Gregory D Gromowski, Camila Macedo Cincotta, Sandra Mayer, Jocelyn King, Isabella Swafford, Michael K McCracken, Dante Coleman, Jennifer Enoch, Casey Storme, Janice Darden, Sheila Peel, Diane Epperson, Kelly McKee, Jeffrey R Currier, Jason Okulicz, Dominic Paquin-Proulx, Jessica Cowden, Kristina Peachman
BACKGROUND: COVID-19 vaccines have been critical for protection against severe disease following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but gaps remain in our understanding of the immune responses that contribute to controlling subclinical and mild infections. METHODS: Vaccinated, active-duty US military service members were enrolled in a non-interventional, minimal-risk, observational study starting in May, 2021. Clinical data, serum, and saliva samples were collected from study participants and were used to characterise the humoral immune responses to vaccination and to assess its impact on clinical and subclinical infections, as well as virologic outcomes of breakthrough infections (BTI) including viral load and infection duration...
July 4, 2023: EBioMedicine