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Pax4 AND supplements

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https://www.readbyqxmd.com/read/26211813/soy-leaf-extract-containing-kaempferol-glycosides-and-pheophorbides-improves-glucose-homeostasis-by-enhancing-pancreatic-%C3%AE-cell-function-and-suppressing-hepatic-lipid-accumulation-in-db-db-mice
#1
Hua Li, Hyeon-Seon Ji, Ji-Hyun Kang, Dong-Ha Shin, Ho-Yong Park, Myung-Sook Choi, Chul-Ho Lee, In-Kyung Lee, Bong-Sik Yun, Tae-Sook Jeong
This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression...
August 19, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/24567802/identification-and-differentiation-of-pdx1-%C3%AE-cell-progenitors-within-the-human-pancreatic-epithelium
#2
Karen L Seeberger, Sarah J Anderson, Cara E Ellis, Telford Y Yeung, Gregory S Korbutt
AIM: To minimize the expansion of pancreatic mesenchymal cells in vitro and confirm that β-cell progenitors reside within the pancreatic epithelium. METHODS: Due to mesenchymal stem cell (MSC) expansion and overgrowth, progenitor cells within the pancreatic epithelium cannot be characterized in vitro, though β-cell dedifferentiation and expansion of MSC intermediates via epithelial-mesenchymal transition (EMT) may generate β-cell progenitors. Pancreatic epithelial cells from endocrine and non-endocrine tissue were expanded and differentiated in a novel pancreatic epithelial expansion medium supplemented with growth factors known to support epithelial cell growth (dexamethasone, epidermal growth factor, 3,5,3'-triiodo-l-thyronine, bovine brain extract)...
February 15, 2014: World Journal of Diabetes
https://www.readbyqxmd.com/read/24504462/the-temporal-and-hierarchical-control-of-transcription-factors-induced-liver-to-pancreas-transdifferentiation
#3
Dana Berneman-Zeitouni, Kfir Molakandov, Marina Elgart, Eytan Mor, Alessia Fornoni, Miriam Ramírez Domínguez, Julie Kerr-Conte, Michael Ott, Irit Meivar-Levy, Sarah Ferber
Lineage-specific transcription factors (TFs) display instructive roles in directly reprogramming adult cells into alternate developmental fates, in a process known as transdifferentiation. The present study analyses the hypothesis that despite being fast, transdifferentiation does not occur in one step but is rather a consecutive and hierarchical process. Using ectopic expression of Pdx1 in human liver cells, we demonstrate that while glucagon and somatostatin expression initiates within a day, insulin gene expression becomes evident only 2-3 days later...
2014: PloS One
https://www.readbyqxmd.com/read/21082287/differentiating-of-banked-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-into-insulin-secreting-cells
#4
Pham Van Phuc, Truong Hai Nhung, Dang Thi Tung Loan, Doan Chinh Chung, Phan Kim Ngoc
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) are multipotent cells. They are able to differentiate into functional cells from not only mesoderm but also endoderm. Many researches showed that cells derived from fresh human UCB could transdifferentiate into insulin-secreting cells. In this study, transdifferentiating potential of cryopreserved human UCB-derived MSCs into insulin-secreting cell was investigated. Fresh human UCB was enriched the mononuclear cells by Ficoll-Paque centrifugation...
January 2011: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/17979180/conversion-of-immortal-liver-progenitor-cells-into-pancreatic-endocrine-progenitor-cells-by-persistent-expression-of-pdx-1
#5
Cai-Xia Jin, Wen-Lin Li, Fang Xu, Zhen H Geng, Zhi-Ying He, Juan Su, Xin-Rong Tao, Xiao-Yan Ding, Xin Wang, Yi-Ping Hu
The conversion of expandable liver progenitor cells into pancreatic beta cells would provide a renewable cell source for diabetes cell therapy. Previously, we reported the establishment of liver epithelial progenitor cells (LEPCs). In this work, LEPCs were modified into EGFP/Pdx-1 LEPCs, cells with stable expression of both Pdx-1 and EGFP. Unlike previous work, with persistent expression of Pdx-1, EGFP/Pdx-1 LEPCs acquired the phenotype of pancreatic endocrine progenitor cells rather than giving rise to insulin-producing cells directly...
May 1, 2008: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/15367896/redox-mediated-enrichment-of-self-renewing-adult-human-pancreatic-cells-that-possess-endocrine-differentiation-potential
#6
Katrina D Linning, Mei-Hui Tai, Burra V Madhukar, C C Chang, Donald N Reed, Sarah Ferber, James E Trosko, L Karl Olson
OBJECTIVES: The limited availability of transplantable human islets has stimulated the development of methods needed to isolate adult pancreatic stem/progenitor cells capable of self-renewal and endocrine differentiation. The objective of this study was to determine whether modulation of intracellular redox state with N-acetyl-L-cysteine (NAC) would allow for the propagation of pancreatic stem/progenitor cells from adult human pancreatic tissue. METHODS: Cells were propagated from human pancreatic tissue using a serum-free, low-calcium medium supplemented with NAC and tested for their ability to differentiate when cultured under different growth conditions...
October 2004: Pancreas
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