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https://www.readbyqxmd.com/read/28344316/gain-in-the-short-arm-of-chromosome-2-2p-induces-gene-overexpression-and-drug-resistance-in-chronic-lymphocytic-leukemia-analysis-of-the-central-role-of-xpo1
#1
A Cosson, E Chapiro, N Bougacha, J Lambert, L Herbi, H-A Cung, C Algrin, B Keren, F Damm, C Gabillaud, M-N Brunelle-Navas, F Davi, H Merle-Béral, M Le Garff-Tavernier, D Roos-Weil, S Choquet, M Uzunov, V Morel, V Leblond, K Maloum, S Leprêtre, P Feugier, C Lesty, J Lejeune, L Sutton, Y Landesman, S A Susin, F Nguyen-Khac
Leukemia accepted article preview online, 27 March 2017. doi:10.1038/leu.2017.100.
March 27, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28314233/suburban-air-quality-human-health-hazard-assessment-of-potentially-toxic-elements-in-pm10
#2
Laura Megido, Beatriz Suárez-Peña, Luis Negral, Leonor Castrillón, Yolanda Fernández-Nava
PM10 samples were collected at two suburban locations in northern Spain, a traffic-industrial suburban (TIS) station located in the coastal city of Gijón and an industrial suburban (IS) station in Langreo, about 25 km inland. The aerosol samples were chemically analysed to determine ambient air concentrations of As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, V and Zn. The results showed that the mean levels of As, Co, Cu, Fe, Mn, Ni, Pb and Se recorded at the IS location were higher than those at the TIS station...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28302679/disrupting-androgen-receptor-signaling-induces-snail-mediated-epithelial-mesenchymal-plasticity-in-prostate-cancer
#3
Lu Miao, Lin Yang, Rui Li, Daniel Nava Rodrigues, Mateus Crespo, Jer-Tsong Hsieh, Wayne D Tilley, Johann S de Bono, Luke A Selth, Ganesh V Raj
Epithelial to mesenchymal plasticity (EMP) has been linked to metastasis, stemness, and drug resistance. In prostate cancer (PCa), EMP has been associated with both suppression and activation of androgen receptor (AR) signaling. Here we investigated the effect of the potent AR antagonist enzalutamide on EMP in multiple preclinical models of PCa and patient tissues. Enzalutamide treatment significantly enhanced the expression of EMP drivers (ZEB1, ZEB2, Snail, Twist, and FOXC2) and mesenchymal markers (N-cadherin, fibronectin, and vimentin) in PCa cells, enhanced PCa cell migration, and induced PCa transformation to a spindle, fibroblast-like morphology...
March 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28297420/thin-film-cdte-detector-for-microdosimetric-study-of-radiation-dose-enhancement-at-gold-tissue-interface
#4
Nava Raj Paudel, Diana Shvydka, E Ishmael Parsai
Presence of interfaces between high and low atomic number (Z) materials, often encountered in diagnostic imaging and radiation therapy, leads to radiation dose perturbation. It is characterized by a very narrow region of sharp dose enhancement at the interface. A rapid falloff of the dose enhancement over a very short distance from the interface makes the experimental dosimetry nontrivial. We use an in-house-built inexpensive thin-film Cadmium Telluride (CdTe) photodetector to study this effect at the gold-tissue interface and verify our experimental results with Monte Carlo (MC) modeling...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28289868/associations-of-vitamin-d-status-with-dietary-intakes-and-physical-activity-levels-among-adults-from-seven-european-countries-the-food4me-study
#5
Yannis Manios, George Moschonis, Christina P Lambrinou, Christina Mavrogianni, Lydia Tsirigoti, Ulrich Hoeller, Franz F Roos, Igor Bendik, Manfred Eggersdorfer, Carlos Celis-Morales, Katherine M Livingstone, Cyril F M Marsaux, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Clara Woolhead, Hannah Forster, Marianne C Walsh, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Jacqueline Hallmann, Mirosław Jarosz, Agnieszka Surwiłło, Iwona Traczyk, Christian A Drevon, Ben van Ommen, Keith Grimaldi, John N S Matthews, Hannelore Daniel, J Alfredo Martinez, Julie A Lovegrove, Eileen R Gibney, Lorraine Brennan, Wim H M Saris, Mike Gibney, John C Mathers
PURPOSE: To report the vitamin D status in adults from seven European countries and to identify behavioural correlates. METHODS: In total, 1075 eligible adult men and women from Ireland, Netherlands, Spain, Greece, UK, Poland and Germany, were included in the study. RESULTS: Vitamin D deficiency and insufficiency, defined as 25-hydroxy vitamin D3 (25-OHD3) concentration of <30 and 30-49.9 nmol/L, respectively, were observed in 3.3 and 30...
March 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28283832/genetic-and-phenotypic-dissection-of-1q43q44-microdeletion-syndrome-and-neurodevelopmental-phenotypes-associated-with-mutations-in-zbtb18-and-hnrnpu
#6
Christel Depienne, Caroline Nava, Boris Keren, Solveig Heide, Agnès Rastetter, Sandrine Passemard, Sandra Chantot-Bastaraud, Marie-Laure Moutard, Pankaj B Agrawal, Grace VanNoy, Joan M Stoler, David J Amor, Thierry Billette de Villemeur, Diane Doummar, Caroline Alby, Valérie Cormier-Daire, Catherine Garel, Pauline Marzin, Sophie Scheidecker, Anne de Saint-Martin, Edouard Hirsch, Christian Korff, Armand Bottani, Laurence Faivre, Alain Verloes, Christine Orzechowski, Lydie Burglen, Bruno Leheup, Joelle Roume, Joris Andrieux, Frenny Sheth, Chaitanya Datar, Michael J Parker, Laurent Pasquier, Sylvie Odent, Sophie Naudion, Marie-Ange Delrue, Cédric Le Caignec, Marie Vincent, Bertrand Isidor, Florence Renaldo, Fiona Stewart, Annick Toutain, Udo Koehler, Birgit Häckl, Celina von Stülpnagel, Gerhard Kluger, Rikke S Møller, Deb Pal, Tord Jonson, Maria Soller, Nienke E Verbeek, Mieke M van Haelst, Carolien de Kovel, Bobby Koeleman, Glen Monroe, Gijs van Haaften, Tania Attié-Bitach, Lucile Boutaud, Delphine Héron, Cyril Mignot
Subtelomeric 1q43q44 microdeletions cause a syndrome associating intellectual disability, microcephaly, seizures and anomalies of the corpus callosum. Despite several previous studies assessing genotype-phenotype correlations, the contribution of genes located in this region to the specific features of this syndrome remains uncertain. Among those, three genes, AKT3, HNRNPU and ZBTB18 are highly expressed in the brain and point mutations in these genes have been recently identified in children with neurodevelopmental phenotypes...
April 2017: Human Genetics
https://www.readbyqxmd.com/read/28279900/electrochemical-oxidation-of-cyanide-on-3d-ti-ruo2-anode-using-a-filter-press-electrolyzer
#7
Tzayam Pérez, Rosa L López, José L Nava, Isabel Lázaro, Guillermo Velasco, Roel Cruz, Israel Rodríguez
The novelty of this communication lies in the use of a Ti-RuO2 anode which has not been tested for the oxidation of free cyanide in alkaline media at concentrations similar to those found in wastewater from the Merrill Crowe process (100 mg L(-1) KCN and pH 11), which is typically used for the recovery of gold and silver. The anode was prepared by the Pechini method and characterized by SEM. Linear sweep voltammetries on a Ti-RuO2 rotating disk electrode (RDE) confirmed that cyanide is oxidized at 0.45 < E < 1...
February 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28264360/new-species-of-the-damselfly-genus-i-argia-i-from-mexico-central-america-and-ecuador-with-an-emphasis-on-costa-rica-insecta-odonata-coenagrionidae
#8
Rosser W Garrison, Natalia VON Ellenrieder
Seven new species of Argia are described, five of which occur in Costa Rica: Argia calverti n. sp. (Holotype ♂, Costa Rica, Cartago Prov., Tapantí Reserve, 1,310 m, 6 vii 1963, F. G. Thompson leg., in FSCA); Argia carolus n. sp. (Holotype ♂, Costa Rica, San José Prov., El Rodeo Biological Reserve, 7 km W of Villa Colón, 9°54' N, 84°16' W, 561 m, 10-13 vii 1990, T. W. Donnelly leg., in FSCA); Argia elongata n. sp. (Holotype ♂, Costa Rica, Cartago Prov., Reventazón river, SE of Turrialba by highway 10, 9°52'56'' N, 83°38'49'' W, 561 m, 10 viii 1979, R...
February 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28262480/presence-of-borrelia-in-different-populations-of-ixodes-pararicinus-from-northwestern-argentina
#9
Maria N Saracho Bottero, Patrick S Sebastian, Luis A Carvalho, Leonor Guardia Claps, Mariano Mastropaolo, Atilio J Mangold, José M Venzal, Santiago Nava
This work was performed to evaluate the presence of Borrelia in different populations of Ixodes pararicinus from northwestern Argentina (Jujuy, Salta and Tucumán provinces). Questing adults and nymphs of I. pararicinus were collected from vegetation, and I. pararicinus nymphs were also collected on birds. Eighty-two ticks were tested for Borrelia presence by PCR targeting the gene flagellin and the rrfA-rrlB intergenic spacer region. Pools of ticks positive to Borrelia were formed by two nymphs collected on Turdus rufiventris in Tucumán, one nymph collected on Syndactyla rufosuperciliata in Jujuy, one nymph collected on Turdus nigriceps in Tucumán, three nymphs collected on T...
February 27, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28249898/defining-cancer-subpopulations-by-adaptive-strategies-rather-than-molecular-properties-provides-novel-insights-into-intratumoral-evolution
#10
Arig Ibrahim-Hashim, Mark Robertson-Tessi, Pedro Enrizues-Navas, Mehdi Damaghi, Yoganand Balagurunathan, Jonathan W Wojtkowiak, Shonagh Russell, Kam Yoonseok, Mark C Lloyd, Marilyn M Bui, Joel S Brown, Alexander Ra Anderson, Robert J Gillies, Robert A Gatenby
Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from different regions of the same tumor, but genetic data alone provide little insight into environmental selection forces and cellular phenotypic adaptations that govern the underlying Darwinian dynamics. In three spontaneous murine cancers (prostate cancers in TRAMP and PTEN mice, pancreatic cancer in KPC mice), we identified two subpopulations with distinct niche-construction adaptive strategies that remained stable in culture: (1) Invasive cells that produce an acidic environment via upregulated aerobic glycolysis, and (2) Non-invasive cells that were angiogenic and metabolically near-normal...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28237909/the-relationship-between-smoking-intensity-and-subclinical-cardiovascular-injury-the-multi-ethnic-study-of-atherosclerosis-mesa
#11
Mahmoud Al Rifai, Andrew P DeFillippis, John W McEvoy, Michael E Hall, Ana Navas Acien, Miranda R Jones, Rachel Keith, Hoda S Magid, Carlos J Rodriguez, Graham R Barr, Emelia J Benjamin, Rose Marie Robertson, Aruni Bhatnagar, Michael J Blaha
BACKGROUND AND AIMS: Modern tobacco regulatory science requires an understanding of which biomarkers of cardiovascular injury are most sensitive to cigarette smoking exposure. METHODS: We studied self-reported current smokers from the Multi-Ethnic Study of Atherosclerosis. Smoking intensity was defined by number of cigarettes/day and urinary cotinine levels. Subclinical cardiovascular injury was assessed using markers of inflammation [high-sensitivity C-reactive protein (hsCRP), interleukin 6 & 2 (IL-2 & IL-6), tumor necrosis factor alpha (TNF-α)], thrombosis (fibrinogen, D-dimer, homocysteine), myocardial injury (troponin T; TnT), endothelial damage (albumin: creatinine ratio), and vascular function [aortic & carotid distensibility, flow-mediated dilation (FMD)]...
March 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28224082/clinical-characteristics-of-adult-patients-with-inborn-errors-of-metabolism-in-spain-a-review-of-500-cases-from-university-hospitals
#12
J Pérez-López, L Ceberio-Hualde, J S García-Morillo, J M Grau-Junyent, A Hermida Ameijeiras, M López-Rodríguez, J C Milisenda, M Moltó Abad, M Morales-Conejo, J J Nava Mateos
Patients with inborn errors of metabolism (IEMs) have become an emerging and challenging group in the adult healthcare system whose needs should be known in order to implement appropriate policies and to adapt adult clinical departments. We aimed to analyze the clinical characteristics of adult patients with IEMs who attend the most important Spanish hospitals caring for these conditions. A cohort study was conducted in 500 patients, categorized by metabolic subtype according to pathophysiological classification...
March 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28211912/dna-methylation-map-in-circulating-leukocytes-mirrors-subcutaneous-adipose-tissue-methylation-pattern-a-genome-wide-analysis-from-non-obese-and-obese-patients
#13
A B Crujeiras, A Diaz-Lagares, J Sandoval, F I Milagro, S Navas-Carretero, M C Carreira, A Gomez, D Hervas, M P Monteiro, F F Casanueva, M Esteller, J A Martinez
The characterization of the epigenetic changes within the obesity-related adipose tissue will provide new insights to understand this metabolic disorder, but adipose tissue is not easy to sample in population-based studies. We aimed to evaluate the capacity of circulating leukocytes to reflect the adipose tissue-specific DNA methylation status of obesity susceptibility. DNA samples isolated from subcutaneous adipose tissue and circulating leukocytes were hybridized in the Infinium HumanMethylation 450 BeadChip...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28172463/p158-pouchitis-in-paediatric-ulcerative-colitis-a%C3%A2-multicentre-longitudinal-cohort-study-from-the-porto-ibd-working-group-of-espghan
#14
C Topf-Olivestone, E Orlanski Meyer, O Ledder, M Friedman, I Dotan, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, E Wine, C Strisciuglio, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, L de Ridder, F Smets, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172462/p278-short-and-long-term-surgical-outcomes-and-pouch-function-following-proctocolectomy-and-pouch-formation-in-paediatric-ulcerative-colitis-a-multicentre-retrospective-cohort-study-from-the-porto-ibd-working-group-of-espghan
#15
E Orlanski Meyer, C Topf-Olivestone, E Shtayer, H Tulchinsky, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, M W Carroll, M Martinelli, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, B Weiss, N Shah, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28130040/-admission-to-intensive-care-for-a-trauma-related-to-alcohol-or-drugs-a-teachable-moment-for-the-beginning-of-a-change
#16
S Cordovilla-Guardia, R Vilar-López, P Lardelli-Claret, J F Navas, F Guerrero-López, E Fernández-Mondéjar
OBJECTIVES: To estimate how many of the trauma patients admitted to ICU would be candidates for a secondary prevention programme for trauma related to alcohol or drug use by brief motivational intervention and to define what factors prevent that intervention being performed. METHODS: All 16-70year old trauma patients (n=242) admitted to ICU in 32 non-consecutive months (November 2011 to March 2015) were included in the study, coinciding with the implementation of a screening and brief motivational intervention programme for trauma patients related to substance consumption...
January 24, 2017: Enfermería Intensiva
https://www.readbyqxmd.com/read/28118729/the-role-of-affect-driven-impulsivity-in-gambling-cognitions-a-convenience-sample-study-with-a-spanish-version-of-the-gambling-related-cognitions-scale
#17
Francesco Del Prete, Trevor Steward, Juan F Navas, Fernando Fernández-Aranda, Susana Jiménez-Murcia, Tian P S Oei, José C Perales
Background and aims Abnormal cognitions are among the most salient domain-specific features of gambling disorder. The aims of this study were: (a) to examine and validate a Spanish version of the Gambling-Related Cognitions Scale (GRCS; Raylu & Oei, 2004) and (b) to examine associations between cognitive distortion levels, impulsivity, and gambling behavior. Methods This study first recruited a convenience sample of 500 adults who had gambled during the previous year. Participants were assessed using the Spanish version of GRCS (GRCS-S) questionnaire, the UPPS-P impulsivity questionnaire, measures of gambling behavior, and potentially relevant confounders...
January 25, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28103156/antibodies-against-henipa-like-viruses-in-brazilian-bats
#18
Jansen de Araujo, Michael K Lo, Azaibi Tamin, Tatiana L Ometto, Luciano M Thomazelli, Marcello S Nardi, Renata F Hurtado, Alessandra Nava, Christina F Spiropoulou, Paul A Rota, Edison L Durigon
Bats are reservoir hosts for many paramyxoviruses, some of which cause human and zoonotic diseases of public health importance. We developed a Nipah virus nucleoprotein enzyme-linked immunosorbent assay to detect cross-reactive antibodies in serum samples from several bat species in Brazil. Our results warrant further investigation of henipa-like virus reservoirs in the Western hemisphere.
April 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28043039/vertical-and-lateral-distribution-of-fallout-137-cs-and-soil-properties-along-representative-toposequences-of-central-rif-morocco
#19
Haytam Mesrar, Abdelhamid Sadiki, Ali Faleh, Laura Quijano, Leticia Gaspar, Ana Navas
The purpose of this study is to understand and quantify the relationships between current (137)Cs inventories and the soil properties and the physiographic characteristics. A total of 36 cores were taken in seven transects with different slopes, lithology and land use. The analysis focused on the (137)Cs mass activity as well as inventories and its relationship with soil properties as grain size and organic matter. The mass activity of (137)Cs and the inventories varied between 3.6 and 63.7 Bq kg(-1) and between 521...
December 30, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28035274/the-strength-of-the-association-between-heterozygosity-and-probability-of-interannual-local-recruitment-increases-with-environmental-harshness-in-blue-tits
#20
Esperanza S Ferrer, Vicente García-Navas, Juan José Sanz, Joaquín Ortego
The extent of inbreeding depression and the magnitude of heterozygosity-fitness correlations (HFC) have been suggested to depend on the environmental context in which they are assayed, but little evidence is available for wild populations. We combine extensive molecular and capture-mark-recapture data from a blue tit (Cyanistes caeruleus) population to (1) analyze the relationship between heterozygosity and probability of interannual adult local recruitment and (2) test whether environmental stress imposed by physiologically suboptimal temperatures and rainfall influence the magnitude of HFC...
December 2016: Ecology and Evolution
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