keyword
MENU ▼
Read by QxMD icon Read
search

Cancer prostatic

keyword
https://www.readbyqxmd.com/read/29474983/an-in-depth-evaluation-of-the-validity-and-logistics-surrounding-the-testing-of-ar-v7-mrna-expression-in-circulating-tumor-cells
#1
Anieta M Sieuwerts, Bianca Mostert, Michelle van der Vlugt-Daane, Jaco Kraan, Corine Beaufort, Mai Van, Wendy J C Prager, Bram De Laere, Nick Beije, Paul Hamberg, Hans M Westgeest, Metin Tascilar, Luc Y Dirix, Wendy Onstenk, Ronald de Wit, Martijn P Lolkema, Ron H J Mathijssen, John W M Martens, Stefan Sleijfer
Recent reports have emphasized the clinical relevance of detecting the androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to measure AR-V7 by RT-qPCR in RNA isolated from CellSearch-enriched CTCs to provide an AR-V7 positive/negative score in a clinically acceptable time range. CellSearch-enirched CTCs from metastatic castration-resistant prostate cancer patients were characterized by RT-qPCR. After optimization it was prospectively tested whether it was possible to report the AR-V7 status within 11 days (PRELUDE study)...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29474846/diagnostic-accuracy-of-mpmri-and-fusion-guided-targeted-biopsy-evaluated-by-transperineal-template-saturation-prostate-biopsy-for-the-detection-and-characterization-of-prostate-cancer
#2
Ashkan Mortezavi, Olivia Märzendorfer, Olivio F Donati, Gianluca Rizzi, Niels J Rupp, Marian S Wettstein, Oliver Gross, Tullio Sulser, Thomas Hermanns, Daniel Eberli
PURPOSE: To evaluate the diagnostic accuracy of mpMRI and mpMRI / transrectal ultrasound (TRUS) fusion-guided targeted biopsy (FTB) against transperineal template saturation prostate biopsy (TTSPB) for the detection of prostate cancer (PCa). PATIENTS AND METHODS: Retrospective analysis of 415 men consecutively presenting for prostate biopsy between 11/2014 and 9/2016 at our tertiary care centre. MpMRI (3-Tesla, without endorectal coil) was performed followed by TTSPB with the BiopSee® fusion system...
February 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474521/ethnic-differences-in-tgf%C3%AE-signaling-pathway-may-contribute-to-prostate-cancer-health-disparity
#3
Bethtrice Elliott, DeAdra L Zackery, Vanessa A Eaton, Re'Josef T Jones, Fisseha Abebe, Camille C Ragin, Shafiq A Khan
Epidemiological studies show that the incidence and mortality rates of prostate cancer (PCa) are significantly higher in African-American (AA) men when compared to Caucasian (CA) men in the US. Transforming growth factor β (TGFβ) signaling pathway is linked to health disparities in African-Americans. Recent studies suggest a role of TGFβ3 in cancer metastases and its effect on the migratory and invasive behavior; however, its role in prostate cancer in African American men has not been studied. We determined the circulating levels of TGFβ3 in AA and CA men diagnosed with PCa using ELISA...
February 21, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29474196/adenocarcinoma-prostate-with-neuroendocrine-differentiation-potential-utility-of-18f-fdg-pet-ct-and-68ga-dotanoc-pet-ct-over-68ga-psma-pet-ct
#4
Girish Kumar Parida, Sarthak Tripathy, Shreya Datta Gupta, Abhinav Singhal, Rakesh Kumar, Chandrasekhar Bal, Shamim Ahmed Shamim
Ga-PSMA PET/CT is the upcoming imaging modality for staging, restaging and response assessment of prostate cancer. However, due to neuroendocrine differentiation in some of patients with prostate cancer, they express somatostatin receptors instead of prostate specific membrane antigen. This can be exploited and other modalities like Ga-DOTANOC PET/CT and F-FDG PET/CT should be used in such cases for guiding management. We hereby discuss a similar case of 67-year-old man of adenocarcinoma prostate with neuroendocrine differentiation, which shows the potential pitfall of Ga-PSMA PET/CT imaging and benefit of Ga-DOTANOC PET/CT and F-FDG PET/CT in such cases...
February 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29474096/theranostic-radiopharmaceuticals-established-agents-in-current-use
#5
James R Ballinger
Although use of the term "theranostic" is relatively recent, the concept goes back to the earliest days of nuclear medicine, with the use of radioiodine for diagnosis and therapy of benign and malignant thyroid disease being arguably the most successful molecular radiotherapy in history. A diagnostic scan with123 I-,124 I-, or a low activity of131 I-iodide is followed by therapy with high activity131 I-iodide. Similarly, adrenergic tumours such as phaeochromocytoma and neuroblastoma can be imaged with123 I-metaiodobenzylguanidine (MIBG) and treated with131 I-MIBG...
February 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29474071/identification-of-gibberellic-acid-derivatives-that-deregulate-cholesterol-metabolism-in-prostate-cancer-cells
#6
Folake A Egbewande, Martin C Sadowski, Claire Levrier, Kaylyn D Tousignant, Jonathan M White, Mark J Coster, Colleen C Nelson, Rohan A Davis
The naturally occurring pentacyclic diterpenoid gibberellic acid (1) was used in the generation of a drug-like amide library using parallel-solution-phase synthesis. Prior to the synthesis, a virtual library was generated and prioritized based on drug-like physicochemical parameters such as log P, hydrogen bond donor/acceptor counts, and molecular weight. The structures of the synthesized analogues (2-13) were elucidated following analysis of the NMR, MS, UV, and IR data. Compound 12 afforded crystalline material, and its structure was confirmed by X-ray crystallographic analysis...
February 23, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29473992/radical-prostatectomy-and-the-effect-of-close-surgical-margins-results-from-the-search-database
#7
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
https://www.readbyqxmd.com/read/29473938/shared-decision-making-for-prostate-cancer-screening-and-treatment-a-systematic-review-of-randomised-controlled-trials
#8
Nahara Anani Martínez-González, Andreas Plate, Oliver Senn, Stefan Markun, Thomas Rosemann, Stefan Neuner-Jehle
INTRODUCTION: Men facing prostate cancer screening and treatment need to make critical and highly preference-sensitive decisions that involve a variety of potential benefits and risks. Shared decision-making (SDM) is considered fundamental for "preference-sensitive" medical decisions and it is guideline-recommended. There is no single definition of SDM however. We systematically reviewed the extent of SDM implementation in interventions to facilitate SDM for prostate cancer screening and treatment...
February 23, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29473536/-dermatomyositis-as-a-paraneoplastic-syndrome
#9
M M Wennekers, M Appelman, W F van der Weele
BACKGROUND: Dermatomyositis is an idiopathic inflammatory myopathy with an incidence of 1 in 100,000. Clinically, it features typical skin abnormalities and muscle weakness. In a subset of cases an underlying malignancy may be present; in such instances the term paraneoplastic syndrome is used. CASE DESCRIPTION: We saw a 75-year-old male with progressive skin abnormalities, especially on the chest and hands. In addition, he experienced weakness in his arms and legs...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29473377/the-correlation-between-biological-activity-and-diffusion-weighted-mr-imaging-and-adc-value-in-cases-with-prostate-cancer
#10
Bedriye Koyuncu Sokmen, Dogukan Sokmen, Nese Ucar, Huseyin Ozkurt, Abdulmuttalip Simsek
PURPOSE: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. METHODS: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473374/the-association-between-prostatitis-and-prostate-cancer-systematic-review-and-meta-analysis
#11
Gianpaolo Perletti, Elena Monti, Vittorio Magri, Tommaso Cai, Anne Cleves, Alberto Trinchieri, Emanuele Montanari
OBJECTIVE: The main outcome of this review was the association between a history of clinical chronic prostatitis (NIH category II or III) and a histologically confirmed diagnosis of prostate cancer. MATERIALS AND METHODS: Crude odds ratios and 95% confidence intervals (CI) were calculated to analyze dichotomous data. For analysis of pooled data we adopted a random-effects model and the inverse variance weighing method. Heterogeneity was assessed by calculating the I2 value...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473373/medical-management-in-locally-advanced-and-metastatic-prostate-cancer-does-changes-in-treatment-policy-have-any-specific-effect-on-psa-levels
#12
Murat Bagcioglu, Cristian Surcel, Serkan Ozcan, Cristian Mirvald, Mehmet Ali Karagoz, Mert Ali Karadag, Emre Huri, Kemal Sarica
OBJECTIVE: Androgen deprivation therapy (ADT) is commonly used as a first-line treatment for locally advanced and metastatic prostatic cancer (Pca). There is no consensus about which alternative treatment should be used after the failure of initial ADT. We aimed to investigate the effect of changes in treatment on PSA and testosterone levels. MATERIAL AND METHODS: A total of 120 patients with an established diagnosis of either locally advanced or metastatic Pca in two different centers...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473212/demographic-psychosocial-and-behavioral-associations-with-cancer-screening-among-a-homeless-population
#13
Lovoria B Williams, Amber McCall, Stephen W Looney, Thomas Joshua, Martha S Tingen
BACKGROUND: Although cancer incidence and mortality is declining, cancer remains among the leading causes of death in the United States. Research shows that cancer morbidity and mortality can be reduced by early detection. Yet, both cancer risks and screening behavior remain understudied in the homeless population. METHODS: Researchers conducted a cross-sectional survey of homeless individuals (n = 201). The analysis describes the demographic, psychosocial, and behavioral associations with cancer screenings and knowledge of the lung cancer screening recommendation...
February 23, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29473182/the-androgen-receptor-malignancy-shift-in-prostate-cancer
#14
REVIEW
Ben T Copeland, Sumanta K Pal, Eric C Bolton, Jeremy O Jones
BACKGROUND: Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However, once prostate cells are transformed, the AR is necessary for the proliferation and survival of the malignant cells. This change in AR function appears to occur in nearly every prostate cancer. We have termed this the AR malignancy shift. METHODS: In this review, we summarize the current knowledge of the AR malignancy shift, including the DNA-binding patterns that define the shift, the transcriptome changes associated with the shift, the putative drivers of the shift, and its clinical implications...
February 23, 2018: Prostate
https://www.readbyqxmd.com/read/29473179/does-docetaxel-prolong-survival-of-patients-with-non-metastatic-castration-resistant-prostate-cancer
#15
Kagenori Ito, Takahiro Kimura, Hajime Onuma, Ryuji Tabata, Tatsuya Shimomura, Kenta Miki, Masayuki Tomita, Shin Egawa
BACKGROUND: Guidelines define docetaxel as a first-line therapeutic option for metastatic castration-resistant prostate cancer (mCRPC). However, the role of docetaxel in non-metastatic castration-resistant prostate cancer (nmCRPC) has not been fully investigated. The aim of this retrospective study was to evaluate the potential role of docetaxel in nmCRPC. Clinical outcomes including overall survival were compared between CRPC patients who had docetaxel introduced while in nonmetastatic versus metastatic diseases...
February 23, 2018: Prostate
https://www.readbyqxmd.com/read/29472629/indication-to-pelvic-lymph-nodes-dissection-for-prostate-cancer-the-role-of-multiparametric-magnetic-resonance-imaging-when-the-risk-of-lymph-nodes-invasion-according-to-briganti-updated-nomogram-is-5
#16
Francesco Porpiglia, Matteo Manfredi, Fabrizio Mele, Riccardo Bertolo, Enrico Bollito, Dario Gned, Agostino De Pascale, Filippo Russo, Roberto Passera, Cristian Fiori, Stefano De Luca
BACKGROUND: The Briganti updated nomogram (BN) is the most popular predictive model aiming to predict the presence of lymph node invasion (LNI) in patients with prostate cancer (PCa), but it lacks information obtained by preoperative imaging. The primary aim of the study was to evaluate the role of multiparametric prostate magnetic resonance imaging (mp-MRI) in the indication to perform pelvic lymph nodes dissection (PLND) or not in patients with risk of LNI according to BN below 5%. METHODS: Since March 2012 and September 2016, 310 patients who underwent a preoperative mp-MRI for staging purpose and subsequent robot-assisted extended PLND (RAEPLND) were retrospectively evaluated...
February 22, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29472144/is-68-ga-prostate-specific-membrane-antigen-ligand-positron-emission-tomography-computed-tomography-ready-to-simplify-the-conundrum-of-biochemically-recurrent-prostate-cancer
#17
EDITORIAL
Thenappan Chandrasekar, Piet Ost, Derya Tilki
No abstract text is available yet for this article.
February 19, 2018: European Urology
https://www.readbyqxmd.com/read/29472083/quantifying-the-performance-of-two-different-types-of-commercial-software-programs-for-3d-patient-dose-reconstruction-for-prostate-cancer-patients-machine-log-files-vs-machine-log-files-with-epid-images
#18
Noriyuki Kadoya, Yoshio Kon, Yoshiki Takayama, Takuya Matsumoto, Naoki Hayashi, Yoshiyuki Katsuta, Kengo Ito, Takahito Chiba, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We clarified the reconstructed 3D dose difference between two different commercial software programs (Mobius3D v2.0 and PerFRACTION v1.6.4). Five prostate cancer patients treated with IMRT (74 Gy/37 Fr) were studied. Log files and cine EPID images were acquired for each fraction. 3D patient dose was reconstructed using log files (Mobius3D) or log files with EPID imaging (PerFRACTION). The treatment planning dose was re-calculated on homogeneous and heterogeneous phantoms, and log files and cine EPID images were acquired...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29471970/the-accuracy-and-precision-of-kilovoltage-intrafraction-monitoring-kim-six-degree-of-freedom-prostate-motion-measurements-during-patient-treatments
#19
Jung-Ha Kim, Doan T Nguyen, Jeremy T Booth, Chen-Yu Huang, Todsaporn Fuangrod, Per Poulsen, Ricky O'Brien, Vincent Caillet, Thomas Eade, Andrew Kneebone, Paul Keall
BACKGROUND AND PURPOSE: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. MATERIAL AND METHODS: Real-time 6DoF prostate motion was acquired using KIM for 14 prostate cancer patients (377 fractions). KIM outputs the 6DoF prostate motion, combining 3D translation and 3D rotational motion information relative to its planning position...
February 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29471894/mir-615-inhibits-prostate-cancer-cell-proliferation-and-invasion-by-directly-targeting-cyclin-d2
#20
Fengyu Huang, Hongjun Zhao, Zhaojin Du, Hong Jiang
Previous studies have reported that miR-615 exerts a tumor suppressor in some tumors, such as esophageal squamous cellcarcinoma and non-small cell lung cancer. However, the role of miR-615 in prostate cancer cells has not been defined. Here, we found that miR-615 was downregulated in prostate cancer tissues and cell lines. And overexpression of miR-615 in PC-3 cells significantly inhibited cellular proliferation, migration and invasion. Moreover, overexpression of miR-615 delayed tumor growth in vivo. In term of mechanism, we found that Cyclin D2 is a target gene of miR-615 in prostate cancer...
February 22, 2018: Oncology Research
keyword
keyword
106384
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"