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Liver metastases from colorectal cancer

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https://www.readbyqxmd.com/read/29164382/ct-texture-features-of-liver-parenchyma-for-predicting-development-of-metastatic-disease-and-overall-survival-in-patients-with-colorectal-cancer
#1
Scott J Lee, Ryan Zea, David H Kim, Meghan G Lubner, Dustin A Deming, Perry J Pickhardt
OBJECTIVES: To determine if identifiable hepatic textural features are present at abdominal CT in patients with colorectal cancer (CRC) prior to the development of CT-detectable hepatic metastases. METHODS: Four filtration-histogram texture features (standard deviation, skewness, entropy and kurtosis) were extracted from the liver parenchyma on portal venous phase CT images at staging and post-treatment surveillance. Surveillance scans corresponded to the last scan prior to the development of CT-detectable CRC liver metastases in 29 patients (median time interval, 6 months), and these were compared with interval-matched surveillance scans in 60 CRC patients who did not develop liver metastases...
November 21, 2017: European Radiology
https://www.readbyqxmd.com/read/29125233/in-vivo-imaging-xenograft-models-for-the-evaluation-of-anti-brain-tumor-efficacy-of-targeted-drugs
#2
Kenji Kita, Sachiko Arai, Akihiro Nishiyama, Hirokazu Taniguchi, Koji Fukuda, Rong Wang, Tadaaki Yamada, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Mitsutoshi Nakada, Kazuo Yasumoto, Yoshiharu Motoo, Takashi Murakami, Seiji Yano
Molecular-targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in vivo imaging model for brain tumors using human cancer cell lines, including the EGFR-L858R/T790M-positive H1975 lung adenocarcinoma cells, the NUGC4 hepatocyte growth factor (HGF)-dependent gastric cancer cells, and the KM12SM colorectal cancer cells containing the TPM3-NTRK1 gene fusion...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29113730/conversion-to-resection-in-patients-receiving-systemic-chemotherapy-for-unresectable-and-or-metastatic-colorectal-cancer-predictive-factors-and-prognosis
#3
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Manabu Kaneko, Koji Murono
BACKGROUND: Systemic chemotherapy increases the possibility of resection in patients with initially unresectable colorectal cancer (CRC), especially patients with hepatic metastasis. However, the predictive factors and prognosis of conversion to resection after chemotherapy in patients with various organ metastases remain largely unknown. PATIENTS AND METHODS: We reviewed the data from metastatic CRC (mCRC) patients who had received oxaliplatin- or irinotecan-based systemic chemotherapy from 2005 to 2016...
October 19, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29100312/molecular-signatures-reflecting-microenvironmental-metabolism-and-chemotherapy-induced-immunogenic-cell-death-in-colorectal-liver-metastases
#4
Olga Østrup, Vegar Johansen Dagenborg, Einar Andreas Rødland, Veronica Skarpeteig, Laxmi Silwal-Pandit, Krzysztof Grzyb, Audun Elnæs Berstad, Åsmund Avdem Fretland, Gunhild Mari Mælandsmo, Anne-Lise Børresen-Dale, Anne Hansen Ree, Bjørn Edwin, Vigdis Nygaard, Kjersti Flatmark
Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to identify molecular characteristics of metastatic disease and evaluate the clinical relevance...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29080924/exploratory-analyses-assessing-the-impact-of-early-tumour-shrinkage-and-depth-of-response-on-survival-outcomes-in-patients-with-ras-wild-type-metastatic-colorectal-cancer-receiving-treatment-in-three-randomised-panitumumab-trials
#5
Julien Taieb, Fernando Rivera, Salvatore Siena, Meinolf Karthaus, Manuel Valladares-Ayerbes, Javier Gallego, Michael Geissler, Reija Koukakis, Gaston Demonty, Marc Peeters
PURPOSE: To report exploratory analyses of early tumour shrinkage (ETS) and depth of response (DpR) in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC), receiving the first-line treatment in three randomised panitumumab trials. METHODS: Data from the PRIME (NCT00364013), PEAK (NCT00819780) and PLANET (NCT00885885) studies were included. Median DpR, the proportion of patients achieving ETS ≥ 20% or ≥ 30% at week 8, and the impact of ETS and DpR (including by category) on outcome were analysed...
October 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29076812/surgical-outcomes-in-patients-with-hepatic-synchronous-and-metachronous-colorectal-metastasis
#6
Maria Laura Cossu, Giorgio Carlo Ginesu, Claudio Francesco Feo, Alessandro Fancellu, Antonio Pinna, Isabel Vargiu, Francesca Addis, Michele Barmina, Giovanni Sotgiu, Alberto Porcu
AIM: To evaluate the impact of several clinical and pathological factors on the outcomes of surgery for hepatic colorectal cancer metastasis. METHODS: Eighty-four liver metastasectomies in 77 consecutive patients with 90 colorectal cancer hepatic metastases were performed in our institution from 2009 to 2014. Surgery was carried out in 75 cases, as two patients were not eligible for surgery. Among them 43 (Group A) were affected by synchronous, and 32 (Group B) by metachronous lesions...
October 25, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29072417/prediction-of-response-to-irinotecan-and-drug-toxicity-based-on-pharmacogenomics-test-a-prospective-case-study-in-advanced-colorectal-cancer
#7
A H Emami, S Sadighi, R Shirkoohi, M A Mohagheghi
Background: FOLFIRI regimen, which is composed of 5-FU, Leucovorin, and Irinotecan, is used in the first-line chemotherapy of metastatic colorectal cancer. Irinotecan life threatening toxicity is partly related to cytotoxic drug metabolite which is primarily inactivated by the UGT1A1 enzyme. The primary aim of the present research was to find the correlation between UGT1A1-genotype and clinical toxicity of irinotecan. Methods: In a prospective study from March 2011 to December 2013, all patients with metastatic colorectal cancer who had been referred to Medical Oncology Department of Iran Cancer Institute were genotyped for UGT1A1*28 before the first cycle of chemotherapy...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071660/impact-of-ras-mutations-in-metastatic-colorectal-cancer-after-potentially-curative-resection-does-site-of-metastases-matter
#8
Guillaume Passot, Bradford J Kim, Olivier Glehen, Reza J Mehran, Scott E Kopetz, Diane Goere, Michael J Overman, Marc Pocard, Frédéric Marchal, Claudius Conrad, Thomas A Aloia, Jean-Nicolas Vauthey, Yun Shin Chun
BACKGROUND: RAS mutation status is an important prognostic factor after resection of liver metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after resection of lung (LuM) and peritoneal (PM) metastases from CRC is unknown. METHODS: Between 2005 and 2014, all consecutive patients with known RAS status who underwent potentially curative resection for LiM, LuM, or PM were evaluated. RESULTS: A total of 720 patients with known RAS status underwent resection of LiM (n = 468), LuM (n = 102), and PM (n = 150)...
October 25, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29063852/local-control-outcomes-using-stereotactic-body-radiation-therapy-for-liver-metastases-from-colorectal-cancer
#9
Ji Hyeon Joo, Jin-Hong Park, Jin Cheon Kim, Chang Sik Yu, Seok-Byung Lim, In Ja Park, Tae Won Kim, Yong Sang Hong, Kyu-Pyo Kim, Sang Min Yoon, Jongmoo Park, Jong Hoon Kim
PURPOSE: To evaluate the effective dose and patterns of recurrence after stereotactic body radiation therapy (SBRT) for hepatic metastases that arise from colorectal cancer. METHODS AND MATERIALS: A cohort of 70 patients with 103 colorectal liver metastases were treated with SBRT at a single institution. The prescribed doses were 45 to 60 Gy in 3 to 4 fractions, but these were modified according to the tolerance of the adjacent normal tissue. To allow for dose comparisons, a biological equivalent dose was calculated...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29061283/liver-resection-for-metastases-not-of-colorectal-neuroendocrine-sarcomatous-or-ovarian-ncnso-origin-a-multicentric-study
#10
Ismail Labgaa, Ksenija Slankamenac, Erik Schadde, Ghalib Jibara, Kutaiba Alshebeeb, Gilles Mentha, Pierre-Alain Clavien, Myron Schwartz
BACKGROUND: Liver resection is a well-established treatment for colorectal, neuroendocrine and sarcomatous metastases but remains ill-defined for metastases from other primary sites. This study aimed to analyze the outcomes of hepatic resection for metastases not of colorectal, neuroendocrine, sarcomatous, or ovarian (NCNSO) origin and to identify predictors of outcome. METHODS: Retrospective analysis of patients undergoing resection for NCNSO metastases in three western centers...
October 7, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29058260/progression-free-survival-in-patients-receiving-chemotherapy-alone-c-or-chemotherapy-with-bevacizumab-cb-for-first-line-treatment-of-kras-mutant-metastatic-colorectal-cancer-in-community-oncology-settings
#11
Arthur C Houts, Sarika Ogale, Yousuf Zafar, Joleen M Hubbard, Sacha Satram-Hoang, Nicolas Sommer, Mark S Walker
PURPOSE: Bevacizumab is a standard first-line (L1) treatment for metastatic colorectal cancer (mCRC) patients regardless of RAS status. This retrospective study examined treatment patterns and outcomes in a community oncology sample of KRAS mutant mCRC patients treated with chemotherapy (C) or C plus bevacizumab (CB) in L1. METHODS: This study used medical records from the Vector Oncology Data Warehouse. Eligible patients were confirmed KRAS mutant mCRC and received L1 C or CB...
October 23, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29057615/systematic-review-of-the-psychometric-properties-of-disease-specific-quality-of-life-questionnaires-for-patients-with-hepatobiliary-or-pancreatic-cancers
#12
REVIEW
Lang Tian, Xiao-Yi Cao
AIM: To systematically review the quality of the psychometric properties of disease-specific quality-of-life questionnaires for patients with hepatobiliary or pancreatic cancers in order to help researchers and clinicians to select the most appropriate health-related quality-of-life (HRQoL) instruments. METHODS: MEDLINE from 1950, CINAHL from 1960, EMBASE from 1980, and PsycINFO from 1967, as well as additional sources were searched. The quality of the psychometric properties of the included instruments was evaluated by using the quality criteria for measurement properties of health status questionnaires...
October 23, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29054396/clinical-outcome-after-biliary-drainage-for-metastatic-colorectal-cancer-survival-analysis-and-prognostic-factors
#13
Floriane Sellier, Erwan Bories, Camille Sibertin-Blanc, Karolina Griffiths, Laetitia Dahan, Marc Giovannini, Jean Gaudart, Jean-Franois Seitz, Rene Laugier, Fabrice Caillol, Philippe Grandval
INTRODUCTION: Biliary obstruction secondary to colorectal cancer liver metastases is associated with a poor prognosis especially when chemotherapy cannot be re-started. The aim of this study was to determine the survival after biliary drainage and the associated prognostic factors. METHODS: Patients from two French centers were included retrospectively after first biliary endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography drainage for biliary obstruction secondary to liver metastases of colorectal cancer, occurring during chemotherapy...
September 21, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29050339/aberrant-expression-of-oatp1b3-in-colorectal-cancer-liver-metastases-and-its-clinical-implication-on-gadoxetic-acid-enhanced-mri
#14
Seung Hyun Park, Honsoul Kim, Eun Kyung Kim, Hogeun Kim, Dong Kyu Choi, Yong Eun Chung, Myeong-Jin Kim, Jin-Young Choi
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29034693/role-of-18-f-fdg-pet-ct-vs-ct-scan-in-patients-with-pulmonary-metastases-previously-operated-on-for-colorectal-liver-metastases
#15
Victor Lopez-Lopez, Ricardo Robles, Roberto Brusadin, Asuncion López Conesa, Juan Torres, Domingo Perez Flores, Jose Luis Navarro, Pedro Jose Gil, Pascual Parrilla
OBJECTIVE: There is currently no conclusive scientific evidence available regarding the role of the (18)F-FDG PET/CT for detecting pulmonary metastases from colorectal cancer (PMCRC) in patients operated on for colorectal liver metastases (CRLM). In the follow up of patients who underwent surgery for CRLM, we compare CT-scan and (18)F-FDG PET/CT in patients with PMCRC. METHODS: We designed the study prospectively performing an (18)F-FDG PET/CT on all patients operated on for CRLM where the CT-scan detected PMCRC during the follow up...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29029986/radiofrequency-ablation-for-colorectal-cancer-liver-metastases-initially-greater-than-25%C3%A2-mm-but-downsized-by-neo-adjuvant-chemotherapy-is-associated-with-increased-rate-of-local-tumor-progression
#16
Léonor Benhaim, Mostafa El Hajjam, Robert Malafosse, Jacques Sellier, Catherine Julie, Alain Beauchet, Bernard Nordlinger, Frédérique Peschaud
BACKGROUND: Radiofrequency ablation (RFA) is a valid treatment for liver metastases from colorectal cancer (CRLM) smaller than 25 mm and unsuitable for surgical resection. Tumor size is predictive for local tumor progression (LTP). The aim of this study was to evaluate whether RFA is indicated for lesions >25 mm at presentation but <25 mm after chemotherapy. METHOD: Patients who underwent RFA for CRLM after chemotherapy (January 2004-December 2012) were reviewed...
October 10, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29026950/the-prognostic-value-of-18-f-fdg-pet-ct-prior-to-liver-transplantation-for-nonresectable-colorectal-liver-metastases
#17
Harald Grut, Svein Dueland, Pål Dag Line, Mona Elisabeth Revheim
PURPOSE: The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29019334/brain-metastasis-from-colorectal-adenocarcinoma-a-case-report
#18
Jaroslav Nemec, Abdulsalam Alnajjar, Jasem Albarrak, Shaban A, Mariam Al Otaibi, Asit Mohanty
Colorectal cancer (CRC) is the third leading cause of cancer death in the Western world, accounting for approximately 140,000 new cases and more than 51,000 deaths in 2010 in the United States. In Kuwait, CRC is the first most-diagnosed neoplasm among males and overall, the second leading cause of death from cancer. The 5-year survival rate in 2002-2004 was 61% for men and 62% for women. Even after complete resection of the colorectal tumor, distant metastases have been noted to develop in 10%-15% of patients...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28985870/polymeric-micelles-loaded-with-1-2-diaminocyclohexane-platinum-ii-against-colorectal-cancer
#19
Takako Nirei, Soichiro Ishihara, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hioaki Nozawa, Toshiaki Watanabe
BACKGROUND: We investigated the potential of nanomedicine in loading the oxaliplatin parent complex (1,2-diaminocyclohexane)platinum(II)-loaded polymeric micelles (DACHPt/m) against multiple liver metastases from colon cancer in a mouse model. MATERIALS AND METHODS: The efficacy of DACHPt/m or oxaliplatin (on days 14 and 21 after inoculation of tumor cells) was evaluated in a mouse model of liver metastasis for murine colon adenocarcinoma C26 cells. In vivo antitumor effects were evaluated by recording the number of liver metastases and weights of metastatic livers after treatment (day 28)...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28982110/international-consensus-guidelines-for-scoring-the-histopathological-growth-patterns-of-liver-metastasis
#20
Pieter-Jan van Dam, Eric P van der Stok, Laure-Anne Teuwen, Gert G Van den Eynden, Martin Illemann, Sophia Frentzas, Ali W Majeed, Rikke L Eefsen, Robert R J Coebergh van den Braak, Anthoula Lazaris, Maria Celia Fernandez, Boris Galjart, Ole Didrik Laerum, Roni Rayes, Dirk J Grünhagen, Michelle Van de Paer, Yves Sucaet, Hardeep Singh Mudhar, Michael Schvimer, Hanna Nyström, Mark Kockx, Nigel C Bird, Fernando Vidal-Vanaclocha, Peter Metrakos, Eve Simoneau, Cornelis Verhoef, Luc Y Dirix, Steven Van Laere, Zu-Hua Gao, Pnina Brodt, Andrew R Reynolds, Peter B Vermeulen
BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs. METHODS: Guidelines for defining the HGPs were established by a large international team...
November 7, 2017: British Journal of Cancer
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