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Burn healing

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https://www.readbyqxmd.com/read/29244970/maggot-debridement-therapy-for-an-electrical-burn-injury-with-instructions-for-the-use-of-lucilia-sericata-larvae
#1
A Nasoori, R Hoomand
OBJECTIVE: Maggot debridement therapy (MDT) has proved an efficient and reliable approach for wound healing. We explain the use of maggots with a stepwise procedure for conducting MDT in a patient with severe and large electrical wounds. METHOD: We captured the flies of Lucilia sericata from the natural environment, Alborz, Iran, and reared them in netted cages. The eggs obtained from the flies were disinfected with chloramine, and then were incubated on culture medium...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29240641/low-dose-insulin-as-an-anti-scarring-therapy-in-breast-surgery-a-randomised-controlled-trial
#2
Marc-James Hallam, Elizabeth Pitt, Alexis Thomas, Charles Nduka
BACKGROUND: The role of insulin in expediting wound healing is firmly established within the context of major trauma and burns however only limited clinical evidence exists as to its effects upon scar formation. This study aims to build upon previous laboratory work to examine the potential anti-scarring properties of insulin in a clinical environment. METHODS: 91 patients undergoing bilateral aesthetic breast surgeries were recruited to receive low-dose insulin and placebo injections to the medial 3cm of their sub-mammary incisions within the context of a randomised, intra-patient, placebo controlled trial and scar quality was assessed at 3, 6, and 12-month reviews using the Manchester Scar Scale...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29240587/reclaiming-autologous-amputated-tissue-for-limb-salvage-of-a-diabetic-foot-burn-with-underlying-critical-limb-ischemia
#3
Catherine N Tchanque-Fossuo, Andrew M Wishy, Kaitlyn I M West, David L Dawson, Sara E Dahle, John G Carson
BACKGROUND: Diabetes mellitus is a worldwide pandemic that impacts more than 387 million people, with 29 million individuals affected in the United States alone. Diabetic patients have a 25% lifetime risk of developing a diabetic foot ulcer (DFU). Having a DFU is associated with a risk of recurrence approaching 70%. In addition, 1 in 6 patients with DFU will have a lower-limb amputation, with an associated increase in mortality ranging from 47% to 70%. Therefore, limb salvage is critical in patients with DFU...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29218280/the-effect-of-lithospermum-officinale-silver-sulfadiazine-and-alpha-ointments-in-healing-of-burn-wound-injuries-in-rat
#4
Zahra Mohtasham Amiri, Nader Tanideh, Anahita Seddighi, Maral Mokhtari, Masood Amini, Alborz Shakouri Partovi, Amir Manafi, Seyedeh Sara Hashemi, Davood Mehrabani
BACKGROUND: Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS: Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine (SSD), gel base and L. officinale extract, respectively. A hot plate was used for induction of a standard 3rd degree burn wound...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29214186/a-rare%C3%A2-case-of%C3%A2-failed-healing-in-previously-burned-skin%C3%A2-after-a%C3%A2-secondary-burns
#5
Stephen J Goldie, Shaun Parsons, Hana Menezes, Andrew Ives, Heather Cleland
Background: Patients presenting with large surface area burns are common in our practice; however, patients with a secondary large burn on pre-existing burn scars and grafts are rare and not reported. Case presentation: We report on an unusual case of a patient sustaining a secondary large burn to areas previously injured by a burn from a different mechanism. We discuss the potential implications when managing a case like this and suggest potential biological reasons why the skin may behave differently...
2017: Burns and Trauma
https://www.readbyqxmd.com/read/29209994/the-role-of-trypsin-chymotrypsin-in-tissue-repair
#6
REVIEW
Dilip Shah, Kushal Mital
Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues. The tissue repair process can be broadly divided into four continuous and overlapping phases-hemostasis and coagulation, inflammation, proliferation, and remodeling. If the process is interrupted or halted during any stage, it leads to impaired healing and formation of a chronic wound...
December 5, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29199384/low-intensity-led-therapy-658%C3%A2-nm-on-burn-healing-a-series-of-cases
#7
Rauirys Alencar de Oliveira, Luara Lis Barbosa Boson, Seísa Marina Martins Portela, Antônio Luiz Martins Maia Filho, Denyberg de Oliveira Santiago
The objective of this study was to evaluate the effects of LED on burns healing. Five patients with skin burns were submitted to photobiomodulation by LED, GaAsIP diode, (λ 658 nm) with 40 mW, 7 J/cm2 on every other day. Biopsies of burned skin were performed and the healing process was photographed. Patients with bilateral burns were used as self-control, having one limb being irradiated and the contralateral limb irradiated with placebo. The burns treated with LED showed higher epithelization, with keratinocytes and fibroblasts proliferation, increased collagen synthesis, decreased pain, and pruritus...
December 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29198938/outcomes-of-arthroscopic-revision-rotator-cuff-repair-with-acellular-human-dermal-matrix-allograft-augmentation
#8
Eric A Hohn, Blake P Gillette, Joseph P Burns
BACKGROUND: The purpose was to assess the minimum 2-year patient-reported outcomes and failure rate of patients who underwent revision arthroscopic rotator cuff repair augmented with acellular human dermal matrix (AHDM) allograft for repairable retears. METHODS: From 2008-2014, patients who underwent revision rotator cuff repair augmented with AHDM with greater than 2 years' follow-up by a single surgeon were retrospectively reviewed. Data regarding surgical history, demographic characteristics, and medical comorbidities were collected...
November 30, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29180925/marjolin-s-ulcer-in-chronic-wounds-review-of-available-literature
#9
REVIEW
Dariusz Bazaliński, Joanna Przybek-Mita, Beata Barańska, Paweł Więch
Marjolin's ulcer is a rare, aggressive skin cancer developing in scar tissue, chronic ulcers and areas affected by inflammations. Its incidence is estimated to range from 1% to 2% of all burn scars. It most frequently takes the form of squamous cell carcinoma which sometimes is diagnosed during examination of lesions developing in scars and hard-to-heal chronic wounds (pressure sores, leg ulcers). Therapeutic management of Marjolin's ulcer requires well-designed treatment plan to ensure optimal medical care and good quality of life for the patient...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29178668/pseudomonas-aeruginosa-biofilm-hampers-murine-central-wound-healing-by-suppression-of-vascular-epithelial-growth-factor
#10
Hannah Trøstrup, Christian J Lerche, Lars J Christophersen, Kim Thomsen, Peter Ø Jensen, Hans Petter Hougen, Niels Høiby, Claus Moser
Biofilm-infected wounds are clinically challenging. Vascular endothelial growth factor and host defence S100A8/A9 are crucial for wound healing but may be suppressed by biofilms. The natural course of Pseudomonas aeruginosa biofilm infection was compared in central and peripheral zones of burn-wounded, infection-susceptible BALB/c mice, which display delayed wound closure compared to C3H/HeN mice. Wounds were evaluated histopathologically 4, 7 or 10 days post-infection. Photoplanimetry evaluated necrotic areas...
November 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29173148/trends-and-prospects-of-plant-proteases-in-therapeutics
#11
Anastasia V Balakireva, Natalia V Kuznetsova, Anastasia I Petushkova, Lyudmila Savvateeva, Andrey A Zamyatnin
The main function of proteases in any living organism is the cleavage of proteins resulting in the degradation of damaged, misfolded and potentially harmful proteins and therefore providing the cell with amino acids essential for the synthesis of new proteins. Besides this main function, proteases may play an important role as signal molecules and participate in numerous protein cascades to maintain the vital processes of an organism. Plant proteases are no exception to this rule. Moreover, in contrast to human-encoded enzymes, many plant proteases possess exceptional features such as higher stability, unique substrate specificity and a wide pH range for enzymatic activity...
November 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29168896/healing-of-self-inflicted-thermal-injury-of-palatal-mucosa-by-low-level-laser-therapy
#12
Abdul Ahad, Shazra Tasneem, Arundeep Kaur Lamba, Saif Khan
Self-inflicted injury to oral mucosa is a rare entity. These injuries can be premeditated, accidental, or can result from an abnormal habit. These uncommon gingival injuries can sometimes test the clinician's diagnostic abilities as well as treatment planning skills. In conventional treatment, removal of etiology and application of topical drugs is usually sufficient for healing. However, some cases require alternative or adjunctive wound healing methods. Low-level laser therapy (LLLT) has been reported to be effective in pain management and improvement in wound healing through promotion, fortification, and commissioning of cellular cycle to generate productive and substitute cells...
November 23, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29153255/-management-of-hypopigmented-scars-following-burn-injuries
#13
M Schmidt, K Serror, M Chaouat, M Mimoun, D Boccara
OBJECTIVE: Permanent hypopigmentation of burn scars is a common consequence after partial and full thickness burns that heal by secondary intent, and they can cause severe aesthetic issues. The surgical goals for effective treatment of postburn hypopigmentation are to remove scar tissues, and to produce healthy melanocytes, with minimal donor site morbidity. This article reviews the current literature about the different ways to treat hypopigmentation following burn injuries and discusses the indications...
November 15, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29152103/myxinidin2-and-myxinidin3-suppress-inflammatory-responses-through-stat3-and-mapks-to-promote-wound-healing
#14
Hyo Mi Han, Sujin Ko, Min-Ju Cheong, Jeong Kyu Bang, Chang Ho Seo, Tudor Luchian, Yoonkyung Park
Skin wounds are continuously exposed to bacteria and can easily become infected. Infected wounds require antibiotic treatment, and infections caused by drug-resistant bacteria are an important public health problem. Antimicrobial peptides have broad-spectrum antibacterial activity, induce little or no drug resistance and may be suitable for treating skin infections caused by drug-resistant bacteria. We previously reported the design and function of myxinidin and myxinidin analogues. Here we showed that myxinidin2 and myxinidin3 exhibit antimicrobial and anti-biofilm activities against antibiotic-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa in high salt environments and in gelatin...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150821/cd271-mediates-proliferation-and-differentiation-of-epidermal-stem-cells-to-support-cutaneous-burn-wound-healing
#15
Min Zhang, Yongqian Cao, Xiaohong Li, Lizhi Hu, Sahbi Khaled Taieb, Xiaolong Zhu, Jing Zhang, Yongqiang Feng, Ran Zhao, Mingqing Wang, Wenjun Xue, Zhanjie Yang, Yibing Wang
Burn wounds can significantly reduce the quality of life of patients with respect to their physiology and psychology and can even threaten their lives. Many treatments have been proposed, including stem cell therapy but no effective method can as yet cure such damage. Our study highlights the role of Cd271 in epidermal stem cells (eSC) during the healing of burn wounds. The expression of Cd271 increases together with burn wound healing. Injection of Cd271-over-expressing eSC into wounds promotes the healing rate in a mouse burn model...
November 18, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29142785/role-of-cord-blood-and-bone-marrow-mesenchymal-stem-cells-in-recent-deep-burn-a-case-control-prospective-study
#16
Wael Abo-Elkheir, Fawzy Hamza, Ahmed M Elmofty, Atef Emam, Magdy Abdl-Moktader, Sameh Elsherefy, Hala Gabr
RATIONALE: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Thus, they are thought to play a key role in wound healing inducing efficient and physiological skin regeneration...
2017: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29138638/tissue-source-and-cell-expansion-condition-influence-phenotypic-changes-of-adipose-derived-stem-cells
#17
Lauren H Mangum, Shanmugasundaram Natesan, Randolph Stone, Nicole L Wrice, David A Larson, Kyle F Florell, Barbara A Christy, Maryanne C Herzig, Andrew P Cap, Robert J Christy
Stem cells derived from the subcutaneous adipose tissue of debrided burned skin represent an appealing source of adipose-derived stem cells (ASCs) for regenerative medicine. Traditional tissue culture uses fetal bovine serum (FBS), which complicates utilization of ASCs in human medicine. Human platelet lysate (hPL) is one potential xeno-free, alternative supplement for use in ASC culture. In this study, adipogenic and osteogenic differentiation in media supplemented with 10% FBS or 10% hPL was compared in human ASCs derived from abdominoplasty (HAP) or from adipose associated with debrided burned skin (BH)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29138594/prevention-and-treatment-of-acute-and-chronic-radiodermatitis
#18
Sophie Seité, René-Jean Bensadoun, Jean-Michel Mazer
More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point during their treatment. Radiodermatitis either occurs early on in the treatment period or appears months or up to several years later. Acute radiodermatitis is a burn injury that varies in severity according to both treatment and inherent patient factors. Most acute radiodermatitis reactions resolve after several weeks but some reactions persist and can cause complications. Late-onset radiodermatitis is characterized by telangiectasia that forms on atrophic and fragile skin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29137118/modeling-skin-injury-from-hot-spills-on-clothing
#19
Torgrim Log
The present work analyzes scald burns from hot beverages, such as coffee and tea, spilled on the lap, i.e., an incident that may occur in daily life. The Pennes bioheat equation is solved numerically for small spills wetting the clothing, i.e., the fabric prevents the spilled liquid from draining away. Temperatures are analyzed in the wetted fabric and the skin layers and the resulting skin injury is calculated based on the basal layer temperature. Parameters influencing burn severity, such as clothing thickness, liquid temperature, removal of fabric and thermal effects of post scald water cooling are analyzed...
November 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29133853/dispersion-of-tio2-nanoparticles-improves-burn-wound-healing-and-tissue-regeneration-through-specific-interaction-with-blood-serum-proteins
#20
Gulaim A Seisenbaeva, Karin Fromell, Vasiliy V Vinogradov, Aleksey N Terekhov, Andrey V Pakhomov, Bo Nilsson, Kristina Nilsson Ekdahl, Vladimir V Vinogradov, Vadim G Kessler
Burn wounds are one of the most important causes of mortality and especially morbidity around the world. Burn wound healing and skin tissue regeneration remain thus one of the most important challenges facing the mankind. In the present study we have addressed this challenge, applying a solution-stabilized dispersion TiO2 nanoparticles, hypothesizing that their ability to adsorb proteins will render them a strong capacity in inducing body fluid coagulation and create a protective hybrid material coating. The in vitro study of interaction between human blood and titania resulted at enhanced TiO2 concentrations in formation of rather dense gel composite materials and even at lower content revealed specific adsorption pattern initiating the cascade response, promising to facilitate the regrowth of the skin...
November 13, 2017: Scientific Reports
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