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https://www.readbyqxmd.com/read/28725925/characterisation-of-peptide5-systemic-administration-for-treating-traumatic-spinal-cord-injured-rats
#1
Yilin Mao, Tara Nguyen, Ryan S Tonkin, Justin G Lees, Caitlyn Warren, Simon J O'Carroll, Louise F B Nicholson, Colin R Green, Gila Moalem-Taylor, Catherine A Gorrie
Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of Peptide5 systemic administration. Rats were subjected to a mild contusion SCI using the New York University impactor. One cohort was injected intraperitoneally with a single dose of fluorescently labelled Peptide5 and euthanised at 2 or 4 h post-injury for peptide distribution analysis...
July 19, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28716296/clinical-and-radiologic-predictive-factors-of-rib-fractures-in-outpatients-with-chest-pain
#2
REVIEW
Liang Zhang, Colm J McMahon, Samir Shah, Jim S Wu, Ronald L Eisenberg, Justin W Kung
PURPOSE: To identify the clinical and radiologic predictive factors of rib fractures in stable adult outpatients presenting with chest pain and to determine the utility of dedicated rib radiographs in this population of patients. METHOD AND MATERIALS: Following Institutional Review Board approval, we performed a retrospective review of 339 consecutive cases in which a frontal chest radiograph and dedicated rib series had been obtained for chest pain in the outpatient setting...
May 30, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28698756/treatment-of-decubitis-ulcer-stage-iv-in-the-patient-with-polytrauma-and-vertical-share-pelvic-fracture-diagnosed-entherocollitis-and-deep-wound-infection-with-clostridium-difficile-with-combined-negative-pressure-wound-therapy-npwt-and-faecal-management-system
#3
Slavcho Stojmenski, Igor Merdzanovski, Andrej Gavrilovski, Sofija Pejkova, Gjorge Dzokic, Smilja Tudzarova
AIM: The aim of this paper was to present a case with the successful treatment of decubitis ulcer stage IV in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with Clostridium difficile treated with combined Negative Pressure Wound Therapy (NPWT) and faecal management system. CASE REPORT: Patient D.S.1967 treated on Traumatology Clinic after tentamen suicide on 9.2.2015 with diagnosis: brain contusion; contusion of thoracal space; vertical share pelvic fracture; open fracture type II of the right calcaneus; fracture of the left calcaneus; fracture on the typical place of the left radius; fracture of the right radius with dislocation...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28696855/don-t-forget-the-abdominal-wall-imaging-spectrum-of-abdominal-wall-injuries-after-nonpenetrating-trauma
#4
Shanna A Matalon, Reza Askari, Jonathan D Gates, Ketan Patel, Aaron D Sodickson, Bharti Khurana
Abdominal wall injuries occur in nearly one of 10 patients coming to the emergency department after nonpenetrating trauma. Injuries range from minor, such as abdominal wall contusion, to severe, such as abdominal wall rupture with evisceration of abdominal contents. Examples of specific injuries that can be detected at cross-sectional imaging include abdominal muscle strain, tear, or hematoma, including rectus sheath hematoma (RSH); traumatic abdominal wall hernia (TAWH); and Morel-Lavallée lesion (MLL) (closed degloving injury)...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28696288/inhibition-of-the-integrated-stress-response-reverses-cognitive-deficits-after-traumatic-brain-injury
#5
Austin Chou, Karen Krukowski, Timothy Jopson, Ping Jun Zhu, Mauro Costa-Mattioli, Peter Walter, Susanna Rosi
Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet the mechanisms underlying the chronic cognitive deficits associated with TBI remain unknown. Consequently, there are no effective treatments for patients suffering from the long-lasting symptoms of TBI. Here, we show that TBI persistently activates the integrated stress response (ISR), a universal intracellular signaling pathway that responds to a variety of cellular conditions and regulates protein translation via phosphorylation of the translation initiation factor eIF2α...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28674910/diagnostic-imaging-in-pediatric-thoracic-trauma
#6
Claudia Lucia Piccolo, Stefania Ianniello, Margherita Trinci, Michele Galluzzo, Michele Tonerini, Massimo Zeccolini, Giuseppe Guglielmi, Vittorio Miele
Thoracic trauma accounts for approximately 14% of blunt force traumatic deaths, second only to head injuries. Chest trauma can be blunt (90% of cases) or penetrating. In young patients, between 60 and 80% of chest injuries result from blunt trauma, with over half as a consequence of impact with motor vehicles, whereas in adolescents and adults, penetrating trauma has a statistically more prominent role. Pulmonary contusions and rib fractures are the most frequent injuries occurring. Chest X-ray is the first imaging modality of choice to identify patients presenting with life-threatening conditions (i...
July 4, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28672950/tocotrienol-alleviates-inflammation-and-oxidative-stress-in-a-rat-model-of-spinal-cord-injury-via-suppression-of-transforming-growth-factor-%C3%AE
#7
Chuanhui Xun, Mardan Mamat, Hailong Guo, Pulat Mamati, Jun Sheng, Jian Zhang, Tao Xu, Weidong Liang, Rui Cao, Weibin Sheng
In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the effect of tocotrienols on spinal cord injury (SCI) by evaluating oxidative stress, inflammation and inducible nitric oxide synthase (iNOS) in rats. A rat model of SCI was induced by operation. SCI rats were treated with 120 mg/kg/day tocotrienol once a day for eight consecutive weeks...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28665182/systemic-administration-of-exosomes-released-from-mesenchymal-stromal-cells-attenuates-apoptosis-inflammation-and-promotes-angiogenesis-after-contusion-spinal-cord-injury-in-rats
#8
Jiang-Hu Huang, Xiao-Ming Yin, Yang Xu, Chun-Cai Xu, Xi Lin, Fu-Biao Ye, Yong Cao, Fei-Yue Lin
Spinal cord injury (SCI) is one of the most common devastating injuries, which causes permanent disabilities such as paralysis and loss of movement or sensation. The precise pathogenic mechanisms of the disease remain unclear, and as of yet, there is no effective cure. Mesenchymal stem cells (MSCs) show promise as an effective therapy in the experimental models of SCI. MSCs secrete various factors which can modulate a hostile environment, which is called the paracrine effect. Among these paracrine molecules, exosome is considered to be the most valuable therapeutic factor...
June 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28662892/glibenclamide-pretreatment-protects-against-chronic-memory-dysfunction-and-glial-activation-in-rat-cranial-blast-traumatic-brain-injury
#9
Jesse A Stokum, Kaspar Keledjian, Erik Hayman, Jason K Karimy, Adam Pampori, Ziyan Imran, Seung Kyoon Woo, Volodymyr Gerzanich, J Marc Simard
Blast traumatic brain injury (bTBI) affects both military and civilian populations, and often results in chronic deficits in cognition and memory. Chronic glial activation after bTBI has been linked with cognitive decline. Pharmacological inhibition of sulfonylurea receptor 1 (SUR1) with glibenclamide was shown previously to reduce glial activation and improve cognition in contusive models of CNS trauma, but has not been examined in bTBI. We postulated that glibenclamide would reduce chronic glial activation and improve long-term memory function after bTBI...
June 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28655679/tetanus-associated-with-road-accidents-in-the-infectious-diseases-department-of-point-g-university-hospital-bamako-mali
#10
A M Traoré, I Coulibaly, G Dabo, H Cissé, K Diallo, A Soukho-Kaya, M D Diango, T Cissé, M Dembélé, H A Traoré, E Pichard, D K Minta
The aim of this study was to describe the epidemiological, clinical, and prognostic aspects of tetanus associated with road accidents and to make recommendations. This observational study collected retrospective clinical data over a 9-year period about adults admitted for trismus and/or generalized or localized paroxysm after a road accident. The study included 25 patients, accounting for 22.12 % of all tetanus cases. Men were massively overrepresented (sex-ratio M/F: 24/1). The median age was 34 ± 8 years...
June 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28652756/noncontact-plating-technique-in-an-open-fracture
#11
Ümit Tuhanioğlu, Hasan Ulaş Oğur, Hakan Çiçek, Fırat Seyfettinoğlu, Osman Çiloğlu, Ahmet Kapukaya
AIM: In comparison with closed fractures, open fractures have an increased risk of infection, there are soft tissue-related problems, and difficulties are experienced in union. The aim of this study was to evaluate and discuss the results of osteosynthesis applied with a noncontact plate in Gustilo-Anderson Type 2, 3a, and 3b fractures. METHOD: The study included 23 patients applied with debridement + noncontact plate osteosynthesis + soft tissue procedures in a single session for the treatment of an open fracture...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28642891/safety-tolerability-of-the-anti-semaphorin-4d-antibody-vx15-2503-in-a-randomized-phase-1-trial
#12
Christopher LaGanke, Lawrence Samkoff, Keith Edwards, Lily Jung Henson, Pavle Repovic, Sharon Lynch, Lael Stone, David Mattson, Aaron Galluzzi, Terrence L Fisher, Christine Reilly, Laurie A Winter, John E Leonard, Maurice Zauderer
OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation, double-blind, placebo-controlled study enrolling adult patients with MS. METHODS: Single IV doses of VX15/2503 or placebo were administered. Ten patients each were randomized (4:1 randomization ratio) into 5 ascending dose cohorts of 1, 3, 6, 10, or 20 mg/kg. Safety, immunogenicity, PK/PD, MRI, ECG, and lymphocyte subset levels were evaluated...
July 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28642177/protective-functions-of-pj34-a-parp-inhibitor-is-related-to-down-regulation-of-calpain-and-nf-%C3%AE%C2%BAb-in-a-mouse-model-of-tbi
#13
Xiaogang Tao, Xuetao Chen, Zonggang Hou, Shuyu Hao, Baiyun Liu
OBJECTIVES: Poly(ADP-ribose) polymerase (PARP), calpain, and nuclear factor-κB (NF-κB) are reported to participate in inflammatory reactions in pathological conditions and are involved in traumatic brain injury. The objective of this study was to investigate whether PARP participated in inflammation related to calpain and NF-κB in a mouse model of controlled cortical impact (CCI). METHODS: PJ34 (10 mg/kg), a selective PARP inhibitor, was administered intraperitoneally 5 min and 8 h after experimental CCI...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28637572/investigating-cyclooxygenase-inhibition-in-a-rat-pulmonary-contusion-model-a-laboratory-study-finding-no-improvement-with-ibuprofen
#14
John P Sharpe, Nick R Khan, Arindam R Chatterjee, Jinsong Huang, Louis J Magnotti, Martin A Croce, Timothy C Fabian
Minimal advances have been made in the management of pulmonary contusions (PCs). The purpose of this study was to evaluate the impact of cyclooxygenase inhibition on outcomes following PC in a rat model. PC was induced in anesthetized adult rats. Ibuprofen was given to the treatment group (TG) and water was given to the control group (CG). Lung injury was assessed with pulse oximetry, arterial blood gases, CT, and histopathologic examination. Inflammation was measured with both serum and bronchoalveolar lavage (BAL) levels of tumor necrosis factor α and interleukin-6...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28633779/differences-in-classification-between-mono-and-polytrauma-and-low-%C3%A2-and-high-energy-trauma-patients-with-an-ankle-fracture-a%C3%A2-retrospective-cohort-study
#15
Jan Paul Briet, Roderick Marijn Houwert, Diederik P J Smeeing, Marcel G W Dijkgraaf, Egbert Jan Verleisdonk, Luke P H Leenen, Falco Hietbrink
Although fracture type and treatment options for ankle fractures are well defined, the differences between mono- and polytrauma patients and low- and high-energy trauma have not been addressed. The aim of the present study was to compare the fracture type and trauma mechanism between mono- and polytrauma and low- and high-energy trauma patients with an ankle fracture. We performed a single-center retrospective cohort study. Fractures were classified according to the Lauge-Hansen classification and a descriptive classification...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28629741/establishment-of-an-ideal-time-window-model-in-hypothermic-targeted-temperature-management-after-traumatic-brain-injury-in-rats
#16
Wan-Yong Zhao, Shao-Bo Chen, Jing-Jing Wang, Chao Xu, Ming-Liang Zhao, Hua-Jiang Dong, Hai-Qian Liang, Xiao-Hong Li, Yue Tu, Sai Zhang, Chong Chen, Hong-Tao Sun
Although hypothermic-targeted temperature management (HTTM) holds great potential for the treatment of traumatic brain injury (TBI), translation of the efficacy of hypothermia from animal models to TBI patientshas no entire consistency. This study aimed to find an ideal time window model in experimental rats which was more in accordance with clinical practice through the delayed HTTM intervention. Sprague-Dawley rats were subjected to unilateral cortical contusion injury and received therapeutic hypothermia at 15 mins, 2 hours, 4 hours respectively after TBI...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28623671/feasibility-of-diffusion-tensor-imaging-for-assessing-functional-recovery-in-rats-with-olfactory-ensheathing-cell-transplantation-after-contusive-spinal-cord-injury-sci
#17
Mengchao Gu, Zhengchao Gao, Xiaohui Li, Feng Zhao, Lei Guo, Jiantao Liu, Xijing He
BACKGROUND Olfactory ensheathing cell transplantation is a promising treatment for spinal cord injury. Diffusion tensor imaging has been applied to assess various kinds of spinal cord injury. However, it has rarely been used to evaluate the beneficial effects of olfactory ensheathing cell transplantation. This study aimed to explore the feasibility of diffusion tensor imaging in the evaluation of functional recovery in rats with olfactory ensheathing cell transplantation after contusive spinal cord injury. MATERIAL AND METHODS Immunofluorescence staining was performed to determine the purity of olfactory ensheathing cells...
June 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28616231/lymph-node-transfer-for-refractory-infectious-sites-caused-by-trauma
#18
Makoto Mihara, Hisako Hara, Kazuki Kikuchi
OBJECTIVE: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection. CASE AND RESULTS: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. After conservative treatment, we transferred a lymph-node-containing free superficial circumflex iliac artery perforator flap to the region, with minimum debridement...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28601045/microrna-494-improves-functional-recovery-and-inhibits-apoptosis-by-modulating-pten-akt-mtor-pathway-in-rats-after-spinal-cord-injury
#19
Huaguang Zhu, Rong Xie, Xiaodong Liu, Jiajun Shou, Wentao Gu, Shixin Gu, Xiaoming Che
Multiple cellular, molecular, and biochemical changes contribute to the etiology and treatment outcome of contusion spinal cord injury (SCI). MicroRNAs (miRNAs) aberrant expression have been found after SCI in recent studies. However, little is known about the functional significance of the unique role of miRNAs in SCI. Here, we established a rat SCI model and performed the miRNA microarray to analyze miRNAs expression at different times post-SCI. Microarray data revealed that 14 miRNAs were upregulated and 46 miRNAs were downregulated by 2 times compared with sham rat spinal cords, and miR-494 was one of the miRNAs being most significantly downregulated...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28598857/sdf-1-overexpression-by-mesenchymal-stem-cells-enhances-gap-43-positive-axonal-growth-following-spinal-cord-injury
#20
Andrew Nathaniel Stewart, Jessica Jane Matyas, Ryan Matthew Welchko, Alison Delanie Goldsmith, Sarah Elizabeth Zeiler, Ute Hochgeschwender, Ming Lu, Zhenhong Nan, Julien Rossignol, Gary Leo Dunbar
PURPOSE: Utilizing genetic overexpression of trophic molecules in cell populations has been a promising strategy to develop cell replacement therapies for spinal cord injury (SCI). Over-expressing the chemokine, stromal derived factor-1 (SDF-1α), which has chemotactic effects on many cells of the nervous system, offers a promising strategy to promote axonal regrowth following SCI. The purpose of this study was to explore the effects of human SDF-1α, when overexpressed by mesenchymal stem cells (MSCs), on axonal growth and motor behavior in a contusive rat model of SCI...
June 6, 2017: Restorative Neurology and Neuroscience
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