Felicia Li-Sher Tan, Aikseng Ooi, Dachuan Huang, Jing Chii Wong, Chao-Nan Qian, Cora Chao, London Ooi, Yu-Meng Tan, Alexander Chung, Peng-Chung Cheow, Zhongfa Zhang, David Petillo, Ximing J Yang, Bin Tean Teh
Cholangiocarcinoma (CC) and hepatocellularcarcinoma (HCC) are two main forms of liver malignancies, which exhibit differences in drug response and prognosis. Immunohistotochemical staining for cytokeratin markers has been used to some success in the differential diagnosis of CC from HCC. However, there remains a need for additional markers for increased sensitivity and specificity of diagnosis. In this study, we have identified a p38 MAP kinase, p38delta (also known as MAPK13 or SAPK4) as a protein that is upregulated in CC relative to HCC and to normal biliary tract tissues...
May 15, 2010: International Journal of Cancer. Journal International du Cancer