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treatment of contusions

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https://www.readbyqxmd.com/read/28326040/effects-of-topical-icing-on-inflammation-angiogenesis-revascularization-and-myofiber-regeneration-in-skeletal-muscle-following-contusion-injury
#1
Daniel P Singh, Zohreh Barani Lonbani, Maria A Woodruff, Tony J Parker, Roland Steck, Jonathan M Peake
Contusion injuries in skeletal muscle commonly occur in contact sport and vehicular and industrial workplace accidents. Icing has traditionally been used to treat such injuries under the premise that it alleviates pain, reduces tissue metabolism, and modifies vascular responses to decrease swelling. Previous research has examined the effects of icing on inflammation and microcirculatory dynamics following muscle injury. However, whether icing influences angiogenesis, collateral vessel growth, or myofiber regeneration remains unknown...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28320049/d-%C3%AE-hydroxybutyrate-promotes-functional-recovery-and-relieves-pain-hypersensitivity-in-mice-with-spinal-cord-injury
#2
Jiao Qian, Wenjun Zhu, Ming Lu, Bin Ni, Jun Yang
BACKGROUND AND PURPOSE: Spinal cord injury (SCI) leads to severe motor and sensory dysfunction and significantly reduces the quality of life. The aim of present work was to investigate the effect of administration of exogenous D-β-hydroxybutyrate (DBHB) on functional recovery and neuropathic pain in spinal-cord-injured mice. EXPERIMENTAL APPROACH: Mice were given a moderate-severe thoracic spinal contusion injury at the T9-10 level, and treated with exogenous DBHB...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28314418/facial-injuries-in-sports-soft-tissue-injuries-abrasions-contusions-lacerations
#3
REVIEW
Guy L Lanzi
This article reviews the diagnosis and treatment of facial soft tissue injuries in athletics. General diagnostic algorithms are presented, including initial assessment aligned with Advanced Trauma Life Support guidelines. Specific injury types are discussed along with possible collateral damage and adverse sequelae to limit morbidity. Treatment modalities are described using generally accepted principles refined to fit athlete patients. Return-to-play issues are outlined relative to level of participation, with the emphasis on safe return...
April 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28294065/tetramethylpyrazine-facilitates-functional-recovery-after-spinal-cord-injury-by-inhibiting-mmp2-mmp9-and-vascular-endothelial-cell-apoptosis
#4
Jian-Zhong Hu, Xiao-Kai Wang, Yong Cao, Dong-Zhe Li, Tian-Ding Wu, Tao Zhang, Da-Qi Xu, Hong-Bin Lu
BACKGROUND: Spinal cord injury (SCI) is a major public health issue that leads to neurological dysfunctions and morbidities in patients. Tetramethylpyrazine (TMP) plays a neuroprotective role in SCI; however, the underlying mechanism has not been fully elucidated. Objective In the present study, we aimed to investigate the mechanisms and therapeutic effects of TMP on SCI. METHODS: A contusion SCI model was established that used a modified Allen's method. In the TMP group, TMP (200 mg/kg) was injected daily for 5 days post-injury, while in the Negative Control (NC) group, an equal volume of normal saline was injected...
March 13, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28254102/auricular-acupuncture-analgesia-in-thoracic-trauma-a-case-report
#5
Georgios S Papadopoulos, Petros Tzimas, Antonia Liarmakopoulou, Anastasios M Petrou
We report a case of thoracic trauma (rib fractures with pneumothorax and pulmonary contusions) with severe chest pain leading to ineffective ventilation and oxygenation. The patient presented to our emergency department. The patient had chronic obstructive pulmonary disease and was completely unable to take deep breaths and clear secretions from his bronchial tree. After obtaining informed consent, we applied auricular acupuncture to ameliorate pain and hopefully improve his functional ability to cough and breathe deeply...
January 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28241883/the-number-of-displaced-rib-fractures-is-more-predictive-for-complications-in-chest-trauma-patients
#6
Chih-Ying Chien, Yu-Hsien Chen, Shih-Tsung Han, Gerald N Blaney, Ting-Shuo Huang, Kuan-Fu Chen
BACKGROUND: Traumatic rib fractures can cause chest complications that need further treatment and hospitalization. We hypothesized that an increase in the number of displaced rib fractures will be accompanied by an increase in chest complications. METHODS: We retrospectively reviewed the trauma registry between January 2013 and May 2015 in a teaching hospital in northeastern Taiwan. Patients admitted with chest trauma and rib fractures without concomitant severe brain, splenic, pelvic or liver injuries were included...
February 28, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28238848/resveratrol-protects-against-spinal-cord-injury-by-activating-autophagy-and-inhibiting-apoptosis-mediated-by-the-sirt1-ampk-signaling-pathway
#7
Haosen Zhao, Shurui Chen, Kai Gao, Zipeng Zhou, Chen Wang, Zhaoliang Shen, Yue Guo, Zhuo Li, Zhanghui Wan, Chang Liu, Xifan Mei
Spinal cord injury (SCI) is a devastating condition with few effective treatments. Resveratrol, a polyphenolic compound, has exhibited neuroprotective effects in many neurodegenerative diseases. However, the explicit effect and mechanism of resveratrol on SCI is still unclear. Adenosine 5' monophosphate-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1), the downstream protein, play key roles in metabolizing of energy, resisting of resistance, and cellular protein homeostasis. In this study, we determined the effects of resveratrol on SCI and their potential relationship with SIRT1/AMPK signaling pathway, autophagy and apoptosis...
February 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28230585/decompressive-craniectomy-with-bifrontal-coronal-incision-in-the-management-of-fronto-temporal-contusion-and-laceration-for-early-cranioplasty
#8
Zhong Wang, Ning Su, Ri-Le Wu, Yi-Song Zhang, Xiao-Jun Zhang, Jian-Jun Qi, Wei-Ping Zhao, Zhong Zhang, Jun-Qing Wang
The present study aims to explore the effectiveness of decompressive craniectomy with bifrontal coronal incision in the management of severe contusion and laceration of bilateral fronto-temporal lobes, as well as the outcomes of early cranioplasty. The authors performed the bifrontal decompressive craniectomy on 56 patients with contusion and laceration of bilateral frontal and temporal lobes, and their follow-up treatment outcomes were tracked within 6 months using Glasgow Outcome Scale. The results showed that 33 patients (out of 56, 58...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28229571/transnasal-transsphenoidal-brain-injury-by-a-fencing-foil-an-unusual-case-report-and-brief-literature-review
#9
Rafet Özay, Mehmet S Balkan, Çağhan Tönge, Zeki Şekerci
BACKGROUND: In this report, the authors present an unusual case of a 10-year-old child who suffered a severe headache and rhinorrhea that occurred as a result of fencing foil sports injury via transnasal-transsphenoidal (TNTS) pathway. METHODS: Following to trauma, the child had shown neurological symptoms such a pupil dilatation, change in consciousness and mild hemiparesia. Imaging demonstrated destruction of bone structures including posterior wall of sphenoid sinus and anterosuperior part of sella turcica, and also a contusion at right thalamic region...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28213069/a-pilot-study-of-cell-mediated-gene-therapy-for-spinal-cord-injury-in-mini-pigs
#10
Islamov Rustem Robertovich, Sokolov Mikhail Evgenyevich, Bashirov Farid Vagizovich, Fadeev Filip Olegovich, Shmarov Maxim Michaylovich, Naroditskiy Boris Savelyevich, Povysheva Tatyana Vyacheslavovna, Shaymardanova Gulnara Ferdinantovna, Yakupov Radik Albertovich, Chelyshev Yuri Aleksandrovich, Lavrov Igor Aleksandrovich
Currently, in clinical practice there is no efficient way to overcome the sequences of neurodegeneration after spinal cord traumatic injury. Using a new experimental model of spinal cord contusion injury on miniature pigs, we proposed to deliver therapeutic genes encoding vascular endothelial growth factor (VEGF), glial cell line-derived neurotrophic factor (GDNF) and neural cell adhesion molecule (NCAM) to the damaged area, using umbilical cord blood mononuclear cells (UCBC). In this study, genetically engineered UCBC (2×10(6) cells in 200 ml of saline) were injected intrathecally to mini-pigs 10days after SCI...
February 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28194285/cerebral-salt-wasting-syndrome-caused-by-minor-head-injury
#11
Toshiki Fukuoka, Yuko Tsurumi, Arihito Tsurumi
A 34-year-old woman was admitted to hospital after sustaining a head injury in a motor vehicle accident (day 1). No signs of neurological deficit, skull fracture, brain contusion, or intracranial bleeding were evident. She was discharged without symptoms on day 4. However, headache and nausea worsened on day 8, at which time serum sodium level was noted to be 121 mEq/L. Treatment with sodium chloride was initiated, but serum sodium decreased to 116 mEq/L on day 9. Body weight decreased in proportion to the decrease in serum sodium...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28188847/pharmacological-inhibition-of-spinal-cord-injury-stimulated-ribosomal-biogenesis-does-not-affect-locomotor-outcome
#12
Ewa Kilanczyk, Kariena R Andres, Justin Hallgren, Sujata Saraswat Ohri, Marikki Laiho, Scott R Whittemore, Michal Hetman
After unresolved endoplasmic reticulum stress, recovery of protein synthesis including increased expression of ribosomal components and translation factors may induce cell death. Using a mouse model of moderate contusive spinal cord injury (SCI) at the T9 level, upregulation of ribosomal biogenesis was observed in the injury epicenter at 24h after trauma. Such upregulation coincided with endoplasmic reticulum stress response as previously reported in this model. It was also accompanied by changes in expression of many other genes associated with translational regulation...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28186860/traumatic-rib-injury-patterns-imaging-pitfalls-complications-and-treatment
#13
Brett S Talbot, Christopher P Gange, Apeksha Chaturvedi, Nina Klionsky, Susan K Hobbs, Abhishek Chaturvedi
The ribs are frequently affected by blunt or penetrating injury to the thorax. In the emergency department setting, it is vital for the interpreting radiologist to not only identify the presence of rib injuries but also alert the clinician about organ-specific injury, specific traumatic patterns, and acute rib trauma complications that require emergent attention. Rib injuries can be separated into specific morphologic fracture patterns that include stress, buckle, nondisplaced, displaced, segmental, and pathologic fractures...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28182676/the-swimming-test-is-effective-for-evaluating-spasticity-after-contusive-spinal-cord-injury
#14
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Taku Kitamura, Kazuhito Morioka, Yoshinori Ichihara, Toru Doi, Yasuhiro Sawada, Masami Akai, Ryohei Nishimura, Naoki Fujita
Spasticity is a frequent chronic complication in individuals with spinal cord injury (SCI). However, the severity of spasticity varies in patients with SCI. Therefore, an evaluation method is needed to determine the severity of spasticity. We used a contusive SCI model that is suitable for clinical translation. In this study, we examined the feasibility of the swimming test and an EMG for evaluating spasticity in a contusive SCI rat model. Sprague-Dawley rats received an injury at the 8th thoracic vertebra...
2017: PloS One
https://www.readbyqxmd.com/read/28179694/functional-and-anatomical-outcome-in-closed-globe-combat-ocular-injuries
#15
Qamar Ul Islam, Mazhar Ishaq, Amer Yaqub, Muhammad Kamran Saeed
OBJECTIVE: To analyse the pattern, visual and anatomical outcome of closed globe combat-related ocular injuries sustained by troops. METHODS: This retrospective study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan, and comprised patients with ocular injuries from January 2010 to June 2014. Record of each patient was evaluated and demography, mode and type of injury, initial and final visual acuity, associated globe injuries, concomitant non-ocular injuries, type of surgical procedures and complications were endorsed on a pre-devised proforma...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28173736/the-alternative-receptor-for-complement-component-5a-c5ar2-conveys-neuroprotection-in-traumatic-spinal-cord-injury
#16
Patrick Biggins, Faith Brennan, Stephen Taylor, Trent Woodruff, Marc Ruitenberg
This study investigated the role of the secondary receptor for complement activation fragment C5a, C5aR2, in secondary inflammatory pathology following contusive spinal cord injury (SCI) in mice. <i>C5ar2<sup>-/-</sup></i> mice exhibited decreased intraparenchymal TNFα and IL-6 acutely after injury but these reductions did not translate into improved outcomes. We show that loss of C5aR2 leads to increased lesion volumes, reduced myelin sparing and significantly worsened recovery from SCI in <i>C5ar2<sup>-/-</sup></i> animals compared to wild-type (WT) controls...
February 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28163080/neuroprotective-effects-of-lycopene-in-spinal-cord-injury-in-rats-via-antioxidative-and-anti-apoptotic-pathway
#17
Wei Hu, Hongbo Wang, Zhenfeng Liu, Yanlu Liu, Rong Wang, Xiao Luo, Yifei Huang
Oxidative damage induced-mitochondrial dysfunction and apoptosis has been widely studied in spinal cord injury (SCI). Lycopene, a polyunsaturated hydrocarbon, has the highest antioxidant capacity compared to the other carotenoids. However, the role of lycopene in SCI is unknown. In the present study, we evaluated the antioxidant effects of lycopene on mitochondrial dysfunction and apoptosis following T10 contusion SCI in rats. The rats were randomized into 5 groups: the sham group, the SCI group and the SCI pre-treated with lycopene (5, 10, or 20mg/kg) group...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28145928/open-reduction-in-pediatric-condylar-fracture
#18
Alexandre Agostini Barbosa, Ronaldo Célio Mariano
Facial fractures in children are rare. Lack of pneumatization, fat pockets, mixed dentition, contribute to the elasticity and bone stability. When mandibular fractures occur in children, most often involve the condyle by indirect trauma. Such fractures are the center of discussion on the form of treatment if this should be performed conservatively, or held the reduction and fixation of the fracture with surgical exposure of the fragments. In condylar fractures in children, in most patients, the proposed treatment is closed reduction...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28127698/estrogen-attenuates-local-inflammasome-expression-and-activation-after-spinal-cord-injury
#19
Adib Zendedel, Fabian Mönnink, Gholamreza Hassanzadeh, Arash Zaminy, Malek Masoud Ansar, Pardes Habib, Alexander Slowik, Markus Kipp, Cordian Beyer
17-estradiol (E2) is a neuroprotective hormone with a high anti-inflammatory potential in different neurological disorders. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1b) and IL-18 mediated by caspase-1 which is under the control of an intracellular multiprotein complex called inflammasome. We recently described in a SCI model that between 24 and 72 h post-injury, most of inflammasome components including IL-18, IL-1b, NLRP3, ASC, and caspase-1 are upregulated...
January 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28125522/post-traumatic-spinal-hygroma-causing-cord-compression-in-type-iii-odontoid-fracture-with-vertical-atlanto-axial-instability
#20
Salvatore Russo, Antonio Belli, Andy Eynon, Ali Nader-Sepahi
STUDY DESIGN: Case-Report OBJECTIVE.: To report the first case in the literature of a traumatic cervical spine subdural cerebrospinal fluid (CSF) collection (hygroma) under tension causing cord compression. We suggest etio-pathogenesis and modality of treatment. SUMMARY OF BACKGROUND DATA: Hygromas are subdural cranial CSF collection. A literature review showed no previous published case of post-traumatic spinal hygroma. This was a potential life threatening sequelae of a high cervical injury that warranted early diagnosis and emergency treatment...
January 25, 2017: Spine
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