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https://www.readbyqxmd.com/read/29682893/early-intervention-in-scar-management-and-cutaneous-burns-with-autologous-platelet-rich-plasma
#1
Aura Ruiz, Daniel Cuestas, Paula Garcıa, Jose Quintero, Yency Forero, Ingrid Galvis, Oscar Velasquez
Burn management options are controversial and a multiple-handled issue. However, platelet-rich plasma is gaining interest in several medical fields. Dermatologist worldwide are already publishing some reports about its benefits and personal experiences in their practices. A 40-year-old female with a second-degree burn by VASER-type liposculpture was treated with platelet-rich plasma and followed up for 10 months. After treatment, she showed rapid improvement with an adequate cicatrization results. Some studies suggest that the use of platelet-rich plasma which contains cytokines and growth factors that participate in cellular repair and cellular differentiation, thus improving healing time and re-epithelization...
April 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29682259/effects-of-the-application-of-high-pressure-oxygen-on-the-treatment-of-periodontal-disease-in-diabetic-patients
#2
S Sabatini, M Ricci, V Candotto, D Lauritano, G M Nardi
Purpose: In this study we wanted to observe the improvement in the healing of periodontal tissues in a group of diabetic patients treated with traditional methods compared to another group treated with the addition of oxygen.The potential of oxygen has long been known in the field of plastic surgery, where it is used to treat burns and skin lesions. Materials and methods: This study consists in a split mouth study which involved 30 patients. We carefully treated them with periodontal therapy using manual and mechanical instrumentation...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29677134/modeling-skin-injury-from-hot-rice-porridge-spills
#3
Torgrim Log
The present work analyzes skin burns from spills of hot rice and milk products. The traditional Norwegian rice porridge serves as an example. By testing spills on objects emulating an arm, it was concluded that spills were seldom thinner than 3 mm, and stayed in place due to the viscosity of the porridge for more than one minute. The Pennes bioheat equation was solved numerically for such spills, including heat conduction to the skin and convective heat losses from the porridge surface. Temperatures were analyzed in the porridge and skin layers, and the resulting skin injury was calculated based on the basal layer temperature...
April 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29673562/candida-tropicalis-burn-wound-sepsis-a-series-of-histopathology-confirmed-cases
#4
Chunjie Fan, Qingfen Tian, Guobao Huang, Lei Zhang, Qiuhe Wu, Keyan Zhang
Fungal infection in severely burned patients is a serious problem due to various factors, such as the extensive application of antibiotics. In this study, we report on the course of severely burned patients with Candida tropicalis burn wound sepsis. Five such cases were reviewed. The patients were treated with itraconazole intravenously and simultaneous antibiotics to prevent bacterial infections. In addition, dermabrasion was used to excise the eschar and the wound surface was covered immediately with dermatoplasty...
April 16, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29673408/long-term-scar-quality-after-hydrosurgical-versus-conventional-debridement-of-deep-dermal-burns-hycon-trial-study-protocol-for-a-randomized-controlled-trial
#5
Catherine M Legemate, Harold Goei, Esther Middelkoop, Irma M M H Oen, Tim H J Nijhuis, Kelly A A Kwa, Paul P M van Zuijlen, Gerard I J M Beerthuizen, Marianne K Nieuwenhuis, Margriet E van Baar, Cornelis H van der Vlies
BACKGROUND: Deep dermal burns require tangential excision of non-viable tissue and skin grafting to improve wound healing and burn-scar quality. Tangential excision is conventionally performed with a knife, but during the last decade hydrosurgery has become popular as a new tool for tangential excision. Hydrosurgery is generally thought to be a more precise and controlled manner of burn debridement leading to preservation of viable tissue and, therefore, better scar quality. Although scar quality is considered to be one of the most important outcomes in burn surgery today, no randomized controlled study has compared the effect of these two common treatment modalities with scar quality as a primary outcome...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29668985/efficacy-of-a-gel-containing-polihexanide-and-betaine-in-deep-partial-and-full-thickness-burns-requiring-split-thickness-skin-grafts-a-non-comparative-clinical-study
#6
Jurij Kiefer, Kamran Harati, Wibke Müller-Seubert, Sebastian Fischer, Benjamin Ziegler, Björn Behr, Jochen Gille, Ulrich Kneser, Marcus Lehnhardt, Adrien Daigeler, Adrian Dragu
Background: Despite overall advances in burn therapy, wound infection remains one of the leading causes of morbidity and mortality in patients with severe burn injuries. This prospective, multicenter, non-comparative clinical trial was conducted to assess the efficacy and safety of Prontosan® Wound Gel X (PWX), a gel containing polihexanide and betaine, for moistening and cleansing in deep tissue burn wounds requiring split-thickness skin grafting. Methods: Patients with deep partial or full thickness burn wounds requiring split-thickness skin grafting were treated with the gel to evaluate its tolerability and safety as well as graft take and the healing of the skin graft...
April 14, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29664017/specialized-fibroblast-differentiated-states-underlie-scar-formation-in-the-infarcted-mouse-heart
#7
Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G Boyer, Ronald J Vagnozzi, Bryan D Maliken, Michelle A Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C Blaxall, Jeffery D Molkentin
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29663582/the-skin-microbiome-of-wound-scars-and-unaffected-skin-in-patients-with-moderate-to-severe-burns-in-the-subacute-phase
#8
Su-Hsun Liu, Yhu-Chering Huang, Leslie Y Chen, Shu-Chuan Yu, Hsiao-Yun Yu, Shiow-Shuh Chuang
Although studies on skin microbiome of acute and chronic wounds abound, evidence on newly-built microbial communities of subacute wounds remains scant. To characterize the skin microbiome of recently-healed (scarred) burn wounds in relation to unaffected skin surfaces, we collected weekly swabs from patients with moderate to severe burns in the 3rd postburn month for 4 weeks in 2015. We performed skin type (moist, dry, and oily)-matched comparisons within six burn patients (43 pairs of swabs) and with 13 skin-healthy, control patients (22 pairs of samples) using 16S ribosomal RNA (rRNA) gene sequencing results...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29662775/relationship-between-heterotopic-ossification-and-traumatic-brain-injury-why-severe-traumatic-brain-injury-increases-the-risk-of-heterotopic-ossification
#9
REVIEW
Huan Huang, Wen-Xiang Cheng, Yi-Ping Hu, Jian-Hai Chen, Zheng-Tan Zheng, Peng Zhang
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29656662/beneficial-effects-of-salvia-miltiorrhiza-in-the-healing-of-burn-wounds-an-experimental-study-in-rats
#10
Fatih Irmak, Sevgi Kurt Yazar, Serhat Selami Şirvan, Merdan Serin, Ayşim Özağarı, Ayşin Karasoy Yeşilada
INTRODUCTION: Burn healing is a complicated process and very few treatments can positively alter its effects. The aim of this study was to investigate the effects Salvia miltiorrhiza (SM -Danshen), a traditional Chinese medicine, on burn wound healing. MATERIAL AND METHODS: Twenty rats were included in this study and divided into two groups. 3 × 2 cm wide burn areas were created in the dorsal skin of all the animals with thermal contact. Intraoral 1 ml/day saline and 1 g/kg/day SM were given in control and experiment groups, respectively...
April 14, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29655989/in-vivo-migration-of-mesenchymal-stem-cells-to-burn-injury-sites-and-their-therapeutic-effects-in-a-living-mouse-model
#11
Eun Jung Oh, Ho Won Lee, Senthilkumar Kalimuthu, Tae Jung Kim, Hyun Mi Kim, Se Hwan Baek, Liya Zhu, Ji Min Oh, Seung Hyun Son, Ho Yun Chung, Byeong-Cheol Ahn
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising therapeutic strategy for tissue regeneration and repair. In this study, we non-invasively monitored the tracking of MSCs toward burn injury sites using MSCs expressing firefly luciferase (Fluc) gene in living mice, and evaluated the effects of the MSCs at the injury site. Murine MSCs co-expressing Fluc and green fluorescent protein (GFP) were established using a retroviral system (referred to as MSC/Fluc). To evaluate the ability of MSC migration toward burn injury sites, cutaneous burn injury was induced in the dorsal skin of mice...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29651853/oleogel-s10-to-accelerate-healing-of-donor-sites-monocentric-results-of-phase-iii-clinical-trial
#12
B Lipový, M Fiamoli, R Mager, Z Jelínková, J Jarkovský, Z Chaloupková, J Holoubek, I Suchánek, P Brychta
MATERIAL AND METHODS: Oleogel-S10, an ointment containing betulin-rich triterpene dry extract from birch bark was tested in an open, blindly evaluated, prospective, controlled, randomized multicentre study to improve wound healing in donor sites. The primary endpoint was time to wound closure, and secondary endpoints were scar related measurements at the time of wound closure, and 3 and 12 months after wound closure (POSAS, laser speckle contrast analysis, viscoelastic analysis). RESULTS: We report the results from a single centre (Department of Burns and Reconstructive Surgery, University Hospital Brno) of this phase III clinical trial...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29651394/the-healing-effect-of-sesame-oil-camphor-and-honey-on-second-degree-burn-wounds-in-rat
#13
Reza Vaghardoost, Seyed GholamReza Mousavi Majd, Hamid Tebyanian, Hamid Babavalian, Leila Malaei, Mitra Niazi, Ali Javdani
BACKGROUND: Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline. METHODS: Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651393/wound-healing-potential-of-intermittent-negative-pressure-under-limited-access-dressing-in-burn-patients-biochemical-and-histopathological-study
#14
Honnegowda Thittamaranahalli Muguregowda, Pramod Kumar, Padmanabha Udupa Echalasara Govindarama
BACKGROUND: Malondialdehyde (MDA) is an oxidant that causes damage to membranes, DNA, proteins, and lipids at the cellular level. Antioxidants minimize the effects of oxidants and thus help in formation of healthy granulation tissues with higher level of hydroxyproline and total protein. This study compared the effect of limited access dressing (LAD) with conventional closed dressing biochemically and histopathologically. METHODS: Seventy-two 12-65 years old burn patients with mean wound size of 14 cm2 were divided to two groups of LAD (n=37), and conventional dressing groups (n=35)...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651390/comparison-of-albizia-julibressin-and-silver-sulfadiazine-in-healing-of-second-and-third-degree-burns
#15
Hossein Asgarirad, Aroona Chabra, Mahnaz Rahimnejad, Ahmad Zaghi Hosseinzadeh, Ali Davoodi, Mohammad Azadbakht
BACKGROUND: Large numbers of population suffer from burn annually. The promising treatment of burn has not been identified yet. Albizia julibressin ( A. julibressin ) in Fabaceae family is popular for its antiseptic activity. This prospective study was designed to compare the wound healing effects of A. julibressin gel (AG) with silver sulfadiazine (SSD). METHODS: This single blind clinical trial was performed on 40 patients with second and third degree burns. 20 patients treated with SSD and 20 other patients received A...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651389/the-healing-effect-of-n-hexan-dichloromethane-extract-root-onosma-bulbotrichum-in-second-degree-burns
#16
Aliasghar Hemmati, Forough Namjuyan, Sadegh Yousefi, Gholamreza Housmand, Hossein Khadem Haghighian, Anahita Rezaei
BACKGROUND: Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root Onosma bulbotrichum DC on the second degree burn in rabbit model was investigated. METHODS: Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% O...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649056/topical-aloe-vera-gel-for-accelerated-wound-healing-of-split-thickness-skin-graft-donor-sites-a-double-blind-randomized-controlled-trial-and-systematic-review
#17
Chairat Burusapat, Monlada Supawan, Chatchai Pruksapong, Anont Pitiseree, Chaichoompol Suwantemee
BACKGROUND: Aloe vera has been used to treat wounds since ancient times. However, the efficacy of Aloe vera for burns and split-thickness skin graft (STSG) donor sites are inconclusive. METHODS: A double-blind, randomized, controlled trial was conducted. Patients who underwent STSG harvesting from the thigh were included. STSG donor sites were divided into two groups: Aloe vera group and placebo group. The visual analogue scale (VAS) score evaluated pain and complete epithelialization was assessed...
March 30, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29643795/ocular-injury-due-to-potassium-permanganate-granules
#18
Chareenun Chirapapaisan, Pinnita Prabhasawat, Sabong Srivannaboon, Vatookarn Roongpoovapatr, Piyada Chitsuthipakorn
Purpose: We report a rare case of ocular injury due to potassium permanganate (KMnO4 ) granules in a child. Methods: This is a retrospective case report. Results: A 2-year-old boy was transferred to our emergency room with severe pain in his right eye, inflamed eyelids, and brownish stains on his fingers. Chemical injury was suspected. Copious eye irrigation was immediately performed. Diffuse brownish splotches were then observed at the inferior bulbar conjunctiva...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29629853/-determining-depth-of-burns-using-laser-doppler-imaging
#19
C M Legemate, M J Hop, M K Nieuwenhuis, E Middelkoop, M E van Baar, C H van der Vlies
Early accurate assessment of burn depth is important to determine the optimal treatment of burns (conservative versus surgery). Laser Doppler imaging (LDI) is a technique that allows accurate measurement of burn depth by measuring dermal perfusion. Although it has been demonstrated that LDI led to faster decisions as to whether or not to operate, this has not lead to shorter wound healing time or cost savings in Dutch burn care. LDI is used in all Dutch burn centres. In case of doubt about the depth of a burn in primary or secondary care, referral to a burn centre is advisable...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29623705/centella-asiatica-centellicum%C3%A2-facilitates-the-regular-healing-of-surgical-scars-in-subjects-at-high-risk-of-keloids
#20
Roberto Cotellese, Shu Hu, Gianni Belcaro, Andrea Ledda, Beatrice Feragalli, Mark Dugall, Morio Hosoi, Edmondo Ippolito
BACKGROUND: Formation of scars after surgical incisions requires the proper appositions of elements contributing to the scarring process. The structural rebuilding of damaged tissues is essential in producing a linear scar. The excess of blood, foreign particles, exuberant sutures, necrotic tissue, possible infective agents, as well as the ongoing inflammatory process may produce a non-linear, sometimes painful keloidal scar. Centella asiatica (CA) extracts have been used topically since ancient times for preventing keloids (i...
April 2018: Minerva Chirurgica
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