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https://www.readbyqxmd.com/read/29049055/oxidized-regenerated-cellulose-collagen-dressings-review-of-evidence-and-recommendations
#1
Stephanie Wu, Andrew J Applewhite, Jeffrey Niezgoda, Robert Snyder, Jayesh Shah, Breda Cullen, Gregory Schultz, Janis Harrison, Rosemary Hill, Melania Howell, Marcus Speyrer, Howard Utra, Jean de Leon, Wayne Lee, Terry Treadwell
OBJECTIVE: Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds. DESIGN: A multidisciplinary panel meeting was convened to discuss the use of ORC/collagen dressings in wound care and provide practice recommendations...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29034271/effect-of-propolis-extract-in-combination-with-eugenol-free-dressing-coe-paktm-on-pain-and-wound-healing-after-crown-lengthening-a-randomized-clinical-trial
#2
Mitra Askari, Anna Saffarpour, Jalal Purhashemi, Atena Beyki
STATEMENT OF THE PROBLEM: Researchers have long been in search of products to enhance healing and patient comfort postoperatively. PURPOSE: This study aimed to assess the efficacy of propolis extract in combination with Coe-Pak(TM) dressing for pain relief and wound healing after crown lengthening surgery. MATERIALS AND METHOD: This randomized clinical trial was performed on 36 patients who were randomly divided into two groups of Coe-Pak(TM) dressing with (trial group) and without (control group) propolis extract...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29032979/a-treatment-algorithm-for-the-management-of-intraoral-burns-a-narrative-review
#3
REVIEW
Steve Kang, Kenneth Kufta, Thomas P Sollecito, Neeraj Panchal
Oral mucosa follows a distinctly different trajectory of wound healing than skin. Although there are contemporary guidelines regarding treatment of burns to the skin, there is no standard of care specific to intraoral burns. This narrative review proposes an evidence-based treatment algorithm for the management of intraoral burns. Data was collated through a comprehensive review of the literature and only included studies that have reported particular success with favorable short- and long-term prognoses. In order to critically appraise the strength of the treatment recommendations, the GRADE criteria was applied to each arm of the algorithm...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032975/comparison-of-non-surgical-methods-for-the-treatment-of-deep-partial-thickness-skin-burns-of-the-hand
#4
Ernest Zacharevskij, Gytis Baranauskas, Karolis Varkalys, Rytis Rimdeika, Darius Kubilius
This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. The trial enrolled 87 patients with hand burn wounds in the section of 260-600PU. Hand burn patients were divided into the following four groups: treated with hydrocolloid dressings; treated with mechanical debridement of monofilament polyester fibers pad and then applying silver sulfadiazine; treated with gauze dressings containing enzymatic collagenase preparation...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032968/early-intervention-by-captopril-does-not-improve-wound-healing-of-partial-thickness-burn-wounds-in-a-rat-model
#5
Johanneke J J Akershoek, Katrien M Brouwer, Marcel Vlig, Bouke K H L Boekema, Rob H J Beelen, Esther Middelkoop, Magda M W Ulrich
The Renin Angiotensin System is involved in fibrotic pathologies in various organs such as heart, kidney and liver. Inhibition of this system by angiotensin converting enzyme antagonists, such as Captopril, has been shown beneficial effects on these pathologies. Captopril reduced the inflammatory reaction but also directly influenced the fibrotic process. Prolonged and excessive inflammatory response is a major cause of hypertrophic scar formation in burns. We therefore evaluated the effect of Captopril on the healing of partial thickness burn wounds in a rat model...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031640/the-application-of-mesenchymal-stem-cells-to-treat-thermal-and-radiation-burns
#6
Kathleen Rodgers, Sachin S Jadhav
Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns...
October 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29025669/preparation-and-evaluation-of-squid-ink-polysaccharide-chitosan-as-a-wound-healing-sponge
#7
Na Huang, Jiali Lin, Sidong Li, Yifeng Deng, Songzhi Kong, Pengzhi Hong, Ping Yang, Mingneng Liao, Zhang Hu
A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS)...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29021723/bacterial-infections-in-burn-wound-patients-at-a-tertiary-teaching-hospital-in-accra-ghana
#8
O A Forson, E Ayanka, M Olu-Taiwo, P J Pappoe-Ashong, P J Ayeh-Kumi
Intact human skin surface is essential for protection against infection, preservation of body fluid homeostasis and thermoregulation. Burn injury compromises the skin barrier and enables bacterial infection, hence delaying burn wound healing. This study aimed to determine the microbial profile of burn wounds, and resistance patterns of microbes with respect to the source of the injured patient's wound. Fifty wound swab samples were collected from fifty burn patients at the Korle-Bu Teaching Hospital, Accra (KBTH)...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29018761/using-stem-cell-biology-to-study-and-treat-ophthalmologic-and-oculoplastic-diseases
#9
REVIEW
Albert Y Wu, Michael G Daniel
With the rapid growth of the stem cell biology field, the prospect of regenerative medicine across multiple tissue types comes closer to reality. Several groundbreaking steps paved the way for applying stem cell biology to the several subfields within ophthalmology and oculoplastic surgery. These steps include the use of stem cell transplants as well as studies of various ophthalmologic pathologies at the molecular level. The necessity of stem cell transplant is readily apparent, having already been used for several studies such as artificial lacrimal gland design and eyelid reconstruction...
April 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29017952/a-biocompatible-sodium-alginate-povidone-iodine-film-enhances-wound-healing
#10
Maria Summa, Debora Russo, Ilaria Penna, Natasha Margaroli, Ilker S Bayer, Tiziano Bandiera, Athanassia Athanassiou, Rosalia Bertorelli
In the last few years, there has been an increasing tendency to use natural polymers for the fabrication of dressings for wound and burn management. Among them, alginate, a polysaccharide extracted primarily from marine algae, exhibits attractive properties being non-toxic, hydrophilic and biodegradable. The aim of this study was to characterize the in vitro biocompatibility and the efficacy of a composite polymeric material based on sodium alginate (NaAlg) and povidone iodine (PVPI) complex in a mouse model of wound healing...
October 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29017529/short-review-on-human-umbilical-cord-lining-epithelial-cells-and-their-potential-clinical-applications
#11
REVIEW
Razwa Saleh, Hasan Mahmud Reza
BACKGROUND: The human umbilical cord has been studied extensively in the past two decades. It is free of ethical dilemmas, non-tumorigenic, and less immunogenic and thus provides a significant advantage over other stem cell sources. The cord lining yields both mesenchymal and epithelial stem cells. The mesenchymal cells have been appraised at length by many researchers, which led to the current review focusing on the cord lining epithelial cells (CLECs). These cells have high proliferative capacity and their superior harvest and multiplication, using the revolutionary CellOptima(TM) technology, makes them better candidates in comparison to contemporary adult stem cells...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28992774/treatment-of-a-burn-animal-model-with-functionalized-tridimensional-electrospun-biomaterials
#12
Daniela Steffens, Monica Beatriz Mathor, Paula Rigon da Luz Soster, Gustavo Vergani, Dayane Piffer Luco, Patricia Pranke
Laminin-functionalized poly-d,l-lactic acid scaffolds were produced. Following this, mesenchymal stem cells and keratinocytes were seeded on biomaterials for the in vivo experiments, where the biomaterials with or without cells were implanted. The analysis is comprised of the visual aspect and mean size of the lesion plus the histology and gene expression. The results showed that the cells occupied all the structure of the scaffolds in all the groups. After nine days of in vivo experiments, the defect size did not show statistical difference among the groups, although the groups with the poly-d,l-lactic acid/Lam biomaterial had the lowest lesion size and presented the best visual aspect of the wound...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28990101/exogenous-peripheral-blood-mononuclear-cells-affect-the-healing-process-of-deep%C3%A2-degree-burns
#13
Guanying Yu, Yaonan Li, Lan Ye, Xinglei Wang, Jixun Zhang, Zhengxue Dong, Duyin Jiang
The regenerative repair of deep‑degree (second degree) burned skin remains a notable challenge in the treatment of burn injury, despite improvements being made with regards to treatment modality and the emergence of novel therapies. Fetal skin constitutes an attractive target for investigating scarless healing of burned skin. To investigate the inflammatory response during scarless healing of burned fetal skin, the present study developed a nude mouse model, which was implanted with normal human fetal skin and burned fetal skin...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987941/study-of-the-non-clinical-healing-activities-of-the-extract-and-gel-of-portulaca-pilosa-l-in-skin-wounds-in-wistar-rats-a-preliminary-study
#14
Albenise Santana Alves Barros, Helison Oliveira Carvalho, Igor Victor Ferreira Dos Santos, Talisson Taglialegna, Tafnis Ingret Dos Santos Sampaio, Jonatas Lobato Duarte, Caio Pinho Fernandes, José Carlos Tavares Carvalho
INTRODUCTION: Portulaca pilosa L., belonging to the family Portulacaceae, is a common herbaceous plant in the Americas and in the Amazon, is popularly known as love-grown and is traditionally used as an aid in the treatment of burns, buds, insect bites and wound healing. This study aims to evaluate the non-clinical topical healing activity of the P. pilosa gel (GPP) and the propyleneglycol extract of P. pilosa (EPP) in Wistar rats. METHODS: For the healing activity, wistar rats were divided into the following groups: negative control (GVE - vehicle, 150mg/kg), positive control (Fibrinase(®)- FIB, 100U/kg), Portulaca pilosa gel 10%, (GPP, 150mg/kg), and propylenglycollic extract of Portulaca pilosa (EPP, 150 mg/kg), which were submitted to a surgical procedure to obtain the wounds, and were treated topically for 7days...
October 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28969578/regenerative-medicine-applications-in-wound-care
#15
Mohammad Ali Nilforoushzadeh, Mahsa Mollapour Sisakht, Alexander Marcus Seifalian, Mohammad Amir Amirkhani, Hamid Reza Banafsheh, Javad Verdi, Farzaneh Sharifzad, Ehsan Taghiabadi
BACKGROUND: During the last two decades, a number of studies have been published on different aspects of regenerative medicine in the field of dermatology. OBJECTIVE: The following article aims at integrating all available information about regenerative dermatology, from the past to the present. In addition, we focused on most well-known application of regenerative medicine in dermatology field, wound healing, especially for burns and non-healing wounds based on available skin replacement in market...
September 29, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28962758/alginate-coated-chitosan-nanogel-for-the-controlled-topical-delivery-of-silver-sulfadiazine
#16
Gina S El-Feky, Sally T El-Banna, G S El-Bahy, E M Abdelrazek, Mustafa Kamal
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. The aim of the present study is to formulate and evaluate different silver sulfadiazine loaded nanogel formulations. A factorial design experiment was used for the identification of critical process parameters and for the optimization of the respective process conditions. The prepared drug loaded nanogels were characterized for their particle size, zeta potential, entrapment efficiency and swelling index in order to demonstrate their physicochemical properties, in addition, FTIR, TEM, SEM and in vitro release were used for characterization...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28957834/use-of-self-retained-cryopreserved-amniotic-membrane-in-the-treatment-of-acute-chemical-ocular-burn
#17
Adam T Shupe, Anny M S Cheng
SIGNIFICANCE: Ocular chemical injury is a medical emergency in which immediate treatment is critical to prevent visual morbidity. We report a severe ocular burn case that illustrates in-office management to promote rapid re-epithelialization and reduce inflammation to restore ocular surface integrity. PURPOSE: To report a case of severe acid burn that was managed successfully with self-retained cryopreserved amniotic membrane (AM). METHODS: A 43-year-old man presented with complaints of pain, light sensitivity, and blurred vision in both eyes 1 day after ocular exposure to acid...
September 27, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28946718/effects-of-topical-tamoxifen-on-wound-healing-of-burned-skin-in-rats
#18
Shaban Mehrvarz, Ali Ebrahimi, Hedayat Sahraei, Mohammad Hasan Bagheri, Sima Fazili, Shahram Manoochehry, Hamid Reza Rasouli
BACKGROUND: This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue. METHODS: Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals' back, measuring 2×2×2 cm. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks...
September 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28944889/beneficial-effects-of-extracts-from-lucilia%C3%A2-sericata-maggots-on-burn-wounds-in-rats
#19
Haixu Bian, Qiaoli Yang, Tao Ma, Wei Li, Jialin Duan, Guo Wei, Xiaoxiao Wu, Fei Mu, Rui Lin, Aidong Wen, Miaomiao Xi
Lucilia sericata maggots have beneficial properties; however, their protective effects on burn wounds have yet to be fully elucidated. In the present study, a deep second‑degree burn rat model was used to investigate the burn wound healing properties of aqueous extract of maggots (MAE). The anti‑inflammatory, antioxidative and antibacterial activities were examined. In addition, the protein expression levels of Akt, vascular endothelial growth factor A (VEGFA) and nuclear factor‑κB (NF‑κB) were detected by western blotting...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943993/effectiveness-of-a-glycylcycline-antibiotic-for-reducing-the-pathogenicity-of-superantigen-producing-methicillin-resistant-staphylococcus-aureus-in-burn-wounds
#20
Lauren B Nosanov, Daniel Y Jo, Pranay R Randad, Lauren T Moffatt, Bonnie C Carney, Rachel T Ortiz, Jeffrey W Shupp
Objective: Burn-injured patients are highly susceptible to infectious complications, which are often associated with increased morbidity and mortality. Rates of antibiotic resistance have increased, and resistant species such as methicillin-resistant Staphylococcus aureus provide additional challenges in the form of virulence factors. Proteins can disrupt local healing, leading to systemic immune disruption. To optimize outcomes, treatments that reduce pathogenicity must be identified. This study aims to compare a glycylcycline antibiotic-tigecycline-with clindamycin for effectiveness in treating superantigenic methicillin-resistant Staphylococcus aureus in burn wounds...
2017: Eplasty
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