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Burn healing

Ferdaous Ghrab Ben Djemaa, Khaled Bellassoued, Sami Zouari, Abdelfatteh El Feki, Emna Ammar
Lavandula aspic L. is a strongly aromatic shrub plant of the Lamiaceae family and traditionally used in herbal medicine for the treatment of several skin disorders, including wounds, burns, and ulcers. The present study aimed to investigate the composition and in vitro antioxidant activity of lavender essential oil. In addition, it aimed to evaluate the excision wound healing activity and antioxidant property of a Lavandula aspic L. essential oil formulated in ointment using a rat model. The rats were divided into five groups of six animals each...
October 5, 2016: Journal of Tissue Viability
C M Han
The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Santram Lodhi, Avijeet Jain, Alok Pal Jain, Rajesh Singh Pawar, Abhay Kumar Singhai
OBJECTIVE: Martynia annua L. (M. annua), (Martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. The leaf paste is used topically on Tuberculosis of the lymphatic glands and wounds of domestic animals. Tephrosia purpurea (T. purpurea), (Fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. This study aimed to evaluate the potential wound healing effects of different fractions ofethanol extract of M...
September 2016: Avicenna Journal of Phytomedicine
Yalcin Yontar, Atilla Coruh, Nadire Dinc, Olgun Kontas
Early tangential excision of the burn wound is essential for removal of necrotic tissue and promotion of burn wound healing process. However, the depth of the burn wound is not easily assessed during the tangential excision performed by hand-held dermatomes, and it may be possible to excise unburned vital dermis unnecessarily, which aids in primary epithelization of the burn wound by adnexal structures. We herein present early clinical results of steel wool-aided dermabrasion in patients with deep partial-thickness burns...
October 7, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Betty Laverdet, Dorothée Girard, Audrey Bayout, Nelly Bordeau, Claire Demiot, Alexis Desmoulière
BACKGROUND: Damage to the peripheral nervous system influences wound healing and, after a deep burn, imperfect cutaneous nerve regeneration occurs. A third-degree burn model was developed in rats combined with the use of resiniferatoxin (RTX), known to promote sensory neuropathy. METHODS: Rats were injected intraperitoneally either with RTX or vehicle. A mechanical sensory assay and the hot plate thermal sensory test were performed. The structural integrity of the sciatic nerve was assessed using transmission electron microcopy...
October 12, 2016: Burns: Journal of the International Society for Burn Injuries
Gloria B Chiu, Christos Theophanous, John A Irvine
PURPOSE: To report a case of persistent epithelial defects in a patient with ocular chronic graft-versus-host disease that required coordinated modulation of systemic immunosuppressive treatment and overnight wear of Prosthetic Replacement of the Ocular Surface Ecosystem (BostonSight PROSE, Needham, MA) devices to achieve ocular surface healing. CASE REPORT: The case of a 38-year-old male patient who presented with a 2-year history of ocular chronic graft-versus-host disease, ocular burning, pain, light sensitivity, and a 3-week history of bilateral corneal epithelial defects is presented...
October 12, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Omer Karti, Mehmet Ozgur Zengin, Esat Cinar, Merve Tutuncu, Eyyup Karahan, Asl Celik, Cem Kucukerdonmez
PURPOSE: To study the effect of 1- and 6-hour-delayed corneal collagen cross-linking (CXL) on wound-healing of experimental alkali burns of the cornea. METHODS: Twenty-four albino rabbits were used. Alkali burns were created using 1 M NaOH. The animals were divided randomly into 2 groups: group 1 (control group, n = 6) and group 2 (experimental group, n = 18). The experimental group was further divided into 3 subgroups as follows: group 2A, untreated (non-CXL) subgroup; group 2B, 1-hour-delayed CXL treatment subgroup; and group 2C, 6-hour-delayed CXL treatment subgroup...
October 12, 2016: Cornea
Alexandre Lamaro Cardoso, Maria Márcia Bachion, Júlia de Miranda Morais, Marcelo Silva Fantinati, Vera Lúcia Lima de Almeida, Ruy Souza Lino
PURPOSE: To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats. METHODS: Animals were divided into two groups: 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was treated with injections of SVF prepared from adipose tissue extracted from an animal donor...
September 2016: Acta Cirúrgica Brasileira
Mariko Moriyama, Hiroyuki Moriyama, Junki Uda, Hirokazu Kubo, Yuka Nakajima, Arisa Goto, Junji Akaki, Ikuyo Yoshida, Nobuya Matsuoka, Takao Hayakawa
Aloe has been used as a folk medicine because it has several important therapeutic properties. These include wound and burn healing, and Aloe is now used in a variety of commercially available topical medications for wound healing and skin care. However, its effects on epidermal keratinocytes remain largely unclear. Our data indicated that both Aloe vera gel (AVG) and Cape aloe extract (CAE) significantly improved wound healing in human primary epidermal keratinocytes (HPEKs) and a human skin equivalent model...
2016: PloS One
Pan-Xi Yu, Wen-Qi Diao, Zuo-Liang Qi, Jing-Long Cai
<strong>Objective</strong> To explore the effects of dermabrasion combined with ReCell(®) on large superficial facial scars caused by burn, trauma and acnes.<strong>Methods</strong> Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell(®). According to the etiology, patients were classified into post-burning group (n=5), post-traumatic group (n=7) and post-acne group (n=7). Fifteen patients completed the follow-ups, 5 patients in each group...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
Carolina Schencke, Adriana Vasconcellos, Cristian Sandoval, Paulina Torres, Francisca Acevedo, Mariano Del Sol
BACKGROUND: In the context of the search for cost-efficient treatments, Ulmo (Eurcyphia cordifolia) honey is an excellent alternative for treating burn wounds and could have a profound medical, social, and economic impact. Ascorbic acid is an enzymatic co-factor necessary for the synthesis of collagen and the proliferation of fibroblasts and has been proposed as a coadjuvant to strengthen the healing effects of honey. The aim of this work was to evaluate by morphometric studies the healing wounds caused by burns treated with Ulmo honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus)...
2016: Burns and trauma
Fei Chang, Dasheng Cheng, Mingyuan Qian, Wei Lu, Huatao Li, Hongtai Tang, Zhaofan Xia
BACKGROUND As patients with thoracic duct injuries often suffer from severe local soft tissue defects, integrated surgical treatment is needed to achieve damage repair and wound closure. However, thoracic duct chylous fistula is rare in burn patients, although it typically involves severe soft tissue damage in the neck or chest. CASE REPORT A 32-year-old male patient fell after accidentally contacting an electric current (380 V) and knocked over a barrel of sulfuric acid. The sulfuric acid continuously poured onto his left neck and chest, causing combined electrical and sulfuric acid burn injuries to his anterior and posterior torso, and various parts of his limbs (25% of his total body surface area)...
October 11, 2016: American Journal of Case Reports
Jun Yeon Park, Jin Ho Kwak, Ki Sung Kang, Eun Bee Jung, Dong-Soo Lee, Sanghyun Lee, Yujung Jung, Ki Hyun Kim, Gwi Seo Hwang, Hye Lim Lee, Noriko Yamabe, Su-Nam Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Jawoongo is a traditional drug ointment (with a traditional botanic formula) used for the treatment of burns and wounds in Korea. One of the components of Jawoongo is Lithospermi Radix (LR, the dried root of Lithospermum erythrorhizon Siebold & Zucc., also known as Zicao or Gromwell), which contains deoxyshikonin and its derivatives. OBJECTIVE: The aim of the present study was to investigate the effects of deoxyshikonin on wound healing...
October 7, 2016: Journal of Ethnopharmacology
Matthew P Rowan, Darrick J Beckman, Julie A Rizzo, Claire L Isbell, Christopher E White, Stephen M Cohn, Kevin K Chung
BACKGROUND: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients. METHODS: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients...
October 4, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Sarah Lonie, Paul Baker, Rodrigo P Teixeira
INTRODUCTION: Scald burns, which heal in less than 14 days, are seen to be at low risk of hypertrophic scar (HTS) formation. Consequently surgery is usually reserved for scalds likely to take more than 14 days to heal. With the use of silver based dressings over the past few years, anecdotally, we have observed a tendency to improved healing of scalds with conservative management and reduced need for surgical intervention. We aimed to investigate the effect of overall healing time of paediatric scalds on HTS formation over a five-year period (2011-15)...
October 1, 2016: Burns: Journal of the International Society for Burn Injuries
Celeste C Finnerty, Marc G Jeschke, Ludwik K Branski, Juan P Barret, Peter Dziewulski, David N Herndon
Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now up to 70% of patients develop hypertrophic scars after burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. Approaches to optimise healing potential of burn wounds use targeted wound care and surgery to minimise the development of hypertrophic scarring. Such approaches often fail, and modulation of the established scar is continued although the optimal indication, timing, and combination of therapies have yet to be established...
October 1, 2016: Lancet
Manuel Held, Anne-Sophie Engelke, Dascha Sophie Tolzmann, Afshin Rahmanian-Schwarz, Hans-Eberhard Schaller, Jens Rothenberger
INTRODUCTION: There is a high prevalence of superficial wounds such as partial-thickness burns. Treatment of these wounds frequently includes temporary application of wound dressings. The aim of this study was to compare a newly developed collagen matrix with commonly used temporary skin dressings for treatment of partial-thickness skin defects. MATERIALS AND METHODS: Through a skin dermatome, 42 standardized superficial skin defects were generated on the back of 28 adult male Lewis rats...
September 2016: Wounds: a Compendium of Clinical Research and Practice
Lingfeng Wang, Chunguang Hao, Biao Zhou, Xue Fu, Junliang Li, Zhigang Wang, Zhidong Rong
INTRODUCTION: This study investigated the application of selective sheepskin acellular dermal matrix (ADM), combined with the anticoagulant heparin, in the wound-healing treatment of deep second-degree burns (DSDB). METHODS: A DSDB model was established, and the test animals were randomly divided into 4 groups: iodophor gauze (IG), pig ADM (PA), selective sheepskin ADM (SSA), and heparinized selective sheepskin ADM (HSSA).The microcirculation of the wound surface, pathological structures, healing rates, and fibroblast apoptosis rates were observed at different times in each group...
September 29, 2016: Wounds: a Compendium of Clinical Research and Practice
Fatemeh Vafi, Roodabeh Bahramsoltani, Mohammad Abdollahi, Azadeh Manayi, Amir Hossein Abdolghaffari, Nasrin Samadi, Gholamreza Amin, Gholamreza Hassanzadeh, Hossein Jamalifar, Maryam Baeeri, Mohammad Heidari, Mahnaz Khanavi
OBJECTIVE: Burns are complicated traumatic injuries caused by several physical or chemical factors. Plants with a wide range of secondary metabolites, with valuable properties like antioxidant and anti-inflammatory activities, can be a promising source of wound healing agents. MATERIALS AND METHODS: Effects of hydromethanolic extracts of Lythrum salicaria and Hypericum scabrum, individually and in combination, were assessed in second-degree burn wounds in rats in comparison to a white oleaginous base (negative control) and silver sulfadiazine (positive control)...
September 29, 2016: Wounds: a Compendium of Clinical Research and Practice
Moti Harats, Amnon Lam, Michael Maller, Rachel Kornhaber, Josef Haik
BACKGROUND: Cold plasma skin welding is a novel technology that bonds skin edges through soldering without the use of synthetic materials or conventional wound approximation methods such as sutures, staples, or skin adhesives. The cold plasma welding system uses a biological solder applied to the edges of a skin incision, followed by the application of cold plasma energy. The objectives of this study were to assess the feasibility of a cold plasma welding system in approximating and fixating skin incisions compared with conventional methods and to evaluate and define optimal plasma welding parameters and histopathological tissue response in a porcine model...
September 29, 2016: Wounds: a Compendium of Clinical Research and Practice
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