normoglycemic controls and short-term (2 weeks) streptozotocin-induced diabetic rats with and without HBO for five consecutive days...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28336466/global-trends-and-predictions-in-hepatocellular-carcinoma-mortality
#5
Paola Bertuccio, Federica Turati, Greta Carioli, Teresa Rodriguez, Carlo La Vecchia, Matteo Malvezzi, Eva Negri
BACKGROUND: Hepatocellular carcinoma (HCC) has been one of the few cancers showing upward trends over recent decades in most countries, and is the third cause of cancer death worldwide. PATIENTS AND METHODS: We updated global trends in HCC mortality to 2014, and predicted trends in rates in the EU, USA and Japan to 2020, using data from the World Health Organization database. RESULTS: In EU men, mortality rates were stable in the last decade around 3...
March 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28336292/structural-elucidation-and-physiologic-functions-of-specialized-pro-resolving-mediators-and-their-receptors
#6
REVIEW
Nan Chiang, Charles N Serhan
The acute inflammatory response is host protective to contain foreign invaders. Many of today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious unwanted side effects such as immune suppression. Uncontrolled inflammation is now considered a pathophysiologic basis associated with, many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as well as the classic inflammatory diseases, e.g. arthritis, periodontal diseases...
March 20, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28333172/aesthetic-breast-surgery-and-concomitant-procedures-incidence-and-risk-factors-for-major-complications-in-73-608-cases
#7
Varun Gupta, Max Yeslev, Julian Winocour, Ravinder Bamba, Charles Rodriguez-Feo, James C Grotting, K Kye Higdon
Background: Major complications following aesthetic breast surgery are uncommon and thus assessment of risk factors is challenging. Objectives: To determine the incidence and risk factors of major complications following aesthetic breast surgery and concomitant procedures. Methods: A prospective cohort of patients who enrolled into the CosmetAssure (Birmingham, AL) insurance program and underwent aesthetic breast surgery between 2008 and 2013 was identified...
January 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28332921/leaving-the-skin-incision-open-may-not-be-as-beneficial-as-we-have-been-taught
#8
Jack C He, Brenda M Zosa, David Schechtman, Brian Brajcich, Jonathan C Savakus, Amanda L Wojahn, Derek Z Wang, Jeffrey A Claridge
BACKGROUND: Currently, various methods of skin closures are used in contaminated and dirty abdominal wounds without solid, evidence-based guidance. This study investigates whether closure methods affect surgical site infection (SSI) and other incisional complications. We hypothesize that open management of the skin would have the lowest complications, including SSI. PATIENTS AND METHODS: Patients age ≥18 who underwent trauma laparotomy (TL) or damage control laparotomy (DCL) from 2008-2013 and had class III/IV wounds were included...
March 23, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28332067/preoperative-chronic-sinusitis-as-significant-cause-of-postoperative-infection-and-implant-loss-after-sinus-augmentation-from-a-lateral-approach
#9
Ayako Kozuma, Masanori Sasaki, Katsuhiro Seki, Takeshi Toyoshima, Hiroyuki Nakano, Yoshihide Mori
OBJECTIVES: Among intra/postoperative complications of sinus augmentation from a lateral approach, postoperative infection and implant loss are particularly important because they have irreversible consequences. The purpose of this study was to determine the causes of postoperative infection and implant loss after a lateral approach and to determine the appropriate prophylaxis and therapy. MATERIALS AND METHODS: In total, 109 patients (121 sinuses, 252 implants) were included in this study...
March 22, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28331806/myroides-bacteremia-a-case-report-and-concise-review
#10
Rudra Beharrysingh
Myroides species are bacteria found commonly in environmental sources, such as water and soil. Despite this, they are historically uncommon pathogens, tending to affect primarily immunocompromised hosts. Based on a review of the current cases listed in the U.S. National Institutes of Health's National Library of Medicine (Table 1), there have been 48 reported cases of infection to date, one third of which have been reported in only the last seven years. This report outlines a case of bacteremia caused by Myroides species occurring in a diabetic male on chemotherapy for Merkel cell cancer...
2017: IDCases
https://www.readbyqxmd.com/read/28330739/the-impact-of-metabolic-syndrome-and-its-components-on-perioperative-outcomes-after-elective-laparotomy-a-prospective-observational-study
#11
Eleni Laou, Haralampos Milionis, Anastasios Petrou, Eleni Arnaoutoglou, Georgios Glantzounis, Eleni Bairaktari, Dimitrios Mavridis, Dimitri P Mikhailidis, Georgios Papadopoulos, Petros Tzimas
BACKGROUND: Metabolic syndrome (MetS) represents a constellation of risk factors, including central obesity, elevated fasting blood glucose, high blood pressure and atherogenic dyslipidemia. This prospective observational study aimed to assess the impact of MetS on perioperative outcomes of patients undergoing elective abdominal surgery with laparotomy. METHODS: We included 105 consecutive non-diabetic patients undergoing elective abdominal surgery with laparotomy...
March 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28330585/molecular-detection-of-leptospirosis-and-melioidosis-co-infection-a-case-report
#12
Mohammad Ridhuan Mohd Ali, Amira Wahida Mohamad Safiee, Padmaloseni Thangarajah, Mohd Hashairi Fauzi, Alwi Muhd Besari, Nabilah Ismail, Chan Yean Yean
Leptospirosis and melioidosis are important tropical infections caused by Leptospira and Burkholdheria pseudomallei, respectively. As both infections share similar clinical manifestations yet require different managements, complementary laboratory tests are crucial for the diagnosis. We describe a case of Leptospira and B. pseudomallei co-infection in a diabetic 40-year-old woman with history of visit to a freshwater camping site in northern Malaysia. To our knowledge, this is the first case of such double-infection, simultaneously demonstrated by molecular approach...
March 15, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28329664/prospective-evaluation-of-complications-in-dermatologic-surgery-associated-with-hypertension-conroy
#13
Conroy Chow, Matthew J Simpson, Niko Pascua, Harjot Maan, Jacqueline G Berlier, Siegrid Yu, Isaac Neuhaus, Roy Grekin, Sarah T Arron
BackgroundPoorly controlled hypertension is a known risk factor for surgical complications. OBJECTIVE: This study examines the incidence of complications in participants undergoing Mohsmicrographic surgery (MMS) based on preoperative blood pressure (BP) measurement and investigates the role of potential confounders in the relationship between preoperative BP and postoperative complications.MethodsThis 10-month prospective cohort study at the University of California, San Francisco (UCSF) Dermatologic Surgery Center approached all patients undergoing MMS for participation and assessed for the diagnosis of hypertension, anti-hypertensive medication use, use of tobacco or blood thinners, immunosuppression, concomitant diabetes, or previous treatment with radiation therapy at the surgical site...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329633/comorbidities-of-hospitalized-pemphigus-patients-in-the-united-states
#14
Derek Y Hsu Y Hsu
We sought to determine the comorbid health conditions and inpatient mortality associated with pemphigus in a U.S. inpatient cohort. The 2002-2012 Nationwide Inpatient Sample, which contains a representative 20% stratified sample of all inpatient hospitalizations in the US, was analyzed. Comorbidities were determined through ICD-9-CM codes. Survey weighted multivariate logistic regression models controlling for demographic factors were constructed to determine the association of pemphigus with various comorbidities...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329325/comparison-of-radial-and-bilateral-internal-thoracic-artery-grafting-in-patients-with-peripheral-vascular-disease%C3%A2
#15
Dmitry Pevni, Yanai Ben-Gal, Rephael Mohr, Nadav Teich, Zvi Raviv, Amir Kramer, Yosef Paz, Benjamin Medalion, Nahum Nesher
OBJECTIVES: The composite T-graft with radial artery (RA) attached end-to-side to the left internal thoracic artery (ITA) provides arterial myocardial revascularization without the increased risk of deep sternal wound infection associated with harvesting 2 ITAs. However, many surgeons are reluctant to use RA in patients with peripheral vascular disease (PVD) due to concerns regarding the quality of the conduit in this subset of patients. The purpose of this study is to compare early- and long-term outcomes of arterial grafting with bilateral ITAs (BITA) to that of single ITA and RA in patients with PVD...
March 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28328638/complications-after-reduction-mammaplasty-a-comparison-of-wise-pattern-inferior-pedicle-and-vertical-scar-superomedial-pedicle
#16
Adeyemi A Ogunleye, Ofelia Leroux, Norman Morrison, Aviva B Preminger
Reduction mammaplasty is a commonly-performed procedure among plastic surgeons. Although several methods exist, the Wise pattern/inferior pedicle (IP) technique is the most widely used. The vertical scar/superomedial pedicle (SP) technique has gained acceptance for its shorter scar and more durable projection results, but some hesitation remains with its use in larger volume reductions.The incidence of complications in 124 consecutively performed breast reductions (246 breasts) at a single institution using either the Wise pattern/IP technique or vertical scar/SP technique, as well as risk factors associated with them, was determined...
March 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28326851/evaluation-of-antibacterial-activity-of-the-bark-and-leaf-extracts-of-brosimum-gaudichaudii-tr%C3%A3-cul-against-multidrug-resistant-strains
#17
Joelma da Costa Borges, Michele Cezimbra Perim, Rodrigo Orlandini de Castro, Thiago Antônio de Sousa Araújo, Tadeu José da Silva Peixoto Sobrinho, Ana Carolina Oliveira da Silva, Sandra Maria Botelho Mariano, Solange Cristina Carreiro, Maria Cristina da Silva Pranchevicius
Brosimum gaudichaudii Trécul., a plant that belongs to Moraceae family, is found throughout the Brazilian Cerrado. The antimicrobial activities of ethanolic bark and leaf extracts of B. gaudichaudii were tested against multiresistant bacteria isolated from diabetic foot infections (DFIs). Antimicrobial activity of the extracts was evaluated by agar disc diffusion (DD) and broth dilution (BD) methods. By BD method, bark (53.85, 45.83%) and leaf (42.31, 50.00%) extracts contained antimicrobial activity against both gram-negative and gram-positive bacteria...
March 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28326825/role-of-biomarkers-in-predicting-diabetes-complications-with-special-reference-to-diabetic-foot-ulcers
#18
Sivakamasundari Pichu, Bhoomika M Patel, Subbu Apparsundaram, Ramesh K Goyal
Diabetic foot ulcer (DFU) is one of the major complications of diabetes and about 1% of people with diabetes have to go for lower limb amputation. With better understanding of the pathological basis of DFU, number of biomarkers like atrial natriuretic peptides, galectin-3, and cardiac troponins for diabetic cardiomyopathy, cystatin C for diabetics nephropathy and C-reactive protein for infection and procalcitonin could aid in early and noninvasive diagnosis especially when clinical signs are misleading. Predictive role of novel biomarkers in primary prevention however, requires additional studies considering sex, age and multiple complications in DFU...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326328/cooccurrences-of-putative-endogenous-retrovirus-associated-diseases
#19
REVIEW
Christine Brütting, Alexander Emmer, Malte E Kornhuber, Martin S Staege
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences. ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses. On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes mellitus (T1D), or amyotrophic lateral sclerosis (ALS). Little is known about the cooccurrence of these diseases. If all these diseases are caused by ERV, antiretroviral therapy should perhaps also show some effects in the other diseases...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28326158/diabetic-limb-salvage-procedure-with-bone-allograft-and-free-flap-transfer-a-case-report
#20
Alexandre L Godoy-Santos, Daniel T Amodio, André Pires, Ana L M Lima, Teng H Wei, Cesar de Cesar-Netto, David G Armstrong
The aim of this case report was to describe a successful diabetic limb salvage procedure in the treatment of an infected diabetic foot ulcer through a multidisciplinary team approach and complex surgical reconstruction involving a femoral head bone allograft and musculocutaneous latissimus dorsi free flap. The decision to proceed with aggressive staged efforts at diabetic limb salvage should be made only after careful consultation with the patient, his or her family, and the rest of the multidisciplinary healthcare team...
2017: Diabetic Foot & Ankle
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