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Brain magnetic resonance spectroscopy

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https://www.readbyqxmd.com/read/29456643/multiple-brain-abscesses-caused-by-infection-with-candida-glabrata-a-case-report
#1
Zifeng Zhu, Zhehao Huang, Zhenshengnan Li, Xianglan Li, Chao Du, Yu Tian
The present case report described the initial diagnosis of a 25-year old female with a brain abscess consisting of two lesions 0.2 and 2.9 cm3 in volume. The patient was initially treated with antibiotics; however, 2 months following initial treatment, the patient's condition deteriorated and she became vegetative. Following transfer to the China-Japan Union Hospital of Jilin University (Jilin, China) the two lesions had grown in volume to 9.0 and 13.0 cm3 , respectively. The results of magnetic resonance spectroscopy and plasma 1-3-β-D-glucan activity suggested a possible fungal infection...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29449141/neurometabolites-alteration-in-the-acute-phase-of-mild-traumatic-brain-injury-mtbi-an-in-vivo-proton-magnetic-resonance-spectroscopy-1h-mrs-study
#2
Vigneswaran Veeramuthu, Pohchoo Seow, Vairavan Narayanan, Jeannie Hisu Ding Wong, Li Kuo Tan, Aditya Tri Hernowo, Norlisah Ramli
RATIONALE AND OBJECTIVES: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic insults. We aimed to evaluate the acute alteration of neurometabolites in complicated and uncomplicated mild traumatic brain injury (mTBI) patients in comparison to control subjects using proton magnetic resonance spectroscopy (1H magnetic resonance spectroscopy)...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29446118/water-suppression-in-the-human-brain-with-hypergeometric-rf-pulses-for-single-voxel-and-multi-voxel-mr-spectroscopy
#3
Kimberly L Chan, Ronald Ouwerkerk, Peter B Barker
PURPOSE: To develop and investigate a novel water suppression sequence with hypergeometric pulses at 3 T. METHODS: Simulations were used to optimize the delays and amplitudes of 5 hypergeometric prepulses, to minimize the residual water over a range of T 1 and B 1 values. Single-voxel data with hypergeometric water suppression (HGWS) prepulses were acquired in the centrum semiovale, 2 parietal regions, and insula of 7 subjects, and compared with VAPOR water suppression...
February 14, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29444171/reduced-cognitive-function-increased-blood-brain-barrier-transport-and-inflammatory-responses-and-altered-brain-metabolites-in-ldlr-and-c57bl-6-mice-fed-a-western-diet
#4
Jennifer M Rutkowsky, Linda L Lee, Michelle Puchowicz, Mari S Golub, Douglas E Befroy, Dennis W Wilson, Steven Anderson, Gary Cline, Jason Bini, Kamil Borkowski, Trina A Knotts, John C Rutledge
Recent work suggests that diet affects brain metabolism thereby impacting cognitive function. Our objective was to determine if a western diet altered brain metabolism, increased blood-brain barrier (BBB) transport and inflammation, and induced cognitive impairment in C57BL/6 (WT) mice and low-density lipoprotein receptor null (LDLr -/-) mice, a model of hyperlipidemia and cognitive decline. We show that a western diet and LDLr -/- moderately influence cognitive processes as assessed by Y-maze and radial arm water maze...
2018: PloS One
https://www.readbyqxmd.com/read/29440724/magnetic-resonance-temporal-diffusion-tensor-spectroscopy-of-disordered-anisotropic-tissue
#5
Jonathan Scharff Nielsen, Tim B Dyrby, Henrik Lundell
Molecular diffusion measured with diffusion weighted MRI (DWI) offers a probe for tissue microstructure. However, inferring microstructural properties from conventional DWI data is a complex inverse problem and has to account for heterogeneity in sizes, shapes and orientations of the tissue compartments contained within an imaging voxel. Alternative experimental means for disentangling the signal signatures of such features could provide a stronger link between the data and its interpretation. Double diffusion encoding (DDE) offers the possibility to factor out variation in compartment shapes from orientational dispersion of anisotropic domains by measuring the correlation between diffusivity in multiple directions...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438510/diagnostic-accuracy-of-2-hydroxyglutarate-magnetic-resonance-spectroscopy-in-newly-diagnosed-brain-mass-and-suspected-recurrent-gliomas
#6
Min Zhou, Yue Zhou, Huijun Liao, Benjamin C Rowland, Xiangquan Kong, Nils D Arvold, David A Reardon, Patrick Y Wen, Alexander P Lin, Raymond Y Huang
Background: Isocitrate dehydrogenase (IDH) mutations result in abnormal accumulation of 2-hydroxyglutarate (2HG) in gliomas that can be detected by MRS. We examined the diagnostic accuracy of 2HG single-voxel spectroscopy (SVS) and chemical shift imaging (CSI) in both newly-diagnosed and post-treatment settings. Methods: Long-TE (97 ms) SVS and CSI were acquired in 85 subjects, including a discovery cohort of 39 patients who had postoperative residual or recurrent glioma with confirmed IDH-mutation status and 6 normal volunteers, a prospective preoperative validation cohort of 24 patients with newly-diagnosed brain mass, and a prospective recurrent-lesion validation cohort of 16 previously-treated IDH-mutant glioma patients with suspected tumor recurrence...
February 9, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29436038/comparison-of-reproducibility-of-single-voxel-spectroscopy-and-whole-brain-magnetic-resonance-spectroscopy-imaging-at-3t
#7
Yue Zhang, Edward Taub, Nouha Salibi, Gitendra Uswatte, Andrew A Maudsley, Sulaiman Sheriff, Brent Womble, Victor W Mark, David C Knight
To date, single voxel spectroscopy (SVS) is the most commonly used MRS technique. SVS is relatively easy to use and provides automated and immediate access to the resulting spectra. However, it is also limited in spatial coverage. A new and very promising MRS technique allows for whole-brain MR spectroscopic imaging (WB-MRSI) with much improved spatial resolution. Establishing the reproducibility of data obtained using SVS and WB-MRSI is an important first step for using these techniques to evaluate longitudinal changes in metabolite concentration...
February 13, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29435084/mitigation-of-stress-new-treatment-alternatives
#8
REVIEW
Ahmad Rauf Subhani, Nidal Kamel, Mohamad Naufal Mohamad Saad, Nanda Nandagopal, Kenneth Kang, Aamir Saeed Malik
Complaints of stress are common in modern life. Psychological stress is a major cause of lifestyle-related issues, contributing to poor quality of life. Chronic stress impedes brain function, causing impairment of many executive functions, including working memory, decision making and attentional control. The current study sought to describe newly developed stress mitigation techniques, and their influence on autonomic and endocrine functions. The literature search revealed that the most frequently studied technique for stress mitigation was biofeedback (BFB)...
February 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29428932/metabolite-levels-in-paediatric-brain-tumours-correlate-with-histological-features
#9
Eleni Orphanidou-Vlachou, Sarah E Kohe, Marie-Anne Brundler, Lesley MacPherson, Yu Sun, Nigel Davies, Martin Wilson, Xiaoyan Pan, Theodoros N Arvanitis, Richard G Grundy, Andrew C Peet
AIMS: Metabolite levels can be measured non-invasively using in vivo 1H magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between metabolite values and conventional histopathological characteristics has not yet been fully established. This study systematically tests the relationship between metabolite levels detected by MRS and specific histological features in a range of paediatric brain tumours...
February 10, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29426954/3d-7li-magnetic-resonance-imaging-of-brain-lithium-distribution-in-bipolar-disorder
#10
Fiona Elizabeth Smith, Peter Edward Thelwall, Joe Necus, Carly Jay Flowers, Andrew Matthew Blamire, David Andrew Cousins
Lithium is a major treatment for bipolar disorder and the likelihood of a favourable response may be determined by its distribution in the brain. Lithium can be directly detected by magnetic resonance (MR), but previous 7Li MR spectroscopy studies have demonstrated that this is challenging compared to conventional 1H MR imaging due to the MR properties of the lithium nucleus and its low concentration in brain tissue, as dictated by therapeutic dose. We have tested and implemented a highly efficient balanced steady-state free precession 7Li-MRI method to address these challenges and enable MRI of brain lithium in a short duration scan...
February 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29426888/ice-slurry-ingestion-reduces-human-brain-temperature-measured-using-non-invasive-magnetic-resonance-spectroscopy
#11
Sumire Onitsuka, Daisuke Nakamura, Takahiro Onishi, Takuma Arimitsu, Hideyuki Takahashi, Hiroshi Hasegawa
We previously reported that ice slurry ingestion reduced forehead skin temperature, thereby potentially reducing brain temperature (Tbrain). Therefore, in the current study, we investigated the effect of ice slurry ingestion on Tbrain using proton magnetic resonance spectroscopy, which is a robust, non-invasive method. Eight male participants ingested 7.5 g/kg of either a thermoneutral drink (37 °C; CON) or ice slurry (-1 °C; ICE) for about 5 min following a 15-min baseline period. Then, participants remained at rest for 30 min...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29423350/primary-psychiatric-disorder-masking-the-diagnosis-of-neuropsychiatric-lupus-in-a-patient-with-altered-mental-status-a-case-report
#12
Osman Perez, Kairavee Dave, Aimee Almanzar, Tajul Prodhan, Livasky Concepion
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a wide variety of neurologic and psychiatric features. NPSLE symptoms and the psychotic features of primary psychiatric disorders often overlap with each other. These psychotic features often mask and delay the diagnosis of NPSLE. We present the case of a 59-year-old female previously diagnosed with bipolar disorder and generalized anxiety disorder presenting with altered mental status (AMS), subsequently diagnosed with neuropsychiatric lupus. Initially, medication overdose was suspected as an empty bottle of trazodone was found beside her...
October 23, 2017: Curēus
https://www.readbyqxmd.com/read/29417580/in-vivo-characterization-of-brain-metabolism-by-1-h-mrs-13-c-mrs-and-18-fdg-pet-reveals-significant-glucose-oxidation-of-invasively-growing-glioma-cells
#13
Marta Lai, Irene Vassallo, Bernard Lanz, Carole Poitry-Yamate, Marie-France Hamou, Cristina Cudalbu, Rolf Gruetter, Monika E Hegi
Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of invasively growing glioma xenografts in the mouse brain. Animals were subjected longitudinally to Magnetic Resonance Imaging (MRI) and 1 H spectroscopy (MRS) at ultra high field (14.1 Tesla) that allowed the measurement of 16 metabolic biomarkers to characterize the metabolic profiles...
February 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29417380/assessing-long-term-neuroinflammatory-responses-to-encephalopathy-using-mri-approaches-in-a-rat-endotoxemia-model
#14
Rheal A Towner, D Saunders, N Smith, W Towler, M Cruz, S Do, J E Maher, K Whitaker, M Lerner, K A Morton
Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, and metabolism, respectively, in a rat lipopolysaccharide-induced SAE model. Free radical-targeted molecular MRI was used to detect brain radical levels at 24 h and 1 week post-LPS injection. CE-MRI showed increased Gd-DTPA uptake in LPS rat brains at 24 h in cerebral cortex, hippocampus, thalamus, and perirhinal cortex regions...
February 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29414126/proton-magnetic-resonance-spectroscopy-changes-after-lithium-treatment-systematic-review
#15
REVIEW
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiolek
1H MRS is widely used in the research of mental disorders. It enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: N-acetylaspartate (NAA), choline containing compounds, myo-inositol and glutamate, glutamine and GABA (together as Glx complex or separately). Specifically in bipolar disorder brain metabolite abnormalities include mostly NAA reduces and Glx increases in different brain regions. Bipolar disorder is associated with impairment in neurotrophic and cellular plasticity, resilience pathways and in neuroprotective processes...
January 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29408682/neurochemical-changes-in-unilateral-cerebralhemisphere-during-the-subacute-stage-of-focal-cerebral-ischemia-reperfusion-in-rats-an-ex-vivo-1h-magnetic-resonance-spectroscopy-study
#16
Qun Huang, Chen Li, Nengzhi Xia, Liangcai Zhao, Dan Wang, Yunjun Yang, Hongchang Gao
Understanding the subacute may shed light on the mechanism of cerebral ischemia. The present study aimed to explore metabolic features underlying subacute stage of ischemia-reperfusion injury and developing effective treatments. Rats were divided into three groups: the permanent middle cerebral artery occlusion (pMCAO), transient cerebral focal ischemia (tMCAO) and sham group. Evaluation of animal models was performed by the neurological deficit, MR images and pathological morphological abnormality. To elucidate metabolic changes, we conducted a comparative analysis of metabolic composition of unilateral brain tissue using 1H nuclear magnetic resonance spectroscopy...
January 31, 2018: Brain Research
https://www.readbyqxmd.com/read/29407539/a-pilot-study-of-minocycline-for-the-treatment-of-bipolar-depression-effects-on-cortical-glutathione-and-oxidative-stress-in-vivo
#17
James W Murrough, Kathryn M Huryk, Xiangling Mao, Brian Iacoviello, Katherine Collins, Andrew A Nierenberg, Guoxin Kang, Dikoma C Shungu, Dan V Iosifescu
BACKGROUND: The antibiotic minocycline appears to promote neuroprotection through antioxidant and other mechanisms that may be relevant to the pathophysiology of bipolar disorder. The present study assessed the efficacy of minocycline in bipolar depression and examined the association between minocycline treatment and brain glutathione (GSH), an essential regulator of oxidative stress. METHOD: Twenty patients with bipolar disorder experiencing acute depressive symptoms enrolled in an 8-week, open-label trial of adjuvant minocycline...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29403418/binge-drinking-and-the-young-brain-a-mini-review-of-the-neurobiological-underpinnings-of-alcohol-induced-blackout
#18
REVIEW
Daniel F Hermens, Jim Lagopoulos
Binge drinking has significant effects on memory, particularly with regards to the transfer of information to long-term storage. Partial or complete blocking of memory formation is known as blackout. Youth represents a critical period in brain development that is particularly vulnerable to alcohol misuse. Animal models show that the adolescent brain is more vulnerable to the acute and chronic effects of alcohol compared with the adult brain. This mini-review addresses the neurobiological underpinnings of binge drinking and associated memory loss (blackout) in the adolescent and young adult period...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29400109/evolution-of-the-neurochemical-profiles-in-the-g93a-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#19
Hongxia Lei, Elisabeth Dirren, Carole Poitry-Yamate, Bernard L Schneider, Rolf Gruetter, Patrick Aebischer
In vivo 1H magnetic resonance spectroscopy (1H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neurochemical evolutions of striatum, brainstem and motor cortex of mice transgenic for G93A mutant human superoxide dismutase type-1 (G93A-SOD1), an ALS model. Region-specific neurochemical alterations were detected in asymptomatic G93A-SOD1 mice, particularly in lactate (-19%) and glutamate (+8%) of brainstem, along with γ-amino-butyric acid (-30%), N-acetyl-aspartate (-5%) and ascorbate (+51%) of motor cortex...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29392833/brain-aging-evaluation-of-ph-using-phosphorus-magnetic-resonance-spectroscopy
#20
Monika Cichocka, Justyna Kozub, Andrzej Urbanik
AIM: Very important aspects of aging include age-related changes occurring in the brain. The aim of the present study was to identify the standard pH value in the entire brain volume using phosphorus magnetic resonance spectroscopy in healthy individuals of both sexes in different age groups, and then to determine whether there are differences in these values. METHODS: A total of 65 individuals aged 20-32 years (mean age 24.5 ± 2.1 years, 31 women and 34 men) and 31 individuals aged 60-81 years (mean age 64...
February 2, 2018: Geriatrics & Gerontology International
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