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https://www.readbyqxmd.com/read/29587674/androgen-receptor-in-advanced-breast-cancer-is-it-useful-to-predict-the-efficacy-of-anti-estrogen-therapy
#1
Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori, Sara Bravaccini
BACKGROUND: Androgen receptor (AR) is widely expressed in breast cancer (BC) but its role in estrogen receptor (ER)-positive tumors is still controversial. The AR/ER ratio has been reported to impact prognosis and response to antiestrogen endocrine therapy (ET). METHODS: We assessed whether AR in primary tumors and/or matched metastases is a predictor of efficacy of first-line ET in advanced BC. Patients who had received first-line ET (2002-2011) were recruited, while those given concomitant chemotherapy or trastuzumab or pretreated with > 2 lines of chemotherapy were excluded...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29464065/the-presence-of-pd-1-positive-tumor-infiltrating-lymphocytes-in-triple-negative-breast-cancers-is-associated-with-a-favorable-outcome-of-disease
#2
Gero Brockhoff, Stephan Seitz, Florian Weber, Florian Zeman, Monika Klinkhammer-Schalke, Olaf Ortmann, Anja Kathrin Wege
Triple negative breast cancer patients have a poor course of disease not least because of limited treatment options however immunotherapy by targeting the PD-1/PD-L1 checkpoint system is a promising strategy to improve the outcome. Here we systematically investigated the expression of PD-1 on tumor infiltrating lymphocytes and PD-L1 on both tumor and infiltrated immune cells. Moreover, the PD-L1 gene status in tumor cells was assessed. 103 tissue microarray samples derived from triple negative breast cancer specimens were immunohistochemically stained against PD-1 and PD-L1...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29444670/breast-cancer-in-ethiopia-evidence-for-geographic-difference-in-the-distribution-of-molecular-subtypes-in-africa
#3
Endale Hadgu, Daniel Seifu, Wondemagegnhu Tigneh, Yonas Bokretsion, Abebe Bekele, Markos Abebe, Thomas Sollie, Sofia D Merajver, Christina Karlsson, Mats G Karlsson
BACKGROUND: Breast cancer is a heterogeneous disease with several morphological and molecular subtypes. Widely accepted molecular classification system uses assessment of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker Ki67. Few studies have been conducted on the incidence and molecular types of breast cancer in Sub-Saharan Africa. Previous studies mainly from Western and Central Africa, showed breast cancer to occur at younger ages and to present with aggressive features, such as high-grade, advanced stage and triple-negative phenotype (negative for ER, PR and HER2)...
February 14, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29416803/clinical-significance-of-detecting-csf-derived-tumor-cells-in-breast-cancer-patients-with-leptomeningeal-metastasis
#4
Xuelu Li, Yuan Zhang, Jinlei Ding, Min Wang, Na Li, Hui Yang, Kainan Wang, Dandan Wang, Peter Ping Lin, Man Li, Zuowei Zhao, Pixu Liu
Despite marked advances in breast cancer therapy, breast cancer-associated leptomeningeal metastasis (LM), a particularly aggressive syndrome with multifocal seeding of the leptomeninges by tumor cells, still carries an abysmal prognosis. A major problem with breast cancer LM surveillance is the lack of an effective and sensitive means to track dynamic changes of the disease. Cytology detection of cerebrospinal fluid (CSF) is considered the gold standard for LM diagnosis but has a high false-negative rate with a limited sensitivity...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29372072/the-market-trend-analysis-and-prospects-of-cancer-molecular-diagnostics-kits
#5
Ju Hwan Seo, Joon Woo Lee, Daemyeong Cho
Background: The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women's health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29364207/protocol-for-her2-fish-using-a-non-cross-linking-formalin-free-tissue-fixative-to-combine-advantages-of-cryo-preservation-and-formalin-fixation
#6
Martina Loibner, Lisa Oberauner-Wappis, Christian Viertler, Daniel Groelz, Kurt Zatloukal
Morphologic assessment of formalin-fixed, paraffin-embedded (FFPE) tissue samples has been the gold standard for cancer diagnostics for decades due to its excellent preservation of morphology. Personalized medicine increasingly provides individually adapted and targeted therapies for characterized individual diseases enabled by combined morphological and molecular analytical technologies and diagnostics. Performance of morphologic and molecular assays from the same FFPE specimen is challenging because of the negative impact of formalin due to chemical modification and cross-linking of nucleic acids and proteins...
December 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29357745/targeting-her2-in-nuclear-medicine-for-imaging-and-therapy
#7
Adriana V F Massicano, Bernadette V Marquez-Nostra, Suzanne E Lapi
Since its discovery, the human epidermal growth factor 2 (HER2) has been extensively studied. Presently, there are 2 standard diagnostic techniques to assess HER2 status in biopsies: immunohistochemistry and fluorescence in situ hybridization. While these techniques have played an important role in the treatment of patients with HER2-positive cancer, they both require invasive biopsies for analysis. Moreover, the expression of HER2 is heterogeneous in breast cancer and can change over the course of the disease...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29284719/cross-sectional-analyses-of-participation-in-cancer-screening-and-use-of-hormone-replacement-therapy-and-medications-in-meat-eaters-and-vegetarians-the-epic-oxford-study
#8
Tammy Y N Tong, Paul N Appleby, Kathryn E Bradbury, Timothy J Key
OBJECTIVES: To examine differences in health-related behaviours such as screening or testing for cancer, use of hormone replacement therapy (HRT) and use of other medications in different diet groups. DESIGN: We studied 31 260 participants across four diet groups (18 155 meat eaters, 5012 fish eaters, 7179 vegetarians, 914 vegans) in the UK EPIC-Oxford cohort. Information was collected in 5-year (around 2000-2003) or 10-year (around 2007) follow-up questionnaires regarding participation in breast screening, cervical screening, prostate-specific antigen (PSA) testing, use of HRT and use of medications for the past 4 weeks...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29251639/mammary-analog-secretory-carcinoma-with-etv6-rearrangement-arising-in-the-conjunctiva-and-eyelid
#9
Yongyang Bao, Jiang Li, Yanbo Zhu
Mammary analog secretory carcinoma (MASC) of salivary gland is a recently described neoplasm that morphologically and immunohistochemically resembles secretory carcinoma of the breast. Genetically, both of them harbor ETV-6-NTRK-3 fusion rearrangement. One case of primary MASCs arising from the eyelid is reported. The patient was a 52-year-old man. Microscopically, the tumor exhibited nodular aggregation of solid, tubular, and microcystic/macrocystic structures. Characteristic "colloid-like" eosinophilic secretory material was present within intraluminal spaces...
November 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29228597/diversity-index-as-a-novel-prognostic-factor-in-breast-cancer
#10
Yul Ri Chung, Hyun Jeong Kim, Young A Kim, Mee Soo Chang, Ki-Tae Hwang, So Yeon Park
Intratumoral genetic heterogeneity leads to tumor progression and therapeutic resistance. However, due to the difficulty associated with its assessment, the use of this heterogeneity as a prognostic or predictive marker remains limited. To investigate the significance of the Shannon diversity index of gene copy number variation as a tool for measuring genetic heterogeneity in breast cancer, we performed fluorescence in situ hybridization of c-MYC in two sets of invasive breast cancer samples and correlated the Shannon index of c -MYC copy number variation with clinicopathologic features and patient survival...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212167/a-nomogram-to-predict-her2-status-in-breast-cancer-patients-with-her2-borderline-disease-as-determined-via-immunohistochemistry
#11
Qianqian Guo, Kai Chen, Xiaojie Lin, Yi Su, Rui Xu, Yan Dai, Chang Qiu, Xue Song, Siying Mao, Qianjun Chen
This study aimed to develop a nomogram to predict fluorescence in situ hybridization (FISH) assay results for HER2-borderline breast cancer as determined via immunohistochemistry (IHC) among patients in China. We reviewed a database of breast cancer patients diagnosed between January 2007 and April 2013 at our institutions. We used logistic regression to develop a nomogram and we used receiver operating characteristic curve analysis and calibration plots to validate our nomogram. In total, 1138, 301 and 344 patients had IHC-determined HER2-negative, HER2-borderline and HER2-positive disease, respectively...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207553/determination-of-the-relative-efficacy-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-for-anti-cancer-effects-in-human-breast-cancer-models
#12
REVIEW
Laura VanderSluis, Vera C Mazurak, Sambasivarao Damaraju, Catherine J Field
Epidemiological studies have associated high fish oil consumption with decreased risk of breast cancer (BC). n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish and fish oils exert anti-cancer effects. However, few studies have examined the relative efficacy of EPA and DHA alone and in mixtures on BC subtypes. This was the objective of the present review, as this research is a necessity for the translation of findings to human health and disease...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29181861/aneuploidy-tp53-mutation-and-amplification-of-myc-correlate-with-increased-intratumor-heterogeneity-and-poor-prognosis-of-breast-cancer-patients
#13
Johanna Oltmann, Kerstin Heselmeyer-Haddad, Leanora S Hernandez, Rüdiger Meyer, Irianna Torres, Yue Hu, Natalie Doberstein, J Keith Killian, David Petersen, Yuelin Jack Zhu, Daniel C Edelman, Paul S Meltzer, Russell Schwartz, E Michael Gertz, Alejandro A Schäffer, Gert Auer, Jens K Habermann, Thomas Ried
The clinical course of breast cancer varies from one patient to another. Currently, the choice of therapy relies on clinical parameters and histological and molecular tumor features. Alas, these markers are informative in only a subset of patients. Therefore, additional predictors of disease outcome would be valuable for treatment stratification. Extensive studies showed that the degree of variation of the nuclear DNA content, i.e., aneuploidy, determines prognosis. Our aim was to further elucidate the molecular basis of aneuploidy...
April 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29181099/breast-cancers-with-egfr-and-her2-co-amplification-favor-distant-metastasis-and-poor-clinical-outcome
#14
Peng Guo, Tianjie Pu, Shinan Chen, Yan Qiu, Xiaorong Zhong, Hong Zheng, Lina Chen, Hong Bu, Feng Ye
ErbB signaling serves essential roles in invasive ductal carcinoma (IDC). The aim of the present study was to assess gene amplification in ErbB family members in IDC with clinical implications. Quantitative polymerase chain reaction and fluorescence in situ hybridization were performed on formalin-fixed paraffin-embedded tumor samples for gene amplification detection. The clinical and histopathological characteristics, as well as the prognostic significance, were analyzed. Among the 119 IDC patients evaluated, epidermal growth factor receptor [ EGFR ; also known as human epidermal growth factor receptor (HER)1], HER2 , HER3 and HER4 gene amplification was observed in 30 (25...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29159791/determining-personalized-treatment-by-gene-expression-profiling-in-metastatic-breast-carcinoma-patients-a-pilot-study
#15
M Sureda, J Rebollo, E Mª Martínez-Navarro, F J Fernández-Morejón, J Farré, V Muñoz, P Bretcha-Boix, M Duarte, R G Manzano, A Crespo, M Del Carmen Redal, B Valenzuela, A Brugarolas
PURPOSE: The present study evaluates the massive study of gene expression in metastatic breast carcinoma (MBC) patients using microarray gene expression profiling (MAGE) complemented with conventional sequencing, immunohistochemistry (IHC) and fluorescent "in situ" hybridization (FISH), seeking to optimize the treatment in a subset of heavily pretreated patients and with limited life expectancy. PATIENTS, MATERIAL AND METHODS: MBC patients in hormone therapy progression with survival expectancy of at least 3 months (m) have been included...
November 20, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29142051/improved-detection-of-her2-by-a-quasi-targeted-proteomics-approach-using-aptamer-peptide-probe-and-liquid-chromatography-tandem-mass-spectrometry
#16
Weixian Zhou, Feifei Xu, Danni Li, Yun Chen
BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive type of the disease. To date, much evidence has indicated that accurate HER2 status detection is crucial for prognosis and treatment strategy selection. Thus, bioanalytical techniques for early and accurate detection of HER2 have the potential to improve patient care. Currently, the widely used immunohistochemical staining normally has problems with reproducibility and lack of standardization, resulting in poor concordance between laboratories...
November 15, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29140993/prognostic-significance-of-cyclin-d1-protein-expression-and-gene-amplification-in-invasive-breast-carcinoma
#17
Angela B Ortiz, Diego Garcia, Yolanda Vicente, Magda Palka, Carmen Bellas, Paloma Martin
The oncogenic capacity of cyclin D1 has long been established in breast cancer. CCND1 amplification has been identified in a subset of patients with poor prognosis, but there are conflicting data regarding the predictive value of cyclin D1 protein overexpression. This study was designed to analyze the expression of cyclin D1 and its correlation with CCND1 amplification and their prognostic implications in invasive breast cancer. By using the tissue microarray technique, we performed an immunohistochemical study of ER, PR, HER2, p53, cyclin D1, Ki67 and p16 in 179 invasive breast carcinoma cases...
2017: PloS One
https://www.readbyqxmd.com/read/28929359/immunohistochemical-versus-molecular-blueprint-and-mammaprint-subtyping-of-breast-carcinoma-outcome-results-from-the-eortc-10041-big-3-04-mindact-trial
#18
G Viale, F A de Snoo, L Slaets, J Bogaerts, L van 't Veer, E J Rutgers, M J Piccart-Gebhart, L Stork-Sloots, A Glas, L Russo, P Dell'Orto, K Tryfonidis, S Litière, F Cardoso
PURPOSE: This study compares immunohistochemical (IHC) versus molecular subtyping (BluePrint and MammaPrint) in the population of patients enrolled in MINDACT and outcome based on molecular subtyping (MS) versus surrogate pathological subtyping (PS) as defined by the 2013 St. Gallen guidelines. METHODS: MS classified patients in the following subtypes: Luminal A, Luminal B, HER-2-, and Basal-type. IHC/FISH for pathological subtyping (ER, PgR, HER-2, and Ki67) was centrally assessed in the European Institute of Oncology (n = 5806)...
January 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28921714/fetal-microchimerism-in-human-brain-tumors
#19
Lauren Broestl, Joshua B Rubin, Sonika Dahiya
Sex differences in cancer incidence and survival, including central nervous system tumors, are well documented. Multiple mechanisms contribute to sex differences in health and disease. Recently, the presence of fetal-in-maternal microchimeric cells has been shown to have prognostic significance in breast and colorectal cancers. The frequency and potential role of these cells has not been investigated in brain tumors. We therefore selected two common primary adult brain tumors for this purpose: meningioma, which is sex hormone responsive and has a higher incidence in women, and glioblastoma, which is sex hormone independent and occurs more commonly in men...
September 18, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28889723/expression-of-c-myc-and-%C3%AE-catenin-and-their-correlation-in-triple-negative-breast-cancer
#20
Jiankui Wang, Mei Li, Dedian Chen, Jianyun Nie, Yan Xi, Xiaojuan Yang, Yun Chen, Zhuanqing Yang
BACKGROUND: The present study was planned to study the expression of C-myc and β-catenin in triple negative breast cancer (TNBC) tissue. Furthermore, their relations to clinical features of the tumor and the survival prognosis were also studied. Additionally, correlation was evaluated between the expression of C-myc and β-catenin to provide the theoretical basis for the targeted therapy of TNBC. METHODS: Sixty cases of patients diagnosed with TNBC for the first time were selected for the study...
December 2017: Minerva Medica
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