keyword
https://read.qxmd.com/read/37468018/bronchoscopy-for-refractory-unexplained-cough-with-mucus
#21
JOURNAL ARTICLE
James Wingfield Digby, Jenny King, Bashar Al-Sheklly, Paul Marsden, Steve Fowler, Jaclyn Smith
INTRODUCTION: Refractory/unexplained cough (RUCC) is typically associated with throat symptoms and a dry cough. Some patients attending specialist cough clinics however, report sputum production (>1 tablespoon daily) and atypical sensations (urge-to-cough in chest). Bronchoscopy findings in this specific cohort have rarely been described. AIMS: We aimed to evaluate bronchoscopy, bronchoalveolar lavage (BAL) cell differential and microbiology findings in RUCC with mucus production...
July 17, 2023: Respiratory Medicine
https://read.qxmd.com/read/37413891/humoral-immune-responses-associated-with-control-of-sars-cov-2-breakthrough-infections-in-a-vaccinated-us-military-population
#22
JOURNAL ARTICLE
Gregory D Gromowski, Camila Macedo Cincotta, Sandra Mayer, Jocelyn King, Isabella Swafford, Michael K McCracken, Dante Coleman, Jennifer Enoch, Casey Storme, Janice Darden, Sheila Peel, Diane Epperson, Kelly McKee, Jeffrey R Currier, Jason Okulicz, Dominic Paquin-Proulx, Jessica Cowden, Kristina Peachman
BACKGROUND: COVID-19 vaccines have been critical for protection against severe disease following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but gaps remain in our understanding of the immune responses that contribute to controlling subclinical and mild infections. METHODS: Vaccinated, active-duty US military service members were enrolled in a non-interventional, minimal-risk, observational study starting in May, 2021. Clinical data, serum, and saliva samples were collected from study participants and were used to characterise the humoral immune responses to vaccination and to assess its impact on clinical and subclinical infections, as well as virologic outcomes of breakthrough infections (BTI) including viral load and infection duration...
July 4, 2023: EBioMedicine
https://read.qxmd.com/read/37404021/impact-of-sars-cov-2-infective-exacerbation-of-chronic-obstructive-pulmonary-disease-on-clinical-outcomes-in-a-prospective-cohort-study-of-hospitalised-adults
#23
JOURNAL ARTICLE
Catherine Hyams, George Qian, George Nava, Robert Challen, Elizabeth Begier, Jo Southern, Maria Lahuerta, Jennifer L Nguyen, Jade King, Anna Morley, Madeleine Clout, Nick Maskell, Luis Jodar, Jennifer Oliver, Gillian Ellsbury, John M McLaughlin, Bradford D Gessner, Adam Finn, Leon Danon, James W Dodd
OBJECTIVES: To determine whether acute exacerbations of chronic obstructive pulmonary disease (AECOPD) triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have worse outcomes than AECOPD caused by other infectious agents or non-infective AECOPD (NI-COPD). DESIGN: A two-hospital prospective cohort study of adults hospitalised with acute respiratory disease. We compared outcomes with AECOPD and a positive test for SARS-CoV-2 (n = 816), AECOPD triggered by other infections (n = 3038) and NI-COPD (n = 994)...
July 5, 2023: Journal of the Royal Society of Medicine
https://read.qxmd.com/read/37280747/sleep-disordered-breathing-in-children-with-craniofacial-anomalies
#24
JOURNAL ARTICLE
Juthamas Pongchangyoo, Sumalee Hantragool, Nond Rojvachiranonda, Watit Niyomkarn
Sleep-disordered breathing (SDB) is a common disorder in children, characterized by snoring and/or increased breathing force due to narrowing and increased upper airway collapse while sleeping. Over the last decade, it has been recognized that SDB occurs more frequently in children with craniofacial anomalies, but data in Thailand is quite limited. This study retrospective descriptive study aims to find the prevalence of SDB among children with craniofacial anomalies in Thailand and associated risk factors by collecting data among Thai children with congenital craniofacial anomalies younger than 15 years old who visited the Princess Sirindhorn Craniofacial Center at King Chulalongkorn Memorial Hospital between 2016 and 2021...
June 7, 2023: Journal of Craniofacial Surgery
https://read.qxmd.com/read/37260648/formulating-interprofessional-anesthesiology-and-operating-room-clinical-management-pathway-during-covid-19-pandemic-using-experiential-learning-theory-in-a-university-hospital-in-saudi-arabia
#25
JOURNAL ARTICLE
Wadeeah Bahaziq, Nada Noaman, Abeer AlHazmi, Baraa Tayeb, Abdulaziz M A Boker
As the number of COVID-19 cases is rapidly increasing internationally, management, recommendations and guidelines of COVID-19 are rapidly evolving and changing. Formulating local clinical management policies among institutions adopting these recommendations is vital to staff as well as the patients' safety. Also, training multidisciplinary teams on these policies is an important, yet challenging, part of the process. The purpose of this paper is to present the process that has been followed to formulate COVID-19-specific response anesthesiology and operating room (OR) policies at King Abdulaziz University Hospital, by applying David A...
2023: Saudi Journal of Anaesthesia
https://read.qxmd.com/read/37245337/targeting-calcium-signaling-by-inositol-trisphosphate-receptors-a-novel-mechanism-for-the-anti-asthmatic-effects-of-houttuynia-cordata
#26
JOURNAL ARTICLE
Alexis Shiying Huang, Benjamin Chun-Kit Tong, Harry Chun-Hin Hung, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Maggie Ming-Ki Leung, Jingxuan Bai, Xiuqiong Fu, Zhiling Yu, Min Li, Ting Fan Leung, Judith Choi-Wo Mak, George Pak-Heng Leung, King-Ho Cheung
Asthma is a chronic inflammatory disease characterized by airway hypersensitivity and remodeling. The current treatments provide only short-term benefits and may have undesirable side effects; thus, alternative or supplementary therapy is needed. Because intracellular calcium (Ca2+ ) signaling plays an essential role in regulating the contractility and remodeling of airway smooth muscle cells, the targeting of Ca2+ signaling is a potential therapeutic strategy for asthma. Houttuynia cordata is a traditional Chinese herb that is used to treat asthma due to its anti-allergic and anti-inflammatory properties...
May 26, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37197125/factors-associated-with-emergency-department-visits-or-readmission-of-late-preterm-infants-at-the-neonatal-intensive-care-department-national-guard-health-affairs-riyadh
#27
JOURNAL ARTICLE
Abdurhman S Alsaif, Khalid A Almutairi, Nawaf D Aljehani, Eid D Alanazi, Abdullah Alqahtani, Aly F Mahmoud
Background Infants who are born between 34 0/7 and 36 6/7 weeks of pregnancy as a result of maternal or fetal factors are defined as "late preterm infants". Compared to term infants, late preterm infants are more predisposed to pregnancy complications because they are less mature physiologically and metabolically. In addition, health practitioners still face difficulties in differentiating between term and late preterm infants due to similar general appearance. The aim of this study is to explore the epidemiology of readmission among late preterm infants at the National Guard Health Affairs...
April 2023: Curēus
https://read.qxmd.com/read/37182925/common-clinical-pattern-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-an-experience-from-a-multicenter-study-in-saudi-arabia
#28
MULTICENTER STUDY
Jumanah J Alfuwayris, Amal M Almulhim, Mohammed A Almansour, Marzouq A Albadi, Ibrahim A Alhomood, Faisal Alblewi, Abdullah U Althemery
OBJECTIVES: To understand the most common type and clinical manifestations of associated vasculitis (AAV) in the Saudi Arabia. METHODS: This retrospective study was conducted at King Fahad Medical City and the Security Forces Hospital Program, Riyadh, Saudi Arabia, between January 2014 and May 2022. Patients aged ≥18 years were included in the study and diagnosed based on clinical manifestations, serology, or histopathology according to the EMA algorithm...
May 2023: Saudi Medical Journal
https://read.qxmd.com/read/37120129/a-retrospective-comparison-of-the-king-laryngeal-tube-and-igel-supraglottic-airway-devices-a-study-for-the-cares-surveillance-group
#29
JOURNAL ARTICLE
Tanner Smida, James Menegazzi, James Scheidler, P S Martin, David Salcido, James Bardes
OBJECTIVE: Supraglottic airway devices are increasingly used during the resuscitation of out-of-hospital cardiac arrest (OHCA) patients in the United States and worldwide. In this study, we aimed to compare the neurologic outcomes of OHCA patients managed with the King Laryngeal Tube (King LT) to the neurologic outcomes of patients managed with the iGel. METHODS: We used the Cardiac Arrest Registry to Enhance Survival (CARES) public use research dataset for our analysis...
July 2023: Resuscitation
https://read.qxmd.com/read/37083896/military-standard-testing-of-commercially-available-supraglottic-airway-devices-for-use-in-a-military-combat-setting
#30
JOURNAL ARTICLE
Carlos Bedolla, Danielius Zilevicius, Grant Copeland, Marisa Guerra, Sophia Salazar, Michael D April, Brit Long, Jason F Naylor, Robert A De Lorenzo, Steven G Schauer, R Lyle Hood
INTRODUCTION: Airway obstruction is the second leading cause of death on the battlefield. The harsh conditions of the military combat setting require that devices be able to withstand extreme circumstances. Military standards (MIL-STD) testing is necessary before devices are fielded. We sought to determine the ability of supraglottic airway (SGA) devices to withstand MIL-STD testing. METHODS: We tested 10 SGA models according to nine MIL-STD-810H test methods. We selected these tests by polling five military and civilian emergency-medicine subject matter experts (SMEs), who weighed the relevance of each test...
April 21, 2023: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://read.qxmd.com/read/37060246/growth-and-microanatomy-of-the-paranasal-sinuses-in-two-species-of-new-world-monkeys
#31
JOURNAL ARTICLE
Timothy D Smith, S James Zinreich, Samuel Márquez, Scot E E King, Sian Evans, Valerie B DeLeon
Paranasal sinuses of living apes and humans grow with positive allometry, suggesting a novel mechanism for bone enlargement. Here, we examine the paranasal sinuses of the owl monkey (Aotus spp.) and a tamarin (Saguinus midas) across postnatal development. The prediction that paranasal sinuses grow disproportionately faster than the main nasal chamber is tested. We used diffusible iodine-based contrast-enhanced computed tomography and histology to study sinuses in eight Aotus and three tamarins ranging from newborn to adult ages...
April 15, 2023: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://read.qxmd.com/read/37016111/the-evolution-of-equipment-and-technology-for-visualising-the-larynx-and-airway
#32
JOURNAL ARTICLE
Duncan King, Alison Blair
Laryngoscopy and endotracheal intubation are the core skills of an anaesthetist. The tools and equipment used today are unrecognisable from the methods used in the first recorded attempts at laryngoscopy over 200 years ago. The evolution of the modern-day laryngoscopes has mirrored advancements in technology within general society, and particularly with regard to computer and fibreoptic technology over the last 30 years. The development of these modern visualisation devices would not have been possible without those that went before it, as each new device has been influenced by the previous...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/36946142/endobronchial-intubation-with-the-king-vision-%C3%A2-and-mcgrath-%C3%A2-laryngoscopes-in-simulated-easy-and-difficult-airways-by-novices-ekingmath
#33
JOURNAL ARTICLE
Alaa M Khidr, Jumana Masoudi, Sarah AlAboud, Mashael Alshahrani, Aziza Bokhari, Massimiliano Sorbello, Ivana Zdravkovic, Mohamed A Khalil, Saeed Al Shadowy, Talal Al Ghamdi, Abdulmohsen Al'ghamdi, Summayah Fallatah, Mohamed R El Tahan
Objective . The competency of using video laryngoscopes (VL) for double-lumen tube (DLT) endobronchial intubations can be improved with constant training as assessed by measuring the learning curves. We hypothesized that the time to DLT intubation would be reduced over the intubation attempts. Design . A crossover manikin study. Settings . University-affiliated hospital. Participants . Forty-two novice medical students unfamiliar with DLT intubation. Interventions. Participants were randomly allocated to two sequences, including DLT intubation, using King Vision and McGrath VLs...
March 22, 2023: Seminars in Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/36937129/reassessment-of-the-need-for-asthmatic-patients-for-biologic-treatment-in-a-tertiary-care-hospital
#34
JOURNAL ARTICLE
Sami M Alyami, Mosaad I Alshahwan, Hamad S Alshammari, Faisal M Abugamza, Sultan N Alotaibi, Omar A Abuoliat
BACKGROUND:  Asthma is a common chronic inflammatory airway condition. In difficult-to-treat asthma, poor control can be linked to multiple factors like the presence of uncontrolled comorbidities (e.g. gastroesophageal reflux and allergic rhinitis), as well as to poor inhaler use techniques and adherence. In this study we wanted to evaluate our severe asthma patients already on a biologic treatment with regard to presence of any of these factors.  Method: A questionnaire-based study, filled by investigators through direct interview with patients...
March 2023: Curēus
https://read.qxmd.com/read/36865505/endotracheal-intubation-with-king-vision-video-laryngoscope-vs-macintosh-direct-laryngoscope-in-icu-a-comparative-evaluation-of-performance-and-outcomes
#35
JOURNAL ARTICLE
Moturu Dharanindra, Prashant Pandurang Jedge, Vishwanath Chandrashekhar Patil, Sampada Sameer Kulkarni, Jignesh Shah, Shivakumar Iyer, Krishna Shriram Dhanasekaran
BACKGROUND: Endotracheal intubation to protect airway patency in critically ill patients with the use of videolaryngoscopes has been emerging and their expertise to handle is crucial. Our study focuses on the performance and outcomes of King Vision video laryngoscope (KVVL) in intensive care unit (ICU) compared to Macintosh direct laryngoscope (DL). MATERIALS AND METHODS: This comparative study was conducted by randomizing 143 critically ill patients in ICU into two groups: KVVL and Macintosh DL ( n = 73; n = 70)...
February 2023: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/36863703/thoracic-society-of-australia-and-new-zealand-tsanz-position-statement-on-chronic-suppurative-lung-disease-and-bronchiectasis-in-children-adolescents-and-adults-in-australia-and-new-zealand
#36
JOURNAL ARTICLE
Anne B Chang, Scott C Bell, Catherine A Byrnes, Paul Dawkins, Anne E Holland, Emma Kennedy, Paul T King, Pamela Laird, Sarah Mooney, Lucy Morgan, Marianne Parsons, Betty Poot, Maree Toombs, Paul J Torzillo, Keith Grimwood
This position statement, updated from the 2015 guidelines for managing Australian and New Zealand children/adolescents and adults with chronic suppurative lung disease (CSLD) and bronchiectasis, resulted from systematic literature searches by a multi-disciplinary team that included consumers. The main statements are: Diagnose CSLD and bronchiectasis early; this requires awareness of bronchiectasis symptoms and its co-existence with other respiratory diseases (e.g., asthma, chronic obstructive pulmonary disease)...
April 2023: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/36852927/single-cell-rna-sequencing-reveals-unique-monocyte-derived-interstitial-macrophage-subsets-during-lipopolysaccharide-induced-acute-lung-inflammation
#37
JOURNAL ARTICLE
Peter K Moore, Kelsey C Anderson, Shannon A McManus, Ting-Hui Tu, Emily M King, Kara J Mould, Elizabeth F Redente, Peter M Henson, William J Janssen, Alexandra L McCubbrey
Interstitial macrophages (IMs) reside in the lung tissue surrounding key structures including airways, vessels, and alveoli. Recent work has described IM heterogeneity during homeostasis, however, there are limited data on IMs during inflammation. We sought to characterize IM origin, subsets, and transcriptomic profiles during homeostasis and lipopolysaccharide (LPS) induced acute lung inflammation. During homeostasis, we used three complementary methods, spectral flow cytometry, single-cell RNA-sequencing, and gene regulatory network enrichment, to demonstrate that IMs can be divided into two core subsets distinguished by surface and transcriptional expression of folate receptor β ( Folr2 /FRβ)...
April 1, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/36846324/editorial-physiological-phenotyping-in-respiratory-diseases-new-approaches
#38
EDITORIAL
G G King, F Formenti, N Petousi
No abstract text is available yet for this article.
2023: Frontiers in Physiology
https://read.qxmd.com/read/36652451/a-retrospective-nationwide-comparison-of-the-igel-and-king-laryngeal-tube-supraglottic-airways-for-out-of-hospital-cardiac-arrest-resuscitation
#39
JOURNAL ARTICLE
Tanner Smida, James Menegazzi, Remle Crowe, James Scheidler, David Salcido, James Bardes
INTRODUCTION: While various supraglottic airway devices are available for use during out-of-hospital cardiac arrest (OHCA) resuscitation, comparisons of patient outcomes by device are limited. In this study, we aimed to compare outcomes of OHCA patients who had airway management by emergency medical services (EMS) with the iGel or King-LT. METHODS: We used the 2018-2021 ESO Data Collaborative public use research datasets for this retrospective study. All patients with non-traumatic OHCA who had iGels or King-LTs inserted by EMS were included...
February 13, 2023: Prehospital Emergency Care
https://read.qxmd.com/read/36601212/the-impact-of-bilevel-positive-airway-pressure-bipap-application-timing-on-emergency-room-length-of-stay-in-patients-with-pulmonary-edema-a-single-center-retrospective-cohort-study
#40
JOURNAL ARTICLE
Sumaya Khayat, Majid Ali, Lama Almasoudi, Alaa Fatani, Walaa Albarnawi, Moayad Bsooki, Mohammad Ismail
BACKGROUND:  Bilevel positive airway pressure (BiPAP) is a form of non-invasive ventilation (NIV) that is used to help and facilitate breathing. Our objective is to evaluate the impact of BiPAP application time on the length of emergency room (ER) stay in pulmonary edema patients. METHOD: This is a retrospective cohort study that included patients who presented to the ER at King Abdullah Medical City (KAMC) from June 2019 to June 2021...
December 2022: Curēus
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