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Hepatocellularcarcinoma

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https://www.readbyqxmd.com/read/27381607/dietary-protective-effects-against-hepatocellular-carcinoma-development-in-mdr2-knockout-mice
#1
Maria Pia Gentileschi, Claudia Lattanzio, Francesco Menicagli, Bruno Vincenzi, Giovanni Cigliana, Alfonso Baldi, Giovanni Blandino, Paola Muti, Maurizio Fanciulli, Enrico P Spugnini
BACKGROUND/AIM: The Mdr2(-/-) mouse develops early chronic cholestatic hepatitis and hepatocellularcarcinoma (HCC) when adult. We tested the effects of a restricted-calorie diet on HCC development in Mdr2(-/-) mice. MATERIALS AND METHODS: Mdr2(-/-) mice (n=40, divided into two groups of 20 mice each) were randomized to receive ad libitum diet or restricted-calorie diet. Two mice from each group were sacrificed at 3 and 6 months, and liver tissue samples were removed for analysis...
July 2016: In Vivo
https://www.readbyqxmd.com/read/26322172/sgf29-and-sry-pathway-in-hepatocarcinogenesis
#2
REVIEW
Nobuya Kurabe, Shigekazu Murakami, Fumio Tashiro
Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas (SAGA) complex component, SAGA-associated factor 29 (SGF29), in regulating the c-Myc overexpression. Here, we discuss the molecular nature of SFG29 in SPT3-TAF9-GCN5-acetyltransferase complex, a counterpart of yeast SAGA complex, and the mechanism through which the elevated SGF29 expression contribute to oncogenic potential of c-Myc in hepatocellularcarcinoma (HCC)...
August 26, 2015: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26155416/t-cell-receptor-therapy-in-hbv-related-hepatocellularcarcinoma
#3
Antonio Bertoletti, Maurizia Brunetto, Mala K Maini, Ferruccio Bonino, Waseem Qasim, Hans Stauss
Adoptive transfer of lymphocytes expressing engineered T cell receptors (TCR) is a promising option for cancer treatment and could include hepatocellularcarcinoma (HCC), where therapeutic options are limited. We have recently investigated whether hepatitis B viral antigens can act as a HCC-specific antigen and thus be targeted by adoptively transferred HBV-specific TCR redirected T cells.
June 2015: Oncoimmunology
https://www.readbyqxmd.com/read/24586698/a-novel-predictive-equation-for-potential-diagnosis-of-cholangiocarcinoma
#4
Ratthaphol Kraiklang, Chawalit Pairojkul, Narong Khuntikeo, Kanokwan Imtawil, Sopit Wongkham, Chaisiri Wongkham
Cholangiocarcinoma (CCA) is the second most common-primary liver cancer. The difficulties in diagnosis limit successful treatment of CCA. At present, histological investigation is the standard diagnosis for CCA. However, there are some poor-defined tumor tissues which cannot be definitively diagnosed by general histopathology. As molecular signatures can define molecular phenotypes related to diagnosis, prognosis, or treatment outcome, and CCA is the second most common cancer found after hepatocellularcarcinoma (HCC), the aim of this study was to develop a predictive model which differentiates CCA from HCC and normal liver tissues...
2014: PloS One
https://www.readbyqxmd.com/read/23277276/proteomics-in-hepg2-hepatocarcinoma-cells-with-stably-silenced-expression-of-prdx1
#5
Patricia Aguilar-Melero, María-José Prieto-Álamo, Juan Jurado, Arne Holmgren, Carmen Pueyo
Peroxiredoxin 1 (PRDX1) is a member of the peroxiredoxin family. Aberrant expression of PRDX1 has been described in various cancers. We investigated the significance of this up-regulation in non-challenged hepatocellularcarcinoma (HCC) cells by establishing a HepG2 cell line stably expressing a Prdx1 shRNA. Prdx1 silencing reversed, at least partially, the tumoural phenotype of HepG2 cells, resulting in morphological changes, delayed cell growth, down-regulation of transcripts for AFP, osteopontin and β-catenin and decreased γ-glutamyl transpeptidase activity, and oppositely up-regulation of transcripts for E-cadherin and proapoptotic proteins (BAX, CASP3) and increased alkaline phosphatase and CASP3 activities...
February 21, 2013: Journal of Proteomics
https://www.readbyqxmd.com/read/23276044/-chemoembolization-dem-tace-in-hepatocellularcarcinoma-report-of-a-case-and-review-of-treatment-standards-in-advanced-stage-disease
#6
Magdalena Jarzabek, Tomasz Jargiełło, Krzysztof Pyra, Anna Budzyńska, Michał Przyszlak, Malgorzata Szczerbo-Trojanowska
Despite, new diagnostic and treatment techniques, the wide majority of patients are still diagnosed too late and only from 5% to 10% of patients are qualified for tumour surgical resection. Up to date, treatment for advanced, inoperable liver tumors includes systemic chemotherapy, sorafenib therapy and selective, local arterial injection of chemotherapeutic drug into tumour vessels with simultaneous vessel closure - transarterial chemoembolisation (TACE). Beceause of recent development of palliative treatment techniques, the treatment guidelines are changed, especially in advanced stage disease with HCC...
2012: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/20527273/combined-assessment-of-tgf-beta-1-and-alpha-fetoprotein-values-improves-specificity-in-the-diagnosis-of-hepatocellular-carcinoma-and-other-chronic-liver-diseases-in-malaysia
#7
M Y Yasmin Anum, M L Looi, A H Nor Aini, I Merican, A Wahidah, A H Mohd Radzi, A Nor Azizah, N H Othman
Transforming growth factor beta-1 (TGF-beta-1) is a multifunctional cytokine involved in the regulation of growth and differentiation of both normal and transformed cells. The main aim of this study was to determine whether TGF-beta-1 or alpha fetoprotein (AFP) or the combination of the two is a better indicator for hepatocellularcarcinoma (HCC). Serum TGF-beta-1 and AFP were measured by ELISA in 40 healthy subjects, 23 patients with hepatocellular carcinoma (HCC), 70 patients with hepatitis B, 26 patients with hepatitis C and 16 patients with liver cirrhosis (LC)...
September 2009: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/19816939/p38delta-mapk13-as-a-diagnostic-marker-for-cholangiocarcinoma-and-its-involvement-in-cell-motility-and-invasion
#8
Felicia Li-Sher Tan, Aikseng Ooi, Dachuan Huang, Jing Chii Wong, Chao-Nan Qian, Cora Chao, London Ooi, Yu-Meng Tan, Alexander Chung, Peng-Chung Cheow, Zhongfa Zhang, David Petillo, Ximing J Yang, Bin Tean Teh
Cholangiocarcinoma (CC) and hepatocellularcarcinoma (HCC) are two main forms of liver malignancies, which exhibit differences in drug response and prognosis. Immunohistotochemical staining for cytokeratin markers has been used to some success in the differential diagnosis of CC from HCC. However, there remains a need for additional markers for increased sensitivity and specificity of diagnosis. In this study, we have identified a p38 MAP kinase, p38delta (also known as MAPK13 or SAPK4) as a protein that is upregulated in CC relative to HCC and to normal biliary tract tissues...
May 15, 2010: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/17127296/oncogenesis-and-transforming-viruses-the-hepatitis-b-virus-and-hepatocellularcarcinoma-the-etiopathogenic-link
#9
REVIEW
Alvin T C Lee, Caroline G L Lee
Hepatocellular carcinoma (HCC) is one of the world's leading fatal malignancies. Chronic infection with the hepatitis B virus (HBV) has been implicated with the development of HCC. For the past three decades, intensive research has focused on the role of HBV in hepatocarcinogenesis. Various HBV-associated models have emerged, but increasing evidence points to two major HBV-specific mechanisms that contribute to the development of HCC. The first is the integration of the viral genome into the host chromosome causing cis-effects, resulting in loss of tumor suppressor gene functions, and/or activation of tumor-promoting genes...
2007: Frontiers in Bioscience: a Journal and Virtual Library
https://www.readbyqxmd.com/read/16931769/mobilization-of-bone-marrow-derived-hematopoietic-and-endothelial-stem-cells-after-orthotopic-liver-transplantation-and-liver-resection
#10
Roberto M Lemoli, Lucia Catani, Simona Talarico, Elisabetta Loggi, Annagiulia Gramenzi, Umberto Baccarani, Miriam Fogli, Gian Luca Grazi, Michela Aluigi, Giulia Marzocchi, Mauro Bernardi, Antonio Pinna, Fabrizio Bresadola, Michele Baccarani, Pietro Andreone
In animals, the bone marrow (BM) is a source of liver-repopulating cells with therapeutic potential in case of tissue damage. However, the early response of human BM-derived stem cells (SC) to liver injury is still unknown. Here, we studied 24 patients undergoing orthotopic liver transplantation (OLT) for end-stage liver disease or hepatocellularcarcinoma, and 13 patients submitted to liver resection. The concentration of circulating BM-derived SC was determined by phenotypic analysis and clonogenic assays...
December 2006: Stem Cells
https://www.readbyqxmd.com/read/15631087/-detection-of-differentially-expressed-genes-in-hepatocellularcarcinoma-cells-smmc-7721-treated-with-typhonium-giganteum-extract-by-mrna-differential-display
#11
Shun-qi Wang, Hong Ni, Hua Cheng, Guang-liang Wang, Tong-shun Wang, Li Chen
OBJECTIVE: To screen and identify the differentially expressed genes in hepatocellular carcinoma cells SMMC-7721 responsing to the aqueous extract from dried powdered rhizomes of Typhonium giganteum (AEoTGE). METHOD: The response of hepatocellular carcinoma cells SMMC-7721 to AEoTGE was explored with the technique of mRNA differential display. RESULT: After hepatocarcinoma cells SMMC-7721 were treated by AEoTGE for 36 hours, 1 gene expression was upgrade and 1 gene expression was downgrade induced by AEoTGE...
October 2004: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/14708468/-prevalence-of-hepatic-involvement-alcoholism-hepatis-b-c-and-hiv-in-patients-with-background-history-of-drug-use
#12
D R Cocozella, M M Albuquerque, S Borzi, M Barrio, V Dascenzo, J C Santecchia, J González, R E Adrover, C Meneses, E Fraquelli, J O Curciarello
UNLABELLED: Drug addicts frequently have liver diseases for different reasons: alcohol abuse, the drugs themselves, but more often hepatitis B and C infections. AIDS is common in this population as well and could also affect the liver directly or in the form of hepatocellular or biliary damage. We conducted this study to determine the prevalence of liver diseases, alcoholism, hepatitis B and C infections, and HIV positivity in this population. We studied a cohort of 137 persons, all with a history of drug abuse, and investigated the quantity of alcohol intake, the kind of drug used, and he routes of drug administration...
2003: Acta Gastroenterologica Latinoamericana
https://www.readbyqxmd.com/read/14537130/quantitative-measurement-of-regional-blood-flow-in-hepatic-focal-nodular-hyperplasia-findings-on-positron-emission-tomography
#13
Satoshi Kunishima, Toshimori Koh, Kenichirou Fukuda, Hiroki Taniguchi
The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 water (dynamic state). The steady state PET images revealed higher radioactivity concentration in the lateral lobe than in the surrounding normal liver parenchyma. Regional and total blood flow in the region of FNH, as determined by the dynamic state method, was 292...
May 2002: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/12595157/inhibition-of-nitrosodiethylamine-induced-hepatocarcinogenesis-by-dietary-turmeric-in-rats
#14
R Thapliyal, K N Naresh, K V K Rao, G B Maru
Turmeric, widely used in food and medicine has been shown to prevent benzo(a)pyrene [B(a)P] or dimethylbenz(a)anthracene (DMBA)-induced forestomach, skin and mammary tumors in mice and/or rats. In this study we examine the modulatory effects of turmeric on nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in rats. Female Wistar rats were administered NDEA (200 ppm) through drinking water (5 days per week) for 4 weeks. Control and/or NDEA-treated rats received 0, 0.2, 1.0 or 5.0% turmeric diet (w/w) either before (2 weeks), during (4 weeks) and after NDEA exposure (10 weeks) or starting from 24 h after NDEA exposure for 10 weeks...
March 20, 2003: Toxicology Letters
https://www.readbyqxmd.com/read/12526348/-investigation-of-hgv-infection-in-various-populations-in-guangxi
#15
H Ru, X Wen, W Liang
In order to understand the situation of HGV infection in various populations in Liuzhou prefecture of Guangxi, Zhuangzu Autonomous Region, and also to compare the HGV, HBV, HCV infections between intravenous drug abusers and healthy persons (those for physical examination, the same below), the anti-HGV, -HCV and HBVM (HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) were detected by ELA and, besides, tested further the 20 anti-HGV seropositive cases for HGV-RNA by RT-nPCR. The results showed that in the populations tested, the HGV seropositive rate was 9...
December 1998: Chinese Journal of Experimental and Clinical Virology
https://www.readbyqxmd.com/read/12019758/cancare-a-herbal-formulation-inhibits-chemically-induced-tumours-in-experimental-animals
#16
N V Rajeshkumar, R Kuttan
Cancer chemopreventive potential of Cancare, a multi-herbal formulation on chemically induced tumours was studied by N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in rats and 20-methylcholanthrene (20-MC) induced sarcoma development in mice. Oral administration of Cancare was found to inhibit the liver tumour development induced by N-nitrosodiethylamine. Animals administered with NDEA had visible liver tumours by the end of 30th weeks and the liver weight was raised to 6.1 +/- 1.4 g/ 100 g body wt...
July 2001: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/10693685/extended-left-hepatectomy-left-hepatic-trisegmentectomy-in-childhood
#17
R D Glick, E P Nadler, L H Blumgart, M P La Quaglia
BACKGROUND/PURPOSE: Extended left hepatectomy, also referred to as left hepatic trisegmentectomy, in which segments II, III, IV, V, and VIII are excised, is rarely performed in children. Experience with 7 such resections is reported to describe the anatomy, technique, indications, and outcomes of the operation. METHODS: The medical records of all pediatric patients treated at our institution over the last 15 years who underwent extended left hepatectomy were reviewed...
February 2000: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/9151922/zinostatin-stimalamer-transcatheter-arterial-embolization-for-hepatocellular-carcinoma-a-comparison-with-lipiodol-transcatheter-arterial-embolization
#18
COMPARATIVE STUDY
N Hirashima, K Sakakibara, I Itazu, T Hirai, A Nemoto, H Matsuura, K Kumada, O Nojiri, H Kano
Twenty patients with unresectable hepatocellular carcinoma were treated by zinostatin stimalamer-transcatheter arterial embolization (SMANCS-TAE). After administration of SMANCS, a superselective catheterization technique was used to inject gelatin sponge particles into the artery or artery branch supplying the cancer-bearing segment. We compared the results of SMANCS-TAE with Lipiodol (Yamanouchi, Tokyo, Japan)-TAE performed during the same period. In 18 of 20 patients (90%), a tumor necrosis rate of 100% (grade 4) was obtained after one or two courses of SMANCS-TAE...
April 1997: Seminars in Oncology
https://www.readbyqxmd.com/read/3550607/-importance-of-locoregional-chemotherapy-by-anthracyclines
#19
P Rougier
With loco-regional chemotherapy high local concentration of antineoplastic products can be achieved without systemic toxicity. However local toxicity and technical problems are frequent and limit its use. Intra arterial chemotherapy (IAC) is interesting when the drugs used have a high total body clearance. One of the best indication of IAC is the intra-hepatic chemotherapy with anthracyclin for hepatocellularcarcinoma (40-60% objective response) and metastatic carcinoid. Among other IAC the IA limbs perfusions for soft tissue sarcoma have given interesting results...
January 1987: Pathologie-biologie
https://www.readbyqxmd.com/read/3024010/rearrangement-and-enhanced-expression-of-c-myc-in-hepatocellular-carcinoma-of-hepatitis-virus-infected-woodchucks
#20
T Möröy, A Marchio, J Etiemble, C Trépo, P Tiollais, M A Buendia
Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ranging from 2.0 kilobases (kb) to 5.6 kb, as well as in the level of c-myc gene expression, 5-50-fold higher than in adjacent liver tissues, were observed among the three HCC. Rearrangements of the c-myc locus were either upstream of the gene or within the first intron...
November 20, 1986: Nature
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