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Fibrin monomer complexes and D- dimer

Shu Zhu, Jason Chen, Scott L Diamond
OBJECTIVE: We investigated the coregulation of thrombin and fibrin as blood flows over a procoagulant surface. APPROACH AND RESULTS: Using microfluidic perfusion of factor XIIa-inhibited human whole blood (200 s- 1 wall shear rate) over a 250-μ long patch of collagen/TF (tissue factor; ≈1 molecule per μm2 ) and immunoassays of the effluent for F1.2 (prothrombin fragment 1.2), TAT (thrombin-antithrombin complex), and D-dimer (post-end point plasmin digest), we sought to establish the transient mass balance for clotting under venous flow...
May 3, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Bérangère S Joly, Bénédicte Sudrié-Arnaud, Virginie Barbay, Jeanne-Yvonne Borg, Véronique Le Cam Duchez
Pregnancy is a well-established risk factor for venous thromboembolism and is associated with a state of hypercoagulability. The use of sensitive and specific biological markers to predict risk factors for thrombosis is essential during pregnancy. Our objective was to investigate the usefulness of thrombin generation test (TGT) as a marker to predict the risk of thrombosis in high risk venous thrombosis (HRVT) pregnancies compared to normal pregnancies. This retrospective study enrolled 134 women with HRVT pregnancies, 78 of whom had monozygotic, spontaneous and untreated pregnancies and formed the study group...
January 2018: Journal of Thrombosis and Thrombolysis
Noémi Klára Tóth, Zoltán Csanádi, Orsolya Hajas, Alexandra Kiss, Edina Nagy-Baló, Kitti Bernadett Kovács, Ferenc Sarkady, László Muszbek, Zsuzsanna Bereczky, László Csiba, Zsuzsa Bagoly
AIMS: To identify intracardiac hemostasis or fibrinolysis abnormalities, which are associated with atrial fibrillation (AF) and increase the risk of thromboembolism. PATIENTS AND METHODS: Patient group consisted of 24 patients with AF and control group included 14 individuals with other supraventricular tachycardia undergoing transcatheter radiofrequency ablation. Blood samples were drawn from the femoral vein (FV), left atrium (LA), and left atrial appendage (LAA) before the ablation procedure...
2017: BioMed Research International
Masatoshi Kochi, Manabu Shimomura, Takao Hinoi, Hiroyuki Egi, Kazuaki Tanabe, Yasuyo Ishizaki, Tomohiro Adachi, Hirotaka Tashiro, Hideki Ohdan
AIM: To examine the role of soluble fibrin monomer complex (SFMC) in the prediction of hypercoagulable state after gastroenterological surgery. METHODS: We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related markers...
March 28, 2017: World Journal of Gastroenterology: WJG
Kenichi Hata, Takahiro Kimura, Shunsuke Tsuzuki, Gen Ishii, Masahito Kido, Toshihiro Yamamoto, Hiroshi Sasaki, Jun Miki, Hiroki Yamada, Akira Furuta, Kenta Miki, Shin Egawa
OBJECTIVES: To prospectively evaluate the safety of postoperative fondaparinux in comparison with low molecular weight heparin in patients undergoing uro-oncological surgery. METHODS: The present study was a prospective, single-blind, non-inferiority randomized trial. A total of 359 patients undergoing surgery for urological malignancy were enrolled from January 2011 to December 2012. A total of 298 of these patients (fondaparinux group, 152; low molecular weight heparin group, 146) were evaluable for the intention-to-treat-analysis...
November 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Hiroshi Kondo, Itsuo Nakagawa, Shozo Hidaka, Yoshinori Okada, Yoshikazu Erabi, Yoshie Kuwahara, Atsushi Morio
BACKGROUND: Some biomarkers are helpful for AD diagnosis. Although many studies on efficacy of D-dimer have been reported, there are few reports about SFMC. Therefore we conducted a retrospective comparative study of efficacy of SFMC and D-dimer for diagnosis of AD. METHODS: Nineteen patients diagnosed as AD in the emergency visit were examined. Patients with cardiopulmonary arrest on arrival were excluded. These patients were classified into three patterns as follows, Stanford A or B, terms of arriving at hospital, and closing type or patent type...
May 2016: Masui. the Japanese Journal of Anesthesiology
Karin B Grossman, Roopen Arya, Alberto B Peixoto, Ranjit Akolekar, Ismini Staboulidou, Kypros H Nicolaides
BACKGROUND: D-dimers have a high negative predictive value for excluding venous thromboembolism outside of pregnancy but the use in pregnancy remains controversial. A higher cut-off value has been proposed in pregnancy due to a continuous increase across gestation. Fibrin monomer complexes have been considered as an alternative diagnostic tool for exclusion of venous thromboembolism in pregnancy due to their different behavior. OBJECTIVE: We sought to establish normal values of fibrin monomer complexes and D-dimer as a diagnostic tool for the exclusion of venous thromboembolism in pregnancy and examine the effect of maternal and obstetric factors on these markers...
October 2016: American Journal of Obstetrics and Gynecology
Genya Mitani, Tomonori Takagaki, Kosuke Hamahashi, Kenji Serigano, Yutaka Nakamura, Masato Sato, Joji Mochida
BACKGROUND: Prevention and early detection of venous thromboembolism (VTE) is important after arthroplasty of the lower limb. The purpose of this study was to investigate the associations between VTE and hemostatic markers after minimally invasive total knee arthroplasty (MIS-TKA). METHODS: We performed a retrospective study of 50 patients (55 knees) who underwent primary unilateral MIS-TKA with periodic determination of D-dimer and soluble fibrin monomer complex (SFMC) concentrations and with ultrasonography...
2015: Journal of Orthopaedic Surgery and Research
N Yu Shimohina, M M Petrova, A A Savchenko, M S Piliugina
OBJECTIVE: To explore the dynamics of hemostasis in patients with acute coronary syndrome (ACS) in the combination with anxiety and depressive disorders (ADD) during therapy with valdoxan (agomelatine). MATERIAL AND METHODS: We examined 196 male and female patients (mean age 64.2 ± 0.8 years) in the first 24 hours of ACS. The patients were divided into three groups: patients with ACS without ADD (n=88), patients with ACS and ADD without valdoxan therapy (n=58) and patients with ACS and ADD treated with valdoxan (n=50)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Masashi Izumi, Masahiko Ikeuchi, Koji Aso, Natsuki Sugimura, Yuko Kamimoto, Tetsuya Mitani, Tadashi Ueta, Takayuki Sato, Masataka Yokoyama, Tetsuro Sugiura, Toshikazu Tani
PURPOSE: It has been known for years that deep vein thrombi (DVT) start to develop during total joint arthroplasty. Previously, we reported effective prevention of venous stasis by transcutaneous electrical nerve stimulation (TENS). It is hypothesized that TENS might be a thromboprophylactic tool for the limb undergoing surgery. The purpose of this study is to clarify the clinical efficacy and safety of TENS in patients during total knee arthroplasty (TKA). METHODS: Ninety patients undergoing primary TKA were involved and randomly allocated to the TENS or control group...
November 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
N V Bedilo, N A Vorob'eva, N V Ismaĭlova, N A Veshchagina, I Ia Nasonov, Iu Iu Malugin
The article deals with a study of hemostasis (D-dimer soluble fibrin-monomer complex, time fibrin self-assemblance, antitrombin III, fibrinogen), endothelial dysfunction (f. Willebrand and activity of plasminogen activators inhibitor type 1) and CRP in 61 patients with CAP in the day of admission and before discharge from hospital 17 patients had a severe pneumonia, 6 people died. The levels of all markers (except AT-3) were increased on admission and were reduced before discharge, but within the normal range to include only FW, CRP and time fibrin self-assemblance...
January 2014: Anesteziologiia i Reanimatologiia
Roland Couturier, Marina Rubatti, Carmen Credico, Virginie Louvain-Quintard, Vregina Anerkian, Sylvie Doubine, Marc Vasse, Stanislas Grassin-Delyle
Tranexamic acid is given continuously or discontinuously as an anti-fibrinolytic therapy during cardiac surgery, but the effects on fibrinolysis parameters remain poorly investigated. We sought to assess the effects of continuous and discontinuous tranexamic acid on fibrinolysis parameters in children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Children requiring cardiac surgery or repeat surgery by sternotomy with CPB for congenital heart disease were randomized to receive either continuous or discontinuous tranexamic acid...
April 2014: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Makoto Kawamura, Naoko Fukuda, Ayako Suzuki, Yusuke Kobayashi, Miho Matsuda, Rieko Kanda, Hisami Kiseki, Yutaka Tsukahara, Naohiko Hashimura
AIM: We measured fibrin monomer complex (FMC) levels in all subjects who gave birth at our hospital and evaluated the feasibility of using FMC for screening for venous thromboembolism (VTE) in patients during late pregnancy and the post-partum period. METHODS: From August 2010 to January 2012, all women who gave birth at our hospital were included. FMC and D-dimer levels were determined during the late pregnancy and post-partum periods. Compression ultrasonography of the lower extremities was performed in women with high FMC values...
March 2014: Journal of Obstetrics and Gynaecology Research
Jian-Rong Guo, Xiao-Ju Jin, Jun Yu, Feng Xu, Yi-Wei Zhang, Hua-Chun Shen, Yi Shao
BACKGROUND: Acute normovolemic hemodilution (ANH) has been widely used to prevent the massive blood loss during hepatic carcinoma. The influences of ANH on coagulation function are still controversy, especially in elderly patients. The study observed ANH effects on coagulation function and fibrinolysis in elderly patients undergoing the disease. MATERIALS AND METHODS: Thirty elderly patients (aged 60-70 yr) with liver cancer (ASA I or II) taken hepatic carcinectomy from February 2007 to February 2008 were randomly divided into ANH group (n=15) and control group (n=15)...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
D S Kuzichkin, A A Markin, B V Morukov, O A Zhuravleva, I V Zabolotskaya, L V Vostrikova
In an experiment with 7-d dry immersion for testing the mechanic foot and electrical muscle stimulation procedures of compensating the support load deficiency the following biochemical parameters were studied: activated partial thromboplastin time, prothrombin time, prothrombin index, international normalized ratio, thrombin time (TT), fibrinogen, soluble fibrin-monomer complexes, D-dimer (DD), plasminogen (PG); antithrombin III activity (ATIII), protein C (PC) and alpha2-antiplasmin (AP). Control subjects (immersed w/o stimulation) did not exhibit significant shifts in the hemostasis system: however, they decreased ATIII, PC and PG in the post-experimental period...
May 2013: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
Berangere Joly, Virginie Barbay, Jeanne-Yvonne Borg, Veronique Le Cam-Duchez
INTRODUCTION: Pregnancy is a well-established risk factor for venous thromboembolism, and is associated with a state of hypercoagulability or parameters of thrombin generation. Currently, there is a lack of consensual data on thrombin generation during pregnancy. This study aimed to find a sensitive and specific biological marker of coagulation activation and to identify parameters of thrombin generation. PATIENTS AND METHODS: The population included 101 women with uncomplicated pregnancies...
September 2013: Thrombosis Research
Daijiro Takahashi, Yukihiro Takahashi, Miyu Matsui, Shunsuke Araki, Kazuyasu Kubo, Hiroshi Sato, Akira Shirahata
BACKGROUND: Soluble fibrin monomer complex (SFMC) and fibrin monomer (FM) are well known as markers for hypercoagulability, but such measurements have not been investigated in detail for the neonate. To identify the presence of a hypercoagulable state in sick newborns, the behavior of SFMC with special reference to those of other coagulation tests, and the relationships with other parameters of blood coagulation as well as lactate, which is considered to be the gold standard for assessing tissue hypoxia, were studied...
April 2013: Pediatrics International: Official Journal of the Japan Pediatric Society
Yoshihiro Wada, Mitsuhiro Uchiba, Yoshiaki Kawano, Nobuyuki Kai, Wataru Takahashi, Jiro Honda, Ken-Ichiro Tanoue, Yoshihiro Maeda, Yoji Murakami, Masatoshi Eto, Takahisa Imamura
UNLABELLED: HASH(0x2f70fd8) INTRODUCTION: Disseminated intravascular coagulation causes thrombotic tendency leading to multiple organ failure and occurs in a wide variety of diseases including malignancy. Disseminated intravascular coagulation is a latent complication in people with prostate cancer. CASE PRESENTATION: A 51-year-old Japanese man with advanced castration-resistant prostate cancer was admitted to our hospital because of extensive purpura and severe anemia...
2012: Journal of Medical Case Reports
Koji Hirano, Shutaro Takashima, Nobuhiro Dougu, Yoshiharu Taguchi, Takamasa Nukui, Hirohumi Konishi, Shigeo Toyoda, Isao Kitajima, Kortaro Tanaka
BACKGROUND: We studied the usefulness of hemostatic biomarkers in assessing the pathology of thrombus formation, subtype diagnosis, prognosis in the acute phase of cerebral infarction, and differences between various hemostatic biomarkers. METHODS: Our study included 69 patients with acute cerebral infarction who had been hospitalized within 2 days of stroke onset. Fibrin monomer complex (FMC), soluble fibrin (SF), D-dimer, thrombin-antithrombin III complex, fibrinogen, antithrombin III, and fibrin/fibrinogen degradation products (FDPs) were assayed as hemostatic biomarkers on days 1, 2, 3, and 7 of hospitalization...
July 2012: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Tsuyoshi Hatada, Hideo Wada, Kazuo Kawasugi, Kohji Okamoto, Toshimasa Uchiyama, Shigeki Kushimoto, Yoshinobu Seki, Takashi Okamura, Hiroshi Imai, Toshihiro Kaneko, Tsutomu Nobori
Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), d-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, d-dimer, and SFMC were recommended to be 8...
September 2012: Clinical and Applied Thrombosis/hemostasis
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