Liang Cheng, Jiatao Liu, Qingqing Liu, Yu Liu, Lulu Fan, Fang Wang, Hanqing Yu, Yuhuan Li, Lijia Bu, Xiaoqiu Li, Wei Wei, Hua Wang, Guoping Sun
Immunosuppression is a significant factor in the progression of tumor invasion and metastasis. Melatonin, a well-known hormone, has certain cytotoxic and immune regulatory effects to inhibit tumor function. Exosomes are small membrane vesicles released by many kinds of cells, which contain different macromolecules, such as mRNAs and microRNAs (miRNAs), and proteins that can mediate communications between cells. Tumor-derived exosomes may cause immunosuppression, however, it is unknown whether melatonin can attenuate an immunosuppressive status by altering the function of tumor-derived exosomes...
2017: International Journal of Biological Sciences