keyword
MENU ▼
Read by QxMD icon Read
search

Burn healing

keyword
https://www.readbyqxmd.com/read/28632906/improving-the-histologic-characterization-of-burn-depth
#1
Angela L F Gibson, Daniel D Bennett, Lauren J Taylor
BACKGROUND: Visual assessment of burn wound appearance is the standard of care to determine the depth of thermal injury but often incorrectly predicts wound healing potential. Histologic evaluation of hematoxylin and eosin (H&E) stained burn tissue is prone to subjectivity and is challenging for the novice. Lactate dehydrogenase (LDH) staining may offer a simplified and consistent technique to identify burn tissue viability. METHODS: Thirty tissue samples were obtained from six patients undergoing surgical excision for clinically determined deep partial thickness or full thickness burns...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28619236/the-effect-of-isolated-soy-protein-adjunctive-with-flaxseed-oil-on-markers-of-inflammation-oxidative-stress-acute-phase-proteins-and-wound-healing-of-burn-patients-a-randomized-clinical-trial
#2
Siavash Babajafari, Masoumeh Akhlaghi, Seyed Mohammad Mazloomi, Mehdi Ayaz, Ali Noorafshan, Peyman Jafari, Abdollah Hojhabrimanesh
INTRODUCTION: The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients. METHODS: One hundred eighty-eight patients were assessed for eligibility in this randomized controlled trial. Of these, seventy-three eligible patients (total burn surface area 20-50%) were randomly assigned to 3 isocaloric groups, labeled as control (wheat flour+corn oil (CO)), ISP+FO, and ISP+CO, to receive these nutrients for 3 weeks...
June 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28616231/lymph-node-transfer-for-refractory-infectious-sites-caused-by-trauma
#3
Makoto Mihara, Hisako Hara, Kazuki Kikuchi
OBJECTIVE: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection. CASE AND RESULTS: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. After conservative treatment, we transferred a lymph-node-containing free superficial circumflex iliac artery perforator flap to the region, with minimum debridement...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28614412/differential-effects-of-losartan-and-atorvastatin-in-partial-and-full-thickness-burn-wounds
#4
Johanneke J Akershoek, Katrien M Brouwer, Marcel Vlig, Bouke K H L Boekema, Rob H J Beelen, Esther Middelkoop, Magda M W Ulrich
Healing of burn wounds is often associated with scar formation due to excessive inflammation and delayed wound closure. To date, no effective treatment is available to prevent the fibrotic process. The Renin Angiotensin System (RAS) was shown to be involved in fibrosis in various organs. Statins (e.g. Atorvastatin), Angiotensin receptor antagonists (e.g. Losartan) and the combination of these drugs are able to reduce the local RAS activation, and reduced fibrosis in other organs. We investigated whether inhibition of the RAS could improve healing of burn wounds by treatment with Atorvastatin, Losartan or the combination of both drugs...
2017: PloS One
https://www.readbyqxmd.com/read/28606808/sambulin-a-and-b-non-glycosidic-iridoids-from-sambucus-ebulus-exert-significant-in-vitro-anti-inflammatory-activity-in-lps-induced-raw-264-7-macrophages-via-inhibition-of-mapks-s-phosphorylation
#5
İrem Atay Balkan, Ayca Zeynep İlter Akülke, Yeşim Bağatur, Dilek Telci, Ahmet Ceyhan Gören, Hasan Kırmızıbekmez, Erdem Yesilada
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices prepared are directly applied externally to heal burns, edema, eczema, urticarial and abscess. Two iridoids were recently isolated (sambulin A, sambulin B) from the leaves of S. ebulus. AIM OF THE STUDY: This study aims to investigate the in vitro anti-inflammatory activities of these iridoids on LPS-induced RAW 264...
June 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28605991/-i-in-vivo-i-assessment-of-engineered-skin-cell-delivery-with-multimodal-optical-microscopy
#6
Andrew J Bower, Ziad Mahmassani, Youbo Zhao, Eric J Chaney, Marina Marjanovic, Min Kyung Lee, Benedikt Graf, Michael De Lisio, Hyun Joon Kong, Marni D Boppart, Stephen A Boppart
The healing process is often significantly impaired under conditions of chronic or large area wounds, which are often treated clinically using autologous split-thickness skin grafts. However, in many cases, harvesting of donor tissue presents a serious problem such as in the case of very large area burns. In response to this, engineered biomaterials have emerged that attempt to mimic the natural skin environment or deliver a suitable therapy to assist in the healing process. In this study, a custom-built multimodal optical microscope capable of noninvasive structural and functional imaging is used to investigate both the engineered tissue microenvironment and the <i>in vivo</i> wound healing process...
June 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28602628/overexpression-of-fibulin-5-attenuates-burn-induced-inflammation-via-trpv1-cgrp-pathway
#7
Xiaoqian Hou, Hui Li, Chunhua Zhang, Junling Wang, Xiuli Li, Xin Li
Fibulin-5, a multifunctional extracellular matrix protein, is up-regulated in response to mechanical injury and can promote dermal wound healing. This study aimed to explore the role and mechanism of Fibulin-5 in the pathogenesis of post-burn inflammation in thermally-injured mice. Here, we found that Fibulin-5 was up-regulated in the dorsal root ganglion (DRG) of burn-injured mice. After nociceptive behavioral testing, DRG was isolated and cultured to detect the mechanism of Fibulin-5 in thermal injury models by recombinant adenovirus overexpressing Fibulin-5, RT-qPCR, Western Blot, ELISA, AP20187 (an activator of one kind of kinase phosphorylating the α subunit of eukaryotic initiation factor 2, eIF2α), capsaicin (an agonist of transient receptor potential vanilloid (TRPV)-1), and an anti-CGRP neutralizing antibody...
June 8, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28602593/split-thickness-skin-graft-meshing-ratio-indications-and-common-practices
#8
Stahs Pripotnev, Anthony Papp
BACKGROUND: Split thickness skin grafting is a commonly used technique in burn surgery for resurfacing wounds that are unlikely to heal without scarring. Meshing and expanding skin grafts allow for reconstruction of larger wounds with smaller donor sites. METHODS: A retrospective chart review was performed of 210 patients with burns equal to or greater than 20% total body surface area admitted to Vancouver General Hospital between 1998 and 2014. Charts were reviewed to collect data on patient and burn demographics...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28602591/skin-grafts-from-genetically-modified-%C3%AE-1-3-galactosyltransferase-knockout-miniature-swine-a-functional-equivalent-to-allografts
#9
D A Leonard, C Mallard, A Albritton, R Torabi, M Mastroianni, D H Sachs, J M Kurtz, C L Cetrulo
Burn is associated with a considerable burden of morbidity worldwide. Early excision of burned tissue and skin grafting of the resultant wound has been established as a mainstay of modern burn therapy. However, in large burns, donor sites for autologous skin may be limited. Numerous alternatives, from cadaver skin to synthetic substitutes have been described, each with varying benefits and limitations. We previously proposed the use of genetically modified (alpha-1,3-galactosyl transferase knockout, GalT-KO) porcine skin as a viable skin alternative...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28598760/the-use-of-modern-dressings-in-managing-split-thickness-skin-graft-donor-sites-a-single-centre-randomised-controlled-trial
#10
M Kazanavičius, A Cepas, V Kolaityte, R Simoliuniene, R Rimdeika
OBJECTIVE: To identify the most appropriate, most suitable and most efficient dressing for split-thickness skin graft (STSG) donor sites. Comparing the wound healing rate, pain severity and duration, as well as the dressing change frequency in four randomised patient groups. METHODS: A single-centre non-blinded randomised controlled trial was carried out during 2010-2014. All patients treated for skin defects/lesions (due to burns, trauma or ulcers) using STSG were included in the study...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28594320/silver-containing-foam-dressings-with-safetac-a-review-of-the-scientific-and-clinical-data
#11
Phil Davies, Sara McCarty, Kristina Hamberg
Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag...
June 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28592936/grafting-both-acute-wound-site-and-adjacent-donor-site-with-the-same-graft-an-easy-and-safe-procedure-to-improve-healing-and-minimize-pain-in-elderly-and-bedridden-patients
#12
C Keilani, D Agard, A Duhoux, A Lakhel, O Giraud, M Brachet, P Duhamel, E Bey
In harvesting skin to cover the defect caused by a burn, a second wound is created, the donor site wound. We propose an alternative method to manage the donor site: taking a split-thickness skin graft (STSG) from a donor site adjacent to the burn wound to be treated, and meshing at a 3:1 ratio to cover both sites at once. The main objective of this study is to evaluate the effectiveness of covering both burn wound and adjacent donor site with the same STSG in elderly and bedridden patients. We retrospectively reviewed the medical records of 6 patients over 60 years old or/and bedridden presenting with a small burn wound who underwent STSG of both burn wound and adjacent donor site between April 2016 and November 2016 in the Department of Plastic Surgery and Burn Treatment at Percy Military Hospital (France)...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28592934/new-dressing-combination-for-the-treatment-of-partial-thickness-burn-injuries-in-children
#13
G Józsa, E Tóth, Zs Juhász
Burns are among the most common causes of injury in children. Several wound dressings are available to conservatively treat second-degree burns. Seventy-three children were treated with Aquacel Ag foam and Zn-hyaluronon gel to determine their effectiveness on partial thickness burns. We applied silver nitrate solution on 25% of patients for 24 hrs, then checked burn depth. If the burn was superficial second degree, we applied the dressing under study. All dressings were removed 6-7 days later. In the remaining children we used Aquacel Ag foam dressing with Zn-hyaluronon gel at first intervention...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28592933/prevalence-of-biofilm-producing-aerobic-bacterial-isolates-in-burn-wound-infections-at-a-tertiary-care-hospital-in-northern-india
#14
S Asati, U Chaudhary
Burn wounds frequently get infected due to a break in skin integrity and prolonged hospitalization. Microbial flora originating from the patient's own flora colonize and infect the burn wounds. Bacterial biofilms in particular are postulated as the culprit for the development of non-healing burn wounds by inducing chronic inflammation in these patients. In the present study, 190 wound isolates obtained from patients admitted to the burn ward at the Pt. B.D. Sharma PGIMS, Rohtak, were evaluated for biofilm formation along with Antimicrobial Susceptibility Testing (AST)...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28592926/the-treatment-of-palmar-contact-burns-in-children-a-five-year-review
#15
I Grossova, R Zajicek, R Kubok, M C Smula
Pediatric palmar contact burns are becoming a common trauma, especially in young children. Treatment of this kind of burn is challenging as well as controversial, regarding the choice between split-thickness or full-thickness skin graft to close the defect. The aim of this review was to evaluate the treatment algorithm at our clinic. We conducted a retrospective study including all patients 0 - 5 years of age admitted to our department from 2008 to 2012 with isolated superficial or deep partial-thickness palmar burns...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28591686/the-role-of-topically-applied-l-ascorbic-acid-in-ex-vivo-examination-of-burn-injured-human-skin
#16
Anna Pielesz, Dorota Biniaś, Rafał Bobiński, Ewa Sarna, Jadwiga Paluch, Wioletta Waksmańska
Wound treatment and healing is complex and is comprised of an elaborate set of processes including cellular, spectroscopic and biochemical ones as well as the "reaction" of local tissue to thermal injury. Vitamin C as l-ascorbic acid (LA) prevents injurious effects of oxidants because it reduces reactive oxygen species to stable molecules, it becomes oxidized to the short-lived ascorbyl radical. As a result, antioxidant treatment may contribute to minimizing injury in burn patients. The aim of this study is to assess changes in molecular structure of collagen extracted from human epidermis burn wound scab during incubation of the epidermis in l-ascorbic acid solution...
May 30, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28584222/paederus-dermatitis
#17
REVIEW
Kaliaperumal Karthikeyan, Annapurna Kumar
Paederus dermatitis is an irritant dermatitis caused by pederin, a toxin produced by the rove beetle (Paederus). The disease occurs worldwide, but it is often not recognized as a history of contact with the insect is frequently absent. It is commonly seen in the rainy season. Crushing the insect releases pederin, resulting in the characteristic linear lesions with a burning sensation that heal with hyperpigmentation. Treatment comprises immediate washing of the area to eliminate the toxin and topical application of a topical steroid-antibiotic combination...
July 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28576252/skin-substitutes-and-bioscaffolds-temporary-and-permanent-coverage
#18
REVIEW
Anthony G Haddad, Giorgio Giatsidis, Dennis P Orgill, Eric G Halvorson
Advancements in surgical wound treatment have led to skin substitutes and bioscaffolds as temporary and permanent coverage for burn wounds. Skin substitutes are used to improve wound coverage and restore the functional and aesthetic qualities of skin, and help to prevent wound infection and maintain a moist wound healing environment. Although allografts are preferred when autografts are not possible, high costs and limited availability have led to the use of xenografts and the development of skin substitutes and bioscaffolds...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28576249/pediatric-burn-care-unique-considerations-in-management
#19
REVIEW
Amita R Shah, Lillian F Liao
Severe pediatric burns require a multidisciplinary team approach at a specialized pediatric burn center. Special attention must be paid to estimations of total body surface area, fluid resuscitation and metabolic demands, and adequate analgesia and sedation. Long-term effects involve scar management and psychosocial support to the child and their family. Compassionate comprehensive burn care is accomplished by a multidisciplinary team offering healing in the acute setting and preparing the child and family for long-term treatment and care...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28570443/outcomes-of-geriatric-burns-treated-as-outpatients
#20
Shinsuke Tanizaki
OBJECTIVE: Most literature about geriatric burns has focused on inpatient management; therefore, our study investigated the effects of burn characteristics and preexisting medical comorbidities on treatment outcomes for geriatric burn patients treated as outpatients. METHODS: A retrospective review was conducted for 391 patients over 65 years of age seen in the emergency department of Fukui Prefectural Hospital over a 10-year period. Charts were reviewed for age, sex, burn characteristics, burn mechanisms, preexisting medical comorbidities, and treatment outcomes...
May 31, 2017: Annals of Plastic Surgery
keyword
keyword
106383
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"