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https://www.readbyqxmd.com/read/29453974/genetically-modified-bone-mesenchymal-stem-cells-with-tgf-%C3%AE-3-improve-wound-healing-and-reduce-scar-tissue-formation-in-a-rabbit-model
#1
Mingyong Li, Lin Qiu, Wei Hu, Xiang Deng, Hanfeng Xu, Youhan Cao, Zijian Xiao, Liangyu Peng, Shawn Johnson, Lyundup Alexey, Paul A Kingston, Qing Li, Yuanyuan Zhang
Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β 3 ), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model...
February 14, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29453855/nerve-reinnervation-and-itch-behaviour-in-a-rat-burn-wound-model
#2
Tiam M Saffari, Barthold N Schüttenhelm, Johan W van Neck, Jan C Holstege
In this study, we investigated whether post-burn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as sec/hr) at 24 hours, 2, 4, 8 and 12 weeks post-burn and combined this with immunohistochemistry for protein gene product 9.5 (PGP9.5) to identify all nerve fibers, calcitonin gene related peptide (CGRP) to identify peptidergic fibers, tyrosine hydroxylase (TH) for sympathetic fibers and growth-associated protein 43 (GAP-43) for regrowing fibers...
February 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29442539/platelets-in-wound-healing-and-regenerative-medicine
#3
Julia Etulain
Although platelets are widely recognized as having a critical role in primary hemostasis and thrombosis, increasing experimental and clinical evidence identifies these enucleated cells as relevant modulators of other physiopathological processes including inflammation and tissue regeneration. These phenomena are mediated through the release of growth factors, cytokines, and extracellular matrix modulators that sequentially promote (i) revascularization of damaged tissue through the induction of migration, proliferation, differentiation, and stabilization of endothelial cells in new blood vessels; (ii) restoration of damaged connective tissue through migration, proliferation, and activation of fibroblasts; and (iii) proliferation and differentiation of mesenchymal stem cells into tissue-specific cell types...
February 14, 2018: Platelets
https://www.readbyqxmd.com/read/29440678/development-of-a-bacterial-cellulose-based-hydrogel-cell-carrier-containing-keratinocytes-and-fibroblasts-for-full-thickness-wound-healing
#4
Evelyn Yun Xi Loh, Najwa Mohamad, Mh Busra Fauzi, Min Hwei Ng, Shiow Fern Ng, Mohd Cairul Iqbal Mohd Amin
Bacterial cellulose (BC)/acrylic acid (AA) hydrogel has successfully been investigated as a wound dressing for partial-thickness burn wound. It is also a promising biomaterial cell carrier because it bears some resemblance to the natural soft tissue. This study assessed its ability to deliver human epidermal keratinocytes (EK) and dermal fibroblasts (DF) for the treatment of full-thickness skin lesions. In vitro studies demonstrated that BC/AA hydrogel had excellent cell attachment, maintained cell viability with limited migration, and allowed cell transfer...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438815/new-onset-squamous-cell-carcinoma-in-previous-split-thickness-skin-graft-donor-site
#5
Vincent J Noori, Kanika Trehan, Alisa Savetamal, Damien W Carter
INTRODUCTION: Marjolin' s ulcer, an aggressive ulcerating squamous cell carcinoma, is a well-known phenomenon that occurs in chronically inflamed or scarred tissue; however, squamous cell carcinoma arising in the acute setting after tissue trauma - specifically autograft donor harvest sites for burns - is a rare, but notable event. METHODS: This case series describes three instances of squamous cell carcinoma diagnosed in split-thickness skin graft donor sites in the immediate post-operative period...
February 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29438425/treatment-with-silver-nitrate-versus-topical-steroid-treatment-for-umbilical-granuloma-a-non-inferiority-randomized-control-trial
#6
Chikako Ogawa, Yoshiaki Sato, Chiyo Suzuki, Azusa Mano, Atsushi Tashiro, Takafumi Niwa, Sayako Hamazaki, Yoshihiro Tanahashi, Midori Suzumura, Satoshi Hayano, Masahiro Hayakawa, Takeshi Tsuji, Shin Hoshino, Yuichiro Sugiyama, Hiroyuki Kidokoro, Jun-Ichi Kawada, Hideki Muramatsu, Akihiro Hirakawa, Masahiko Ando, Jun Natsume, Seiji Kojima
OBJECTIVE: The aim of this prospective multicenter randomized controlled trial was to compare the efficacy of silver nitrate cauterization against that of topical steroid ointment in the treatment of neonatal umbilical granuloma. METHODS: An open-label, non-inferiority randomized controlled trial was conducted from January 2013 to January 2016. The primary endpoint for the silver nitrate cauterization and topical steroid ointment groups was the healing rate after 2 weeks of treatment, applying a non-inferiority margin of 10%...
2018: PloS One
https://www.readbyqxmd.com/read/29438144/long-term-scar-quality-after-treatment-of-standardized-partial-thickness-skin-graft-donor-sites
#7
Alexandra Schulz, Irene Rothermund, Rolf Lefering, Paul Christian Fuchs, Jennifer Schiefer
BACKGROUND: The long-term aesthetic appearance of scars is of great importance to patients. Biobrane (Smith and Nephew, Fort Worth, Texas), a biosynthetic skin dressing, is a successfully established dressing for the treatment of superficial wounds. A new silk barrier dressing (Dressilk; Prevor, Moulin de Verville, France) has also shown good results in wound healing. This study evaluated the long-term scar quality of superficial wounds treated with these dressings. METHODS: From February 2012 to May 2013, 11 patients with burns in need of skin grafting received donor site treatment...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29430689/dystrophic-calcinosis-cutis-within-burns-successfully-treated-with-excision-and-secondary-intention-wound-healing
#8
K A Lockwood, T Oliphant
No abstract text is available yet for this article.
February 12, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29425875/burn-wound-healing-potential-of-a-polysaccharide-from-sanguisorba-officinalis-l-in-mice
#9
Hongfang Zhang, Junjie Chen, Ying Cen
Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200 mg/kg) significantly stimulated wound contraction and reduced epithelialization time as compared to control group, which might be mediated by promoting collagen synthesis as evidenced by an increase of hydroxyproline content...
February 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29424945/in-vitro-and-in-vivo-investigation-of-a-novel-amniotic-based-chitosan-dressing-for-wound-healing
#10
Maryam Momeni, Mohammad Zarehaghighi, Mirhamed Hajimiri, Ghasemali Khorasani, Rassoul Dinarvand, Abdolhossein Nekookar, Niloofar Sodeifi, Pardis Khosravani, Niloofar Shayanasl, Marzieh Ebrahimi
It is more than a decade that amniotic membrane has been used as a wound dressing because of its anti-inflammatory, anti-microbial, anti-fibrotic, anti-scaring properties, as well as its pain relieving and epithelialization promoting features. However, amniotic membrane had limited applications because it needs to suture in surgery, is highly fragile, firmly adhere to the wound and may cause bleeding and pain when changing the bandage. This study investigated the possibility of development of a novel amniotic-based chitosan gel dressing as a potential wound repair substrate with marked efficacy...
February 9, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29423009/negatively-charged-aerosol-improves-burn-wound-healing-by-promoting-enos-dependent-angiogenesis
#11
Jingling Zhao, Fei Zhou, Lei Chen, Bin Shu, Qiyi Zhai, Jun Wu, Xusheng Liu, Shaohai Qi, Yingbin Xu
Aerosols exist in the form of liquid or solid particles that stably suspending in air. Our previous studies have found that aerosol can accelerate chronic wound healing. However, the biological effects of aerosol in burn wound healing and the underlying molecular mechanism remain unclear. This study aimed to investigate the effects of aerosol on the healing of deep partial-thickness burn wounds and its regulatory mechanisms. By employing a self-controlled model of rats, we demonstrated that aerosol treatment not only increased the healing rate, but also improved the healing quality of deep partial-thickness burn wounds...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29421548/bacteria-responsive-intelligent-wound-dressing-simultaneous-in-situ-detection-and-inhibition-of-bacterial-infection-for-accelerated-wound-healing
#12
Jin Zhou, Danyu Yao, Zhiyong Qian, Sen Hou, Linhao Li, A Tobias A Jenkins, Yubo Fan
The evolved resistance of antibiotics exhibited by some dreaded clinical pathogens and formation of biofilms has caused life-threatening problems for patients with burns and other wounds. Here, in order to avoid antibiotic overuse, and thus decreasing the occurrence of antimicrobial-resistant bacteria, a theranostic wound dressing, composed of biocompatible UV-photocrosslinkable methacrylated gelatin (GelMA) encapsulating both antimicrobial and fluorescent vesicles, has been developed. The system can respond to the microbiological environment of the wound via a simple color change and antimicrobials release only when require and this is in essence passive as they do not respond to their local environments and benign bacteria, and only operates when pathogenic bacteria exist...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29419365/meek-micrografting-history-indications-technique-physiology-and-experience-a-review-article
#13
Eduardo Camacho Quintero, Jesús Francisco Escrivá Machado, Roger Andres Damian Robles
AIMS: Traumatic loss of skin, particularly in major burns, requires skin grafting to repair the tissue. For a large burn, where donor sites are limited, the skin graft may need to be expanded. In addition, rapid wound closure is a large factor in successful recovery and is usually achieved by debridement and skin grafting. Micrografting was introduced by Meek and involved dividing the skin into small pieces, allowing for up to a tenfold skin expansion. METHODS: We conducted a review of the literature, searched via Medline, Pubmed and Embase (from 1958 to June 2017), searching to identify studies and reports of micrografting...
February 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29416798/runx2-promotes-epithelial-differentiation-of-adscs-and-burn-wound-healing-via-targeting-e-cadherin
#14
Qiang Li, Han Zhao, Sizhan Xia, Hanxiao Wei, Feifei Chen, Peisheng Jin
Epithelial differentiation of adipose-derived stem cells (ADSCs) is mediated by sophisticated interactions of various molecular functions and biological processes, including transcriptional regulation. Runt-related transcription factor 2 (RUNX2) increases osteoblast and adipocyte differentiation of ADSCs. However, the role of RUNX2 in epithelial differentiation of ADSCs is unknown. We first showed that ADSCs possess the potential to differentiate into epithelial lineage. Then, we employed the effect of RUNX2 on epithelial differentiation of ADSCs...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413607/development-of-nanoparticles-from-natural-lipids-for-topical-delivery-of-thymol-investigation-of-its-anti-inflammatory-properties
#15
Thais P Pivetta, Sandra Simões, Margarete M Araújo, Tânia Carvalho, Caroline Arruda, Priscyla D Marcato
Wound healing involves the integration of biological and molecular events and, in case of chronic wounds, the use of drugs can be associated to side effects. Therefore, there is a search for alternatives therapeutics that encompass minimal toxicity. The use of natural compounds is an attractive approach for treating inflammatory disorders, wounds and burns. In this context, thymol has antimicrobial, antioxidant and antiseptic properties and is a promising compound in wound healing and inflammation management...
January 31, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29409904/early-assessment-of-burn-depth-with-far-infrared-time-lapse-thermography
#16
Jon D Simmons, Steven A Kahn, Adrienne L Vickers, Edward S Crockett, Jonathon D Whitehead, Amy K Krecker, Yann-Leei Lee, Adam N Miller, Scott B Patterson, William O Richards, Wiltz W Wagner
BACKGROUND: Diagnosing the extremes of superficial burns and of full-thickness burns is straightforward. It is in the middle ground of partial thickness burns where the diagnostic difficulties emerge; it can take up to 3-5 days for signs of healing to appear. We hypothesize that cooling partial thickness burns and tracking the rate of rewarming will immediately reflect the condition of the burn: shallow partial-thickness burns that retain cell health and blood flow will rewarm rapidly, whereas deeper burns with damaged microvessels will rewarm slowly...
January 30, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29409208/increased-rates-of-delayed-union-after-percutaneous-akin-osteotomy
#17
Mario Herrera-Perez, Mariano De Prado-Serrano, María José Gutiérrez-Morales, Juan Boluda-Mengod, José Luis Pais-Brito
BACKGROUND: Akin osteotomy is a well-known surgical procedure in forefoot surgery. When performing percutaneously, we have found a lot of delayed unions on follow up X-rays. The objective of this study was to assess the incidence of delayed union when performing a percutaneous Akin osteotomy. METHODS: We report a series of 26 cases who underwent minimally invasive (percutaneous) Akin osteotomy. The mean follow-up duration was 17.6 (range 12 to 24) months. We analys-24) months...
April 24, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29408210/chitosan-hydrogel-in-combination-with-marine-peptides-from-tilapia-for-burning-healing
#18
Qian-Qian Ouyang, Zhang Hu, Zhen-Peng Lin, Yi-Feng Deng, Wei-Yan Quan, Si-Dong Li, Peng-Zhi Hong, Pu-Wang Li, Cheng-Peng Li, Yu Chen, Ting-Ting Yan, Qing-Kun Zhong
The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material in this study (coded as CSMP) showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29406294/evidence-corner-taking-itch-seriously
#19
Laura T Bolton
Dear Readers, Itching (pruritus) of a wound, scar, or dermatologic disorder can negatively impact a patient's quality of life, resulting in injurious scratching1 or impeded rehabilitation.2 Like pain, itch can cause the su erer to lose sleep and appetite or even consider suicide.3,4 Clinical measures of pruritus have proved reliable and valid in individuals with burn wounds, dermatologic conditions, or urticaria5-7 or resulting scars,2 allowing studies to clarify its impact on human experience and compare the e ects of interventions to reduce itching...
January 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29405795/oral-mucosa-grafting-in-periorbital-reconstruction
#20
Andre Grixti, Raman Malhotra
To provide an extensive literature review on the clinical indications of oral mucosa grafts (OMG) and minor salivary gland grafts (MSGG) in periorbital reconstruction together with safe practice graft harvesting techniques to minimize donor-site morbidity. A literature review was performed by searching the databases of PUBMED, EMBASE, and COCHRANE library using the keywords: minor salivary glands; oral mucosal graft; orbit; and eye. The bibliographies of the pertinent articles were examined for additional papers...
February 6, 2018: Orbit
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