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https://www.readbyqxmd.com/read/29399824/atlantic-mammal-traits-a-data-set-of-morphological-traits-of-mammals-in-the-atlantic-forest-of-south-america
#1
Fernando Gonçalves, Ricardo S Bovendorp, Gabrielle Beca, Carolina Bello, Raul Costa-Pereira, Renata L Muylaert, Raisa R Rodarte, Nacho Villar, Rafael Souza, Maurício E Graipel, Jorge J Cherem, Deborah Faria, Julio Baumgarten, Martín R Alvarez, Emerson M Vieira, Nilton Cáceres, Renata Pardini, Yuri L R Leite, Leonora P Costa, Marco A R Mello, Erich Fischer, Fernando C Passos, Luiz H Varzinczak, Jayme A Prevedello, Ariovaldo P Cruz-Neto, Fernando Carvalho, Alexandre R Percequillo, Agustin Paviolo, Alessandra Nava, José M B Duarte, Noé U de la Sancha, Enrico Bernard, Ronaldo G Morato, Juliana F Ribeiro, Rafael G Becker, Gabriela Paise, Paulo S Tomasi, Felipe Vélez-Garcia, Geruza L Melo, Jonas Sponchiado, Felipe Cerezer, Marília A S Barros, Albérico Q S de Souza, Cinthya C Dos Santos, Gastón A F Giné, Patricia Kerches-Rogeri, Marcelo M Weber, Guilherme Ambar, Lucía V Cabrera-Martinez, Alan Eriksson, Maurício Silveira, Carolina F Santos, Lucas Alves, Eder Barbier, Gabriela C Rezende, Guilherme S T Garbino, Élson O Rios, Adna Silva, Alexandre Túlio A Nascimento, Rodrigo S de Carvalho, Anderson Feijó, Juan Arrabal, Ilaria Agostini, Daniela Lamattina, Sebastian Costa, Ezequiel Vanderhoeven, Fabiano R de Melo, Plautino de Oliveira Laroque, Leandro Jerusalinsky, Mônica M Valença-Montenegro, Amely B Martins, Gabriela Ludwig, Renata B de Azevedo, Agustin Anzóategui, Marina X da Silva, Marcela Figuerêdo Duarte Moraes, Alexandre Vogliotti, Andressa Gatti, Thomas Püttker, Camila S Barros, Thais K Martins, Alexine Keuroghlian, Donald P Eaton, Carolina L Neves, Marcelo S Nardi, Caryne Braga, Pablo R Gonçalves, Ana Carolina Srbek-Araujo, Poliana Mendes, João A de Oliveira, Fábio A M Soares, Patrício A Rocha, Peter Crawshaw, Milton C Ribeiro, Mauro Galetti
Measures of traits are the basis of functional biological diversity. Numerous works consider mean species-level measures of traits while ignoring individual variance within species. However, there is a large amount of variation within species and it is increasingly apparent that it is important to consider trait variation not only between species, but also within species. Mammals are an interesting group for investigating trait-based approaches because they play diverse and important ecological functions (e...
February 2018: Ecology
https://www.readbyqxmd.com/read/29380169/ticks-infesting-cattle-and-humans-in-the-yungas-biogeographic-province-of-argentina-with-notes-on-the-presence-of-tick-borne-bacteria
#2
María N Saracho-Bottero, Evelina L Tarragona, Patrick S Sebastian, José M Venzal, Atilio J Mangold, Alberto A Guglielmone, Santiago Nava
This study was performed to determine the tick species that infest cattle and humans throughout an altitudinal gradient in the Yungas Biogeographic Province of Argentina. The presence of tick-borne bacteria of the genera Rickettsia, Ehrlichia and Borrelia in the collected ticks was also evaluated. Samples of ticks parasitizing cattle and humans were carried out in different seasons. Questing ticks (adults and nymphs) were collected from vegetation and analyzed to detect the presence of Rickettsia, Ehrlichia and Borrelia by a battery of different PCRs...
January 27, 2018: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29368343/ecological-characterization-of-a-tick-community-across-a-landscape-gradient-exhibiting-differential-anthropogenic-disturbance-in-the-atlantic-forest-ecoregion-in-argentina
#3
D Lamattina, J M Venzal, S A Costa, J P Arrabal, S Flores, P E Berrozpe, D González-Acuña, A A Guglielmone, S Nava
An ecological analysis of a tick (Ixodida: Ixodidae) community across a landscape gradient presenting differential anthropogenic disturbance in the Atlantic Forest ecoregion in Argentina was performed. Ticks were collected from vegetation and hosts between September 2014 and August 2016. A total of 12 697 free-living ticks and 3347 specimens from hosts were collected, including 317 ticks infesting humans. The values obtained show considerable species diversity in the forest environment accompanied by low equitability...
January 25, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29352964/c24-hydroxylated-stigmastane-derivatives-as-liver-x-receptor-agonists
#4
Francisco Fermin Castro Navas, Gianluca Giorgi, Daniela Maggioni, Manuela Pacciarini, Vincenzo Russo, Maura Marinozzi
Phytosterols are stucturally correlated to the endogenous ligands of Liver X Receptor (LXR), a ligand-activated nuclear receptor that has emerged as an attractive drug target due to its ability to integrate metabolic and inflammatory signaling. Natural and semi-synthetic phytosterol derivatives characterized by the presence of side-chain oxygenated functions have shown to be able to modulate LXR activity. Here, we describe the efficient synthesis of four stigmastane derivatives, endowed with a hydroxyl group at C24 position, namely (24R)- and (24S)-stigmasta-5,28-diene-3β,24-ols (also referred to as saringosterols, 10a and 10b) and (24R)- and (24S)-stigmasta-5-ene-3β,24-ols (11a and 11b), starting from the readily available stigmasterol...
January 15, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29342184/species-delimitation-in-the-stenocereus-griseus-cactaceae-species-complex-reveals-a-new-species-s-huastecorum
#5
Hernán Alvarado-Sizzo, Alejandro Casas, Fabiola Parra, Hilda Julieta Arreola-Nava, Teresa Terrazas, Cristian Sánchez
The Stenocereus griseus species complex (SGSC) has long been considered taxonomically challenging because the number of taxa belonging to the complex and their geographical boundaries remain poorly understood. Bayesian clustering and genetic distance-based methods were used based on nine microsatellite loci in 377 individuals of three main putative species of the complex. The resulting genetic clusters were assessed for ecological niche divergence and areolar morphology, particularly spination patterns. We based our species boundaries on concordance between genetic, ecological, and morphological data, and were able to resolve four species, three of them corresponding to S...
2018: PloS One
https://www.readbyqxmd.com/read/29323933/cardioventilatory-control-in-preterm-born-children-and-the-risk-of-obstructive-sleep-apnea
#6
Keren Armoni Domany, Md Monir Hossain, Leonardo Nava-Guerra, Michael C Khoo, Keith McConnell, John L Carroll, Yuanfang Xu, Mark DiFrancesco, Raouf S Amin
Rationale The contribution of ventilatory control to the pathogenesis of obstructive sleep apnea (OSA) in preterm born children is unknown. Objectives To characterize phenotypes of ventilatory control that are associated with the presence of OSA in preterm born children during early childhood. Methods Preterm and term born children without comorbid conditions were enrolled. They were categorized into OSA group and non-OSA group based on polysomnography. Measurements Loop gain, controller gain and plant gain, reflecting ventilatory instability, chemoreceptor sensitivity and blood gas response to a change in ventilation, respectively, were estimated from spontaneous sighs identified during polysomnography...
January 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29315614/defining-the-phenotypic-spectrum-of-slc6a1-mutations
#7
Katrine M Johannesen, Elena Gardella, Tarja Linnankivi, Carolina Courage, Anne de Saint Martin, Anna-Elina Lehesjoki, Cyril Mignot, Alexandra Afenjar, Gaetan Lesca, Marie-Thérèse Abi-Warde, Jamel Chelly, Amélie Piton, J Lawrence Merritt, Lance H Rodan, Wen-Hann Tan, Lynne M Bird, Mark Nespeca, Joseph G Gleeson, Yongjin Yoo, Murim Choi, Jong-Hee Chae, Desiree Czapansky-Beilman, Sara Chadwick Reichert, Manuela Pendziwiat, Judith S Verhoeven, Helenius J Schelhaas, Orrin Devinsky, Jakob Christensen, Nicola Specchio, Marina Trivisano, Yvonne G Weber, Caroline Nava, Boris Keren, Diane Doummar, Elise Schaefer, Sarah Hopkins, Holly Dubbs, Jessica E Shaw, Laura Pisani, Candace T Myers, Sha Tang, Shan Tang, Deb K Pal, John J Millichap, Gemma L Carvill, Kathrine L Helbig, Oriano Mecarelli, Pasquale Striano, Ingo Helbig, Guido Rubboli, Heather C Mefford, Rikke S Møller
OBJECTIVE: Pathogenic SLC6A1 variants were recently described in patients with myoclonic atonic epilepsy (MAE) and intellectual disability (ID). We set out to define the phenotypic spectrum in a larger cohort of SCL6A1-mutated patients. METHODS: We collected 24 SLC6A1 probands and 6 affected family members. Four previously published cases were included for further electroclinical description. In total, we reviewed the electroclinical data of 34 subjects. RESULTS: Cognitive development was impaired in 33/34 (97%) subjects; 28/34 had mild to moderate ID, with language impairment being the most common feature...
January 8, 2018: Epilepsia
https://www.readbyqxmd.com/read/29288679/the-gene-product-of-a-trypanosoma-equiperdum-ortholog-of-the-camp-dependent-protein-kinase-regulatory-subunit-is-a-monomeric-protein-that-is-not-capable-of-binding-cyclic-nucleotides
#8
José Bubis, Juan Carlos Martínez, Maritza Calabokis, Joilyneth Ferreira, Carlos E Sanz-Rodríguez, Victoria Navas, José Leonardo Escalona, Yurong Guo, Susan S Taylor
The full gene sequence encoding for the Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase (PKA) regulatory (R) subunits was cloned. A poly-His tagged construct was generated [TeqR-like(His)8], and the protein was expressed in bacteria and purified to homogeneity. The size of the purified TeqR-like(His)8 was determined to be ∼ 57,000 Da by molecular exclusion chromatography indicating that the parasite protein is a monomer. Limited proteolysis with various proteases showed that the T. equiperdum R-like protein possesses a hinge region very susceptible to proteolysis...
December 27, 2017: Biochimie
https://www.readbyqxmd.com/read/29212732/the-role-of-rituximab-in-chronic-lymphocytic-leukemia-treatment-and-the-potential-utility-of-biosimilars
#9
REVIEW
Jennifer R Brown, Florence Cymbalista, Jeff Sharman, Ira Jacobs, Pilar Nava-Parada, Anthony Mato
Chronic lymphocytic leukemia (CLL) is managed with observation for asymptomatic or clinically silent disease; pharmacologic intervention is generally required for symptomatic patients with clinically significant adenopathy or cytopenia. In the front-line treatment of CLL, the current standard-of-care includes chemotherapy in combination with an anti-CD20 monoclonal antibody (e.g., rituximab, ofatumumab, or obinutuzumab) or ibrutinib as single agent. Despite the evolving treatment paradigm toward targeted therapy, it is likely that rituximab (plus chemotherapy), with or without targeted agents, will retain a significant role in CLL treatment...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29207608/gsta1-diplotypes-affect-busulfan-clearance-and-toxicity-in-children-undergoing-allogeneic-hematopoietic-stem-cell-transplantation-a-multicenter-study
#10
Marc Ansari, Patricia Huezo-Diaz Curtis, Chakradhara Rao S Uppugunduri, Mohammed Aziz Rezgui, Tiago Nava, Vid Mlakar, Laurence Lesne, Yves Théoret, Yves Chalandon, Lee L Dupuis, Tao Schechter, Imke H Bartelink, Jaap J Boelens, Robbert Bredius, Jean-Hugues Dalle, Saba Azarnoush, Petr Sedlacek, Victor Lewis, Martin Champagne, Christina Peters, Henrique Bittencourt, Maja Krajinovic
Busulfan (BU) dose adjustment following therapeutic drug monitoring contributes to better outcome of hematopoietic stem cell transplantation (HSCT). Further improvement could be achieved through genotype-guided BU dose adjustments. To investigate this aspect, polymorphism within glutathione S transferase genes were assessed. Particularly, promoter haplotypes of the glutathione S transferase A1 (GSTA1) were evaluated in vitro, with reporter gene assays and clinically, in a pediatric multi-center study (N =138) through association with BU pharmacokinetics (PK) and clinical outcomes...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29204758/antiphospholipid-antibodies-steroid-dose-arterial-hypertension-relapses-and-late-onset-predict-organ-damage-in-a-population-of-colombian-patients-with-systemic-lupus-erythematosus
#11
Luis F Pinto-Peñaranda, C Muñoz-Grajales, A F Echeverri Garcia, C J Velásquez-Franco, M A Mesa-Navas, M Zuluaga Quintero, S Herrera-Uribe, J D Márquez-Hernández
Organ damage predicts mortality, increased accrual of detriment, and poor quality of life in systemic lupus erythematosus patients. The objective of this study is to determine the damage-free survival and its predictive factors in a population of Colombian subjects. The method used in this study is the retrospective follow-up of a cohort; damage was measured with SLICC/ACR index. Predictors of impairment were assessed by logistic regression and survival analysis. One hundred sixty-one individuals were included; 28...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29170710/validation-of-the-functional-assessment-of-chronic-illness-therapy-spiritual-well-being-expanded-facit-sp-ex-across-english-and-spanish-speaking-hispanics-latinos-results-from-the-hispanic-community-health-study-study-of-latinos-sociocultural-ancillary-study
#12
Carrie E Brintz, Orit Birnbaum-Weitzman, Erin L Merz, Frank J Penedo, Martha L Daviglus, Adelaide L Fortmann, Linda C Gallo, Patricia Gonzalez, Timothy P Johnson, Elena L Navas-Nacher, Marston E Youngblood, Maria M Llabre
The validity of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp) has been examined in primarily non-Hispanics/Latinos with chronic illness. This study assessed the psychometric properties of the non-illness, expanded FACIT-Sp (FACIT-Sp-Ex) in 5,163 U.S. Hispanic/Latino adults. Measures were interviewer-administered in English or Spanish. Confirmatory factor analyses indicated four factors: Meaning, Peace, Faith, and Relational. The scale demonstrated measurement invariance across English and Spanish...
November 2017: Psychology of Religion and Spirituality
https://www.readbyqxmd.com/read/29164144/intensive-care-unit-patients-with-lower-respiratory-tract-nosocomial-infections-the-enirris-project
#13
Gennaro De Pascale, Otavio T Ranzani, Saad Nseir, Jean Chastre, Tobias Welte, Massimo Antonelli, Paolo Navalesi, Eugenio Garofalo, Andrea Bruni, Luis Miguel Coelho, Szymon Skoczynski, Federico Longhini, Fabio Silvio Taccone, David Grimaldi, Helmut J F Salzer, Christoph Lange, Filipe Froes, Antoni Artigas, Emili Díaz, Jordi Vallés, Alejandro Rodríguez, Mauro Panigada, Vittoria Comellini, Luca Fasano, Paolo M Soave, Giorgia Spinazzola, Charles-Edouard Luyt, Francisco Alvarez-Lerma, Judith Marin, Joan Ramon Masclans, Davide Chiumello, Angelo Pezzi, Marcus Schultz, Hafiz Mohamed, Menno Van Der Eerden, Roger A S Hoek, D A M P J Gommers, Marta Di Pasquale, Rok Civljak, Marko Kutleša, Matteo Bassetti, George Dimopoulos, Stefano Nava, Fernando Rios, Fernando G Zampieri, Pedro Povoa, Lieuwe D Bos, Stefano Aliberti, Antoni Torres, Ignacio Martín-Loeches
The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29129917/dengue-virus-reactive-cd8-t-cells-mediate-cross-protection-against-subsequent-zika-virus-challenge
#14
Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J Gorman, Michael S Diamond, Sujan Shresta
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 -/- or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8+ T cells predominantly mediate cross-protective responses to ZIKV...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29100083/high-rate-of-recurrent-de-novo-mutations-in-developmental-and-epileptic-encephalopathies
#15
Fadi F Hamdan, Candace T Myers, Patrick Cossette, Philippe Lemay, Dan Spiegelman, Alexandre Dionne Laporte, Christina Nassif, Ousmane Diallo, Jean Monlong, Maxime Cadieux-Dion, Sylvia Dobrzeniecka, Caroline Meloche, Kyle Retterer, Megan T Cho, Jill A Rosenfeld, Weimin Bi, Christine Massicotte, Marguerite Miguet, Ledia Brunga, Brigid M Regan, Kelly Mo, Cory Tam, Amy Schneider, Georgie Hollingsworth, David R FitzPatrick, Alan Donaldson, Natalie Canham, Edward Blair, Bronwyn Kerr, Andrew E Fry, Rhys H Thomas, Joss Shelagh, Jane A Hurst, Helen Brittain, Moira Blyth, Robert Roger Lebel, Erica H Gerkes, Laura Davis-Keppen, Quinn Stein, Wendy K Chung, Sara J Dorison, Paul J Benke, Emily Fassi, Nicole Corsten-Janssen, Erik-Jan Kamsteeg, Frederic T Mau-Them, Ange-Line Bruel, Alain Verloes, Katrin Õunap, Monica H Wojcik, Dara V F Albert, Sunita Venkateswaran, Tyson Ware, Dean Jones, Yu-Chi Liu, Shekeeb S Mohammad, Peyman Bizargity, Carlos A Bacino, Vincenzo Leuzzi, Simone Martinelli, Bruno Dallapiccola, Marco Tartaglia, Lubov Blumkin, Klaas J Wierenga, Gabriela Purcarin, James J O'Byrne, Sylvia Stockler, Anna Lehman, Boris Keren, Marie-Christine Nougues, Cyril Mignot, Stéphane Auvin, Caroline Nava, Susan M Hiatt, Martina Bebin, Yunru Shao, Fernando Scaglia, Seema R Lalani, Richard E Frye, Imad T Jarjour, Stéphanie Jacques, Renee-Myriam Boucher, Emilie Riou, Myriam Srour, Lionel Carmant, Anne Lortie, Philippe Major, Paola Diadori, François Dubeau, Guy D'Anjou, Guillaume Bourque, Samuel F Berkovic, Lynette G Sadleir, Philippe M Campeau, Zoha Kibar, Ronald G Lafrenière, Simon L Girard, Saadet Mercimek-Mahmutoglu, Cyrus Boelman, Guy A Rouleau, Ingrid E Scheffer, Heather C Mefford, Danielle M Andrade, Elsa Rossignol, Berge A Minassian, Jacques L Michaud
Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized by the co-occurrence of epilepsy and intellectual disability (ID), typically with developmental plateauing or regression associated with frequent epileptiform activity. The cause of DEE remains unknown in the majority of cases. We performed whole-genome sequencing (WGS) in 197 individuals with unexplained DEE and pharmaco-resistant seizures and in their unaffected parents. We focused our attention on de novo mutations (DNMs) and identified candidate genes containing such variants...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29094694/spectroscopic-identification-of-r-process-nucleosynthesis-in-a-double-neutron-star-merger
#16
E Pian, P D'Avanzo, S Benetti, M Branchesi, E Brocato, S Campana, E Cappellaro, S Covino, V D'Elia, J P U Fynbo, F Getman, G Ghirlanda, G Ghisellini, A Grado, G Greco, J Hjorth, C Kouveliotou, A Levan, L Limatola, D Malesani, P A Mazzali, A Melandri, P Møller, L Nicastro, E Palazzi, S Piranomonte, A Rossi, O S Salafia, J Selsing, G Stratta, M Tanaka, N R Tanvir, L Tomasella, D Watson, S Yang, L Amati, L A Antonelli, S Ascenzi, M G Bernardini, M Boër, F Bufano, A Bulgarelli, M Capaccioli, P Casella, A J Castro-Tirado, E Chassande-Mottin, R Ciolfi, C M Copperwheat, M Dadina, G De Cesare, A Di Paola, Y Z Fan, B Gendre, G Giuffrida, A Giunta, L K Hunt, G L Israel, Z-P Jin, M M Kasliwal, S Klose, M Lisi, F Longo, E Maiorano, M Mapelli, N Masetti, L Nava, B Patricelli, D Perley, A Pescalli, T Piran, A Possenti, L Pulone, M Razzano, R Salvaterra, P Schipani, M Spera, A Stamerra, L Stella, G Tagliaferri, V Testa, E Troja, M Turatto, S D Vergani, D Vergani
The merger of two neutron stars is predicted to give rise to three major detectable phenomena: a short burst of γ-rays, a gravitational-wave signal, and a transient optical-near-infrared source powered by the synthesis of large amounts of very heavy elements via rapid neutron capture (the r-process). Such transients, named 'macronovae' or 'kilonovae', are believed to be centres of production of rare elements such as gold and platinum. The most compelling evidence so far for a kilonova was a very faint near-infrared rebrightening in the afterglow of a short γ-ray burst at redshift z = 0...
November 2, 2017: Nature
https://www.readbyqxmd.com/read/29091115/oviposition-of-fruit-flies-diptera-tephritidae-and-its-relation-with-the-pericarp-of-citrus-fruits
#17
N P Dias, D E Nava, M S Garcia, F F Silva, R A Valgas
Fruit flies (Diptera: Tephritidae) represent a threat to fruit growing worldwide, mainly the citrus culture, however, biological studies show that fruit flies are not perfectly adapted to this host. This study investigated oviposition of Anastrepha fraterculus (Wiedemann, 1830) and Ceratitis capitata (Wiedemann, 1824) and its relation with the pericarp of citrus fruits. We evaluated the relationship between depth of oviposition of A. fraterculus and C. capitata and epicarp thickness of orange [Citrus sinensis (L...
October 30, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29068161/dcc-mutation-update-congenital-mirror-movements-isolated-agenesis-of-the-corpus-callosum-and-developmental-split-brain-syndrome
#18
Ashley Pl Marsh, Timothy J Edwards, Charles Galea, Helen M Cooper, Elizabeth C Engle, Saumya S Jamuar, Aurélie Méneret, Marie-Laure Moutard, Caroline Nava, Agnès Rastetter, Gail Robinson, Guy Rouleau, Emmanuel Roze, Megan Spencer-Smith, Oriane Trouillard, Thierry Billette de Villemeur, Christopher A Walsh, Timothy W Yu, Delphine Heron, Elliott H Sherr, Linda J Richards, Christel Depienne, Richard J Leventer, Paul J Lockhart
The deleted in colorectal cancer (DCC) gene encodes the netrin-1 receptor DCC, a transmembrane protein required for the guidance of commissural axons. Germline DCC mutations disrupt the development of predominantly commissural tracts in the central nervous system (CNS) and cause a spectrum of neurological disorders. Monoallelic, missense and predicted loss-of-function DCC mutations cause congenital mirror movements, isolated agenesis of the corpus callosum, or both. Biallelic, predicted loss-of-function DCC mutations cause developmental split brain syndrome...
October 25, 2017: Human Mutation
https://www.readbyqxmd.com/read/29058206/role-of-cardiovascular-magnetic-resonance-in-suspected-cardiac-amyloidosis-late-gadolinium-enhancement-pattern-as-mortality-predictor
#19
M Baroni, S Nava, G Quattrocchi, A Milazzo, C Giannattasio, A Roghi, P Pedrotti
BACKGROUND: Cardiac magnetic resonance (CMR) has gained a central role in the diagnosis of cardiac amyloidosis (CA). While the diagnostic role of a typical late gadolinium enhancement (LGE) pattern (global subendocardial enhancement coupled with accelerated contrast washout) has been identified, evidence is still conflicting regarding the prognostic role of such examination. METHODS AND RESULTS: We retrospectively analysed all patients referring for CMR at Niguarda Hospital (Milan, Italy) from January 2006 to January 2015 for suspected CA...
October 20, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29056103/metabotyping-for-the-development-of-tailored-dietary-advice-solutions-in-a-european-population-the-food4me-study
#20
RANDOMIZED CONTROLLED TRIAL
Clare B O'Donovan, Marianne C Walsh, Clara Woolhead, Hannah Forster, Carlos Celis-Morales, Rosalind Fallaize, Anna L Macready, Cyril F M Marsaux, Santiago Navas-Carretero, S Rodrigo San-Cristobal, Silvia Kolossa, Lydia Tsirigoti, Christina Mvrogianni, Christina P Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Iwona Traczyk, Christian A Drevon, Hannelore Daniel, Yannis Manios, J Alfredo Martinez, Wim H M Saris, Julie A Lovegrove, John C Mathers, Michael J Gibney, Eileen R Gibney, Lorraine Brennan
Traditionally, personalised nutrition was delivered at an individual level. However, the concept of delivering tailored dietary advice at a group level through the identification of metabotypes or groups of metabolically similar individuals has emerged. Although this approach to personalised nutrition looks promising, further work is needed to examine this concept across a wider population group. Therefore, the objectives of this study are to: (1) identify metabotypes in a European population and (2) develop targeted dietary advice solutions for these metabotypes...
October 2017: British Journal of Nutrition
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