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treatment of contusions

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https://www.readbyqxmd.com/read/29143997/epidermal-neural-crest-stem-cell-derived-glia-enhance-neurotrophic-elements-in-an-ex-vivo-model-of-spinal-cord-injury
#1
Sareh Pandamooz, Mohammad Saied Salehi, Mohammad Ismail Zibaii, Abolhassan Ahmadiani, Mohammad Nabiuni, Leila Dargahi
Growing evidence that cell-based therapies can improve recovery outcome in spinal cord injury (SCI) models substantiates their application for treatment of human with SCI. To address the effectiveness of these stem cells, potential candidates should be evaluated in proper SCI platform that allows direct real-time monitoring. In this study, the role of epidermal neural crest stem cells (EPI-NCSCs) was elucidated in an ex vivo model of SCI and valproic acid (VPA) was administered to ameliorate the inhospitable context of injury for grafted EPI-NCSCs...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29138458/low-intensity-pulsed-ultrasound-improves-behavioral-and-histological-outcomes-after-experimental-traumatic-brain-injury
#2
Wei-Shen Su, Chun-Hu Wu, Szu-Fu Chen, Feng-Yi Yang
The purpose of this study was to investigate the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on behavioral and histological outcomes in a mouse model of traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 weeks. The effects of LIPUS on edema were observed by MR imaging in the mouse brain at 1 and 4 days following TBI. Brain water content, blood-brain barrier permeability, histology analysis, and behavioral studies were performed to assess the effects of LIPUS...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132243/protective-effects-of-estradiol-and-dihydrotestosterone-following-spinal-cord-injury
#3
Dale R Sengelaub, Qi Han, Nai-Kui Liu, Melissa Maczuga, Violetta Szalavari, Stephanie Valencia, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. We previously demonstrated that motoneurons, and the muscles they innervate, show pronounced atrophy after SCI, and these changes are prevented by treatment with testosterone. Here we assessed if the testosterone active metabolites, estradiol and dihydrotestosterone, have similar protective effects after SCI. Young adult female rats received either sham or T9 spinal cord contusion injuries and were treated with estradiol, dihydrotestosterone, both, or nothing via Silastic capsules...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29125102/role-of-methylprednisolone-in-treatment-of-spinal-cord-injured-with-bone-marrow-mesenchymal-stem-cells-transplantation-in-rats-and-its-effect-on-the-expressions-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE
#4
Xin-Ming Yang, Yao-Yu Cheng, Zhen-Liang Zhang, Cong Kang
Objective To investigate the role of methylprednisolone (MP) in treatment of spinal cord injured (SCI) with bone marrow mesenchymal stem cells (BMSCs) transplantation in rats and its effect on the expressions of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) at the local tissues.Methods Forty male Sprague-Dawley(SD) rats were used to establish the models of SCI according to the modified Allen's contusion method and then divided into four groups (n=10 in each group) by using random numbers table:MP group,BMSCs group,BMSCs+MP group,and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29121822/investigation-of-efficacy-of-treatment-in-spinal-cord-injury-erythropoietin-versus-methylprednisolone
#5
Okan Ozkunt, Kerim Sariyilmaz, Halil Can Gemalmaz, Seren Gülsen Gürgen, Ulaş Yener, Fatih Dikici
BACKGROUND: Investigation of the expression of platelet-derived growth factor (PDGF)-β and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP). METHODS: Thirty adult female rats were randomly divided into three even groups. A laminectomy was applied to thoracic ninth vertebra and contusion injury was induced by extradural application of an aneurysm clip...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29115639/oligodendrocyte-precursor-cell-transplantation-promotes-functional-recovery-following-contusive-spinal-cord-injury-in-rats-and-is-associated-with-altered-microrna-expression
#6
Jin Yang, Liu-Lin Xiong, You-Cui Wang, Xiang He, Ling Jiang, Song-Jun Fu, Xue-Fei Han, Jia Liu, Ting-Hua Wang
It has been reported that oligodendrocyte precursor cells (OPCs) may be used to treat contusive spinal cord injury (SCC), and may alter microRNA (miRNA/miR) expression following SCC in rats. However, the association between miRNA expression and the treatment of rats with SCC with OPC transplantation remain unclear. The present study transplanted OPCs into the spinal cord of rats with SCC and subsequently used the Basso, Beattie and Bresnahan (BBB) score to assess the functional recovery and pain scores. An miRNA assay was performed to detect differentially expressed miRNAs in the spinal cord of SCC rats transplanted with OPCs, compared with SCC rats transplanted with medium...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115443/erythropoietin-signaling-increases-neurogenesis-and-oligodendrogenesis-of-endogenous-neural-stem-cells-following-spinal-cord-injury-both-in%C3%A2-vivo-and-in%C3%A2-vitro
#7
Hui Zhang, Xiao Fang, Dake Huang, Qingli Luo, Meijuan Zheng, Kangkang Wang, Le Cao, Zongsheng Yin
Erythropoietin (Epo) promotes functional recovery following spinal cord injury (SCI); however, the exact underlying mechanisms are yet to be determined. Although endogenous neural stem cells (NSCs) in the adult spinal cord are a therapeutic target in SCI models, the effect of Epo on this NSC population remains unknown. The present study investigated the effects of Epo on endogenous NSCs in the adult spinal cord both in vitro and in vivo. For the in vivo analyses, normal rats (Normal) and SCI contusion model rats (SCI) received either recombinant human Epo or saline treatment for 7 days (5,000 U/kg), and spinal cords were subsequently analyzed at 2, 8, and 14 days...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29110567/efficacy-and-tolerability-of-a-new-ibuprofen-200mg-plaster-in-patients-with-acute-sports-related-traumatic-blunt-soft-tissue-injury-contusion
#8
Hans-Georg Predel, Bruno Giannetti, Mark P Connolly, Fraser Lewis, Aomesh Bhatt
BACKGROUND: Ibuprofen is used for the treatment of non-serious pain. This study assessed the efficacy and safety of a new ibuprofen plaster for the treatment of pain associated with acute sports impact injuries/contusions. METHODS: In this randomised, double-blind, multi-centre, placebo controlled, parallel group study, adults (n=130; 18-58 years of age) diagnosed with acute sports-related blunt soft tissue injury/contusion were randomized to receive either ibuprofen 200 mg plaster or placebo plaster...
November 7, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29109234/maresin-1-promotes-inflammatory-resolution-neuroprotection-and-functional-neurological-recovery-after-spinal-cord-injury
#9
Isaac Francos Quijorna, Eva Santos-Nogueira, Karsten Gronert, Aaron B Sullivan, Marcel A Kopp, Benedikt Brommer, Samuel David, Jan M Schwab, Ruben Lopez Vales
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodelling, and leads to functional deficits. Effective treatments for SCI are not currently available. Maresin 1 (MaR1) is a highly conserved specialized pro-resolving mediators (SPM) hosting potent anti-inflammatory and pro-resolving properties with potent tissue regenerative actions. Here, we provide evidence that the inappropriate biosynthesis of SPM in the lesioned spinal cord hampers the resolution of inflammation and leads to deleterious consequences on neurological outcome in adult female mice...
November 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29108471/intranasally-delivered-wnt3a-improves-functional-recovery-after-traumatic-brain-injury-by-modulating-autophagic-apoptotic-and-regenerative-pathways-in-the-mouse-brain
#10
James Ya Zhang, Jinhwan Lee, Xiaohuan Gu, Zheng Wei, Mallory Jessica Harris, Shan Ping P Yu, Ling Wei
Traumatic brain injury (TBI) is a prevalent disorder, but no effective therapies currently exist. An underlying pathophysiology of TBI includes the pathologic elevation of autophagy. β-Catenin, a downstream mediator of the canonical Wnt pathway, is a repressor of autophagy. The Wnt/β-catenin pathway plays a crucial role in cell proliferation and neuronal plasticity/repair in the adult brain. We hypothesized that activation of this pathway could promote neuroprotection and neural regeneration following TBI...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29105465/-the-effect-of-electroacupuncture-combined-with-treadmill-training-on-skeletal-muscle-contusion-in-rats
#11
An-Ning Zhang, Si-Qin Huang, Cheng-Lin Tang, Ao Luo, Dan-Dan Zhao, Quan-Hu Guo, Rui-Qi Gao, Jing Cao
OBJECTIVE: To study the effect and mechanism of electroacupuncture(EA)combined with treadmill training in rats with skeletal muscle contusion. METHODS: A total of sixty Sprague Dawley rats were randomly divided into normal,model, EA, treadmill, and combination groups (n=12/group). The self-made striking device was used to establish skeletal muscle contusion model. EA was applied at "Zusanli" (ST 36) and Ashi point in the EA group. Treadmill was applied to train rats in the treadmill group...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29093636/agmatine-modulates-the-phenotype-of-macrophage-acute-phase-after-spinal-cord-injury-in-rats
#12
Jae Hwan Kim, Jae Young Kim, Chin Hee Mun, Minah Suh, Jong Eun Lee
Agmatine is a decarboxylated arginine by arginine decarboxylase. Agmatine is known to be a neuroprotective agent. It has been reported that agmatine works as a NMDA receptor blocker or a competitive nitric oxide synthase inhibitor in CNS injuries. In spinal cord injury, agmatine showed reduction of neuropathic pain, improvement of locomotor function, and neuroprotection. Macrophage is a key cellular component in neuroinflammation, a major cause of impairment after spinal cord injury. Macrophage has subtypes, M1 and M2 macrophages...
October 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29089998/methotrexate-combined-with-methylprednisolone-for-the-recovery-of-motor-function-and-differential-gene-expression-in-rats-with-spinal-cord-injury
#13
Jian-Tao Liu, Si Zhang, Bing Gu, Hua-Nan Li, Shuo-Yu Wang, Shui-Yin Zhang
Methylprednisolone is a commonly used drug for the treatment of spinal cord injury, but high doses of methylprednisolone can increase the incidence of infectious diseases. Methotrexate has anti-inflammatory activity and immunosuppressive effects, and can reduce inflammation after spinal cord injury. To analyze gene expression changes and the molecular mechanism of methotrexate combined with methylprednisolone in the treatment of spinal cord injury, a rat model of spinal cord contusion was prepared using the PinPoint™ precision cortical impactor technique...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29083257/a-combination-antioxidant-therapy-to-inhibit-nox2-and-activate-nrf2-decreases-secondary-brain-damage-and-improves-functional-recovery-after-traumatic-brain-injury
#14
Raghavendar Chandran, TaeHee Kim, Suresh L Mehta, Eshwar Udho, Vishal Chanana, Pelin Cengiz, HwuiWon Kim, Chanul Kim, Raghu Vemuganti
Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both NADPH oxidase 2 (NOX2) that increases and transcription factor Nrf2 that decreases reactive oxygen species (ROS) are induced after TBI. As the post-injury functional outcome depends on the balance of these opposing molecular pathways, we evaluated the effect of TBI on the motor and cognitive deficits and cortical contusion volume in NOX2 and Nrf2 knockout mice...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29074466/neuroprotective-assessment-of-prolonged-local-hypothermia-post-contusive-spinal-cord-injury-in-rodent-model
#15
Daniel Teh Boon Loong, Soo Min Chua, Ankshita Prasad, Ioannis Kakkos, Wenxuan Jiang, Yue Mu, Xiaogang Liu, Angelo Homayoun All
BACKGROUND CONTEXT: While general hypothermia is recognised as a clinically applicable neuroprotective intervention, acute moderate local hypothermia post-contusive Spinal Cord Injury (SCI) is being considered a more effective approach. Previously, we have investigated the feasibility and safety of inducing prolonged local hypothermia in the Central Nervous System of rodent model. PURPOSE: Here, we aimed to verify the efficacy and neuroprotective effects of 5 and 8 hours local moderate hypothermia (30±0...
October 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29070752/a-surgical-case-of-mesial-temporal-lobe-epilepsy-associated-with-hippocampal-sclerosis-and-traumatic-neocortical-lesion
#16
Yu Kitazawa, Kazutaka Jin, Masaki Iwasaki, Hiroyoshi Suzuki, Fumiaki Tanaka, Nobukazu Nakasato
A 26-year-old right-handed woman, with a history of left temporal lobe contusion caused by a fall at the age of 9 months, started to have complex partial seizures with oral automatism at the age of 7 years. The seizures occurred once or twice a month despite combination therapy with several antiepileptic agents. Her history and imaging studies suggested the diagnosis of epilepsy arising from traumatic neocortical temporal lesion. Comprehensive assessment including long-term video EEG monitoring, MRI, FDG-PET, MEG, and neuropsychological evaluation was performed at the age of 26 years...
October 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29056364/apolipoprotein-e-as-a-novel-therapeutic-neuroprotection-target-after-traumatic-spinal-cord-injury
#17
Xiaoxin Cheng, Yiyan Zheng, Ping Bu, Xiangbei Qi, Chunling Fan, Fengqiao Li, Dong H Kim, Qilin Cao
Apolipoprotein E (apoE), a plasma lipoprotein well known for its important role in lipid and cholesterol metabolism, has also been implicated in many neurological diseases. In this study, we examined the effect of apoE on the pathophysiology of traumatic spinal cord injury (SCI). ApoE-deficient mutant (apoE(-/-)) and wild-type mice received a T9 moderate contusion SCI and were evaluated using histological and behavioral analyses after injury. At 3days after injury, the permeability of spinal cord-blood-barrier, measured by extravasation of Evans blue dye, was significantly increased in apoE(-/-) mice compared to wild type...
October 19, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29054133/effects-of-intrathecal-injection-of-the-conditioned-medium-of-bone-marrow-stromal-cells-on-spinal-cord-injury-of-rats
#18
Kenji Kanekiyo, Tamami Wakabayashi, Norihiko Nakano, Yoshihiro Yamada, Masahiro Tamachi, Yoshihisa Suzuki, Masanori Fukushima, Fukuki Saito, Seiya Abe, Chihiro Tsukagoshi, Chimi Miyamoto, Chizuka Ide
Bone marrow stromal cells (BMSCs) have been studied for the treatment of spinal cord injury (SCI). In previous studies, we showed that the transplantation of BMSCs, even though they disappeared from the host spinal cord within 1-3 weeks after transplantation, improved locomotor behaviors and promoted axonal regeneration. This result led to the hypothesis that BMSCs might release some neurotrophic factors effective for the treatment of SCI. The present study examined this by injecting the conditioned medium (CM) of BMSCs to treat SCI in rats...
October 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29052820/evaluation-of-different-treatment-protocols-for-combined-injury-induced-lung-injury-in-rabbits
#19
Xiao Bing Li
BACKGROUND: This study aims to evaluate the effectiveness of different treatment regimens on combined injury-induced lung injury. METHODS: Rabbits were subjected to non-lethal closed-chest bilateral lung contusion followed by a 30% total body surface area scald burn. The rabbits were randomly assigned to resuscitation groups that maintained a minimum mean arterial blood pressure of 70 mmHg using one of the following three methods: normal saline plus polygeline injection in a ratio of 1:1 (1:1G), normal saline plus polygeline injection in a ratio of 1:2 (1:2G), and normal saline plus polygeline injection in a ratio of 1:3 (1:3G), After injury, lung injury was assessed using lung wet-to-dry (W/D) weight ratio, enzyme-linked immunosorbent assay, and real-time PCR...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29051850/functional-recovery-of-contused-spinal-cord-in-rat-with-the-injection-of-optimal-dosed-cerium-oxide-nanoparticles
#20
Jong-Wan Kim, Chinmaya Mahapatra, Jin-Young Hong, Min Soo Kim, Kam W Leong, Hae-Won Kim, Jung Keun Hyun
Spinal cord injury (SCI) produces excess reactive oxygen species (ROS) that can exacerbate secondary injury and lead to permanent functional impairment. Hypothesizing that cerium oxide nanoparticles (CONPs) as an effective ROS scavenger may offset this damaging effect, it is first demonstrated in vitro that CONPs suppressed inducible nitric oxide synthase (iNOS) generation and enhanced cell viability of hydrogen peroxide (H2O2)-insulted cortical neurons. Next, CONPs are administered at various does (50-4000 µg mL(-1)) to a contused spinal cord rat model and monitored the disease progression for up to eight weeks...
October 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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